| Year |
Citation |
Score |
| 2023 |
Leus IV, Olvera M, Adamiak JW, Nguyen LL, Zgurskaya HI. Survival under Infection-Associated Stresses Depends on the Expression of Resistance-Nodulation-Division and Major Facilitator Superfamily Efflux Pumps. Antibiotics (Basel, Switzerland). 13. PMID 38275317 DOI: 10.3390/antibiotics13010007 |
0.445 |
|
| 2023 |
Leus IV, Roberts SR, Trinh A, W Yu E, Zgurskaya HI. Nonadditive functional interactions between ligand-binding sites of the multidrug efflux pump AdeB from . Journal of Bacteriology. e0021723. PMID 37850798 DOI: 10.1128/jb.00217-23 |
0.427 |
|
| 2023 |
Gervasoni S, Mehla J, Bergen CR, Leus IV, Margiotta E, Malloci G, Bosin A, Vargiu AV, Lomovskaya O, Rybenkov VV, Ruggerone P, Zgurskaya HI. Molecular determinants of avoidance and inhibition of MexB efflux pump. Mbio. e0140323. PMID 37493633 DOI: 10.1128/mbio.01403-23 |
0.333 |
|
| 2023 |
Russell Lewis B, Uddin MR, Moniruzzaman M, Kuo KM, Higgins AJ, Shah LMN, Sobott F, Parks JM, Hammerschmid D, Gumbart JC, Zgurskaya HI, Reading E. Conformational restriction shapes the inhibition of a multidrug efflux adaptor protein. Nature Communications. 14: 3900. PMID 37463890 DOI: 10.1038/s41467-023-39615-x |
0.402 |
|
| 2023 |
North EJ, Schwartz CP, Zgurskaya HI, Jackson M. Recent advances in mycobacterial membrane protein large 3 inhibitor drug design for mycobacterial infections. Expert Opinion On Drug Discovery. 18: 707-724. PMID 37226498 DOI: 10.1080/17460441.2023.2218082 |
0.319 |
|
| 2023 |
Cao F, Kinthada R, Boehm T, D' Cunha N, Leus IV, Orth C, Zgurskaya HI, Walker JK. Identification and structure-activity relationships for a series of N, N-disubstituted 2-aminobenzothiazoles as potent inhibitors of S. aureus. Bioorganic & Medicinal Chemistry Letters. 129301. PMID 37094726 DOI: 10.1016/j.bmcl.2023.129301 |
0.306 |
|
| 2023 |
Li Y, Acharya A, Yang L, Liu J, Tajkhorshid E, Zgurskaya HI, Jackson M, Gumbart JC. Insights into substrate transport and water permeation in the mycobacterial transporter MmpL3. Biophysical Journal. PMID 36926696 DOI: 10.1016/j.bpj.2023.03.018 |
0.489 |
|
| 2023 |
Leus IV, Adamiak J, Chandar B, Bonifay V, Zhao S, Walker SS, Squadroni B, Balibar CJ, Kinarivala N, Standke LC, Voss HU, Tan DS, Rybenkov VV, Zgurskaya HI. Functional Diversity of Gram-Negative Permeability Barriers Reflected in Antibacterial Activities and Intracellular Accumulation of Antibiotics. Antimicrobial Agents and Chemotherapy. e0137722. PMID 36715507 DOI: 10.1128/aac.01377-22 |
0.445 |
|
| 2023 |
Stampolaki M, Malwal SR, Alvarez-Cabrera N, Gao Z, Moniruzzaman M, Babii SO, Naziris N, Rey-Cibati A, Valladares-Delgado M, Turcu AL, Baek KH, Phan TN, Lee H, Alcaraz M, Watson S, ... ... Zgurskaya HI, et al. Synthesis and Testing of Analogs of the Tuberculosis Drug Candidate SQ109 against Bacteria and Protozoa: Identification of Lead Compounds against and Malaria Parasites. Acs Infectious Diseases. PMID 36706233 DOI: 10.1021/acsinfecdis.2c00537 |
0.394 |
|
| 2022 |
Manrique PD, López CA, Gnanakaran S, Rybenkov VV, Zgurskaya HI. New understanding of multidrug efflux and permeation in antibiotic resistance, persistence, and heteroresistance. Annals of the New York Academy of Sciences. PMID 36344198 DOI: 10.1111/nyas.14921 |
