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Tomas Ganz - Publications

Affiliations: 
Cellular & Molecular Pathology 049D University of California, Los Angeles, Los Angeles, CA 
 Medicine University of California at Los Angeles David Geffen School of Medicine 
Area:
General Biology, Pathology, Molecular Biology, Biochemistry
Website:
https://www.iron.med.ucla.edu/
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Year Citation  Score
2024 Vadivelan A, Zhang S, Srole DN, Marcus EA, Neto GC, Nemeth E, Ganz T, De Oliveira S. mutations causing hemochromatosis: variable phenotypic expression in a pair of twins. Haematologica. PMID 38450514 DOI: 10.3324/haematol.2023.284134  0.371
2024 Liu W, Wu Y, Wei H, Ma J, Feng W, Yang Q, Zhang S, Ganz T, Liu S. Lactate administration improves laboratory parameters in murine models of iron overload. Blood. PMID 38194678 DOI: 10.1182/blood.2023021695  0.44
2024 Zhang S, Liu W, Ganz T, Liu S. Exploring the relationship between hyperlactatemia and anemia. Trends in Endocrinology and Metabolism: Tem. PMID 38185594 DOI: 10.1016/j.tem.2023.12.006  0.301
2023 Sardo U, Perrier P, Cormier K, Sotin M, Personnaz J, Medjbeur T, Desquesnes A, Cannizzo L, Ruiz-Martinez M, Thevenin J, Billoré B, Jung G, Abboud E, Peyssonnaux C, Nemeth E, ... ... Ganz T, et al. The hepatokine FGL1 regulates hepcidin and iron metabolism during anemia in mice by antagonizing BMP signaling. Blood. PMID 38232308 DOI: 10.1182/blood.2023022724  0.617
2023 Barad A, Guillet R, Pressman EK, Katzman PJ, Ganz T, Nemeth E, O'Brien KO. Placental ferroportin protein abundance is associated with neonatal erythropoietic activity and iron status in newborns at high risk for iron deficiency and anemia. The American Journal of Clinical Nutrition. PMID 37890671 DOI: 10.1016/j.ajcnut.2023.10.022  0.615
2023 Srole DN, Jung G, Waring AJ, Nemeth E, Ganz T. Characterization of erythroferrone structural domains relevant to its iron-regulatory function. The Journal of Biological Chemistry. 105374. PMID 37866631 DOI: 10.1016/j.jbc.2023.105374  0.563
2023 Liu W, Zhang S, Li Q, Wu Y, Jia X, Feng W, Li Z, Shi Y, Hou Q, Ma J, Liu Y, Gao P, Ganz T, Liu S. Lactate modulates iron metabolism by binding soluble adenylyl cyclase. Cell Metabolism. PMID 37480842 DOI: 10.1016/j.cmet.2023.06.017  0.424
2023 Ganz T, Locatelli F, Arici M, Akizawa T, Reusch M. Iron Parameters in Patients Treated with Roxadustat for Anemia of Chronic Kidney Disease. Journal of Clinical Medicine. 12. PMID 37445252 DOI: 10.3390/jcm12134217  0.431
2023 Ganz T, Nemeth E. Hypoferremia of inflammation: Innate host defense against infections. Blood Cells, Molecules & Diseases. 102777. PMID 37391347 DOI: 10.1016/j.bcmd.2023.102777  0.577
2023 Sangkhae V, Fisher AL, Ganz T, Nemeth E. Iron Homeostasis During Pregnancy: Maternal, Placental, and Fetal Regulatory Mechanisms. Annual Review of Nutrition. PMID 37253681 DOI: 10.1146/annurev-nutr-061021-030404  0.556
2023 Delaney KM, Barad A, Castillo LF, Hasund CM, Guillet R, Pressman EK, Katzman PJ, Ganz T, Nemeth E, O'Brien KO. Placental Erythroferrone and Erythropoietin mRNA Expression is Not Associated with Maternal or Neonatal Iron Status in Adolescents Carrying Singletons and Adult Women Carrying Multiples. The Journal of Nutrition. PMID 37253412 DOI: 10.1016/j.tjnut.2023.05.023  0.561
2023 Sardo U, Perrier P, Cormier K, Sotin M, Desquesnes A, Cannizzo L, Ruiz-Martinez M, Thevenin J, Billoré B, Jung G, Abboud E, Peyssonnaux C, Nemeth E, Ginzburg YZ, Ganz T, et al. The hepatokine FGL1 regulates hepcidin and iron metabolism during the recovery from hemorrhage-induced anemia in mice. Biorxiv : the Preprint Server For Biology. PMID 37066218 DOI: 10.1101/2023.04.06.535920  0.619
2023 Olivera JD, Zhang V, Nemeth E, Ganz T. Erythroferrone exacerbates iron overload and ineffective extramedullary erythropoiesis in a mouse model of β-thalassemia. Blood Advances. PMID 36995275 DOI: 10.1182/bloodadvances.2022009307  0.583
2023 Azucenas CR, Ruwe TA, Bonamer JP, Qiao B, Ganz T, Jormakka M, Nemeth E, Mackenzie B. Comparative analysis of the functional properties of human and mouse ferroportin. American Journal of Physiology. Cell Physiology. PMID 36939203 DOI: 10.1152/ajpcell.00063.2023  0.597
2023 Ganz T, Nemeth E. Pathogenic Mechanisms in Thalassemia II: Iron Overload. Hematology/Oncology Clinics of North America. 37: 353-363. PMID 36907608 DOI: 10.1016/j.hoc.2022.12.006  0.604
2023 Stetka J, Usart M, Kubovcakova L, Rai S, Nageswara Rao T, Sutter J, Hao-Shen H, Dirnhofer S, Geier F, Bader MS, Passweg JR, Manolova V, Dürrenberger F, Ahmed N, Schroeder T, ... Ganz T, et al. Iron is a modifier of the phenotypes of JAK2-mutant myeloproliferative neoplasms. Blood. PMID 36758212 DOI: 10.1182/blood.2022017976  0.601
2023 Ganz T, Nemeth E, Rivella S, Goldberg P, Dibble AR, McCaleb ML, Guo S, Monia BP, Barrett TD. TMPRSS6 as a Therapeutic Target for Disorders of Erythropoiesis and Iron Homeostasis. Advances in Therapy. PMID 36690839 DOI: 10.1007/s12325-022-02421-w  0.637
2022 Zhang V, Ganz T, Nemeth E, Umar S, Kim A. Bmpr2 mutant mice are an inadequate model for studying iron deficiency in pulmonary hypertension. Pulmonary Circulation. 12: e12151. PMID 36568690 DOI: 10.1002/pul2.12151  0.689
2022 Zhang V, Jenkitkasemwong S, Liu Q, Ganz T, Nemeth E, Knutson MD, Kim A. A mouse model characterizes the roles of ZIP8 in systemic iron recycling and lung inflammation and infection. Blood Advances. PMID 36260707 DOI: 10.1182/bloodadvances.2022007867  0.741
2022 Sangkhae V, Yu V, Coffey R, O'Brien KO, Ganz T, Nemeth E. Erythroferrone contributes to iron mobilization for embryo erythropoiesis in iron-deficient mouse pregnancies. American Journal of Hematology. 97: 1348-1358. PMID 36071577 DOI: 10.1002/ajh.26680  0.623
2022 Feng W, Xiao Y, Zhao C, Zhang Z, Liu W, Ma J, Ganz T, Zhang J, Liu S. New Deferric Amine Compounds Efficiently Chelate Excess Iron to Treat Iron Overload Disorders and to Prevent Ferroptosis. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2202679. PMID 36031399 DOI: 10.1002/advs.202202679  0.438
2022 Nemeth E, Ganz T. Hepcidin and Iron in Health and Disease. Annual Review of Medicine. PMID 35905974 DOI: 10.1146/annurev-med-043021-032816  0.633
2022 Koury MJ, Agarwal R, Chertow GM, Eckardt KU, Fishbane S, Ganz T, Haase VH, Hanudel MR, Parfrey PS, Pergola PE, Roy-Chaudhury P, Tumlin JA, Anders R, Farag YMK, Luo W, et al. Erythropoietic effects of vadadustat in patients with anemia associated with chronic kidney disease. American Journal of Hematology. PMID 35751858 DOI: 10.1002/ajh.26644  0.351
2022 Fishbane S, Ganz T, Pratt RD. Ferric pyrophosphate citrate for parenteral administration of maintenance iron: structure, mechanism of action, clinical efficacy and safety. Current Medical Research and Opinion. 38: 1417-1429. PMID 35726771 DOI: 10.1080/03007995.2022.2092373  0.424
2022 Andersen AB, Bejder J, Bonne TC, Sørensen H, Sørensen H, Jung G, Ganz T, Nemeth E, Secher NH, Johansson PI, Nordsborg NB. Hepcidin and Erythroferrone Complement the Athlete Biological Passport in the Detection of Autologous Blood Transfusion. Medicine and Science in Sports and Exercise. PMID 35482790 DOI: 10.1249/MSS.0000000000002950  0.405
2022 Hanudel MR, Czaya B, Wong S, Jung G, Chua K, Qiao B, Gabayan V, Ganz T. Renoprotective effects of ferric citrate in a mouse model of chronic kidney disease. Scientific Reports. 12: 6695. PMID 35461329 DOI: 10.1038/s41598-022-10842-4  0.301
2022 Luo G, Zhang J, Wang H, Sun Y, Cheng B, Xu Z, Zhang Y, Li H, Lu W, Nemeth E, Ganz T, Fang X. Human defensin-inspired discovery of peptidomimetic antibiotics. Proceedings of the National Academy of Sciences of the United States of America. 119: e2117283119. PMID 35238683 DOI: 10.1073/pnas.2117283119  0.486
2022 Zhou A, Kong T, Fowles JS, Jung CL, Allen MJ, Fisher DAC, Fulbright M, Nemeth E, Ganz T, Oh ST. Hepcidin is elevated in primary and secondary myelofibrosis and remains elevated in patients treated with ruxolitinib. British Journal of Haematology. PMID 35128632 DOI: 10.1111/bjh.18044  0.482
2022 Zhu J, Fu Q, Wang S, Ren L, Feng W, Wei S, Zhang Z, Xu Y, Ganz T, Liu S. Palladium Nanoplate-Based IL-6 Receptor Antagonists Ameliorate Cancer-Related Anemia and Simultaneously Inhibit Cancer Progression. Nano Letters. 22: 751-760. PMID 35030010 DOI: 10.1021/acs.nanolett.1c04260  0.255
2021 Hanudel MR, Czaya B, Wong S, Rappaport M, Namjoshi S, Chua K, Jung G, Gabayan V, Qiao B, Nemeth E, Ganz T. Enteral ferric citrate absorption is dependent on the iron transport protein ferroportin. Kidney International. PMID 34838540 DOI: 10.1016/j.kint.2021.10.036  0.678
2021 Coffey R, Jung CG, Olivera JD, Karin G, Pereira RC, Nemeth E, Ganz T. Erythroid overproduction of erythroferrone causes iron overload and developmental abnormalities in mice. Blood. PMID 34614145 DOI: 10.1182/blood.2021014054  0.668
2021 Fisher AL, Srole DN, Palaskas NJ, Meriwether D, Reddy ST, Ganz T, Nemeth E. Iron loading induces cholesterol synthesis and sensitizes endothelial cells to TNFα-mediated apoptosis. The Journal of Biological Chemistry. 101156. PMID 34480898 DOI: 10.1016/j.jbc.2021.101156  0.646
2021 Ganz T. New regulators of systemic iron homeostasis. Signal Transduction and Targeted Therapy. 6: 280. PMID 34290226 DOI: 10.1038/s41392-021-00696-z  0.472
2021 Delaney KM, Guillet R, Pressman EK, Ganz T, Nemeth E, O'Brien KO. Umbilical Cord Erythroferrone Is Inversely Associated with Hepcidin, but Does Not Capture the Most Variability in Iron Status of Neonates Born to Teens Carrying Singletons and Women Carrying Multiples. The Journal of Nutrition. PMID 34236433 DOI: 10.1093/jn/nxab156  0.659
2021 Nemeth E, Ganz T. Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis. International Journal of Molecular Sciences. 22. PMID 34204327 DOI: 10.3390/ijms22126493  0.683
2021 Fisher AL, Sangkhae V, Balušíková K, Palaskas NJ, Ganz T, Nemeth E. Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy. Nature Communications. 12: 4026. PMID 34188052 DOI: 10.1038/s41467-021-24333-z  0.633
2021 Breenfeldt Andersen A, Bonne TC, Bejder J, Jung G, Ganz T, Nemeth E, Olsen NV, Rodriguez Huertas J, Nordsborg NB. Effects of altitude and recombinant human erythropoietin on iron metabolism: a randomized controlled trial. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. PMID 34160288 DOI: 10.1152/ajpregu.00070.2021  0.609
2021 Delaney KM, Guillet R, Pressman EK, Ganz T, Nemeth E, O'Brien KO. Serum Erythroferrone During Pregnancy Is Related to Erythropoietin but Does Not Predict the Risk of Anemia. The Journal of Nutrition. PMID 33982118 DOI: 10.1093/jn/nxab093  0.611
2021 Matte A, Federti E, Kung C, Kosinski PA, Narayanaswamy R, Russo R, Federico G, Carlomagno F, Desbats MA, Salviati L, Leboeuf C, Valenti MT, Turrini F, Janin A, Yu S, ... ... Ganz T, et al. The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model. The Journal of Clinical Investigation. PMID 33822774 DOI: 10.1172/JCI144206  0.374
2021 Hanudel MR, Wong S, Jung G, Qiao B, Gabayan V, Zuk A, Ganz T. Amelioration of chronic kidney disease-associated anemia by vadadustat in mice is not dependent on erythroferrone. Kidney International. PMID 33811979 DOI: 10.1016/j.kint.2021.03.019  0.473
2021 Kaunitz JD, Ganz T. Commentary on the AGA Clinical Practice Guidelines on the Gastrointestinal Evaluation of Iron Deficiency Anemia. Gastroenterology. PMID 33675744 DOI: 10.1053/j.gastro.2021.03.001  0.451
2021 Emrich IE, Scheuer A, Wagenpfeil S, Ganz T, Heine GH. Increase of plasma erythroferrone levels during high-altitude exposure - a sub-analysis of the TOP OF HOMe study. American Journal of Hematology. PMID 33606284 DOI: 10.1002/ajh.26130  0.205
2021 Goncalves Monteiro D, van Dijk JWA, Aliyanto R, Fung E, Nemeth E, Ganz T, Rosengren J, Clark RJ. Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic -Methylated Mini-Hepcidins. Biomedicines. 9. PMID 33567510 DOI: 10.3390/biomedicines9020164  0.653
2021 Kalantar-Zadeh K, Ganz T, Trumbo H, Seid MH, Goodnough LT, Levine MA. Parenteral iron therapy and phosphorus homeostasis: A review. American Journal of Hematology. PMID 33471363 DOI: 10.1002/ajh.26100  0.523
2020 Honda H, Tanaka K, Michihata T, Shibagaki K, Yuza T, Hirao K, Tomosugi N, Ganz T, Higashimoto Y. Erythropoiesis stimulating agents are associated with serum fibroblast growth factor 23 metabolism in patients on hemodialysis Ndt Plus. 14: 943-949. PMID 33777378 DOI: 10.1093/Ckj/Sfaa042  0.346
2020 Srole DN, Ganz T. Erythroferrone structure, function, and physiology: Iron homeostasis and beyond. Journal of Cellular Physiology. PMID 33372284 DOI: 10.1002/jcp.30247  0.524
2020 Deshpande CN, Azucenas CR, Qiao B, Nomura N, Xin V, Font J, Iwata S, Ganz T, Nemeth E, Mackenzie B, Jormakka M. Isolation and thermal stabilization of mouse ferroportin. Febs Open Bio. PMID 33190422 DOI: 10.1002/2211-5463.13039  0.613
2020 Ganz T. The role of hepcidin in fetal iron homeostasis. Blood. 136: 1474-1475. PMID 32970808 DOI: 10.1182/blood.2020007382  0.519
2020 Jerzak KJ, Lohmann AE, Ennis M, Nemeth E, Ganz T, Goodwin PJ. Prognostic associations of plasma hepcidin in women with early breast cancer. Breast Cancer Research and Treatment. PMID 32960376 DOI: 10.1007/S10549-020-05903-Z  0.651
2020 Oh ST, Talpaz M, Gerds AT, Gupta V, Verstovsek S, Mesa R, Miller CB, Rivera CE, Fleischman AG, Goel S, Heaney ML, O'Connell C, Arcasoy MO, Zhang Y, Kawashima J, ... Ganz T, et al. ACVR1/JAK1/JAK2 inhibitor momelotinib reverses transfusion dependency and suppresses hepcidin in myelofibrosis phase 2 trial. Blood Advances. 4: 4282-4291. PMID 32915978 DOI: 10.1182/Bloodadvances.2020002662  0.528
2020 Hsu D, Kim A, Ganz T, Suh JD, Wang M, Wu TJ, Lee JT. Expression of Iron-Regulatory Hormone Hepcidin and Iron Transporters Ferroportin and ZIP8 in Patients With and Without Chronic Rhinosinusitis. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. 194599820939910. PMID 32746765 DOI: 10.1177/0194599820939910  0.729
2020 Ganz T, Aronoff GR, Gaillard CAJM, Goodnough LT, Macdougall IC, Mayer G, Porto G, Winkelmayer WC, Wish JB. Iron Administration, Infection, and Anemia Management in CKD: Untangling the Effects of Intravenous Iron Therapy on Immunity and Infection Risk. Kidney Medicine. 2: 341-353. PMID 32734254 DOI: 10.1016/j.xkme.2020.01.006  0.501
2020 Gutschow P, Han H, Olbina G, Westerman K, Nemeth E, Ganz T, Copeland K, Westerman M, Ostland V. Clinical Immunoassay for Human Hepcidin Predicts Iron Deficiency in First-Time Blood Donors. The Journal of Applied Laboratory Medicine. PMID 32674118 DOI: 10.1093/jalm/jfaa038  0.663
