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Ted M. Dawson - Publications

Affiliations: 
Johns Hopkins University School of Medicine, Baltimore, MD, United States 
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Year Citation  Score
2024 Ashraf D, Khan MR, Dawson TM, Dawson VL. Protein Translation in the Pathogenesis of Parkinson's Disease. International Journal of Molecular Sciences. 25. PMID 38397070 DOI: 10.3390/ijms25042393  0.529
2024 Patel J, Dawson VL, Dawson TM. Blocking the Self-Destruct Program of Dopamine Neurons through Macrophage Migration Inhibitory Factor Nuclease Inhibition. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 38396375 DOI: 10.1002/mds.29748  0.555
2024 Chen C, Kumbhar R, Wang H, Yang X, Gadhave K, Rastegar C, Kimura Y, Behensky A, Kotha S, Kuo G, Katakam S, Jeong D, Wang L, Wang A, Chen R, ... ... Dawson TM, et al. Lymphocyte-Activation Gene 3 Facilitates Pathological Tau Neuron-to-Neuron Transmission. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2303775. PMID 38327094 DOI: 10.1002/advs.202303775  0.502
2023 Geibl FF, Henrich MT, Xie Z, Zampese E, Tkatch T, Wokosin DL, Nasiri E, Grotmann CA, Dawson VL, Dawson TM, Chandel NS, Oertel WH, Surmeier DJ. α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson's disease. Biorxiv : the Preprint Server For Biology. PMID 38168401 DOI: 10.1101/2023.12.11.571045  0.569
2023 Wang H, Yin X, Xu J, Chen L, Karuppagounder SS, Xu E, Mao X, Dawson VL, Dawson TM. Interspecies chimerism with human embryonic stem cells generates functional human dopamine neurons at low efficiency. Stem Cell Reports. PMID 38134925 DOI: 10.1016/j.stemcr.2023.11.009  0.719
2023 Krug S, Gupta M, Kumar P, Feller L, Ihms EA, Kang BG, Srikrishna G, Dawson TM, Dawson VL, Bishai WR. Inhibition of host PARP1 contributes to the anti-inflammatory and antitubercular activity of pyrazinamide. Nature Communications. 14: 8161. PMID 38071218 DOI: 10.1038/s41467-023-43937-1  0.419
2023 Khan MR, Yin X, Kang SU, Mitra J, Wang H, Ryu T, Brahmachari S, Karuppagounder SS, Kimura Y, Jhaldiyal A, Kim HH, Gu H, Chen R, Redding-Ochoa J, Troncoso J, ... ... Dawson TM, et al. Enhanced mTORC1 signaling and protein synthesis in pathologic α-synuclein cellular and animal models of Parkinson's disease. Science Translational Medicine. 15: eadd0499. PMID 38019930 DOI: 10.1126/scitranslmed.add0499  0.823
2023 Kang H, Park S, Jo A, Mao X, Kumar M, Park CH, Ahn JY, Lee Y, Choi JY, Lee YS, Dawson VL, Dawson TM, Kam TI, Shin JH. PARIS undergoes liquid-liquid phase separation and poly(ADP-ribose)-mediated solidification. Embo Reports. e56166. PMID 37870275 DOI: 10.15252/embr.202256166  0.657
2023 Bae JH, Jo A, Cho SC, Lee YI, Kam TI, You CL, Jeong HJ, Kim H, Jeong MH, Jeong Y, Ha YW, Kim YS, Kim J, Woo SH, Kim MS, ... ... Dawson TM, et al. Farnesol prevents aging-related muscle weakness in mice through enhanced farnesylation of Parkin-interacting substrate. Science Translational Medicine. 15: eabh3489. PMID 37647389 DOI: 10.1126/scitranslmed.abh3489  0.406
2023 Wang H, Chen R, Xiao L, Kumar M, Acevedo-Cintrón J, Siuda J, Koziorowski D, Wszolek ZK, Dawson VL, Dawson TM. Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PINK1-deficient Human Dopamine Neurons. Biorxiv : the Preprint Server For Biology. PMID 37425943 DOI: 10.1101/2023.06.23.546087  0.508
2023 Gharagozloo M, Galleguillos D, Jank L, Sotirchos ES, Smith MD, Garton T, Kumar S, Hussein O, Potluri S, Taylor M, Siu C, Mace JW, Dawson T, Dawson VL, Lee S, et al. The Effects of NLY01, a Novel Glucagon-Like Peptide-1 Receptor Agonist, on Cuprizone-Induced Demyelination and Remyelination: Challenges and Future Perspectives. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 37296356 DOI: 10.1007/s13311-023-01390-4  0.414
2023 Chen C, Kumbhar R, Wang H, Yang X, Gadhave K, Rastegar C, Kimura Y, Behensky A, Katakam S, Jeong D, Wang L, Wang A, Chen R, Zhang S, Jin L, ... ... Dawson TM, et al. Pathological Tau transmission initiated by binding lymphocyte-activation gene 3. Biorxiv : the Preprint Server For Biology. PMID 37293032 DOI: 10.1101/2023.05.16.541015  0.678
2023 Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, ... ... Dawson TM, et al. Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death and Differentiation. PMID 37100955 DOI: 10.1038/s41418-023-01153-w  0.567
2023 Serey-Gaut M, Cortes M, Makrythanasis P, Suri M, Taylor AMR, Sullivan JA, Asleh AN, Mitra J, Dar MA, McNamara A, Shashi V, Dugan S, Song X, Rosenfeld JA, Cabrol C, ... ... Dawson TM, et al. Bi-allelic TTI1 variants cause an autosomal-recessive neurodevelopmental disorder with microcephaly. American Journal of Human Genetics. PMID 36724785 DOI: 10.1016/j.ajhg.2023.01.006  0.417
2023 Yazar V, Dawson VL, Dawson TM, Kang SU. DNA Methylation Signature of Aging: Potential Impact on the Pathogenesis of Parkinson's Disease. Journal of Parkinson's Disease. PMID 36710687 DOI: 10.3233/JPD-223517  0.463
2023 Karuppagounder SS, Wang H, Kelly T, Rush R, Nguyen R, Bisen S, Yamashita Y, Sloan N, Dang B, Sigmon A, Lee HW, Marino Lee S, Watkins L, Kim E, Brahmachari S, ... ... Dawson TM, et al. The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson's disease. Science Translational Medicine. 15: eabp9352. PMID 36652533 DOI: 10.1126/scitranslmed.abp9352  0.549
2022 Jang Y, Pletnikova O, Troncoso JC, Pantelyat AY, Dawson TM, Rosenthal LS, Na CH. Mass spectrometry-based proteomics analysis of human substantia nigra from Parkinson's disease patients identifies multiple pathways potentially involved in the disease. Molecular & Cellular Proteomics : McP. 100452. PMID 36423813 DOI: 10.1016/j.mcpro.2022.100452  0.32
2022 Patel J, Panicker N, Dawson VL, Dawson TM. Cell Biology of Parkin: Clues to the Development of New Therapeutics for Parkinson's Disease. Cns Drugs. 36: 1249-1267. PMID 36378485 DOI: 10.1007/s40263-022-00973-7  0.749
2022 Scott L, Karuppagounder SS, Neifert S, Kang BG, Wang H, Dawson VL, Dawson TM. The absence of Parkin does not promote dopamine or mitochondrial dysfunction in PolgA mitochondrial mutator mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 36280265 DOI: 10.1523/JNEUROSCI.0545-22.2022  0.506
2022 Biswas D, Dawson VL, Dawson TM. Pharmacologic inhibition of MIF nuclease: A new treatment paradigm to treat cell death. Clinical and Translational Medicine. 12: e1044. PMID 36125899 DOI: 10.1002/ctm2.1044  0.771
2022 Gao J, Mewborne QT, Girdhar A, Sheth U, Coyne AN, Punathil R, Kang BG, Dasovich M, Veire A, DeJesus Hernandez M, Liu S, Shi Z, Dafinca R, Fouquerel E, Talbot K, ... ... Dawson TM, et al. Poly(ADP-ribose) promotes toxicity of arginine-rich dipeptide repeat proteins. Science Translational Medicine. 14: eabq3215. PMID 36103513 DOI: 10.1126/scitranslmed.abq3215  0.435
2022 Kam TI, Park H, Chou SC, Van Vranken JG, Mittenbühler MJ, Kim H, A M, Choi YR, Biswas D, Wang J, Shin Y, Loder A, Karuppagounder SS, Wrann CD, Dawson VL, ... ... Dawson TM, et al. Amelioration of pathologic α-synuclein-induced Parkinson's disease by irisin. Proceedings of the National Academy of Sciences of the United States of America. 119: e2204835119. PMID 36044549 DOI: 10.1073/pnas.2204835119  0.818
2022 Umanah GKE, Abalde-Atristain L, Khan MR, Mitra J, Dar MA, Chang M, Tangella K, McNamara A, Bennett S, Chen R, Aggarwal V, Cortes M, Worley PF, Ha T, Dawson TM, et al. AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1. Nature Communications. 13: 4836. PMID 35977929 DOI: 10.1038/s41467-022-32365-2  0.78
2022 Panicker N, Kam TI, Wang H, Neifert S, Chou SC, Kumar M, Brahmachari S, Jhaldiyal A, Hinkle JT, Akkentli F, Mao X, Xu E, Karuppagounder SS, Hsu ET, Kang SU, ... ... Dawson TM, et al. Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease. Neuron. PMID 35654037 DOI: 10.1016/j.neuron.2022.05.009  0.836
2022 Park H, Kam TI, Peng H, Chou SC, Mehrabani-Tabari AA, Song JJ, Yin X, Karuppagounder SS, Umanah GK, Rao AVS, Choi Y, Aggarwal A, Chang S, Kim H, Byun J, ... ... Dawson TM, et al. PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson's disease. Cell. PMID 35545089 DOI: 10.1016/j.cell.2022.04.020  0.56
2022 Harraz MM, Malla AP, Semenza ER, Shishikura M, Singh M, Hwang Y, Kang IG, Song YJ, Snowman AM, Cortés P, Karuppagounder SS, Dawson TM, Dawson VL, Snyder SH. A high-affinity cocaine binding site associated with the brain acid soluble protein 1. Proceedings of the National Academy of Sciences of the United States of America. 119: e2200545119. PMID 35412917 DOI: 10.1073/pnas.2200545119  0.743
2022 Hinkle JT, Patel J, Panicker N, Karuppagounder SS, Biswas D, Belingon B, Chen R, Brahmachari S, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM. STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy. Proceedings of the National Academy of Sciences of the United States of America. 119: e2118819119. PMID 35394877 DOI: 10.1073/pnas.2118819119  0.828
2022 Pirooznia SK, Wang H, Panicker N, Kumar M, Neifert S, Dar MA, Lau E, Kang BG, Redding-Ochoa J, Troncoso JC, Dawson VL, Dawson TM. Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson's disease. Science Advances. 8: eabh1824. PMID 35363524 DOI: 10.1126/sciadv.abh1824  0.778
2022 Sterling JK, Kam TI, Guttha S, Park H, Baumann B, Mehrabani-Tabari AA, Schultz H, Anderson B, Alnemri A, Chou SC, Troncoso JC, Dawson VL, Dawson TM, Dunaief JL. Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein. Cell Reports. 38: 110358. PMID 35172141 DOI: 10.1016/j.celrep.2022.110358  0.479
2021 Chou SC, Aggarwal A, Dawson VL, Dawson TM, Kam TI. Recent advances in preventing neurodegenerative diseases. Faculty Reviews. 10: 81. PMID 35028646 DOI: 10.12703/r/10-81  0.49
2021 Kim JW, Yin X, Martin I, Xiong Y, Eacker SM, Ingolia NT, Dawson TM, Dawson VL. Dysregulated mRNA Translation in the G2019S LRRK2 and LRRK2 Knock-Out Mouse Brains. Eneuro. PMID 34759048 DOI: 10.1523/ENEURO.0310-21.2021  0.809
2021 Wyse RK, Stott SRW, Mursaleen L, Matthews H, Dawson VL, Dawson TM. Waiting for PARIS-A Biological Target in Search of a Drug. Journal of Parkinson's Disease. PMID 34744054 DOI: 10.3233/jpd-212945  0.473
2021 Yazar V, Kang SU, Ha S, Dawson VL, Dawson TM. Integrative genome-wide analysis of dopaminergic neuron-specific PARIS expression in Drosophila dissects recognition of multiple PPAR-γ associated gene regulation. Scientific Reports. 11: 21500. PMID 34728675 DOI: 10.1038/s41598-021-00858-7  0.56
2021 Pirooznia SK, Rosenthal LS, Dawson VL, Dawson TM. Parkinson Disease: Translating Insights from Molecular Mechanisms to Neuroprotection. Pharmacological Reviews. 73: 33-97. PMID 34663684 DOI: 10.1124/pharmrev.120.000189  0.508
2021 Seo BA, Kim D, Hwang H, Kim MS, Ma SX, Kwon SH, Kweon SH, Wang H, Yoo JM, Choi S, Kwon SH, Kang SU, Kam TI, Kim K, Karuppagounder SS, ... ... Dawson TM, et al. TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease. Neuron. PMID 34644545 DOI: 10.1016/j.neuron.2021.09.031  0.713
2021 Kim JJ, Lee SY, Hwang Y, Kim S, Chung JM, Park S, Yoon J, Yun H, Ji JH, Chae S, Cho H, Kim CG, Dawson TM, Kim H, Dawson VL, et al. USP39 promotes non-homologous end-joining repair by poly(ADP-ribose)-induced liquid demixing. Nucleic Acids Research. PMID 34614178 DOI: 10.1093/nar/gkab892  0.399
2021 Kim H, Shin JY, Jo A, Kim JH, Park S, Choi JY, Kang HC, Dawson VL, Dawson TM, Shin JH, Lee Y. Parkin interacting substrate phosphorylation by c-Abl drives dopaminergic neurodegeneration. Brain : a Journal of Neurology. PMID 34581802 DOI: 10.1093/brain/awab356  0.503
2021 Lüscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, Cohen M, Corda D, Dantzer F, Daugherty MD, Dawson TM, Dawson VL, Deindl S, Fehr AR, Feijs KLH, et al. ADP-ribosyltransferases, an update on function and nomenclature. The Febs Journal. PMID 34323016 DOI: 10.1111/febs.16142  0.45
2021 Jo A, Lee Y, Kam TI, Kang SU, Neifert S, Karuppagounder SS, Khang R, Kang H, Park H, Chou SC, Oh S, Jiang H, Swing DA, Ham S, Pirooznia S, ... ... Dawson TM, et al. PARIS farnesylation prevents neurodegeneration in models of Parkinson's disease. Science Translational Medicine. 13. PMID 34321320 DOI: 10.1126/scitranslmed.aax8891  0.711
2021 Gharagozloo M, Smith MD, Sotirchos ES, Jin J, Meyers K, Taylor M, Garton T, Bannon R, Lord HN, Dawson TM, Dawson VL, Lee S, Calabresi PA. Therapeutic Potential of a Novel Glucagon-like Peptide-1 Receptor Agonist, NLY01, in Experimental Autoimmune Encephalomyelitis. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 34260042 DOI: 10.1007/s13311-021-01088-5  0.448
2021 Kim NS, Ringeling FR, Zhou Y, Nguyen HN, Temme SJ, Lin YT, Eacker S, Dawson VL, Dawson TM, Xiao B, Hsu KS, Canzar S, Li W, Worley P, Christian KM, et al. CYFIP1 Dosages Exhibit Divergent Behavioral Impact via Diametric Regulation of NMDA Receptor Complex Translation in Mouse Models of Psychiatric Disorders. Biological Psychiatry. PMID 34247782 DOI: 10.1016/j.biopsych.2021.04.023  0.772
2021 Zhang L, Chen C, Fu J, Lilley B, Berlinicke C, Hansen B, Ding D, Wang G, Wang T, Shou D, Ye Y, Mulligan T, Emmerich K, Saxena MT, Hall KR, ... ... Dawson TM, et al. Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa. Elife. 10. PMID 34184634 DOI: 10.7554/eLife.57245  0.414
2021 Zhang S, Liu YQ, Jia C, Lim YJ, Feng G, Xu E, Long H, Kimura Y, Tao Y, Zhao C, Wang C, Liu Z, Hu JJ, Ma MR, Liu Z, ... ... Dawson TM, et al. Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34172566 DOI: 10.1073/pnas.2011196118  0.678
2021 Ma SX, Seo BA, Kim D, Xiong Y, Kwon SH, Brahmachari S, Kim S, Kam TI, Nirujogi RS, Kwon SH, Dawson VL, Dawson TM, Pandey A, Na CH, Ko HS. Complement and Coagulation Cascades are Potentially Involved in Dopaminergic Neurodegeneration in α-Synuclein-Based Mouse Models of Parkinson's Disease. Journal of Proteome Research. PMID 34061533 DOI: 10.1021/acs.jproteome.0c01002  0.54
2021 Koehler RC, Dawson VL, Dawson TM. Targeting Parthanatos in Ischemic Stroke. Frontiers in Neurology. 12: 662034. PMID 34025565 DOI: 10.3389/fneur.2021.662034  0.448
2021 Park JS, Kam TI, Lee S, Park H, Oh Y, Kwon SH, Song JJ, Kim D, Kim H, Jhaldiyal A, Na DH, Lee KC, Park EJ, Pomper MG, Pletnikova O, ... ... Dawson TM, et al. Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer's disease. Acta Neuropathologica Communications. 9: 78. PMID 33902708 DOI: 10.1186/s40478-021-01180-z  0.787
2021 Yin X, Kim JW, Liu S, Dawson TM, Dawson VL. Protocol for measurement of calcium dysregulation in human induced pluripotent stem cell-derived dopaminergic neurons. Star Protocols. 2: 100405. PMID 33855307 DOI: 10.1016/j.xpro.2021.100405  0.491
2021 Liu S, Zhou M, Ruan Z, Wang Y, Chang C, Sasaki M, Rajaram V, Lemoff A, Nambiar K, Wang JE, Hatanpaa KJ, Luo W, Dawson TM, Dawson VL, Wang Y. AIF3 splicing switch triggers neurodegeneration. Molecular Neurodegeneration. 16: 25. PMID 33853653 DOI: 10.1186/s13024-021-00442-7  0.459
2021 Gu H, Yang X, Mao X, Xu E, Qi C, Wang H, Brahmachari S, York B, Sriparna M, Li A, Chang M, Patel P, Dawson VL, Dawson TM. Lymphocyte Activation Gene 3 (Lag3) Contributes to α-Synucleinopathy in α-Synuclein Transgenic Mice. Frontiers in Cellular Neuroscience. 15: 656426. PMID 33776654 DOI: 10.3389/fncel.2021.656426  0.732
2021 Panicker N, Ge P, Dawson VL, Dawson TM. The cell biology of Parkinson's disease. The Journal of Cell Biology. 220. PMID 33749710 DOI: 10.1083/jcb.202012095  0.832
2021 Fais M, Sanna G, Galioto M, Nguyen TTD, Trần MUT, Sini P, Carta F, Turrini F, Xiong Y, Dawson TM, Dawson VL, Crosio C, Iaccarino C. LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8. Cells. 10. PMID 33498474 DOI: 10.3390/cells10020203  0.512
2021 Liu Y, Mao Y, Xu E, Jia H, Zhang S, Dawson VL, Dawson TM, Li Y, Zheng Z, He W, Mao X. Nanozyme scavenging ROS for prevention of pathologic α-synuclein transmission in Parkinson’s disease Nano Today. 36: 101027. DOI: 10.1016/j.nantod.2020.101027  0.456
