| Year |
Citation |
Score |
| 2024 |
Chen LJ, Li JY, Nguyen P, He M, Chen ZB, Subramaniam S, Shyy JY, Chien S. Single-cell RNA sequencing unveils unique transcriptomic signatures of endothelial cells and role of ENO1 in response to disturbed flow. Proceedings of the National Academy of Sciences of the United States of America. 121: e2318904121. PMID 38261622 DOI: 10.1073/pnas.2318904121 |
0.311 |
|
| 2021 |
Han Y, He M, Marin T, Shen H, Wang WT, Lee TY, Hong HC, Jiang ZL, Garland T, Shyy JY, Gongol B, Chien S. Roles of KLF4 and AMPK in the inhibition of glycolysis by pulsatile shear stress in endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34001623 DOI: 10.1073/pnas.2103982118 |
0.387 |
|
| 2021 |
Zhao Z, Zhao Y, Zhang Y, Shi W, Li X, Shyy JY, He M, Wang L. Gout-induced endothelial impairment: The role of SREBP2 transactivation of YAP. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21613. PMID 33977576 DOI: 10.1096/fj.202100337R |
0.317 |
|
| 2021 |
Lopez-Ramirez MA, McCurdy S, Li W, Haynes MK, Hale P, Francisco K, Oukoloff K, Bautista M, Choi CHJ, Sun H, Gongol B, Shyy JY, Ballatore C, Sklar LA, Gingras AR. Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells. Faseb Bioadvances. 3: 334-355. PMID 33977234 DOI: 10.1096/fba.2020-00141 |
0.336 |
|
| 2020 |
Shen H, Zhang J, Wang C, Jain PP, Xiong M, Shi X, Lei Y, Chen S, Yin Q, Thistlethwaite PA, Wang J, Gong K, Yuan ZY, Yuan JX, Shyy JY. MDM2-Mediated Ubiquitination of ACE2 Contributes to the Development of Pulmonary Arterial Hypertension. Circulation. PMID 32755395 DOI: 10.1161/Circulationaha.120.048191 |
0.349 |
|
| 2018 |
Lai B, Li Z, He M, Wang Y, Chen L, Zhang J, Yang Y, Shyy JY. Atheroprone flow enhances the endothelial-to-mesenchymal transition. American Journal of Physiology. Heart and Circulatory Physiology. PMID 30052471 DOI: 10.1152/Ajpheart.00213.2018 |
0.447 |
|
| 2018 |
Bai L, Shyy JY. Shear Stress Regulation of Endothelium: A Double-edged Sword. Journal of Translational Internal Medicine. 6: 58-61. PMID 29984197 DOI: 10.2478/Jtim-2018-0019 |
0.328 |
|
| 2017 |
Ajami NE, Gupta S, Maurya MR, Nguyen P, Li JY, Shyy JY, Chen Z, Chien S, Subramaniam S. Systems biology analysis of longitudinal functional response of endothelial cells to shear stress. Proceedings of the National Academy of Sciences of the United States of America. PMID 28973892 DOI: 10.1073/Pnas.1707517114 |
0.326 |
|
| 2017 |
Huang TS, Wang KC, Quon S, Nguyen P, Chang TY, Chen Z, Li YS, Subramaniam S, Shyy JY, Chien S. LINC00341 exerts an anti-inflammatory effect on endothelial cells by repressing VCAM1. Physiological Genomics. physiolgenomics.0013. PMID 28500253 DOI: 10.1152/Physiolgenomics.00132.2016 |
0.421 |
|
| 2017 |
Marin TL, Gongol B, Zhang F, Martin M, Johnson DA, Xiao H, Wang Y, Subramaniam S, Chien S, Shyy JY. AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1. Science Signaling. 10. PMID 28143904 DOI: 10.1126/Scisignal.Aaf7478 |
0.303 |
|
| 2016 |
