| Year |
Citation |
Score |
| 2020 |
Yan W, Lakkaniga NR, Carlomagno F, Santoro M, McDonald NQ, Lv F, Gunaganti N, Frett B, Li HY. Correction to Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application. Journal of Medicinal Chemistry. PMID 32841014 DOI: 10.1021/Acs.Jmedchem.0C01351 |
0.315 |
|
| 2020 |
Grey W, Chauhan R, Piganeau M, Huerga Encabo H, Garcia-Albornoz M, McDonald NQ, Bonnet D. Activation of the receptor tyrosine kinase, RET, improves long-term hematopoietic stem cell outgrowth and potency. Blood. PMID 32589703 DOI: 10.1182/Blood.2020006302 |
0.301 |
|
| 2020 |
Moccia M, Frett B, Zhang L, Lakkaniga NR, Briggs DC, Chauhan R, Brescia A, Federico G, Yan W, Santoro M, McDonald NQ, Li HY, Carlomagno F. Bioisosteric discovery of NPA101.3, a second generation RET/VEGFR2 inhibitor optimized for single-agent polypharmacology. Journal of Medicinal Chemistry. PMID 32298114 DOI: 10.1021/Acs.Jmedchem.9B01336 |
0.341 |
|
| 2020 |
Jones M, Beuron F, Borg A, Nans A, Earl CP, Briggs DC, Snijders AP, Bowles M, Morris EP, Linch M, McDonald NQ. Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation. Nature Communications. 11: 1120. PMID 32111838 DOI: 10.1038/S41467-020-14856-2 |
0.332 |
|
| 2019 |
Diring J, Mouilleron S, McDonald NQ, Treisman R. RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability. Nature Cell Biology. PMID 31209295 DOI: 10.1038/S41556-019-0337-Y |
0.316 |
|
| 2019 |
Elbediwy A, Zhang Y, Cobbaut M, Riou P, Tan RS, Roberts SK, Tynan C, George R, Kjaer S, Martin-Fernandez ML, Thompson BJ, McDonald NQ, Parker PJ. The Rho-family GEF FARP2 is activated by aPKCι to control polarity and tight junction formation. Journal of Cell Science. PMID 30872454 DOI: 10.1242/Jcs.223743 |
0.372 |
|
| 2019 |
Grey W, Chauhan R, Garcia-Albornoz M, Encabo HH, McDonald N, Bonnet D. Activation of the Receptor Tyrosine Kinase (RET) By GDNF/GFRα1 Improves Cord Blood-Derived HSC in Vitro expansion and In Vivo engraftment Blood. 134: 1924-1924. DOI: 10.1182/Blood-2019-121331 |
0.31 |
|
| 2018 |
Yan W, Lakkaniga NR, Carlomangno F, Santoro M, McDonald N, Lv F, Gunaganti N, Frett B, Li HY. Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application. Journal of Medicinal Chemistry. PMID 30188734 DOI: 10.1021/Acs.Jmedchem.8B01092 |
0.34 |
|
| 2018 |
Nakaoku T, Kohno T, Araki M, Niho S, Chauhan R, Knowles PP, Tsuchihara K, Matsumoto S, Shimada Y, Mimaki S, Ishii G, Ichikawa H, Nagatoishi S, Tsumoto K, Okuno Y, ... ... McDonald NQ, et al. A secondary RET mutation in the activation loop conferring resistance to vandetanib. Nature Communications. 9: 625. PMID 29434222 DOI: 10.1038/S41467-018-02994-7 |
0.371 |
|
| 2018 |
Nakaoku T, Kohno T, Araki M, Nino S, Chauhan R, Knowles PP, Tsuchihara K, Matsumoto S, Shimada Y, Mimaki S, Ishii G, Ichikawa H, Okuno Y, Yoh K, McDonald NQ, et al. Abstract 918: A secondary RET mutation allosterically conferring resistance to vandetanib Cancer Research. 78: 918-918. DOI: 10.1158/1538-7445.Am2018-918 |
0.351 |
|
| 2017 |
Plenker D, Riedel M, Brägelmann J, Dammert MA, Chauhan R, Knowles PP, Lorenz C, Keul M, Bührmann M, Pagel O, Tischler V, Scheel AH, Schütte D, Song Y, Stark J, ... ... McDonald NQ, et al. Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors. Science Translational Medicine. 9. PMID 28615362 DOI: 10.1126/Scitranslmed.Aah6144 |