0.411 |
|
| 2022 |
Hu Z, Leus IV, Chandar B, Sherborne BS, Avila QP, Rybenkov VV, Zgurskaya HI, Duerfeldt AS. Structure-Uptake Relationship Studies of Oxazolidinones in Gram-Negative ESKAPE Pathogens. Journal of Medicinal Chemistry. 65: 14144-14179. PMID 36257060 DOI: 10.1021/acs.jmedchem.2c01349 |
0.391 |
|
| 2022 |
Zgurskaya HI, Adamiak JW, Leus IV. Making sense of drug-efflux transporters in the physiological environment. Current Opinion in Microbiology. 69: 102179. PMID 35882103 DOI: 10.1016/j.mib.2022.102179 |
0.49 |
|
| 2022 |
Stevens CM, Babii SO, Pandya AN, Li W, Li Y, Mehla J, Scott R, Hegde P, Prathipati PK, Acharya A, Liu J, Gumbart JC, North J, Jackson M, Zgurskaya HI. Proton transfer activity of the reconstituted MmpL3 is modulated by substrate mimics and inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 119: e2113963119. PMID 35858440 DOI: 10.1073/pnas.2113963119 |
0.492 |
|
| 2022 |
Gervasoni S, Malloci G, Bosin A, Vargiu AV, Zgurskaya HI, Ruggerone P. Recognition of quinolone antibiotics by the multidrug efflux transporter MexB of . Physical Chemistry Chemical Physics : Pccp. PMID 35766032 DOI: 10.1039/d2cp00951j |
0.334 |
|
| 2021 |
Gumbart JC, Ferreira JL, Hwang H, Hazel AJ, Cooper CJ, Parks JM, Smith JC, Zgurskaya HI, Beeby M. Lpp positions peptidoglycan at the AcrA-TolC interface in the AcrAB-TolC multidrug efflux pump. Biophysical Journal. PMID 34411576 DOI: 10.1016/j.bpj.2021.08.016 |
0.394 |
|
| 2021 |
D'Cunha N, Moniruzzaman M, Haynes K, Malloci G, Cooper CJ, Margiotta E, Vargiu AV, Uddin MR, Leus IV, Cao F, Parks JM, Rybenkov VV, Ruggerone P, Zgurskaya HI, Walker JK. Mechanistic Duality of Bacterial Efflux Substrates and Inhibitors: Example of Simple Substituted Cinnamoyl and Naphthyl Amides. Acs Infectious Diseases. PMID 34379382 DOI: 10.1021/acsinfecdis.1c00100 |
0.356 |
|
| 2021 |
Adamiak JW, Jhawar V, Bonifay V, Chandler CE, Leus IV, Ernst RK, Schweizer HP, Zgurskaya HI. Loss of RND-type multidrug efflux pumps triggers iron starvation and lipid A modifications in . Antimicrobial Agents and Chemotherapy. AAC0059221. PMID 34252310 DOI: 10.1128/AAC.00592-21 |
0.458 |
|
| 2021 |
Zgurskaya HI. Introduction: Transporters, Porins, and Efflux Pumps. Chemical Reviews. 121: 5095-5097. PMID 33975431 DOI: 10.1021/acs.chemrev.1c00010 |
0.364 |
|
| 2021 |
Zgurskaya HI, Malloci G, Chandar B, Vargiu AV, Ruggerone P. Bacterial efflux transporters' polyspecificity - a gift and a curse? Current Opinion in Microbiology. 61: 115-123. PMID 33940284 DOI: 10.1016/j.mib.2021.03.009 |
0.465 |
|
| 2021 |
Morgan CE, Glaza P, Leus IV, Trinh A, Su CC, Cui M, Zgurskaya HI, Yu EW. Cryoelectron Microscopy Structures of AdeB Illuminate Mechanisms of Simultaneous Binding and Exporting of Substrates. Mbio. 12. PMID 33622726 DOI: 10.1128/mBio.03690-20 |
0.396 |
|
| 2021 |
Rybenkov VV, Zgurskaya HI, Ganguly C, Leus IV, Zhang Z, Moniruzzaman M. The Whole Is Bigger than the Sum of Its Parts: Drug Transport in the Context of Two Membranes with Active Efflux. Chemical Reviews. PMID 33596653 DOI: 10.1021/acs.chemrev.0c01137 |
0.527 |
|
| 2021 |
