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Mark K. Schlegel, Ph.D. - Publications

Affiliations: 
2009 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Organic Chemistry, Biochemistry
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14 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Egli M, Schlegel MK, Manoharan M. Acyclic (S)-Glycol Nucleic Acid (S-GNA) Modification of siRNAs Improves the Safety of RNAi Therapeutics While Maintaining Potency. Rna (New York, N.Y.). PMID 36725319 DOI: 10.1261/rna.079526.122  0.354
2017 Schlegel MK, Foster DJ, Kel'in AV, Zlatev I, Bisbe A, Jayaraman M, Lackey JG, Rajeev KG, Charisse K, Harp J, Pallan PS, Maier MA, Egli M, Manoharan M. Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA. Journal of the American Chemical Society. PMID 28570818 DOI: 10.1021/Jacs.7B02694  0.424
2017 Hahm HS, Schlegel MK, Hurevich M, Eller S, Schuhmacher F, Hofmann J, Pagel K, Seeberger PH. Automated glycan assembly using the Glyconeer 2.1 synthesizer. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396442 DOI: 10.1073/Pnas.1700141114  0.331
2014 Yu H, Schlegel MK, McLaughlin LW. The synthesis and structural characterization of both diastereomers of 5′-(hydroxymethyl)-6,5′-cyclo-2′,5′-dideoxyuridine cyclonucleosides Rsc Advances. 4: 32588-32593. DOI: 10.1039/C4Ra04784B  0.379
2013 Yueh H, Pal A, Chang K, Schlegel MK, McLaughlin LW. Synthesis and NMR assignment of the two diastereomers of 8,6′-Cyclo-2′,6′-Dideoxyadenosine Nucleosides, Nucleotides and Nucleic Acids. 32: 320-332. PMID 23638925 DOI: 10.1080/15257770.2013.778997  0.324
2013 Doknic D, Abramo M, Sutkeviciute I, Reinhardt A, Guzzi C, Schlegel MK, Potenza D, Nieto PM, Fieschi F, Seeberger PH, Bernardi A. Synthesis and characterization of linker-armed fucose-based glycomimetics European Journal of Organic Chemistry. 5303-5314. DOI: 10.1002/Ejoc.201300236  0.344
2011 Schlegel MK, Hütter J, Eriksson M, Lepenies B, Seeberger PH. Defined presentation of carbohydrates on a duplex DNA scaffold. Chembiochem : a European Journal of Chemical Biology. 12: 2791-800. PMID 22052782 DOI: 10.1002/Cbic.201100511  0.395
2011 Johnson AT, Schlegel MK, Meggers E, Essen LO, Wiest O. On the structure and dynamics of duplex GNA. The Journal of Organic Chemistry. 76: 7964-74. PMID 21838272 DOI: 10.1021/Jo201469B  0.575
2010 Schlegel MK, Essen LO, Meggers E. Atomic resolution duplex structure of the simplified nucleic acid GNA. Chemical Communications (Cambridge, England). 46: 1094-6. PMID 20126724 DOI: 10.1039/B916851F  0.554
2009 Schlegel MK, Meggers E. Improved phosphoramidite building blocks for the synthesis of the simplified nucleic acid GNA. The Journal of Organic Chemistry. 74: 4615-8. PMID 19441799 DOI: 10.1021/Jo900365A  0.536
2009 Schlegel MK, Zhang L, Pagano N, Meggers E. Metal-mediated base pairing within the simplified nucleic acid GNA. Organic & Biomolecular Chemistry. 7: 476-82. PMID 19156312 DOI: 10.1039/B816142A  0.593
2009 Schlegel MK, Xie X, Zhang L, Meggers E. Insight into the high duplex stability of the simplified nucleic acid GNA. Angewandte Chemie (International Ed. in English). 48: 960-3. PMID 19130516 DOI: 10.1002/Anie.200803472  0.554
2008 Schlegel MK, Essen LO, Meggers E. Duplex structure of a minimal nucleic acid. Journal of the American Chemical Society. 130: 8158-9. PMID 18529005 DOI: 10.1021/Ja802788G  0.621
2007 Schlegel MK, Peritz AE, Kittigowittana K, Zhang L, Meggers E. Duplex formation of the simplified nucleic acid GNA. Chembiochem : a European Journal of Chemical Biology. 8: 927-32. PMID 17465439 DOI: 10.1002/Cbic.200600435  0.58
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