Peter J. Espenshade - Publications

Affiliations: 
Cell Biology Johns Hopkins University School of Medicine, Baltimore, MD, United States 
Area:
oxygen sensing, sterol sensing, hypoxic response
Website:
http://espenshadelab.com

78 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Ishida CT, Shao W, Espenshade PJ. Assaying Sterol-Regulated ER-to-Golgi Transport of SREBP Cleavage-Activating Protein Using Immunofluorescence Microscopy. Methods in Molecular Biology (Clifton, N.J.). 2557: 755-764. PMID 36512249 DOI: 10.1007/978-1-0716-2639-9_45  0.364
2022 Zhao S, Hughes AL, Espenshade PJ. Fission yeast Dap1 heme iron-coordinating residue Y83 is required for cytochromes P450 function. Micropublication Biology. 2022. PMID 36090151 DOI: 10.17912/micropub.biology.000631  0.573
2020 Shao W, Hwang J, Liu C, Mukhopadhyay D, Zhao S, Shen MC, Alpergin ESS, Wolfgang MJ, Farber SA, Espenshade PJ. Serum lipoprotein-derived fatty acids regulate hypoxia-inducible factor. The Journal of Biological Chemistry. PMID 33109611 DOI: 10.1074/jbc.RA120.015238  0.379
2020 Esquejo RM, Roqueta-Rivera M, Shao W, Phelan PE, Seneviratne U, Am Ende CW, Hershberger PM, Machamer CE, Espenshade PJ, Osborne TF. Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum. Cell Chemical Biology. PMID 33096051 DOI: 10.1016/j.chembiol.2020.10.003  0.408
2019 Gutiérrez MS, Campusano S, González AM, Gómez M, Barahona S, Sepúlveda D, Espenshade PJ, Fernández-Lobato M, Baeza M, Cifuentes V, Alcaíno J. Sterol Regulatory Element-Binding Protein (Sre1) Promotes the Synthesis of Carotenoids and Sterols in . Frontiers in Microbiology. 10: 586. PMID 30984134 DOI: 10.3389/Fmicb.2019.00586  0.546
2017 Clasen SJ, Shao W, Gu H, Espenshade P. Prolyl dihydroxylation of pre-ribosomal uS12/Rps23 regulates fungal hypoxic adaptation. Elife. 6. PMID 29083304 DOI: 10.7554/Elife.28563  0.569
2017 Burr R, Espenshade PJ. Oxygen-responsive transcriptional regulation of lipid homeostasis in fungi: Implications for anti-fungal drug development. Seminars in Cell & Developmental Biology. PMID 28851600 DOI: 10.1016/J.Semcdb.2017.08.043  0.492
2017 Burr R, Ribbens D, Raychaudhuri S, Stewart EV, Ho J, Espenshade PJ. Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of Sterol Regulatory Element-binding Protein in fission yeast. The Journal of Biological Chemistry. PMID 28821619 DOI: 10.1074/Jbc.M117.802025  0.841
2017 Burr R, Stewart EV, Espenshade PJ. Coordinate Regulation of Yeast Sterol Regulatory Element-Binding Protein (SREBP) and Mga2 Transcription Factors. The Journal of Biological Chemistry. PMID 28202541 DOI: 10.1074/Jbc.M117.778209  0.834
2017 Clasen SJ, Shao W, Gu H, Espenshade PJ. Author response: Prolyl dihydroxylation of unassembled uS12/Rps23 regulates fungal hypoxic adaptation Elife. DOI: 10.7554/Elife.28563.019  0.325
2016 Gong X, Qian H, Shao W, Li J, Wu J, Liu JJ, Li W, Wang HW, Espenshade P, Yan N. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell Research. 26: 1197-1211. PMID 27811944 DOI: 10.1038/Cr.2016.123  0.502
2016 Hwang J, Ribbens D, Raychaudhuri S, Cairns L, Gu H, Frost A, Urban S, Espenshade PJ. A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP. The Embo Journal. PMID 27655872 DOI: 10.15252/Embj.201693923  0.548
2016 Shao W, Machamer CE, Espenshade PJ. Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner. Journal of Lipid Research. PMID 27324795 DOI: 10.1194/Jlr.M069583  0.449
2016 Hwang J, Espenshade PJ. Proximity-dependent biotin labeling in yeast using the engineered ascorbate peroxidase APEX2. The Biochemical Journal. PMID 27274088 DOI: 10.1042/Bcj20160106  0.334