Zgurskaya HI, Walker JK, Parks JM, Rybenkov VV. Multidrug Efflux Pumps and the Two-Faced Janus of Substrates and Inhibitors. Accounts of Chemical Research. PMID 33539084 DOI: 10.1021/acs.accounts.0c00843 |
0.547 |
|
| 2021 |
Mehla J, Malloci G, Mansbach R, López CA, Tsivkovski R, Haynes K, Leus IV, Grindstaff SB, Cascella RH, D'Cunha N, Herndon L, Hengartner NW, Margiotta E, Atzori A, Vargiu AV, ... ... Zgurskaya HI, et al. Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa. Mbio. 12. PMID 33468691 DOI: 10.1128/mBio.02785-20 |
0.361 |
|
| 2020 |
Zhao S, Adamiak JW, Bonifay V, Mehla J, Zgurskaya HI, Tan DS. Defining new chemical space for drug penetration into Gram-negative bacteria. Nature Chemical Biology. 16: 1293-1302. PMID 33199906 DOI: 10.1038/s41589-020-00674-6 |
0.302 |
|
| 2020 |
Jackson M, Stevens CM, Zhang L, Zgurskaya HI, Niederweis M. Transporters Involved in the Biogenesis and Functionalization of the Mycobacterial Cell Envelope. Chemical Reviews. PMID 33170669 DOI: 10.1021/acs.chemrev.0c00869 |
0.392 |
|
| 2020 |
Fabre L, Ntreh AT, Yazidi A, Leus IV, Weeks JW, Bhattacharyya S, Ruickoldt J, Rouiller I, Zgurskaya HI, Sygusch J. A "Drug Sweeping" State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa. Structure (London, England : 1993). PMID 32966762 DOI: 10.1016/j.str.2020.09.001 |
0.475 |
|
| 2020 |
Leus IV, Adamiak J, Trinh AN, Smith RD, Smith L, Richardson S, Ernst RK, Zgurskaya HI. Inactivation of AdeABC and AdeIJK efflux pumps elicits specific nonoverlapping transcriptional and phenotypic responses in Acinetobacter baumannii. Molecular Microbiology. PMID 32858760 DOI: 10.1111/Mmi.14594 |
0.42 |
|
| 2020 |
Mansbach RA, Leus IV, Mehla J, Lopez CA, Walker JK, Rybenkov VV, Hengartner N, Zgurskaya HI, Gnanakaran S. Machine Learning Algorithm Identifies an Antibiotic Vocabulary for Permeating Gram-Negative Bacteria. Journal of Chemical Information and Modeling. PMID 32453589 DOI: 10.1021/Acs.Jcim.0C00352 |
0.313 |
|
| 2020 |
Saha P, Sikdar S, Krishnamoorthy G, Zgurskaya HI, Rybenkov VV. Drug permeation against efflux by two transporters. Acs Infectious Diseases. PMID 32039579 DOI: 10.1021/Acsinfecdis.9B00510 |
0.718 |
|
| 2020 |
Green AT, Moniruzzaman M, Cooper CJ, Walker JK, Smith JC, Parks JM, Zgurskaya HI. Discovery of multidrug efflux pump inhibitors with a novel chemical scaffold. Biochimica Et Biophysica Acta. General Subjects. 129546. PMID 32032658 DOI: 10.1016/J.Bbagen.2020.129546 |
0.526 |
|
| 2020 |
Gumbart JC, Ferreira J, hwang S, Hazel A, Parks JM, Smith JC, Beeby M, Zgurskaya H. Modeling the Placement of the AcrAB-TolC Multidrug Efflux Pump in the Bacterial Cell Envelope Biophysical Journal. 118: 13a. DOI: 10.1016/J.Bpj.2019.11.251 |
0.416 |
|
| 2019 |
López CA, Zgurskaya H, Gnanakaran S. Molecular characterization of the outer membrane of Pseudomonas aeruginosa. Biochimica Et Biophysica Acta. Biomembranes. 183151. PMID 31846648 DOI: 10.1016/J.Bbamem.2019.183151 |
0.522 |
|
| 2019 |
Hazel A, Abdali N, Leus I, Parks JM, Smith JC, Zgurskaya HI, Gumbart JC. Conformational dynamics of AcrA govern multidrug efflux pump assembly. Acs Infectious Diseases. PMID 31517484 DOI: 10.1021/Acsinfecdis.9B00273 |
0.52 |
|
| 2019 |
