| Year |
Citation |
Score |
| 2023 |
Green CL, Trautman ME, Chaiyakul K, Jain R, Alam YH, Babygirija R, Pak HH, Sonsalla MM, Calubag MF, Yeh CY, Bleicher A, Novak G, Liu TT, Newman S, Ricke WA, ... ... Lamming DW, et al. Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice. Cell Metabolism. 35: 1976-1995.e6. PMID 37939658 DOI: 10.1016/j.cmet.2023.10.005 |
0.306 |
|
| 2022 |
Flores V, Spicer AB, Sonsalla M, Richardson NE, Yu D, Sheridan GE, Trautman ME, Babygirija R, Cheng EP, Rojas JM, Yang SE, Wakai MH, Hubbell R, Kasza I, Tomasiewicz JL, ... ... Lamming DW, et al. Regulation of metabolic health by dietary histidine in mice. The Journal of Physiology. PMID 36086823 DOI: 10.1113/JP283261 |
0.803 |
|
| 2022 |
Trautman ME, Richardson NE, Lamming DW. Protein restriction and branched-chain amino acid restriction promote geroprotective shifts in metabolism. Aging Cell. e13626. PMID 35526271 DOI: 10.1111/acel.13626 |
0.75 |
|
| 2022 |
Green CL, Pak HH, Richardson NE, Flores V, Yu D, Tomasiewicz JL, Dumas SN, Kredell K, Fan JW, Kirsh C, Chaiyakul K, Murphy ME, Babygirija R, Barrett-Wilt GA, Rabinowitz J, ... ... Lamming DW, et al. Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction. Cell Metabolism. 34: 209-226.e5. PMID 35108511 DOI: 10.1016/j.cmet.2021.12.018 |
0.791 |
|
| 2021 |
Pak HH, Haws SA, Green CL, Koller M, Lavarias MT, Richardson NE, Yang SE, Dumas SN, Sonsalla M, Bray L, Johnson M, Barnes S, Darley-Usmar V, Zhang J, Yen CE, ... ... Lamming DW, et al. Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice. Nature Metabolism. PMID 34663973 DOI: 10.1038/s42255-021-00466-9 |
0.751 |
|
| 2021 |
Green CL, Lamming DW, Fontana L. Molecular mechanisms of dietary restriction promoting health and longevity. Nature Reviews. Molecular Cell Biology. PMID 34518687 DOI: 10.1038/s41580-021-00411-4 |
0.329 |
|
| 2021 |
Yu D, Richardson NE, Green CL, Spicer AB, Murphy ME, Flores V, Jang C, Kasza I, Nikodemova M, Wakai MH, Tomasiewicz JL, Yang SE, Miller BR, Pak HH, Brinkman JA, ... ... Lamming DW, et al. The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine. Cell Metabolism. PMID 33887198 DOI: 10.1016/j.cmet.2021.03.025 |
0.805 |
|
| 2021 |
Richardson NE, Konon EN, Schuster HS, Mitchell AT, Boyle C, Rodgers AC, Finke M, Haider LR, Yu D, Flores V, Pak HH, Ahmad S, Ahmed S, Radcliff A, Wu J, ... ... Lamming DW, et al. Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and lifespan in mice. Nature Aging. 1: 73-86. PMID 33796866 DOI: 10.1038/s43587-020-00006-2 |
0.8 |
|
| 2021 |
Kasza I, Kühn JP, Völzke H, Hernando D, Xu YG, Siebert JW, Gibson AL, Yen CE, Nelson DW, MacDougald OA, Richardson NE, Lamming DW, Kern PA, Alexander CM. Contrasting recruitment of skin-associated adipose depots during cold challenge of mouse and human. The Journal of Physiology. PMID 33724479 DOI: 10.1113/JP280922 |
0.706 |
|
| 2021 |
Schaid MD, Zhu Y, Richardson NE, Patibandla C, Ong IM, Fenske RJ, Neuman JC, Guthery E, Reuter A, Sandhu HK, Fuller MH, Cox ED, Davis DB, Layden BT, Brasier AR, ... Lamming DW, et al. Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin E Production and Signaling Mechanisms That Predict β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes. Metabolites. 11. PMID 33467110 DOI: 10.3390/metabo11010058 |
0.716 |
|
| 2020 |
Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, ... ... Lamming DW, et al. ARDD 2020: from aging mechanisms to interventions. Aging. 12. PMID 33378272 DOI: 10.18632/aging.202454 |
0.451 |
|
| 2020 |
Arriola Apelo SI, Lin A, Brinkman JA, Meyer E, Morrison M, Tomasiewicz JL, Pumper CP, Baar EL, Richardson NE, Alotaibi M, Lamming DW. Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging. Elife. 9. PMID 32720643 DOI: 10.7554/Elife.56177 |
0.762 |
|
| 2020 |
Ye L, Widlund AL, Sims CA, Lamming DW, Guan Y, Davis JG, Sabatini DM, Harrison DE, Vang O, Baur JA. Correction for: Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance. Aging. PMID 32268298 DOI: 10.18632/aging.102976 |
0.408 |
|
| 2020 |
Haws SA, Yu D, Ye C, Wille CK, Nguyen LC, Krautkramer KA, Tomasiewicz JL, Yang SE, Miller BR, Liu WH, Igarashi K, Sridharan R, Tu BP, Cryns VL, Lamming DW, et al. Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence. Molecular Cell. PMID 32208170 DOI: 10.1016/J.Molcel.2020.03.004 |
0.702 |
|
| 2020 |
Li Z, Votava JA, Zajac GJM, Nguyen JN, Leyva Jaimes FB, Ly SM, Brinkman JA, De Giorgi M, Kaul S, Green CL, St Clair SL, Belisle SL, Rios JM, Nelson DW, Sorci-Thomas MG, ... ... Lamming DW, et al. Integrating Mouse and Human Genetic Data to Move beyond GWAS and Identify Causal Genes in Cholesterol Metabolism. Cell Metabolism. PMID 32197071 DOI: 10.1016/J.Cmet.2020.02.015 |
0.31 |
|
| 2020 |
Bellantuono I, de Cabo R, Ehninger D, Di Germanio C, Lawrie A, Miller J, Mitchell SJ, Navas-Enamorado I, Potter PK, Tchkonia T, Trejo JL, Lamming DW. A toolbox for the longitudinal assessment of healthspan in aging mice. Nature Protocols. PMID 31915391 DOI: 10.1038/S41596-019-0256-1 |
0.434 |
|
| 2020 |
Carbajal K, Schaid M, Green C, Laundre E, Harrington J, Kelly G, Reuter A, Fenske R, Wehner M, Lamming D, Kimple M. Loss of β‐cell Gα
z
protects against high‐fat diet induced glucose intolerance by preserving incretin responsiveness and enhancing insulin secretion The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04098 |
0.309 |
|
| 2019 |
Yu D, Tomasiewicz JL, Yang SE, Miller BR, Wakai MH, Sherman DS, Cummings NE, Baar EL, Brinkman JA, Syed FA, Lamming DW. Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension. Cell Reports. 29: 236-248.e3. PMID 31577953 DOI: 10.1016/J.Celrep.2019.08.084 |
0.726 |
|
| 2019 |
Chellappa K, Brinkman JA, Mukherjee S, Morrison M, Alotaibi MI, Carbajal KA, Alhadeff AL, Perron IJ, Yao R, Purdy CS, DeFelice DM, Wakai MH, Tomasiewicz J, Lin A, Meyer E, ... ... Lamming DW, et al. Hypothalamic mTORC2 is essential for metabolic health and longevity. Aging Cell. e13014. PMID 31373126 DOI: 10.1111/Acel.13014 |
0.553 |
|
| 2019 |
Schreiber KH, Arriola Apelo SI, Yu D, Brinkman JA, Velarde MC, Syed FA, Liao CY, Baar EL, Carbajal KA, Sherman DS, Ortiz D, Brunauer R, Yang SE, Tzannis ST, Kennedy BK, ... Lamming DW, et al. A novel rapamycin analog is highly selective for mTORC1 in vivo. Nature Communications. 10: 3194. PMID 31324799 DOI: 10.1038/S41467-019-11174-0 |
0.792 |
|
| 2019 |
Dumas SN, Lamming DW. Next generation strategies for geroprotection via mTORC1 inhibition. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 30794726 DOI: 10.1093/Gerona/Glz056 |
0.443 |
|
| 2019 |
Pak HH, Cummings NE, Green CL, Brinkman JA, Yu D, Tomasiewicz JL, Yang SE, Boyle C, Konon EN, Ong IM, Lamming DW. The Metabolic Response to a Low Amino Acid Diet is Independent of Diet-Induced Shifts in the Composition of the Gut Microbiome. Scientific Reports. 9: 67. PMID 30635612 DOI: 10.1038/S41598-018-37177-3 |