2016 Burr R, Stewart EV, Shao W, Zhao S, Hannibal-Bach HK, Ejsing CS, Espenshade PJ. Mga2 Transcription Factor Regulates an Oxygen-Responsive Lipid Homeostasis Pathway in Fission Yeast. The Journal of Biological Chemistry. PMID 27053105 DOI: 10.1074/Jbc.M116.723650  0.841
2015 Shao W, Espenshade PJ. Sugar Makes Fat by Talking to SCAP. Cancer Cell. 28: 548-9. PMID 26555169 DOI: 10.1016/J.Ccell.2015.10.011  0.332
2015 Raychaudhuri S, Espenshade PJ. Endoplasmic Reticulum Exit of Golgi-resident Defective for SREBP Cleavage (Dsc) E3 Ligase Complex Requires Its Activity. The Journal of Biological Chemistry. 290: 14430-40. PMID 25918164 DOI: 10.1074/Jbc.M114.630863  0.394
2015 Gong X, Li J, Shao W, Wu J, Qian H, Ren R, Espenshade P, Yan N. Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition. Cell Research. 25: 401-11. PMID 25771684 DOI: 10.1038/Cr.2015.32  0.438
2014 Tong Z, Kim MS, Pandey A, Espenshade PJ. Identification of candidate substrates for the Golgi Tul1 E3 ligase using quantitative diGly proteomics in yeast. Molecular & Cellular Proteomics : McP. 13: 2871-82. PMID 25078903 DOI: 10.1074/Mcp.M114.040774  0.432
2014 Shao W, Espenshade PJ. Sterol regulatory element-binding protein (SREBP) cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP). The Journal of Biological Chemistry. 289: 7547-57. PMID 24478315 DOI: 10.1074/Jbc.M113.545699  0.519
2014 Brookheart RT, Lee CY, Espenshade PJ. Casein kinase 1 regulates sterol regulatory element-binding protein (SREBP) to control sterol homeostasis. The Journal of Biological Chemistry. 289: 2725-35. PMID 24327658 DOI: 10.1074/Jbc.M113.511899  0.755
2013 Lloyd SJ, Raychaudhuri S, Espenshade PJ. Subunit architecture of the Golgi Dsc E3 ligase required for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. The Journal of Biological Chemistry. 288: 21043-54. PMID 23760507 DOI: 10.1074/Jbc.M113.468215  0.471
2013 Cheung R, Espenshade PJ. Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. The Journal of Biological Chemistry. 288: 20351-60. PMID 23729666 DOI: 10.1074/Jbc.M113.482224  0.538
2012 Shao W, Espenshade PJ. Expanding roles for SREBP in metabolism. Cell Metabolism. 16: 414-9. PMID 23000402 DOI: 10.1016/J.Cmet.2012.09.002  0.47
2012 Porter JR, Lee CY, Espenshade PJ, Iglesias PA. Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation. Molecular Biology of the Cell. 23: 3764-74. PMID 22833559 DOI: 10.1091/Mbc.E12-06-0451  0.79
2012 Raychaudhuri S, Young BP, Espenshade PJ, Loewen C. Regulation of lipid metabolism: a tale of two yeasts. Current Opinion in Cell Biology. 24: 502-8. PMID 22694927 DOI: 10.1016/J.Ceb.2012.05.006  0.385
2012 Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman JI, Jiang L, Kuo D, Tosti E, Kim HS, ... ... Espenshade PJ, et al. Hierarchical modularity and the evolution of genetic interactomes across species. Molecular Cell. 46: 691-704. PMID 22681890 DOI: 10.1016/J.Molcel.2012.05.028  0.319
2012 Porter JR, Burg JS, Espenshade PJ, Iglesias PA. Identifying a static nonlinear structure in a biological system using noisy, sparse data. Journal of Theoretical Biology. 300: 232-41. PMID 22310068 DOI: 10.1016/J.Jtbi.2012.01.037  0.754
2012 Stewart EV, Lloyd SJ, Burg JS, Nwosu CC, Lintner RE, Daza R, Russ C, Ponchner K, Nusbaum C, Espenshade PJ. Yeast sterol regulatory element-binding protein (SREBP) cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase. The Journal of Biological Chemistry. 287: 672-81. PMID 22086920 DOI: 10.1074/Jbc.M111.317370  0.807
2011 Lee CY, Yeh TL, Hughes BT, Espenshade PJ. Regulation of the Sre1 hypoxic transcription factor by oxygen-dependent control of DNA binding. Molecular Cell. 44: 225-34. PMID 22017871 DOI: 10.1016/J.Molcel.2011.08.031  0.837