2020 Sharma S, Hanudel MR, Ix JH, Salusky IB, Ganz T, Nguyen KL. The Authors Reply. Kidney International Reports. 5: 1119-1120. PMID 32647775 DOI: 10.1016/J.Ekir.2020.04.023  0.295
2020 Zhang V, Ganz T, Nemeth E, Kim A. Iron overload causes a mild and transient increase in acute lung injury. Physiological Reports. 8: e14470. PMID 32596989 DOI: 10.14814/Phy2.14470  0.773
2020 Sangkhae V, Fisher AL, Chua KJ, Ruchala P, Ganz T, Nemeth E. Maternal Hepcidin Determines Embryo Iron Homeostasis. Blood. PMID 32584957 DOI: 10.1182/Blood.2020005745  0.67
2020 Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. Author Correction: Identification of erythroferrone as an erythroid regulator of iron metabolism. Nature Genetics. PMID 32107478 DOI: 10.1038/S41588-019-0548-Y  0.589
2020 Ganz T. Drugging erythroferrone to treat anemias. Blood. 135: 516-518. PMID 32078688 DOI: 10.1182/Blood.2019004678  0.336
2020 Fisher AL, Sangkhae V, Presicce P, Chougnet CA, Jobe AH, Kallapur SG, Tabbah SM, Buhimschi CS, Buhimschi IA, Ganz T, Nemeth E. Fetal and amniotic fluid iron homeostasis in healthy and complicated murine, macaque, and human pregnancy. Jci Insight. PMID 31990688 DOI: 10.1172/Jci.Insight.135321  0.659
2020 Ruwe TA, Qiao B, Bonamer JP, Azucenas CR, Ganz T, Nemeth E, Mackenzie B. Hepcidin inhibits ferroportin in the Xenopus oocyte expression system via a calcium‐dependent mechanism that does not involve endocytosis The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04800  0.522
2019 Sharma S, Hanudel MR, Ix JH, Salusky IB, Ganz T, Nguyen KL. Elevated Fibroblast Growth Factor 23 Levels Are Associated With Greater Diastolic Dysfunction in ESRD. Kidney International Reports. 4: 1748-1751. PMID 31844812 DOI: 10.1016/J.Ekir.2019.07.022  0.325
2019 Sangkhae V, Fisher AL, Wong S, Koenig MD, Tussing-Humphreys L, Chu A, Lelić M, Ganz T, Nemeth E. Effects of maternal iron status on placental and fetal iron homeostasis. The Journal of Clinical Investigation. PMID 31661462 DOI: 10.1172/Jci127341  0.701
2019 Ganz T. Anemia of Inflammation. The New England Journal of Medicine. 381: 1148-1157. PMID 31532961 DOI: 10.1056/Nejmra1804281  0.546
2019 Pergola PE, Fishbane S, Ganz T. Novel Oral Iron Therapies for Iron Deficiency Anemia in Chronic Kidney Disease. Advances in Chronic Kidney Disease. 26: 272-291. PMID 31477258 DOI: 10.1053/J.Ackd.2019.05.002  0.58
2019 Bondu S, Alary AS, Lefèvre C, Houy A, Jung G, Lefebvre T, Rombaut D, Boussaid I, Bousta A, Guillonneau F, Perrier P, Alsafadi S, Wassef M, Margueron R, Rousseau A, ... ... Ganz T, et al. A variant erythroferrone disrupts iron homeostasis in -mutated myelodysplastic syndrome. Science Translational Medicine. 11. PMID 31292266 DOI: 10.1126/Scitranslmed.Aav5467  0.655
2019 Altamura S, Vegi NM, Hoppe PS, Schroeder T, Aichler M, Walch A, Okreglicka K, Hültner L, Schneider M, Ladinig C, Kuklik-Roos C, Mysliwietz J, Janik D, Neff F, Rathkolb B, ... ... Ganz T, et al. Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis. Haematologica. PMID 31248967 DOI: 10.3324/Haematol.2018.212977  0.511
2019 Ganz T. The Discovery of the Iron-Regulatory Hormone Hepcidin. Clinical Chemistry. PMID 31235538 DOI: 10.1373/Clinchem.2019.306407  0.497
2019 Ganz T, Bino A, Salusky IB. Mechanism of Action and Clinical Attributes of Auryxia (Ferric Citrate). Drugs. PMID 31134521 DOI: 10.1007/S40265-019-01125-W  0.52
2019 Ganz T, Ganz P. William Ganz and His Legacy. Annals of Internal Medicine. 170: 734-735. PMID 31108522 DOI: 10.7326/L19-0033  0.311
2019 Honda H, Hosaka N, Ganz T, Shibata T. Iron Metabolism in Chronic Kidney Disease Patients. Contributions to Nephrology. 198: 103-111. PMID 30991401 DOI: 10.1159/000496369  0.51
2019 Liu J, Liu W, Liu Y, Miao Y, Guo Y, Song H, Wang F, Zhou H, Ganz T, Yan B, Liu S. New thiazolidinones reduce iron overload in mouse models of hereditary hemochromatosis and β-thalassemia. Haematologica. PMID 30792208 DOI: 10.3324/Haematol.2018.209874  0.583
2019 Micewicz ED, Iwamoto KS, Ratikan JA, Nguyen C, Xie MW, Cheng G, Boxx GM, Deriu E, Damoiseaux RD, Whitelegge JP, Ruchala PP, Avetisyan R, Jung ME, Lawson G, Nemeth E, ... Ganz T, et al. The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation. Radiation Research. PMID 30730284 DOI: 10.1667/Rr15231.1  0.517
2019 Chen Q, Yang Y, Hou J, Shu Q, Yin Y, Fu W, Han F, Hou T, Zeng C, Nemeth E, Linzmeier R, Ganz T, Fang X. Increased gene copy number of worsens sepsis by inducing endothelial pyroptosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 30718392 DOI: 10.1073/Pnas.1812947116  0.555
2019 Song J, Sundar KM, Horvathova M, Tashi T, Lundby C, Ganz T, Prchal JT. Normal Hemoglobin Concentrations in Obstructive Sleep Apnea and Associated Neocytolysis-Mediated Hemolysis and Inflammation Mediated Suppression of Expected Elevated Hemoglobin Blood. 134: 3507-3507. DOI: 10.1182/Blood-2019-131269  0.449
2019 Gutschow P, Han H, Olbina G, Westerman K, Westerman E, Ruiz Martinez M, Ginzburg Y, Nemeth E, Ganz T, Ostland V. A Novel Sandwich ELISA to Quantify Erythroferrone in Mouse Serum Blood. 134: 2237-2237. DOI: 10.1182/Blood-2019-130947  0.594
2019 Thompson AA, Ganz T, Forsyth MT, Nemeth E, Badawy SM. Does Gene Therapy in Beta Thalassemia Normalize Novel Markers of Ineffective Erythropoiesis and Iron Homeostasis? Blood. 134: 816-816. DOI: 10.1182/Blood-2019-129658  0.631
2019 Busti F, Marchi G, Castagna A, Zidanes LA, Nemeth E, Ganz T, Girelli D. MULTIFACTORIAL HEPCIDIN SUPPRESSION IN BETA-THALASSEMIA CARRIERS WITH IRON OVERLOAD Hemasphere. 3: 591. DOI: 10.1097/01.HS9.0000563456.48398.ED  0.445
2018 Coffey R, Ganz T. Erythroferrone: An Erythroid Regulator of Hepcidin and Iron Metabolism. Hemasphere. 2: e35. PMID 31723763 DOI: 10.1097/HS9.0000000000000035  0.546
2018 Ganz T. Erythrocytes and erythroblasts give up iron. Blood. 132: 2004-2005. PMID 30409893 DOI: 10.1182/Blood-2018-09-876102  0.574
2018 Weiss G, Ganz T, Goodnough LT. Anemia of inflammation. Blood. PMID 30401705 DOI: 10.1182/Blood-2018-06-856500  0.564
2018 Guo Y, Zhang N, Zhang D, Ren Q, Ganz T, Liu S, Nemeth E. Iron homeostasis in pregnancy and spontaneous abortion. American Journal of Hematology. PMID 30394565 DOI: 10.1002/Ajh.25341  0.671
2018 Ganz T. Erythropoietin and iron-a conflicted alliance? Kidney International. 94: 851-853. PMID 30348300 DOI: 10.1016/J.Kint.2018.07.027  0.588
2018 Gagliano-Jucá T, Pencina KM, Ganz T, Travison TG, Kantoff PW, Nguyen PL, Taplin ME, Kibel AS, Li Z, Huang G, Edwards RR, Nemeth E, Basaria S. Mechanisms Responsible for Reduced Erythropoiesis during Androgen Deprivation Therapy in Men with Prostate Cancer. American Journal of Physiology. Endocrinology and Metabolism. PMID 30325657 DOI: 10.1152/Ajpendo.00272.2018  0.594
2018 Coffey R, Sardo U, Kautz L, Gabayan V, Nemeth E, Ganz T. Erythroferrone is not required for the glucoregulatory and hematologic effects of chronic erythropoietin treatment in mice. Physiological Reports. 6: e13890. PMID 30315639 DOI: 10.14814/Phy2.13890  0.562
2018 Deshpande CN, Ruwe TA, Shawki A, Xin V, Vieth KR, Valore EV, Qiao B, Ganz T, Nemeth E, Mackenzie B, Jormakka M. Calcium is an essential cofactor for metal efflux by the ferroportin transporter family. Nature Communications. 9: 3075. PMID 30082682 DOI: 10.1038/S41467-018-05446-4  0.659
2018 Ginzburg YZ, Feola M, Zimran E, Varkonyi J, Ganz T, Hoffman R. Dysregulated iron metabolism in polycythemia vera: etiology and consequences. Leukemia. PMID 30042411 DOI: 10.1038/S41375-018-0207-9  0.613
2018 Hanudel MR, Eisenga MF, Rappaport M, Chua K, Qiao B, Jung G, Gabayan V, Gales B, Ramos G, de Jong MA, van Zanden JJ, de Borst MH, Bakker SJL, Nemeth E, Salusky IB, ... ... Ganz T, et al. Effects of erythropoietin on fibroblast growth factor 23 in mice and humans. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. PMID 30007314 DOI: 10.1093/Ndt/Gfy189  0.516
2018 Ganz T. Erythropoietic regulators of iron metabolism. Free Radical Biology & Medicine. PMID 29981834 DOI: 10.1016/J.Freeradbiomed.2018.07.003  0.615
2018 Stefanova D, Raychev A, Deville J, Humphries R, Campeau S, Ruchala P, Nemeth E, Ganz T, Bulut Y. Hepcidin protects against lethal sepsis in mice inoculated with isolates from septic patients. Infection and Immunity. PMID 29735522 DOI: 10.1128/Iai.00253-18  0.696
2018 Cox HD, Miller GD, Lai A, Cushman D, Ganz T, Eichner D. Evaluation of serum markers for improved detection of autologous blood transfusions. Haematologica. PMID 29674501 DOI: 10.3324/Haematol.2018.190918  0.344
2018 Meznarich JA, Draper L, Christensen RD, Yaish HM, Luem ND, Pysher TJ, Jung G, Nemeth E, Ganz T, Ward DM. Fetal presentation of congenital dyserythropoietic anemia type 1 with novel compound heterozygous CDAN1 mutations. Blood Cells, Molecules & Diseases. PMID 29599085 DOI: 10.1016/J.Bcmd.2018.03.002  0.631
2018 Stasiak IM, Smith DA, Ganz T, Crawshaw GJ, Hammermueller JD, Bienzle D, Lillie BN. Iron storage disease (hemochromatosis) and hepcidin response to iron load in two species of pteropodid fruit bats relative to the common vampire bat. Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology. PMID 29594459 DOI: 10.1007/S00360-018-1155-4  0.597
2018 Adams P, Altes A, Brissot P, Butzeck B, Cabantchik I, Cançado R, Distante S, Evans P, Evans R, Ganz T, Girelli D, Hultcrantz R, McLaren G, Marris B, Milman N, et al. Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype. Hepatology International. PMID 29589198 DOI: 10.1007/S12072-018-9855-0  0.507
2018 Wish JB, Aronoff GR, Bacon BR, Brugnara C, Eckardt KU, Ganz T, Macdougall IC, Núñez J, Perahia AJ, Wood JC. Positive Iron Balance in Chronic Kidney Disease: How Much is Too Much and How to Tell? American Journal of Nephrology. 47: 72-83. PMID 29439253 DOI: 10.1159/000486968  0.533
2018 Hanudel MR, Rappaport M, Chua K, Gabayan V, Qiao B, Jung G, Salusky IB, Ganz T, Nemeth E. Levels of the erythropoietin-responsive hormone erythroferrone in mice and humans with chronic kidney disease. Haematologica. PMID 29419424 DOI: 10.3324/Haematol.2017.181743  0.684
2018 Rzymski P, Ganz T. Comment on "Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet". Biological Trace Element Research. PMID 29322429 DOI: 10.1007/S12011-018-1241-1  0.486
2018 Ganz T. Correction to: Iron and infection. International Journal of Hematology. 107: 122. PMID 29197980 DOI: 10.1007/S12185-017-2385-Z  0.371
2018 Ruiz Martinez M, An W, Feola M, Ganz T, Ginzburg Y. Additive Effects of Decreased TfR1 and Ablated Erfe Improve Both Ineffective Erythropoiesis and Iron Overload in β-Thalassemic Mice Blood. 132: 847-847. DOI: 10.1182/Blood-2018-99-119426  0.551
2018 Song J, Sundar KM, Robert C, Horvathova M, Kralova B, Divoky V, Ganz T, Prchal JT. Pathophysiology of Obstructive Sleep Apnea (OSA) - Blood Cells’ Reactive Oxygen Species and Inflammation Prevent Polycythemia Blood. 132: 1028-1028. DOI: 10.1182/Blood-2018-99-116658  0.457
2018 Oh ST, Talpaz M, Gerds AT, Gupta V, Verstovsek S, Mesa RA, Miller CB, Rivera CE, Fleischman A, Goel S, Heaney ML, O'Connell C, Arcasoy M, Zhang Y, Kawashima J, ... Ganz T, et al. Hepcidin Suppression By Momelotinib Is Associated with Increased Iron Availability and Erythropoiesis in Transfusion-Dependent Myelofibrosis Patients Blood. 132: 4282-4282. DOI: 10.1182/Blood-2018-99-111349  0.467
2017 Aschemeyer S, Qiao B, Stefanova D, Valore EV, Sek AC, Ruwe TA, Vieth KR, Jung G, Casu C, Rivella S, Jormakka M, Mackenzie B, Ganz T, Nemeth E. Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin. Blood. PMID 29237594 DOI: 10.1182/Blood-2017-05-786590  0.671
2017 Ganz T. Iron and infection. International Journal of Hematology. PMID 29147843 DOI: 10.1007/S12185-017-2366-2  0.598
2017 Clinkenbeard EL, Hanudel MR, Stayrook KR, Appaiah HN, Farrow EG, Cass TA, Summers LJ, Ip CS, Hum JM, Thomas JC, Ivan M, Richine BM, Chan RJ, Clemens TL, Schipani E, ... ... Ganz T, et al. Erythropoietin stimulates murine and human Fibroblast growth factor-23, revealing novel roles for bone and bone marrow. Haematologica. PMID 28818868 DOI: 10.3324/Haematol.2017.167882  0.5
2017 McLachlan S, Page KE, Lee SM, Loguinov A, Valore E, Hui ST, Jung G, Zhou J, Lusis AJ, Fuqua B, Ganz T, Nemeth E, Vulpe CD. Hamp1 mRNA and plasma hepcidin levels are influenced by sex and strain but don't predict tissue iron levels in inbred mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00307.2016. PMID 28798083 DOI: 10.1152/Ajpgi.00307.2016  0.669
2017 Vos JM, Tsakmaklis N, Patterson CJ, Meid K, Castillo JJ, Brodsky P, Ganz T, Pals ST, Kersten MJ, Xu L, Yang G, Treon SP, Hunter ZR. CXCL13 levels are elevated in patients with Waldenstrom's Macroglobulinemia, and are predictive of major response to ibrutinib. Haematologica. PMID 28798070 DOI: 10.3324/Haematol.2017.172627  0.366
2017 Antman EM, Di Corleto PE, Freeman MW, Ganz T, Golan DE, Kitterman R, Loscalzo J, Low M, McKenna E, O'Connor AC, Palazzolo M, Parrish J, Reizes O, Ross RS, Vaughan C, et al. NIH Centers for Accelerated Innovations Program: principles, practices, successes and challenges. Nature Reviews. Drug Discovery. PMID 28775338 DOI: 10.1038/Nrd.2017.131  0.303
2017 Ganz T, Jung G, Naeim A, Ginzburg Y, Pakbaz Z, Walter PB, Kautz L, Nemeth E. Immunoassay for human serum erythroferrone. Blood. PMID 28739636 DOI: 10.1182/Blood-2017-04-777987  0.662
2017 Chow JKL, Ganz T, Ruthazer R, Simpson MA, Pomfret EA, Gordon FD, Westerman ME, Snydman DR. Iron-Related Markers are Associated with Infection after Liver Transplantation. Liver Transplantation : Official Publication of the American Association For the Study of Liver Diseases and the International Liver Transplantation Society. PMID 28703464 DOI: 10.1002/Lt.24817  0.54
2017 Coffey R, Ganz T. Iron Homeostasis--an Anthropocentric Perspective. The Journal of Biological Chemistry. PMID 28615456 DOI: 10.1074/Jbc.R117.781823  0.603
2017 Ganz T. Does Pathological Iron Overload Impair the Function of Human Lungs? Ebiomedicine. PMID 28545989 DOI: 10.1016/J.Ebiom.2017.05.023  0.514
2017 Stefanova D, Raychev A, Arezes J, Ruchala P, Gabayan V, Skurnik M, Dillon BJ, Horwitz MA, Ganz T, Bulut Y, Nemeth E. Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron. Blood. PMID 28465342 DOI: 10.1182/Blood-2017-03-772715  0.696
2017 Khorramian E, Fung E, Chua K, Gabayan V, Ganz T, Nemeth E, Kim A. In a Mouse Model of Sepsis, Hepcidin Ablation Ameliorates Anemia More Effectively Than Iron and Erythropoietin Treatment. Shock (Augusta, Ga.). PMID 28452907 DOI: 10.1097/Shk.0000000000000886  0.742
2017 Michels KR, Zhang Z, Bettina AM, Cagnina RE, Stefanova D, Burdick MD, Vaulont S, Nemeth E, Ganz T, Mehrad B. Hepcidin-mediated iron sequestration protects against bacterial dissemination during pneumonia. Jci Insight. 2: e92002. PMID 28352667 DOI: 10.1172/Jci.Insight.92002  0.69
