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Gene S. Tan, Ph.D. - Publications

Affiliations: 
2007 Thomas Jefferson University, Philadelphia, PA, United States 
Area:
Virology Biology, Microbiology Biology, Molecular Biology
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55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Lee CY, Raghunathan V, Caceres CJ, Geiger G, Seibert B, Cargnin Faccin F, Gay LC, Ferreri LM, Kaul D, Wrammert J, Tan GS, Perez DR, Lowen AC. Epistasis reduces fitness costs of influenza A virus escape from stem-binding antibodies. Proceedings of the National Academy of Sciences of the United States of America. 120: e2208718120. PMID 37068231 DOI: 10.1073/pnas.2208718120  0.319
2022 Sievers BL, Chakraborty S, Xue Y, Gelbart T, Gonzalez JC, Cassidy AG, Golan Y, Prahl M, Gaw SL, Arunachalam PS, Blish CA, Boyd SD, Davis MM, Jagannathan P, Nadeau KC, ... ... Tan GS, et al. Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses. Science Translational Medicine. eabn7842. PMID 35025672 DOI: 10.1126/scitranslmed.abn7842  0.381
2022 Bliss CM, Freyn AW, Caniels TG, Leyva-Grado VH, Nachbagauer R, Sun W, Tan GS, Gillespie VL, McMahon M, Krammer F, Hill AV, Palese P, Coughlan L. A single-shot adenoviral vaccine provides hemagglutinin stalk-mediated protection against heterosubtypic influenza challenge in mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 34999208 DOI: 10.1016/j.ymthe.2022.01.011  0.388
2020 Phipps KL, Ganti K, Jacobs NT, Lee CY, Carnaccini S, White MC, Manandhar M, Pickett BE, Tan GS, Ferreri LM, Perez DR, Lowen AC. Collective interactions augment influenza A virus replication in a host-dependent manner. Nature Microbiology. PMID 32632248 DOI: 10.1038/s41564-020-0749-2  0.367
2020 Duehr J, McMahon M, Williamson B, Amanat F, Durbin A, Hawman DW, Noack D, Uhl S, Tan GS, Feldmann H, Krammer F. Neutralizing Monoclonal Antibodies against the Gn and the Gc of the Andes Virus Glycoprotein Spike Complex Protect from Virus Challenge in a Preclinical Hamster Model. Mbio. 11. PMID 32209676 DOI: 10.1128/Mbio.00028-20  0.386
2019 Amanat F, Duehr J, Huang C, Paessler S, Tan G, Krammer F. Monoclonal antibodies with neutralizing activity and Fc-effector functions against the Machupo virus glycoprotein. Journal of Virology. PMID 31801871 DOI: 10.1128/Jvi.01741-19  0.451
2019 Ramos I, Smith G, Ruf-Zamojski F, Martinez-Romero C, Fribourg M, Carbajal EA, Hartmann BM, Nair VD, Marjanovic N, Monteagudo PL, DeJesus VA, Mutetwa T, Zamojski M, Tan GS, Jayaprakash C, et al. Innate immune response to influenza virus at single-cell resolution in human epithelial cells revealed paracrine induction of interferon lambda 1. Journal of Virology. PMID 31375585 DOI: 10.1128/Jvi.00559-19  0.4
2019 Bailey MJ, Broecker F, Freyn A, Choi A, Brown JA, Fedorova N, Simon V, Lim JK, Evans MJ, García-Sastre A, Palese P, Tan GS. Human monoclonal antibodies potently neutralize Zika virus and select for escape mutations on the lateral ridge of the envelope protein. Journal of Virology. PMID 31043537 DOI: 10.1128/Jvi.00405-19  0.392
2019 Bailey MJ, Broecker F, Duehr J, Arumemi F, Krammer F, Palese P, Tan GS. Antibodies Elicited by an NS1-Based Vaccine Protect Mice against Zika Virus. Mbio. 10. PMID 30940710 DOI: 10.1128/Mbio.02861-18  0.496