2020 Jia L, Liu Y, Wang W, Wang Y, Liu H, Liu F, Chen R, Dawson VL, Dawson TM, Lu F, Liu L, Wang Y, Mao X. Molecular Mediation of Prion-like α-Synuclein Fibrillation from Toxic PFFs to Nontoxic Species. Acs Applied Bio Materials. 3: 6096-6102. PMID 35021742 DOI: 10.1021/acsabm.0c00684  0.699
2020 Yin X, Dawson TM, Dawson VL. Integration of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons into Rat Brain Circuits. Bio-Protocol. 10: e3746. PMID 33659406 DOI: 10.21769/BioProtoc.3746  0.469
2020 Henrich MT, Geibl FF, Lakshminarasimhan H, Stegmann A, Giasson BI, Mao X, Dawson VL, Dawson TM, Oertel WH, Surmeier DJ. Determinants of seeding and spreading of α-synuclein pathology in the brain. Science Advances. 6. PMID 33177086 DOI: 10.1126/sciadv.abc2487  0.704
2020 Umanah GKE, Ghasemi M, Yin X, Chang M, Kim JW, Zhang J, Ma E, Scarffe LA, Lee YI, Chen R, Tangella K, McNamara A, Abalde-Atristain L, Dar MA, Bennett S, ... ... Dawson TM, et al. AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF. Cell Reports. 33: 108329. PMID 33147468 DOI: 10.1016/j.celrep.2020.108329  0.787
2020 Kim JW, Yin X, Jhaldiyal A, Khan MR, Martin I, Xie Z, Perez-Rosello T, Kumar M, Abalde-Atristain L, Xu J, Chen L, Eacker SM, Surmeier DJ, Ingolia NT, Dawson TM, et al. Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis. Cell Stem Cell. PMID 32846140 DOI: 10.1016/J.Stem.2020.08.002  0.818
2020 Kumar M, Acevedo-Cintrón J, Jhaldiyal A, Wang H, Andrabi SA, Eacker S, Karuppagounder SS, Brahmachari S, Chen R, Kim H, Ko HS, Dawson VL, Dawson TM. Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons. Stem Cell Reports. PMID 32795422 DOI: 10.1016/J.Stemcr.2020.07.013  0.803
2020 Kam TI, Hinkle JT, Dawson TM, Dawson VL. Microglia and astrocyte dysfunction in parkinson's disease. Neurobiology of Disease. 105028. PMID 32736085 DOI: 10.1016/J.Nbd.2020.105028  0.591
2020 Wan YW, Al-Ouran R, Mangleburg CG, Perumal TM, Lee TV, Allison K, Swarup V, Funk CC, Gaiteri C, Allen M, Wang M, Neuner SM, Kaczorowski CC, Philip VM, Howell GR, ... ... Dawson TM, et al. Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models. Cell Reports. 32: 107908. PMID 32668255 DOI: 10.1016/J.Celrep.2020.107908  0.508
2020 Na CH, Sathe G, Rosenthal LS, Moghekar AR, Dawson VL, Dawson TM, Pandey A. Development of a novel method for the quantification of tyrosine 39 phosphorylated α- and β-synuclein in human cerebrospinal fluid. Clinical Proteomics. 17: 13. PMID 32390785 DOI: 10.1186/S12014-020-09277-8  0.574
2020 Park H, Kam TI, Dawson TM, Dawson VL. Poly (ADP-ribose) (PAR)-dependent cell death in neurodegenerative diseases. International Review of Cell and Molecular Biology. 353: 1-29. PMID 32381174 DOI: 10.1016/Bs.Ircmb.2019.12.009  0.589
2020 Agarwal A, Park S, Ha S, Kwon JS, Khan MR, Kang BG, Dawson TM, Dawson VL, Andrabi SA, Kang SU. Quantitative mass spectrometric analysis of the mouse cerebral cortex after ischemic stroke. Plos One. 15: e0231978. PMID 32315348 DOI: 10.1371/Journal.Pone.0231978  0.49
2020 Ge P, Dawson VL, Dawson TM. PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson's disease. Molecular Neurodegeneration. 15: 20. PMID 32169097 DOI: 10.1186/S13024-020-00367-7  0.736
2020 Pirooznia SK, Yuan C, Khan MR, Karuppagounder SS, Wang L, Xiong Y, Kang SU, Lee Y, Dawson VL, Dawson TM. PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency. Molecular Neurodegeneration. 15: 17. PMID 32138754 DOI: 10.1186/S13024-020-00363-X  0.825
2020 Panicker N, Kam T, Neifert S, Hinkle J, Mao X, Karuppagounder S, Wang H, Kumar M, Pirooznia S, Pletnikova O, Troncoso J, Dawson VL, Dawson TM. NLRP3 inflammasome activation in dopamine neurons contributes to neurodegeneration in Parkinson’s Disease The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.01881  0.808
2020 Jia L, Liu Y, Wang W, Wang Y, Liu H, Liu F, Chen R, Dawson VL, Dawson TM, Lu F, Liu L, Wang Y, Mao X. Molecular Mediation of Prion-like α-Synuclein Fibrillation from Toxic PFFs to Nontoxic Species Acs Applied Bio Materials. 3: 6096-6102. DOI: 10.1021/acsabm.0c00684  0.411
2019 Dawson VL, Dawson TM. Promising disease-modifying therapies for Parkinson's disease. Science Translational Medicine. 11. PMID 31776289 DOI: 10.1126/Scitranslmed.Aba1659  0.507
2019 Blauwendraat C, Reed X, Krohn L, Heilbron K, Bandres-Ciga S, Tan M, Gibbs JR, Hernandez DG, Kumaran R, Langston R, Bonet-Ponce L, Alcalay RN, Hassin-Baer S, Greenbaum L, Iwaki H, ... ... Dawson TM, et al. Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia. Brain : a Journal of Neurology. PMID 31755958 DOI: 10.1093/Brain/Awz350  0.336
2019 Yin X, Xu JC, Cho GS, Kwon C, Dawson TM, Dawson VL. Neurons Derived from Human Induced Pluripotent Stem Cells Integrate into Rat Brain Circuits and Maintain both Excitatory and Inhibitory Synaptic Activities. Eneuro. PMID 31413152 DOI: 10.1523/ENEURO.0148-19.2019  0.588
2019 Jin J, Smith MD, Kersbergen CJ, Kam TI, Viswanathan M, Martin K, Dawson TM, Dawson VL, Zack DJ, Whartenby K, Calabresi PA. Glial pathology and retinal neurotoxicity in the anterior visual pathway in experimental autoimmune encephalomyelitis. Acta Neuropathologica Communications. 7: 125. PMID 31366377 DOI: 10.1186/S40478-019-0767-6  0.511
2019 Kim S, Kwon SH, Kam TI, Panicker N, Karuppagounder SS, Lee S, Lee JH, Kim WR, Kook M, Foss CA, Shen C, Lee H, Kulkarni S, Pasricha PJ, Lee G, ... ... Dawson TM, et al. Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease. Neuron. PMID 31255487 DOI: 10.1016/J.Neuron.2019.05.035  0.802
2019 Brahmachari S, Lee S, Kim S, Yuan C, Karuppagounder SS, Ge P, Shi R, Kim EJ, Liu A, Kim D, Quintin S, Jiang H, Kumar M, Yun SP, Kam TI, ... ... Dawson TM, et al. Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease. Brain : a Journal of Neurology. PMID 31237944 DOI: 10.1093/Brain/Awz172  0.816
2019 Hinkle JT, Dawson VL, Dawson TM. The A1 astrocyte paradigm: New avenues for pharmacological intervention in neurodegeneration. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31136698 DOI: 10.1002/Mds.27718  0.563
2019 Panicker N, Sarkar S, Harischandra DS, Neal M, Kam TI, Jin H, Saminathan H, Langley M, Charli A, Samidurai M, Rokad D, Ghaisas S, Pletnikova O, Dawson VL, Dawson TM, et al. Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia. The Journal of Experimental Medicine. PMID 31036561 DOI: 10.1084/Jem.20182191  0.816
2019 Sabir MS, Blauwendraat C, Ahmed S, Serrano GE, Beach TG, Perkins M, Rice AC, Masliah E, Morris CM, Pihlstrom L, Pantelyat A, Resnick SM, Cookson MR, Hernandez DG, Albert M, ... Dawson TM, et al. Assessment of APOE in atypical parkinsonism syndromes. Neurobiology of Disease. PMID 30798004 DOI: 10.1016/J.Nbd.2019.02.016  0.305
2018 Xue Y, Zhan X, Sun S, Karuppagounder SS, Xia S, Dawson VL, Dawson TM, Laterra J, Zhang J, Ying M. Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons. Stem Cells Translational Medicine. PMID 30387318 DOI: 10.1002/Sctm.18-0036  0.807
2018 Kam TI, Mao X, Park H, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmachari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, ... ... Dawson TM, et al. Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease. Science (New York, N.Y.). 362. PMID 30385548 DOI: 10.1126/Science.Aat8407  0.823
2018 Dawson TM, Golde TE, Lagier-Tourenne C. Animal models of neurodegenerative diseases. Nature Neuroscience. 21: 1370-1379. PMID 30250265 DOI: 10.1038/S41593-018-0236-8  0.325
2018 Hinkle JT, Perepezko K, Mills KA, Mari Z, Butala A, Dawson TM, Pantelyat A, Rosenthal LS, Pontone GM. Dopamine transporter availability reflects gastrointestinal dysautonomia in early Parkinson disease. Parkinsonism & Related Disorders. PMID 30146185 DOI: 10.1016/J.Parkreldis.2018.08.010  0.386
2018 Chen-Plotkin AS, Albin R, Alcalay R, Babcock D, Bajaj V, Bowman D, Buko A, Cedarbaum J, Chelsky D, Cookson MR, Dawson TM, Dewey R, Foroud T, Frasier M, German D, et al. Finding useful biomarkers for Parkinson's disease. Science Translational Medicine. 10. PMID 30111645 DOI: 10.1126/Scitranslmed.Aam6003  0.332
2018 Yun SP, Kam TI, Panicker N, Kim S, Oh Y, Park JS, Kwon SH, Park YJ, Karuppagounder SS, Park H, Kim S, Oh N, Kim NA, Lee S, Brahmachari S, ... ... Dawson TM, et al. Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease. Nature Medicine. PMID 29892066 DOI: 10.1038/S41591-018-0051-5  0.814
2018 Hinkle JT, Perepezko K, Bakker CC, Broen MPG, Chin K, Dawson TM, Johnson V, Mari Z, Marvel CL, Mills KA, Pantelyat A, Pletnikova O, Rosenthal LS, Shepard MD, Stevens DA, et al. Onset and Remission of Psychosis in Parkinson's Disease: Pharmacologic and Motoric Markers. Movement Disorders Clinical Practice. 5: 31-38. PMID 29756003 DOI: 10.1002/Mdc3.12550  0.386
2018 Piard J, Essien Umanah GK, Harms FL, Abalde-Atristain L, Amram D, Chang M, Chen R, Alawi M, Salpietro V, Rees MI, Chung SK, Houlden H, Verloes A, Dawson TM, Dawson VL, et al. Reply: ATAD1 encephalopathy and stiff baby syndrome: a recognizable clinical presentation. Brain : a Journal of Neurology. PMID 29659731 DOI: 10.1093/Brain/Awy100  0.75
2018 Zhang J, Yang J, Wang H, Sherbini O, Keuss MJ, Umanah GK, Pai EL, Chi Z, Paldanius KM, He W, Wang H, Andrabi SA, Dawson TM, Dawson VL. The AAA + ATPase Thorase is neuroprotective against ischemic injury. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X18769770. PMID 29658368 DOI: 10.1177/0271678X18769770  0.635
2018 Jouroukhin Y, Kageyama Y, Misheneva V, Shevelkin A, Andrabi S, Prandovszky E, Yolken RH, Dawson VL, Dawson TM, Aja S, Sesaki H, Pletnikov MV. DISC1 regulates lactate metabolism in astrocytes: implications for psychiatric disorders. Translational Psychiatry. 8: 76. PMID 29643356 DOI: 10.1038/S41398-018-0123-9  0.521
2018 Jeong GR, Jang EH, Bae JR, Jun S, Kang HC, Park CH, Shin JH, Yamamoto Y, Tanaka-Yamamoto K, Dawson VL, Dawson TM, Hur EM, Lee BD. Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration. Molecular Neurodegeneration. 13: 8. PMID 29439717 DOI: 10.1186/S13024-018-0240-1  0.562
2018 Dawson TM, Dawson VL. Nitric Oxide Signaling in Neurodegeneration and Cell Death. Advances in Pharmacology (San Diego, Calif.). 82: 57-83. PMID 29413528 DOI: 10.1016/Bs.Apha.2017.09.003  0.579
2018 Piard J, Umanah GKE, Harms FL, Abalde-Atristain L, Amram D, Chang M, Chen R, Alawi M, Salpietro V, Rees MI, Chung SK, Houlden H, Verloes A, Dawson TM, Dawson VL, et al. A homozygous ATAD1 mutation impairs postsynaptic AMPA receptor trafficking and causes a lethal encephalopathy. Brain : a Journal of Neurology. PMID 29390050 DOI: 10.1093/Brain/Awx377  0.799
2018 Xiong Y, Neifert S, Karuppagounder SS, Liu Q, Stankowski JN, Lee BD, Ko HS, Lee Y, Grima JC, Mao X, Jiang H, Kang SU, Swing DA, Iacovitti L, Tessarollo L, ... Dawson TM, et al. Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 29386392 DOI: 10.1073/Pnas.1712648115  0.822
2018 Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, ... ... Dawson TM, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation. PMID 29362479 DOI: 10.1038/S41418-017-0012-4  0.484
2018 Kim S, Yun SP, Lee S, Umanah GE, Bandaru VVR, Yin X, Rhee P, Karuppagounder SS, Kwon SH, Lee H, Mao X, Kim D, Pandey A, Lee G, Dawson VL, ... Dawson TM, et al. GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers. Proceedings of the National Academy of Sciences of the United States of America. PMID 29311330 DOI: 10.1073/Pnas.1700465115  0.813
2018 Yun SP, Kim D, Kim S, Kim S, Karuppagounder SS, Kwon SH, Lee S, Kam TI, Lee S, Ham S, Park JH, Dawson VL, Dawson TM, Lee Y, Ko HS. α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism. Molecular Neurodegeneration. 13: 1. PMID 29310663 DOI: 10.1186/S13024-017-0233-5  0.825
2018 ANDO M, FIESEL FC, HUDEC R, CAULFIELD TR, OGAKI K, GÓRKA-SKOCZYLAS P, KOZIOROWSKI D, FRIEDMAN A, CHEN L, DAWSON VL, DAWSON TM, BU G, ROSS OA, WSZOLEK ZK, SPRINGER W. The PINK1 p.I368N Mutation Affects Protein Stability and Kinase Activity with Its Structural Change Juntendo Medical Journal. 64: 17-30. DOI: 10.14789/Jmj.2018.64.Jmjjmj17-R10  0.472
2017 Martos SN, Li T, Ramos RB, Lou D, Dai H, Xu JC, Gao G, Gao Y, Wang Q, An C, Zhang X, Jia Y, Dawson VL, Dawson TM, Ji H, et al. Two approaches reveal a new paradigm of 'switchable or genetics-influenced allele-specific DNA methylation' with potential in human disease. Cell Discovery. 3: 17038. PMID 29387450 DOI: 10.1038/Celldisc.2017.38  0.575
2017 Kaji S, Maki T, Kinoshita H, Uemura N, Ayaki T, Kawamoto Y, Furuta T, Urushitani M, Hasegawa M, Kinoshita Y, Ono Y, Mao X, Quach TH, Iwai K, Dawson VL, ... Dawson TM, et al. Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy. Stem Cell Reports. PMID 29337114 DOI: 10.1016/J.Stemcr.2017.12.001  0.68
2017 Umanah GKE, Pignatelli M, Yin X, Chen R, Crawford J, Neifert S, Scarffe L, Behensky AA, Guiberson N, Chang M, Ma E, Kim JW, Castro CC, Mao X, Chen L, ... ... Dawson TM, et al. Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel. Science Translational Medicine. 9. PMID 29237760 DOI: 10.1126/Scitranslmed.Aah4985  0.676
2017 Hinkle JT, Perepezko K, Rosenthal LS, Mills KA, Pantelyat A, Mari Z, Tochen L, Bang JY, Gudavalli M, Yoritomo N, Butala A, Bakker CC, Johnson V, Moukheiber E, Dawson TM, et al. Markers of impaired motor and cognitive volition in Parkinson's disease: Correlates of dopamine dysregulation syndrome, impulse control disorder, and dyskinesias. Parkinsonism & Related Disorders. PMID 29198499 DOI: 10.1016/J.Parkreldis.2017.11.338  0.378
2017 Brahmachari S, Karuppagounder SS, Ge P, Lee S, Dawson VL, Dawson TM, Ko HS. c-Abl and Parkinson's Disease: Mechanisms and Therapeutic Potential. Journal of Parkinson's Disease. 7: 589-601. PMID 29103051 DOI: 10.3233/Jpd-171191  0.813
2017 Sulzer D, Alcalay RN, Garretti F, Cote L, Kanter E, Agin-Liebes J, Liong C, McMurtrey C, Hildebrand WH, Mao X, Dawson VL, Dawson TM, Oseroff C, Pham J, Sidney J, et al. Erratum: T cells from patients with Parkinson's disease recognize α-synuclein peptides. Nature. 549: 292. PMID 28905919 DOI: 10.1038/nature23896  0.645
2017 McCall MN, Kim MS, Adil M, Patil AH, Lu Y, Mitchell CJ, Leal-Rojas P, Xu J, Kumar M, Dawson VL, Dawson TM, Baras AS, Rosenberg AZ, Arking DE, Burns KH, et al. Toward the human cellular microRNAome. Genome Research. PMID 28877962 DOI: 10.1101/Gr.222067.117  0.582
2017 Panicker N, Dawson VL, Dawson TM. Activation mechanisms of the E3 ubiquitin ligase parkin. The Biochemical Journal. 474: 3075-3086. PMID 28860335 DOI: 10.1042/Bcj20170476  0.781
2017 Fan J, Dawson TM, Dawson VL. Cell Death Mechanisms of Neurodegeneration. Advances in Neurobiology. 15: 403-425. PMID 28674991 DOI: 10.1007/978-3-319-57193-5_16  0.56
2017 Gwinn K, David KK, Swanson-Fischer C, Albin R, Hillaire-Clarke CS, Sieber BA, Lungu C, Bowman FD, Alcalay RN, Babcock D, Dawson TM, Dewey RB, Foroud T, German D, Huang X, et al. Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program. Biomarkers in Medicine. PMID 28644039 DOI: 10.2217/Bmm-2016-0370  0.36
2017 Sulzer D, Alcalay RN, Garretti F, Cote L, Kanter E, Agin-Liebes J, Liong C, McMurtrey C, Hildebrand WH, Mao X, Dawson VL, Dawson TM, Oseroff C, Pham J, Sidney J, et al. T cells from patients with Parkinson's disease recognize α-synuclein peptides. Nature. PMID 28636593 DOI: 10.1038/Nature22815  0.697
2017 Hinkle JT, Perepezko K, Bakker CC, Dawson TM, Johnson V, Mari Z, Marvel CL, Mills KA, Pantelyat A, Pletnikova O, Rosenthal LS, Shepard MD, Stevens DA, Troncoso JC, Wang J, et al. Domain-specific cognitive impairment in non-demented Parkinson's disease psychosis. International Journal of Geriatric Psychiatry. PMID 28509347 DOI: 10.1002/Gps.4736  0.305
2017 Scott L, Dawson VL, Dawson TM. Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson's disease genes. Experimental Neurology. PMID 28445716 DOI: 10.1016/J.Expneurol.2017.04.008  0.606
2017 Ando M, Fiesel FC, Hudec R, Caulfield TR, Ogaki K, Górka-Skoczylas P, Koziorowski D, Friedman A, Chen L, Dawson VL, Dawson TM, Bu G, Ross OA, Wszolek ZK, Springer W. The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity. Molecular Neurodegeneration. 12: 32. PMID 28438176 DOI: 10.1186/S13024-017-0174-Z  0.553