0.739 |
|
| 2019 |
Lamming DW. SEX AND TISSUE SPECIFIC ROLES OF MTORC2 IN HEALTHSPAN, METABOLISM, AND SURVIVAL Innovation in Aging. 3: S370-S370. DOI: 10.1093/geroni/igz038.1351 |
0.328 |
|
| 2018 |
De Leon ER, Brinkman JA, Fenske RJ, Gregg T, Schmidt BA, Sherman DS, Cummings NE, Peter DC, Kimple ME, Lamming DW, Merrins MJ. Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice. Scientific Reports. 8: 17814. PMID 30546031 DOI: 10.1038/S41598-018-36289-0 |
0.376 |
|
| 2018 |
Lamming DW, Bar-Peled L. Lysosome: The Metabolic Signaling Hub. Traffic (Copenhagen, Denmark). PMID 30306667 DOI: 10.1111/Tra.12617 |
0.467 |
|
| 2018 |
Peng Y, Shapiro SL, Banduseela VC, Dieterich IA, Hewitt KJ, Bresnick EH, Kong G, Zhang J, Schueler KL, Keller MP, Attie AD, Hacker TA, Sullivan R, Kielar-Grevstad E, Arriola Apelo SI, ... Lamming DW, et al. Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype. Aging Cell. e12820. PMID 30051577 DOI: 10.1111/Acel.12820 |
0.44 |
|
| 2018 |
Green CL, Lamming DW. Regulation of metabolic health by essential dietary amino acids. Mechanisms of Ageing and Development. PMID 30044947 DOI: 10.1016/J.Mad.2018.07.004 |
0.508 |
|
| 2018 |
Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, ... Lamming DW, et al. Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. PMID 29849139 DOI: 10.1038/S41586-018-0187-Y |
0.744 |
|
| 2018 |
Yu D, Yang SE, Miller BR, Wisinski JA, Sherman DS, Brinkman JA, Tomasiewicz JL, Cummings NE, Kimple ME, Cryns VL, Lamming DW. Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701211R. PMID 29401631 DOI: 10.1096/Fj.201701211R |
0.748 |
|
| 2017 |
Cummings NE, Williams EM, Kasza I, Konon EN, Schaid MD, Schmidt BA, Poudel C, Sherman DS, Yu D, Arriola Apelo SI, Cottrell SE, Geiger G, Barnes ME, Wisinski JA, Fenske RJ, ... ... Lamming DW, et al. Restoration of metabolic health by decreased consumption of branched-chain amino acids. The Journal of Physiology. PMID 29266268 DOI: 10.1113/Jp275075 |
0.74 |
|
| 2017 |
Knoll M, Winther S, Natarajan A, Yang H, Jiang M, Thiru P, Shahsafaei A, Chavarria TE, Lamming DW, Sun L, Hansen JB, Lodish HF. SYK kinase mediates brown fat differentiation and activation. Nature Communications. 8: 2115. PMID 29235464 DOI: 10.1038/S41467-017-02162-3 |
0.589 |
|
| 2017 |
Waqas SFH, Hoang AC, Lin YT, Ampem G, Azegrouz H, Balogh L, Thuróczy J, Chen JC, Gerling IC, Nam S, Lim JS, Martinez-Ibañez J, Real JT, Paschke S, Quillet R, ... ... Lamming DW, et al. Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages. The Journal of Clinical Investigation. PMID 28581443 DOI: 10.1172/Jci90152 |
0.442 |
|
| 2017 |
Arriola Apelo S, Pumper C, Cummings N, Lin A, Baar E, Lamming D. FEMALE SEX HORMONES ALTER THE METABOLIC IMPACT OF HEPATIC RICTOR DELETION Innovation in Aging. 1: 859-859. DOI: 10.1093/Geroni/Igx004.3091 |
0.312 |
|
| 2017 |
Cummings N, Radcliff A, Konon E, Hebda E, Arriola Apelo S, Barnes M, Wu J, Lamming D. DECREASED CONSUMPTION OF SPECIFIC MACRONUTRIENTS PROMOTES METABOLIC HEALTH AND LONGEVITY Innovation in Aging. 1: 856-857. DOI: 10.1093/Geroni/Igx004.3083 |
0.371 |
|
| 2016 |
Cummings NE, Lamming DW. Regulation of metabolic health and aging by nutrient-sensitive signaling pathways. Molecular and Cellular Endocrinology. PMID 27884780 DOI: 10.1016/J.Mce.2016.11.014 |