Krishnamoorthy G, Weeks JW, Zhang Z, Chandler C, Xue H, Schweizer HP, Ernst RK, Zgurskaya HI. Efflux pumps of control the permeability barrier of the outer membrane. Antimicrobial Agents and Chemotherapy. PMID 31383661 DOI: 10.1128/Aac.00956-19 |
0.715 |
|
| 2019 |
Belardinelli JM, Stevens CM, Li W, Tan YZ, Jones V, Mancia F, Zgurskaya HI, Jackson M. The MmpL3 interactome reveals a complex crosstalk between cell envelope biosynthesis and cell elongation and division in mycobacteria. Scientific Reports. 9: 10728. PMID 31341202 DOI: 10.1038/S41598-019-47159-8 |
0.564 |
|
| 2019 |
Zgurskaya HI, Rybenkov VV. Permeability barriers of Gram-negative pathogens. Annals of the New York Academy of Sciences. PMID 31165502 DOI: 10.1111/Nyas.14134 |
0.519 |
|
| 2019 |
Li Y, Gardner JJ, Fortney KR, Leus IV, Bonifay V, Zgurskaya HI, Pletnev AA, Zhang S, Zhang ZY, Gribble GW, Spinola SM, Duerfeldt AS. First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 31104993 DOI: 10.1016/J.Bmcl.2019.05.003 |
0.372 |
|
| 2019 |
Li W, Stevens CM, Pandya AN, Darzynkiewicz Z, Bhattarai P, Tong W, Gonzales-Juarrero M, North EJ, Zgurskaya HI, Jackson MC. Direct inhibition of MmpL3 by novel antitubercular compounds. Acs Infectious Diseases. PMID 30882198 DOI: 10.1021/Acsinfecdis.9B00048 |
0.395 |
|
| 2019 |
Darzynkiewicz ZM, Green AT, Abdali N, Hazel A, Fulton RL, Kimball J, Gryczynski Z, Gumbart JC, Parks JM, Smith JC, Zgurskaya HI. Identification of Binding Sites for Efflux Pump Inhibitors of the AcrAB-TolC Component AcrA. Biophysical Journal. PMID 30691677 DOI: 10.1016/J.Bpj.2019.01.010 |
0.349 |
|
| 2018 |
Cooper SJ, Krishnamoorthy G, Wolloscheck D, Walker JK, Rybenkov VV, Parks JM, Zgurskaya HI. Molecular Properties that Define the Activities of Antibiotics in Escherichia coli and Pseudomonas aeruginosa. Acs Infectious Diseases. PMID 29756762 DOI: 10.1021/Acsinfecdis.8B00036 |
0.642 |
|
| 2018 |
Leus IV, Weeks JW, Bonifay V, Smith L, Richardson S, Zgurskaya HI. Substrate specificities and efflux efficiencies of RND efflux pumps of . Journal of Bacteriology. PMID 29661860 DOI: 10.1128/Jb.00049-18 |
0.52 |
|
| 2018 |
Zgurskaya HI, Rybenkov VV, Krishnamoorthy G, Leus IV. Trans-envelope multidrug efflux pumps of Gram-negative bacteria and their synergism with the outer membrane barrier. Research in Microbiology. PMID 29454787 DOI: 10.1016/J.Resmic.2018.02.002 |
0.69 |
|
| 2018 |
Picard M, Tikhonova EB, Broutin I, Lu S, Verchère A, Zgurskaya HI. Biochemical Reconstitution and Characterization of Multicomponent Drug Efflux Transporters. Methods in Molecular Biology (Clifton, N.J.). 1700: 113-145. PMID 29177829 DOI: 10.1007/978-1-4939-7454-2_8 |
0.761 |
|
| 2017 |
López CA, Travers T, Pos KM, Zgurskaya HI, Gnanakaran S. Dynamics of Intact MexAB-OprM Efflux Pump: Focusing on the MexA-OprM Interface. Scientific Reports. 7: 16521. PMID 29184094 DOI: 10.1038/S41598-017-16497-W |
0.549 |
|
| 2017 |
Yue Z, Chen W, Zgurskaya HI, Shen J. Constant pH Molecular Dynamics Reveals How Proton Release Drives the Conformational Transition of a Transmembrane Efflux Pump. Journal of Chemical Theory and Computation. PMID 29117682 DOI: 10.1021/Acs.Jctc.7B00874 |
0.438 |
|
| 2017 |
Wolloscheck D, Krishnamoorthy G, Nguyen J, Zgurskaya HI. Kinetic control of quorum sensing in Pseudomonas aeruginosa by multidrug efflux pumps. Acs Infectious Diseases. PMID 29115136 DOI: 10.1021/Acsinfecdis.7B00160 |
