☰

cached image

Neil L. Kelleher, Ph.D. - Publications

Affiliations: 
Molecular Biosciences, Chemistry Department, and Feinberg School of Medicine Northwestern University, Evanston, IL 
Website:
http://en.wikipedia.org/wiki/Neil_Kelleher_%28scientist%29
Tree Info Similar researchers PubMed Report error

387 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Drown BS, Gupta R, McGee JP, Hollas MAR, Hergenrother PJ, Kafader JO, Kelleher NL. Precise Readout of MEK1 Proteoforms upon MAPK Pathway Modulation by Individual Ion Mass Spectrometry. Analytical Chemistry. PMID 38458998 DOI: 10.1021/acs.analchem.3c04758  0.573
2023 Kandi S, Cline EN, Rivera BM, Viola KL, Zhu J, Condello C, LeDuc RD, Klein WL, Kelleher NL, Patrie SM. Amyloid β Proteoforms Elucidated by Quantitative LC/MS in the 5xFAD Mouse Model of Alzheimer's Disease. Journal of Proteome Research. 22: 3475-3488. PMID 37847596 DOI: 10.1021/acs.jproteome.3c00353  0.666
2023 Robey MT, Utley D, Greer JB, Fellers RT, Kelleher NL, Durbin KR. Advancing Intact Protein Quantitation with Updated Deconvolution Routines. Analytical Chemistry. 95: 14954-14962. PMID 37750863 DOI: 10.1021/acs.analchem.3c02345  0.325
2023 Lermyte F, Habeck T, Brown K, Des Soye B, Lantz C, Zhou M, Alam N, Hossain MA, Jung W, Keener J, Volny M, Wilson J, Ying Y, Agar J, Danis P, ... ... Kelleher N, et al. Top-down mass spectrometry of native proteoforms and their complexes: A community study. Research Square. PMID 37674709 DOI: 10.21203/rs.3.rs-3228472/v1  0.651
2023 Durbin KR, Robey MT, Voong LN, Fellers RT, Lutomski CA, El-Baba TJ, Robinson CV, Kelleher NL. ProSight Native: Defining Protein Complex Composition from Native Top-Down Mass Spectrometry Data. Journal of Proteome Research. PMID 37436406 DOI: 10.1021/acs.jproteome.3c00171  0.314
2023 Faizi M, Fellers RT, Lu D, Drown BS, Jambhekar A, Lahav G, Kelleher NL, Gunawardena J. MSModDetector: A Tool for Detecting Mass Shifts and Post-Translational Modifications in Individual Ion Mass Spectrometry Data. Biorxiv : the Preprint Server For Biology. PMID 37333327 DOI: 10.1101/2023.06.06.543961  0.802
2023 Caesar LK, Butun FA, Robey MT, Ayon NJ, Gupta R, Dainko D, Bok JW, Nickles G, Stankey RJ, Johnson D, Mead D, Cank KB, Earp CE, Raja HA, Oberlies NH, ... ... Kelleher NL, et al. Correlative metabologenomics of 110 fungi reveals metabolite-gene cluster pairs. Nature Chemical Biology. PMID 36879060 DOI: 10.1038/s41589-023-01276-8  0.763
2022 Ives AN, Dunn HA, Afsari HS, Seckler HDS, Foroutan MJ, Chavez E, Melani RD, Fellers RT, LeDuc RD, Thomas PM, Martemyanov KA, Kelleher NL, Vafabakhsh R. Middle-Down Mass Spectrometry Reveals Activity-Modifying Phosphorylation Barcode in a Class C G Protein-Coupled Receptor. Journal of the American Chemical Society. PMID 36475650 DOI: 10.1021/jacs.2c10697  0.438
2022 Adams LM, DeHart CJ, Drown BS, Anderson LC, Bocik W, Boja ES, Hiltke TM, Hendrickson CL, Rodriguez H, Caldwell M, Vafabakhsh R, Kelleher NL. Mapping the KRAS Proteoform Landscape in Colorectal Cancer Identifies Truncated KRAS4B that Decreases MAPK Signaling. The Journal of Biological Chemistry. 102768. PMID 36470426 DOI: 10.1016/j.jbc.2022.102768  0.723