0.327 |
|
| 2016 |
Plaza-Menacho I, Barnouin K, Barry R, Borg A, Orme M, Chauhan R, Mouilleron S, Martínez-Torres RJ, Meier P, McDonald NQ. RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements. Cell Reports. 17: 3319-3332. PMID 28009299 DOI: 10.1016/J.Celrep.2016.11.061 |
0.418 |
|
| 2016 |
Soriano EV, Ivanova ME, Fletcher G, Riou P, Knowles PP, Barnouin K, Purkiss A, Kostelecky B, Saiu P, Linch M, Elbediwy A, Kjær S, O'Reilly N, Snijders AP, Parker PJ, ... ... McDonald NQ, et al. aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization. Developmental Cell. 38: 384-98. PMID 27554858 DOI: 10.1016/J.Devcel.2016.07.018 |
0.356 |
|
| 2016 |
Gabreski NA, Vaghasia JK, Novakova SS, McDonald NQ, Pierchala BA. Exon Skipping in RET Encodes Novel Isoforms that Differentially Regulate RET Signal Transduction. The Journal of Biological Chemistry. PMID 27226544 DOI: 10.1074/Jbc.M115.709675 |
0.378 |
|
| 2016 |
Newton R, Bowler KA, Burns EM, Chapman PJ, Fairweather EE, Fritzl SJ, Goldberg KM, Hamilton NM, Holt SV, Hopkins GV, Jones SD, Jordan AM, Lyons AJ, Nikki March H, McDonald NQ, et al. The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity. European Journal of Medicinal Chemistry. 112: 20-32. PMID 26874741 DOI: 10.1016/J.Ejmech.2016.01.039 |
0.338 |
|
| 2015 |
Ivanova ME, Fletcher GC, O'Reilly N, Purkiss AG, Thompson BJ, McDonald NQ. Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove. Acta Crystallographica. Section D, Biological Crystallography. 71: 555-64. PMID 25760605 DOI: 10.1107/S139900471402776X |
0.372 |
|
| 2015 |
roffey j, Turnbull A, Dillon C, Boyd S, Riou P, Linch M, Parker P, Kjaer S, McDonald N. Abstract LB-052: Kinase identification of proximal substrates (KIPS): A novel chemical genetics approach for kinase substrate identification Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-052 |
0.397 |
|
| 2014 |
Goodman KM, Kjær S, Beuron F, Knowles PP, Nawrotek A, Burns EM, Purkiss AG, George R, Santoro M, Morris EP, McDonald NQ. RET recognition of GDNF-GFRα1 ligand by a composite binding site promotes membrane-proximal self-association. Cell Reports. 8: 1894-904. PMID 25242331 DOI: 10.1016/J.Celrep.2014.08.040 |
0.336 |
|
| 2014 |
Plaza-Menacho I, Barnouin K, Goodman K, Martínez-Torres RJ, Borg A, Murray-Rust J, Mouilleron S, Knowles P, McDonald NQ. Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans. Molecular Cell. 53: 738-51. PMID 24560924 DOI: 10.1016/J.Molcel.2014.01.015 |
0.398 |
|
| 2014 |
Linch M, Riou P, Claus J, Cameron AJ, de Naurois J, Larijani B, Ng T, McDonald NQ, Parker PJ. Functional implications of assigned, assumed and assembled PKC structures. Biochemical Society Transactions. 42: 35-41. PMID 24450624 DOI: 10.1042/Bst20130192 |
0.391 |
|
| 2014 |
Soudy C, Stanway E, Patel B, Barton C, Barnard M, Pang L, Owen P, Turnbull A, Ruggeri BA, Dorsey BD, Ator MA, Ott GR, Linch M, Riou P, Parker PJ, ... ... McDonald NQ, et al. Abstract LB-99: Identification and characterization of small molecule thieno[3,2-d]pyrimidine inhibitors of Protein Kinase C iota (PKCι) Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-99 |