0.671 |
|
| 2017 |
Krishnamoorthy G, Leus IV, Weeks JW, Wolloscheck D, Rybenkov VV, Zgurskaya HI. Synergy between Active Efflux and Outer Membrane Diffusion Defines Rules of Antibiotic Permeation into Gram-Negative Bacteria. Mbio. 8. PMID 29089426 DOI: 10.1128/Mbio.01172-17 |
0.681 |
|
| 2017 |
Westfall DA, Krishnamoorthy G, Wolloscheck D, Sarkar R, Zgurskaya HI, Rybenkov VV. Bifurcation kinetics of drug uptake by Gram-negative bacteria. Plos One. 12: e0184671. PMID 28926596 DOI: 10.1371/Journal.Pone.0184671 |
0.707 |
|
| 2017 |
Haynes KM, Abdali N, Jhawar V, Zgurskaya HI, Parks JM, Green AT, Baudry JY, Rybenkov VV, Smith JC, Walker JK. Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli. Journal of Medicinal Chemistry. PMID 28650638 DOI: 10.1021/Acs.Jmedchem.7B00453 |
0.517 |
|
| 2016 |
Abdali N, Parks JM, Haynes K, Chaney JL, Green AT, Wolloscheck D, Walker JK, Rybenkov VV, Baudry JY, Smith JC, Zgurskaya HI. Reviving antibiotics: efflux pump inhibitors that interact with AcrA, a membrane fusion protein of the AcrAB-TolC multidrug efflux pump. Acs Infectious Diseases. PMID 27768847 DOI: 10.1021/Acsinfecdis.6B00167 |
0.605 |
|
| 2016 |
Belardinelli JM, Yazidi A, Yang L, Fabre L, Li W, Jacques B, Angala SK, Rouiller I, Zgurskaya HI, Sygusch J, Jackson M. Structure-Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis. Acs Infectious Diseases. 2: 702-713. PMID 27737557 DOI: 10.1021/Acsinfecdis.6B00095 |
0.52 |
|
| 2016 |
Krishnamoorthy G, Wolloscheck D, Weeks JW, Croft C, Rybenkov VV, Zgurskaya HI. Breaking the permeability barrier of Escherichia coli by controlled hyperporination of the outer membrane. Antimicrobial Agents and Chemotherapy. PMID 27697764 DOI: 10.1128/Aac.01882-16 |
0.721 |
|
| 2016 |
Ntreh AT, Weeks JW, Nickels LM, Zgurskaya HI. Opening the channel: the two functional interfaces of Pseudomonas aeruginosa OpmH with the triclosan efflux pump TriABC. Journal of Bacteriology. PMID 27645384 DOI: 10.1128/Jb.00535-16 |
0.609 |
|
| 2016 |
Zhao H, Clevenger A, Ritchey JW, Zgurskaya HI, Rybenkov VV. Pseudomonas aeruginosa condensins support opposite differentiation states. Journal of Bacteriology. PMID 27528506 DOI: 10.1128/Jb.00448-16 |
0.348 |
|
| 2016 |
Petrushenko ZM, Zhao H, Zgurskaya HI, Rybenkov VV. Novobiocin susceptibility of MukBEF deficient Escherichia coli is combinatorial with efflux and resides in DNA topoisomerases. Antimicrobial Agents and Chemotherapy. PMID 26926630 DOI: 10.1128/Aac.03102-15 |
0.398 |
|
| 2016 |
Lopez Bautista CA, Gnanakaran S, Zgurskaya H. Molecular Insights into the Low Permeability Barrier of Gram-Negative Pathogens Biophysical Journal. 110: 35a. DOI: 10.1016/J.Bpj.2015.11.258 |
0.501 |
|
| 2015 |
Zgurskaya HI, Löpez CA, Gnanakaran S. Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It. Acs Infectious Diseases. 1: 512-522. PMID 26925460 DOI: 10.1021/Acsinfecdis.5B00097 |
0.425 |
|
| 2015 |
Weeks JW, Nickels LM, Ntreh AT, Zgurskaya HI. Non-equivalent roles of two periplasmic subunits in the function and assembly of triclosan pump TriABC from Pseudomonas aeruginosa. Molecular Microbiology. 98: 343-56. PMID 26193906 DOI: 10.1111/Mmi.13124 |