2011 Burg JS, Espenshade PJ. Regulation of HMG-CoA reductase in mammals and yeast. Progress in Lipid Research. 50: 403-10. PMID 21801748 DOI: 10.1016/J.Plipres.2011.07.002  0.802
2011 Burg JS, Espenshade PJ. Glucose controls phosphoregulation of hydroxymethylglutaryl coenzyme A reductase through the protein phosphatase 2A-related phosphatase protein, Ppe1, and Insig in fission yeast. The Journal of Biological Chemistry. 286: 27139-46. PMID 21680738 DOI: 10.1074/Jbc.M111.233452  0.792
2011 Stewart EV, Nwosu CC, Tong Z, Roguev A, Cummins TD, Kim DU, Hayles J, Park HO, Hoe KL, Powell DW, Krogan NJ, Espenshade PJ. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Molecular Cell. 42: 160-71. PMID 21504829 DOI: 10.1016/J.Molcel.2011.02.035  0.812
2011 Yeh TL, Lee CY, Amzel LM, Espenshade PJ, Bianchet MA. The hypoxic regulator of sterol synthesis nro1 is a nuclear import adaptor. Structure (London, England : 1993). 19: 503-14. PMID 21481773 DOI: 10.1016/J.Str.2011.01.017  0.721
2011 Porter JR, Iglesias PA, Burg JS, Espenshade PJ. Overcoming data limitations to identify a static nonlinearity in a biological signaling cascade 2011 45th Annual Conference On Information Sciences and Systems, Ciss 2011. DOI: 10.1109/CISS.2011.5766151  0.746
2011 Yeh T, Lee CS, Espenshade PJ, Amzel LM, Bianchet MA. Crystal Structure of the C-Terminal Domain of the Hypoxia Regulator Ofd1 Biophysical Journal. 100: 50a-51a. DOI: 10.1016/J.Bpj.2010.12.474  0.714
2010 Porter JR, Burg JS, Espenshade PJ, Iglesias PA. Ergosterol regulates sterol regulatory element binding protein (SREBP) cleavage in fission yeast. The Journal of Biological Chemistry. 285: 41051-61. PMID 20959444 DOI: 10.1074/Jbc.M110.144337  0.849
2010 Bien CM, Espenshade PJ. Sterol regulatory element binding proteins in fungi: hypoxic transcription factors linked to pathogenesis. Eukaryotic Cell. 9: 352-9. PMID 20118213 DOI: 10.1128/Ec.00358-09  0.851
2010 Radhakrishnan A, Sun LP, Espenshade PJ, Goldstein JL, Brown MS. The SREBP pathway. gene regulation through sterol sensing and gated protein trafficking Handbook of Cell Signaling, 2/E. 3: 2505-2510. DOI: 10.1016/B978-0-12-374145-5.00298-9  0.341
2009 Osborne TF, Espenshade PJ. Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been. Genes & Development. 23: 2578-91. PMID 19933148 DOI: 10.1101/Gad.1854309  0.49
2009 Bien CM, Chang YC, Nes WD, Kwon-Chung KJ, Espenshade PJ. Cryptococcus neoformans Site-2 protease is required for virulence and survival in the presence of azole drugs. Molecular Microbiology. 74: 672-90. PMID 19818023 DOI: 10.1111/J.1365-2958.2009.06895.X  0.797
2009 Chang YC, Ingavale SS, Bien C, Espenshade P, Kwon-Chung KJ. Conservation of the sterol regulatory element-binding protein pathway and its pathobiological importance in cryptococcus neoformans Eukaryotic Cell. 8: 1770-1779. PMID 19749173 DOI: 10.1128/Ec.00207-09  0.831
2009 Hughes BT, Nwosu CC, Espenshade PJ. Degradation of sterol regulatory element-binding protein precursor requires the endoplasmic reticulum-associated degradation components Ubc7 and Hrd1 in fission yeast. The Journal of Biological Chemistry. 284: 20512-21. PMID 19520858 DOI: 10.1074/Jbc.M109.002436  0.821
2009 Lee CY, Stewart EV, Hughes BT, Espenshade PJ. Oxygen-dependent binding of Nro1 to the prolyl hydroxylase Ofd1 regulates SREBP degradation in yeast. The Embo Journal. 28: 135-43. PMID 19158663 DOI: 10.1038/Emboj.2008.271  0.832
2008 Burg JS, Powell DW, Chai R, Hughes AL, Link AJ, Espenshade PJ. Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast. Cell Metabolism. 8: 522-31. PMID 19041767 DOI: 10.1016/J.Cmet.2008.09.004  0.821