0.363 |
|
| 2014 |
Burns E, Goodman K, Kjaer S, Beuron F, Purkiss A, Nawrotek A, Knowles P, George R, Borg A, Nambozo SK, Mouilleron S, Morris E, McDonald N. Understanding RET receptor tyrosine kinase ligand recognition and chemical inhibition Acta Crystallographica Section A. 70. DOI: 10.1107/S205327331409559X |
0.342 |
|
| 2014 |
Plaza-Menacho I, Mologni L, McDonald NQ. Mechanisms of RET signaling in cancer: Current and future implications for targeted therapy Cellular Signalling. 26: 1743-1752. DOI: 10.1016/J.Cellsig.2014.03.032 |
0.305 |
|
| 2013 |
Linch M, Sanz-Garcia M, Soriano E, Zhang Y, Riou P, Rosse C, Cameron A, Knowles P, Purkiss A, Kjaer S, McDonald NQ, Parker PJ. A cancer-associated mutation in atypical protein kinase Cι occurs in a substrate-specific recruitment motif. Science Signaling. 6: ra82. PMID 24045153 DOI: 10.1126/Scisignal.2004068 |
0.377 |
|
| 2013 |
Fadden AJ, Schalbetter S, Bowles M, Harris R, Lally J, Carr AM, McDonald NQ. A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes. Nucleic Acids Research. 41: 9741-52. PMID 23982516 DOI: 10.1093/Nar/Gkt760 |
0.354 |
|
| 2013 |
Coulthard R, Deans AJ, Swuec P, Bowles M, Costa A, West SC, McDonald NQ. Architecture and DNA recognition elements of the Fanconi anemia FANCM-FAAP24 complex. Structure (London, England : 1993). 21: 1648-58. PMID 23932590 DOI: 10.1016/J.Str.2013.07.006 |
0.318 |
|
| 2013 |
Riou P, Kjær S, Garg R, Purkiss A, George R, Cain RJ, Bineva G, Reymond N, McColl B, Thompson AJ, O'Reilly N, McDonald NQ, Parker PJ, Ridley AJ. 14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins. Cell. 153: 640-53. PMID 23622247 DOI: 10.1016/J.Cell.2013.03.044 |
0.379 |
|
| 2013 |
Kjær S, Linch M, Purkiss A, Kostelecky B, Knowles PP, Rosse C, Riou P, Soudy C, Kaye S, Patel B, Soriano E, Murray-Rust J, Barton C, Dillon C, Roffey J, ... ... McDonald NQ, et al. Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. The Biochemical Journal. 451: 329-42. PMID 23418854 DOI: 10.1042/Bj20121871 |
0.401 |
|
| 2013 |
Linch M, Sanz-Garcia M, Kjaer S, Soriano E, Riou P, Knowles P, Dillon C, Roffey J, McDonald N, Parker P. Abstract A280: Small molecule inhibition of atypical protein kinase C iota reveals a functional basis for oncogenesis. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-A280 |
0.37 |
|
| 2013 |
Parker PJ, Linch M, McDonald NQ, VanHook AM. Science Signaling Podcast: 17 September 2013 Science Signaling. 6. DOI: 10.1126/Scisignal.2004685 |
0.311 |
|
| 2012 |
Mouilleron S, Wiezlak M, O'Reilly N, Treisman R, McDonald NQ. Structures of the Phactr1 RPEL domain and RPEL motif complexes with G-actin reveal the molecular basis for actin binding cooperativity. Structure (London, England : 1993). 20: 1960-70. PMID 23041370 DOI: 10.1016/J.Str.2012.08.031 |
0.35 |
|
| 2012 |
Wiezlak M, Diring J, Abella J, Mouilleron S, Way M, McDonald NQ, Treisman R. G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly. Journal of Cell Science. 125: 5860-72. PMID 22976292 DOI: 10.1242/Jcs.112078 |
0.34 |
|
| 2012 |
Bowles M, Lally J, Fadden AJ, Mouilleron S, Hammonds T, McDonald NQ. Fluorescence-based incision assay for human XPF-ERCC1 activity identifies important elements of DNA junction recognition. Nucleic Acids Research. 40: e101. PMID 22457069 DOI: 10.1093/Nar/Gks284 |