2017 Preziosi ME, Singh S, Valore EV, Jung CL, Popovic B, Poddar M, Nagarajan S, Ganz T, Monga SP. Mice lacking liver-specific β-catenin develop steatohepatitis and fibrosis after iron overload. Journal of Hepatology. PMID 28341391 DOI: 10.1016/J.Jhep.2017.03.012  0.569
2017 Aschemeyer S, Gabayan V, Ganz T, Nemeth E, Kautz L. Erythroferrone and matriptase-2 independently regulate hepcidin expression. American Journal of Hematology. PMID 28187515 DOI: 10.1002/Ajh.24672  0.533
2016 Hanudel MR, Rappaport M, Gabayan V, Jung G, Salusky IB, Nemeth E, Ganz T, Zaritsky J. Increased serum hepcidin contributes to the anemia of chronic kidney disease in a murine model. Haematologica. PMID 27884972 DOI: 10.3324/Haematol.2016.150433  0.554
2016 Ganz T. Macrophages and Iron Metabolism. Microbiology Spectrum. 4. PMID 27763254 DOI: 10.1128/Microbiolspec.Mchd-0037-2016  0.604
2016 Hanudel MR, Chua K, Rappaport M, Gabayan V, Valore E, Goltzman D, Ganz T, Nemeth E, Salusky IB. Effects of Dietary Iron Intake and Chronic Kidney Disease on Fibroblast Growth Factor 23 Metabolism in Wild Type and Hepcidin Knockout Mice. American Journal of Physiology. Renal Physiology. ajprenal.00281.2016. PMID 27733366 DOI: 10.1152/Ajprenal.00281.2016  0.686
2016 Ganz T. Hepcidin. [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology. 57: 1913-1917. PMID 27725588 DOI: 10.11406/rinketsu.57.1913  0.561
2016 Latour C, Wlodarczyk MF, Jung G, Gineste A, Blanchard N, Ganz T, Roth MP, Coppin H, Kautz L. Erythroferrone contributes to hepcidin repression in a mouse model of malarial anemia. Haematologica. PMID 27658439 DOI: 10.3324/Haematol.2016.150227  0.478
2016 Ganz T, Nemeth E. Iron Balance and the Role of Hepcidin in Chronic Kidney Disease. Seminars in Nephrology. 36: 87-93. PMID 27236128 DOI: 10.1016/J.Semnephrol.2016.02.001  0.707
2016 Casu C, Oikonomidou PR, Chen H, Nandi V, Ginzburg Y, Prasad P, Fleming RE, Shah YM, Valore EV, Nemeth E, Ganz T, MacDonald B, Rivella S. Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera. Blood. PMID 27154187 DOI: 10.1182/Blood-2015-10-676742  0.672
2016 Kalinowski DS, Stefani C, Toyokuni S, Ganz T, Anderson GJ, Subramaniam NV, Trinder D, Olynyk JK, Chua A, Jansson PJ, Sahni S, Lane DJ, Merlot AM, Kovacevic Z, Huang ML, et al. Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics. Biochimica Et Biophysica Acta. PMID 26844773 DOI: 10.1016/J.Bbamcr.2016.01.026  0.41
2016 Kim A, Fung E, Parikh SG, Gabayan V, Nemeth E, Ganz T. Isocitrate treatment of acute anemia of inflammation in a mouse model. Blood Cells, Molecules & Diseases. 56: 31-6. PMID 26603720 DOI: 10.1016/J.Bcmd.2015.09.007  0.742
2016 Kautz L, Aschemeyer S, Gabayan V, Ganz T, Nemeth E. Erythroferrone Regulates Hepcidin Expression Independently of Matriptase 2 Blood. 128: 3616-3616. DOI: 10.1182/Blood.V128.22.3616.3616  0.687
2016 Stefanova D, Arezes J, Michels K, Dillon B, Horwitz M, Mehrad B, Bulut Y, Ganz T, Nemeth E. Hepcidin Protects Against Extracellular Infections By Eliminating Non-Transferrin-Bound Iron Blood. 128: 260-260. DOI: 10.1182/Blood.V128.22.260.260  0.699
2015 Drakesmith H, Nemeth E, Ganz T. Ironing out Ferroportin. Cell Metabolism. 22: 777-87. PMID 26437604 DOI: 10.1016/J.Cmet.2015.09.006  0.704
2015 Michels K, Nemeth E, Ganz T, Mehrad B. Hepcidin and Host Defense against Infectious Diseases. Plos Pathogens. 11: e1004998. PMID 26291319 DOI: 10.1371/Journal.Ppat.1004998  0.701
2015 Kautz L, Jung G, Du X, Gabayan V, Chapman J, Nasoff M, Nemeth E, Ganz T. Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia. Blood. PMID 26276665 DOI: 10.1182/Blood-2015-07-658419  0.679
2015 Ganz T, Nemeth E. Iron homeostasis in host defence and inflammation. Nature Reviews. Immunology. 15: 500-10. PMID 26160612 DOI: 10.1038/Nri3863  0.701
2015 Chua K, Fung E, Micewicz ED, Ganz T, Nemeth E, Ruchala P. Small cyclic agonists of iron regulatory hormone hepcidin. Bioorganic & Medicinal Chemistry Letters. PMID 25813158 DOI: 10.1016/J.Bmcl.2015.03.012  0.62
2015 Keel SB, Doty R, Liu L, Nemeth E, Cherian S, Ganz T, Abkowitz JL. Evidence that the expression of transferrin receptor 1 on erythroid marrow cells mediates hepcidin suppression in the liver. Experimental Hematology. 43: 469-478.e6. PMID 25782630 DOI: 10.1016/J.Exphem.2015.03.001  0.637
2015 Fung E, Chua K, Ganz T, Nemeth E, Ruchala P. Thiol-derivatized minihepcidins retain biological activity. Bioorganic & Medicinal Chemistry Letters. 25: 763-6. PMID 25599838 DOI: 10.1016/J.Bmcl.2014.12.094  0.574
2015 Arezes J, Jung G, Gabayan V, Valore E, Ruchala P, Gulig PA, Ganz T, Nemeth E, Bulut Y. Hepcidin-induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificus. Cell Host & Microbe. 17: 47-57. PMID 25590758 DOI: 10.1016/J.Chom.2014.12.001  0.682
2015 Ganz T. Hepcidin and the global burden of iron deficiency. Clinical Chemistry. 61: 577-8. PMID 25492087 DOI: 10.1373/Clinchem.2014.229179  0.582
2015 Gutschow P, Schmidt PJ, Han H, Ostland V, Bartnikas TB, Pettiglio MA, Herrera C, Butler JS, Nemeth E, Ganz T, Fleming MD, Westerman M. A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis. Haematologica. 100: 167-77. PMID 25425686 DOI: 10.3324/Haematol.2014.116723  0.711
2015 Macciò A, Madeddu C, Gramignano G, Mulas C, Tanca L, Cherchi MC, Floris C, Omoto I, Barracca A, Ganz T. The role of inflammation, iron, and nutritional status in cancer-related anemia: results of a large, prospective, observational study. Haematologica. 100: 124-32. PMID 25239265 DOI: 10.3324/Haematol.2014.112813  0.438
2015 Shawki A, Ruwe TA, Mitchell C, Prakash S, Nemeth E, Ganz T, Mackenzie B. Ferroportin-mediated cellular iron efflux requires extracellular calcium The Faseb Journal. 29. DOI: 10.1096/Fasebj.29.1_Supplement.566.15  0.685
2014 Kautz L, Jung G, Nemeth E, Ganz T. Erythroferrone contributes to recovery from anemia of inflammation. Blood. 124: 2569-74. PMID 25193872 DOI: 10.1182/Blood-2014-06-584607  0.698
2014 Zhang S, Chen Y, Guo W, Yuan L, Zhang D, Xu Y, Nemeth E, Ganz T, Liu S. Disordered hepcidin-ferroportin signaling promotes breast cancer growth. Cellular Signalling. 26: 2539-50. PMID 25093806 DOI: 10.1016/J.Cellsig.2014.07.029  0.624
2014 Nemeth E, Ganz T. Anemia of inflammation. Hematology/Oncology Clinics of North America. 28: 671-81, vi. PMID 25064707 DOI: 10.1016/J.Hoc.2014.04.005  0.682
2014 Domenico ID, Nemeth E, Nelson JM, Phillips JD, Ajioka RS, Kay MS, Kushner JP, Ganz T, Ward DM, Kaplan J. Retraction notice to: The hepcidin-binding site on ferroportin is evolutionarily conserved. Cell Metabolism. 19: 1067-1067. PMID 25025111 DOI: 10.1016/J.Cmet.2014.05.010  0.504
2014 Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nature Genetics. 46: 678-84. PMID 24880340 DOI: 10.1038/Ng.2996  0.705
2014 Kim A, Rivera S, Shprung D, Limbrick D, Gabayan V, Nemeth E, Ganz T. Mouse models of anemia of cancer. Plos One. 9: e93283. PMID 24681760 DOI: 10.1371/Journal.Pone.0093283  0.778
2014 Rodriguez R, Jung CL, Gabayan V, Deng JC, Ganz T, Nemeth E, Bulut Y. Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6. Infection and Immunity. 82: 745-52. PMID 24478088 DOI: 10.1128/Iai.00983-13  0.606
2014 Kim A, Fung E, Parikh SG, Valore EV, Gabayan V, Nemeth E, Ganz T. A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin. Blood. 123: 1129-36. PMID 24357728 DOI: 10.1182/Blood-2013-08-521419  0.791
2014 Mitchell CJ, Shawki A, Ganz T, Nemeth E, Mackenzie B. Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc. American Journal of Physiology. Cell Physiology. 306: C450-9. PMID 24304836 DOI: 10.1152/Ajpcell.00348.2013  0.687
2014 Latour C, Kautz L, Besson-Fournier C, Island ML, Canonne-Hergaux F, Loréal O, Ganz T, Coppin H, Roth MP. Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin. Hepatology (Baltimore, Md.). 59: 683-94. PMID 23907767 DOI: 10.1002/Hep.26648  0.507
2014 Nemeth E, Ganz T, Kautz L. Erythron to the Liver: Send Iron Blood. 124: SCI-37-SCI-37. DOI: 10.1182/Blood.V124.21.Sci-37.Sci-37  0.712
2014 Casu C, Oikonomidau R, Shah Y, Nemeth E, Ganz T, MacDonald B, Rivella S. Concurrent Treatment with Minhepcidin and Deferiprone Improves Anemia and Enhances Reduction of Spleen Iron in a Mouse Model of Non-Transfusion Dependent Thalassemia Blood. 124: 748-748. DOI: 10.1182/Blood.V124.21.748.748  0.704
2014 Kautz L, Latour C, Myriam W, Blanchard N, Ganz T, Roth MP, Coppin H. Erythroferrone Represses Hepcidin Expression in a Mouse Model of Malaria Blood. 124: 4022-4022. DOI: 10.1182/Blood.V124.21.4022.4022  0.503
2014 Casu C, Oikonomidau R, Nemeth E, Ganz T, MacDonald B, Rivella S. Use of Minihepcidins As a “Medical Phlebotomy” in the Treatment of Polycythemia Vera Blood. 124: 3231-3231. DOI: 10.1182/Blood.V124.21.3231.3231  0.672
2014 Kautz L, Jung G, Nemeth E, Ganz T. Role of Erythroferrone in the Pathophysiology of Common Anemias Blood. 124: 213-213. DOI: 10.1182/Blood.V124.21.213.213  0.664
2014 Parikh S, Fung E, Nemeth E, Ganz T, Kim A. Isocitrate Reverses Anemia of Inflammation in a Mouse Model Treated with Heat-Killed Brucella Abortus Blood. 124: 1349-1349. DOI: 10.1182/Blood.V124.21.1349.1349  0.744
2014 Ross D, Ardehali A, Belperio J, Derhovanessian A, Weigt S, Sayah D, Lynch J, Saggar R, Shino M, Jacquet M, Kubak B, Ganz T. Serum Hepcidin Antimicrobial Peptide Levels Predict Infection After Lung Transplantation The Journal of Heart and Lung Transplantation. 33: S289. DOI: 10.1016/J.Healun.2014.01.773  0.374
2013 Kautz L, Gabayan V, Wang X, Wu J, Onwuzurike J, Jung G, Qiao B, Lusis AJ, Ganz T, Nemeth E. Testing the iron hypothesis in a mouse model of atherosclerosis. Cell Reports. 5: 1436-42. PMID 24316081 DOI: 10.1016/J.Celrep.2013.11.009  0.706
2013 Ganz T. Systemic iron homeostasis. Physiological Reviews. 93: 1721-41. PMID 24137020 DOI: 10.1152/Physrev.00008.2013  0.615
2013 McCranor BJ, Langdon JM, Prince OD, Femnou LK, Berger AE, Cheadle C, Civin CI, Kim A, Rivera S, Ganz T, Vaulont S, Xue QL, Walston JD, Roy CN. Investigation of the role of interleukin-6 and hepcidin antimicrobial peptide in the development of anemia with age. Haematologica. 98: 1633-40. PMID 23996485 DOI: 10.3324/Haematol.2013.087114  0.767
2013 Clark RJ, Preza GC, Tan CC, van Dijk JW, Fung E, Nemeth E, Ganz T, Craik DJ. Design, synthesis, and characterization of cyclic analogues of the iron regulatory peptide hormone hepcidin. Biopolymers. 100: 519-26. PMID 23897622 DOI: 10.1002/Bip.22350  0.833
2013 Ganz T. Preface: iron and cancer. Critical Reviews in Oncogenesis. 18: preceding 391. PMID 23879592 DOI: 10.1615/Critrevoncog.2013007770  0.538
2013 Preza GC, Pinon R, Ganz T, Nemeth E. Cellular catabolism of the iron-regulatory peptide hormone hepcidin. Plos One. 8: e58934. PMID 23536837 DOI: 10.1371/Journal.Pone.0058934  0.836
2013 Mast AE, Schlumpf KS, Wright DJ, Johnson B, Glynn SA, Busch MP, Olbina G, Westerman M, Nemeth E, Ganz T. Hepcidin level predicts hemoglobin concentration in individuals undergoing repeated phlebotomy. Haematologica. 98: 1324-30. PMID 23445875 DOI: 10.3324/Haematol.2012.070979  0.669
2013 Fung E, Sugianto P, Hsu J, Damoiseaux R, Ganz T, Nemeth E. High-throughput screening of small molecules identifies hepcidin antagonists. Molecular Pharmacology. 83: 681-90. PMID 23292796 DOI: 10.1124/Mol.112.083428  0.678
2013 Casu C, Goldberg A, Nemeth E, Ganz T, Gardenghi S, MacDonald B, Rivella S. Treatment With Minihepcidin Peptide Improves Anemia and Iron Overload In a Mouse Model Of Thalassemia Intermedia Blood. 122: 431-431. DOI: 10.1182/Blood.V122.21.431.431  0.71
2013 Kautz L, Jung G, Nemeth E, Ganz T. The Erythroid Factor Erythroferrone and Its Role In Iron Homeostasis Blood. 122: 4-4. DOI: 10.1182/Blood.V122.21.4.4  0.71
2013 Arezes J, Jung G, Gabayan V, Valore E, Ganz T, Bulut Y, Nemeth E. Hepcidin-Induced Hypoferremia Is a Host-Defense Mechanism Against Siderophilic Bacteria Blood. 122: 176-176. DOI: 10.1182/Blood.V122.21.176.176  0.696
2013 Condon F, Li H, Kessler D, Nandi V, Ganz T, Nemeth E, Westerman M, Shaz BH, Ginzburg Y. Evidence Of Relative Iron Deficiency in Apheresis Platelet Donors Correlates With Donation Frequency Blood. 122: 1155-1155. DOI: 10.1182/Blood.V122.21.1155.1155  0.631
2012 Ganz T, Goff J, Klasing K, Nemeth E, Roth T. IOD in rhinos--immunity group report: report from the Immunity, Genetics and Toxicology Working Group of the International Workshop on Iron Overload Disorder in Browsing Rhinoceros (February 2011). Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians. 43: S117-9. PMID 23156715 DOI: 10.1638/1042-7260-43.3S.S117  0.587
2012 Ganz T, Nemeth E. Iron homeostasis and its disorders in mice and men: potential lessons for rhinos. Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians. 43: S19-26. PMID 23156702 DOI: 10.1638/2011-0158.1  0.69
2012 Ramos E, Ruchala P, Goodnough JB, Kautz L, Preza GC, Nemeth E, Ganz T. Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis. Blood. 120: 3829-36. PMID 22990014 DOI: 10.1182/Blood-2012-07-440743  0.847
2012 Qiao B, Sugianto P, Fung E, Del-Castillo-Rueda A, Moran-Jimenez MJ, Ganz T, Nemeth E. Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination. Cell Metabolism. 15: 918-24. PMID 22682227 DOI: 10.1016/J.Cmet.2012.03.018  0.706
2012 Ross SL, Tran L, Winters A, Lee KJ, Plewa C, Foltz I, King C, Miranda LP, Allen J, Beckman H, Cooke KS, Moody G, Sasu BJ, Nemeth E, Ganz T, et al. Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT. Cell Metabolism. 15: 905-17. PMID 22682226 DOI: 10.1016/J.Cmet.2012.03.017  0.61
2012 Besson-Fournier C, Latour C, Kautz L, Bertrand J, Ganz T, Roth MP, Coppin H. Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. Blood. 120: 431-9. PMID 22611157 DOI: 10.1182/Blood-2012-02-411470  0.497
2012 Ravasi G, Pelucchi S, Trombini P, Mariani R, Tomosugi N, Modignani GL, Pozzi M, Nemeth E, Ganz T, Hayashi H, Barisani D, Piperno A. Hepcidin expression in iron overload diseases is variably modulated by circulating factors. Plos One. 7: e36425. PMID 22586470 DOI: 10.1371/Journal.Pone.0036425  0.669
2012 Ganz T, Nemeth E. Iron metabolism: interactions with normal and disordered erythropoiesis. Cold Spring Harbor Perspectives in Medicine. 2: a011668. PMID 22553501 DOI: 10.1101/Cshperspect.A011668  0.682
2012 Ganz T. Macrophages and systemic iron homeostasis. Journal of Innate Immunity. 4: 446-53. PMID 22441209 DOI: 10.1159/000336423  0.614
2012 Ganz T, Nemeth E. Hepcidin and iron homeostasis. Biochimica Et Biophysica Acta. 1823: 1434-43. PMID 22306005 DOI: 10.1016/J.Bbamcr.2012.01.014  0.716
2012 Goodnough JB, Ramos E, Nemeth E, Ganz T. Inhibition of hepcidin transcription by growth factors. Hepatology (Baltimore, Md.). 56: 291-9. PMID 22278715 DOI: 10.1002/Hep.25615  0.796