Lin TY, Wei TW, Li S, Wang SC, He M, Martin M, Zhang J, Shentu TP, Xiao H, Kang J, Wang KC, Chen Z, Chien S, Tsai MD, Shyy JY. TIFA as a crucial mediator for NLRP3 inflammasome. Proceedings of the National Academy of Sciences of the United States of America. PMID 27965388 DOI: 10.1073/Pnas.1618773114 |
0.322 |
|
| 2016 |
Shentu TP, He M, Sun X, Zhang J, Zhang F, Gongol B, Marin TL, Zhang J, Wen L, Wang Y, Geary GG, Zhu Y, Johnson DA, Shyy JY. AMP-Activated Protein Kinase and Sirtuin 1 Coregulation of Cortactin Contributes to Endothelial Function. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 27758765 DOI: 10.1161/Atvbaha.116.307871 |
0.395 |
|
| 2016 |
Shang F, Zhang J, Li Z, Zhang J, Yin Y, Wang Y, Marin TL, Gongol B, Xiao H, Zhang YY, Chen Z, Shyy JY, Lei T. Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade. Plos One. 11: e0151845. PMID 26986624 DOI: 10.1371/journal.pone.0151845 |
0.625 |
|
| 2015 |
Marin TL, Gongol B, Martin M, King SJ, Smith L, Johnson DA, Subramaniam S, Chien S, Shyy JY. Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteome. Bmc Systems Biology. 9: 13. PMID 25890336 DOI: 10.1186/S12918-015-0156-0 |
0.592 |
|
| 2014 |
Chen Z, Martin M, Li Z, Shyy JY. Endothelial dysfunction: the role of sterol regulatory element-binding protein-induced NOD-like receptor family pyrin domain-containing protein 3 inflammasome in atherosclerosis. Current Opinion in Lipidology. 25: 339-49. PMID 25188917 DOI: 10.1097/Mol.0000000000000107 |
0.401 |
|
| 2013 |
Wang X, Fang X, Zhou J, Chen Z, Zhao B, Xiao L, Liu A, Li YS, Shyy JY, Guan Y, Chien S, Wang N. Shear stress activation of nuclear receptor PXR in endothelial detoxification. Proceedings of the National Academy of Sciences of the United States of America. 110: 13174-9. PMID 23878263 DOI: 10.1073/pnas.1312065110 |
0.365 |
|
| 2013 |
Xiao H, Lu M, Lin TY, Chen Z, Chen G, Wang WC, Marin T, Shentu TP, Wen L, Gongol B, Sun W, Liang X, Chen J, Huang HD, Pedra JH, ... ... Shyy JY, et al. Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility. Circulation. 128: 632-42. PMID 23838163 DOI: 10.1161/Circulationaha.113.002714 |
0.449 |
|
| 2013 |
Wen L, Chen Z, Zhang F, Cui X, Sun W, Geary GG, Wang Y, Johnson DA, Zhu Y, Chien S, Shyy JY. Ca2+/calmodulin-dependent protein kinase kinase β phosphorylation of Sirtuin 1 in endothelium is atheroprotective. Proceedings of the National Academy of Sciences of the United States of America. 110: E2420-7. PMID 23754392 DOI: 10.1073/Pnas.1309354110 |
0.387 |
|
| 2013 |
Zhou J, Li YS, Nguyen P, Wang KC, Weiss A, Kuo YC, Chiu JJ, Shyy JY, Chien S. Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: role of shear stress. Circulation Research. 113: 40-51. PMID 23603512 DOI: 10.1161/Circresaha.113.280883 |
0.329 |
|
| 2013 |
Chen Z, Lai TC, Jan YH, Lin FM, Wang WC, Xiao H, Wang YT, Sun W, Cui X, Li YS, Fang T, Zhao H, Padmanabhan C, Sun R, Wang DL, ... ... Shyy JY, et al. Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis. The Journal of Clinical Investigation. 123: 1057-67. PMID 23426184 DOI: 10.1172/Jci65344 |
0.366 |
|
| 2013 |