2017 Puschmann A, Fiesel FC, Caulfield TR, Hudec R, Ando M, Truban D, Hou X, Ogaki K, Heckman MG, James ED, Swanberg M, Jimenez-Ferrer I, Hansson O, Opala G, Siuda J, ... ... Dawson TM, et al. Reply: Heterozygous PINK1 p.G411S in rapid eye movement sleep behaviour disorder. Brain : a Journal of Neurology. PMID 28379295 DOI: 10.1093/Brain/Awx077  0.42
2017 Xiong Y, Dawson TM, Dawson VL. Models of LRRK2-Associated Parkinson's Disease. Advances in Neurobiology. 14: 163-191. PMID 28353284 DOI: 10.1007/978-3-319-49969-7_9  0.588
2017 Xiong Y, Neifert S, Karuppagounder SS, Stankowski JN, Lee BD, Grima JC, Chen G, Ko HS, Lee Y, Swing D, Tessarollo L, Dawson TM, Dawson VL. Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology. Eneuro. 4. PMID 28321439 DOI: 10.1523/ENEURO.0004-17.2017  0.828
2017 Berger NA, Besson VC, Boulares AH, Bürkle A, Chiarugi A, Clark RS, Curtin NJ, Cuzzocrea S, Dawson TM, Dawson VL, Haskó G, Liaudet L, Moroni F, Pacher P, Radermacher P, et al. Opportunities for repurposing of poly(ADP-ribose) polymerase (PARP) inhibitors for the therapy of non-oncological diseases. British Journal of Pharmacology. PMID 28213892 DOI: 10.1111/Bph.13748  0.627
2017 Ahrens-Nicklas RC, Umanah GK, Sondheimer N, Deardorff MA, Wilkens AB, Conlin LK, Santani AB, Nesbitt A, Juulsola J, Ma E, Dawson TM, Dawson VL, Marsh ED. Precision therapy for a new disorder of AMPA receptor recycling due to mutations in ATAD1. Neurology. Genetics. 3: e130. PMID 28180185 DOI: 10.1212/Nxg.0000000000000130  0.487
2017 Lee Y, Stevens DA, Kang SU, Jiang H, Lee YI, Ko HS, Scarffe LA, Umanah GE, Kang H, Ham S, Kam TI, Allen K, Brahmachari S, Kim JW, Neifert S, ... ... Dawson TM, et al. PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival. Cell Reports. 18: 918-932. PMID 28122242 DOI: 10.1016/J.Celrep.2016.12.090  0.617
2017 Pignatelli M, Umanah GK, Ribeiro SP, Chen R, Karuppagounder SS, Yau HJ, Eacker S, Dawson VL, Dawson TM, Bonci A. Synaptic Plasticity onto Dopamine Neurons Shapes Fear Learning. Neuron. 93: 425-440. PMID 28103482 DOI: 10.1016/J.Neuron.2016.12.030  0.787
2017 Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Münch AE, Chung WS, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, ... ... Dawson TM, et al. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. PMID 28099414 DOI: 10.1038/Nature21029  0.756
2017 Dawson TM, Dawson VL. Mitochondrial Mechanisms of Neuronal Cell Death: Potential Therapeutics. Annual Review of Pharmacology and Toxicology. 57: 437-454. PMID 28061689 DOI: 10.1146/Annurev-Pharmtox-010716-105001  0.543
2016 Wang Y, An R, Umanah GK, Park H, Nambiar K, Eacker SM, Kim B, Bao L, Harraz MM, Chang C, Chen R, Wang JE, Kam TI, Jeong JS, Xie Z, ... ... Dawson TM, et al. A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1. Science (New York, N.Y.). 354. PMID 27846469 DOI: 10.1126/Science.Aad6872  0.799
2016 Zhang J, Wang H, Sherbini O, Ling-Lin Pai E, Kang SU, Kwon JS, Yang J, He W, Wang H, Eacker SM, Chi Z, Mao X, Xu J, Jiang H, Andrabi SA, ... Dawson TM, et al. High-Content Genome-Wide RNAi Screen Reveals CCR3 as a Key Mediator of Neuronal Cell Death. Eneuro. 3. PMID 27822494 DOI: 10.1523/ENEURO.0185-16.2016  0.803
2016 Puschmann A, Fiesel FC, Caulfield TR, Hudec R, Ando M, Truban D, Hou X, Ogaki K, Heckman MG, James ED, Swanberg M, Jimenez-Ferrer I, Hansson O, Opala G, Siuda J, ... ... Dawson TM, et al. Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism. Brain : a Journal of Neurology. PMID 27807026 DOI: 10.1093/Brain/Aww261  0.538
2016 Mao X, Ou MT, Karuppagounder SS, Kam TI, Yin X, Xiong Y, Ge P, Umanah GE, Brahmachari S, Shin JH, Kang HC, Zhang J, Xu J, Chen R, Park H, ... ... Dawson TM, et al. Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3. Science (New York, N.Y.). 353. PMID 27708076 DOI: 10.1126/Science.Aah3374  0.806
2016 Mills KA, Mari Z, Bakker C, Johnson V, Pontone GM, Pantelyat A, Troncoso JC, Pletnikova O, Dawson TM, Rosenthal LS. Gait function and locus coeruleus Lewy body pathology in 51 Parkinson's disease patients. Parkinsonism & Related Disorders. PMID 27693194 DOI: 10.1016/J.Parkreldis.2016.09.024  0.407
2016 Jiang H, Kang SU, Zhang S, Karuppagounder S, Xu J, Lee YK, Kang BG, Lee Y, Zhang J, Pletnikova O, Troncoso JC, Pirooznia S, Andrabi SA, Dawson VL, Dawson TM. Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons. Eneuro. 3. PMID 27622213 DOI: 10.1523/ENEURO.0183-16.2016  0.83
2016 Davis MY, Johnson CO, Leverenz JB, Weintraub D, Trojanowski JQ, Chen-Plotkin A, Van Deerlin VM, Quinn JF, Chung KA, Peterson-Hiller AL, Rosenthal LS, Dawson TM, Albert MS, Goldman JG, Stebbins GT, et al. Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease. Jama Neurology. PMID 27571329 DOI: 10.1001/Jamaneurol.2016.2245  0.37
2016 Zhang J, Li X, Kwansa H, Kim YT, Yi L, Hong G, Andrabi SA, Dawson VL, Dawson TM, Koehler RC, Yang ZJ. Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 27381826 DOI: 10.1177/0271678X16658491  0.521
2016 Brahmachari S, Ge P, Lee SH, Kim D, Karuppagounder SS, Kumar M, Mao X, Lee Y, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Ko HS. Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration. The Journal of Clinical Investigation. PMID 27348587 DOI: 10.1172/Jci85456  0.807
2016 Nucifora FC, Nucifora LG, Ng CH, Arbez N, Guo Y, Roby E, Shani V, Engelender S, Wei D, Wang XF, Li T, Moore DJ, Pletnikova O, Troncoso JC, Sawa A, ... Dawson TM, et al. Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1. Nature Communications. 7: 11792. PMID 27273569 DOI: 10.1038/Ncomms11792  0.772
2016 Xu JC, Fan J, Wang X, Eacker SM, Kam TI, Chen L, Yin X, Zhu J, Chi Z, Jiang H, Chen R, Dawson TM, Dawson VL. Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity. Science Translational Medicine. 8: 333ra48. PMID 27053772 DOI: 10.1126/Scitranslmed.Aad0623  0.806
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin J, Abeliovich H, Arozena AA, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Dawson TM, et al. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 Autophagy. 12: 443-443. PMID 26902590 DOI: 10.1080/15548627.2016.1147886  0.761
2016 Martin I, Kim JW, Dawson VL, Dawson TM. LRRK2 pathobiology in Parkinson's disease - virtual inclusion. Journal of Neurochemistry. PMID 26899799 DOI: 10.1111/Jnc.13549  0.659
2016 Karuppagounder SS, Xiong Y, Lee Y, Lawless MC, Kim D, Nordquist E, Martin I, Ge P, Brahmachari S, Jhaldiyal A, Kumar M, Andrabi SA, Dawson TM, Dawson VL. LRRK2 G2019S Transgenic Mice Display Increased Susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-Mediated Neurotoxicity. Journal of Chemical Neuroanatomy. PMID 26808467 DOI: 10.1016/J.Jchemneu.2016.01.007  0.811
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Dawson TM, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.779
2016 Philippens IHCHM, Franke SK, Kesteren REv, Hofman S, Wubben JAM, Smit AB, Moldovan A, Südmeyer M, Hammesfahr S, Antke C, Mamlins E, Beu M, Wojtecki L, Ferrea S, Schnitzler A, ... ... Dawson TM, et al. Contents Vol. 16, 2016 Neurodegenerative Diseases. 16. DOI: 10.1159/000448958  0.536
2016 Wang Y, An R, Umanah GK, Park H, Nambiar K, Eacker SM, Kim B, Bao L, Harraz MM, Chang C, Chen R, Wang JE, Kam TI, Jeong JS, Xie Z, ... ... Dawson TM, et al. A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1 Science. 354. DOI: 10.1126/science.aad6872  0.799
2016 Kutten KS, Eacker SM, Dawson VL, Dawson TM, Ratnanather T, Miller MI. An image registration pipeline for analysis of transsynaptic tracing in mice Progress in Biomedical Optics and Imaging - Proceedings of Spie. 9788. DOI: 10.1117/12.2216233  0.796
2015 Choi S, Kim D, Kam TI, Yun S, Kim S, Park H, Hwang H, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Ko HS. Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity. Plos One. 10: e0143854. PMID 26629917 DOI: 10.1371/Journal.Pone.0143854  0.566
2015 Lee Y, Karuppagounder SS, Shin JH, Lee YI, Ko HS, Swing D, Jiang H, Kang SU, Lee BD, Kang HC, Kim D, Tessarollo L, Dawson VL, Dawson TM. Corrigendum: Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss. Nature Neuroscience. 18: 1861. PMID 26605883 DOI: 10.1038/Nn1215-1861A  0.804
2015 Nam JH, Park ES, Won SY, Lee YA, Kim KI, Jeong JY, Baek JY, Cho EJ, Jin M, Chung YC, Lee BD, Kim SH, Kim EG, Byun K, Lee B, ... ... Dawson TM, et al. TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson's disease via CNTF. Brain : a Journal of Neurology. PMID 26490328 DOI: 10.1093/Brain/Awv297  0.601
2015 Rosenthal LS, Drake D, Alcalay RN, Babcock D, Bowman FD, Chen-Plotkin A, Dawson TM, Dewey RB, German DC, Huang X, Landin B, McAuliffe M, Petyuk VA, Scherzer CR, Hillaire-Clarke CS, et al. The NINDS Parkinson's disease biomarkers program. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 26442452 DOI: 10.1002/Mds.26438  0.368
2015 Stevens DA, Lee Y, Kang HC, Lee BD, Lee YI, Bower A, Jiang H, Kang SU, Andrabi SA, Dawson VL, Shin JH, Dawson TM. Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration. Proceedings of the National Academy of Sciences of the United States of America. 112: 11696-701. PMID 26324925 DOI: 10.1073/Pnas.1500624112  0.565
2015 Mata IF, Leverenz JB, Weintraub D, Trojanowski JQ, Chen-Plotkin A, Van Deerlin VM, Ritz B, Rausch R, Factor SA, Wood-Siverio C, Quinn JF, Chung KA, Peterson-Hiller AL, Goldman JG, Stebbins GT, ... ... Dawson TM, et al. GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 26296077 DOI: 10.1002/Mds.26359  0.331
2015 Fiesel FC, Ando M, Hudec R, Hill AR, Castanedes-Casey M, Caulfield TR, Moussaud-Lamodière EL, Stankowski JN, Bauer PO, Lorenzo-Betancor O, Ferrer I, Arbelo JM, Siuda J, Chen L, Dawson VL, ... Dawson TM, et al. (Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation. Embo Reports. PMID 26162776 DOI: 10.15252/Embr.201540514  0.593
2015 Beecham GW, Dickson DW, Scott WK, Martin ER, Schellenberg G, Nuytemans K, Larson EB, Buxbaum JD, Trojanowski JQ, Van Deerlin VM, Hurtig HI, Mash DC, Beach TG, Troncoso JC, Pletnikova O, ... ... Dawson TM, et al. PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease. Neurology. 84: 972-80. PMID 25663231 DOI: 10.1212/Wnl.0000000000001332  0.384
2015 Srivatsal S, Cholerton B, Leverenz JB, Wszolek ZK, Uitti RJ, Dickson DW, Weintraub D, Trojanowski JQ, Van Deerlin VM, Quinn JF, Chung KA, Peterson AL, Factor SA, Wood-Siverio C, Goldman JG, ... ... Dawson TM, et al. Cognitive profile of LRRK2-related Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 728-33. PMID 25650144 DOI: 10.1002/Mds.26161  0.371
2015 Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, ... ... Dawson TM, et al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death and Differentiation. 22: 58-73. PMID 25236395 DOI: 10.1038/Cdd.2014.137  0.504
2014 Martin I, Abalde-Atristain L, Kim JW, Dawson TM, Dawson VL. Abberant protein synthesis in G2019S LRRK2 Drosophila Parkinson disease-related phenotypes. Fly. 8: 165-9. PMID 25483009 DOI: 10.4161/19336934.2014.983382  0.824
2014 Harraz MM, Xu JC, Guiberson N, Dawson TM, Dawson VL. MiR-223 regulates the differentiation of immature neurons. Molecular and Cellular Therapies. 2. PMID 25400937  0.757
2014 Kageyama Y, Hoshijima M, Seo K, Bedja D, Sysa-Shah P, Andrabi SA, Chen W, Höke A, Dawson VL, Dawson TM, Gabrielson K, Kass DA, Iijima M, Sesaki H. Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain. The Embo Journal. 33: 2798-813. PMID 25349190 DOI: 10.15252/Embj.201488658  0.515
2014 Prendergast J, Umanah GK, Yoo SW, Lagerlöf O, Motari MG, Cole RN, Huganir RL, Dawson TM, Dawson VL, Schnaar RL. Ganglioside regulation of AMPA receptor trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 13246-58. PMID 25253868 DOI: 10.1523/Jneurosci.1149-14.2014  0.543
2014 Martin I, Kim JW, Dawson VL, Dawson TM. LRRK2 pathobiology in Parkinson's disease. Journal of Neurochemistry. 131: 554-65. PMID 25251388 DOI: 10.1111/Jnc.12949  0.695
2014 Siuda J, Jasinska-Myga B, Boczarska-Jedynak M, Opala G, Fiesel FC, Moussaud-Lamodière EL, Scarffe LA, Dawson VL, Ross OA, Springer W, Dawson TM, Wszolek ZK. Early-onset Parkinson's disease due to PINK1 p.Q456X mutation--clinical and functional study. Parkinsonism & Related Disorders. 20: 1274-8. PMID 25226871 DOI: 10.1016/J.Parkreldis.2014.08.019  0.598
2014 Lu W, Karuppagounder SS, Springer DA, Allen MD, Zheng L, Chao B, Zhang Y, Dawson VL, Dawson TM, Lenardo M. Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson's-like movement disorder. Nature Communications. 5: 4930. PMID 25222142 DOI: 10.1038/Ncomms5930  0.813
2014 Tsika E, Kannan M, Foo CS, Dikeman D, Glauser L, Gellhaar S, Galter D, Knott GW, Dawson TM, Dawson VL, Moore DJ. Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration. Neurobiology of Disease. 71: 345-58. PMID 25174890 DOI: 10.1016/J.Nbd.2014.08.027  0.621
2014 Andrabi SA, Umanah GK, Chang C, Stevens DA, Karuppagounder SS, Gagné JP, Poirier GG, Dawson VL, Dawson TM. Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis. Proceedings of the National Academy of Sciences of the United States of America. 111: 10209-14. PMID 24987120 DOI: 10.1073/Pnas.1405158111  0.807
2014 Sagal J, Zhan X, Xu J, Tilghman J, Karuppagounder SS, Chen L, Dawson VL, Dawson TM, Laterra J, Ying M. Proneural transcription factor Atoh1 drives highly efficient differentiation of human pluripotent stem cells into dopaminergic neurons. Stem Cells Translational Medicine. 3: 888-98. PMID 24904172 DOI: 10.5966/Sctm.2013-0213  0.825
2014 Chen YC, Umanah GK, Dephoure N, Andrabi SA, Gygi SP, Dawson TM, Dawson VL, Rutter J. Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins. The Embo Journal. 33: 1548-64. PMID 24843043 DOI: 10.15252/Embj.201487943  0.499
2014 Karuppagounder SS, Brahmachari S, Lee Y, Dawson VL, Dawson TM, Ko HS. The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease. Scientific Reports. 4: 4874. PMID 24786396 DOI: 10.1038/Srep04874  0.834
2014 Chi Z, Byrne ST, Dolinko A, Harraz MM, Kim MS, Umanah G, Zhong J, Chen R, Zhang J, Xu J, Chen L, Pandey A, Dawson TM, Dawson VL. Botch is a γ-glutamyl cyclotransferase that deglycinates and antagonizes Notch. Cell Reports. 7: 681-8. PMID 24767995 DOI: 10.1016/J.Celrep.2014.03.048  0.786
2014 Scarffe LA, Stevens DA, Dawson VL, Dawson TM. Parkin and PINK1: much more than mitophagy. Trends in Neurosciences. 37: 315-24. PMID 24735649 DOI: 10.1016/J.Tins.2014.03.004  0.574
2014 Martin I, Kim JW, Lee BD, Kang HC, Xu JC, Jia H, Stankowski J, Kim MS, Zhong J, Kumar M, Andrabi SA, Xiong Y, Dickson DW, Wszolek ZK, Pandey A, ... Dawson TM, et al. Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease. Cell. 157: 472-85. PMID 24725412 DOI: 10.1016/J.Cell.2014.01.064  0.76
2014 Fatokun AA, Dawson VL, Dawson TM. Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities. British Journal of Pharmacology. 171: 2000-16. PMID 24684389 DOI: 10.1111/Bph.12416  0.541
2014 Beal MF, Oakes D, Shoulson I, Henchcliffe C, Galpern WR, Haas R, Juncos JL, Nutt JG, Voss TS, Ravina B, Shults CM, Helles K, Snively V, Lew MF, ... ... Dawson TM, et al. A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. Jama Neurology. 71: 543-52. PMID 24664227 DOI: 10.1001/Jamaneurol.2014.131  0.314
2014 Xiao J, Li Y, Prandovszky E, Karuppagounder SS, Talbot CC, Dawson VL, Dawson TM, Yolken RH. MicroRNA-132 dysregulation in Toxoplasma gondii infection has implications for dopamine signaling pathway. Neuroscience. 268: 128-38. PMID 24657774 DOI: 10.1016/J.Neuroscience.2014.03.015  0.782
2014 Pirooznia SK, Dawson VL, Dawson TM. Motor neuron death in ALS: programmed by astrocytes? Neuron. 81: 961-3. PMID 24607221 DOI: 10.1016/J.Neuron.2014.02.024  0.513
2014 Nuytemans K, Inchausti V, Beecham GW, Wang L, Dickson DW, Trojanowski JQ, Lee VM, Mash DC, Frosch MP, Foroud TM, Honig LS, Montine TJ, Dawson TM, Martin ER, Scott WK, et al. Absence of C9ORF72 expanded or intermediate repeats in autopsy-confirmed Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 29: 827-30. PMID 24573903 DOI: 10.1002/Mds.25838  0.385