0.522 |
|
| 2016 |
Arriola Apelo SI, Lamming DW. mTORC2 Puts Its Shoulder to Krebs' Wheel. Molecular Cell. 63: 723-5. PMID 27588599 DOI: 10.1016/J.Molcel.2016.08.016 |
0.39 |
|
| 2016 |
Fontana L, Cummings NE, Arriola Apelo SI, Neuman JC, Kasza I, Schmidt BA, Cava E, Spelta F, Tosti V, Syed FA, Baar EL, Veronese N, Cottrell SE, Fenske RJ, Bertozzi B, ... ... Lamming DW, et al. Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health. Cell Reports. PMID 27346343 DOI: 10.1016/J.Celrep.2016.05.092 |
0.514 |
|
| 2016 |
Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Marinez PA, McCord JM, Miller BF, et al. Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer. Aging Cell. PMID 27312235 DOI: 10.1111/Acel.12496 |
0.529 |
|
| 2016 |
Kennedy BK, Lamming DW. The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging. Cell Metabolism. 23: 990-1003. PMID 27304501 DOI: 10.1016/J.Cmet.2016.05.009 |
0.508 |
|
| 2016 |
Gregg T, Poudel C, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW, Merrins MJ. Pancreatic β cells from Mice Offset Age-Associated Mitochondrial Deficiency with Reduced KATP Channel Activity. Diabetes. PMID 27284112 DOI: 10.2337/Db16-0432 |
0.458 |
|
| 2016 |
Arriola Apelo SI, Lamming DW. Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 27208895 DOI: 10.1093/Gerona/Glw090 |
0.45 |
|
| 2016 |
Arriola Apelo SI, Pumper CP, Baar EL, Cummings NE, Lamming DW. Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 27091134 DOI: 10.1093/Gerona/Glw064 |
0.488 |
|
| 2016 |
Lamming DW. Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond. Cold Spring Harbor Perspectives in Medicine. PMID 27048303 DOI: 10.1101/Cshperspect.A025924 |
0.465 |
|
| 2016 |
Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, ... Lamming DW, et al. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 531: 53-8. PMID 26935695 DOI: 10.1038/Nature17173 |
0.77 |
|
| 2016 |
Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Polynne-Stapornkul T, Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, et al. Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation. Elife. 5. PMID 26894960 DOI: 10.7554/Elife.11612 |
0.462 |
|
| 2016 |
Tran CM, Mukherjee S, Ye L, Frederick DW, Kissig M, Davis JG, Lamming DW, Seale P, Baur JA. Rapamycin blocks induction of the thermogenic program in white adipose tissue. Diabetes. PMID 26858361 DOI: 10.2337/Db15-0502 |
0.474 |
|
| 2016 |
Baar EL, Carbajal KA, Ong IM, Lamming DW. Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice. Aging Cell. 15: 155-66. PMID 26695882 DOI: 10.1111/Acel.12425 |
0.461 |
|
| 2016 |
Arriola Apelo SI, Neuman JC, Baar EL, Syed FA, Cummings NE, Brar HK, Pumper CP, Kimple ME, Lamming DW. Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system. Aging Cell. 15: 28-38. PMID 26463117 DOI: 10.1111/Acel.12405 |
0.47 |
|
| 2016 |
Apelo SA, Pumper C, Baar E, Cummings N, Brar H, Kimple M, Lamming D, Neuman J. Id: 21: Alternative Rapamycin Treatment Regimens Mitigate The Impact Of Rapamycin On Glucose Homeostasis And The Immune System, And Extends Lifespan Journal of Investigative Medicine. 64: 932-933. DOI: 10.1136/Jim-2016-000120.45 |
0.493 |
|
| 2016 |