0.348 |
|
| 2011 |
Mouilleron S, Langer CA, Guettler S, McDonald NQ, Treisman R. Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator. Science Signaling. 4: ra40. PMID 21673315 DOI: 10.1126/Scisignal.2001750 |
0.317 |
|
| 2011 |
Plaza-Menacho I, Morandi A, Mologni L, Boender P, Gambacorti-Passerini C, Magee AI, Hofstra RM, Knowles P, McDonald NQ, Isacke CM. Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism. The Journal of Biological Chemistry. 286: 17292-302. PMID 21454698 DOI: 10.1074/Jbc.M110.168500 |
0.399 |
|
| 2011 |
Boëda B, Knowles PP, Briggs DC, Murray-Rust J, Soriano E, Garvalov BK, McDonald NQ, Way M. Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. The Journal of Biological Chemistry. 286: 11543-54. PMID 21278383 DOI: 10.1074/Jbc.M110.171264 |
0.376 |
|
| 2010 |
Kjaer S, Hanrahan S, Totty N, McDonald NQ. Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations. Nature Structural & Molecular Biology. 17: 726-31. PMID 20473317 DOI: 10.1038/Nsmb.1808 |
0.312 |
|
| 2010 |
Mologni L, Rostagno R, Brussolo S, Knowles PP, Kjaer S, Murray-Rust J, Rosso E, Zambon A, Scapozza L, McDonald NQ, Lucchini V, Gambacorti-Passerini C. Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors. Bioorganic & Medicinal Chemistry. 18: 1482-96. PMID 20117004 DOI: 10.1016/J.Bmc.2010.01.011 |
0.38 |
|
| 2009 |
Kostelecky B, Saurin AT, Purkiss A, Parker PJ, McDonald NQ. Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon. Embo Reports. 10: 983-9. PMID 19662078 DOI: 10.1038/Embor.2009.150 |
0.343 |
|
| 2009 |
Roffey J, Rosse C, Linch M, Hibbert A, McDonald NQ, Parker PJ. Protein kinase C intervention: the state of play. Current Opinion in Cell Biology. 21: 268-79. PMID 19233632 DOI: 10.1016/J.Ceb.2009.01.019 |
0.356 |
|
| 2009 |
Carlomagno F, Guida T, Anaganti S, Provitera L, Kjaer S, McDonald NQ, Ryan AJ, Santoro M. Identification of tyrosine 806 as a molecular determinant of RET kinase sensitivity to ZD6474. Endocrine-Related Cancer. 16: 233-41. PMID 19029224 DOI: 10.1677/Erc-08-0213 |
0.353 |
|
| 2008 |
Mouilleron S, Guettler S, Langer CA, Treisman R, McDonald NQ. Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL. The Embo Journal. 27: 3198-208. PMID 19008859 DOI: 10.1038/Emboj.2008.235 |
0.333 |
|
| 2008 |
Ciccia A, McDonald N, West SC. Structural and functional relationships of the XPF/MUS81 family of proteins. Annual Review of Biochemistry. 77: 259-87. PMID 18518821 DOI: 10.1146/Annurev.Biochem.77.070306.102408 |
0.341 |
|
| 2008 |
Kirk R, Laman H, Knowles PP, Murray-Rust J, Lomonosov M, Meziane el K, McDonald NQ. Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor. The Journal of Biological Chemistry. 283: 22325-35. PMID 18495667 DOI: 10.1074/Jbc.M709900200 |
0.39 |
|
| 2007 |
Boëda B, Briggs DC, Higgins T, Garvalov BK, Fadden AJ, McDonald NQ, Way M. Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding. Molecular Cell. 28: 1071-82. PMID 18158903 DOI: 10.1016/J.Molcel.2007.10.033 |
0.374 |
|
| 2007 |
Cameron AJ, De Rycker M, Calleja V, Alcor D, Kjaer S, Kostelecky B, Saurin A, Faisal A, Laguerre M, Hemmings BA, McDonald N, Larijani B, Parker PJ. Protein kinases, from B to C. Biochemical Society Transactions. 35: 1013-7. PMID 17956266 DOI: 10.1042/Bst0351013 |