2014 Stafa K, Tsika E, Moser R, Musso A, Glauser L, Jones A, Biskup S, Xiong Y, Bandopadhyay R, Dawson VL, Dawson TM, Moore DJ. Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily. Human Molecular Genetics. 23: 2055-77. PMID 24282027 DOI: 10.1093/Hmg/Ddt600  0.592
2014 Lee YI, Giovinazzo D, Kang HC, Lee Y, Jeong JS, Doulias PT, Xie Z, Hu J, Ghasemi M, Ischiropoulos H, Qian J, Zhu H, Blackshaw S, Dawson VL, Dawson TM. Protein microarray characterization of the S-nitrosoproteome. Molecular & Cellular Proteomics : McP. 13: 63-72. PMID 24105792 DOI: 10.1074/Mcp.M113.032235  0.778
2014 Dawson TM, Dawson VL. Parkin plays a role in sporadic Parkinson's disease. Neuro-Degenerative Diseases. 13: 69-71. PMID 24029689 DOI: 10.1159/000354307  0.575
2013 Migheli R, Del Giudice MG, Spissu Y, Sanna G, Xiong Y, Dawson TM, Dawson VL, Galioto M, Rocchitta G, Biosa A, Serra PA, Carri MT, Crosio C, Iaccarino C. LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization. Plos One. 8: e77198. PMID 24167564 DOI: 10.1371/Journal.Pone.0077198  0.584
2013 Xu JC, Dawson VL, Dawson TM. Usp16: key controller of stem cells in Down syndrome. The Embo Journal. 32: 2788-9. PMID 24076652 DOI: 10.1038/Emboj.2013.220  0.569
2013 Brundin P, Barker RA, Conn PJ, Dawson TM, Kieburtz K, Lees AJ, Schwarzschild MA, Tanner CM, Isaacs T, Duffen J, Matthews H, Wyse RK. Linked clinical trials--the development of new clinical learning studies in Parkinson's disease using screening of multiple prospective new treatments. Journal of Parkinson's Disease. 3: 231-9. PMID 24018336 DOI: 10.3233/Jpd-139000  0.344
2013 Eacker SM, Dawson TM, Dawson VL. The interplay of microRNA and neuronal activity in health and disease. Frontiers in Cellular Neuroscience. 7: 136. PMID 23986658 DOI: 10.3389/Fncel.2013.00136  0.77
2013 Lee Y, Karuppagounder SS, Shin JH, Lee YI, Ko HS, Swing D, Jiang H, Kang SU, Lee BD, Kang HC, Kim D, Tessarollo L, Dawson VL, Dawson TM. Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss. Nature Neuroscience. 16: 1392-400. PMID 23974709 DOI: 10.1038/Nn.3500  0.839
2013 Fatokun AA, Liu JO, Dawson VL, Dawson TM. Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos. British Journal of Pharmacology. 169: 1263-78. PMID 23550801 DOI: 10.1111/Bph.12201  0.538
2013 Vandiver MS, Paul BD, Xu R, Karuppagounder S, Rao F, Snowman AM, Ko HS, Lee YI, Dawson VL, Dawson TM, Sen N, Snyder SH. Sulfhydration mediates neuroprotective actions of parkin. Nature Communications. 4: 1626. PMID 23535647 DOI: 10.1038/Ncomms2623  0.807
2013 Krietsch J, Rouleau M, Pic É, Ethier C, Dawson TM, Dawson VL, Masson JY, Poirier GG, Gagné JP. Reprogramming cellular events by poly(ADP-ribose)-binding proteins. Molecular Aspects of Medicine. 34: 1066-87. PMID 23268355 DOI: 10.1016/J.Mam.2012.12.005  0.494
2013 Calabresi P, Di Filippo M, Gallina A, Wang Y, Stankowski JN, Picconi B, Dawson VL, Dawson TM. New synaptic and molecular targets for neuroprotection in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 51-60. PMID 22927178 DOI: 10.1002/Mds.25096  0.606
2012 Ahmed I, Liang Y, Schools S, Dawson VL, Dawson TM, Savitt JM. Development and characterization of a new Parkinson's disease model resulting from impaired autophagy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 16503-9. PMID 23152632 DOI: 10.1523/Jneurosci.0209-12.2012  0.617
2012 Harraz MM, Eacker SM, Wang X, Dawson TM, Dawson VL. MicroRNA-223 is neuroprotective by targeting glutamate receptors. Proceedings of the National Academy of Sciences of the United States of America. 109: 18962-7. PMID 23112146 DOI: 10.1073/Pnas.1121288109  0.792
2012 Xiong Y, Dawson VL, Dawson TM. LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease. Biochemical Society Transactions. 40: 1074-9. PMID 22988868 DOI: 10.1042/Bst20120093  0.565
2012 Lee Y, Dawson VL, Dawson TM. Animal models of Parkinson's disease: vertebrate genetics. Cold Spring Harbor Perspectives in Medicine. 2. PMID 22960626 DOI: 10.1101/Cshperspect.A009324  0.564
2012 Wray S, Self M, Lewis PA, Taanman JW, Ryan NS, Mahoney CJ, Liang Y, Devine MJ, Sheerin UM, Houlden H, Morris HR, Healy D, ... ... Dawson TM, et al. Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. Plos One. 7: e43099. PMID 22952635 DOI: 10.1371/Journal.Pone.0043099  0.322
2012 Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, ... ... Dawson TM, et al. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Science Translational Medicine. 4: 141ra90. PMID 22764206 DOI: 10.1126/Scitranslmed.3003985  0.583
2012 Lee BD, Dawson VL, Dawson TM. Leucine-rich repeat kinase 2 (LRRK2) as a potential therapeutic target in Parkinson's disease. Trends in Pharmacological Sciences. 33: 365-73. PMID 22578536 DOI: 10.1016/J.Tips.2012.04.001  0.588
2012 Chi Z, Zhang J, Tokunaga A, Harraz MM, Byrne ST, Dolinko A, Xu J, Blackshaw S, Gaiano N, Dawson TM, Dawson VL. Botch promotes neurogenesis by antagonizing Notch. Developmental Cell. 22: 707-20. PMID 22445366 DOI: 10.1016/J.Devcel.2012.02.011  0.795
2012 Xiong Y, Yuan C, Chen R, Dawson TM, Dawson VL. ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3877-86. PMID 22423108 DOI: 10.1523/Jneurosci.4566-11.2012  0.555
2012 Daher JP, Pletnikova O, Biskup S, Musso A, Gellhaar S, Galter D, Troncoso JC, Lee MK, Dawson TM, Dawson VL, Moore DJ. Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2. Human Molecular Genetics. 21: 2420-31. PMID 22357653 DOI: 10.1093/Hmg/Dds057  0.609
2012 Stankowski JN, Dawson VL, Dawson TM. Ironing out tau's role in parkinsonism. Nature Medicine. 18: 197-8. PMID 22310680 DOI: 10.1038/Nm.2668  0.539
2012 Nikonova EV, Xiong Y, Tanis KQ, Dawson VL, Vogel RL, Finney EM, Stone DJ, Reynolds IJ, Kern JT, Dawson TM. Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity. Human Molecular Genetics. 21: 163-74. PMID 21972245 DOI: 10.1093/Hmg/Ddr451  0.696
2012 Lee BD, Li X, Dawson TM, Dawson VL. Measuring the activity of leucine-rich repeat kinase 2: a kinase involved in Parkinson's disease. Methods in Molecular Biology (Clifton, N.J.). 795: 45-54. PMID 21960214 DOI: 10.1007/978-1-61779-337-0_3  0.622
2012 Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S, Gottlieb E, Green DR, Hengartner MO, Kepp O, Knight RA, et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death and Differentiation. 19: 107-20. PMID 21760595 DOI: 10.1038/cdd.2011.96  0.413
2012 Thomas B, Mandir AS, West N, Liu Y, Andrabi SA, Stirling W, Dawson VL, Dawson TM, Lee MK. Correction: Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation Plos One. 7. DOI: 10.1371/annotation/f743434e-a6bf-4c6c-a836-ae5af66035a4  0.439
2011 Eacker SM, Keuss MJ, Berezikov E, Dawson VL, Dawson TM. Neuronal activity regulates hippocampal miRNA expression. Plos One. 6: e25068. PMID 21984899 DOI: 10.1371/Journal.Pone.0025068  0.759
2011 Kang HC, Lee YI, Shin JH, Andrabi SA, Chi Z, Gagné JP, Lee Y, Ko HS, Lee BD, Poirier GG, Dawson VL, Dawson TM. Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage. Proceedings of the National Academy of Sciences of the United States of America. 108: 14103-8. PMID 21825151 DOI: 10.1073/Pnas.1108799108  0.502
2011 Ramsden N, Perrin J, Ren Z, Lee BD, Zinn N, Dawson VL, Tam D, Bova M, Lang M, Drewes G, Bantscheff M, Bard F, Dawson TM, Hopf C. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. Acs Chemical Biology. 6: 1021-8. PMID 21812418 DOI: 10.1021/Cb2002413  0.574
2011 Chew KC, Ang ET, Tai YK, Tsang F, Lo SQ, Ong E, Ong WY, Shen HM, Lim KL, Dawson VL, Dawson TM, Soong TW. Enhanced autophagy from chronic toxicity of iron and mutant A53T α-synuclein: implications for neuronal cell death in Parkinson disease. The Journal of Biological Chemistry. 286: 33380-9. PMID 21795716 DOI: 10.1074/Jbc.M111.268409  0.727
2011 Liu Z, Hamamichi S, Lee BD, Yang D, Ray A, Caldwell GA, Caldwell KA, Dawson TM, Smith WW, Dawson VL. Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models. Human Molecular Genetics. 20: 3933-42. PMID 21768216 DOI: 10.1093/Hmg/Ddr312  0.595
2011 Dawson TM, Dawson VL. A lysosomal lair for a pathogenic protein pair. Science Translational Medicine. 3: 91ps28. PMID 21753118 DOI: 10.1126/Scitranslmed.3002808  0.583
2011 Martin I, Dawson VL, Dawson TM. Recent advances in the genetics of Parkinson's disease. Annual Review of Genomics and Human Genetics. 12: 301-25. PMID 21639795 DOI: 10.1146/Annurev-Genom-082410-101440  0.677
2011 Andrabi SA, Kang HC, Haince JF, Lee YI, Zhang J, Chi Z, West AB, Koehler RC, Poirier GG, Dawson TM, Dawson VL. Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death. Nature Medicine. 17: 692-9. PMID 21602803 DOI: 10.1038/Nm.2387  0.507
2011 Zhang J, Wang Y, Chi Z, Keuss MJ, Pai YM, Kang HC, Shin JH, Bugayenko A, Wang H, Xiong Y, Pletnikov MV, Mattson MP, Dawson TM, Dawson VL. The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior. Cell. 145: 284-99. PMID 21496646 DOI: 10.1016/J.Cell.2011.03.016  0.558
2011 Ramonet D, Daher JP, Lin BM, Stafa K, Kim J, Banerjee R, Westerlund M, Pletnikova O, Glauser L, Yang L, Liu Y, Swing DA, Beal MF, Troncoso JC, McCaffery JM, ... ... Dawson TM, et al. Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. Plos One. 6: e18568. PMID 21494637 DOI: 10.1371/Journal.Pone.0018568  0.611
2011 Wang Y, Kim NS, Haince JF, Kang HC, David KK, Andrabi SA, Poirier GG, Dawson VL, Dawson TM. Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos). Science Signaling. 4: ra20. PMID 21467298 DOI: 10.1126/Scisignal.2000902  0.523
2011 Shin JH, Ko HS, Kang H, Lee Y, Lee YI, Pletinkova O, Troconso JC, Dawson VL, Dawson TM. PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease. Cell. 144: 689-702. PMID 21376232 DOI: 10.1016/J.Cell.2011.02.010  0.624
2011 Thomas B, Mandir AS, West N, Liu Y, Andrabi SA, Stirling W, Dawson VL, Dawson TM, Lee MK. Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation. Plos One. 6: e16706. PMID 21304957 DOI: 10.1371/Journal.Pone.0016706  0.6
2011 Harraz MM, Dawson TM, Dawson VL. MicroRNAs in Parkinson's disease. Journal of Chemical Neuroanatomy. 42: 127-30. PMID 21295133 DOI: 10.1016/J.Jchemneu.2011.01.005  0.764
2011 Dawson VL, Dawson TM. Intracellular Signaling: Mediators and Protective Responses Stroke. 154-161. DOI: 10.1016/B978-1-4160-5478-8.10010-7  0.378
2011 Xu J, Dawson TM. A perfect “Match” for in vitro human disease modeling and autologous cell-based transplantation therapy: Generating genetically identical Parkinson's disease and control pluripotent stem cells by precise gene targeting Movement Disorders. 26: 1804-1804. DOI: 10.1002/Mds.23924  0.31
2010 Dai C, Liang D, Li H, Sasaki M, Dawson TM, Dawson VL. Functional identification of neuroprotective molecules. Plos One. 5: e15008. PMID 21124846 DOI: 10.1371/Journal.Pone.0015008  0.529
2010 Ko HS, Lee Y, Shin JH, Karuppagounder SS, Gadad BS, Koleske AJ, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM. Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function. Proceedings of the National Academy of Sciences of the United States of America. 107: 16691-6. PMID 20823226 DOI: 10.1073/Pnas.1006083107  0.819
2010 Lee BD, Shin JH, VanKampen J, Petrucelli L, West AB, Ko HS, Lee YI, Maguire-Zeiss KA, Bowers WJ, Federoff HJ, Dawson VL, Dawson TM. Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nature Medicine. 16: 998-1000. PMID 20729864 DOI: 10.1038/Nm.2199  0.558
2010 Martin I, Dawson VL, Dawson TM. The impact of genetic research on our understanding of Parkinson's disease. Progress in Brain Research. 183: 21-41. PMID 20696313 DOI: 10.1016/S0079-6123(10)83002-X  0.677
2010 Li X, Moore DJ, Xiong Y, Dawson TM, Dawson VL. Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2. The Journal of Biological Chemistry. 285: 29569-76. PMID 20595391 DOI: 10.1074/Jbc.M110.127639  0.619
2010 Dawson TM, Ko HS, Dawson VL. Genetic animal models of Parkinson's disease. Neuron. 66: 646-61. PMID 20547124 DOI: 10.1016/J.Neuron.2010.04.034  0.578
2010 Zheng S, Eacker SM, Hong SJ, Gronostajski RM, Dawson TM, Dawson VL. NMDA-induced neuronal survival is mediated through nuclear factor I-A in mice. The Journal of Clinical Investigation. 120: 2446-56. PMID 20516644 DOI: 10.1172/Jci33144  0.806
2010 Xu Z, Zhang J, David KK, Yang ZJ, Li X, Dawson TM, Dawson VL, Koehler RC. Endonuclease G does not play an obligatory role in poly(ADP-ribose) polymerase-dependent cell death after transient focal cerebral ischemia. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 299: R215-21. PMID 20427721 DOI: 10.1152/Ajpregu.00747.2009  0.488
2010 Xiong Y, Coombes CE, Kilaru A, Li X, Gitler AD, Bowers WJ, Dawson VL, Dawson TM, Moore DJ. GTPase activity plays a key role in the pathobiology of LRRK2. Plos Genetics. 6: e1000902. PMID 20386743 DOI: 10.1371/Journal.Pgen.1000902  0.68
2010 Li X, Klaus JA, Zhang J, Xu Z, Kibler KK, Andrabi SA, Rao K, Yang ZJ, Dawson TM, Dawson VL, Koehler RC. Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia. Journal of Neurochemistry. 113: 1012-22. PMID 20236222 DOI: 10.1111/J.1471-4159.2010.06667.X  0.515
2010 Dawson TM, Dawson VL. The role of parkin in familial and sporadic Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 25: S32-9. PMID 20187240 DOI: 10.1002/Mds.22798  0.582
2010 Smith WW, Liu Z, Liang Y, Masuda N, Swing DA, Jenkins NA, Copeland NG, Troncoso JC, Pletnikov M, Dawson TM, Martin LJ, Moran TH, Lee MK, Borchelt DR, Ross CA. Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model. Human Molecular Genetics. 19: 2087-98. PMID 20185556 DOI: 10.1093/Hmg/Ddq086  0.548
2010 Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RL, Kim J, May J, Tocilescu MA, Liu W, Ko HS, Magrané J, Moore DJ, Dawson VL, Grailhe R, Dawson TM, et al. PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proceedings of the National Academy of Sciences of the United States of America. 107: 378-83. PMID 19966284 DOI: 10.1073/Pnas.0911187107  0.527
2010 Lee YI, Dawson TM, Dawson VL. Role of no in neurodegeneration Encyclopedia of Neuroscience. 415-420. DOI: 10.1016/B978-008045046-9.00526-X  0.404
2010 Kang HC, Dawson TM, Dawson VL. Excitotoxic programmed cell death involves caspase-independent mechanisms Acute Neuronal Injury: the Role of Excitotoxic Programmed Cell Death Mechanisms. 79-88. DOI: 10.1007/978-0-387-73226-8_5  0.394
2009 Andres-Mateos E, Mejias R, Sasaki M, Li X, Lin BM, Biskup S, Zhang L, Banerjee R, Thomas B, Yang L, Liu G, Beal MF, Huso DL, Dawson TM, Dawson VL. Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 15846-50. PMID 20016100 DOI: 10.1523/Jneurosci.4357-09.2009  0.681
2009 Eacker SM, Dawson TM, Dawson VL. Understanding microRNAs in neurodegeneration. Nature Reviews. Neuroscience. 10: 837-41. PMID 19904280 DOI: 10.1038/Nrn2726  0.763
2009 Yu SW, Wang Y, Frydenlund DS, Ottersen OP, Dawson VL, Dawson TM. Outer mitochondrial membrane localization of apoptosis-inducing factor: mechanistic implications for release. Asn Neuro. 1. PMID 19863494 DOI: 10.1042/An20090046  0.515
2009 Shin JH, Dawson VL, Dawson TM. SnapShot: pathogenesis of Parkinson's disease. Cell. 139: 440.e1-2. PMID 19837042 DOI: 10.1016/J.Cell.2009.09.026  0.586
2009 Ng CH, Mok SZ, Koh C, Ouyang X, Fivaz ML, Tan EK, Dawson VL, Dawson TM, Yu F, Lim KL. Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 11257-62. PMID 19741132 DOI: 10.1523/Jneurosci.2375-09.2009  0.722
2009 Higashi S, Moore DJ, Yamamoto R, Minegishi M, Sato K, Togo T, Katsuse O, Uchikado H, Furukawa Y, Hino H, Kosaka K, Emson PC, Wada K, Dawson VL, Dawson TM, et al. Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease. Journal of Neuropathology and Experimental Neurology. 68: 994-1005. PMID 19680143 DOI: 10.1097/Nen.0B013E3181B44Ed8  0.516
2009 Daher JP, Ying M, Banerjee R, McDonald RS, Hahn MD, Yang L, Flint Beal M, Thomas B, Dawson VL, Dawson TM, Moore DJ. Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons. Molecular Neurodegeneration. 4: 34. PMID 19630976 DOI: 10.1186/1750-1326-4-34  0.588
