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Ashwin Unnikrishnan, Ph.D. - Publications

Affiliations: 
2000-2003 Washington University, Saint Louis, St. Louis, MO 
 2004-2009 Basic Sciences Division Fred Hutchinson Cancer Research Center, Seattle, WA, United States 
 2011- Lowy Cancer Research Centre University of New South Wales, Kensington, New South Wales, Australia 
Area:
Molecular Biology, Biochemistry, Cell Biology, Hematopoietic Cancers
Website:
https://powcs.med.unsw.edu.au/node/301300772
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Schnegg-Kaufmann AS, Thoms JAI, Bhuyan GS, Hampton H, Vaughan L, Rutherford KD, Kakadia PM, Lee HM, Johansson EM, Failes TW, Arndt GM, Koval J, Lindeman R, Warburton P, Rodriguez-Meira A, ... ... Unnikrishnan A, et al. Contribution of mutant HSC clones to immature and mature cells in MDS and CMML, and variations with AZA therapy. Blood. PMID 36493342 DOI: 10.1182/blood.2022018602  0.798
2022 Saini SK, Holmberg-Thydén S, Bjerregaard AM, Unnikrishnan A, Dorfmüller S, Platzbecker U, Tirado-Gonzalez I, Bönig H, El Fassi D, Grønbæk K, Pimanda J, Medyouf H, Hadrup SR. Neoantigen reactive T cells correlate with the low mutational burden in hematological malignancies. Leukemia. 36: 2734-2738. PMID 36209321 DOI: 10.1038/s41375-022-01705-y  0.711
2022 John Newton Amaldoss M, Pandzic E, Koshy P, Kumar N, Sorrell CC, Unnikrishnan A. Detection and Quantification of Nanoparticle-Induced Intracellular ROS in Live Cells by Laser Scanning Confocal Microscopy. Methods (San Diego, Calif.). PMID 36028162 DOI: 10.1016/j.ymeth.2022.08.005  0.304
2022 Chandrakanthan V, Rorimpandey P, Zanini F, Chacon D, Olivier J, Joshi S, Kang YC, Knezevic K, Huang Y, Qiao Q, Oliver RA, Unnikrishnan A, Carter DR, Lee B, Brownlee C, et al. Mesoderm-derived PDGFRA cells regulate the emergence of hematopoietic stem cells in the dorsal aorta. Nature Cell Biology. PMID 35902769 DOI: 10.1038/s41556-022-00955-3  0.711
2022 Liu L, Vujovic A, Deshpande NP, Sathe S, Anande G, Chen HTT, Xu J, Minden MD, Yeo GW, Unnikrishnan A, Hope KJ, Lu Y. The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors. Nature Communications. 13: 3833. PMID 35781533 DOI: 10.1038/s41467-022-31155-0  0.785
2022 Amaldoss MJN, Mehmood R, Yang JL, Koshy P, Kumar N, Unnikrishnan A, Sorrell CC. Anticancer therapeutic effect of cerium-based nanoparticles: known and unknown molecular mechanisms. Biomaterials Science. PMID 35686620 DOI: 10.1039/d2bm00334a  0.349
2022 Liu YC, Kwon J, Fabiani E, Xiao Z, Liu YV, Follo MY, Liu J, Huang H, Gao C, Liu J, Falconi G, Valentini L, Gurnari C, Finelli C, Cocco L, ... ... Unnikrishnan A, et al. Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy. The New England Journal of Medicine. 386: 1998-2010. PMID 35613022 DOI: 10.1056/NEJMoa2119771  0.692
2021 Yang J, Gao C, Liu M, Liu YC, Kwon J, Qi J, Tian X, Stein A, Liu YV, Kong NR, Wu Y, Yin S, Xi J, Chen Z, Kumari K, ... ... Unnikrishnan A, et al. Targeting an inducible SALL4-mediated cancer vulnerability with sequential therapy. Cancer Research. PMID 34593523 DOI: 10.1158/0008-5472.CAN-21-0030  0.708
2021 Lorenzi L, Chiu HS, Avila Cobos F, Gross S, Volders PJ, Cannoodt R, Nuytens J, Vanderheyden K, Anckaert J, Lefever S, Tay AP, de Bony EJ, Trypsteen W, Gysens F, Vromman M, ... ... Unnikrishnan A, et al. Publisher Correction: The RNA Atlas expands the catalog of human non-coding RNAs. Nature Biotechnology. PMID 34183863 DOI: 10.1038/s41587-021-00996-3  0.752