0.374 |
|
| 2007 |
Plun-Favreau H, Klupsch K, Moisoi N, Gandhi S, Kjaer S, Frith D, Harvey K, Deas E, Harvey RJ, McDonald N, Wood NW, Martins LM, Downward J. The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nature Cell Biology. 9: 1243-52. PMID 17906618 DOI: 10.1038/Ncb1644 |
0.304 |
|
| 2007 |
Fox GC, Shafiq M, Briggs DC, Knowles PP, Collister M, Didmon MJ, Makrantoni V, Dickinson RJ, Hanrahan S, Totty N, Stark MJ, Keyse SM, McDonald NQ. Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases. Nature. 447: 487-92. PMID 17495930 DOI: 10.1038/Nature05804 |
0.336 |
|
| 2006 |
Rosivatz E, Matthews JG, McDonald NQ, Mulet X, Ho KK, Lossi N, Schmid AC, Mirabelli M, Pomeranz KM, Erneux C, Lam EWF, Vilar R, Woscholski R. A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). Acs Chemical Biology. 1: 780-790. PMID 17240976 DOI: 10.1021/Cb600352F |
0.345 |
|
| 2006 |
Knowles PP, Murray-Rust J, Kjaer S, Scott RP, Hanrahan S, Santoro M, Ibáñez CF, McDonald NQ. Structure and chemical inhibition of the RET tyrosine kinase domain. The Journal of Biological Chemistry. 281: 33577-87. PMID 16928683 DOI: 10.1074/Jbc.M605604200 |
0.44 |
|
| 2005 |
Laman H, Funes JM, Ye H, Henderson S, Galinanes-Garcia L, Hara E, Knowles P, McDonald N, Boshoff C. Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6 The Embo Journal. 24: 3104-3116. PMID 16096642 DOI: 10.1038/Sj.Emboj.7600775 |
0.306 |
|
| 2005 |
Nicastro G, Menon RP, Masino L, Knowles PP, McDonald NQ, Pastore A. The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition. Proceedings of the National Academy of Sciences of the United States of America. 102: 10493-8. PMID 16020535 DOI: 10.1073/Pnas.0501732102 |
0.364 |
|
| 2005 |
Newman M, Murray-Rust J, Lally J, Rudolf J, Fadden A, Knowles PP, White MF, McDonald NQ. Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition. The Embo Journal. 24: 895-905. PMID 15719018 DOI: 10.1038/Sj.Emboj.7600581 |
0.324 |
|
| 2004 |
Morgan CP, Skippen A, Segui B, Ball A, Allen-Baume V, Larijani B, Murray-Rust J, McDonald N, Sapkota G, Morrice N, Cockcroft S. Phosphorylation of a distinct structural form of phosphatidylinositol transfer protein alpha at Ser166 by protein kinase C disrupts receptor-mediated phospholipase C signaling by inhibiting delivery of phosphatidylinositol to membranes. The Journal of Biological Chemistry. 279: 47159-71. PMID 15322105 DOI: 10.1074/Jbc.M405827200 |
0.399 |
|
| 2004 |
Lehmann A, Katayama S, Harrison C, Dhut S, Kitamura K, McDonald N, Toda T. Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 9: 367-82. PMID 15147268 DOI: 10.1111/J.1356-9597.2004.00730.X |
0.334 |
|
| 2004 |
Tilley SJ, Skippen A, Murray-Rust J, Swigart PM, Stewart A, Morgan CP, Cockcroft S, McDonald NQ. Structure-function analysis of human [corrected] phosphatidylinositol transfer protein alpha bound to phosphatidylinositol. Structure (London, England : 1993). 12: 317-26. PMID 14962392 DOI: 10.1016/J.Str.2004.01.013 |
0.372 |
|
| 2002 |