2022 Su P, McGee JP, Durbin KR, Hollas MAR, Yang M, Neumann EK, Allen JL, Drown BS, Butun FA, Greer JB, Early BP, Fellers RT, Spraggins JM, Laskin J, Camarillo JM, ... ... Kelleher NL, et al. Highly multiplexed, label-free proteoform imaging of tissues by individual ion mass spectrometry. Science Advances. 8: eabp9929. PMID 35947651 DOI: 10.1126/sciadv.abp9929  0.754
2022 Jooß K, McGee JP, Kelleher NL. Native Mass Spectrometry at the Convergence of Structural Biology and Compositional Proteomics. Accounts of Chemical Research. PMID 35749283 DOI: 10.1021/acs.accounts.2c00216  0.342
2022 Yang M, Hu H, Su P, Thomas PM, Camarillo JM, Greer JB, Early BP, Fellers RT, Kelleher NL, Laskin J. Proteoform-Selective Imaging of Tissues Using Mass Spectrometry. Angewandte Chemie (International Ed. in English). PMID 35446460 DOI: 10.1002/anie.202200721  0.48
2022 Drown BS, Jooß K, Melani RD, Lloyd-Jones C, Camarillo JM, Kelleher NL. Mapping the Proteoform Landscape of Five Human Tissues. Journal of Proteome Research. PMID 35413190 DOI: 10.1021/acs.jproteome.2c00034  0.771
2022 Park YJ, Jodts RJ, Slater JW, Reyes RM, Winton VJ, Montaser RA, Thomas PM, Dowdle WB, Ruiz A, Kelleher NL, Bollinger JM, Krebs C, Hoffman BM, Rosenzweig AC. A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 119: e2123566119. PMID 35320042 DOI: 10.1073/pnas.2123566119  0.616
2022 LeDuc RD, Deutsch EW, Binz PA, Fellers RT, Cesnik AJ, Klein JA, Van Den Bossche T, Gabriels R, Yalavarthi A, Perez-Riverol Y, Carver J, Bittremieux W, Kawano S, Pullman B, Bandeira N, ... Kelleher NL, et al. Proteomics Standards Initiative's ProForma 2.0: Unifying the Encoding of Proteoforms and Peptidoforms. Journal of Proteome Research. PMID 35290070 DOI: 10.1021/acs.jproteome.1c00771  0.537
2022 Greer JB, Early BP, Durbin KR, Patrie SM, Thomas PM, Kelleher NL, LeDuc RD, Fellers RT. ProSight Annotator: Complete control and customization of protein entries in UniProt XML files. Proteomics. e2100209. PMID 35286768 DOI: 10.1002/pmic.202100209  0.731
2022 Bartley SC, Proctor MT, Xia H, Ho E, Kang DS, Schuster K, Bicca MA, Seckler HS, Viola KL, Patrie SM, Kelleher NL, De Mello FG, Klein WL. An Essential Role for Alzheimer's-Linked Amyloid Beta Oligomers in Neurodevelopment: Transient Expression of Multiple Proteoforms during Retina Histogenesis. International Journal of Molecular Sciences. 23. PMID 35216328 DOI: 10.3390/ijms23042208  0.66
2022 Melani RD, Gerbasi VR, Anderson LC, Sikora JW, Toby TK, Hutton JE, Butcher DS, Negrão F, Seckler HS, Srzentić K, Fornelli L, Camarillo JM, LeDuc RD, Cesnik AJ, Lundberg E, ... ... Kelleher NL, et al. The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells. Science (New York, N.Y.). 375: 411-418. PMID 35084980 DOI: 10.1126/science.aaz5284  0.443
2022 Hollas MAR, Robey MT, Fellers RT, LeDuc RD, Thomas PM, Kelleher NL. The Human Proteoform Atlas: a FAIR community resource for experimentally derived proteoforms. Nucleic Acids Research. 50: D526-D533. PMID 34986596 DOI: 10.1093/nar/gkab1086  0.453
2021 Melani RD, Des Soye BJ, Kafader JO, Forte E, Hollas M, Blagojevic V, Negrão F, McGee JP, Drown B, Lloyd-Jones C, Seckler HS, Camarillo JM, Compton PD, LeDuc RD, Early B, ... ... Kelleher NL, et al. Next-Generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire. Journal of Proteome Research. PMID 34878788 DOI: 10.1021/acs.jproteome.1c00882  0.784