Gongol B, Marin T, Peng IC, Woo B, Martin M, King S, Sun W, Johnson DA, Chien S, Shyy JY. AMPKα2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6. Proceedings of the National Academy of Sciences of the United States of America. 110: 3161-6. PMID 23382195 DOI: 10.1073/Pnas.1222051110 |
0.632 |
|
| 2012 |
Peng IC, Chen Z, Sun W, Li YS, Marin TL, Hsu PH, Su MI, Cui X, Pan S, Lytle CY, Johnson DA, Blaeser F, Chatila T, Shyy JY. Glucagon regulates ACC activity in adipocytes through the CAMKKβ/AMPK pathway. American Journal of Physiology. Endocrinology and Metabolism. 302: E1560-8. PMID 22454291 DOI: 10.1152/Ajpendo.00504.2011 |
0.637 |
|
| 2011 |
Wu W, Xiao H, Laguna-Fernandez A, Villarreal G, Wang KC, Geary GG, Zhang Y, Wang WC, Huang HD, Zhou J, Li YS, Chien S, Garcia-Cardena G, Shyy JY. Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a. Circulation. 124: 633-41. PMID 21768538 DOI: 10.1161/Circulationaha.110.005108 |
0.501 |
|
| 2010 |
Zheng S, Li W, Xu M, Bai X, Zhou Z, Han J, Shyy JY, Wang X. Calcitonin gene-related peptide promotes angiogenesis via AMP-activated protein kinase. American Journal of Physiology. Cell Physiology. 299: C1485-92. PMID 20881236 DOI: 10.1152/ajpcell.00173.2010 |
0.393 |
|
| 2010 |
Wang P, Jiang Y, Wang Y, Shyy JY, DeFea KA. Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2. Bmc Biochemistry. 11: 36. PMID 20858278 DOI: 10.1186/1471-2091-11-36 |
0.418 |
|
| 2010 |
Chen Z, Peng IC, Cui X, Li YS, Chien S, Shyy JY. Shear stress, SIRT1, and vascular homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 107: 10268-73. PMID 20479254 DOI: 10.1073/Pnas.1003833107 |
0.666 |
|
| 2009 |
Young A, Wu W, Sun W, Benjamin Larman H, Larman HB, Wang N, Li YS, Shyy JY, Chien S, García-Cardeña G. Flow activation of AMP-activated protein kinase in vascular endothelium leads to Krüppel-like factor 2 expression. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 1902-8. PMID 19696400 DOI: 10.1161/Atvbaha.109.193540 |
0.519 |
|
| 2009 |
Chen Z, Peng IC, Sun W, Su MI, Hsu PH, Fu Y, Zhu Y, DeFea K, Pan S, Tsai MD, Shyy JY. AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633. Circulation Research. 104: 496-505. PMID 19131647 DOI: 10.1161/Circresaha.108.187567 |
0.639 |
|
| 2009 |
Ai D, Pang W, Li N, Xu M, Jones PD, Yang J, Zhang Y, Chiamvimonvat N, Shyy JY, Hammock BD, Zhu Y. Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy. Proceedings of the National Academy of Sciences of the United States of America. 106: 564-9. PMID 19126686 DOI: 10.1073/Pnas.0811022106 |
0.47 |
|
| 2008 |
Li X, Han Y, Pang W, Li C, Xie X, Shyy JY, Zhu Y. AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 1789-95. PMID 18599796 DOI: 10.1161/ATVBAHA.108.172452 |
0.347 |
|
| 2008 |
Yao M, Zhou R, Petreaca M, Shyy J, Martins‐Green M. 056 Activation of Sterol Regulatory Element‐Binding Proteins ((SREBPs) is Critical in IL‐8‐Induced Angigiogenesi Wound Repair and Regeneration. 13. DOI: 10.1111/J.1067-1927.2005.130215Bd.X |
0.347 |
|
| 2007 |
Guo D, Chien S, Shyy JY. Regulation of endothelial cell cycle by laminar versus oscillatory flow: distinct modes of interactions of AMP-activated protein kinase and Akt pathways. Circulation Research. 100: 564-71. PMID 17272808 DOI: 10.1161/01.RES.0000259561.23876.c5 |