2021 Lorenzi L, Chiu HS, Avila Cobos F, Gross S, Volders PJ, Cannoodt R, Nuytens J, Vanderheyden K, Anckaert J, Lefever S, Tay AP, de Bony EJ, Trypsteen W, Gysens F, Vromman M, ... ... Unnikrishnan A, et al. The RNA Atlas expands the catalog of human non-coding RNAs. Nature Biotechnology. PMID 34140680 DOI: 10.1038/s41587-021-00936-1  0.764
2020 Saini SK, Ørskov AD, Bjerregaard AM, Unnikrishnan A, Holmberg-Thydén S, Borch A, Jensen KV, Anande G, Bentzen AK, Marquard AM, Tamhane T, Treppendahl MB, Gang AO, Dufva IH, Szallasi Z, et al. Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers. Nature Communications. 11: 5660. PMID 33168830 DOI: 10.1038/s41467-020-19464-8  0.767
2020 Anande G, Deshpande NP, Mareschal S, Batcha AMN, Hampton HR, Herold T, Lehmann S, Wilkins MR, Wong JWH, Unnikrishnan A, Pimanda JE. RNA splicing alterations induce a cellular stress response associated with poor prognosis in Acute Myeloid Leukemia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32122925 DOI: 10.1158/1078-0432.Ccr-20-0184  0.773
2020 Khanna A, Thoms JAI, Stringer BW, Chung SA, Ensbey KS, Jue TR, Jahan Z, Subramanian S, Anande G, Shen H, Unnikrishnan A, McDonald KL, Day BW, Pimanda JE. Constitutive CHK1 expression drives a pSTAT3-CIP2A circuit that promotes glioblastoma cell survival and growth. Molecular Cancer Research : McR. PMID 32079743 DOI: 10.1158/1541-7786.Mcr-19-0934  0.767
2019 Kumar P, Beck D, Galeev R, Thoms JAI, Talkhoncheh MS, de Jong I, Unnikrishnan A, Baudet A, Subramaniam A, Pimanda JE, Larsson J. HMGA2 promotes long-term engraftment and myeloerythroid differentiation of human hematopoietic stem and progenitor cells. Blood Advances. 3: 681-691. PMID 30808686 DOI: 10.1182/Bloodadvances.2018023986  0.768
2019 Anande G, Unnikrishnan A, Deshpande N, Mareschal S, Batcha AMN, Herold T, Lehmann S, Wilkins M, Wong J, Pimanda J. Identification of Recurrent Alternative RNA Splicing in Adverse-Risk Acute Myeloid Leukemia Blood. 134: 457-457. DOI: 10.1182/Blood-2019-129537  0.769
2019 Unnikrishnan A, Lim XY, Joshi S, Nunez AC, Vaughan L, Pickford R, Hough S, Davidson S, Fong C, Kenealy M, Hiwase DK, Pasalic L, Mohammed S, Lee L, Passam FH, et al. In Vivo Assessment of Intracellular Dynamics Comparing Injection Versus Oral Azacitidine in a Phase IIb Investigator Initiated Clinical Trial Blood. 134: 4247-4247. DOI: 10.1182/Blood-2019-123921  0.767
2018 Smeets MF, Tan SY, Xu JJ, Anande G, Unnikrishnan A, Chalk AM, Taylor SR, Pimanda JE, Wall M, Purton LE, Walkley CR. initiates myeloid bias and myelodysplastic/myeloproliferative syndrome (MDS/MPN) from hemopoietic stem cells. Blood. PMID 29903888 DOI: 10.1182/Blood-2018-04-845602  0.766
2018 Ali A, Penneroux J, Dal Bello R, Massé A, Quentin S, Unnikrishnan A, Hernandez L, Raffoux E, Ben Abdelali R, Renneville A, Preudhomme C, Pimanda J, Dombret H, Soulier J, Fenaux P, et al. Granulomonocytic progenitors are key target cells of azacytidine in higher risk myelodysplastic syndromes and acute myeloid leukemia. Leukemia. PMID 29535430 DOI: 10.1038/S41375-018-0076-2  0.72
2018 Sonderegger S, Cerruti L, Tremblay C, Toulmin E, Saw J, Nebl T, Hannan KM, Lane SW, Falk H, Unnikrishnan A, Stupple P, Street I, Jane S, Altura R, Nicholson B, et al. Small-Molecule Inhibition of PRMT5 Induces Translational Stress and p53 in JAK2V617F Mutant Myeloproliferative Neoplasms Blood. 132: 53-53. DOI: 10.1182/Blood-2018-99-118406  0.405