2008 Hughes AL, Stewart EV, Espenshade PJ. Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP. Journal of Lipid Research. 49: 2001-12. PMID 18503029 DOI: 10.1194/Jlr.M800207-Jlr200  0.811
2008 Hughes BT, Espenshade PJ. Oxygen-regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member. The Embo Journal. 27: 1491-501. PMID 18418381 DOI: 10.1038/Emboj.2008.83  0.785
2008 Sehgal A, Hughes BT, Espenshade PJ. Oxygen-dependent, alternative promoter controls translation of tco1+ in fission yeast. Nucleic Acids Research. 36: 2024-31. PMID 18276645 DOI: 10.1093/Nar/Gkn027  0.794
2007 Sehgal A, Lee CY, Espenshade PJ. SREBP controls oxygen-dependent mobilization of retrotransposons in fission yeast. Plos Genetics. 3: e131. PMID 17696611 DOI: 10.1371/Journal.Pgen.0030131  0.724
2007 Espenshade PJ, Hughes AL. Regulation of sterol synthesis in eukaryotes. Annual Review of Genetics. 41: 401-27. PMID 17666007 DOI: 10.1146/Annurev.Genet.41.110306.130315  0.705
2007 Lee H, Bien CM, Hughes AL, Espenshade PJ, Kwon-Chung KJ, Chang YC. Cobalt chloride, a hypoxia-mimicking agent, targets sterol synthesis in the pathogenic fungus Cryptococcus neoformans. Molecular Microbiology. 65: 1018-33. PMID 17645443 DOI: 10.1111/J.1365-2958.2007.05844.X  0.814
2007 Hughes AL, Lee CY, Bien CM, Espenshade PJ. 4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress. The Journal of Biological Chemistry. 282: 24388-96. PMID 17595166 DOI: 10.1074/Jbc.M701326200  0.81
2007 Chang YC, Bien CM, Lee H, Espenshade PJ, Kwon-Chung KJ. Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans. Molecular Microbiology. 64: 614-29. PMID 17462012 DOI: 10.1111/J.1365-2958.2007.05676.X  0.826
2007 Hughes AL, Powell DW, Bard M, Eckstein J, Barbuch R, Link AJ, Espenshade PJ. Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes. Cell Metabolism. 5: 143-9. PMID 17276356 DOI: 10.1016/J.Cmet.2006.12.009  0.6
2007 Hughes AL, Espenshade PJ. Insig‐independent activation of fission yeast SREBP/SCAP by 4,4‐methyl sterol intermediates The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A609-D  0.603
2007 Burg JS, Bard M, Powell DW, Espenshade PJ. Insig Regulates HMG‐CoA Reductase by a Non‐Degradative Mechanism in Fission Yeast The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A609-C  0.779
2007 Hughes BT, Espenshade PJ. 2‐oxoglutarate‐Fe(II)‐dependent dioxygenase regulates degradation of nuclear sterol regulatory element binding protein in fission yeast The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A609-B  0.755
2007 Bien C, Chang Y, Lee H, Kwon‐Chung J, Espenshade P. Cryptococcus neoformans sterol regulatory element binding protein (Sre1p), a virulence factor that functions in oxygen sensing and sterol homeostasis The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A608-D  0.829
2007 Stewart EV, Espenshade PJ. Development of a selection strategy to identify novel genes involved in the S. pombe SREBP pathway. The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A608-C  0.763
2007 Lee CS, Stewart EV, Espenshade PJ. Genetic screen to identify regulators of nuclear sterol regulatory element binding protein (SREBP) in fission yeast The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A608-B  0.809
2007 Espenshade PJ, Hughes AL, Lee CS, Hughes BT. Oxygen‐dependent regulation of sterol regulatory element binding protein (SREBP) in fission yeast The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A608-A  0.826