2021 Smith LM, Agar JN, Chamot-Rooke J, Danis PO, Ge Y, Loo JA, Paša-Tolić L, Tsybin YO, Kelleher NL. The Human Proteoform Project: Defining the human proteome. Science Advances. 7: eabk0734. PMID 34767442 DOI: 10.1126/sciadv.abk0734  0.527
2021 Schachner LF, Tran DP, Lee A, McGee JP, Jooss K, Durbin K, Seckler HDS, Adams L, Cline E, Melani R, Ives AN, Des Soye B, Kelleher NL, Patrie SM. Reassembling protein complexes after controlled disassembly by top-down mass spectrometry in native mode. International Journal of Mass Spectrometry. 465. PMID 34539228 DOI: 10.1016/j.ijms.2021.116591  0.733
2021 Park YJ, Roberts GM, Montaser R, Kenney GE, Thomas PM, Kelleher NL, Rosenzweig AC. Characterization of a Copper-Chelating Natural Product from the Methanotroph sp. LW3. Biochemistry. PMID 34510894 DOI: 10.1021/acs.biochem.1c00443  0.467
2021 Melani RD, Soye BJD, Kafader JO, Forte E, Hollas M, Blagojevic V, Negrão F, McGee JP, Drown B, Lloyd-Jones C, Seckler HS, Camarillo JM, Compton PD, LeDuc RD, Early B, ... ... Kelleher NL, et al. Next-generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire. Medrxiv : the Preprint Server For Health Sciences. PMID 34268518 DOI: 10.1101/2021.07.06.21259226  0.79
2021 Doubleday PF, Fornelli L, Ntai I, Kelleher NL. Oncogenic KRAS creates an aspartate metabolism signature in colorectal cancer cells. The Febs Journal. PMID 34227245 DOI: 10.1111/febs.16111  0.637
2021 Santos Seckler HD, Park HM, Lloyd-Jones CM, Melani RD, Camarillo JM, Wilkins JT, Compton PD, Kelleher NL. New Interface for Faster Proteoform Analysis: Immunoprecipitation Coupled with SampleStream-Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 34043341 DOI: 10.1021/jasms.1c00026  0.301
2021 Adams LM, DeHart CJ, Kelleher NL. Precise Characterization of KRAS4B Proteoforms by Combining Immunoprecipitation with Top-Down Mass Spectrometry. Methods in Molecular Biology (Clifton, N.J.). 2262: 47-64. PMID 33977470 DOI: 10.1007/978-1-0716-1190-6_3  0.323
2021 Gerbasi VR, Melani RD, Abbatiello SE, Belford MW, Huguet R, McGee JP, Dayhoff D, Thomas PM, Kelleher NL. Deeper Protein Identification Using Field Asymmetric Ion Mobility Spectrometry in Top-Down Proteomics. Analytical Chemistry. PMID 33844503 DOI: 10.1021/acs.analchem.1c00402  0.538
2021 Schorn MA, Verhoeven S, Ridder L, Huber F, Acharya DD, Aksenov AA, Aleti G, Moghaddam JA, Aron AT, Aziz S, Bauermeister A, Bauman KD, Baunach M, Beemelmanns C, Beman JM, ... ... Kelleher NL, et al. A community resource for paired genomic and metabolomic data mining. Nature Chemical Biology. PMID 33589842 DOI: 10.1038/s41589-020-00724-z  0.757
2021 Jooß K, McGee JP, Melani RD, Kelleher NL. Standard procedures for native CZE-MS of proteins and protein complexes up to 800 kDa. Electrophoresis. 42: 1050-1059. PMID 33502026 DOI: 10.1002/elps.202000317  0.355
2021 Liu Y, Davis RG, Thomas PM, Kelleher NL, Jewett MC. -Constructed Ribosomes Enable Multi-site Incorporation of Noncanonical Amino Acids into Proteins. Biochemistry. PMID 33426883 DOI: 10.1021/acs.biochem.0c00829  0.533