2017 Unnikrishnan A, Vo ANQ, Pickford R, Raftery MJ, Nunez AC, Verma A, Hesson LB, Pimanda JE. AZA-MS: a novel multiparameter mass spectrometry method to determine the intracellular dynamics of azacitidine therapy in vivo. Leukemia. PMID 29249821 DOI: 10.1038/Leu.2017.340  0.318
2017 Unnikrishnan A, Papaemmanuil E, Beck D, Deshpande NP, Verma A, Kumari A, Woll PS, Richards LA, Knezevic K, Chandrakanthan V, Thoms JAI, Tursky ML, Huang Y, Ali Z, Olivier J, et al. Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes. Cell Reports. 20: 572-585. PMID 28723562 DOI: 10.1016/J.Celrep.2017.06.067  0.787
2017 Chandrakanthan V, Kang YC, Knezevic K, Qiao Q, Oliver RA, Unnikrishnan A, Beck D, Lee B, Brownlee C, Power C, Pimanda JE. Genetic Fate Mapping of Mesenchymal Stem-Like Cells in the Aorta-Gonad Mesonephros (AGM) and Their Contribution to Definitive Hematopoiesis Mechanisms of Development. 145: S55-S56. DOI: 10.1016/J.Mod.2017.04.109  0.305
2017 Chandrakanthan V, Kang YC, Knezevic K, Qiao Q, Oliver R, Unnikrishnan A, Huang Y, Walsh W, Lee B, Lee CB, Power C, Beck D, Taoudi S, Pimanda J. Declined presentation mesenchymal stem cell-like cell mediated hematopoietic stem cell generation from non-hemogenic endothelial cells Experimental Hematology. 53. DOI: 10.1016/J.Exphem.2017.06.296  0.732
2016 Poulos RC, Thoms JA, Guan YF, Unnikrishnan A, Pimanda JE, Wong JW. Functional Mutations Form at CTCF-Cohesin Binding Sites in Melanoma Due to Uneven Nucleotide Excision Repair across the Motif. Cell Reports. 17: 2865-2872. PMID 27974201 DOI: 10.1016/J.Celrep.2016.11.055  0.774
2016 Unnikrishnan A, Guan YF, Huang Y, Beck D, Thoms JA, Peirs S, Knezevic K, Ma S, de Walle IV, de Jong I, Ali Z, Zhong L, Raftery MJ, Taghon T, Larsson J, et al. A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network. Nucleic Acids Research. PMID 27604872 DOI: 10.1093/Nar/Gkw804  0.8
2016 Nasrallah R, Fast EM, Solaimani P, Knezevic K, Eliades A, Patel R, Thambyrajah R, Unnikrishnan A, Thoms J, Beck D, Vink CS, Smith A, Wong J, Shepherd M, Kent D, et al. Identification of novel regulators of developmental hematopoiesis using endoglin regulatory elements as molecular probes. Blood. PMID 27554085 DOI: 10.1182/Blood-2016-02-697870  0.799
2016 Botezatu L, Michel LC, Makishima H, Schroeder T, Germing U, Haas R, van der Reijden B, Marneth AE, Bergevoet SM, Jansen JH, Przychodzen B, Wlodarski M, Niemeyer C, Platzbecker U, Ehninger G, ... Unnikrishnan A, et al. GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndrome (MDS). Experimental Hematology. PMID 27080012 DOI: 10.1016/J.Exphem.2016.04.001  0.724
2016 Chandrakanthan V, Yeola A, Kwan JC, Oliver RA, Qiao Q, Kang YC, Zarzour P, Beck D, Boelen L, Unnikrishnan A, Villanueva JE, Nunez AC, Knezevic K, Palu C, Nasrallah R, et al. PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 27044077 DOI: 10.1073/Pnas.1518244113  0.775
2015 Tursky ML, Beck D, Thoms JA, Huang Y, Kumari A, Unnikrishnan A, Knezevic K, Evans K, Richards LA, Lee E, Morris J, Goldberg L, Izraeli S, Wong JW, Olivier J, et al. Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias. Leukemia. 29: 819-27. PMID 25306899 DOI: 10.1038/Leu.2014.299  0.819
2015 Unnikrishnan A, Papaemmanuil E, Beck D, Verma A, Kumari A, Richards LA, Knezevic K, Chandrakanthan V, Thoms JA, Tursky ML, Huang Y, Galbraith S, Kulasekararaj AG, Tobiasson M, Woll PS, et al. An Integrative Genomics Approach Uncovers the Basis of Resistance to AZA Therapy in MDS and CMML Blood. 126: 710-710. DOI: 10.1182/Blood.V126.23.710.710  0.624