Lamming D, Cummings N, Arriola Apelo S, Neuman J, Schmidt B, Merrins M, Kimple M, Fontana L. ID: 78: IMPROVING GLYCEMIC CONTROL THROUGH REDUCTION OF SPECIFIC DIETARY AMINO ACIDS Journal of Investigative Medicine. 64: 926.1-926. DOI: 10.1136/Jim-2016-000120.32 |
0.51 |
|
| 2015 |
Lamming DW, Cummings NE, Rastelli AL, Gao F, Cava E, Bertozzi B, Spelta F, Pili R, Fontana L. Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model. Oncotarget. PMID 26378060 DOI: 10.18632/Oncotarget.5180 |
0.453 |
|
| 2015 |
Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Polynne-Stapornkul T, Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, et al. Author response: Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation Elife. DOI: 10.7554/Elife.11612.024 |
0.445 |
|
| 2014 |
Lamming DW. Diminished mTOR signaling: a common mode of action for endocrine longevity factors. Springerplus. 3: 735. PMID 25674466 DOI: 10.1186/2193-1801-3-735 |
0.459 |
|
| 2014 |
Liu Y, Diaz V, Fernandez E, Strong R, Ye L, Baur JA, Lamming DW, Richardson A, Salmon AB. Rapamycin-induced metabolic defects are reversible in both lean and obese mice. Aging. 6: 742-54. PMID 25324470 |
0.32 |
|
| 2014 |
Lamming DW. mTORC2 takes the longevity stAGE. Oncotarget. 5: 7214-5. PMID 25294787 DOI: 10.18632/Oncotarget.2457 |
0.515 |
|
| 2014 |
Lamming DW, Mihaylova MM, Katajisto P, Baar EL, Yilmaz OH, Hutchins A, Gultekin Y, Gaither R, Sabatini DM. Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan. Aging Cell. 13: 911-7. PMID 25059582 DOI: 10.1111/Acel.12256 |
0.707 |
|
| 2014 |
Efeyan A, Schweitzer LD, Bilate AM, Chang S, Kirak O, Lamming DW, Sabatini DM. RagA, but not RagB, is essential for embryonic development and adult mice. Developmental Cell. 29: 321-9. PMID 24768164 DOI: 10.1016/J.Devcel.2014.03.017 |
0.616 |
|
| 2014 |
Soliman MA, Abdel Rahman AM, Lamming DW, Lamming DA, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T. The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism. Science Signaling. 7: ra17. PMID 24550542 DOI: 10.1126/Scisignal.2004785 |
0.758 |
|
| 2014 |
Lamming DW, Demirkan G, Boylan JM, Mihaylova MM, Peng T, Ferreira J, Neretti N, Salomon A, Sabatini DM, Gruppuso PA. Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2). Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 300-15. PMID 24072782 DOI: 10.1096/Fj.13-237743 |
0.633 |
|
| 2013 |
Byles V, Covarrubias AJ, Ben-Sahra I, Lamming DW, Sabatini DM, Manning BD, Horng T. The TSC-mTOR pathway regulates macrophage polarization. Nature Communications. 4: 2834. PMID 24280772 DOI: 10.1038/Ncomms3834 |
0.596 |
|
| 2013 |
Lamming DW, Sabatini DM. A Central role for mTOR in lipid homeostasis. Cell Metabolism. 18: 465-9. PMID 23973332 DOI: 10.1016/J.Cmet.2013.08.002 |
0.613 |
|
| 2013 |
Ye L, Widlund AL, Sims CA, Lamming DW, Guan Y, Davis JG, Sabatini DM, Harrison DE, Vang O, Baur JA. Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance. Aging. 5: 539-50. PMID 23929887 |
0.466 |
|
| 2013 |
Lamming DW, Ye L, Astle CM, Baur JA, Sabatini DM, Harrison DE. Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive. Aging Cell. 12: 712-8. PMID 23648089 DOI: 10.1111/Acel.12097 |
0.619 |
|
| 2013 |
Mercken EM, Crosby SD, Lamming DW, JeBailey L, Krzysik-Walker S, Villareal DT, Capri M, Franceschi C, Zhang Y, Becker K, Sabatini DM, de Cabo R, Fontana L. Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell. 12: 645-51. PMID 23601134 DOI: 10.1111/Acel.12088 |
0.621 |
|