2009 Hoang T, Choi DK, Nagai M, Wu DC, Nagata T, Prou D, Wilson GL, Vila M, Jackson-Lewis V, Dawson VL, Dawson TM, Chesselet MF, Przedborski S. Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease. Free Radical Biology & Medicine. 47: 1049-56. PMID 19616617 DOI: 10.1016/J.Freeradbiomed.2009.07.013  0.567
2009 Waxman EA, Covy JP, Bukh I, Li X, Dawson TM, Giasson BI. Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions. Journal of Neuropathology and Experimental Neurology. 68: 785-96. PMID 19535993 DOI: 10.1097/Nen.0B013E3181Aaf4Fd  0.462
2009 Wang Y, Kim NS, Li X, Greer PA, Koehler RC, Dawson VL, Dawson TM. Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos). Journal of Neurochemistry. 110: 687-96. PMID 19457082 DOI: 10.1111/J.1471-4159.2009.06167.X  0.513
2009 Wang Y, Dawson VL, Dawson TM. Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos. Experimental Neurology. 218: 193-202. PMID 19332058 DOI: 10.1016/J.Expneurol.2009.03.020  0.508
2009 Tsang AH, Lee YI, Ko HS, Savitt JM, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Chung KK. S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 106: 4900-5. PMID 19273858 DOI: 10.1073/Pnas.0810595106  0.607
2009 David KK, Andrabi SA, Dawson TM, Dawson VL. Parthanatos, a messenger of death. Frontiers in Bioscience (Landmark Edition). 14: 1116-28. PMID 19273119 DOI: 10.2741/3297  0.514
2009 Ko HS, Bailey R, Smith WW, Liu Z, Shin JH, Lee YI, Zhang YJ, Jiang H, Ross CA, Moore DJ, Patterson C, Petrucelli L, Dawson TM, Dawson VL. CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity. Proceedings of the National Academy of Sciences of the United States of America. 106: 2897-902. PMID 19196961 DOI: 10.1073/Pnas.0810123106  0.664
2009 Tsang AHK, Lee YI, Han SK, Savitt JM, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Chung KKK. S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease (Proceedings of the National Academy of Sciences of the United States of America (2009) 106, 12, (4900-4905) DOI: 10.1073/pnas.0810595106) Proceedings of the National Academy of Sciences of the United States of America. 106: 8791. DOI: 10.1073/Pnas.0903257106  0.539
2008 Gupta A, Dawson VL, Dawson TM. What causes cell death in Parkinson's disease? Annals of Neurology. 64: S3-15. PMID 19127586 DOI: 10.1002/Ana.21573  0.568
2008 Andrabi SA, Dawson TM, Dawson VL. Mitochondrial and nuclear cross talk in cell death: parthanatos. Annals of the New York Academy of Sciences. 1147: 233-41. PMID 19076445 DOI: 10.1196/Annals.1427.014  0.534
2008 Gagné JP, Isabelle M, Lo KS, Bourassa S, Hendzel MJ, Dawson VL, Dawson TM, Poirier GG. Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes. Nucleic Acids Research. 36: 6959-76. PMID 18981049 DOI: 10.1093/Nar/Gkn771  0.493
2008 Moore DJ, Dawson TM. Value of genetic models in understanding the cause and mechanisms of Parkinson's disease. Current Neurology and Neuroscience Reports. 8: 288-96. PMID 18590612 DOI: 10.1007/S11910-008-0045-7  0.437
2008 Sen N, Hara MR, Kornberg MD, Cascio MB, Bae BI, Shahani N, Thomas B, Dawson TM, Dawson VL, Snyder SH, Sawa A. Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nature Cell Biology. 10: 866-73. PMID 18552833 DOI: 10.1038/Ncb1747  0.8
2008 Wong ES, Tan JM, Soong WE, Hussein K, Nukina N, Dawson VL, Dawson TM, Cuervo AM, Lim KL. Autophagy-mediated clearance of aggresomes is not a universal phenomenon. Human Molecular Genetics. 17: 2570-82. PMID 18502787 DOI: 10.1093/Hmg/Ddn157  0.684
2008 Dawson TM. Non-autonomous cell death in Parkinson's disease. The Lancet. Neurology. 7: 474-5. PMID 18485311 DOI: 10.1016/S1474-4422(08)70099-1  0.439
2008 Wang L, Xie C, Greggio E, Parisiadou L, Shim H, Sun L, Chandran J, Lin X, Lai C, Yang WJ, Moore DJ, Dawson TM, Dawson VL, Chiosis G, Cookson MR, et al. The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 3384-91. PMID 18367605 DOI: 10.1523/Jneurosci.0185-08.2008  0.578
2008 Habib SL, Michel D, Masliah E, Thomas B, Ko HS, Dawson TM, Abboud H, Clark RA, Imam SZ. Role of tuberin in neuronal degeneration. Neurochemical Research. 33: 1113-6. PMID 18320306 DOI: 10.1007/S11064-007-9558-8  0.451
2008 Rudow G, O'Brien R, Savonenko AV, Resnick SM, Zonderman AB, Pletnikova O, Marsh L, Dawson TM, Crain BJ, West MJ, Troncoso JC. Morphometry of the human substantia nigra in ageing and Parkinson's disease. Acta Neuropathologica. 115: 461-70. PMID 18297291 DOI: 10.1007/S00401-008-0352-8  0.394
2008 Moore DJ, West AB, Dikeman DA, Dawson VL, Dawson TM. Parkin mediates the degradation-independent ubiquitination of Hsp70. Journal of Neurochemistry. 105: 1806-19. PMID 18248624 DOI: 10.1111/J.1471-4159.2008.05261.X  0.54
2008 Harraz MM, Dawson TM, Dawson VL. Advances in neuronal cell death 2007. Stroke; a Journal of Cerebral Circulation. 39: 286-8. PMID 18187674 DOI: 10.1161/Strokeaha.107.511857  0.748
2008 Tan JM, Wong ES, Kirkpatrick DS, Pletnikova O, Ko HS, Tay SP, Ho MW, Troncoso J, Gygi SP, Lee MK, Dawson VL, Dawson TM, Lim KL. Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases. Human Molecular Genetics. 17: 431-9. PMID 17981811 DOI: 10.1093/Hmg/Ddm320  0.688
2008 Tan JMM, Wong ESP, Dawson VL, Dawson TM, Lim KL. Lysine 63-linked polyubiquitin potentially partners with p62 to promote the clearance of protein inclusions by autophagy Autophagy. 4: 251-253. DOI: 10.4161/Auto.5444  0.673
2008 Ying M, Dawson VL, Dawson TM. Genetic Models of Familial Parkinson's Disease Parkinson's Disease. 225-236. DOI: 10.1016/B978-0-12-374028-1.00017-8  0.44
2007 Dawson TM. Unraveling the role of defective genes in Parkinson's disease. Parkinsonism & Related Disorders. 13: S248-9. PMID 18267244 DOI: 10.1016/S1353-8020(08)70010-5  0.408
2007 Biskup S, Moore DJ, Rea A, Lorenz-Deperieux B, Coombes CE, Dawson VL, Dawson TM, West AB. Dynamic and redundant regulation of LRRK2 and LRRK1 expression. Bmc Neuroscience. 8: 102. PMID 18045479 DOI: 10.1186/1471-2202-8-102  0.508
2007 Cookson MR, Dauer W, Dawson T, Fon EA, Guo M, Shen J. The roles of kinases in familial Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11865-8. PMID 17978026 DOI: 10.1523/Jneurosci.3695-07.2007  0.435
2007 Andres-Mateos E, Perier C, Zhang L, Blanchard-Fillion B, Greco TM, Thomas B, Ko HS, Sasaki M, Ischiropoulos H, Przedborski S, Dawson TM, Dawson VL. DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proceedings of the National Academy of Sciences of the United States of America. 104: 14807-12. PMID 17766438 DOI: 10.1073/Pnas.0703219104  0.549
2007 Poitras MF, Koh DW, Yu SW, Andrabi SA, Mandir AS, Poirier GG, Dawson VL, Dawson TM. Spatial and functional relationship between poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in the brain. Neuroscience. 148: 198-211. PMID 17640816 DOI: 10.1016/J.Neuroscience.2007.04.062  0.523
2007 Luo W, Wickramasinghe SR, Savitt JM, Griffin JW, Dawson TM, Ginty DD. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 54: 739-54. PMID 17553423 DOI: 10.1016/J.Neuron.2007.04.027  0.34
2007 Higashi S, Biskup S, West AB, Trinkaus D, Dawson VL, Faull RL, Waldvogel HJ, Arai H, Dawson TM, Moore DJ, Emson PC. Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain. Brain Research. 1155: 208-19. PMID 17512502 DOI: 10.1016/J.Brainres.2007.04.034  0.603
2007 Haince JF, Kozlov S, Dawson VL, Dawson TM, Hendzel MJ, Lavin MF, Poirier GG. Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents. The Journal of Biological Chemistry. 282: 16441-53. PMID 17428792 DOI: 10.1074/Jbc.M608406200  0.485
2007 Thomas B, von Coelln R, Mandir AS, Trinkaus DB, Farah MH, Leong Lim K, Calingasan NY, Flint Beal M, Dawson VL, Dawson TM. MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity. Neurobiology of Disease. 26: 312-22. PMID 17336077 DOI: 10.1016/J.Nbd.2006.12.021  0.601
2007 Wong ES, Tan JM, Wang C, Zhang Z, Tay SP, Zaiden N, Ko HS, Dawson VL, Dawson TM, Lim KL. Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations. The Journal of Biological Chemistry. 282: 12310-8. PMID 17329252 DOI: 10.1074/Jbc.M609466200  0.696
2007 Gupta A, Dawson TM. The role of stem cells in Parkinson's disease. Neurosurgery Clinics of North America. 18: 129-42, x-xi. PMID 17244560 DOI: 10.1016/J.Nec.2006.10.015  0.371
2007 West AB, Moore DJ, Choi C, Andrabi SA, Li X, Dikeman D, Biskup S, Zhang Z, Lim KL, Dawson VL, Dawson TM. Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity. Human Molecular Genetics. 16: 223-32. PMID 17200152 DOI: 10.1093/Hmg/Ddl471  0.741
2007 Higashi S, Moore DJ, Colebrooke RE, Biskup S, Dawson VL, Arai H, Dawson TM, Emson PC. Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain. Journal of Neurochemistry. 100: 368-81. PMID 17101029 DOI: 10.1111/J.1471-4159.2006.04246.X  0.608
2007 Li X, Nemoto M, Xu Z, Yu SW, Shimoji M, Andrabi SA, Haince JF, Poirier GG, Dawson TM, Dawson VL, Koehler RC. Influence of duration of focal cerebral ischemia and neuronal nitric oxide synthase on translocation of apoptosis-inducing factor to the nucleus. Neuroscience. 144: 56-65. PMID 17049179 DOI: 10.1016/J.Neuroscience.2006.08.065  0.513
2007 Jiang H, Wu YC, Nakamura M, Liang Y, Tanaka Y, Holmes S, Dawson VL, Dawson TM, Ross CA, Smith WW. Parkinson's disease genetic mutations increase cell susceptibility to stress: mutant alpha-synuclein enhances H2O2- and Sin-1-induced cell death. Neurobiology of Aging. 28: 1709-17. PMID 16978743 DOI: 10.1016/J.Neurobiolaging.2006.07.017  0.66
2007 Savitt JM, Dawson VL, Dawson TM. Parkinson Disease: Molecular Insights Molecular Neurology. 221-239. DOI: 10.1016/B978-012369509-3.50017-2  0.465
2007 Koh DW, Dawson TM, Dawson VL. Neurobiology of AIF and PARP in cerebral ischemia Handbook of Neurochemistry and Molecular Neurobiology: Acute Ischemic Injury and Repair in the Nervous System. 19-31. DOI: 10.1007/978-0-387-30383-3_2  0.356
2007 Sriram SR, Dawson VL, Dawson TM. Parkin and Neurodegeneration Protein Degradation. 4: 211-236. DOI: 10.1002/9783527619320.ch10c  0.817
2006 Biskup S, Moore DJ, Celsi F, Higashi S, West AB, Andrabi SA, Kurkinen K, Yu SW, Savitt JM, Waldvogel HJ, Faull RL, Emson PC, Torp R, Ottersen OP, Dawson TM, et al. Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Annals of Neurology. 60: 557-69. PMID 17120249 DOI: 10.1002/Ana.21019  0.522
2006 Andrabi SA, Kim NS, Yu SW, Wang H, Koh DW, Sasaki M, Klaus JA, Otsuka T, Zhang Z, Koehler RC, Hurn PD, Poirier GG, Dawson VL, Dawson TM. Poly(ADP-ribose) (PAR) polymer is a death signal. Proceedings of the National Academy of Sciences of the United States of America. 103: 18308-13. PMID 17116882 DOI: 10.1073/Pnas.0606526103  0.511
2006 Yu SW, Andrabi SA, Wang H, Kim NS, Poirier GG, Dawson TM, Dawson VL. Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Proceedings of the National Academy of Sciences of the United States of America. 103: 18314-9. PMID 17116881 DOI: 10.1073/Pnas.0606528103  0.485
2006 Dawson VL, Dawson TM. Mining for survival genes. Biochemical Society Transactions. 34: 1307-9. PMID 17073808 DOI: 10.1042/Bst0341307  0.498
2006 Dawson TM. Parkin and defective ubiquitination in Parkinson's disease. Journal of Neural Transmission. Supplementum. 209-13. PMID 17017531 DOI: 10.1007/978-3-211-45295-0_32  0.455
2006 Smith WW, Pei Z, Jiang H, Dawson VL, Dawson TM, Ross CA. Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nature Neuroscience. 9: 1231-3. PMID 16980962 DOI: 10.1038/Nn1776  0.67
2006 Dawson TM, Dawson VL. Taming the clot-buster tPA. Nature Medicine. 12: 993-4. PMID 16960567 DOI: 10.1038/Nm0906-993  0.436
2006 Savitt JM, Dawson VL, Dawson TM. Diagnosis and treatment of Parkinson disease: molecules to medicine. The Journal of Clinical Investigation. 116: 1744-54. PMID 16823471 DOI: 10.1172/Jci29178  0.567
2006 Tan JM, Dawson TM. Parkin blushed by PINK1. Neuron. 50: 527-9. PMID 16701203 DOI: 10.1016/J.Neuron.2006.05.003  0.447
2006 Ko HS, Kim SW, Sriram SR, Dawson VL, Dawson TM. Identification of far upstream element-binding protein-1 as an authentic Parkin substrate. The Journal of Biological Chemistry. 281: 16193-6. PMID 16672220 DOI: 10.1074/Jbc.C600041200  0.798
2006 von Coelln R, Thomas B, Andrabi SA, Lim KL, Savitt JM, Saffary R, Stirling W, Bruno K, Hess EJ, Lee MK, Dawson VL, Dawson TM. Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3685-96. PMID 16597723 DOI: 10.1523/Jneurosci.0414-06.2006  0.705
2006 Hara MR, Thomas B, Cascio MB, Bae BI, Hester LD, Dawson VL, Dawson TM, Sawa A, Snyder SH. Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proceedings of the National Academy of Sciences of the United States of America. 103: 3887-9. PMID 16505364 DOI: 10.1073/Pnas.0511321103  0.818
2006 Riccio A, Alvania RS, Lonze BE, Ramanan N, Kim T, Huang Y, Dawson TM, Snyder SH, Ginty DD. A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Molecular Cell. 21: 283-94. PMID 16427017 DOI: 10.1016/J.Molcel.2005.12.006  0.563
2006 Moore DJ, Dawson VL, Dawson TM. Lessons from Drosophila models of DJ-1 deficiency. Science of Aging Knowledge Environment : Sage Ke. 2006: pe2. PMID 16407572 DOI: 10.1126/Sageke.2006.2.Pe2  0.608
2006 David KK, Sasaki M, Yu SW, Dawson TM, Dawson VL. EndoG is dispensable in embryogenesis and apoptosis. Cell Death and Differentiation. 13: 1147-55. PMID 16239930 DOI: 10.1038/sj.cdd.4401787  0.448
2006 Lim KL, Dawson VL, Dawson TM. Parkin-mediated lysine 63-linked polyubiquitination: a link to protein inclusions formation in Parkinson's and other conformational diseases? Neurobiology of Aging. 27: 524-9. PMID 16213628 DOI: 10.1016/J.Neurobiolaging.2005.07.023  0.728
2006 Zhang L, Dawson VL, Dawson TM. Role of nitric oxide in Parkinson's disease. Pharmacology & Therapeutics. 109: 33-41. PMID 16005074 DOI: 10.1016/J.Pharmthera.2005.05.007  0.587
2006 Ravichandran S, Dawson TM, Dawson VL. Ubiquitination by Parkin - Implications in Parkinson's disease The Proteasome in Neurodegeneration. 213-224. DOI: 10.1007/0-387-28500-8_13  0.491
2005 Smith WW, Pei Z, Jiang H, Moore DJ, Liang Y, West AB, Dawson VL, Dawson TM, Ross CA. Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. Proceedings of the National Academy of Sciences of the United States of America. 102: 18676-81. PMID 16352719 DOI: 10.1073/Pnas.0508052102  0.692
2005 Hong SJ, Dawson VL, Dawson TM. Identification and evaluation of NO-regulated genes by differential analysis of primary cDNA library expression (DAzLE). Methods in Enzymology. 396: 359-68. PMID 16291245 DOI: 10.1016/S0076-6879(05)96030-8  0.688
2005 Chung KK, Dawson VL, Dawson TM. S-nitrosylation in Parkinson's disease and related neurodegenerative disorders. Methods in Enzymology. 396: 139-50. PMID 16291229 DOI: 10.1016/S0076-6879(05)96014-X  0.574
2005 Wang C, Ko HS, Thomas B, Tsang F, Chew KC, Tay SP, Ho MW, Lim TM, Soong TW, Pletnikova O, Troncoso J, Dawson VL, Dawson TM, Lim KL. Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function. Human Molecular Genetics. 14: 3885-97. PMID 16278233 DOI: 10.1093/Hmg/Ddi413  0.738
2005 West AB, Moore DJ, Biskup S, Bugayenko A, Smith WW, Ross CA, Dawson VL, Dawson TM. Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 102: 16842-7. PMID 16269541 DOI: 10.1073/Pnas.0507360102  0.662
2005 Smith WW, Jiang H, Pei Z, Tanaka Y, Morita H, Sawa A, Dawson VL, Dawson TM, Ross CA. Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity. Human Molecular Genetics. 14: 3801-11. PMID 16239241 DOI: 10.1093/Hmg/Ddi396  0.709
2005 Chung KK, Dawson TM, Dawson VL. Nitric oxide, S-nitrosylation and neurodegeneration. Cellular and Molecular Biology (Noisy-Le-Grand, France). 51: 247-54. PMID 16191392  0.454
2005 Ko HS, von Coelln R, Sriram SR, Kim SW, Chung KK, Pletnikova O, Troncoso J, Johnson B, Saffary R, Goh EL, Song H, Park BJ, Kim MJ, Kim S, Dawson VL, ... Dawson TM, et al. Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 7968-78. PMID 16135753 DOI: 10.1523/Jneurosci.2172-05.2005  0.828