2012 Ganz T. The role of antimicrobial peptides in innate immunity. Integrative and Comparative Biology. 43: 300-4. PMID 21680437 DOI: 10.1093/icb/43.2.300  0.313
2012 Ganz T, Madera L, Hancock REW, Suzuki T, Yamamoto N, Watanabe M, Takaku H, Chang MO, Cortez-Retamozo V, Etzrodt M, Pittet MJ, Anders H, Weidenbusch M, Gordon S, Fisher EA, et al. Contents Vol. 4, 2012 Journal of Innate Immunity. 4. DOI: 10.1159/000341372  0.28
2012 Ganz T, Köhler W, Pervak V, Baum P. Few-cycle high energy pulse compression at MHz repetition rate Proceedings of Spie - the International Society For Optical Engineering. 8240. DOI: 10.1117/12.906757  0.171
2012 McMurray JJV, Parfrey PS, Adamson JW, Aljama P, Berns JS, Bohlius J, Drüeke TB, Finkelstein FO, Fishbane S, Ganz T, MacDougall IC, McDonald RA, McMahon LP, Obrador GT, Strippoli GFM, et al. Kidney disease: Improving global outcomes (KDIGO) anemia work group. KDIGO clinical practice guideline for anemia in chronic kidney disease Kidney International Supplements. 2: 279-335. DOI: 10.1038/Kisup.2012.37  0.396
2011 Ganz T, Nemeth E. The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2011: 538-42. PMID 22160086 DOI: 10.1182/Asheducation-2011.1.538  0.688
2011 Preza GC, Ruchala P, Pinon R, Ramos E, Qiao B, Peralta MA, Sharma S, Waring A, Ganz T, Nemeth E. Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload. The Journal of Clinical Investigation. 121: 4880-8. PMID 22045566 DOI: 10.1172/Jci57693  0.857
2011 Gordeuk VR, Miasnikova GY, Sergueeva AI, Niu X, Nouraie M, Okhotin DJ, Polyakova LA, Ammosova T, Nekhai S, Ganz T, Prchal JT. Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression. Blood. 118: 5278-82. PMID 21876117 DOI: 10.1182/Blood-2011-03-345512  0.465
2011 Trombini P, Paolini V, Pelucchi S, Mariani R, Nemeth E, Ganz T, Piperno A. Hepcidin response to acute iron intake and chronic iron loading in dysmetabolic iron overload syndrome. Liver International : Official Journal of the International Association For the Study of the Liver. 31: 994-1000. PMID 21733088 DOI: 10.1111/J.1478-3231.2011.02520.X  0.713
2011 Miasnikova GY, Sergueeva AI, Nouraie M, Niu X, Okhotin DJ, Polyakova LA, Ganz T, Prchal JT, Gordeuk VR. The heterozygote advantage of the Chuvash polycythemia VHLR200W mutation may be protection against anemia. Haematologica. 96: 1371-4. PMID 21606165 DOI: 10.3324/Haematol.2011.045609  0.369
2011 Pasricha SR, McQuilten Z, Westerman M, Keller A, Nemeth E, Ganz T, Wood E. Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors. Haematologica. 96: 1099-105. PMID 21508121 DOI: 10.3324/Haematol.2010.037960  0.698
2011 Ramos E, Kautz L, Rodriguez R, Hansen M, Gabayan V, Ginzburg Y, Roth MP, Nemeth E, Ganz T. Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology (Baltimore, Md.). 53: 1333-41. PMID 21480335 DOI: 10.1002/Hep.24178  0.707
2011 Clark RJ, Tan CC, Preza GC, Nemeth E, Ganz T, Craik DJ. Understanding the structure/activity relationships of the iron regulatory peptide hepcidin. Chemistry & Biology. 18: 336-43. PMID 21439478 DOI: 10.1002/Psc.2448  0.85
2011 Ganz T. Hepcidin and iron regulation, 10 years later. Blood. 117: 4425-33. PMID 21346250 DOI: 10.1182/Blood-2011-01-258467  0.616
2011 Ghoti H, Fibach E, Westerman M, Gordana O, Ganz T, Rachmilewitz EA. Increased serum hepcidin levels during treatment with deferasirox in iron-overloaded patients with myelodysplastic syndrome. British Journal of Haematology. 153: 118-20. PMID 21332711 DOI: 10.1111/J.1365-2141.2011.08587.X  0.589
2011 Girelli D, Trombini P, Busti F, Campostrini N, Sandri M, Pelucchi S, Westerman M, Ganz T, Nemeth E, Piperno A, Camaschella C. A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis. Haematologica. 96: 500-6. PMID 21173098 DOI: 10.3324/Haematol.2010.033449  0.707
2011 Piperno A, Galimberti S, Mariani R, Pelucchi S, Ravasi G, Lombardi C, Bilo G, Revera M, Giuliano A, Faini A, Mainini V, Westerman M, Ganz T, Valsecchi MG, Mancia G, et al. Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project. Blood. 117: 2953-9. PMID 21149632 DOI: 10.1182/Blood-2010-08-299859  0.58
2011 Ganz T, Nemeth E. Hepcidin and disorders of iron metabolism. Annual Review of Medicine. 62: 347-60. PMID 20887198 DOI: 10.1146/Annurev-Med-050109-142444  0.71
2011 Nemeth E, Ramos E, Ruchala P, Preza G, Ganz T. Mini-Hepcidins Prevent Iron Overload In A Mouse Model of Hereditary Hemochromatosis Blood. 118: 689-689. DOI: 10.1182/Blood.V118.21.689.689  0.856
2011 Wang S, Li H, Sarran L, Olbina G, Westerman M, Nemeth E, Bouhassira EE, Ganz T, Ginzburg Y. Hepcidin in Male Double Red Blood Cell Donors - Relationship Between Parameters of Iron Metabolism and Erythropoiesis Blood. 118: 2109-2109. DOI: 10.1182/Blood.V118.21.2109.2109  0.671
2011 Hösel T, Cvancara P, Ganz T, Müller C, Reinecke H. Characterisation of high aspect ratio non-conductive ceramic microstructures made by spark erosion Microsystem Technologies. 17: 313-318. DOI: 10.1007/s00542-011-1284-0  0.199
2011 Čvančara P, Ganz T, Hösel T, Müller C, Reinecke H. Precise manufacturing of micro structures by spark erosion in electrically non-conductive zirconia Proceedings of the 11th International Conference of the European Society For Precision Engineering and Nanotechnology, Euspen 2011. 2: 439-442.  0.19
2010 Goodnough LT, Nemeth E, Ganz T. Detection, evaluation, and management of iron-restricted erythropoiesis. Blood. 116: 4754-61. PMID 20826717 DOI: 10.1182/Blood-2010-05-286260  0.688
2010 Maes K, Nemeth E, Roodman GD, Huston A, Esteve F, Freytes C, Callander N, Katodritou E, Tussing-Humphreys L, Rivera S, Vanderkerken K, Lichtenstein A, Ganz T. In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2. Blood. 116: 3635-44. PMID 20679527 DOI: 10.1182/Blood-2010-03-274571  0.719
2010 Bachman E, Feng R, Travison T, Li M, Olbina G, Ostland V, Ulloor J, Zhang A, Basaria S, Ganz T, Westerman M, Bhasin S. Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis. The Journal of Clinical Endocrinology and Metabolism. 95: 4743-7. PMID 20660052 DOI: 10.1210/Jc.2010-0864  0.415
2010 Chen Q, Hakimi M, Wu S, Jin Y, Cheng B, Wang H, Xie G, Ganz T, Linzmeier RM, Fang X. Increased genomic copy number of DEFA1/DEFA3 is associated with susceptibility to severe sepsis in Chinese Han population. Anesthesiology. 112: 1428-34. PMID 20502117 DOI: 10.1097/Aln.0B013E3181D968Eb  0.401
2010 Ayoya MA, Spiekermann-Brouwer GM, Stoltzfus RJ, Nemeth E, Habicht JP, Ganz T, Rawat R, Traoré AK, Garza C. Alpha 1-acid glycoprotein, hepcidin, C-reactive protein, and serum ferritin are correlated in anemic schoolchildren with Schistosoma haematobium. The American Journal of Clinical Nutrition. 91: 1784-90. PMID 20410090 DOI: 10.3945/Ajcn.2010.29353  0.622
2010 Zaritsky J, Young B, Gales B, Wang HJ, Rastogi A, Westerman M, Nemeth E, Ganz T, Salusky IB. Reduction of serum hepcidin by hemodialysis in pediatric and adult patients. Clinical Journal of the American Society of Nephrology : Cjasn. 5: 1010-4. PMID 20299375 DOI: 10.2215/Cjn.08161109  0.639
2010 Bdeir K, Higazi AA, Kulikovskaya I, Christofidou-Solomidou M, Vinogradov SA, Allen TC, Idell S, Linzmeier R, Ganz T, Cines DB. Neutrophil alpha-defensins cause lung injury by disrupting the capillary-epithelial barrier. American Journal of Respiratory and Critical Care Medicine. 181: 935-46. PMID 20093642 DOI: 10.1164/Rccm.200907-1128Oc  0.36
2010 Ferrucci L, Semba RD, Guralnik JM, Ershler WB, Bandinelli S, Patel KV, Sun K, Woodman RC, Andrews NC, Cotter RJ, Ganz T, Nemeth E, Longo DL. Proinflammatory state, hepcidin, and anemia in older persons. Blood. 115: 3810-6. PMID 20081092 DOI: 10.1182/Blood-2009-02-201087  0.679
2010 Pasricha SS, McQuilten Z, Westerman M, Keller A, Nemeth E, Ganz T, Wood EM. Is Serum Hepcidin a Useful Diagnostic Test for Iron Deficiency? Blood. 116: 2056-2056. DOI: 10.1182/Blood.V116.21.2056.2056  0.688
2010 Rivera S, Vaulont S, Shprung D, Limbrick D, Ganz T. Hepcidin Independent Anemia of Inflammation Blood. 116: 2050-2050. DOI: 10.1182/Blood.V116.21.2050.2050  0.735
2010 Kim A, Gabayan V, Dorigo O, Ganz T, Rivera S. Two Mouse Models Illustrate Different Mechanisms of Anemia of Cancer Blood. 116: 2034-2034. DOI: 10.1182/Blood.V116.21.2034.2034  0.773
2010 Pasricha SS, McQuilten Z, Westerman M, Keller A, Nemeth E, Ganz T, Wood EM. Iron Deficiency without Anemia In Premenopausal Blood Donors Is Associated with Future Deferral From Whole Blood Donation. Blood. 116: 1110-1110. DOI: 10.1182/Blood.V116.21.1110.1110  0.666
2010 Westerman ME, Olbina G, Ostland VE, Nemeth E, Ganz T. Hepcidin: An emerging biomarker for iron disorders, inflammatory diseases, and infections Proceedings of Spie - the International Society For Optical Engineering. 7666. DOI: 10.1117/12.854910  0.734
2010 Piperno A, Pelucchi S, Mariani R, Nemeth E, Ganz T, Mainini V, Bilo G, Revera M, Savia G, Giuliano A, Faini A, Agostoni P, Mancia G, Parati G. The Iron-Hypoxia Link: Hepcidin Has A Central Role In The Response To Acute And Chronic Exposure To Hypobaric Hypoxia. Data From The Highcare Project: Pp.12.453 Journal of Hypertension. 28. DOI: 10.1097/01.Hjh.0000378778.87121.6B  0.475
2010 Trombini P, Busti F, Campostrini N, Sandri M, Pelucchi S, Nemeth E, Ganz T, Camaschella C, Girelli D, Piperno A. 1 TIME COURSE OF HEPCIDIN RESPONSE TO ORAL IRON TEST CLARIFIES THE ROLE OF HFE AND TFR2 IN IRON SENSING Digestive and Liver Disease. 42: S1. DOI: 10.1016/S1590-8658(10)00093-9  0.686
2010 Trombini P, Busti F, Campostrini N, Sandri M, Pelucchi S, Nemeth E, Ganz T, Camaschella C, Girelli D, Piperno A. 1133 A TIME COURSE OF HEPCIDIN RESPONSE TO ORAL IRON CHALLENGE IN HFE AND TFR2 HEMOCHROMATOSIS PATIENTS Journal of Hepatology. 52: S437. DOI: 10.1016/S0168-8278(10)61134-8  0.707
2010 Andrews NC, Ganz T. The Molecular Basis of Iron Metabolism Molecular Hematology: Third Edition. 169-178. DOI: 10.1002/9781444318531.ch14  0.457
2010 Ganz T. Anemia of Chronic Disease Molecular Hematology: Third Edition. 165-168. DOI: 10.1002/9781444318531.ch13  0.246
2010 Lehrer RI, Ganz T. Antimicrobial Peptides: Defensins and Cathelicidins Topley and Wilson's Microbiology and Microbial Infections. DOI: 10.1002/9780470688618.Taw0091  0.398
2009 Kroot JJ, Kemna EH, Bansal SS, Busbridge M, Campostrini N, Girelli D, Hider RC, Koliaraki V, Mamalaki A, Olbina G, Tomosugi N, Tselepis C, Ward DG, Ganz T, Hendriks JC, et al. Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization. Haematologica. 94: 1748-52. PMID 19996119 DOI: 10.3324/Haematol.2009.010322  0.444
2009 Nemeth E, Ganz T. The role of hepcidin in iron metabolism. Acta Haematologica. 122: 78-86. PMID 19907144 DOI: 10.1159/000243791  0.707
2009 Ganz T, Nemeth E. Iron sequestration and anemia of inflammation. Seminars in Hematology. 46: 387-93. PMID 19786207 DOI: 10.1053/J.Seminhematol.2009.06.001  0.711
2009 Rivera S, Ganz T. Animal models of anemia of inflammation. Seminars in Hematology. 46: 351-7. PMID 19786203 DOI: 10.1053/J.Seminhematol.2009.06.003  0.667
2009 Girelli D, Pasino M, Goodnough JB, Nemeth E, Guido M, Castagna A, Busti F, Campostrini N, Martinelli N, Vantini I, Corrocher R, Ganz T, Fattovich G. Reduced serum hepcidin levels in patients with chronic hepatitis C. Journal of Hepatology. 51: 845-52. PMID 19729219 DOI: 10.1016/J.Jhep.2009.06.027  0.846
2009 Sham RL, Phatak PD, Nemeth E, Ganz T. Hereditary hemochromatosis due to resistance to hepcidin: high hepcidin concentrations in a family with C326S ferroportin mutation. Blood. 114: 493-4. PMID 19589941 DOI: 10.1182/Blood-2009-04-216226  0.691
2009 Katodritou E, Ganz T, Terpos E, Verrou E, Olbina G, Gastari V, Hadjiaggelidou C, Varthaliti M, Georgiadou S, Westerman M, Zervas K. Sequential evaluation of serum hepcidin in anemic myeloma patients: study of correlations with myeloma treatment, disease variables, and anemia response. American Journal of Hematology. 84: 524-6. PMID 19536845 DOI: 10.1002/Ajh.21448  0.447
2009 Tanno T, Porayette P, Sripichai O, Noh SJ, Byrnes C, Bhupatiraju A, Lee YT, Goodnough JB, Harandi O, Ganz T, Paulson RF, Miller JL. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood. 114: 181-6. PMID 19414861 DOI: 10.1182/Blood-2008-12-195503  0.814
2009 Zaritsky J, Young B, Wang HJ, Westerman M, Olbina G, Nemeth E, Ganz T, Rivera S, Nissenson AR, Salusky IB. Hepcidin--a potential novel biomarker for iron status in chronic kidney disease. Clinical Journal of the American Society of Nephrology : Cjasn. 4: 1051-6. PMID 19406957 DOI: 10.2215/Cjn.05931108  0.767
2009 Ruivard M, Lainé F, Ganz T, Olbina G, Westerman M, Nemeth E, Rambeau M, Mazur A, Gerbaud L, Tournilhac V, Abergel A, Philippe P, Deugnier Y, Coudray C. Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin. Journal of Hepatology. 50: 1219-25. PMID 19398238 DOI: 10.1016/J.Jhep.2009.01.029  0.683
2009 Fernandes A, Preza GC, Phung Y, De Domenico I, Kaplan J, Ganz T, Nemeth E. The molecular basis of hepcidin-resistant hereditary hemochromatosis. Blood. 114: 437-43. PMID 19383972 DOI: 10.1182/Blood-2008-03-146134  0.836
2009 Troadec MB, Lainé F, Daniel V, Rochcongar P, Ropert M, Cabillic F, Perrin M, Morcet J, Loréal O, Olbina G, Westerman M, Nemeth E, Ganz T, Brissot P. Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism. European Journal of Applied Physiology. 106: 435-43. PMID 19306018 DOI: 10.1007/S00421-009-1031-8  0.635
2009 Ganz T. Iron in innate immunity: starve the invaders. Current Opinion in Immunology. 21: 63-7. PMID 19231148 DOI: 10.1016/J.Coi.2009.01.011  0.59
2009 Wilson CL, Schmidt AP, Pirilä E, Valore EV, Ferri N, Sorsa T, Ganz T, Parks WC. Differential Processing of {alpha}- and {beta}-Defensin Precursors by Matrix Metalloproteinase-7 (MMP-7). The Journal of Biological Chemistry. 284: 8301-11. PMID 19181662 DOI: 10.1074/Jbc.M809744200  0.365
2009 Maes K, Huston A, Roodman D, Rivera S, Nemeth E, Lichtenstein A, Vanderkerken K, Ganz T. Characterization of Hepcidin-Inducing Cytokines in Multiple Myeloma. Blood. 114: 2001-2001. DOI: 10.1182/Blood.V114.22.2001.2001  0.72
2009 Bourikas L, Enayati P, Shaye O, Nemeth E, Ganz T, Papadakis K. P028 - The role of hepcidin in Crohn's disease associated anemia Journal of Crohn's and Colitis. 3: S22. DOI: 10.1016/S1873-9946(09)60055-6  0.48
2009 Paolini V, Trombini P, Pelucchi S, Mariani R, Salvioni A, Pozzi M, Nemeth E, Ganz T, Piperno A. 1015 DYSMETABOLIC HEPATIC IRON OVERLOAD SYNDROME: ANALYSIS OF HEPCIDIN RESPONSE TO ACUTE ORAL IRON AND CHRONIC IRON OVERLOAD Journal of Hepatology. 50: S367-S368. DOI: 10.1016/S0168-8278(09)61017-5  0.69