2020 Parsa S, Ortega-Molina A, Ying HY, Jiang M, Teater M, Wang J, Zhao C, Reznik E, Pasion JP, Kuo D, Mohan P, Wang S, Camarillo JM, Thomas PM, Jain N, ... ... Kelleher NL, et al. The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing. Nature Cancer. 1: 653-664. PMID 33569544 DOI: 10.1038/s43018-020-0080-0  0.413
2020 McGee JP, Melani RD, Yip PF, Senko MW, Compton PD, Kafader JO, Kelleher NL. Isotopic Resolution of Protein Complexes up to 466 kDa Using Individual Ion Mass Spectrometry. Analytical Chemistry. PMID 33322893 DOI: 10.1021/acs.analchem.0c03282  0.324
2020 An S, Camarillo JM, Huang TY, Li D, Morris JA, Zoltek MA, Qi J, Behbahani M, Kambhampati M, Kelleher NL, Nazarian J, Thomas PM, Saratsis AM. Histone tail analysis reveals H3K36me2 and H4K16ac as epigenetic signatures of diffuse intrinsic pontine glioma. Journal of Experimental & Clinical Cancer Research : Cr. 39: 261. PMID 33239043 DOI: 10.1186/s13046-020-01773-x  0.4
2020 Hamm PS, Dunlap CA, Mullowney MW, Caimi NA, Kelleher NL, Thomson RJ, Porras-Alfaro A, Northup DE. Streptomyces buecherae sp. nov., an actinomycete isolated from multiple bat species. Antonie Van Leeuwenhoek. PMID 33200278 DOI: 10.1007/s10482-020-01493-4  0.77
2020 Tryon JH, Rote JC, Chen L, Robey MT, Vega MM, Phua WC, Metcalf WW, Ju KS, Kelleher NL, Thomson RJ. Genome Mining and Metabolomics Uncover a Rare d-Capreomycidine Containing Natural Product and Its Biosynthetic Gene Cluster. Acs Chemical Biology. PMID 33151679 DOI: 10.1021/acschembio.0c00663  0.474
2020 Abshiru NA, Sikora JW, Camarillo JM, Morris JA, Compton PD, Lee T, Neelamraju Y, Haddox S, Sheridan C, Carroll M, Cripe LD, Tallman MS, Paietta EM, Melnick AM, Thomas PM, ... ... Kelleher NL, et al. Targeted detection and quantitation of histone modifications from 1,000 cells. Plos One. 15: e0240829. PMID 33104722 DOI: 10.1371/journal.pone.0240829  0.477
2020 Deighan WI, Winton VJ, Melani RD, Anderson LC, McGee JP, Schachner LF, Barnidge D, Murray D, Alexander HD, Gibson DS, Deery MJ, McNicholl FP, McLaughlin J, Kelleher NL, Thomas PM. Development of novel methods for non-canonical myeloma protein analysis with an innovative adaptation of immunofixation electrophoresis, native top-down mass spectrometry, and middle-down de novo sequencing. Clinical Chemistry and Laboratory Medicine. PMID 33079696 DOI: 10.1515/cclm-2020-1072  0.557
2020 Caesar LK, Robey MT, Swyers M, Islam MN, Ye R, Vagadia PP, Schiltz GE, Thomas PM, Wu CC, Kelleher NL, Keller NP, Bok JW. Heterologous Expression of the Unusual Terreazepine Biosynthetic Gene Cluster Reveals a Promising Approach for Identifying New Chemical Scaffolds. Mbio. 11. PMID 32843555 DOI: 10.1128/Mbio.01691-20  0.507
2020 Srzentić K, Fornelli L, Tsybin YO, Loo JA, Seckler H, Agar JN, Anderson LC, Bai DL, Beck A, Brodbelt JS, van der Burgt YEM, Chamot-Rooke J, Chatterjee S, Chen Y, Clarke DJ, ... ... Kelleher NL, et al. Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 32812765 DOI: 10.1021/Jasms.0C00036  0.819
2020 Ives A, Su T, Durbin KR, Early BP, Dos Santos Seckler H, Fellers RT, LeDuc RD, Schachner LF, Patrie SM, Kelleher NL. Using 10,000 fragment ions to inform scoring in native top-down proteomics. Journal of the American Society For Mass Spectrometry. PMID 32436704 DOI: 10.1021/Jasms.0C00026  0.744