2018 Bailey MJ, Duehr J, Dulin H, Broecker F, Brown JA, Arumemi FO, Bermúdez González MC, Leyva-Grado VH, Evans MJ, Simon V, Lim JK, Krammer F, Hai R, Palese P, Tan GS. Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model. Nature Communications. 9: 4560. PMID 30385750 DOI: 10.1038/S41467-018-07008-0  0.463
2018 Abreu-Mota T, Hagen KR, Cooper K, Jahrling PB, Tan G, Wirblich C, Johnson RF, Schnell MJ. Non-neutralizing antibodies elicited by recombinant Lassa-Rabies vaccine are critical for protection against Lassa fever. Nature Communications. 9: 4223. PMID 30310067 DOI: 10.1038/S41467-018-06741-W  0.623
2018 Bailey MJ, Broecker F, Leon PE, Tan GS. A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies. Journal of Visualized Experiments : Jove. PMID 29553549 DOI: 10.3791/56256  0.359
2017 He W, Chen CJ, Mullarkey CE, Hamilton JR, Wong CK, Leon PE, Uccellini MB, Chromikova V, Henry C, Hoffman KW, Lim JK, Wilson PC, Miller MS, Krammer F, Palese P, ... Tan GS, et al. Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice. Nature Communications. 8: 846. PMID 29018261 DOI: 10.1038/S41467-017-00928-3  0.42
2017 Maamary J, Wang TT, Tan GS, Palese P, Ravetch JV. Increasing the breadth and potency of response to the seasonal influenza virus vaccine by immune complex immunization. Proceedings of the National Academy of Sciences of the United States of America. PMID 28874545 DOI: 10.1073/Pnas.1707950114  0.459
2017 Leon PE, Wohlbold TJ, He W, Bailey MJ, Henry CJ, Wilson PC, Krammer F, Tan GS. Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies. Journal of Visualized Experiments : Jove. PMID 28872136 DOI: 10.3791/56067  0.408
2017 Wohlbold TJ, Podolsky KA, Chromikova V, Kirkpatrick E, Falconieri V, Meade P, Amanat F, Tan J, tenOever BR, Tan GS, Subramaniam S, Palese P, Krammer F. Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes. Nature Microbiology. PMID 28827718 DOI: 10.1038/S41564-017-0011-8  0.346
2017 Goff PH, Hayashi T, He W, Yao S, Cottam HB, Tan GS, Crain B, Krammer F, Messer K, Pu M, Carson DA, Palese P, Corr M. Synthetic TLR4 and TLR7 ligands work additively via MyD88 to induce protective antiviral immunity in mice. Journal of Virology. PMID 28724768 DOI: 10.1128/Jvi.01050-17  0.411
2017 Tran E, Podolsky K, Bartesaghi A, Kuybeda O, Grandinetti G, John Wohlbold T, Tan G, Nachbagauer R, Palese P, Krammer F, Subramaniam S. Cryo-EM Tomographic Analysis of a Universal Influenza Virus Vaccine Candidate Biophysical Journal. 112: 577a. DOI: 10.1016/J.Bpj.2016.11.3105  0.347
2016 He W, Tan GS, Mullarkey CE, Lee AJ, Lam MM, Krammer F, Henry C, Wilson PC, Ashkar AA, Palese P, Miller MS. Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus. Proceedings of the National Academy of Sciences of the United States of America. PMID 27698132 DOI: 10.1073/Pnas.1609316113  0.367
2016 Leon PE, He W, Mullarkey CE, Bailey MJ, Miller MS, Krammer F, Palese P, Tan GS. Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact. Proceedings of the National Academy of Sciences of the United States of America. PMID 27647907 DOI: 10.1073/Pnas.1613225113  0.322
2016 Henry Dunand CJ, Leon PE, Huang M, Choi A, Chromikova V, Ho IY, Tan GS, Cruz J, Hirsh A, Zheng NY, Mullarkey CE, Ennis FA, Terajima M, Treanor JJ, Topham DJ, et al. Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection. Cell Host & Microbe. 19: 800-813. PMID 27281570 DOI: 10.1016/J.Chom.2016.05.014  0.372