Leiper J, Murray-Rust J, McDonald N, Vallance P. S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: Further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase Proceedings of the National Academy of Sciences of the United States of America. 99: 13527-13532. PMID 12370443 DOI: 10.1073/Pnas.212269799 |
0.318 |
|
| 2002 |
Hornig NC, Knowles PP, McDonald NQ, Uhlmann F. The dual mechanism of separase regulation by securin. Current Biology : Cb. 12: 973-82. PMID 12123570 DOI: 10.1016/S0960-9822(02)00847-3 |
0.345 |
|
| 2002 |
Norman RA, McAlister MS, Murray-Rust J, Movahedzadeh F, Stoker NG, McDonald NQ. Crystal structure of inositol 1-phosphate synthase from Mycobacterium tuberculosis, a key enzyme in phosphatidylinositol synthesis. Structure (London, England : 1993). 10: 393-402. PMID 12005437 DOI: 10.1016/S0969-2126(02)00718-9 |
0.316 |
|
| 2001 |
Murray-Rust J, Leiper J, McAlister M, Phelan J, Tilley S, Maria JS, Vallance P, McDonald N. Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase Nature Structural Biology. 8: 679-683. PMID 11473257 DOI: 10.1038/90387 |
0.329 |
|
| 2001 |
De Wilde G, Murray-Rust J, Boone E, Olerenshaw D, McDonald NQ, Ibanez C, Haegeman G, Wollmer A, Federwisch M. Structure-activity relationship of the p55 TNF receptor death domain and its lymphoproliferation mutants. European Journal of Biochemistry / Febs. 268: 1382-91. PMID 11231290 DOI: 10.1046/J.1432-1327.2001.02004.X |
0.373 |
|
| 2001 |
Card GL, Knowles P, Laman H, Jones N, Zhang W, Laue E, McDonald NQ. Structural biology of gamma-herpesvirus cyclins and how they subvert cyclin-dependent kinase inhibitor function Biochemical Society Transactions. 29. DOI: 10.1042/Bst029A047C |
0.356 |
|
| 2000 |
Berglund H, Olerenshaw D, Sankar A, Federwisch M, McDonald NQ, Driscoll PC. The three-dimensional solution structure and dynamic properties of the human FADD death domain Journal of Molecular Biology. 302: 171-188. PMID 10964568 DOI: 10.1006/Jmbi.2000.4011 |
0.349 |
|
| 2000 |
Card GL, Knowles P, Laman H, Jones N, McDonald NQ. Crystal structure of a gamma-herpesvirus cyclin-cdk complex. The Embo Journal. 19: 2877-88. PMID 10856233 DOI: 10.1093/Emboj/19.12.2877 |
0.379 |
|
| 2000 |
Hughes WE, Woscholski R, Cooke FT, Patrick RS, Dove SK, McDonald NQ, Parker PJ. SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases Journal of Biological Chemistry. 275: 801-808. PMID 10625610 DOI: 10.1074/Jbc.275.2.801 |
0.329 |
|
| 1999 |
Ruas M, Brookes S, McDonald NQ, Peters G. Functional evaluation of tumour-specific variants of p16(INK4a)/CDKN2A: Correlation with protein structure information Oncogene. 18: 5423-5434. PMID 10498896 DOI: 10.1038/Sj.Onc.1202918 |
0.332 |
|
| 1999 |
Swanton C, Card GL, Mann D, McDonald N, Jones N. Overcoming inhibitions: subversion of CKI function by viral cyclins. Trends in Biochemical Sciences. 24: 116-20. PMID 10203759 DOI: 10.1016/S0968-0004(99)01354-7 |
0.318 |
|
| 1999 |
Stewart AE, Dowd S, Keyse SM, McDonald NQ. Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation Nature Structural Biology. 6: 174-181. PMID 10048930 DOI: 10.1038/5861 |
0.376 |
|
| 1998 |
Pappa H, Dekker LV, Parker PJ, Mcdonald NQ. Preliminary X-ray analysis of a C2-like domain from protein kinase C-δ Acta Crystallographica Section D: Biological Crystallography. 54: 693-696. PMID 9761878 DOI: 10.1107/S0907444997019732 |
0.355 |
|
| 1998 |
