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Ryan S. Funk, Ph.D. - Publications

Affiliations: 
2011 Pharmaceutical Chemistry University of Kansas, Lawrence, KS, United States 
Area:
Pharmacy, Pharmacology, Toxicology
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17 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Shakhnovich V, Meibohm B, Rosenberg A, Kierzek AM, Hasenkamp R, Funk RS, Thalhauser CJ, van der Graaf PH, Wang YC, Hamuro L. Immunogenicity in Clinical Practice and Drug Development: When is it Significant? Clinical and Translational Science. PMID 31762152 DOI: 10.1111/Cts.12717  0.441
2019 Funk RS, Singh RK, Becker ML. Metabolomic Profiling to Identify Molecular Biomarkers of Cellular Response to Methotrexate In Vitro. Clinical and Translational Science. PMID 31651077 DOI: 10.1111/Cts.12694  0.305
2019 Singh RK, van Haandel L, Kiptoo P, Becker ML, Siahaan TJ, Funk RS. Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model. European Journal of Pharmacology. PMID 30951714 DOI: 10.1016/J.Ejphar.2019.03.052  0.339
2018 Singh RK, van Haandel L, Heruth DP, Ye SQ, Leeder JS, Becker ML, Funk RS. Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Anti-proliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP. The Journal of Pharmacology and Experimental Therapeutics. PMID 29420256 DOI: 10.1124/Jpet.117.246199  0.336
2016 Funk RS, Singh R, Pramann L, Gigliotti N, Islam S, Heruth DP, Ye SQ, Chan MA, Leeder JS, Becker ML. Nicotinamide Phosphoribosyltransferase Attenuates Methotrexate Response in Juvenile Idiopathic Arthritis and In Vitro. Clinical and Translational Science. PMID 27166432 DOI: 10.1111/Cts.12399  0.317
2016 Funk RS, Becker ML. Disease modifying anti-rheumatic drugs in juvenile idiopathic arthritis: striving for individualized therapy Expert Review of Precision Medicine and Drug Development. 1: 53-68. DOI: 10.1080/23808993.2016.1133234  0.306
2015 Funk R. Re-Engineering Clinical Trials: Best Practices for Streamlining the Development Process American Journal of Health-System Pharmacy. 72: 1240-1241. DOI: 10.1093/Ajhp/72.14.1240A  0.314
2014 Funk RS, van Haandel L, Leeder JS, Becker ML. Folate depletion and increased glutamation in juvenile idiopathic arthritis patients treated with methotrexate. Arthritis & Rheumatology (Hoboken, N.J.). 66: 3476-85. PMID 25186097 DOI: 10.1002/Art.38865  0.315
2013 Funk RS, van Haandel L, Becker ML, Leeder JS. Low-dose methotrexate results in the selective accumulation of aminoimidazole carboxamide ribotide in an erythroblastoid cell line. The Journal of Pharmacology and Experimental Therapeutics. 347: 154-63. PMID 23887097 DOI: 10.1124/Jpet.113.206672  0.341
2013 Kazmi F, Hensley T, Pope C, Funk RS, Loewen GJ, Buckley DB, Parkinson A. Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells). Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 897-905. PMID 23378628 DOI: 10.1124/Dmd.112.050054  0.566
2012 Funk RS, Brown JT, Abdel-Rahman SM. Pediatric pharmacokinetics: human development and drug disposition. Pediatric Clinics of North America. 59: 1001-16. PMID 23036241 DOI: 10.1016/J.Pcl.2012.07.003  0.481
2012 Logan R, Funk RS, Axcell E, Krise JP. Drug-drug interactions involving lysosomes: mechanisms and potential clinical implications. Expert Opinion On Drug Metabolism & Toxicology. 8: 943-58. PMID 22616667 DOI: 10.1517/17425255.2012.691165  0.675
2012 Funk RS, Krise JP. Cationic amphiphilic drugs cause a marked expansion of apparent lysosomal volume: implications for an intracellular distribution-based drug interaction. Molecular Pharmaceutics. 9: 1384-95. PMID 22449202 DOI: 10.1021/Mp200641E  0.71
2009 Goldman SD, Funk RS, Rajewski RA, Krise JP. Mechanisms of amine accumulation in, and egress from, lysosomes. Bioanalysis. 1: 1445-59. PMID 21083094 DOI: 10.4155/Bio.09.128  0.655
2007 Funk RS, Krise JP. Exposure of cells to hydrogen peroxide can increase the intracellular accumulation of drugs. Molecular Pharmaceutics. 4: 154-9. PMID 17274672 DOI: 10.1021/Mp060071Q  0.659
2005 Duvvuri M, Konkar S, Funk RS, Krise JM, Krise JP. A chemical strategy to manipulate the intracellular localization of drugs in resistant cancer cells. Biochemistry. 44: 15743-9. PMID 16313177 DOI: 10.1021/Bi051759W  0.697
2000 Funk RS. A formulary for lizards, snakes, and crocodilians The Veterinary Clinics of North America. Exotic Animal Practice. 3: 333-358, viii. PMID 11228832  0.457
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