0.372 |
|
| 2006 |
Sun W, Lee TS, Zhu M, Gu C, Wang Y, Zhu Y, Shyy JY. Statins activate AMP-activated protein kinase in vitro and in vivo. Circulation. 114: 2655-62. PMID 17116771 DOI: 10.1161/Circulationaha.106.630194 |
0.51 |
|
| 2006 |
Yao M, Zhou RH, Petreaca M, Zheng L, Shyy J, Martins-Green M. Activation of sterol regulatory element-binding proteins (SREBPs) is critical in IL-8-induced angiogenesis. Journal of Leukocyte Biology. 80: 608-20. PMID 16849610 DOI: 10.1189/Jlb.0304175 |
0.359 |
|
| 2006 |
Zhang Y, Lee TS, Kolb EM, Sun K, Lu X, Sladek FM, Kassab GS, Garland T, Shyy JY. AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 1281-7. PMID 16601232 DOI: 10.1161/01.Atv.0000221230.08596.98 |
0.642 |
|
| 2005 |
Liu Y, Zhang Y, Schmelzer K, Lee TS, Fang X, Zhu Y, Spector AA, Gill S, Morisseau C, Hammock BD, Shyy JY. The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proceedings of the National Academy of Sciences of the United States of America. 102: 16747-52. PMID 16267130 DOI: 10.1073/Pnas.0508081102 |
0.559 |
|
| 2004 |
Liu Y, Zhu Y, Rannou F, Lee TS, Formentin K, Zeng L, Yuan X, Wang N, Chien S, Forman BM, Shyy JY. Laminar flow activates peroxisome proliferator-activated receptor-gamma in vascular endothelial cells. Circulation. 110: 1128-33. PMID 15313948 DOI: 10.1161/01.CIR.0000139850.08365.EC |
0.314 |
|
| 2004 |
Zhou RH, Yao M, Lee TS, Zhu Y, Martins-Green M, Shyy JY. Vascular endothelial growth factor activation of sterol regulatory element binding protein: a potential role in angiogenesis. Circulation Research. 95: 471-8. PMID 15271857 DOI: 10.1161/01.Res.0000139956.42923.4A |
0.324 |
|
| 2004 |
Zeng L, Lu M, Mori K, Luo S, Lee AS, Zhu Y, Shyy JY. ATF6 modulates SREBP2-mediated lipogenesis. The Embo Journal. 23: 950-8. PMID 14765107 DOI: 10.1038/Sj.Emboj.7600106 |
0.308 |
|
| 2004 |
Wang Y, Chang J, Li YC, Li YS, Shyy JY, Chien S. Shear stress and VEGF activate IKK via the Flk-1/Cbl/Akt signaling pathway. American Journal of Physiology. Heart and Circulatory Physiology. 286: H685-92. PMID 14551058 DOI: 10.1152/Ajpheart.00237.2003 |
0.373 |
|
| 2003 |
Lin T, Zeng L, Liu Y, DeFea K, Schwartz MA, Chien S, Shyy JY. Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins. Circulation Research. 92: 1296-304. PMID 12775580 DOI: 10.1161/01.Res.0000078780.65824.8B |
0.375 |
|
| 2003 |
Zeng L, Zhang Y, Chien S, Liu X, Shyy JY. The role of p53 deacetylation in p21Waf1 regulation by laminar flow. The Journal of Biological Chemistry. 278: 24594-9. PMID 12716906 DOI: 10.1074/Jbc.M301955200 |
0.535 |
|
| 2002 |
Wang Y, Miao H, Li S, Chen KD, Li YS, Yuan S, Shyy JY, Chien S. Interplay between integrins and FLK-1 in shear stress-induced signaling. American Journal of Physiology. Cell Physiology. 283: C1540-7. PMID 12372815 DOI: 10.1152/Ajpcell.00222.2002 |
0.386 |
|
| 2002 |
Liu Y, Chen BP, Lu M, Zhu Y, Stemerman MB, Chien S, Shyy JY. Shear stress activation of SREBP1 in endothelial cells is mediated by integrins. Arteriosclerosis, Thrombosis, and Vascular Biology. 22: 76-81. PMID 11788464 DOI: 10.1161/Hq0102.101822 |