2016 Tan GS, Leon PE, Albrecht RA, Margine I, Hirsh A, Bahl J, Krammer F. Broadly-Reactive Neutralizing and Non-neutralizing Antibodies Directed against the H7 Influenza Virus Hemagglutinin Reveal Divergent Mechanisms of Protection. Plos Pathogens. 12: e1005578. PMID 27081859 DOI: 10.1371/Journal.Ppat.1005578  0.367
2016 Chen CJ, Ermler ME, Tan GS, Krammer F, Palese P, Hai R. Influenza A viruses expressing intra- or inter-group chimeric hemagglutinins. Journal of Virology. PMID 26764009 DOI: 10.1128/Jvi.03060-15  0.38
2016 Wohlbold TJ, Chromikova V, Tan GS, Meade P, Amanat F, Comella P, Hirsh A, Krammer F. Hemagglutinin stalk- and neuraminidase-specific monoclonal antibodies protect against lethal H10N8 influenza virus infection in mice Journal of Virology. 90: 851-861. DOI: 10.1128/JVI.02275-15  0.395
2015 Wohlbold TJ, Chromikova V, Tan GS, Meade P, Amanat F, Comella P, Hirsh A, Krammer F. Hemagglutinin Stalk- and Neuraminidase-Specific Monoclonal Antibodies Protect against Lethal H10N8 Influenza Virus Infection in Mice. Journal of Virology. 90: 851-61. PMID 26512088 DOI: 10.1128/JVI.02275-15  0.339
2015 Wang TT, Maamary J, Tan GS, Bournazos S, Davis CW, Krammer F, Schlesinger SJ, Palese P, Ahmed R, Ravetch JV. Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy. Cell. 162: 160-9. PMID 26140596 DOI: 10.1016/J.Cell.2015.06.026  0.341
2015 Wohlbold TJ, Nachbagauer R, Margine I, Tan GS, Hirsh A, Krammer F. Vaccination with soluble headless hemagglutinin protects mice from challenge with divergent influenza viruses. Vaccine. 33: 3314-21. PMID 26026378 DOI: 10.1016/J.Vaccine.2015.05.038  0.447
2015 Leyva-Grado VH, Tan GS, Leon PE, Yondola M, Palese P. Direct administration in the respiratory tract improves efficacy of broadly neutralizing anti-influenza virus monoclonal antibodies. Antimicrobial Agents and Chemotherapy. 59: 4162-72. PMID 25941218 DOI: 10.1128/Aac.00290-15  0.355
2015 Wohlbold TJ, Nachbagauer R, Xu H, Tan GS, Hirsh A, Brokstad KA, Cox RJ, Palese P, Krammer F. Vaccination with adjuvanted recombinant neuraminidase induces broad heterologous, but not heterosubtypic, cross-protection against influenza virus infection in mice. Mbio. 6: e02556. PMID 25759506 DOI: 10.1128/Mbio.02556-14  0.406
2015 Henry Dunand CJ, Leon PE, Kaur K, Tan GS, Zheng NY, Andrews S, Huang M, Qu X, Huang Y, Salgado-Ferrer M, Ho IY, Taylor W, Hai R, Wrammert J, Ahmed R, et al. Preexisting human antibodies neutralize recently emerged H7N9 influenza strains. The Journal of Clinical Investigation. 125: 1255-68. PMID 25689254 DOI: 10.1172/Jci74374  0.341
2014 Tan GS, Lee PS, Hoffman RM, Mazel-Sanchez B, Krammer F, Leon PE, Ward AB, Wilson IA, Palese P. Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin. Journal of Virology. 88: 13580-92. PMID 25210195 DOI: 10.1128/Jvi.02289-14  0.405
2014 Krammer F, Albrecht RA, Tan GS, Margine I, Hai R, Schmolke M, Runstadler J, Andrews SF, Wilson PC, Cox RJ, Treanor JJ, García-Sastre A, Palese P. Divergent H7 immunogens offer protection from H7N9 virus challenge. Journal of Virology. 88: 3976-85. PMID 24453375 DOI: 10.1128/Jvi.03095-13  0.373