2020 McGee JP, Melani RD, Goodwin M, McAlister G, Huguet R, Senko MW, Compton PD, Kelleher NL. Voltage Rollercoaster Filtering of Low-Mass Contaminants During Native Protein Analysis. Journal of the American Society For Mass Spectrometry. 31: 763-767. PMID 32126774 DOI: 10.1021/Jasms.9B00037  0.401
2020 Kafader JO, Melani RD, Durbin KR, Ikwuagwu B, Early BP, Fellers RT, Beu SC, Zabrouskov V, Makarov AA, Maze JT, Shinholt DL, Yip PF, Tullman-Ercek D, Senko MW, Compton PD, ... Kelleher NL, et al. Multiplexed mass spectrometry of individual ions improves measurement of proteoforms and their complexes. Nature Methods. PMID 32123391 DOI: 10.1038/S41592-020-0764-5  0.344
2020 Zhu W, Doubleday PF, Catlin DS, Weerawarna PM, Butrin A, Shen S, Wawrzak Z, Kelleher NL, Liu D, Silverman RB. A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid. Journal of the American Chemical Society. PMID 32114761 DOI: 10.1021/Jacs.0C00193  0.362
2020 Kosciuk T, Price IR, Zhang X, Zhu C, Johnson KN, Zhang S, Halaby SL, Komaniecki GP, Yang M, DeHart CJ, Thomas PM, Kelleher NL, Christopher Fromme J, Lin H. NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. Nature Communications. 11: 1067. PMID 32103017 DOI: 10.1038/S41467-020-14893-X  0.65
2020 Kafader JO, Durbin KR, Melani RD, Des Soye BJ, Schachner LF, Senko MW, Compton PD, Kelleher NL. Individual Ion Mass Spectrometry Enhances the Sensitivity and Sequence Coverage of Top-Down Mass Spectrometry. Journal of Proteome Research. PMID 32032494 DOI: 10.1021/Acs.Jproteome.9B00797  0.415
2020 Kafader JO, Melani RD, Schachner LF, Ives A, Patrie SM, Kelleher NL, Compton PD. Native vs Denatured: An in Depth Investigation of Charge State and Isotope Distributions. Journal of the American Society For Mass Spectrometry. PMID 31971796 DOI: 10.1021/Jasms.9B00040  0.735
2020 Doubleday PF, Fornelli L, Kelleher NL. Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype. Journal of Proteome Research. 19: 938-948. PMID 31940439 DOI: 10.1021/Acs.Jproteome.9B00739  0.37
2020 Winer B, Edgel KA, Zou X, Sellau J, Hadiwidjojo S, Garver LS, McDonough CE, Kelleher NL, Thomas PM, Villasante E, Ploss A, Gerbasi VR. Identification of Plasmodium falciparum proteoforms from liver stage models. Malaria Journal. 19: 10. PMID 31910830 DOI: 10.1186/S12936-019-3093-3  0.445
2020 DeHart CJ, Anderson LC, Adams LM, Fornelli L, Hendrickson CL, Kelleher NL. Abstract A26: Precise characterization and comparison of KRAS proteoforms by top-down mass spectrometry Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Ras18-A26  0.416
2019 Fornelli L, Srzentić K, Toby TK, Doubleday PF, Huguet R, Mullen C, Melani RD, Dos Santos Seckler H, DeHart CJ, Weisbrod CR, Durbin KR, Greer JB, Early BP, Fellers RT, Zabrouskov V, ... ... Kelleher NL, et al. Thorough performance evaluation of 213 nm ultraviolet photodissociation for top-down proteomics. Molecular & Cellular Proteomics : McP. PMID 31888965 DOI: 10.1074/Mcp.Tir119.001638  0.541
2019 Montaser R, Kelleher NL. Discovery of the Biosynthetic Machinery for the Stravidins, Biotin Antimetabolites. Acs Chemical Biology. PMID 31887014 DOI: 10.1021/Acschembio.9B00890  0.351