2015 Lacramioara B, Makishima H, Michel L, Hoenes J, Marneth A, van der Reijden B, Radiovoyevich T, Germing U, Haas R, Schroeder T, Vadnais C, Helness A, Pimanda J, Jansen J, Unnikrishnan A, et al. 72 PERSONALIZED TREATMENT APPROACH FOR GFI136N HETEROZYGOUS OR HOMOZYGOUS MDS PATIENTS Leukemia Research. 39: S35. DOI: 10.1016/S0145-2126(15)30073-4  0.686
2015 Woll P, Kjällquist U, Chowdhury O, Doolittle H, Wedge D, Thongjuea S, Erlandsson R, Ngara M, Anderson K, Deng Q, Mead A, Stenson L, Giustacchini A, Duarte S, Giannoulatou E, ... ... Unnikrishnan A, et al. Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo Cancer Cell. 27: 603-605. DOI: 10.1016/J.Ccell.2015.03.003  0.35
2014 Ju YS, Alexandrov LB, Gerstung M, Martincorena I, Nik-Zainal S, Ramakrishna M, Davies HR, Papaemmanuil E, Gundem G, Shlien A, Bolli N, Behjati S, Tarpey PS, Nangalia J, Massie CE, ... ... Unnikrishnan A, et al. Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer. Elife. 3. PMID 25271376 DOI: 10.7554/Elife.02935  0.731
2014 Woll PS, Kjällquist U, Chowdhury O, Doolittle H, Wedge DC, Thongjuea S, Erlandsson R, Ngara M, Anderson K, Deng Q, Mead AJ, Stenson L, Giustacchini A, Duarte S, Giannoulatou E, ... ... Unnikrishnan A, et al. Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo. Cancer Cell. 25: 794-808. PMID 24835589 DOI: 10.1016/J.Ccr.2014.03.036  0.747
2014 Tobiasson M, Karimi M, Dimitriou M, Qu Y, Lennartsson A, Abdulkadir Ali H, Unnikrishnan A, Jadersten M, Jansson M, Ben Azenkoud A, Pimanda JE, Ekwall K, Ungerstedt J, Lehmann S, Hellstrom-Lindberg E. Mutations in Histone Modulators and HOXA5 Methylation Levels Affects Survival in Azacitidine Treated MDS Patients Blood. 124: 4613-4613. DOI: 10.1182/Blood.V124.21.4613.4613  0.399
2014 Unnikrishnan A, Beck D, Verma A, Richards LA, Thoms JAI, Kumari A, Galbraith S, Kulasekararaj A, Tobiasson M, Woll PS, Pellagatti A, Papaemmanuil E, Wilson SR, Lindeman R, Campbell PJ, et al. Identification of a Prognostic Gene Expression Signature for AZA Response in MDS and CMML Patients Blood. 124: 4601-4601. DOI: 10.1182/Blood.V124.21.4601.4601  0.4
2013 Beck D, Thoms JA, Perera D, Schütte J, Unnikrishnan A, Knezevic K, Kinston SJ, Wilson NK, O'Brien TA, Göttgens B, Wong JW, Pimanda JE. Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes. Blood. 122: e12-22. PMID 23974199 DOI: 10.1182/Blood-2013-03-490425  0.802
2012 Beck D, Brandl MB, Boelen L, Unnikrishnan A, Pimanda JE, Wong JW. Signal analysis for genome-wide maps of histone modifications measured by ChIP-seq. Bioinformatics (Oxford, England). 28: 1062-9. PMID 22345622 DOI: 10.1093/Bioinformatics/Bts085  0.764
2012 Unnikrishnan A, Akiyoshi B, Biggins S, Tsukiyama T. An efficient purification system for native minichromosome from saccharomyces cerevisiae Methods in Molecular Biology. 833: 115-123. PMID 22183591 DOI: 10.1007/978-1-61779-477-3_8  0.542
2010 Unnikrishnan A, Gafken PR, Tsukiyama T. Dynamic changes in histone acetylation regulate origins of DNA replication. Nature Structural & Molecular Biology. 17: 430-7. PMID 20228802 DOI: 10.1038/Nsmb.1780  0.542
2010 Tsukiyama T, Bogenschutz N, Kwong T, Rodriguez J, Unnikrishnan A, Yadon A. ISWI chromatin remodeling complexes Handbook of Cell Signaling, 2/E. 3: 2357-2362. DOI: 10.1016/B978-0-12-374145-5.00283-7  0.76
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