2014 DiLillo DJ, Tan GS, Palese P, Ravetch JV. Broadly neutralizing hemagglutinin stalk-specific antibodies require FcγR interactions for protection against influenza virus in vivo. Nature Medicine. 20: 143-51. PMID 24412922 DOI: 10.1038/Nm.3443  0.318
2014 Krammer F, Hai R, Yondola M, Tan GS, Leyva-Grado VH, Ryder AB, Miller MS, Rose JK, Palese P, García-Sastre A, Albrecht RA. Assessment of influenza virus hemagglutinin stalk-based immunity in ferrets. Journal of Virology. 88: 3432-42. PMID 24403585 DOI: 10.1128/Jvi.03004-13  0.431
2013 Margine I, Krammer F, Hai R, Heaton NS, Tan GS, Andrews SA, Runstadler JA, Wilson PC, Albrecht RA, García-Sastre A, Palese P. Hemagglutinin stalk-based universal vaccine constructs protect against group 2 influenza A viruses. Journal of Virology. 87: 10435-46. PMID 23903831 DOI: 10.1128/Jvi.01715-13  0.398
2013 Heaton NS, Leyva-Grado VH, Tan GS, Eggink D, Hai R, Palese P. In vivo bioluminescent imaging of influenza a virus infection and characterization of novel cross-protective monoclonal antibodies. Journal of Virology. 87: 8272-81. PMID 23698304 DOI: 10.1128/Jvi.00969-13  0.392
2012 Schneemann A, Speir JA, Tan GS, Khayat R, Ekiert DC, Matsuoka Y, Wilson IA. A virus-like particle that elicits cross-reactive antibodies to the conserved stem of influenza virus hemagglutinin. Journal of Virology. 86: 11686-97. PMID 22896619 DOI: 10.1128/Jvi.01694-12  0.381
2012 Krammer F, Pica N, Hai R, Tan GS, Palese P. Hemagglutinin Stalk-Reactive Antibodies Are Boosted following Sequential Infection with Seasonal and Pandemic H1N1 Influenza Virus in Mice. Journal of Virology. 86: 10302-7. PMID 22787225 DOI: 10.1128/Jvi.01336-12  0.407
2012 Tan GS, Krammer F, Eggink D, Kongchanagul A, Moran TM, Palese P. A pan-H1 anti-hemagglutinin monoclonal antibody with potent broad-spectrum efficacy in vivo. Journal of Virology. 86: 6179-88. PMID 22491456 DOI: 10.1128/Jvi.00469-12  0.341
2012 Hai R, Krammer F, Tan GS, Pica N, Eggink D, Maamary J, Margine I, Albrecht RA, Palese P. Influenza viruses expressing chimeric hemagglutinins: globular head and stalk domains derived from different subtypes. Journal of Virology. 86: 5774-81. PMID 22398287 DOI: 10.1128/Jvi.00137-12  0.306
2012 Pica N, Hai R, Krammer F, Wang TT, Maamary J, Eggink D, Tan GS, Krause JC, Moran T, Stein CR, Banach D, Wrammert J, Belshe RB, García-Sastre A, Palese P. Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses. Proceedings of the National Academy of Sciences of the United States of America. 109: 2573-8. PMID 22308500 DOI: 10.1073/Pnas.1200039109  0.377
2010 Wang TT, Tan GS, Hai R, Pica N, Ngai L, Ekiert DC, Wilson IA, García-Sastre A, Moran TM, Palese P. Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes. Proceedings of the National Academy of Sciences of the United States of America. 107: 18979-84. PMID 20956293 DOI: 10.1073/Pnas.1013387107  0.411
2010 Wang TT, Tan GS, Hai R, Pica N, Petersen E, Moran TM, Palese P. Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins. Plos Pathogens. 6: e1000796. PMID 20195520 DOI: 10.1371/Journal.Ppat.1000796  0.422
2010 Préhaud C, Wolff N, Terrien E, Lafage M, Mégret F, Babault N, Cordier F, Tan GS, Maitrepierre E, Ménager P, Chopy D, Hoos S, England P, Delepierre M, Schnell MJ, et al. Attenuation of rabies virulence: takeover by the cytoplasmic domain of its envelope protein. Science Signaling. 3: ra5. PMID 20086240 DOI: 10.1126/Scisignal.2000510  0.591