2009 Ghoti H, Fibach E, Merkel D, Amer J, Nagler A, Perez-Avraham G, Grisariu S, Naparstek E, Ackerstein A, Olbina G, Westerman M, Ganz T, Rachmilewitz E. P105 Decrease in intra- and extra-cellular free iron species and oxidative stress parameters and increase in serum and urinary hepcidin during treatment with deferasirox in iron-loaded patients with MDS Leukemia Research. 33: S120-S121. DOI: 10.1016/S0145-2126(09)70186-9  0.541
2009 Bourikas LA, Enayati P, Shaye O, Nemeth E, Ganz T, Papadakis KA. S1109 The Role of Hepcidin in Crohn's Disease (CD)-Associated Anemia Gastroenterology. 136: A-190-A-191. DOI: 10.1016/S0016-5085(09)60858-1  0.513
2009 Kim A, Ganz T, Rivera S. THE ROLE OF BONE MORPHOGENETIC PROTEIN 6 IN THE ANEMIA OF LUNG CANCER Chest. 136: 20S. DOI: 10.1016/S0012-3692(16)47768-8  0.709
2008 Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M. Immunoassay for human serum hepcidin. Blood. 112: 4292-7. PMID 18689548 DOI: 10.1182/Blood-2008-02-139915  0.622
2008 De Domenico I, Nemeth E, Nelson JM, Phillips JD, Ajioka RS, Kay MS, Kushner JP, Ganz T, Ward DM, Kaplan J. The hepcidin-binding site on ferroportin is evolutionarily conserved. Cell Metabolism. 8: 146-56. PMID 18680715 DOI: 10.1016/J.Cmet.2008.07.002  0.632
2008 Sharma S, Nemeth E, Chen YH, Goodnough J, Huston A, Roodman GD, Ganz T, Lichtenstein A. Involvement of hepcidin in the anemia of multiple myeloma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 3262-7. PMID 18519751 DOI: 10.1158/1078-0432.Ccr-07-4153  0.788
2008 Winder A, Lefkowitz R, Ghoti H, Leiba M, Ganz T, Nemeth E, Rachmilewitz EA. Urinary hepcidin excretion in patients with myelodysplastic syndrome and myelofibrosis. British Journal of Haematology. 142: 669-71. PMID 18498424 DOI: 10.1111/J.1365-2141.2008.07225.X  0.51
2008 Barisani D, Pelucchi S, Mariani R, Galimberti S, Trombini P, Fumagalli D, Meneveri R, Nemeth E, Ganz T, Piperno A. Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload. Journal of Hepatology. 49: 123-33. PMID 18462824 DOI: 10.1016/J.Jhep.2008.03.011  0.703
2008 Ganz T. Iron homeostasis: fitting the puzzle pieces together. Cell Metabolism. 7: 288-90. PMID 18396134 DOI: 10.1016/J.Cmet.2008.03.008  0.6
2008 Bozzini C, Campostrini N, Trombini P, Nemeth E, Castagna A, Tenuti I, Corrocher R, Camaschella C, Ganz T, Olivieri O, Piperno A, Girelli D. Measurement of urinary hepcidin levels by SELDI-TOF-MS in HFE-hemochromatosis. Blood Cells, Molecules & Diseases. 40: 347-52. PMID 18164223 DOI: 10.1182/Blood.V110.11.2668.2668  0.582
2008 Aberg KM, Man MQ, Gallo RL, Ganz T, Crumrine D, Brown BE, Choi EH, Kim DK, Schröder JM, Feingold KR, Elias PM. Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. The Journal of Investigative Dermatology. 128: 917-25. PMID 17943185 DOI: 10.1038/Sj.Jid.5701099  0.393
2008 Valore EV, Ganz T. Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. Blood Cells, Molecules & Diseases. 40: 132-8. PMID 17905609 DOI: 10.1016/J.Bcmd.2007.07.009  0.473
2008 Lin L, Nemeth E, Goodnough JB, Thapa DR, Gabayan V, Ganz T. Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site. Blood Cells, Molecules & Diseases. 40: 122-31. PMID 17869549 DOI: 10.1016/J.Bcmd.2007.06.023  0.842
2008 Bullard RS, Gibson W, Bose SK, Belgrave JK, Eaddy AC, Wright CJ, Hazen-Martin DJ, Lage JM, Keane TE, Ganz TA, Donald CD. Functional analysis of the host defense peptide Human Beta Defensin-1: new insight into its potential role in cancer. Molecular Immunology. 45: 839-48. PMID 17868871 DOI: 10.1016/J.Molimm.2006.11.026  0.257
2008 Rivera S, Pastuszka M, Yu A, Gabayan V, Ganz T. HEPCIDIN MODULATION AS A TREATMENT FOR ANEMIA OF INFLAMMATION (AI) Chest. 134: 36P. DOI: 10.1378/Chest.134.4_Meetingabstracts.P36001  0.633
2008 Olbina G, Pastorino X, Girelli D, O’Brien KO, Nemeth E, Ganz T, Westerman M. Immunoassay for Human Hepcidin in Blood Blood. 112: 3839-3839. DOI: 10.1182/Blood.V112.11.3839.3839  0.677
2008 Rivera S, Kim A, Ganz T. The Role of Hepcidin in Anemia of Cancer Blood. 112: 3835-3835. DOI: 10.1182/Blood.V112.11.3835.3835  0.748
2008 Girelli D, Pasino M, Goodnough J, Nemeth E, Castagna A, Busti F, Campostrini N, Martinelli N, Guido M, Vantini I, Corrocher R, Ganz T, Fattovich G. Hepcidin Suppression Relative to Iron Status in Patients with Chronic Hepatitis C. Blood. 112: 1860-1860. DOI: 10.1182/Blood.V112.11.1860.1860  0.839
2008 Kroot JJ, Kemna EH, Bansal S, Busbridge M, Campostrini N, Girelli D, Hider RC, Koliaraki V, Mamalaki A, Olbina G, Tomosugi N, Tselepis C, Ward DG, Ganz T, Hendriks JC, et al. Results of the First International Round Robin for the Quantification of Urinary and Plasma Hepcidin: Need for Standardization Blood. 112: 120-120. DOI: 10.1182/Blood.V112.11.120.120  0.405
2008 Preza G, Fernandes A, Clark RJ, Craik DJ, Ganz T, Nemeth E. Structural Aspects of Hepcidin-Ferroportin Binding Blood. 112: 119-119. DOI: 10.1182/Blood.V112.11.119.119  0.83
2007 Aberg KM, Radek KA, Choi EH, Kim DK, Demerjian M, Hupe M, Kerbleski J, Gallo RL, Ganz T, Mauro T, Feingold KR, Elias PM. Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. The Journal of Clinical Investigation. 117: 3339-49. PMID 17975669 DOI: 10.1172/Jci31726  0.381
2007 Trombini P, Coliva T, Nemeth E, Mariani R, Ganz T, Biondi A, Piperno A. Effects of plasma transfusion on hepcidin production in human congenital hypotransferrinemia. Haematologica. 92: 1407-10. PMID 17768112 DOI: 10.3324/Haematol.11377  0.694
2007 Piperno A, Girelli D, Nemeth E, Trombini P, Bozzini C, Poggiali E, Phung Y, Ganz T, Camaschella C. Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis. Blood. 110: 4096-100. PMID 17724144 DOI: 10.1182/Blood-2007-06-096503  0.703
2007 Tanno T, Bhanu NV, Oneal PA, Goh SH, Staker P, Lee YT, Moroney JW, Reed CH, Luban NL, Wang RH, Eling TE, Childs R, Ganz T, Leitman SF, Fucharoen S, et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nature Medicine. 13: 1096-101. PMID 17721544 DOI: 10.1038/Nm1629  0.552
2007 Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood. 110: 2182-9. PMID 17540841 DOI: 10.1182/Blood-2007-04-087593  0.854
2007 Origa R, Galanello R, Ganz T, Giagu N, Maccioni L, Faa G, Nemeth E. Liver iron concentrations and urinary hepcidin in beta-thalassemia. Haematologica. 92: 583-8. PMID 17488680 DOI: 10.3324/Haematol.10842  0.715
2007 De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist WI, Ganz T, Musci G, Kaplan J. The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Molecular Biology of the Cell. 18: 2569-78. PMID 17475779 DOI: 10.1091/Mbc.E07-01-0060  0.628
2007 Ganz T. Molecular control of iron transport. Journal of the American Society of Nephrology : Jasn. 18: 394-400. PMID 17229910 DOI: 10.1681/Asn.2006070802  0.619
2007 Kearney SL, Nemeth E, Neufeld EJ, Thapa D, Ganz T, Weinstein DA, Cunningham MJ. Urinary hepcidin in congenital chronic anemias. Pediatric Blood & Cancer. 48: 57-63. PMID 16220548 DOI: 10.1002/Pbc.20616  0.696
2007 Rivera S, Gabayan V, Ganz T. INTERLEUKIN-6 INDEPENDENT REGULATION OF HEPCIDIN IN ANEMIA OF INFLAMMATION Chest. 132: 662A. DOI: 10.1378/Chest.132.4_Meetingabstracts.662A  0.675
2007 Rivera S, Gabayan V, Ganz T. IL-6 and Anemia of Inflammation. Blood. 110: 144-144. DOI: 10.1182/Blood.V110.11.144.144  0.678
2007 Nemeth E, Ganz T. Iron and aging Blood Disorders in the Elderly. 171-180. DOI: 10.1017/CBO9780511545238.014  0.623
2007 Winder A, Lefkowitz R, Ghoti H, Leiba M, Ganz T, Nemeth E, Rachmilewitz E. P034 Urinary hepcidin excretion in patients with myelodysplastic syndrome (MDS) and myelofibrosis (MF) Leukemia Research. 31: S59-S60. DOI: 10.1016/S0145-2126(07)70104-2  0.514
2006 Ganz T. Hepcidin and its role in regulating systemic iron metabolism. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 29-35, 507. PMID 17124036 DOI: 10.1182/Asheducation-2006.1.29  0.622
2006 Valore EV, Wiley DJ, Ganz T. Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis. Infection and Immunity. 74: 5693-702. PMID 16988245 DOI: 10.1128/Iai.00524-06  0.429
2006 Ganz T. Hepcidin - A peptide hormone at the interface of innate immunity and iron metabolism Current Topics in Microbiology and Immunology. 306: 183-198. PMID 16909922 DOI: 10.1007/3-540-29916-5_7  0.626
2006 De Domenico I, McVey Ward D, Nemeth E, Ganz T, Corradini E, Ferrara F, Musci G, Pietrangelo A, Kaplan J. Molecular and clinical correlates in iron overload associated with mutations in ferroportin. Haematologica. 91: 1092-5. PMID 16885049  0.622
2006 Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S. Suppression of hepcidin during anemia requires erythropoietic activity. Blood. 108: 3730-5. PMID 16882706 DOI: 10.1182/Blood-2006-06-028787  0.76
2006 Tan BH, Meinken C, Bastian M, Bruns H, Legaspi A, Ochoa MT, Krutzik SR, Bloom BR, Ganz T, Modlin RL, Stenger S. Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens. Journal of Immunology (Baltimore, Md. : 1950). 177: 1864-71. PMID 16849498 DOI: 10.4049/Jimmunol.177.3.1864  0.418
2006 Nemeth E, Ganz T. Regulation of iron metabolism by hepcidin. Annual Review of Nutrition. 26: 323-42. PMID 16848710 DOI: 10.1146/Annurev.Nutr.26.061505.111303  0.723
2006 Pospisilova D, Mims MP, Nemeth E, Ganz T, Prchal JT. DMT1 mutation: response of anemia to darbepoetin administration and implications for iron homeostasis. Blood. 108: 404-5. PMID 16790587 DOI: 10.1182/Blood-2006-02-003962  0.693
2006 Ganz T, Nemeth E. Regulation of iron acquisition and iron distribution in mammals. Biochimica Et Biophysica Acta. 1763: 690-9. PMID 16790283 DOI: 10.1016/J.Bbamcr.2006.03.014  0.718
2006 Sørensen OE, Thapa DR, Roupé KM, Valore EV, Sjöbring U, Roberts AA, Schmidtchen A, Ganz T. Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor. The Journal of Clinical Investigation. 116: 1878-85. PMID 16778986 DOI: 10.1172/Jci28422  0.378
2006 Nemeth E, Ganz T. Hepcidin and iron-loading anemias. Haematologica. 91: 727-32. PMID 16769573  0.629
2006 Linzmeier RM, Ganz T. Copy number polymorphisms are not a common feature of innate immune genes. Genomics. 88: 122-6. PMID 16617005 DOI: 10.1016/J.Ygeno.2006.03.005  0.345
2006 Ganz T, Nemeth E. Iron imports. IV. Hepcidin and regulation of body iron metabolism. American Journal of Physiology. Gastrointestinal and Liver Physiology. 290: G199-203. PMID 16407589 DOI: 10.1152/Ajpgi.00412.2005  0.719
2006 Ganz T. Molecular pathogenesis of anemia of chronic disease. Pediatric Blood & Cancer. 46: 554-7. PMID 16261603 DOI: 10.1002/Pbc.20656  0.578
2006 Nemeth E, Preza GC, Jung CL, Kaplan J, Waring AJ, Ganz T. The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. Blood. 107: 328-33. PMID 16141345 DOI: 10.1182/Blood-2005-05-2049  0.819
2006 Sharma S, Nemeth E, Chen Y, Huston A, Roodman G, Goodnough J, Ganz T, Lichtenstein A. Hepcidin Overproduction Mediates the Anemia of Multiple Myeloma. Blood. 108: 516-516. DOI: 10.1182/Blood.V108.11.516.516  0.803
2006 Winder A, Lefkowitz R, Ghoti H, Leiba M, Ganz T, Nemeth E, Rachmilewitz E. Urinary Hepcidin Excretion in Patients with Myelodysplastic Syndrome (MDS) and Myelofibrosis (MF). Blood. 108: 2620-2620. DOI: 10.1182/Blood.V108.11.2620.2620  0.654
2006 Rivera S, Pak M, Lopez MA, Gabayan V, Ganz T. Hepcidin Suppression Following Phlebotomy Is Regulated by an Erythropoietic Regulator Found in Serum. Blood. 108: 1554-1554. DOI: 10.1182/Blood.V108.11.1554.1554  0.744
2006 Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima H, Fellermann K, Ganz T, et al. Reduced Paneth Cell α-Defensins and Antimicrobial Activity in Ileal Crohn's Disease Inflammatory Bowel Diseases. 12: S20. DOI: 10.1097/00054725-200604002-00040  0.344
2006 Stenger S, Liu P, Meinken C, Ganz T, Bals R, Zügel U, Steinmeyer A, Ficker J, Modlin R, Röllinghoff M, Wagner M. Toll-like Rezeptoren induzieren einen Vitamin D abhängigen Abwehrmechanismus gegen Mycobacterium tuberculosis in Alveolarmakrophagen Pneumologie. 60. DOI: 10.1055/s-2006-933856  0.2
2006 Ropert M, Nemeth E, Mosser A, Dehais V, Troadec M, Le Lan C, Détivaud L, Loréal O, David V, Deugnier Y, Ganz T, Jouanolle A, Brissot P. CA 35-Expression de l’hepcidine au cours de la surcharge en fer par mutation du gène de la ferroportine (hémochromatose de type 4) : une étude de 16 cas GastroentéRologie Clinique Et Biologique. 30: 1066. DOI: 10.1016/S0399-8320(06)73445-5  0.191
2005 Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima H, Fellermann K, Ganz T, et al. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proceedings of the National Academy of Sciences of the United States of America. 102: 18129-34. PMID 16330776 DOI: 10.1073/Pnas.0505256102  0.377
2005 Roecker L, Meier-Buttermilch R, Brechtel L, Nemeth E, Ganz T. Iron-regulatory protein hepcidin is increased in female athletes after a marathon. European Journal of Applied Physiology. 95: 569-71. PMID 16249921 DOI: 10.1007/S00421-005-0055-Y  0.635
2005 Cole AM, Thapa DR, Gabayan V, Liao HI, Liu L, Ganz T. Decreased clearance of Pseudomonas aeruginosa from airways of mice deficient in lysozyme M. Journal of Leukocyte Biology. 78: 1081-5. PMID 16204648 DOI: 10.1189/Jlb.0205073  0.376
2005 Porto G, Roetto A, Daraio F, Pinto JP, Almeida S, Bacelar C, Nemeth E, Ganz T, Camaschella C. A Portuguese patient homozygous for the -25G>A mutation of the HAMP promoter shows evidence of steady-state transcription but fails to up-regulate hepcidin levels by iron. Blood. 106: 2922-3. PMID 16204153 DOI: 10.1182/Blood-2005-04-1630  0.573
2005 Ganz T. Cellular iron: ferroportin is the only way out. Cell Metabolism. 1: 155-7. PMID 16054057 DOI: 10.1016/J.Cmet.2005.02.005  0.602
2005 Porter E, Yang H, Yavagal S, Preza GC, Murillo O, Lima H, Greene S, Mahoozi L, Klein-Patel M, Diamond G, Gulati S, Ganz T, Rice PA, Quayle AJ. Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions. Infection and Immunity. 73: 4823-33. PMID 16040996 DOI: 10.1128/Iai.73.8.4823-4833.2005  0.787
2005 Linzmeier RM, Ganz T. Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23. Genomics. 86: 423-30. PMID 16039093 DOI: 10.1016/J.Ygeno.2005.06.003  0.335
2005 Lin L, Goldberg YP, Ganz T. Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood. 106: 2884-9. PMID 15998830 DOI: 10.1182/blood-2005-05-1845  0.489
2005 Zoller H, McFarlane I, Theurl I, Stadlmann S, Nemeth E, Oxley D, Ganz T, Halsall DJ, Cox TM, Vogel W. Primary iron overload with inappropriate hepcidin expression in V162del ferroportin disease. Hepatology (Baltimore, Md.). 42: 466-72. PMID 15986403 DOI: 10.1002/Hep.20775  0.696
2005 Shen B, Porter EM, Reynoso E, Shen C, Ghosh D, Connor JT, Drazba J, Rho HK, Gramlich TL, Li R, Ormsby AH, Sy MS, Ganz T, Bevins CL. Human defensin 5 expression in intestinal metaplasia of the upper gastrointestinal tract. Journal of Clinical Pathology. 58: 687-94. PMID 15976333 DOI: 10.1136/Jcp.2004.022426  0.355