2019 Park HM, Winton VJ, Drader JJ, Manalili Wheeler S, Lazar GA, Kelleher NL, Liu Y, Tran JC, Compton PD. A Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry. Analytical Chemistry. PMID 31880920 DOI: 10.1021/Acs.Analchem.9B04826  0.411
2019 Navarro-Muñoz JC, Selem-Mojica N, Mullowney MW, Kautsar SA, Tryon JH, Parkinson EI, De Los Santos ELC, Yeong M, Cruz-Morales P, Abubucker S, Roeters A, Lokhorst W, Fernandez-Guerra A, Cappelini LTD, Goering AW, ... ... Kelleher NL, et al. A computational framework to explore large-scale biosynthetic diversity. Nature Chemical Biology. PMID 31768033 DOI: 10.1038/S41589-019-0400-9  0.78
2019 Huguet R, Mullen C, Srzentić K, Greer JB, Fellers RT, Zabrouskov V, Syka JE, Kelleher NL, Fornelli L. Proton transfer charge reduction enables high-throughput top-down analysis of large proteoforms. Analytical Chemistry. PMID 31714757 DOI: 10.1021/Acs.Analchem.9B03925  0.368
2019 Des Soye BJ, Gerbasi VR, Thomas PM, Kelleher NL, Jewett MC. A Highly Productive, One-Pot Cell-Free Protein Synthesis Platform Based on Genomically Recoded Escherichia coli. Cell Chemical Biology. PMID 31706984 DOI: 10.1016/J.Chembiol.2019.10.008  0.563
2019 Melani RD, Srzentić K, Gerbasi VR, McGee JP, Huguet R, Fornelli L, Kelleher NL. Direct measurement of light and heavy antibody chains using ion mobility and middle-down mass spectrometry. Mabs. 11: 1351-1357. PMID 31607219 DOI: 10.1080/19420862.2019.1668226  0.384
2019 Park HM, Satta R, Davis RG, Goo YA, LeDuc RD, Fellers RT, Greer JB, Romanova EV, Rubakhin SS, Tai R, Thomas PM, Sweedler JV, Kelleher NL, Patrie SM, Lasek AW. Multidimensional Top-Down Proteomics of Brain Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol. Journal of Proteome Research. PMID 31550894 DOI: 10.1021/Acs.Jproteome.9B00481  0.708
2019 Smith LM, Thomas PM, Shortreed MR, Schaffer LV, Fellers RT, LeDuc RD, Tucholski T, Ge Y, Agar JN, Anderson LC, Chamot-Rooke J, Gault J, Loo JA, Paša-Tolić L, Robinson CV, ... ... Kelleher NL, et al. A five-level classification system for proteoform identifications. Nature Methods. PMID 31451767 DOI: 10.1038/S41592-019-0573-X  0.718
2019 Camarillo JM, Swaminathan S, Abshiru NA, Sikora JW, Thomas PM, Kelleher NL. Coupling Fluorescence-Activated Cell Sorting and Targeted Analysis of Histone Modification Profiles in Primary Human Leukocytes. Journal of the American Society For Mass Spectrometry. PMID 31286445 DOI: 10.1007/S13361-019-02255-X  0.517
2019 Moschitto MJ, Doubleday PF, Catlin DS, Kelleher NL, Liu D, Silverman RB. Mechanism of Inactivation of Ornithine Aminotransferase by (1 S,3 S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylic Acid. Journal of the American Chemical Society. PMID 31251613 DOI: 10.1021/Jacs.9B03254  0.333
2019 Donnelly DP, Rawlins CM, DeHart CJ, Fornelli L, Schachner LF, Lin Z, Lippens JL, Aluri KC, Sarin R, Chen B, Lantz C, Jung W, Johnson KR, Koller A, Wolff JJ, ... ... Kelleher NL, et al. Best practices and benchmarks for intact protein analysis for top-down mass spectrometry. Nature Methods. 16: 587-594. PMID 31249407 DOI: 10.1038/S41592-019-0457-0  0.692