0.642 |
|
| 2015 |
Zgurskaya HI, Weeks JW, Ntreh AT, Nickels LM, Wolloscheck D. Mechanism of coupling drug transport reactions located in two different membranes. Frontiers in Microbiology. 6: 100. PMID 25759685 DOI: 10.3389/Fmicb.2015.00100 |
0.65 |
|
| 2014 |
Yang L, Lu S, Belardinelli J, Huc-Claustre E, Jones V, Jackson M, Zgurskaya HI. RND transporters protect Corynebacterium glutamicum from antibiotics by assembling the outer membrane. Microbiologyopen. 3: 484-96. PMID 24942069 DOI: 10.1002/mbo3.182 |
0.758 |
|
| 2013 |
Lu S, Zgurskaya HI. MacA, a periplasmic membrane fusion protein of the macrolide transporter MacAB-TolC, binds lipopolysaccharide core specifically and with high affinity. Journal of Bacteriology. 195: 4865-72. PMID 23974027 DOI: 10.1128/Jb.00756-13 |
0.642 |
|
| 2013 |
Krishnamoorthy G, Tikhonova EB, Dhamdhere G, Zgurskaya HI. On the role of TolC in multidrug efflux: the function and assembly of AcrAB-TolC tolerate significant depletion of intracellular TolC protein. Molecular Microbiology. 87: 982-97. PMID 23331412 DOI: 10.1111/Mmi.12143 |
0.782 |
|
| 2013 |
Tikhonova EB, Zgurskaya HI. Assessment of multidrug efflux assemblies by surface plasmon resonance. Methods in Molecular Biology (Clifton, N.J.). 966: 133-55. PMID 23299733 DOI: 10.1007/978-1-62703-245-2_9 |
0.6 |
|
| 2012 |
Lu S, Zgurskaya HI. Role of ATP binding and hydrolysis in assembly of MacAB-TolC macrolide transporter. Molecular Microbiology. 86: 1132-43. PMID 23057817 DOI: 10.1111/Mmi.12046 |
0.702 |
|
| 2012 |
Yamada Y, Tikhonova EB, Zgurskaya HI. YknWXYZ is an unusual four-component transporter with a role in protection against sporulation-delaying-protein-induced killing of Bacillus subtilis. Journal of Bacteriology. 194: 4386-94. PMID 22707703 DOI: 10.1128/Jb.00223-12 |
0.522 |
|
| 2011 |
Bush K, Courvalin P, Dantas G, Davies J, Eisenstein B, Huovinen P, Jacoby GA, Kishony R, Kreiswirth BN, Kutter E, Lerner SA, Levy S, Lewis K, Lomovskaya O, Miller JH, ... ... Zgurskaya HI, et al. Tackling antibiotic resistance. Nature Reviews. Microbiology. 9: 894-6. PMID 22048738 DOI: 10.1038/Nrmicro2693 |
0.358 |
|
| 2011 |
Zgurskaya HI, Krishnamoorthy G, Ntreh A, Lu S. Mechanism and Function of the Outer Membrane Channel TolC in Multidrug Resistance and Physiology of Enterobacteria. Frontiers in Microbiology. 2: 189. PMID 21954395 DOI: 10.3389/Fmicb.2011.00189 |
0.782 |
|
| 2011 |
Modali SD, Zgurskaya HI. The periplasmic membrane proximal domain of MacA acts as a switch in stimulation of ATP hydrolysis by MacB transporter. Molecular Microbiology. 81: 937-51. PMID 21696464 DOI: 10.1111/J.1365-2958.2011.07744.X |
0.584 |
|
| 2011 |
Tikhonova EB, Yamada Y, Zgurskaya HI. Sequential mechanism of assembly of multidrug efflux pump AcrAB-TolC. Chemistry & Biology. 18: 454-63. PMID 21513882 DOI: 10.1016/J.Chembiol.2011.02.011 |
0.524 |
|
| 2010 |
Dhamdhere G, Krishnamoorthy G, Zgurskaya HI. Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. Antimicrobial Agents and Chemotherapy. 54: 5366-8. PMID 20876376 DOI: 10.1128/Aac.00719-10 |
0.77 |
|
| 2010 |
Dhamdhere G, Zgurskaya HI. Metabolic shutdown in Escherichia coli cells lacking the outer membrane channel TolC. Molecular Microbiology. 77: 743-54. PMID 20545840 DOI: 10.1111/J.1365-2958.2010.07245.X |