2009 Cenna J, Hunter M, Tan GS, Papaneri AB, Ribka EP, Schnell MJ, Marx PA, McGettigan JP. Replication-deficient rabies virus-based vaccines are safe and immunogenic in mice and nonhuman primates. The Journal of Infectious Diseases. 200: 1251-60. PMID 19764884 DOI: 10.1086/605949  0.639
2009 Preuss MA, Faber ML, Tan GS, Bette M, Dietzschold B, Weihe E, Schnell MJ. Intravenous inoculation of a bat-associated rabies virus causes lethal encephalopathy in mice through invasion of the brain via neurosecretory hypothalamic fibers. Plos Pathogens. 5: e1000485. PMID 19543379 DOI: 10.1371/Journal.Ppat.1000485  0.599
2008 Cenna J, Tan GS, Papaneri AB, Dietzschold B, Schnell MJ, McGettigan JP. Immune modulating effect by a phosphoprotein-deleted rabies virus vaccine vector expressing two copies of the rabies virus glycoprotein gene. Vaccine. 26: 6405-14. PMID 18804506 DOI: 10.1016/J.Vaccine.2008.08.069  0.689
2008 Wirblich C, Tan GS, Papaneri A, Godlewski PJ, Orenstein JM, Harty RN, Schnell MJ. PPEY motif within the rabies virus (RV) matrix protein is essential for efficient virion release and RV pathogenicity. Journal of Virology. 82: 9730-8. PMID 18667490 DOI: 10.1128/Jvi.00889-08  0.639
2008 Snook AE, Stafford BJ, Li P, Tan G, Huang L, Birbe R, Schulz S, Schnell MJ, Thakur M, Rothstein JL, Eisenlohr LC, Waldman SA. Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity. Journal of the National Cancer Institute. 100: 950-61. PMID 18577748 DOI: 10.1093/Jnci/Djn178  0.524
2008 Preuss MA, Faber M, Tan GS, Dietzschold B, Schnell MJ, Weihe E. Intravenous inoculation of silver-haired bat rabies virus, but not of a canine strain, elicits lethal encephalophathy in mice by fast brain invasion via neurosecretory hypothalamic fibers Bmc Proceedings. 2. DOI: 10.1186/1753-6561-2-s1-s35  0.534
2008 Prehaud C, Lafage M, Tan GS, Mégret F, Ménager P, Schnell M, Buc H, Lafon M. The cytoplasmic tail of the rabies virus G protein is an essential domain controlling death/survival in human neuronal cells Bmc Proceedings. 2. DOI: 10.1186/1753-6561-2-s1-p57  0.545
2007 Tan GS, Preuss MA, Williams JC, Schnell MJ. The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription. Proceedings of the National Academy of Sciences of the United States of America. 104: 7229-34. PMID 17438267 DOI: 10.1073/Pnas.0701397104  0.621
2005 Schnell MJ, Tan GS, Dietzschold B. The application of reverse genetics technology in the study of rabies virus (RV) pathogenesis and for the development of novel RV vaccines. Journal of Neurovirology. 11: 76-81. PMID 15804964 DOI: 10.1080/13550280590900436  0.626
2005 Tan GS, McKenna PM, Koser ML, McLinden R, Kim JH, McGettigan JP, Schnell MJ. Strong cellular and humoral anti-HIV Env immune responses induced by a heterologous rhabdoviral prime-boost approach. Virology. 331: 82-93. PMID 15582655 DOI: 10.1016/J.Virol.2004.10.018  0.687
2004 Koser ML, McGettigan JP, Tan GS, Smith ME, Koprowski H, Dietzschold B, Schnell MJ. Rabies virus nucleoprotein as a carrier for foreign antigens Proceedings of the National Academy of Sciences of the United States of America. 101: 9405-9410. PMID 15197258 DOI: 10.1073/Pnas.0403060101  0.657
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