2005 De Domenico I, Ward DM, Nemeth E, Vaughn MB, Musci G, Ganz T, Kaplan J. The molecular basis of ferroportin-linked hemochromatosis. Proceedings of the National Academy of Sciences of the United States of America. 102: 8955-60. PMID 15956209 DOI: 10.1073/Pnas.0503804102  0.643
2005 Rivera S, Nemeth E, Gabayan V, Lopez MA, Farshidi D, Ganz T. Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood. 106: 2196-9. PMID 15933050 DOI: 10.1182/Blood-2005-04-1766  0.797
2005 Ganz T. Defensins and other antimicrobial peptides: a historical perspective and an update. Combinatorial Chemistry & High Throughput Screening. 8: 209-17. PMID 15892623 DOI: 10.2174/1386207053764594  0.392
2005 Miller LS, Sørensen OE, Liu PT, Jalian HR, Eshtiaghpour D, Behmanesh BE, Chung W, Starner TD, Kim J, Sieling PA, Ganz T, Modlin RL. TGF-alpha regulates TLR expression and function on epidermal keratinocytes. Journal of Immunology (Baltimore, Md. : 1950). 174: 6137-43. PMID 15879109 DOI: 10.4049/Jimmunol.174.10.6137  0.361
2005 Liuzzi JP, Lichten LA, Rivera S, Blanchard RK, Aydemir TB, Knutson MD, Ganz T, Cousins RJ. Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proceedings of the National Academy of Sciences of the United States of America. 102: 6843-8. PMID 15863613 DOI: 10.1073/Pnas.0502257102  0.663
2005 Sørensen OE, Thapa DR, Rosenthal A, Liu L, Roberts AA, Ganz T. Differential regulation of beta-defensin expression in human skin by microbial stimuli. Journal of Immunology (Baltimore, Md. : 1950). 174: 4870-9. PMID 15814714 DOI: 10.4049/Jimmunol.174.8.4870  0.401
2005 Détivaud L, Nemeth E, Boudjema K, Turlin B, Troadec MB, Leroyer P, Ropert M, Jacquelinet S, Courselaud B, Ganz T, Brissot P, Loréal O. Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function. Blood. 106: 746-8. PMID 15797999 DOI: 10.1182/Blood-2004-12-4855  0.652
2005 Ganz T. Hepcidin - A regular of intestinal iron absorption and iron recycling by macrophages Best Practice and Research: Clinical Haematology. 18: 171-182. PMID 15737883 DOI: 10.1016/J.Beha.2004.08.020  0.627
2005 Papanikolaou G, Tzilianos M, Christakis JI, Bogdanos D, Tsimirika K, MacFarlane J, Goldberg YP, Sakellaropoulos N, Ganz T, Nemeth E. Hepcidin in iron overload disorders. Blood. 105: 4103-5. PMID 15671438 DOI: 10.1182/Blood-2004-12-4844  0.714
2005 Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C. Hepcidin is decreased in TFR2 hemochromatosis. Blood. 105: 1803-6. PMID 15486069 DOI: 10.1182/Blood-2004-08-3042  0.682
2005 Rivera S, Liu L, Nemeth E, Gabayan V, Sorensen OE, Ganz T. Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood. 105: 1797-802. PMID 15479721 DOI: 10.1182/Blood-2004-08-3375  0.782
2005 Rivera S, Ganz T. HEPCIDIN IS THE PRINCIPLE MEDIATOR OF ANEMIA OF INFLAMMATION Chest. 128: 149S. DOI: 10.1378/Chest.128.4_Meetingabstracts.149S-C  0.668
2005 Lin L, Goldberg YP, Ganz T. Sensing Iron: Reciprocal Regulation of Hepcidin mRNA by Soluble and Cell-Associated Hemojuvelin. Blood. 106: 512-512. DOI: 10.1182/Blood.V106.11.512.512  0.57
2005 Nemeth E, Loreal O, Le Lan C, Ropert M, Troadec M, Detivaud L, Jard C, Pouchard M, Le Treut A, Deugnier Y, Ganz T, Brissot P. Altered Hepcidin Regulation in Hereditary Hemochromatosis and Dysmetabolic Hyperferritinemia. Blood. 106: 3590-3590. DOI: 10.1182/Blood.V106.11.3590.3590  0.707
2005 Nemeth E, Origa R, Ganz T, Galanello R. Urinary Hepcidin in Thalassemic Syndromes. Blood. 106: 3589-3589. DOI: 10.1182/Blood.V106.11.3589.3589  0.715
2005 Rivera S, Lopez M, Farshidi D, Gabayan V, Ganz T. Ceruloplasmin Is Essential for the Mobilization of Tissue Iron Stores. Blood. 106: 3581-3581. DOI: 10.1182/Blood.V106.11.3581.3581  0.749
2005 Lehrer RI, Bevins CL, Ganz T. Defensins and other antimicrobial peptides and proteins Mucosal Immunology, Two-Volume Set. 95-110. DOI: 10.1016/B978-012491543-5/50010-3  0.306
2004 Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science (New York, N.Y.). 306: 2090-3. PMID 15514116 DOI: 10.1126/Science.1104742  0.713
2004 Ross DJ, Cole AM, Yoshioka D, Park AK, Belperio JA, Laks H, Strieter RM, Lynch JP, Kubak B, Ardehali A, Ganz T. Increased bronchoalveolar lavage human beta-defensin type 2 in bronchiolitis obliterans syndrome after lung transplantation. Transplantation. 78: 1222-4. PMID 15502724 DOI: 10.1097/01.Tp.0000137265.18491.75  0.389
2004 Kalfa VC, Spector SL, Ganz T, Cole AM. Lysozyme levels in the nasal secretions of patients with perennial allergic rhinitis and recurrent sinusitis Annals of Allergy, Asthma and Immunology. 93: 288-292. PMID 15478391 DOI: 10.1016/S1081-1206(10)61503-7  0.377
2004 Ganz T. Defensins: Antimicrobial peptides of vertebrates Comptes Rendus - Biologies. 327: 539-549. PMID 15330253 DOI: 10.1016/J.Crvi.2003.12.007  0.388
2004 Ganz T. Hepcidin in iron metabolism Current Opinion in Hematology. 11: 251-254. PMID 15314524 DOI: 10.1097/00062752-200407000-00004  0.616
2004 Matthes T, Aguilar-Martinez P, Pizzi-Bosman L, Darbellay R, Rubbia-Brandt L, Giostra E, Michel M, Ganz T, Beris P. Severe hemochromatosis in a Portuguese family associated with a new mutation in the 5'-UTR of the HAMP gene. Blood. 104: 2181-3. PMID 15198949 DOI: 10.1182/Blood-2004-01-0332  0.505
2004 Lee HY, Andalibi A, Webster P, Moon SK, Teufert K, Kang SH, Li JD, Nagura M, Ganz T, Lim DJ. Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae. Bmc Infectious Diseases. 4: 12. PMID 15125783 DOI: 10.1186/1471-2334-4-12  0.359
2004 Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. The Journal of Clinical Investigation. 113: 1271-6. PMID 15124018 DOI: 10.1172/Jci20945  0.754
2004 Papanikolaou G, Samuels ME, Ludwig EH, MacDonald ML, Franchini PL, Dubé MP, Andres L, MacFarlane J, Sakellaropoulos N, Politou M, Nemeth E, Thompson J, Risler JK, Zaborowska C, Babakaiff R, ... ... Ganz T, et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nature Genetics. 36: 77-82. PMID 14647275 DOI: 10.1038/Ng1274  0.633
2004 Rivera S, Gabayan V, Ganz T. In Chronic Inflammation, There Exists an IL-6 Independent Pathway for the Induction of Hepcidin. Blood. 104: 3205-3205. DOI: 10.1182/Blood.V104.11.3205.3205  0.663
2004 Rivera S, Liu L, Nemeth E, Gabayan V, Ganz T. Hepcidin Contributes to Anemia of Malignancy by Causing Sequestration of Iron in Hepatic Stores. Blood. 104: 3197-3197. DOI: 10.1182/Blood.V104.11.3197.3197  0.788
2004 Ganz T. Is TfR2 the iron sensor? Blood. 104: 3839-3840. DOI: 10.1182/Blood-2004-09-3664  0.567
2004 Valore EV, Ganz T. 12 BACTERIAL VAGINOSIS IS ASSOCIATED WITH DEFICIENCY OF ANTIMICROBIAL SUBSTANCES IN VAGINAL FLUID. Journal of Investigative Medicine. 52: S402.5-S402. DOI: 10.1136/Jim-52-Suppl2-178  0.394
2004 Sorensen OE, Thapa DR, Roberts AA, Ganz T. 11 DIFFERENTIAL REGULATION OF HUMAN β-DEFENSINS IN SQUAMOUS EPITHELIA. Journal of Investigative Medicine. 52: S402.4-S402. DOI: 10.1136/Jim-52-Suppl2-177  0.34
2004 Rivera S, Gabayan V, Ganz T. 10 INTERLEUKIN-6 IS NECESSARY FOR THE INDUCTION OF HEPCIDIN BY INFLAMMATION. Journal of Investigative Medicine. 52: S402.3-S402. DOI: 10.1136/Jim-52-Suppl2-176  0.644
2004 Nemeth E, Keller C, Taudorf S, Pedersen BK, Ganz T. 5 REGULATION OF HEPCIDIN RELEASE BY IL-6 AND DIETARY IRON IN HUMAN VOLUNTEERS. Journal of Investigative Medicine. 52: S401.5-S401. DOI: 10.1136/Jim-52-Suppl2-171  0.638
2004 Lin L, Nemeth E, Rivera S, Gabayan V, Ganz T. 4 IN VITRO ANALYSIS OF IRON-REGULATED HEPCIDIN EXPRESSION. Journal of Investigative Medicine. 52: S401.4-S401. DOI: 10.1136/Jim-52-Suppl2-170  0.785
2003 Hertz CJ, Wu Q, Porter EM, Zhang YJ, Weismüller KH, Godowski PJ, Ganz T, Randell SH, Modlin RL. Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2. Journal of Immunology (Baltimore, Md. : 1950). 171: 6820-6. PMID 14662888 DOI: 10.4049/Jimmunol.171.12.6820  0.397
2003 Ganz T. Antimicrobial polypeptides. Journal of Leukocyte Biology. 75: 34-8. PMID 12960278 DOI: 10.1189/jlb.0403150  0.276
2003 Ganz T. Defensins: Antimicrobial peptides of innate immunity Nature Reviews Immunology. 3: 710-720. PMID 12949495 DOI: 10.1038/Nri1180  0.396
2003 Milner SM, Cole A, Ortega MR, Bakir MH, Gulati S, Bhat S, Ganz T. Inducibility of HBD-2 in acute burns and chronic conditions of the lung. Burns : Journal of the International Society For Burn Injuries. 29: 553-5. PMID 12927979 DOI: 10.1016/S0305-4179(03)00145-1  0.379
2003 Sørensen OE, Cowland JB, Theilgaard-Mönch K, Liu L, Ganz T, Borregaard N. Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors. Journal of Immunology (Baltimore, Md. : 1950). 170: 5583-9. PMID 12759437 DOI: 10.4049/Jimmunol.170.11.5583  0.379
2003 Oren A, Ganz T, Liu L, Meerloo T. In human epidermis, β-defensin 2 is packaged in lamellar bodies Experimental and Molecular Pathology. 74: 180-182. PMID 12710950 DOI: 10.1016/S0014-4800(02)00023-0  0.265
2003 Donald CD, Sun CQ, Lim SD, Macoska J, Cohen C, Amin MB, Young AN, Ganz TA, Marshall FF, Petros JA. Cancer-specific loss of beta-defensin 1 in renal and prostatic carcinomas. Laboratory Investigation; a Journal of Technical Methods and Pathology. 83: 501-5. PMID 12695553  0.2
2003 Ganz T. Gut defence Nature. 422: 478-479. PMID 12673233 DOI: 10.1038/422478A  0.342
2003 Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation Blood. 102: 783-788. PMID 12663437 DOI: 10.1182/Blood-2003-03-0672  0.623
2003 Ganz T. Angiogenin: An antimicrobial ribonuclease Nature Immunology. 4: 213-214. PMID 12605229 DOI: 10.1038/Ni0303-213  0.352
2003 Cole AM, Liao HI, Ganz T, Yang OO, Klenk HD. Antibacterial activity of peptides derived from envelope glycoproteins of HIV-1 Febs Letters. 535: 195-199. PMID 12560103 DOI: 10.1016/S0014-5793(02)03860-7  0.369
2003 Liu L, Roberts AA, Ganz T. By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide. Journal of Immunology (Baltimore, Md. : 1950). 170: 575-80. PMID 12496445 DOI: 10.4049/Jimmunol.170.1.575  0.401
2003 Com E, Bourgeon F, Evrard B, Ganz T, Colleu D, Jégou B, Pineau C. Expression of antimicrobial defensins in the male reproductive tract of rats, mice, and humans. Biology of Reproduction. 68: 95-104. PMID 12493700 DOI: 10.1095/Biolreprod.102.005389  0.396
2003 Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood. 101: 2461-3. PMID 12433676 DOI: 10.1182/Blood-2002-10-3235  0.702
2003 Ganz T, Gabayan V, Liao HI, Liu L, Oren A, Graf T, Cole AM. Increased inflammation in lysozyme M-deficient mice in response to Micrococcus luteus and its peptidoglycan Blood. 101: 2388-2392. PMID 12411294 DOI: 10.1182/Blood-2002-07-2319  0.418
2003 Ganz T. The role of antimicrobial peptides in innate immunity Integrative and Comparative Biology. 43: 300-304. DOI: 10.1093/Icb/43.2.300  0.416
2003 Ganz T. Erratum: Angiogenin: an antimicrobial ribonuclease Nature Immunology. 4: 394-394. DOI: 10.1038/Ni0403-394B  0.325
2002 Huang GT, Zhang HB, Kim D, Liu L, Ganz T. A model for antimicrobial gene therapy: demonstration of human beta-defensin 2 antimicrobial activities in vivo. Human Gene Therapy. 13: 2017-25. PMID 12489997 DOI: 10.1089/10430340260395875  0.284
2002 Ganz T. The role of hepcidin in iron sequestration during infections and in the pathogenesis of anemia of chronic disease The Israel Medical Association Journal : Imaj. 4: 1043-1045. PMID 12489503  0.559
2002 Cole AM, Liao HI, Stuchlik O, Tilan J, Pohl J, Ganz T. Cationic polypeptides are required for antibacterial activity of human airway fluid Journal of Immunology. 169: 6985-6991. PMID 12471133 DOI: 10.4049/Jimmunol.169.12.6985  0.366
2002 Ganz T. Immunology: Versatile defensins Science. 298: 977-979. PMID 12411693 DOI: 10.1126/Science.1078708  0.336
2002 Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T, Gallo RL, Leung DY. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. The New England Journal of Medicine. 347: 1151-60. PMID 12374875 DOI: 10.1056/Nejmoa021481  0.378
2002 Valore EV, Park CH, Igreti SL, Ganz T. Antimicrobial components of vaginal fluid American Journal of Obstetrics and Gynecology. 187: 561-568. PMID 12237628 DOI: 10.1067/Mob.2002.125280  0.336
2002 Hunter HN, Fulton DB, Ganz T, Vogel HJ. The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. The Journal of Biological Chemistry. 277: 37597-603. PMID 12138110 DOI: 10.1074/Jbc.M205305200  0.492
2002 Hein M, Valore EV, Helmig RB, Uldbjerg N, Ganz T. Antimicrobial factors in the cervical mucus plug American Journal of Obstetrics and Gynecology. 187: 137-144. PMID 12114901 DOI: 10.1067/Mob.2002.123034  0.35
2002 Moon SK, Lee HY, Li JD, Nagura M, Kang SH, Chun YM, Linthicum FH, Ganz T, Andalibi A, Lim DJ. Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells. Biochimica Et Biophysica Acta. 1590: 41-51. PMID 12063167 DOI: 10.1016/S0167-4889(02)00196-9  0.372
2002 Levy O, Sisson RB, Fryer HE, Goldmann D, Valore E, Ganz T, White ML, Carroll SF, Lehmann L, Guinan EC. Neutrophil defense in patients undergoing bone marrow transplantation: bactericidal/permeability-increasing protein (BPI) and defensins in graft-derived neutrophils. Transplantation. 73: 1522-6. PMID 12023636 DOI: 10.1097/00007890-200205150-00027  0.38
2002 Ghosh D, Porter E, Shen B, Lee SK, Wilk D, Drazba J, Yadav SP, Crabb JW, Ganz T, Bevins CL. Paneth cell trypsin is the processing enzyme for human defensin-5. Nature Immunology. 3: 583-90. PMID 12021776 DOI: 10.1038/Ni797  0.396
2002 Cole AM, Ganz T. Antimicrobial peptides and proteins in the CF airway Methods in Molecular Medicine. 70: 447-464. PMID 11917542 DOI: 10.1385/1-59259-187-6:447  0.37
2002 Ganz T. Epithelia: Not just physical barriers Proceedings of the National Academy of Sciences of the United States of America. 99: 3357-3358. PMID 11904396 DOI: 10.1073/Pnas.072073199  0.387
2002 Ganz T. Antimicrobial polypeptides in host defense of the respiratory tract Journal of Clinical Investigation. 109: 693-697. PMID 11901174 DOI: 10.1172/Jci15218  0.371
2002 Henneman E, Dracup K, Ganz T, Molayeme O, Cooper CB. Using a collaborative weaning plan to decrease duration of mechanical ventilation and length of stay in the intensive care unit for patients receiving long-term ventilation. American Journal of Critical Care : An Official Publication, American Association of Critical-Care Nurses. 11: 132-40. PMID 11888125  0.209
2002 Porter EM, Bevins CL, Ghosh D, Ganz T. The multifaceted Paneth cell Cellular and Molecular Life Sciences. 59: 156-170. PMID 11846026 DOI: 10.1007/S00018-002-8412-Z  0.373
2002 Liu AY, Destoumieux D, Wong AV, Park CH, Valore EV, Liu L, Ganz T. Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. The Journal of Investigative Dermatology. 118: 275-81. PMID 11841544 DOI: 10.1046/J.0022-202X.2001.01651.X  0.385