0.352 |
|
| 2001 |
Zhu Y, Liao H, Wang N, Ma KS, Verna LK, Shyy JY, Chien S, Stemerman MB. LDL-activated p38 in endothelial cells is mediated by Ras. Arteriosclerosis, Thrombosis, and Vascular Biology. 21: 1159-64. PMID 11451745 DOI: 10.1161/Hq0701.092473 |
0.319 |
|
| 2001 |
Jin G, Sah RL, Li YS, Lotz M, Shyy JY, Chien S. Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 18: 899-908. PMID 11192249 DOI: 10.1002/Jor.1100180608 |
0.401 |
|
| 2000 |
Lin K, Hsu PP, Chen BP, Yuan S, Usami S, Shyy JY, Li YS, Chien S. Molecular mechanism of endothelial growth arrest by laminar shear stress. Proceedings of the National Academy of Sciences of the United States of America. 97: 9385-9. PMID 10920209 DOI: 10.1073/pnas.170282597 |
0.349 |
|
| 1999 |
Hu YL, Li S, Shyy JY, Chien S. Sustained JNK activation induces endothelial apoptosis: studies with colchicine and shear stress. The American Journal of Physiology. 277: H1593-9. PMID 10516199 DOI: 10.1152/Ajpheart.1999.277.4.H1593 |
0.313 |
|
| 1999 |
Chen KD, Li YS, Kim M, Li S, Yuan S, Chien S, Shyy JY. Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc. The Journal of Biological Chemistry. 274: 18393-400. PMID 10373445 DOI: 10.1074/Jbc.274.26.18393 |
0.452 |
|
| 1998 |
Jalali S, Li YS, Sotoudeh M, Yuan S, Li S, Chien S, Shyy JY. Shear stress activates p60src-Ras-MAPK signaling pathways in vascular endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 18: 227-34. PMID 9484987 DOI: 10.1161/01.Atv.18.2.227 |
0.479 |
|
| 1998 |
Chien S, Li S, Shyy JY. Effects of Mechanical Forces on Signal Transduction and Gene Expression in Endothelial Cells Hypertension. 31: 162-169. PMID 9453297 DOI: 10.1161/01.Hyp.31.1.162 |
0.371 |
|
| 1997 |
Chiu JJ, Wung BS, Shyy JY, Hsieh HJ, Wang DL. Reactive oxygen species are involved in shear stress-induced intercellular adhesion molecule-1 expression in endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 3570-7. PMID 9437207 DOI: 10.1161/01.ATV.17.12.3570 |
0.328 |
|
| 1997 |
Li S, Kim M, Hu YL, Jalali S, Schlaepfer DD, Hunter T, Chien S, Shyy JY. Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases. The Journal of Biological Chemistry. 272: 30455-62. PMID 9374537 DOI: 10.1074/Jbc.272.48.30455 |
0.485 |
|
| 1997 |
Shyy JY, Chien S. Role of integrins in cellular responses to mechanical stress and adhesion. Current Opinion in Cell Biology. 9: 707-13. PMID 9330875 DOI: 10.1016/S0955-0674(97)80125-1 |
0.379 |
|
| 1996 |
Li YS, Shyy JY, Li S, Lee J, Su B, Karin M, Chien S. The Ras-JNK pathway is involved in shear-induced gene expression. Molecular and Cellular Biology. 16: 5947-54. PMID 8887624 DOI: 10.1128/Mcb.16.11.5947 |
0.453 |
|
| 1995 |
Shyy JY, Lin MC, Han J, Lu Y, Petrime M, Chien S. The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression. Proceedings of the National Academy of Sciences of the United States of America. 92: 8069-73. PMID 7644539 DOI: 10.1073/pnas.92.17.8069 |
0.354 |
|
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