0.811 |
|
| 2009 |
Tikhonova EB, Dastidar V, Rybenkov VV, Zgurskaya HI. Kinetic control of TolC recruitment by multidrug efflux complexes. Proceedings of the National Academy of Sciences of the United States of America. 106: 16416-21. PMID 19805313 DOI: 10.1073/Pnas.0906601106 |
0.629 |
|
| 2009 |
Zgurskaya HI. Multicomponent drug efflux complexes: architecture and mechanism of assembly. Future Microbiology. 4: 919-32. PMID 19722844 DOI: 10.2217/Fmb.09.62 |
0.655 |
|
| 2009 |
Ge Q, Yamada Y, Zgurskaya H. The C-terminal domain of AcrA is essential for the assembly and function of the multidrug efflux pump AcrAB-TolC. Journal of Bacteriology. 191: 4365-71. PMID 19411330 DOI: 10.1128/Jb.00204-09 |
0.636 |
|
| 2009 |
Zgurskaya HI. Mechanisms of drug efflux and strategies to combat them. Preface. Biochimica Et Biophysica Acta. 1794: 723-4. PMID 19380106 DOI: 10.1016/J.Bbapap.2009.03.017 |
0.308 |
|
| 2009 |
Zgurskaya HI. Covalently linked AcrB giant offers a new powerful tool for mechanistic analysis of multidrug efflux in bacteria. Journal of Bacteriology. 191: 1727-8. PMID 19136595 DOI: 10.1128/Jb.01718-08 |
0.505 |
|
| 2009 |
Zgurskaya HI, Yamada Y, Tikhonova EB, Ge Q, Krishnamoorthy G. Structural and functional diversity of bacterial membrane fusion proteins. Biochimica Et Biophysica Acta. 1794: 794-807. PMID 19041958 DOI: 10.1016/J.Bbapap.2008.10.010 |
0.802 |
|
| 2008 |
Krishnamoorthy G, Tikhonova EB, Zgurskaya HI. Fitting periplasmic membrane fusion proteins to inner membrane transporters: mutations that enable Escherichia coli AcrA to function with Pseudomonas aeruginosa MexB. Journal of Bacteriology. 190: 691-8. PMID 18024521 DOI: 10.1128/Jb.01276-07 |
0.712 |
|
| 2007 |
Dastidar V, Mao W, Lomovskaya O, Zgurskaya HI. Drug-induced conformational changes in multidrug efflux transporter AcrB from Haemophilus influenzae. Journal of Bacteriology. 189: 5550-8. PMID 17526713 DOI: 10.1128/Jb.00471-07 |
0.625 |
|
| 2007 |
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI. Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB. Molecular Microbiology. 63: 895-910. PMID 17214741 DOI: 10.1111/J.1365-2958.2006.05549.X |
0.683 |
|
| 2007 |
Lomovskaya O, Zgurskaya HI, Totrov M, Watkins WJ. Waltzing transporters and 'the dance macabre' between humans and bacteria. Nature Reviews. Drug Discovery. 6: 56-65. PMID 17159924 DOI: 10.1038/Nrd2200 |
0.466 |
|
| 2006 |
Mikolosko J, Bobyk K, Zgurskaya HI, Ghosh P. Conformational flexibility in the multidrug efflux system protein AcrA. Structure (London, England : 1993). 14: 577-87. PMID 16531241 DOI: 10.1016/J.Str.2005.11.015 |
0.548 |
|
| 2005 |
Lau SY, Zgurskaya HI. Cell division defects in Escherichia coli deficient in the multidrug efflux transporter AcrEF-TolC. Journal of Bacteriology. 187: 7815-25. PMID 16267305 DOI: 10.1128/Jb.187.22.7815-7825.2005 |
0.752 |
|
| 2004 |
Zakharov SD, Eroukova VY, Rokitskaya TI, Zhalnina MV, Sharma O, Loll PJ, Zgurskaya HI, Antonenko YN, Cramer WA. Colicin occlusion of OmpF and TolC channels: outer membrane translocons for colicin import. Biophysical Journal. 87: 3901-11. PMID 15465872 DOI: 10.1529/Biophysj.104.046151 |