2002 Lehrer RI, Ganz T. Defensins of vertebrate animals Current Opinion in Immunology. 14: 96-102. PMID 11790538 DOI: 10.1016/S0952-7915(01)00303-X  0.636
2002 Sanchez JF, Wojcik F, Yang YS, Strub MP, Strub JM, Van Dorsselaer A, Martin M, Lehrer R, Ganz T, Chavanieu A, Calas B, Aumelas A. Overexpression and structural study of the cathelicidin motif of the protegrin-3 precursor. Biochemistry. 41: 21-30. PMID 11771999 DOI: 10.1021/Bi010930A  0.643
2002 Lehrer RI, Ganz T. Cathelicidins: A family of endogenous antimicrobial peptides Current Opinion in Hematology. 9: 18-22. PMID 11753073 DOI: 10.1097/00062752-200201000-00004  0.662
2002 Henneman E, Dracup K, Ganz T, Molayeme O, Cooper CB. Using a Collaborative Weaning Plan to Decrease Duration of Mechanical Ventilation and Length of Stay in the Intensive Care Unit for Patients Receiving Long-Term Ventilation American Journal of Critical Care. 11: 132-140. DOI: 10.4037/Ajcc2002.11.2.132  0.332
2002 Hunter HN, Fulton DB, Ganz T, Vogel HJ. Solution Structure of Hepcidin-20 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb1M4E/Pdb  0.307
2002 Ganz T. Reconstitution of active NADPH oxidase in nonhematopoietic cells: a milestone in the study of a complex system Blood. 99: 2635-2635. DOI: 10.1182/Blood.V99.8.2635A  0.332
2002 Ross D, Cole A, Park A, Yoshioka D, Strieter R, Belperio J, Kubak B, Laks H, Ardehali A, Ganz T. Increased BAL human β-defensin-2 bronchiolitis obliterans syndrome after lung transplantation The Journal of Heart and Lung Transplantation. 21: 75-76. DOI: 10.1016/S1053-2498(01)00492-2  0.326
2001 Cole AM, Tahk S, Oren A, Yoshioka D, Kim YH, Park A, Ganz T. Determinants of Staphylococcus aureus nasal carriage Clinical and Diagnostic Laboratory Immunology. 8: 1064-1069. PMID 11687441 DOI: 10.1128/Cdli.8.6.1064-1069.2001  0.384
2001 Sanchez JF, Hoh F, Strub MP, Strub JM, Van Dorsselaer A, Lehrer R, Ganz T, Chavanieu A, Calas B, Dumas C, Aumelas A. Expression, purification, crystallization and preliminary X-ray analysis of the cathelicidin motif of the protegrin-3 precursor. Acta Crystallographica. Section D, Biological Crystallography. 57: 1677-9. PMID 11679742 DOI: 10.1107/S0907444901012598  0.338
2001 Porro GA, Lee JH, de Azavedo J, Crandall I, Whitehead T, Tullis E, Ganz T, Liu M, Slutsky AS, Zhang H. Direct and indirect bacterial killing functions of neutrophil defensins in lung explants. American Journal of Physiology. Lung Cellular and Molecular Physiology. 281: L1240-7. PMID 11597916 DOI: 10.1152/Ajplung.2001.281.5.L1240  0.351
2001 Dale BA, Kimball JR, Krisanaprakornkit S, Roberts F, Robinovitch M, O'Neal R, Valore EV, Ganz T, Anderson GM, Weinberg A. Localized antimicrobial peptide expression in human gingiva. Journal of Periodontal Research. 36: 285-94. PMID 11585115 DOI: 10.1034/J.1600-0765.2001.360503.X  0.408
2001 Hein M, Helmig RB, Schønheyder HC, Ganz T, Uldbjerg N. An in vitro study of antibacterial properties of the cervical mucus plug in pregnancy American Journal of Obstetrics and Gynecology. 185: 586-592. PMID 11568782 DOI: 10.1067/Mob.2001.116685  0.34
2001 Cole AM, Kim YH, Tahk S, Hong T, Weis P, Waring AJ, Ganz T. Calcitermin, a novel antimicrobial peptide isolated from human airway secretions Febs Letters. 504: 5-10. PMID 11522286 DOI: 10.1016/S0014-5793(01)02731-4  0.405
2001 Diamond DL, Kimball JR, Krisanaprakornkit S, Ganz T, Dale BA. Detection of β-defensins secreted by human oral epithelial cells Journal of Immunological Methods. 256: 65-76. PMID 11516756 DOI: 10.1016/S0022-1759(01)00442-2  0.383
2001 Ganz T. Chemistry: Rings of destruction Nature. 412: 392-393. PMID 11473296 DOI: 10.1038/35086680  0.357
2001 Cole AM, Ganz T, Liese AM, Burdick MD, Liu L, Strieter RM. Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity Journal of Immunology. 167: 623-627. PMID 11441062 DOI: 10.4049/Jimmunol.167.2.623  0.382
2001 Ganz T. Fatal attraction evaded: How pathogenic bacteria resist cationic polypeptides Journal of Experimental Medicine. 193. PMID 11342596 DOI: 10.1084/Jem.193.9.F31  0.42
2001 Ganz T. Antimicrobial proteins and peptides in host defense Seminars in Respiratory Infections. 16: 4-10. PMID 11309707 DOI: 10.1053/Srin.2001.22723  0.396
2001 Sawai MV, Jia HP, Liu L, Aseyev V, Wiencek JM, McCray PB, Ganz T, Kearney WR, Tack BF. The NMR structure of human β-defensin-2 reveals a novel α-helical segment Biochemistry. 40: 3810-3816. PMID 11300761 DOI: 10.1021/Bi002519D  0.345
2001 Henneman E, Dracup K, Ganz T, Molayeme O, Cooper C. Effect of a collaborative weaning plan on patient outcome in the critical care setting. Critical Care Medicine. 29: 297-303. PMID 11246309 DOI: 10.1097/00003246-200102000-00013  0.308
2001 Peng Jia H, Schutte BC, Schudy A, Linzmeier R, Guthmiller JM, Johnson GK, Tack BF, Mitros JP, Rosenthal A, Ganz T, McCray PB. Discovery of new human β-defensins using a genomics-based approach Gene. 263: 211-218. PMID 11223260 DOI: 10.1016/S0378-1119(00)00569-2  0.37
2001 Ganz T. Defensins in the urinary tract and other tissues Journal of Infectious Diseases. 183. PMID 11171012 DOI: 10.1086/318838  0.428
2001 Cole AM, Shi J, Ceccarelli A, Kim YH, Park A, Ganz T. Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds Blood. 97: 297-304. PMID 11133774 DOI: 10.1182/Blood.V97.1.297  0.388
2001 Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver Journal of Biological Chemistry. 276: 7806-7810. PMID 11113131 DOI: 10.1074/Jbc.M008922200  0.41
2001 Sawai MV, Jia HP, Liu L, Aseyev V, Wiencek JM, PBMJ, Ganz T, Kearney WR, Tack BF. The NMR structure of human beta-defensin-2 reveals a novel alpha-helical segment. Biochemistry. 40: 3810-3816. DOI: 10.2210/Pdb1Fqq/Pdb  0.34
2001 Ganz T. Antimicrobial peptides: from host defense to therapeutics Aids. 15: S57. DOI: 10.1097/00002030-200102001-00080  0.376
2000 Ganz T. Paneth cells - Guardians of the gut cell hatchery Nature Immunology. 1: 99-100. PMID 11248797 DOI: 10.1038/77884  0.356
2000 Ernst WA, Thoma-Uszynski S, Teitelbaum R, Ko C, Hanson DA, Clayberger C, Krensky AM, Leippe M, Bloom BR, Ganz T, Modlin RL. Granulysin, a T cell product, kills bacteria by altering membrane permeability. Journal of Immunology (Baltimore, Md. : 1950). 165: 7102-8. PMID 11120840 DOI: 10.4049/Jimmunol.165.12.7102  0.369
2000 Bellm L, Lehrer RI, Ganz T. Protegrins: New antibiotics of mammalian origin Expert Opinion On Investigational Drugs. 9: 1731-1742. PMID 11060772 DOI: 10.1517/13543784.9.8.1731  0.384
2000 Cole AM, Ganz T. Human antimicrobial peptides: Analysis and application Biotechniques. 29: 822-831. PMID 11056814 DOI: 10.2144/00294Rv01  0.398
2000 Ortega MR, Ganz T, Milner SM. Human beta defensin is absent in burn blister fluid. Burns : Journal of the International Society For Burn Injuries. 26: 724-6. PMID 11024605 DOI: 10.1016/S0305-4179(00)00052-8  0.37
2000 O'Neil DA, Cole SP, Martin-Porter E, Housley MP, Liu L, Ganz T, Kagnoff MF. Regulation of human beta-defensins by gastric epithelial cells in response to infection with Helicobacter pylori or stimulation with interleukin-1. Infection and Immunity. 68: 5412-5. PMID 10948173 DOI: 10.1128/Iai.68.9.5412-5415.2000  0.369
2000 Cole AM, Wu M, Kim YH, Ganz T. Microanalysis of antimicrobial properties of human fluids Journal of Microbiological Methods. 41: 135-143. PMID 10889310 DOI: 10.1016/S0167-7012(00)00140-8  0.347
2000 Tunzi CR, Harper PA, Bar-Oz B, Valore EV, Semple JL, Watson-MacDonell J, Ganz T, Ito S. Beta-defensin expression in human mammary gland epithelia. Pediatric Research. 48: 30-5. PMID 10879797 DOI: 10.1203/00006450-200007000-00008  0.394
2000 Borregaard N, Garred P, Svejgaard A, Elsbach P, Ganz T. Innate immunity: From plants to humans Immunology Today. 21: 68-70. PMID 10652463 DOI: 10.1016/S0167-5699(99)01570-4  0.326
2000 Higazi AA, Nassar T, Ganz T, Rader DJ, Udassin R, Bdeir K, Hiss E, Sachais BS, Williams KJ, Leitersdorf E, Cines DB. The α-defensins stimulate proteoglycan-dependent catabolism of low-density lipoprotein by vascular cells : a new class of inflammatory apolipoprotein and a possible contributor to atherogenesis Blood. 96: 1393-1398. DOI: 10.1182/Blood.V96.4.1393.H8001393_1393_1398  0.365
2000 Shen B, Lashner B, Achkar J, Brzezinski A, Ghosh D, Seidner D, Porter E, Ganz T, Fazio V, Bevins C. Human defensin-5 immunohistochemistry and Paneth cell morphology helps to differentiate Crohn's colitis from active ulcerative colitis The American Journal of Gastroenterology. 95: 2501-2501. DOI: 10.1111/j.1572-0241.2000.02668.x  0.244
2000 Ortega MR, Ganz T, Milner SM. Human Beta Defensin 2 Is Absent in Burn Blister Fluid: 182. Journal of Burn Care & Rehabilitation. 21. DOI: 10.1097/00004630-200001001-00182  0.319
2000 Ghosh D, Porter EM, Wilk DJ, Poles MA, Ganz T, Bevins CL. Proteolytic cleavage of human enteric defensin 5 (HD5) precursor by intestinal proteases Gastroenterology. 118: A815. DOI: 10.1016/S0016-5085(00)85404-9  0.356
2000 O'Neil DA, Cole SP, Martin-Porter E, Liu L, Ganz T, Kagnoff MF. Helicobacter pylori and IL-1 upregulate the expression of human b-defensin (HBD)-2 but not HBD-1 in gastric epithelium Gastroenterology. 118: A695. DOI: 10.1016/S0016-5085(00)84913-6  0.336
2000 Shen B, Lashner BA, Ghosh D, Porter EM, Achkar J, Goldblum JR, Brzezinski A, Strong SA, Seidner DL, Ganz T, Fazio VW, Bevins CL. Human enteric defensin-5 (HD5) expression in acute pouchitis Gastroenterology. 118: A1136. DOI: 10.1016/S0016-5085(00)80354-6  0.346
2000 Shen B, Lashner BA, Ghosh D, Porter EM, Achkar J, Goldblum JR, Brzezinski A, Strong SA, Seidner DL, Ganz T, Fazio VW, Bevins CL. Enteric defensin in Crohn's disease and ulcerative colitis Gastroenterology. 118: A1136. DOI: 10.1016/S0016-5085(00)80353-4  0.353
2000 Shen B, Achkar J, Lashner B, Brzezinski A, Ghosh D, Remzi F, Goldblum J, Fazio V, Seidner D, Ganz T, Bevins C. Upregulation of human defensin-5 in acute pouchitis suggests an infectious etiology The American Journal of Gastroenterology. 95: 2501-2502. DOI: 10.1016/S0002-9270(00)01461-1  0.352
1999 Levy O, Martin S, Eichenwald E, Ganz T, Valore E, Carroll SF, Lee K, Goldmann D, Thorne GM. Impaired innate immunity in the newborn: newborn neutrophils are deficient in bactericidal/permeability-increasing protein. Pediatrics. 104: 1327-33. PMID 10585984 DOI: 10.1542/Peds.104.6.1327  0.425
1999 Ganz T. Defensins and host defense Science. 286: 420-421. PMID 10577203 DOI: 10.1126/Science.286.5439.420  0.371
1999 Bevins CI, Martin-Porter E, Ganz T. Defensins and innate host defence of the gastrointestinal tract Gut. 45: 911-915. PMID 10562592 DOI: 10.1136/Gut.45.6.911  0.37
1999 Ganz T. Oxygen-independent microbicidal mechanisms of phagocytes Proceedings of the Association of American Physicians. 111: 390-395. PMID 10519158  0.236
1999 McKay MS, Olson E, Hesla MA, Panyutich A, Ganz T, Perkins S, Rossomando EF. Immunomagnetic recovery of human neutrophil defensins from the human gingival crevice. Oral Microbiology and Immunology. 14: 190-3. PMID 10495714 DOI: 10.1034/J.1399-302X.1999.140308.X  0.384
1999 Bdeir K, Cane W, Canziani G, Chaiken I, Weisel J, Koschinsky ML, Lawn RM, Bannerman PG, Sachais BS, Kuo A, Hancock MA, Tomaszewski J, Raghunath PN, Ganz T, Higazi AAR, et al. Defensin promotes the binding of lipoprotein(a) to vascular matrix Blood. 94: 2007-2019. PMID 10477730  0.25
1999 Ganz T, Lehrer RI. Antibiotic peptides from higher eukaryotes: Biology and applications Molecular Medicine Today. 5: 292-297. PMID 10377520 DOI: 10.1016/S1357-4310(99)01490-2  0.393
1999 Cole AM, Dewan P, Ganz T. Innate antimicrobial activity of nasal secretions Infection and Immunity. 67: 3267-3275. PMID 10377100 DOI: 10.1128/Iai.67.7.3267-3275.1999  0.387
1999 Linzmeier R, Ho CH, Hoang BV, Ganz T. A 450-kb contig of defensin genes on human chromosome 8p23 Gene. 233: 205-211. PMID 10375637 DOI: 10.1016/S0378-1119(99)00136-5  0.352
1999 Shi J, Zhang G, Wu H, Ross C, Blecha F, Ganz T. Porcine epithelial β-defensin 1 is expressed in the dorsal tongue at antimicrobial concentrations Infection and Immunity. 67: 3121-3127. PMID 10338529 DOI: 10.1128/Iai.67.6.3121-3127.1999  0.391
1999 Lehrer RI, Ganz T. Antimicrobial peptides in mammalian and insect host defence Current Opinion in Immunology. 11: 23-27. PMID 10047545 DOI: 10.1016/S0952-7915(99)80005-3  0.402
1999 Bdeir K, Cane W, Canziani G, Chaiken I, Weisel J, Koschinsky ML, Lawn RM, Bannerman PG, Sachais BS, Kuo A, Hancock MA, Tomaszewski J, Raghunath PN, Ganz T, Higazi AA, et al. Defensin Promotes the Binding of Lipoprotein(a) to Vascular Matrix Blood. 94: 2007-2019. DOI: 10.1182/Blood.V94.6.2007.418K12_2007_2019  0.356
1999 Henneman E, Dracup K, Ganz T, Cooper C, Molayeme O. EFFECT OF A COLLABORATIVE WEANING PLAN ON LONG TERM VENTILATOR PATIENTS IN THE CRITICAL CARE SETTING Critical Care Medicine. 27: 95A. DOI: 10.1097/00003246-199901001-00235  0.305
1999 Rivas L, Ganz T. Eukaryotic antibiotic peptides: Not only a membrane business Drug Discovery Today. 4: 254-256. DOI: 10.1016/S1359-6446(99)01358-6  0.36
1999 Henneman E, Dracup K, Ganz T, Cooper C, Molayeme O. Effect of a collaborative weaning plan on long term ventilator patients in the critical care setting Critical Care Medicine. 27: A95.  0.19
1998 Singh PK, Jia HP, Wiles K, Hesselberth J, Liu L, Conway BA, Greenberg EP, Valore EV, Welsh MJ, Ganz T, Tack BF, McCray PB. Production of beta-defensins by human airway epithelia. Proceedings of the National Academy of Sciences of the United States of America. 95: 14961-6. PMID 9843998 DOI: 10.1073/Pnas.95.25.14961  0.404
1998 Liu L, Wang L, Jia HP, Zhao C, Heng HHQ, Schutte BC, McCray PB, Ganz T. Structure and mapping of the human β-defensin HBD-2 gene and its expression at sites of inflammation Gene. 222: 237-244. PMID 9831658 DOI: 10.1016/S0378-1119(98)00480-6  0.363
1998 Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazi KR, Froelich CJ, Ganz T, Thoma-Uszynski S, Melián A, Bogdan C, Porcelli SA, Bloom BR, Krensky AM, Modlin RL. An antimicrobial activity of cytolytic T cells mediated by granulysin. Science (New York, N.Y.). 282: 121-5. PMID 9756476 DOI: 10.1126/Science.282.5386.121  0.362
1998 Porter EM, Poles MA, Lee JS, Naitoh J, Bevins CL, Ganz T. Isolation of human intestinal defensins from ileal neobladder urine Febs Letters. 434: 272-276. PMID 9742937 DOI: 10.1016/S0014-5793(98)00994-6  0.369
1998 Shi J, Ganz T. The role of protegrins and other elastase-activated polypeptides in the bactericidal properties of porcine inflammatory fluids Infection and Immunity. 66: 3611-3617. PMID 9673240 DOI: 10.1128/Iai.66.8.3611-3617.1998  0.414
1998 Valore EV, Park CH, Quayle AJ, Wiles KR, McCray PB, Ganz T. Human β-defensin-1: An antimicrobial peptide of urogenital tissues Journal of Clinical Investigation. 101: 1633-1642. PMID 9541493 DOI: 10.1172/Jci1861  0.417