2007 Sehgal A, Hughes BT, Bien CM, Espenshade PJ. SREBP regulates translation by promoter selection and formation of RNA secondary structure under anoxia in fission yeast The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A240-A  0.764
2006 Todd BL, Stewart EV, Burg JS, Hughes AL, Espenshade PJ. Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast. Molecular and Cellular Biology. 26: 2817-31. PMID 16537923 DOI: 10.1128/Mcb.26.7.2817-2831.2006  0.82
2006 Espenshade PJ. SREBPs: sterol-regulated transcription factors. Journal of Cell Science. 119: 973-6. PMID 16525117 DOI: 10.1242/Jcs02866  0.495
2005 Hughes AL, Todd BL, Espenshade PJ. SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast. Cell. 120: 831-42. PMID 15797383 DOI: 10.1016/J.Cell.2005.01.012  0.729
2003 Espenshade PJ, Goldstein JL, Brown MS. SREPBs: Gene Regulation through Controlled Protein Trafficking Handbook of Cell Signaling. 3: 353-358. DOI: 10.1016/B978-012124546-7/50686-0  0.311
2002 Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R, Goldstein JL, Brown MS. Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell. 110: 489-500. PMID 12202038 DOI: 10.1016/S0092-8674(02)00872-3  0.427
2002 Espenshade PJ, Li WP, Yabe D. Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER. Proceedings of the National Academy of Sciences of the United States of America. 99: 11694-9. PMID 12193656 DOI: 10.1073/Pnas.182412799  0.427
2000 Nohturfft A, Yabe D, Goldstein JL, Brown MS, Espenshade PJ. Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes. Cell. 102: 315-23. PMID 10975522 DOI: 10.1016/S0092-8674(00)00037-4  0.388
1999 DeBose-Boyd RA, Brown MS, Li WP, Nohturfft A, Goldstein JL, Espenshade PJ. Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. Cell. 99: 703-12. PMID 10619424 DOI: 10.1016/S0092-8674(00)81668-2  0.425
1999 Cheng D, Espenshade PJ, Slaughter CA, Jaen JC, Brown MS, Goldstein JL. Secreted site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins. The Journal of Biological Chemistry. 274: 22805-12. PMID 10428865 DOI: 10.1074/Jbc.274.32.22805  0.377
1999 Espenshade PJ, Cheng D, Goldstein JL, Brown MS. Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins. The Journal of Biological Chemistry. 274: 22795-804. PMID 10428864 DOI: 10.1074/Jbc.274.32.22795  0.37
1999 Roberg KJ, Crotwell M, Espenshade P, Gimeno R, Kaiser CA. LST1 is a SEC24 homologue used for selective export of the plasma membrane ATPase from the endoplasmic reticulum Journal of Cell Biology. 145: 659-672. PMID 10330397 DOI: 10.1083/Jcb.145.4.659  0.364
1998 Sakai J, Rawson RB, Espenshade PJ, Cheng D, Seegmiller AC, Goldstein JL, Brown MS. Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells. Molecular Cell. 2: 505-14. PMID 9809072 DOI: 10.1016/S1097-2765(00)80150-1  0.395
1997 Shaywitz DA, Espenshade PJ, Gimeno RE, Kaiser CA. COPII subunit interactions in the assembly of the vesicle coat. The Journal of Biological Chemistry. 272: 25413-6. PMID 9325247 DOI: 10.1074/Jbc.272.41.25413  0.373
1996 Gimeno RE, Espenshade P, Kaiser CA. COPII coat subunit interactions: Sec24p and Sec23p bind to adjacent regions of Sec16p Molecular Biology of the Cell. 7: 1815-1823. PMID 8930902 DOI: 10.1091/Mbc.7.11.1815  0.385
1995 Gimeno RE, Espenshade P, Kaiser CA. SED4 encodes a yeast endoplasmic reticulum protein that binds Sec16p and participates in vesicle formation Journal of Cell Biology. 131: 325-338. PMID 7593162 DOI: 10.1083/Jcb.131.2.325  0.371
1995 Espenshade P, Gimeno RE, Holzmacher E, Teung P, Kaiser CA. Yeast SEC16 gene encodes a multidomain vesicle coat protein that interacts with Sec23p Journal of Cell Biology. 131: 311-324. PMID 7593161 DOI: 10.1083/Jcb.131.2.311  0.37
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