| 2013 |
Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, et al. Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science (New York, N.Y.). 339: 1216-9. PMID 23471411 DOI: 10.1126/Science.1231097 |
0.767 |
|
| 2013 |
Lamming DW, Ye L, Sabatini DM, Baur JA. Rapalogs and mTOR inhibitors as anti-aging therapeutics. The Journal of Clinical Investigation. 123: 980-9. PMID 23454761 DOI: 10.1172/Jci64099 |
0.595 |
|
| 2012 |
Lamming DW, Sabatini DM, Baur JA. Pharmacologic Means of Extending Lifespan. Journal of Clinical & Experimental Pathology. PMID 25379357 DOI: 10.4172/2161-0681.S4-002 |
0.573 |
|
| 2012 |
Ye L, Varamini B, Lamming DW, Sabatini DM, Baur JA. Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2. Frontiers in Genetics. 3: 177. PMID 22973301 DOI: 10.3389/Fgene.2012.00177 |
0.534 |
|
| 2012 |
Yilmaz ÖH, Katajisto P, Lamming DW, Gültekin Y, Bauer-Rowe KE, Sengupta S, Birsoy K, Dursun A, Yilmaz VO, Selig M, Nielsen GP, Mino-Kenudson M, Zukerberg LR, Bhan AK, Deshpande V, et al. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature. 486: 490-5. PMID 22722868 DOI: 10.1038/Nature11163 |
0.693 |
|
| 2012 |
Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, Sabatini DM, Blackwell TK. TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metabolism. 15: 713-24. PMID 22560223 DOI: 10.1016/J.Cmet.2012.04.007 |
0.626 |
|
| 2012 |
Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science (New York, N.Y.). 335: 1638-43. PMID 22461615 DOI: 10.1126/Science.1215135 |
0.614 |
|
| 2011 |
Lamming DW, Sabatini DM. A radical role for TOR in longevity. Cell Metabolism. 13: 617-8. PMID 21641542 DOI: 10.1016/J.Cmet.2011.05.006 |
0.63 |
|
| 2010 |
Lamming DW, Sabatini DM. Regulation of TOR signaling in mammals Enzymes. 27: 21-38. DOI: 10.1016/S1874-6047(10)27002-6 |
0.615 |
|
| 2007 |
Medvedik O, Lamming DW, Kim KD, Sinclair DA. MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. Plos Biology. 5: e261. PMID 17914901 DOI: 10.1371/Journal.Pbio.0050261 |
0.78 |
|
| 2007 |
Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA. Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell. 130: 1095-107. PMID 17889652 DOI: 10.1016/J.Cell.2007.07.035 |
0.733 |
|
| 2006 |
Yu MC, Lamming DW, Eskin JA, Sinclair DA, Silver PA. The role of protein arginine methylation in the formation of silent chromatin. Genes & Development. 20: 3249-54. PMID 17158743 DOI: 10.1101/Gad.1495206 |
0.528 |
|
| 2006 |
Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C, Lin S, Sinclair DA. Response to Comment on "HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction" Science. 312: 1312-1312. DOI: 10.1126/Science.1124767 |
0.741 |
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| 2005 |
Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C, Lin SJ, Sinclair DA. HST2 mediates SIR2-independent life-span extension by calorie restriction. Science (New York, N.Y.). 309: 1861-4. PMID 16051752 DOI: 10.1126/Science.1113611 |
0.749 |
|
| 2004 |
Lamming DW, Wood JG, Sinclair DA. Small molecules that regulate lifespan: evidence for xenohormesis. Molecular Microbiology. 53: 1003-9. PMID 15306006 DOI: 10.1111/J.1365-2958.2004.04209.X |
0.572 |
|
| 2003 |
Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 425: 191-6. PMID 12939617 DOI: 10.1038/Nature01960 |
0.773 |
|
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