1998 Zhang G, Wu H, Shi J, Ganz T, Ross CR, Blecha F. Molecular cloning and tissue expression of porcine β-defensin-1 Febs Letters. 424: 37-40. PMID 9537511 DOI: 10.1016/S0014-5793(98)00134-3  0.402
1998 Ganz T, Lehrer RI. Antimicrobial peptides of vertebrates Current Opinion in Immunology. 10: 41-44. PMID 9523109 DOI: 10.1016/S0952-7915(98)80029-0  0.388
1998 Poles M, Martin-Porter E, Lee J, Naitoh J, Anton P, Ganz T. What can urine teach us about intestinal defense? Gastroenterology. 114: A1062. DOI: 10.1016/S0016-5085(98)84322-9  0.335
1998 Ganz T. Defensins are not the principal antimicrobial substances in ASL Pediatric Pulmonology. 26: 130-131.  0.223
1997 Ganz T, Weiss J. Antimicrobial peptides of phagocytes and epithelia Seminars in Hematology. 34: 343-354. PMID 9347585  0.298
1997 Valore EV, Ganz T. Laboratory production of antimicrobial peptides in native conformation Methods in Molecular Biology (Clifton, N.J.). 78: 115-131. PMID 9276301 DOI: 10.1385/0-89603-408-9:115  0.367
1997 Liu L, Zhao C, Heng HHQ, Ganz T. The human β-defensin-1 and α-defensins are encoded by adjacent genes: Two peptide families with differing disulfide topology share a common ancestry Genomics. 43: 316-320. PMID 9268634 DOI: 10.1006/Geno.1997.4801  0.359
1997 Higazi AA, Lavi E, Bdeir K, Ulrich AM, Jamieson DG, Rader DJ, Usher DC, Kane W, Ganz T, Cines DB. Defensin stimulates the binding of lipoprotein (a) to human vascular endothelial and smooth muscle cells. Blood. 89: 4290-8. PMID 9192751 DOI: 10.1182/Blood.V89.12.4290  0.372
1997 Porter EM, Van Dam E, Valore EV, Ganz T. Broad-spectrum antimicrobial activity of human intestinal defensin 5 Infection and Immunity. 65: 2396-2401. PMID 9169780 DOI: 10.1128/Iai.65.6.2396-2401.1997  0.396
1997 Porter EM, Liu L, Oren A, Anton PA, Ganz T. Localization of human intestinal defensin 5 in paneth cell granules Infection and Immunity. 65: 2389-2395. PMID 9169779 DOI: 10.1128/Iai.65.6.2389-2395.1997  0.376
1997 Soong LB, Ganz T, Ellison A, Caughey GH. Purification and characterization of defensins from cystic fibrosis sputum Inflammation Research. 46: 98-102. PMID 9098722 DOI: 10.1007/S000110050114  0.368
1997 Lohner K, Latal A, Lehrer RI, Ganz T. Differential scanning microcalorimetry indicates that human defensin, HNP-2, interacts specifically with biomembrane mimetic systems Biochemistry. 36: 1525-1531. PMID 9063901 DOI: 10.1021/Bi961300P  0.377
1997 Ganz T, Lehrer RI. Antimicrobial peptides of leukocytes Current Opinion in Hematology. 4: 53-58. PMID 9050380 DOI: 10.1097/00062752-199704010-00009  0.402
1997 Panyutich A, Shi J, Boutz PL, Zhao C, Ganz T. Porcine polymorphonuclear leukocytes generate extracellular microbicidal activity by elastase-mediated activation of secreted proprotegrins Infection and Immunity. 65: 978-985. PMID 9038306 DOI: 10.1128/Iai.65.3.978-985.1997  0.409
1997 Gamper J, Flad T, Klatt T, Widmann S, Markovic-Lipkovski J, Halder T, Ganz T, Kalbacher H, Müller C. Expression of defensins in human renal cell carcinomas Immunology Letters. 56: 434. DOI: 10.1016/S0165-2478(97)86763-6  0.336
1996 Lehrer RI, Ganz T. Endogenous vertebrate antibiotics. Defensins, protegrins, and other cysteine-rich antimicrobial peptides Annals of the New York Academy of Sciences. 797: 228-239. PMID 8993365 DOI: 10.1111/J.1749-6632.1996.Tb52963.X  0.399
1996 Higazi AAR, Ganz T, Kariko K, Cines DB. Defensin modulates tissue-type plasminogen activator and plasminogen binding to fibrin and endothelial cells Journal of Biological Chemistry. 271: 17650-17655. PMID 8663495 DOI: 10.1074/Jbc.271.30.17650  0.376
1996 Valore EV, Martin E, Harwig SSL, Ganz T. Intramolecular inhibition of human defensin HNP-1 by its propiece Journal of Clinical Investigation. 97: 1624-1629. PMID 8601627 DOI: 10.1172/Jci118588  0.396
1996 Heng LH, Zhao C, Ganz T. Human alpha- and beta-defensins evolved from a common premammalian ancestor peptide Journal of Investigative Medicine. 44.  0.273
1996 Valoce E, Quayie A, Robbins C, Ganz T. A human beta-defensin is produced by urogenital epithelia Journal of Investigative Medicine. 44.  0.272
1996 Higazi AAIR, Ganz T, Kariko K, Cines D. Defensin modulates IPA and plasminogen binding to fibrin and endothelial cells Fibrinolysis. 10: 33.  0.293
1995 Panyutich AV, Hiemstra PS, van Wetering S, Ganz T. Human neutrophil defensin and serpins form complexes and inactivate each other American Journal of Respiratory Cell and Molecular Biology. 12: 351-357. PMID 7873202 DOI: 10.1165/Ajrcmb.12.3.7873202  0.34
1995 Liu L, Ganz T. The pro region of human neutrophil defensin contains a motif that is essential for normal subcellular sorting Blood. 85: 1095-1103. PMID 7849297 DOI: 10.1182/Blood.V85.4.1095.Bloodjournal8541095  0.405
1995 Liu L, Oren A, Ganz T. Murine 32D cl3 cells - A transfectable model of phagocyte granule formation Journal of Immunological Methods. 181: 253-258. PMID 7745254 DOI: 10.1016/0022-1759(95)00009-Y  0.342
1995 Martin E, Ganz T, Lehrer RI. Defensins and other endogenous peptide antibiotics of vertebrates Journal of Leukocyte Biology. 58: 128-136. PMID 7643008 DOI: 10.1002/Jlb.58.2.128  0.405
1995 Zhao C, Ganz T, Lehrer RI. The structure of porcine protegrin genes Febs Letters. 368: 197-202. PMID 7628604 DOI: 10.1016/0014-5793(95)00633-K  0.355
1995 Zhao C, Ganz T, Lehrer RI. Structures of genes for two cathelin-associated antimicrobial peptides: prophenin-2 and PR-39 Febs Letters. 376: 130-134. PMID 7498526 DOI: 10.1016/0014-5793(95)01237-3  0.4
1994 Couto MA, Liu L, Lehrer RI, Ganz T. Inhibition of intracellular Histoplasma capsulatum replication by murine macrophages that produce human defensin Infection and Immunity. 62: 2375-2378. PMID 8188361 DOI: 10.1128/Iai.62.6.2375-2378.1994  0.401
1994 Harwig SSL, Ganz T, Lehrer RI. Neutrophil defensins: Purification, characterization, and antimicrobial testing Methods in Enzymology. 236: 160-172. PMID 7968608 DOI: 10.1016/0076-6879(94)36015-4  0.375
1994 Ganz T, Lehrer RI. Defensins Current Opinion in Immunology. 6: 584-589. PMID 7946046 DOI: 10.1097/00006454-198605000-00047  0.413
1994 Panyutich AV, Szold O, Poon PH, Tseng Y, Ganz T. Identification of defensin binding to C1 complement Febs Letters. 356: 169-173. PMID 7805831 DOI: 10.1016/0014-5793(94)01261-X  0.344
1994 Ganz T. Biosynthesis of defensins and other antimicrobial peptides Ciba Foundation Symposium. 186: 62-71; discussion 71. PMID 7768158  0.324
1994 Kagan BL, Ganz T, Lehrer RI. Defensins: a family of antimicrobial and cytotoxic peptides. Toxicology. 87: 131-49. PMID 7512758 DOI: 10.1016/0300-483X(94)90158-9  0.412
1993 Linzmeier R, Michaelson D, Liu L, Ganz T. The structure of neutrophil defensin genes Febs Letters. 321: 267-273. PMID 8477861 DOI: 10.1016/0014-5793(93)80122-B  0.379
1993 Lehrer RI, Lichtenstein AK, Ganz T. Defensins: Antimicrobial and cytotoxic peptides of mammalian cells Annual Review of Immunology. 11: 105-128. PMID 8476558 DOI: 10.1146/Annurev.Iy.11.040193.000541  0.428
1993 Nygaard SD, Ganz T, Peterson MW. Defensins reduce the barrier integrity of a cultured epithelial monolayer without cytotoxicity American Journal of Respiratory Cell and Molecular Biology. 8: 193-200. PMID 8427710 DOI: 10.1165/Ajrcmb/8.2.193  0.39
1993 Panyutich AV, Panyutich EA, Krapivin VA, Baturevich EA, Ganz T. Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis The Journal of Laboratory and Clinical Medicine. 122: 202-207. PMID 8340706 DOI: 10.5555/Uri:Pii:0022214393900587  0.38
1993 Ganz T, Liu L, Valore EV, Oren A. Posttranslational processing and targeting of transgenic human defensin in murine granulocyte, macrophage, fibroblast, and pituitary adenoma cell lines Blood. 82: 641-650. PMID 8329717 DOI: 10.1182/Blood.V82.2.641.Bloodjournal822641  0.382
1993 Linzmeier R, Michaelson D, Liu L, Ganz T. Errata and corrigendaThe structure of neutrophil defensin genes Febs Letters. 326. PMID 8325384 DOI: 10.1016/0014-5793(93)81813-F  0.328
1993 Ganz T. Macrophage function New Horizons (Baltimore, Md.). 1: 23-27. PMID 7922389  0.274
1993 Panyutich AV, Baturevich EA, Kolesnikova TS, Ganz T. The effect of biotinylation on the antigenic specificity of anti-defensin monoclonal antibodies Journal of Immunological Methods. 158: 237-242. PMID 7679133 DOI: 10.1016/0022-1759(93)90219-W  0.346
1992 Michaelson D, Rayner J, Couto M, Ganz T. Cationic defensins arise from charge-neutralized propeptides: A mechanism for avoiding leukocyte autocytotoxicity? Journal of Leukocyte Biology. 51: 634-639. PMID 1613398 DOI: 10.1002/Jlb.51.6.634  0.357
1992 Sherman MP, Ganz T. Host defense in pulmonary alveoli Annual Review of Physiology. 54: 331-350. PMID 1562178 DOI: 10.1146/Annurev.Ph.54.030192.001555  0.34
1992 Ganz T, Oren A, Lehrer RI. Defensins: microbicidal and cytotoxic peptides of mammalian host defense cells Medical Microbiology and Immunology. 181: 99-105. PMID 1406461 DOI: 10.1007/Bf00189428  0.381
1992 Ogata K, Linzer BA, Zuberi RI, Ganz T, Lehrer RI, Catanzaro A. Activity of defensins from human neutrophilic granulocytes against Mycobacterium avium-Mycobacterium intracellulare. Infection and Immunity. 60: 4720-5. PMID 1398982 DOI: 10.1128/Iai.60.11.4720-4725.1992  0.341
1992 Valore EV, Ganz T. Posttranslational processing of defensins in immature human myeloid cells Blood. 79: 1538-1544. PMID 1339298 DOI: 10.1182/Blood.V79.6.1538.Bloodjournal7961538  0.38
1992 Lehrer RI, Ganz T. Defensins: endogenous antibiotic peptides from human leukocytes Ciba Foundation Symposium. 171: 276-290; discussion . PMID 1302183  0.332
1992 Misuno NI, Kolesnikova TS, Lehrer RI, Ganz T, Voitenok NN. Effect of defensin HNP-1 of human neutrophils on production of tumor necrosis factor α by human blood monocytes in vitro Bulletin of Experimental Biology and Medicine. 113: 709-712. DOI: 10.1007/BF00783767  0.244
1991 Borenstein LA, Ganz T, Sell S, Lehrer RI, Miller JN. Contribution of rabbit leukocyte defensins to the host response in experimental syphilis Infection and Immunity. 59: 1368-1377. PMID 2004817 DOI: 10.1128/Iai.59.4.1368-1377.1991  0.364
1991 Lehrer RI, Ganz T, Selsted ME. Defensins: Endogenous antibiotic peptides of animal cells Cell. 64: 229-230. PMID 1988144 DOI: 10.1016/0092-8674(91)90632-9  0.396
1991 Panyutich AV, Voitenok NN, Lehrer RI, Ganz T. An enzyme immunoassay for human defensins Journal of Immunological Methods. 141: 149-155. PMID 1880422 DOI: 10.1016/0022-1759(91)90141-2  0.372
1991 Panyutich A, Ganz T. Activated alpha 2-macroglobulin is a principal defensin-binding protein American Journal of Respiratory Cell and Molecular Biology. 5: 101-106. PMID 1716445 DOI: 10.1165/Ajrcmb/5.2.101  0.362
1990 Burgener R, Wolf M, Ganz T, Baggiolini M. Purification and characterization of a major phosphatidylserine-binding phosphoprotein from human platelets Biochemical Journal. 269: 729-734. PMID 2390065 DOI: 10.1042/Bj2690729  0.342
1990 Okrent DG, Lichtenstein AK, Ganz T. Direct cytotoxicity of polymorphonuclear leukocyte granule proteins to human lung-derived cells and endothelial cells. The American Review of Respiratory Disease. 141: 179-85. PMID 2297176 DOI: 10.1164/Ajrccm/141.1.179  0.389
1990 Lehrer RI, Ganz T. Antimicrobial polypeptides of human neutrophils Blood. 76: 2169-2181. PMID 2257291 DOI: 10.1182/Blood.V76.11.2169.Bloodjournal76112169  0.373
1990 Miyasaki KT, Bodeau AL, Ganz T, Selsted ME, Lehrer RI. In vitro sensitivity of oral, gram-negative, facultative bacteria to the bactericidal activity of human neutrophil defensins. Infection and Immunity. 58: 3934-40. PMID 2254020 DOI: 10.1128/Iai.58.12.3934-3940.1990  0.403
1990 Eisenhauer P, Harwig SSSL, Szklarek D, Ganz T, Lehrer RI. Polymorphic expression of defensins in neutrophils from outbred rats Infection and Immunity. 58: 3899-3902. PMID 2254017 DOI: 10.1128/Iai.58.12.3899-3902.1990  0.34
1990 Saxon A, Shanahan F, Landers C, Ganz T, Targan S. A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease The Journal of Allergy and Clinical Immunology. 86: 202-210. PMID 2200820 DOI: 10.1016/S0091-6749(05)80067-3  0.36
1990 Miyasaki KT, Bodeau AL, Selsted ME, Ganz T, Lehrer RI. Killing of oral, gram-negative, facultative bacteria by the rabbit defensin, NP-1. Oral Microbiology and Immunology. 5: 315-9. PMID 2098709 DOI: 10.1111/J.1399-302X.1990.Tb00432.X  0.392
1990 Kagan BL, Selsted ME, Ganz T, Lehrer RI. Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proceedings of the National Academy of Sciences of the United States of America. 87: 210-4. PMID 1688654 DOI: 10.1073/Pnas.87.1.210  0.381
1989 Chng HH, Ganz T, Saxon A. The utility of detecting of autoantibodies against neutrophil cytoplasmic components in Wegener's granulomatosis Annals of Allergy. 63: 411-416. PMID 2817531  0.248
1989 Sparkes RS, Kronenberg M, Heinzmann C, Daher KA, Klisak I, Ganz T, Mohandas T. Assignment of defensin gene(s) to human chromosome 8p23. Genomics. 5: 240-4. PMID 2793180 DOI: 10.1016/0888-7543(89)90052-9  0.354
1989 Lehrer RI, Barton A, Daher KA, Harwig SSL, Ganz T, Selsted ME. Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity Journal of Clinical Investigation. 84: 553-561. PMID 2668334 DOI: 10.1172/Jci114198  0.383
1989 Territo MC, Ganz T, Selsted ME, Lehrer R. Monocyte-chemotactic activity of defensins from human neutrophils Journal of Clinical Investigation. 84: 2017-2020. PMID 2592571 DOI: 10.1172/Jci114394  0.368
1989 Eisenhauer PB, Harwig SSL, Szklarek D, Ganz T, Selsted ME, Lehrer RI. Purification and antimicrobial properties of three defensins from rat neutrophils Infection and Immunity. 57: 2021-2027. PMID 2543629 DOI: 10.1128/Iai.57.7.2021-2027.1989  0.382
1989 Joiner KA, Ganz T, Albert J, Rotrosen D. The opsonizing ligand on Salmonella typhimurium influences incorporation of specific, but not azurophil, granule constituents into neutrophil phagosomes Journal of Cell Biology. 109: 2771-2782. PMID 2480351 DOI: 10.1083/Jcb.109.6.2771  0.38
1988 Charp PA, Rice WG, Raynor RL, Reimund E, Kinkade JM, Ganz T, Selsted ME, Lehrer RI, Kuo JF. Inhibition of protein kinase C by defensins, antibiotic peptides from human neutrophils. Biochemical Pharmacology. 37: 951-6. PMID 3345204 DOI: 10.1016/0006-2952(88)90187-6  0.27
1988 Lehrer RI, Ganz T, Szklarek D, Selsted ME. Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations Journal of Clinical Investigation. 81: 1829-1835. PMID 3290255 DOI: 10.1172/Jci113527  0.406
1988 Lehrer RI, Ganz T, Selsted ME, Babior BM, Curnutte JT. Neutrophils and host defense Annals of Internal Medicine. 109: 127-142. PMID 3289431 DOI: 10.7326/0003-4819-109-2-127  0.389
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