0.465 |
|
| 2004 |
Tikhonova EB, Zgurskaya HI. AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex. The Journal of Biological Chemistry. 279: 32116-24. PMID 15155734 DOI: 10.1074/Jbc.M402230200 |
0.512 |
|
| 2003 |
Ip H, Stratton K, Zgurskaya H, Liu J. pH-induced conformational changes of AcrA, the membrane fusion protein of Escherichia coli multidrug efflux system. The Journal of Biological Chemistry. 278: 50474-82. PMID 14523004 DOI: 10.1074/Jbc.M305152200 |
0.475 |
|
| 2003 |
Zgurskaya HI, Krishnamoorthy G, Tikhonova EB, Lau SY, Stratton KL. Mechanism of antibiotic efflux in Gram-negative bacteria. Frontiers in Bioscience : a Journal and Virtual Library. 8: s862-73. PMID 12957812 DOI: 10.2741/1134 |
0.811 |
|
| 2003 |
Yu EW, McDermott G, Zgurskaya HI, Nikaido H, Koshland DE. Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump Science. 300: 976-980. PMID 12738864 DOI: 10.1126/Science.1083137 |
0.339 |
|
| 2002 |
Lomovskaya O, Zgurskaya HI, Nikaido H. It takes three to tango Nature Biotechnology. 20: 1210-1212. PMID 12454673 DOI: 10.1038/Nbt1202-1210 |
0.418 |
|
| 2002 |
Tikhonova EB, Wang Q, Zgurskaya HI. Chimeric analysis of the multicomponent multidrug efflux transporters from gram-negative bacteria. Journal of Bacteriology. 184: 6499-507. PMID 12426337 DOI: 10.1128/Jb.184.23.6499-6507.2002 |
0.616 |
|
| 2002 |
Zgurskaya HI, Nikaido H. Mechanistic parallels in bacterial and human multidrug efflux transporters Current Protein and Peptide Science. 3: 531-540. PMID 12370000 DOI: 10.2174/1389203023380512 |
0.421 |
|
| 2002 |
Zgurskaya HI. Molecular analysis of efflux pump-based antibiotic resistance. International Journal of Medical Microbiology : Ijmm. 292: 95-105. PMID 12195740 DOI: 10.1078/1438-4221-00195 |
0.648 |
|
| 2001 |
Avila-Sakar AJ, Misaghi S, Wilson-Kubalek EM, Downing KH, Zgurskaya H, Nikaido H, Nogales E. Lipid-layer crystallization and preliminary three-dimensional structural analysis of AcrA, the periplasmic component of a bacterial multidrug efflux pump Journal of Structural Biology. 136: 81-88. PMID 11858709 DOI: 10.1006/Jsbi.2001.4418 |
0.364 |
|
| 2000 |
Zgurskaya HI, Nikaido H. Multidrug resistance mechanisms: Drug efflux across two membranes Molecular Microbiology. 37: 219-225. PMID 10931319 DOI: 10.1046/J.1365-2958.2000.01926.X |
0.655 |
|
| 2000 |
Zgurskaya HI, Nikaido H. Cross-linked complex between oligomeric periplasmic lipoprotein AcrA and the inner-membrane-associated multidrug efflux pump AcrB from Escherichia coli Journal of Bacteriology. 182: 4264-4267. PMID 10894736 DOI: 10.1128/Jb.182.15.4264-4267.2000 |
0.62 |
|
| 1999 |
Nikaido H, Zgurskaya HI. Antibiotic efflux mechanisms. Current Opinion in Infectious Diseases. 12: 529-36. PMID 17035817 DOI: 10.1097/00001432-199912000-00001 |
0.447 |
|
| 1999 |
Zgurskaya HI, Nikaido H. Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 96: 7190-5. PMID 10377390 DOI: 10.1073/Pnas.96.13.7190 |
0.545 |
|
| 1999 |
Zgurskaya HI, Nikaido H. AcrA is a highly asymmetric protein capable of spanning the periplasm. Journal of Molecular Biology. 285: 409-20. PMID 9878415 DOI: 10.1006/Jmbi.1998.2313 |
0.591 |
|
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