2005 Son JH, Kawamata H, Yoo MS, Kim DJ, Lee YK, Kim S, Dawson TM, Zhang H, Sulzer D, Yang L, Beal MF, Degiorgio LA, Chun HS, Baker H, Peng C. Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons. Journal of Neurochemistry. 94: 1040-53. PMID 16092945 DOI: 10.1111/J.1471-4159.2005.03257.X  0.43
2005 Sriram SR, Li X, Ko HS, Chung KK, Wong E, Lim KL, Dawson VL, Dawson TM. Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin. Human Molecular Genetics. 14: 2571-86. PMID 16049031 DOI: 10.1093/Hmg/Ddi292  0.81
2005 Savitt JM, Jang SS, Mu W, Dawson VL, Dawson TM. Bcl-x is required for proper development of the mouse substantia nigra. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6721-8. PMID 16033881 DOI: 10.1523/Jneurosci.0760-05.2005  0.519
2005 Moore DJ, West AB, Dawson VL, Dawson TM. Molecular pathophysiology of Parkinson's disease. Annual Review of Neuroscience. 28: 57-87. PMID 16022590 DOI: 10.1146/Annurev.Neuro.28.061604.135718  0.613
2005 Smith WW, Margolis RL, Li X, Troncoso JC, Lee MK, Dawson VL, Dawson TM, Iwatsubo T, Ross CA. Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5544-52. PMID 15944382 DOI: 10.1523/Jneurosci.0482-05.2005  0.668
2005 Zhang L, Shimoji M, Thomas B, Moore DJ, Yu SW, Marupudi NI, Torp R, Torgner IA, Ottersen OP, Dawson TM, Dawson VL. Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. Human Molecular Genetics. 14: 2063-73. PMID 15944198 DOI: 10.1093/Hmg/Ddi211  0.558
2005 Pletnikova O, West N, Lee MK, Rudow GL, Skolasky RL, Dawson TM, Marsh L, Troncoso JC. Abeta deposition is associated with enhanced cortical alpha-synuclein lesions in Lewy body diseases. Neurobiology of Aging. 26: 1183-92. PMID 15917102 DOI: 10.1016/J.Neurobiolaging.2004.10.006  0.319
2005 West AB, Dawson VL, Dawson TM. To die or grow: Parkinson's disease and cancer. Trends in Neurosciences. 28: 348-52. PMID 15913799 DOI: 10.1016/J.Tins.2005.05.002  0.558
2005 Koh DW, Dawson TM, Dawson VL. Mediation of cell death by poly(ADP-ribose) polymerase-1. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 52: 5-14. PMID 15911329 DOI: 10.1016/J.Phrs.2005.02.011  0.543
2005 Berg D, Niwar M, Maass S, Zimprich A, Möller JC, Wuellner U, Schmitz-Hübsch T, Klein C, Tan EK, Schöls L, Marsh L, Dawson TM, Janetzky B, Müller T, Woitalla D, et al. Alpha-synuclein and Parkinson's disease: implications from the screening of more than 1,900 patients. Movement Disorders : Official Journal of the Movement Disorder Society. 20: 1191-4. PMID 15895422 DOI: 10.1002/Mds.20504  0.342
2005 Koh DW, Dawson TM, Dawson VL. Poly(ADP-ribosyl)ation regulation of life and death in the nervous system. Cellular and Molecular Life Sciences : Cmls. 62: 760-8. PMID 15868401 DOI: 10.1007/S00018-004-4508-Y  0.574
2005 Pol O, Sasaki M, Jiménez N, Dawson VL, Dawson TM, Puig MM. The involvement of nitric oxide in the enhanced expression of mu-opioid receptors during intestinal inflammation in mice. British Journal of Pharmacology. 145: 758-66. PMID 15852037 DOI: 10.1038/Sj.Bjp.0706227  0.471
2005 Wang C, Tan JM, Ho MW, Zaiden N, Wong SH, Chew CL, Eng PW, Lim TM, Dawson TM, Lim KL. Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease-linked point mutations. Journal of Neurochemistry. 93: 422-31. PMID 15816865 DOI: 10.1111/J.1471-4159.2005.03023.X  0.65
2005 Shimoji M, Zhang L, Mandir AS, Dawson VL, Dawson TM. Absence of inclusion body formation in the MPTP mouse model of Parkinson's disease. Brain Research. Molecular Brain Research. 134: 103-8. PMID 15790534 DOI: 10.1016/J.Molbrainres.2005.01.012  0.566
2005 Lim KL, Chew KC, Tan JM, Wang C, Chung KK, Zhang Y, Tanaka Y, Smith W, Engelender S, Ross CA, Dawson VL, Dawson TM. Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2002-9. PMID 15728840 DOI: 10.1523/Jneurosci.4474-04.2005  0.75
2005 Koh DW, Dawson VL, Dawson TM. The road to survival goes through PARG. Cell Cycle (Georgetown, Tex.). 4: 397-9. PMID 15725727 DOI: 10.4161/Cc.4.3.1559  0.509
2005 Moore DJ, Zhang L, Troncoso J, Lee MK, Hattori N, Mizuno Y, Dawson TM, Dawson VL. Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress. Human Molecular Genetics. 14: 71-84. PMID 15525661 DOI: 10.1093/Hmg/Ddi007  0.591
2005 Kim SW, Ko HS, Dawson VL, Dawson TM. Recent advances in our understanding of Parkinson's disease Drug Discovery Today: Disease Mechanisms. 2: 427-433. DOI: 10.1016/J.Ddmec.2005.11.015  0.588
2004 Chung KK, Dawson TM. Parkin and Hsp70 sacked by BAG5. Neuron. 44: 899-901. PMID 15603730 DOI: 10.1016/J.Neuron.2004.12.007  0.45
2004 Koh DW, Lawler AM, Poitras MF, Sasaki M, Wattler S, Nehls MC, Stöger T, Poirier GG, Dawson VL, Dawson TM. Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality. Proceedings of the National Academy of Sciences of the United States of America. 101: 17699-704. PMID 15591342 DOI: 10.1073/Pnas.0406182101  0.487
2004 Wang H, Yu SW, Koh DW, Lew J, Coombs C, Bowers W, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10963-73. PMID 15574746 DOI: 10.1523/Jneurosci.3461-04.2004  0.529
2004 von Coelln R, Dawson VL, Dawson TM. Parkin-associated Parkinson's disease. Cell and Tissue Research. 318: 175-84. PMID 15503153 DOI: 10.1007/S00441-004-0924-4  0.584
2004 Dawson VL, Dawson TM. Deadly conversations: nuclear-mitochondrial cross-talk. Journal of Bioenergetics and Biomembranes. 36: 287-94. PMID 15377859 DOI: 10.1023/B:Jobb.0000041755.22613.8D  0.58
2004 Hagberg H, Wilson MA, Matsushita H, Zhu C, Lange M, Gustavsson M, Poitras MF, Dawson TM, Dawson VL, Northington F, Johnston MV. PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury. Journal of Neurochemistry. 90: 1068-75. PMID 15312162 DOI: 10.1111/J.1471-4159.2004.02547.X  0.499
2004 Marsh L, Williams JR, Rocco M, Grill S, Munro C, Dawson TM. Psychiatric comorbidities in patients with Parkinson disease and psychosis. Neurology. 63: 293-300. PMID 15277623 DOI: 10.1212/01.Wnl.0000129843.15756.A3  0.307
2004 Von Coelln R, Thomas B, Savitt JM, Lim KL, Sasaki M, Hess EJ, Dawson VL, Dawson TM. Loss of locus coeruleus neurons and reduced startle in parkin null mice. Proceedings of the National Academy of Sciences of the United States of America. 101: 10744-9. PMID 15249681 DOI: 10.1073/Pnas.0401297101  0.751
2004 Petrucelli L, Dawson TM. Mechanism of neurodegenerative disease: role of the ubiquitin proteasome system. Annals of Medicine. 36: 315-20. PMID 15224658 DOI: 10.1080/07853890410031948  0.446
2004 Hong SJ, Dawson TM, Dawson VL. Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling. Trends in Pharmacological Sciences. 25: 259-64. PMID 15120492 DOI: 10.1016/J.Tips.2004.03.005  0.7
2004 Samdani AF, Kuchner EB, Rhines L, Adamson DC, Lawson C, Tyler B, Brem H, Dawson VL, Dawson TM. Astroglia induce cytotoxic effects on brain tumors via a nitric oxide-dependent pathway both in vitro and in vivo. Neurosurgery. 54: 1231-7; discussion 1. PMID 15113479 DOI: 10.1227/01.Neu.0000119576.76193.B8  0.49
2004 Chung KK, Thomas B, Li X, Pletnikova O, Troncoso JC, Marsh L, Dawson VL, Dawson TM. S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science (New York, N.Y.). 304: 1328-31. PMID 15105460 DOI: 10.1126/Science.1093891  0.677
2004 Liang D, Dawson TM, Dawson VL. What have genetically engineered mice taught us about ischemic injury? Current Molecular Medicine. 4: 207-25. PMID 15032714 DOI: 10.2174/1566524043479194  0.506
2004 Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M, McGowan E, Lewis J, Prihar G, Kim J, Dillmann WH, Browne SE, Hall A, Voellmy R, ... ... Dawson TM, et al. CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Human Molecular Genetics. 13: 703-14. PMID 14962978 DOI: 10.1093/Hmg/Ddh083  0.327
2004 Hong SJ, Li H, Becker KG, Dawson VL, Dawson TM. Identification and analysis of plasticity-induced late-response genes. Proceedings of the National Academy of Sciences of the United States of America. 101: 2145-50. PMID 14766980 DOI: 10.1073/Pnas.0305170101  0.697
2004 Li H, Gu X, Dawson VL, Dawson TM. Identification of calcium- and nitric oxide-regulated genes by differential analysis of library expression (DAzLE). Proceedings of the National Academy of Sciences of the United States of America. 101: 647-52. PMID 14701905 DOI: 10.1073/Pnas.0305145101  0.528
2004 von Coelln R, Thomas B, Lim K, Hess E, Lee M, Dawson V, Dawson T. Alpha-Synuclein-induzierte Proteinaggregation und Neurodegeneration in vivo sind Parkin-unabhängig Aktuelle Neurologie. 31. DOI: 10.1055/S-2004-833018  0.63
2004 Dawson TM. S4-03-02 Role of parkin in defective ubiquitination and alpha-synuclein turnover in parkinson's disease Neurobiology of Aging. 25: S70. DOI: 10.1016/S0197-4580(04)80238-0  0.338
2003 Moore DJ, Zhang L, Dawson TM, Dawson VL. A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization. Journal of Neurochemistry. 87: 1558-67. PMID 14713311 DOI: 10.1111/J.1471-4159.2003.02265.X  0.537
2003 Yu SW, Wang H, Dawson TM, Dawson VL. Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity. Neurobiology of Disease. 14: 303-17. PMID 14678748 DOI: 10.1016/J.Nbd.2003.08.008  0.515
2003 Eriksen JL, Dawson TM, Dickson DW, Petrucelli L. Caught in the act: alpha-synuclein is the culprit in Parkinson's disease. Neuron. 40: 453-6. PMID 14642269 DOI: 10.1016/S0896-6273(03)00684-6  0.368
2003 Dawson TM, Dawson VL. Molecular pathways of neurodegeneration in Parkinson's disease. Science (New York, N.Y.). 302: 819-22. PMID 14593166 DOI: 10.1126/Science.1087753  0.605
2003 Chung KK, Dawson VL, Dawson TM. New insights into Parkinson's disease. Journal of Neurology. 250: III15-24. PMID 14579120 DOI: 10.1007/S00415-003-1304-9  0.582
2003 Choi P, Snyder H, Petrucelli L, Theisler C, Chong M, Zhang Y, Lim K, Chung KK, Kehoe K, D'Adamio L, Lee JM, Cochran E, Bowser R, Dawson TM, Wolozin B. SEPT5_v2 is a parkin-binding protein. Brain Research. Molecular Brain Research. 117: 179-89. PMID 14559152 DOI: 10.1016/S0169-328X(03)00318-8  0.631
2003 Moore DJ, Dawson VL, Dawson TM. Role for the ubiquitin-proteasome system in Parkinson's disease and other neurodegenerative brain amyloidoses. Neuromolecular Medicine. 4: 95-108. PMID 14528055 DOI: 10.1385/Nmm:4:1-2:95  0.605
2003 Pawlyk AC, Giasson BI, Sampathu DM, Perez FA, Lim KL, Dawson VL, Dawson TM, Palmiter RD, Trojanowski JQ, Lee VM. Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age. The Journal of Biological Chemistry. 278: 48120-8. PMID 12972409 DOI: 10.1074/Jbc.M306889200  0.68
2003 Moore DJ, Dawson VL, Dawson TM. Genetics of Parkinson's disease: what do mutations in DJ-1 tell us? Annals of Neurology. 54: 281-2. PMID 12953259 DOI: 10.1002/Ana.10740  0.521
2003 Wang H, Shimoji M, Yu SW, Dawson TM, Dawson VL. Apoptosis inducing factor and PARP-mediated injury in the MPTP mouse model of Parkinson's disease. Annals of the New York Academy of Sciences. 991: 132-9. PMID 12846982 DOI: 10.1111/J.1749-6632.2003.Tb07471.X  0.627
2003 Lim KL, Dawson VL, Dawson TM. The cast of molecular characters in Parkinson's disease: felons, conspirators, and suspects. Annals of the New York Academy of Sciences. 991: 80-92. PMID 12846976 DOI: 10.1111/J.1749-6632.2003.Tb07465.X  0.733
2003 Ravina BM, Fagan SC, Hart RG, Hovinga CA, Murphy DD, Dawson TM, Marler JR. Neuroprotective agents for clinical trials in Parkinson's disease: a systematic assessment. Neurology. 60: 1234-40. PMID 12707423 DOI: 10.1212/01.Wnl.0000058760.13152.1A  0.375
2003 Fannjiang Y, Kim CH, Huganir RL, Zou S, Lindsten T, Thompson CB, Mito T, Traystman RJ, Larsen T, Griffin DE, Mandir AS, Dawson TM, Dike S, Sappington AL, Kerr DA, et al. BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development. Developmental Cell. 4: 575-85. PMID 12689595 DOI: 10.1016/S1534-5807(03)00091-1  0.399
2003 Chung JW, Hong SJ, Kim KJ, Goti D, Stins MF, Shin S, Dawson VL, Dawson TM, Kim KS. 37-kDa laminin receptor precursor modulates cytotoxic necrotizing factor 1-mediated RhoA activation and bacterial uptake. The Journal of Biological Chemistry. 278: 16857-62. PMID 12615923 DOI: 10.1074/Jbc.M301028200  0.693
2003 Dawson TM, Dawson VL. Rare genetic mutations shed light on the pathogenesis of Parkinson disease. The Journal of Clinical Investigation. 111: 145-51. PMID 12531866 DOI: 10.1172/Jci17575  0.589
2003 Nucifora FC, Ellerby LM, Wellington CL, Wood JD, Herring WJ, Sawa A, Hayden MR, Dawson VL, Dawson TM, Ross CA. Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity. The Journal of Biological Chemistry. 278: 13047-55. PMID 12464607 DOI: 10.1074/Jbc.M211224200  0.676
2002 Wei X, Sasaki M, Huang H, Dawson VL, Dawson TM. The orphan nuclear receptor, steroidogenic factor 1, regulates neuronal nitric oxide synthase gene expression in pituitary gonadotropes. Molecular Endocrinology (Baltimore, Md.). 16: 2828-39. PMID 12456803 DOI: 10.1210/Me.2001-0273  0.621
2002 Dawson TM, Dawson VL. Neuroprotective and neurorestorative strategies for Parkinson's disease. Nature Neuroscience. 5: 1058-61. PMID 12403986 DOI: 10.1038/Nn941  0.551
2002 Mandir AS, Simbulan-Rosenthal CM, Poitras MF, Lumpkin JR, Dawson VL, Smulson ME, Dawson TM. A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism. Journal of Neurochemistry. 83: 186-92. PMID 12358742 DOI: 10.1046/J.1471-4159.2002.01144.X  0.605
2002 Lim KL, Dawson VL, Dawson TM. The genetics of Parkinson's disease. Current Neurology and Neuroscience Reports. 2: 439-46. PMID 12169225 DOI: 10.1007/S11910-002-0071-9  0.711
2002 Dawson T, Mandir A, Lee M. Animal models of PD: pieces of the same puzzle? Neuron. 35: 219-22. PMID 12160740 DOI: 10.1016/S0896-6273(02)00780-8  0.365
2002 Cregan SP, Fortin A, MacLaurin JG, Callaghan SM, Cecconi F, Yu SW, Dawson TM, Dawson VL, Park DS, Kroemer G, Slack RS. Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. The Journal of Cell Biology. 158: 507-17. PMID 12147675 DOI: 10.1083/Jcb.200202130  0.549
2002 Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science (New York, N.Y.). 297: 259-63. PMID 12114629 DOI: 10.1126/Science.1072221  0.503
2002 Lee MK, Stirling W, Xu Y, Xu X, Qui D, Mandir AS, Dawson TM, Copeland NG, Jenkins NA, Price DL. Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 8968-73. PMID 12084935 DOI: 10.1073/Pnas.132197599  0.353
2002 Dawson TM, Ginty DD. CREB family transcription factors inhibit neuronal suicide. Nature Medicine. 8: 450-1. PMID 11984583 DOI: 10.1038/Nm0502-450  0.372
2002 Goto S, Xue R, Sugo N, Sawada M, Blizzard KK, Poitras MF, Johns DC, Dawson TM, Dawson VL, Crain BJ, Traystman RJ, Mori S, Hurn PD. Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery. Stroke; a Journal of Cerebral Circulation. 33: 1101-6. PMID 11935067 DOI: 10.1161/01.Str.0000014203.65693.1E  0.483
2002 Dawson TM. Preconditioning-mediated neuroprotection through erythropoietin? Lancet. 359: 96-7. PMID 11809248 DOI: 10.1016/S0140-6736(02)07335-X  0.321
2001 Gonzalez-Zulueta M, Dawson VL, Dawson TM. Histochemical analysis of nitric oxide synthase by NADPH diaphorase staining. Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. Unit 10.6. PMID 23045028 DOI: 10.1002/0471140856.Tx1006S01  0.47
2001 Dillman JF, Dawson VL, Dawson TM. Overview of the pathway and functions of nitric oxide. Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. Unit 10.1. PMID 23045023 DOI: 10.1002/0471140856.Tx1001S00  0.475
2001 Przedborski S, Dawson TM. The role of nitric oxide in Parkinson's disease. Methods in Molecular Medicine. 62: 113-36. PMID 21318772 DOI: 10.1385/1-59259-142-6:113  0.317
2001 Chung KK, Dawson VL, Dawson TM. The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders. Trends in Neurosciences. 24: S7-14. PMID 11881748 DOI: 10.1016/S0166-2236(00)01998-6  0.586
2001 Chung KK, Zhang Y, Lim KL, Tanaka Y, Huang H, Gao J, Ross CA, Dawson VL, Dawson TM. Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nature Medicine. 7: 1144-50. PMID 11590439 DOI: 10.1038/Nm1001-1144  0.745
2001 Wildemann B, Haas J, Stingele K, Storch-HagenIocher B, McArthur JC, Dawson TM, Dawson VL. Identification by mRNA differential display of two up-regulated genes as candidate mediators of AIDS dementia. Molecular Medicine (Cambridge, Mass.). 7: 193-9. PMID 11471556 DOI: 10.1007/Bf03401953  0.5