Pappa H, Murray-Rust J, Dekker LV, Parker PJ, McDonald NQ. Crystal structure of the C2 domain from protein kinase C-δ Structure. 6: 885-894. PMID 9687370 DOI: 10.1016/S0969-2126(98)00090-2 |
0.371 |
|
| 1998 |
McDonald NQ, Peters G. Ankyrin for clues about the function of p16(ink4a) Nature Structural Biology. 5: 85-88. PMID 9461066 DOI: 10.1038/Nsb0298-85 |
0.343 |
|
| 1997 |
Bax B, Blundell TL, Murray-Rust J, McDonald NQ. Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins. Structure (London, England : 1993). 5: 1275-85. PMID 9351801 DOI: 10.1016/S0969-2126(97)00280-3 |
0.471 |
|
| 1995 |
McDonald NQ, Panayotatos N, Hendrickson WA. Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing Embo Journal. 14: 2689-2699. PMID 7796798 DOI: 10.1002/J.1460-2075.1995.Tb07269.X |
0.343 |
|
| 1995 |
McDonald NQ, Murray-Rust J, Blundell TL. The first structure of a receptor tyrosine kinase domain: a further step in understanding the molecular basis of insulin action. Structure (London, England : 1993). 3: 1-6. PMID 7743124 DOI: 10.1016/S0969-2126(01)00129-0 |
0.479 |
|
| 1995 |
McDonald NQ, Chao MV. Structural determinants of neurotrophin action. The Journal of Biological Chemistry. 270: 19669-72. PMID 7649974 DOI: 10.1074/Jbc.270.34.19669 |
0.313 |
|
| 1994 |
Bradshaw RA, Murray-Rust J, Ibáñez CF, McDonald NQ, Lapatto R, Blundell TL. Nerve growth factor: structure/function relationships. Protein Science : a Publication of the Protein Society. 3: 1901-13. PMID 7703837 DOI: 10.1002/Pro.5560031102 |
0.508 |
|
| 1993 |
McDonald NQ, Hendrickson WA. A structural superfamily of growth factors containing a cystine knot motif Cell. 73: 421-424. PMID 8490958 DOI: 10.1016/0092-8674(93)90127-C |
0.345 |
|
| 1993 |
Bradshaw RA, Blundell TL, Lapatto R, McDonald NQ, Murray-Rust J. Nerve growth factor revisited. Trends in Biochemical Sciences. 18: 48-52. PMID 8488558 DOI: 10.1016/0968-0004(93)90052-O |
0.475 |
|
| 1993 |
Murray-Rust J, McDonald NQ, Blundell TL, Hosang M, Oefner C, Winkler F, Bradshaw RA. Topological similarities in TGF-beta 2, PDGF-BB and NGF define a superfamily of polypeptide growth factors. Structure (London, England : 1993). 1: 153-9. PMID 8069627 DOI: 10.1016/0969-2126(93)90029-G |
0.47 |
|
| 1991 |
McDonald NQ, Blundell TL. Crystallization and characterization of the high molecular weight form of nerve growth factor (7 S NGF). Journal of Molecular Biology. 219: 595-601. PMID 2056528 DOI: 10.1016/0022-2836(91)90655-P |
0.373 |
|
| 1991 |
McDonald NQ, Lapatto R, Murray-Rust J, Gunning J, Wlodawer A, Blundell TL. New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor. Nature. 354: 411-4. PMID 1956407 DOI: 10.1038/354411A0 |
0.516 |
|
| 1990 |
McDonald NQ, Lapatto R, Murray-Rust J, Blundell TL. X-ray crystallographic studies on murine nerve growth factor. Journal of Cell Science. Supplement. 13: 19-30. PMID 2084116 |
0.411 |
|
| 1989 |
Greenfield C, Hiles I, Waterfield M, Federwisch M, Wollmer A, Blundell T, McDonald N. Epidermal growth factor binding induces a conformational change in the external domain of its receptor. The Embo Journal. 8: 4115-4123. DOI: 10.1002/J.1460-2075.1989.Tb08596.X |
0.486 |
|
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