2001 Guo X, Dillman JF, Dawson VL, Dawson TM. Neuroimmunophilins: novel neuroprotective and neuroregenerative targets. Annals of Neurology. 50: 6-16. PMID 11456311 DOI: 10.1002/Ana.1030  0.534
2001 Guo X, Dawson VL, Dawson TM. Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons. The European Journal of Neuroscience. 13: 1683-93. PMID 11359520 DOI: 10.1046/J.0953-816X.2001.01542.X  0.551
2001 Tanaka Y, Engelender S, Igarashi S, Rao RK, Wanner T, Tanzi RE, Sawa A, L Dawson V, Dawson TM, Ross CA. Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Human Molecular Genetics. 10: 919-26. PMID 11309365 DOI: 10.1093/Hmg/10.9.919  0.663
2001 Nandagopal K, Dawson TM, Dawson VL. Critical role for nitric oxide signaling in cardiac and neuronal ischemic preconditioning and tolerance. The Journal of Pharmacology and Experimental Therapeutics. 297: 474-8. PMID 11303032  0.428
2001 Nucifora FC, Sasaki M, Peters MF, Huang H, Cooper JK, Yamada M, Takahashi H, Tsuji S, Troncoso J, Dawson VL, Dawson TM, Ross CA. Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science (New York, N.Y.). 291: 2423-8. PMID 11264541 DOI: 10.1126/Science.1056784  0.654
2001 Mandir AS, Dawson VL, Dawson TM. Gene therapy to the rescue in Parkinson's disease. Trends in Pharmacological Sciences. 22: 103-5; discussion 10. PMID 11239561 DOI: 10.1016/S0165-6147(00)01638-2  0.581
2001 Aghdasi B, Ye K, Resnick A, Huang A, Ha HC, Guo X, Dawson TM, Dawson VL, Snyder SH. FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle. Proceedings of the National Academy of Sciences of the United States of America. 98: 2425-30. PMID 11226255 DOI: 10.1073/Pnas.041614198  0.758
2001 Chiavegatto S, Dawson VL, Mamounas LA, Koliatsos VE, Dawson TM, Nelson RJ. Brain serotonin dysfunction accounts for aggression in male mice lacking neuronal nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. 98: 1277-81. PMID 11158630 DOI: 10.1073/Pnas.98.3.1277  0.762
2001 Zhang Y, Dawson VL, Dawson TM. Parkin: Clinical aspects and neurobiology Clinical Neuroscience Research. 1: 467-482. DOI: 10.1016/S1566-2772(01)00025-1  0.568
2001 Chung KK, Dawson VL, Dawson TM. The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders Trends in Neurosciences. 24: 7-14. DOI: 10.1016/S0166-2236(01)00003-0  0.482
2000 Dawson VL, Dawson TM. Neuronal ischaemic preconditioning. Trends in Pharmacological Sciences. 21: 423-4. PMID 11126374 DOI: 10.1016/S0165-6147(00)01560-1  0.528
2000 Zhang Y, Gao J, Chung KK, Huang H, Dawson VL, Dawson TM. Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Proceedings of the National Academy of Sciences of the United States of America. 97: 13354-9. PMID 11078524 DOI: 10.1073/Pnas.240347797  0.537
2000 Sampei K, Mandir AS, Asano Y, Wong PC, Traystman RJ, Dawson VL, Dawson TM, Hurn PD. Stroke outcome in double-mutant antioxidant transgenic mice. Stroke; a Journal of Cerebral Circulation. 31: 2685-91. PMID 11062295 DOI: 10.1161/01.Str.31.11.2685  0.503
2000 Mandir AS, Poitras MF, Berliner AR, Herring WJ, Guastella DB, Feldman A, Poirier GG, Wang ZQ, Dawson TM, Dawson VL. NMDA but not non-NMDA excitotoxicity is mediated by Poly(ADP-ribose) polymerase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 8005-11. PMID 11050121 DOI: 10.1523/Jneurosci.20-21-08005.2000  0.51
2000 Zhang Y, Dawson VL, Dawson TM. Oxidative stress and genetics in the pathogenesis of Parkinson's disease. Neurobiology of Disease. 7: 240-50. PMID 10964596 DOI: 10.1006/Nbdi.2000.0319  0.586
2000 Sasaki M, Gonzalez-Zulueta M, Huang H, Herring WJ, Ahn S, Ginty DD, Dawson VL, Dawson TM. Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism. Proceedings of the National Academy of Sciences of the United States of America. 97: 8617-22. PMID 10900019 DOI: 10.1073/Pnas.97.15.8617  0.52
2000 Marsh L, Dawson TM. Treatment of early Parkinson's disease. Bmj (Clinical Research Ed.). 321: 1-2. PMID 10875807 DOI: 10.1136/Bmj.321.7252.1  0.343
2000 Dawson TM. New animal models for Parkinson's disease. Cell. 101: 115-8. PMID 10786830 DOI: 10.1016/S0092-8674(00)80629-7  0.441
2000 Przedborski S, Vila M, Jackson-Lewis V, Dawson TM. Reply: a new look at the pathogenesis of Parkinson's disease Trends in Pharmacological Sciences. 21: 165. PMID 10785645 DOI: 10.1016/S0165-6147(00)01470-X  0.452
2000 Gonzalez-Zulueta M, Feldman AB, Klesse LJ, Kalb RG, Dillman JF, Parada LF, Dawson TM, Dawson VL. Requirement for nitric oxide activation of p21(ras)/extracellular regulated kinase in neuronal ischemic preconditioning. Proceedings of the National Academy of Sciences of the United States of America. 97: 436-41. PMID 10618436 DOI: 10.1073/Pnas.97.1.436  0.501
2000 Dawson TM. Parkinson's disease: clinical manifestations and treatment International Review of Psychiatry. 12: 263-269. DOI: 10.1080/09540260020002488  0.369
2000 Dawson TM. Molecular mechanisms of neuronal cell death in animal models of Parkinson's disease Neurobiology of Aging. 21: 135. DOI: 10.1016/S0197-4580(00)82408-2  0.415
1999 Yun HY, Dawson VL, Dawson TM. Glutamate-stimulated calcium activation of Ras/Erk pathway mediated by nitric oxide. Diabetes Research and Clinical Practice. 45: 113-5. PMID 10588362 DOI: 10.1016/S0168-8227(99)00039-X  0.494
1999 Liberatore GT, Jackson-Lewis V, Vukosavic S, Mandir AS, Vila M, McAuliffe WG, Dawson VL, Dawson TM, Przedborski S. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nature Medicine. 5: 1403-9. PMID 10581083 DOI: 10.1038/70978  0.597
1999 Peters MF, Nucifora FC, Kushi J, Seaman HC, Cooper JK, Herring WJ, Dawson VL, Dawson TM, Ross CA. Nuclear targeting of mutant Huntingtin increases toxicity. Molecular and Cellular Neurosciences. 14: 121-8. PMID 10479410 DOI: 10.1006/Mcne.1999.0773  0.607
1999 Toung TJ, Bhardwaj A, Dawson VL, Dawson TM, Traystman RJ, Hurn PD. Neuroprotective FK506 does not alter in vivo nitric oxide production during ischemia and early reperfusion in rats. Stroke; a Journal of Cerebral Circulation. 30: 1279-85. PMID 10356112 DOI: 10.1161/01.Str.30.6.1279  0.472
1999 Facchinetti F, Sasaki M, Cutting FB, Zhai P, MacDonald JE, Reif D, Beal MF, Huang PL, Dawson TM, Gurney ME, Dawson VL. Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis. Neuroscience. 90: 1483-92. PMID 10338314 DOI: 10.1016/S0306-4522(98)00492-8  0.539
1999 Engelender S, Kaminsky Z, Guo X, Sharp AH, Amaravi RK, Kleiderlein JJ, Margolis RL, Troncoso JC, Lanahan AA, Worley PF, Dawson VL, Dawson TM, Ross CA. Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions. Nature Genetics. 22: 110-4. PMID 10319874 DOI: 10.1038/8820  0.72
1999 Mandir AS, Przedborski S, Jackson-Lewis V, Wang ZQ, Simbulan-Rosenthal CM, Smulson ME, Hoffman BE, Guastella DB, Dawson VL, Dawson TM. Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. Proceedings of the National Academy of Sciences of the United States of America. 96: 5774-9. PMID 10318960 DOI: 10.1073/Pnas.96.10.5774  0.616
1999 Adamson DC, McArthur JC, Dawson TM, Dawson VL. Rate and severity of HIV-associated dementia (HAD): correlations with Gp41 and iNOS. Molecular Medicine (Cambridge, Mass.). 5: 98-109. PMID 10203575 DOI: 10.1007/Bf03402144  0.465
1999 Kriegsfeld LJ, Eliasson MJ, Demas GE, Blackshaw S, Dawson TM, Nelson RJ, Snyder SH. Nocturnal motor coordination deficits in neuronal nitric oxide synthase knock-out mice. Neuroscience. 89: 311-5. PMID 10077313 DOI: 10.1016/S0306-4522(98)00614-9  0.807
1999 Kriegsfeld LJ, Demas GE, Lee SE, Dawson TM, Dawson VL, Nelson RJ. Circadian locomotor analysis of male mice lacking the gene for neuronal nitric oxide synthase (nNOS-/-) Journal of Biological Rhythms. 14: 20-7. PMID 10036989 DOI: 10.1177/074873099129000407  0.598
1999 Xu KY, Huso DL, Dawson TM, Bredt DS, Becker LC. Nitric oxide synthase in cardiac sarcoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America. 96: 657-62. PMID 9892689 DOI: 10.1073/Pnas.96.2.657  0.517
1999 Adamson DC, Kopnisky KL, Dawson TM, Dawson VL. Mechanisms and structural determinants of HIV-1 coat protein, gp41-induced neurotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 64-71. PMID 9870939 DOI: 10.1523/Jneurosci.19-01-00064.1999  0.52
1998 Dawson VL, Dawson TM. Nitric oxide in neurodegeneration. Progress in Brain Research. 118: 215-29. PMID 9932444 DOI: 10.1016/S0079-6123(08)63210-0  0.556
1998 Dawson TM, Sasaki M, Gonzalez-Zulueta M, Dawson VL. Regulation of neuronal nitric oxide synthase and identification of novel nitric oxide signaling pathways. Progress in Brain Research. 118: 3-11. PMID 9932430 DOI: 10.1016/S0079-6123(08)63196-9  0.553
1998 Facchinetti F, Dawson VL, Dawson TM. Free radicals as mediators of neuronal injury. Cellular and Molecular Neurobiology. 18: 667-82. PMID 9876873 DOI: 10.1023/A:1020685903186  0.527
1998 Klein SL, Carnovale D, Burnett AL, Wallach EE, Zacur HA, Crone JK, Dawson VL, Nelson RJ, Dawson TM. Impaired ovulation in mice with targeted deletion of the neuronal isoform of nitric oxide synthase. Molecular Medicine (Cambridge, Mass.). 4: 658-64. PMID 9848082 DOI: 10.1007/Bf03401926  0.591
1998 Jumrussirikul P, Dinerman J, Dawson TM, Dawson VL, Ekelund U, Georgakopoulos D, Schramm LP, Calkins H, Snyder SH, Hare JM, Berger RD. Interaction between neuronal nitric oxide synthase and inhibitory G protein activity in heart rate regulation in conscious mice. The Journal of Clinical Investigation. 102: 1279-85. PMID 9769319 DOI: 10.1172/Jci2843  0.63
1998 Walensky LD, Dawson TM, Steiner JP, Sabatini DM, Suarez JD, Klinefelter GR, Snyder SH. The 12 kD FK 506 binding protein FKBP12 is released in the male reproductive tract and stimulates sperm motility. Molecular Medicine (Cambridge, Mass.). 4: 502-14. PMID 9742506  0.62
1998 Yun HY, Gonzalez-Zulueta M, Dawson VL, Dawson TM. Nitric oxide mediates N-methyl-D-aspartate receptor-induced activation of p21ras. Proceedings of the National Academy of Sciences of the United States of America. 95: 5773-8. PMID 9576960 DOI: 10.1073/Pnas.95.10.5773  0.505
1998 Crosbie RH, Straub V, Yun HY, Lee JC, Rafael JA, Chamberlain JS, Dawson VL, Dawson TM, Campbell KP. mdx muscle pathology is independent of nNOS perturbation. Human Molecular Genetics. 7: 823-9. PMID 9536086 DOI: 10.1093/Hmg/7.5.823  0.478
1998 Cooper JK, Schilling G, Peters MF, Herring WJ, Sharp AH, Kaminsky Z, Masone J, Khan FA, Delanoy M, Borchelt DR, Dawson VL, Dawson TM, Ross CA. Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture. Human Molecular Genetics. 7: 783-90. PMID 9536081 DOI: 10.1093/Hmg/7.5.783  0.615
1998 Gonzalez-Zulueta M, Ensz LM, Mukhina G, Lebovitz RM, Zwacka RM, Engelhardt JF, Oberley LW, Dawson VL, Dawson TM. Manganese superoxide dismutase protects nNOS neurons from NMDA and nitric oxide-mediated neurotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 2040-55. PMID 9482791 DOI: 10.1523/Jneurosci.18-06-02040.1998  0.538
1998 Weiss SW, Albers DS, Iadarola MJ, Dawson TM, Dawson VL, Standaert DG. NMDAR1 glutamate receptor subunit isoforms in neostriatal, neocortical, and hippocampal nitric oxide synthase neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 1725-34. PMID 9464997 DOI: 10.1523/Jneurosci.18-05-01725.1998  0.545
1998 Gonzalez-Zulueta M, Ensz LM, Mukhina G, Lebovitz RM, Zwacka RM, Engelhardt JF, Oberley LW, Dawson VL, Dawson TM. Manganese Superoxide Dismutase Protects nNOS Neurons from NMDA and Nitric Oxide-Mediated Neurotoxicity The Journal of Neuroscience. 18: 2040-2055. DOI: 10.1523/JNEUROSCI.18-06-02040.1998  0.463
1998 Dawson TM, Gonzalez-ZuluetaS M, Kusel J, Dawson VL. Nitric Oxide: Diverse Actions in the Central and Peripheral Nervous Systems The Neuroscientist. 4: 96-112. DOI: 10.1177/107385849800400206  0.5
1998 Warner DS, Eliasson MJ, Sampei K, Mandir AS, Hum PD, Traystman RJ, Bao J, Pieper A, Wang Z, Dawson TM, Snyder SH, Dawson VL. Journal Club Journal of Neurosurgical Anesthesiology. 10: 124. DOI: 10.1097/00008506-199804000-00012  0.645
1998 Walensky LD, Dawson TM, Steiner JP, Sabatini DM, Suarez JD, Klinefelter GR, Snyder SH. The 12 kD FK506 Binding Protein FKBP12 Is Released in the Male Reproductive Tract and Stimulates Sperm Motility Molecular Medicine. 4: 502-514. DOI: 10.1007/Bf03401755  0.709
1997 Kriegsfeld LJ, Dawson TM, Dawson VL, Nelson RJ, Snyder SH. Aggressive behavior in male mice lacking the gene for neuronal nitric oxide synthase requires testosterone. Brain Research. 769: 66-70. PMID 9374274 DOI: 10.1016/S0006-8993(97)00688-4  0.664
1997 Nelson RJ, Kriegsfeld LJ, Dawson VL, Dawson TM. Effects of nitric oxide on neuroendocrine function and behavior. Frontiers in Neuroendocrinology. 18: 463-91. PMID 9344634 DOI: 10.1006/Frne.1997.0156  0.571
1997 Eliasson MJ, Sampei K, Mandir AS, Hurn PD, Traystman RJ, Bao J, Pieper A, Wang ZQ, Dawson TM, Snyder SH, Dawson VL. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nature Medicine. 3: 1089-95. PMID 9334719 DOI: 10.1038/Nm1097-1089  0.804
1997 Demas GE, Eliasson MJ, Dawson TM, Dawson VL, Kriegsfeld LJ, Nelson RJ, Snyder SH. Inhibition of neuronal nitric oxide synthase increases aggressive behavior in mice. Molecular Medicine (Cambridge, Mass.). 3: 610-6. PMID 9323712 DOI: 10.1007/Bf03401818  0.794
1997 Yun HY, Dawson VL, Dawson TM. Nitric oxide in health and disease of the nervous system. Molecular Psychiatry. 2: 300-10. PMID 9246670  0.489
1997 Samdani AF, Dawson TM, Dawson VL. Nitric oxide synthase in models of focal ischemia. Stroke; a Journal of Cerebral Circulation. 28: 1283-8. PMID 9183363 DOI: 10.1161/01.Str.28.6.1283  0.526
1997 Samdani AF, Newcamp C, Resink A, Facchinetti F, Hoffman BE, Dawson VL, Dawson TM. Differential susceptibility to neurotoxicity mediated by neurotrophins and neuronal nitric oxide synthase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 4633-41. PMID 9169524 DOI: 10.1523/Jneurosci.17-12-04633.1997  0.544
1997 Burnett AL, Calvin DC, Chamness SL, Liu JX, Nelson RJ, Klein SL, Dawson VL, Dawson TM, Snyder SH. Urinary bladder-urethral sphincter dysfunction in mice with targeted disruption of neuronal nitric oxide synthase models idiopathic voiding disorders in humans. Nature Medicine. 3: 571-4. PMID 9142130 DOI: 10.1038/Nm0597-571  0.68
1997 Togashi H, Sasaki M, Frohman E, Taira E, Ratan RR, Dawson TM, Dawson VL. Neuronal (type I) nitric oxide synthase regulates nuclear factor kappaB activity and immunologic (type II) nitric oxide synthase expression. Proceedings of the National Academy of Sciences of the United States of America. 94: 2676-80. PMID 9122255 DOI: 10.1073/Pnas.94.6.2676  0.51
1997 Aoki C, Rhee J, Lubin M, Dawson TM. NMDA-R1 subunit of the cerebral cortex co-localizes with neuronal nitric oxide synthase at pre- and postsynaptic sites and in spines. Brain Research. 750: 25-40. PMID 9098526 DOI: 10.1016/S0006-8993(96)01147-X  0.309
1997 Steiner JP, Connolly MA, Valentine HL, Hamilton GS, Dawson TM, Hester L, Snyder SH. Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A. Nature Medicine. 3: 421-8. PMID 9095176 DOI: 10.1038/Nm0497-421  0.523
1996 Dawson VL, Dawson TM. Free radicals and neuronal cell death. Cell Death and Differentiation. 3: 71-8. PMID 17180057  0.423
1996 Karson CN, Griffin WS, Mrak RE, Husain M, Dawson TM, Snyder SH, Moore NC, Sturner WQ. Nitric oxide synthase (NOS) in schizophrenia: increases in cerebellar vermis. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 27: 275-84. PMID 9147413 DOI: 10.1007/Bf02815109  0.503
1996 Yun HY, Dawson VL, Dawson TM. Neurobiology of nitric oxide. Critical Reviews in Neurobiology. 10: 291-316. PMID 8978984 DOI: 10.1615/Critrevneurobiol.V10.I3-4.20  0.502
1996 Adamson DC, Wildemann B, Sasaki M, Glass JD, McArthur JC, Christov VI, Dawson TM, Dawson VL. Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41. Science (New York, N.Y.). 274: 1917-21. PMID 8943206 DOI: 10.1126/Science.274.5294.1917  0.486
1996 Ruthazer ES, Gillespie DC, Dawson TM, Snyder SH, Stryker MP. Inhibition of nitric oxide synthase does not prevent ocular dominance plasticity in kitten visual cortex. The Journal of Physiology. 494: 519-27. PMID 8842009 DOI: 10.1113/Jphysiol.1996.Sp021510  0.419
1996 Dawson VL, Dawson TM. Nitric oxide actions in neurochemistry. Neurochemistry International. 29: 97-110. PMID 8837037 DOI: 10.1016/0197-0186(95)00149-2  0.534
1996 Adamson DC, Dawson TM, Zink MC, Clements JE, Dawson VL. Neurovirulent simian immunodeficiency virus infection induces neuronal, endothelial, and glial apoptosis. Molecular Medicine (Cambridge, Mass.). 2: 417-28. PMID 8827712 DOI: 10.1007/Bf03401901  0.52
1996 Dawson VL, Dawson TM. Nitric oxide neurotoxicity. Journal of Chemical Neuroanatomy. 10: 179-90. PMID 8811421 DOI: 10.1016/0891-0618(96)00148-2  0.546
1996 Lam HH, Hanley DF, Trapp BD, Saito S, Raja S, Dawson TM, Yamaguchi H. Induction of spinal cord neuronal nitric oxide synthase (NOS) after formalin injection in the rat hind paw. Neuroscience Letters. 210: 201-4. PMID 8805130 DOI: 10.1016/0304-3940(96)12702-6  0.307
1996 Dawson VL, Kizushi VM, Huang PL, Snyder SH, Dawson TM. Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 2479-87. PMID 8786424  0.457
1996 Burnett AL, Nelson RJ, Calvin DC, Liu JX, Demas GE, Klein SL, Kriegsfeld LJ, Dawson VL, Dawson TM, Snyder SH. Nitric oxide-dependent penile erection in mice lacking neuronal nitric oxide synthase. Molecular Medicine (Cambridge, Mass.). 2: 288-96. PMID 8784782 DOI: 10.1007/Bf03401627  0.69
1996 Dawson TM, Dawson VL. Generation of isoform-specific antibodies to nitric oxide synthases. Methods in Enzymology. 268: 349-58. PMID 8782601 DOI: 10.1016/S0076-6879(96)68037-9  0.452
1996 Dawson TM, Dawson VL. Nitric oxide synthase: role as a transmitter/mediator in the brain and endocrine system. Annual Review of Medicine. 47: 219-27. PMID 8712777 DOI: 10.1146/Annurev.Med.47.1.219  0.493
1996 Xia Y, Dawson VL, Dawson TM, Snyder SH, Zweier JL. Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury. Proceedings of the National Academy of Sciences of the United States of America. 93: 6770-4. PMID 8692893 DOI: 10.1073/Pnas.93.13.6770  0.603
1996 Bao J, Sharp AH, Wagster MV, Becher M, Schilling G, Ross CA, Dawson VL, Dawson TM. Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin. Proceedings of the National Academy of Sciences of the United States of America. 93: 5037-42. PMID 8643525 DOI: 10.1073/Pnas.93.10.5037  0.6
1996 Li XJ, Sharp AH, Li SH, Dawson TM, Snyder SH, Ross CA. Huntingtin-associated protein (HAP1): discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. 93: 4839-44. PMID 8643490 DOI: 10.1073/Pnas.93.10.4839  0.663
1996 Przedborski S, Jackson-Lewis V, Yokoyama R, Shibata T, Dawson VL, Dawson TM. Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 93: 4565-71. PMID 8643444 DOI: 10.1073/Pnas.93.10.4565  0.611
1996 Pluta RM, Thompson BG, Dawson TM, Snyder SH, Boock RJ, Oldfield EH. Loss of nitric oxide synthase immunoreactivity in cerebral vasospasm. Journal of Neurosurgery. 84: 648-54. PMID 8613858 DOI: 10.3171/Jns.1996.84.4.0648  0.476
1996 Dawson VL, Dawson TM. Nitric oxide in neuronal degeneration. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 211: 33-40. PMID 8594616 DOI: 10.3181/00379727-211-43950E  0.55
1996 Resink A, Dawson VL, Dawson TM. Nitric Oxide Synthase Inhibitors Cns Drugs. 6: 351-357. DOI: 10.2165/00023210-199606050-00002  0.501
1996 Dawson V, Kizushi V, Huang P, Snyder S, Dawson T. Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice The Journal of Neuroscience. 16: 2479-2487. DOI: 10.1523/Jneurosci.16-08-02479.1996  0.637
1996 Dawson VL, Dawson TM. [2] Nitric oxide toxicity in central nervous system cultures Methods in Neurosciences. 30: 26-43. DOI: 10.1016/S1043-9471(96)80094-2  0.462
1996 Dawson VL, Dawson TM. [20] Function of nitric oxide in neuronal cell death Methods in Neurosciences. 31: 228-240. DOI: 10.1016/S1043-9471(96)80023-1  0.537
1996 Dawson TM, Dawson VL. [6] NADPH Diaphorase staining Methods in Neurosciences. 31: 62-67. DOI: 10.1016/S1043-9471(96)80009-7  0.447
1996 Steiner JP, Dawson TM, Fotuhi M, Snyder SH. Immunophilin Regulation of Neurotransmitter Release Molecular Medicine. 2: 325-333. DOI: 10.1007/Bf03401630  0.522
1995 Dawson VL, Dawson TM. Physiological and toxicological actions of nitric oxide in the central nervous system. Advances in Pharmacology (San Diego, Calif.). 34: 323-42. PMID 8562443 DOI: 10.1016/S1054-3589(08)61095-9  0.538
1995 Dawson TM, Dawson VL. ADP-ribosylation as a mechanism for the action of nitric oxide in the nervous system. New Horizons (Baltimore, Md.). 3: 85-92. PMID 7704595  0.491
1995 Linden DJ, Dawson TM, Dawson VL. An evaluation of the nitric oxide/cGMP/cGMP-dependent protein kinase cascade in the induction of cerebellar long-term depression in culture. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 5098-105. PMID 7623138 DOI: 10.1523/Jneurosci.15-07-05098.1995  0.518
1995 Irikura K, Huang PL, Ma J, Lee WS, Dalkara T, Fishman MC, Dawson TM, Snyder SH, Moskowitz MA. Cerebrovascular alterations in mice lacking neuronal nitric oxide synthase gene expression. Proceedings of the National Academy of Sciences of the United States of America. 92: 6823-7. PMID 7542777 DOI: 10.1073/Pnas.92.15.6823  0.536
1995 Dawson TM, Hung K, Dawson VL, Steiner JP, Snyder SH. Neuroprotective effects of gangliosides may involve inhibition of nitric oxide synthase. Annals of Neurology. 37: 115-8. PMID 7529474 DOI: 10.1002/Ana.410370122  0.629
1995 Nelson RJ, Demas GE, Huang PL, Fishman MC, Dawson VL, Dawson TM, Snyder SH. Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase. Nature. 378: 383-6. PMID 7477374 DOI: 10.1038/378383A0  0.685
1995 Lyons W, Steiner J, Snyder S, Dawson T. Neuronal regeneration enhances the expression of the immunophilin FKBP- 12 The Journal of Neuroscience. 15: 2985-2994. DOI: 10.1523/Jneurosci.15-04-02985.1995  0.53
1995 Dawson TM, Dawson VL. Review ■ Nitric Oxide: Actions and Pathological Roles The Neuroscientist. 1: 7-18. DOI: 10.1177/107385849500100103  0.506
1994 Zhang J, Dawson VL, Dawson TM, Snyder SH. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science (New York, N.Y.). 263: 687-9. PMID 8080500 DOI: 10.1126/Science.8080500  0.63
1994 Dawson VL, Hsu CY, Liu TH, Dawson TM, Wamsley JK. Receptor alterations in subcortical structures after bilateral middle cerebral artery infarction of the cerebral cortex. Experimental Neurology. 128: 88-96. PMID 8070526 DOI: 10.1006/Exnr.1994.1115  0.478
1994 Lynch DR, Dawson TM. Secondary mechanisms in neuronal trauma Current Opinion in Neurology. 7: 510-516. PMID 7866582 DOI: 10.1097/00019052-199412000-00007  0.48
1994 Dawson TM, Dawson VL, Snyder SH. Molecular mechanisms of nitric oxide actions in the brain. Annals of the New York Academy of Sciences. 738: 76-85. PMID 7832458 DOI: 10.1111/J.1749-6632.1994.Tb21792.X  0.597
1994 Dawson TM, Zhang J, Dawson VL, Snyder SH. Nitric oxide: cellular regulation and neuronal injury. Progress in Brain Research. 103: 365-9. PMID 7533914 DOI: 10.1016/S0079-6123(08)61150-4  0.658
1994 Dawson TM, Dawson VL. gp120 neurotoxicity in primary cortical cultures. Advances in Neuroimmunology. 4: 167-73. PMID 7533039 DOI: 10.1016/S0960-5428(06)80253-6  0.489
1994 Dawson VL, Brahmbhatt HP, Mong JA, Dawson TM. Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures. Neuropharmacology. 33: 1425-30. PMID 7532825 DOI: 10.1016/0028-3908(94)90045-0  0.519
1994 Dinerman JL, Steiner JP, Dawson TM, Dawson V, Snyder SH. Cyclic nucleotide dependent phosphorylation of neuronal nitric oxide synthase inhibits catalytic activity. Neuropharmacology. 33: 1245-51. PMID 7532810 DOI: 10.1016/0028-3908(94)90023-X  0.633
1994 Wu W, Liuzzi FJ, Schinco FP, Depto AS, Li Y, Mong JA, Dawson TM, Snyder SH. Neuronal nitric oxide synthase is induced in spinal neurons by traumatic injury. Neuroscience. 61: 719-26. PMID 7530816 DOI: 10.1016/0306-4522(94)90394-8  0.546
1994 Kovách AG, Lohinai Z, Marczis J, Balla I, Dawson TM, Snyder SH. The effect of hemorrhagic hypotension and retransfusion and 7-nitro-indazole on rCBF, NOS catalytic activity, and cortical NO content in the cat. Annals of the New York Academy of Sciences. 738: 348-68. PMID 7530422 DOI: 10.1111/j.1749-6632.1994.tb21822.x  0.396
1994 Dawson TM, Steiner JP, Lyons WE, Fotuhi M, Blue M, Snyder SH. The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: relationship to calcineurin. Neuroscience. 62: 569-80. PMID 7530348 DOI: 10.1016/0306-4522(94)90389-1  0.502
1994 Roskams AJ, Bredt DS, Dawson TM, Ronnett GV. Nitric oxide mediates the formation of synaptic connections in developing and regenerating olfactory receptor neurons. Neuron. 13: 289-99. PMID 7520251 DOI: 10.1016/0896-6273(94)90347-6  0.554
1994 O'Dell TJ, Huang PL, Dawson TM, Dinerman JL, Snyder SH, Kandel ER, Fishman MC. Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS. Science (New York, N.Y.). 265: 542-6. PMID 7518615 DOI: 10.1126/Science.7518615  0.531
1994 Saito S, Kidd GJ, Trapp BD, Dawson TM, Bredt DS, Wilson DA, Traystman RJ, Snyder SH, Hanley DF. Rat spinal cord neurons contain nitric oxide synthase. Neuroscience. 59: 447-56. PMID 7516502 DOI: 10.1016/0306-4522(94)90608-4  0.652
1994 Dinerman JL, Dawson TM, Schell MJ, Snowman A, Snyder SH. Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America. 91: 4214-8. PMID 7514300 DOI: 10.1073/Pnas.91.10.4214  0.641
1994 Lyons WE, George EB, Dawson TM, Steiner JP, Snyder SH. Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia. Proceedings of the National Academy of Sciences of the United States of America. 91: 3191-5. PMID 7512727 DOI: 10.1073/Pnas.91.8.3191  0.51
1994 Dawson T, Snyder S. Gases as biological messengers: nitric oxide and carbon monoxide in the brain The Journal of Neuroscience. 14: 5147-5159. DOI: 10.1523/Jneurosci.14-09-05147.1994  0.526
1993 Hirsch DB, Steiner JP, Dawson TM, Mammen A, Hayek E, Snyder SH. Neurotransmitter release regulated by nitric oxide in PC-12 cells and brain synaptosomes. Current Biology : Cb. 3: 749-54. PMID 15335838 DOI: 10.1016/0960-9822(93)90022-G  0.516
1993 Sharp AH, Dawson TM, Ross CA, Fotuhi M, Mourey RJ, Snyder SH. Inositol 1,4,5-trisphosphate receptors: immunohistochemical localization to discrete areas of rat central nervous system. Neuroscience. 53: 927-42. PMID 8389431 DOI: 10.1016/0306-4522(93)90478-X  0.595
1993 Dawson VL, Dawson TM, Uhl GR, Snyder SH. Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures. Proceedings of the National Academy of Sciences of the United States of America. 90: 3256-9. PMID 8097316 DOI: 10.1073/Pnas.90.8.3256  0.624
1993 Dawson TM, Steiner JP, Dawson VL, Dinerman JL, Uhl GR, Snyder SH. Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 90: 9808-12. PMID 7694293 DOI: 10.1073/Pnas.90.21.9808  0.625
1993 Dawson VL, Dawson TM, Bartley DA, Uhl GR, Snyder SH. Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 2651-61. PMID 7684776 DOI: 10.1523/Jneurosci.13-06-02651.1993  0.541
1993 Nozaki K, Moskowitz MA, Maynard KI, Koketsu N, Dawson TM, Bredt DS, Snyder SH. Possible origins and distribution of immunoreactive nitric oxide synthase-containing nerve fibers in cerebral arteries. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 13: 70-9. PMID 7678014 DOI: 10.1038/Jcbfm.1993.9  0.628
1993 Yamamoto R, Bredt DS, Dawson TM, Snyder SH, Stone RA. Enhanced expression of nitric oxide synthase by rat retina following pterygopalatine parasympathetic denervation. Brain Research. 631: 83-8. PMID 7507791 DOI: 10.1016/0006-8993(93)91190-4  0.62
1993 Dawson TM, Dawson VL, Snyder SH. Nitric oxide as a mediator of neurotoxicity. Nida Research Monograph. 136: 258-71; discussion 2. PMID 7507221  0.399
1993 Huang PL, Dawson TM, Bredt DS, Snyder SH, Fishman MC. Targeted disruption of the neuronal nitric oxide synthase gene. Cell. 75: 1273-86. PMID 7505721 DOI: 10.1016/0092-8674(93)90615-W  0.687
1993 Fotuhi M, Dawson T, Sharp A, Martin L, Graybiel A, Snyder S. Phosphoinositide second messenger system is enriched in striosomes: immunohistochemical demonstration of inositol 1,4,5-trisphosphate receptors and phospholipase C beta and gamma in primate basal ganglia The Journal of Neuroscience. 13: 3300-3308. DOI: 10.1523/Jneurosci.13-08-03300.1993  0.53
1993 Sharp A, McPherson P, Dawson T, Aoki C, Campbell K, Snyder S. Differential immunohistochemical localization of inositol 1,4,5- trisphosphate- and ryanodine-sensitive Ca2+ release channels in rat brain The Journal of Neuroscience. 13: 3051-3063. DOI: 10.1523/Jneurosci.13-07-03051.1993  0.491
1993 Dawson V, Dawson T, Bartley D, Uhl G, Snyder S. Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures The Journal of Neuroscience. 13: 2651-2661. DOI: 10.1523/JNEUROSCI.13-06-02651.1993  0.564
1993 Fotuhi M, Sharp A, Glatt C, Hwang P, von Krosigk M, Snyder S, Dawson T. Differential localization of phosphoinositide-linked metabotropic glutamate receptor (mGluR1) and the inositol 1,4,5-trisphosphate receptor in rat brain The Journal of Neuroscience. 13: 2001-2012. DOI: 10.1523/Jneurosci.13-05-02001.1993  0.52
1992 Dawson TM, Dawson VL, Snyder SH. A novel neuronal messenger molecule in brain: the free radical, nitric oxide. Annals of Neurology. 32: 297-311. PMID 1384420 DOI: 10.1002/Ana.410320302  0.647
1992 Steiner JP, Dawson TM, Fotuhi M, Glatt CE, Snowman AM, Cohen N, Snyder SH. High brain densities of the immunophilin FKBP colocalized with calcineurin. Nature. 358: 584-7. PMID 1380130 DOI: 10.1038/358584A0  0.697
1992 Lynch DR, Dawson TM, Raps EC, Galetta SL. Risk Factors for the Neurologic Complications Associated with Aortic Aneurysms Archives of Neurology. 49: 284-288. PMID 1311168 DOI: 10.1001/Archneur.1992.00530270098025  0.336
1992 Hyman BT, Marzloff K, Wenniger JJ, Dawson TM, Bredt DS, Snyder SH. Relative sparing of nitric oxide synthase-containing neurons in the hippocampal formation in Alzheimer's disease. Annals of Neurology. 32: 818-20. PMID 1281971 DOI: 10.1002/Ana.410320618  0.695
1991 Dawson TM, Dawson VL, Gage FH, Fisher LJ, Hunt MA, Wamsley JK. Downregulation of muscarinic receptors in the rat caudate-putamen after lesioning of the ipsilateral nigrostriatal dopamine pathway with 6-hydroxydopamine (6-OHDA): normalization by fetal mesencephalic transplants. Brain Research. 540: 145-52. PMID 1905173 DOI: 10.1016/0006-8993(91)90501-L  0.386
1991 Dawson TM, Dawson VL, Gage FH, Fisher LJ, Hunt MA, Wamsley JK. Functional recovery of supersensitive dopamine receptors after intrastriatal grafts of fetal substantia nigra. Experimental Neurology. 111: 282-92. PMID 1825638 DOI: 10.1016/0014-4886(91)90095-T  0.415
1991 Wamsley JK, Dawson TM, Dawson VL, Hunt MA, Fisher LJ, Gage FH. Reversal of nigrostriatal-lesion-induced receptor alterations by grafting of fetal mesencephalic dopaminergic neurons. Advances in Experimental Medicine and Biology. 287: 221-35. PMID 1759609 DOI: 10.1007/978-1-4684-5907-4_18  0.432
1991 Bredt DS, Glatt CE, Hwang PM, Fotuhi M, Dawson TM, Snyder SH. Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron. 7: 615-24. PMID 1718335 DOI: 10.1016/0896-6273(91)90374-9  0.764
1991 Dawson TM, Bredt DS, Fotuhi M, Hwang PM, Snyder SH. Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proceedings of the National Academy of Sciences of the United States of America. 88: 7797-801. PMID 1715581 DOI: 10.1073/Pnas.88.17.7797  0.685
1991 Dawson VL, Dawson TM, London ED, Bredt DS, Snyder SH. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proceedings of the National Academy of Sciences of the United States of America. 88: 6368-71. PMID 1648740 DOI: 10.1073/Pnas.88.14.6368  0.704
1990 Dawson VL, Dawson TM, Wamsley JK. Muscarinic and dopaminergic receptor subtypes on striatal cholinergic interneurons. Brain Research Bulletin. 25: 903-12. PMID 2149667 DOI: 10.1016/0361-9230(90)90186-4  0.413
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