2019 Huang X, LeDuc RD, Fornelli L, Schunter AJ, Bennett RL, Kelleher NL, Licht JD. Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding. The Journal of Biological Chemistry. PMID 31248990 DOI: 10.1074/Jbc.Ra118.006159  0.316
2019 Ro SY, Schachner LF, Koo CW, Purohit R, Remis JP, Kenney GE, Liauw BW, Thomas PM, Patrie SM, Kelleher NL, Rosenzweig AC. Native top-down mass spectrometry provides insights into the copper centers of membrane-bound methane monooxygenase. Nature Communications. 10: 2675. PMID 31209220 DOI: 10.1038/S41467-019-10590-6  0.731
2019 Schaffer LV, Millikin RJ, Miller RM, Anderson LC, Fellers RT, Ge Y, Kelleher NL, LeDuc RD, Liu X, Payne SH, Sun L, Thomas PM, Tucholski T, Wang Z, Wu S, et al. Identification and Quantification of Proteoforms by Mass Spectrometry. Proteomics. e1800361. PMID 31050378 DOI: 10.1002/Pmic.201800361  0.686
2019 Schachner LF, Ives AN, McGee JP, Melani RD, Kafader JO, Compton PD, Patrie SM, Kelleher NL. Standard Proteoforms and Their Complexes for Native Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 30963455 DOI: 10.1007/S13361-019-02191-W  0.734
2019 LeDuc RD, Fellers RT, Early BP, Greer JB, Shams DP, Thomas P, Kelleher NL. Accurate Estimation of Context-Dependent False Discovery Rates in Top-Down Proteomics. Molecular & Cellular Proteomics : McP. PMID 30647073 DOI: 10.1074/Mcp.Ra118.000993  0.537
2019 Kafader JO, Melani RD, Senko MW, Makarov AA, Kelleher NL, Compton PD. Measurement of Individual Ions Sharply Increases the Resolution of Orbitrap Mass Spectra of Proteins. Analytical Chemistry. PMID 30609364 DOI: 10.1021/Acs.Analchem.8B04519  0.389
2019 Lu D, Holton K, Hafner A, DeHart C, Sikora J, Zhou H, Jambhekar A, Kelleher N, Gunawardena J, Lahav G. Abstract LB-101: Combined p53 dynamics and post-translational modifications determine subsequent protein expression and cell fate Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-Lb-101  0.326
2019 Schaffer LV, Millikin RJ, Miller RM, Anderson LC, Fellers RT, Ge Y, Kelleher NL, LeDuc RD, Liu X, Payne SH, Sun L, Thomas PM, Tucholski T, Wang Z, Wu S, et al. Back Cover: Identification and Quantification of Proteoforms by Mass Spectrometry Proteomics. 19: 1970085. DOI: 10.1002/Pmic.201970085  0.663
2019 Liu Y, Fiorito J, Gonzale Y, Zuccarello E, Calcagno E, Camarillo J, Thomas P, Kelleher N, Deng S, Landry D, O'Connor O, Wolfe A, Moyer B, Arancio O, Amengual J. FIRST-IN-CLASS HAT ACTIVATOR HIGHLY SYNERGISTIC WITH PAN-HDAC INHIBITOR ROMIDEPSIN LEADING TO PROFOUND HISTONE ACETYLATION CYTOTOXICITY Hematological Oncology. 37: 125-126. DOI: 10.1002/Hon.85_2629  0.456
2018 Toby TK, Fornelli L, Srzentić K, DeHart CJ, Levitsky J, Friedewald J, Kelleher NL. A comprehensive pipeline for translational top-down proteomics from a single blood draw. Nature Protocols. PMID 30518910 DOI: 10.1038/S41596-018-0085-7  0.443
2018 Fisher OS, Kenney GE, Ross MO, Ro SY, Lemma BE, Batelu S, Thomas PM, Sosnowski VC, DeHart CJ, Kelleher NL, Stemmler TL, Hoffman BM, Rosenzweig AC. Characterization of a long overlooked copper protein from methane- and ammonia-oxidizing bacteria. Nature Communications. 9: 4276. PMID 30323281 DOI: 10.1038/s41467-018-06681-5  0.5
2018 Jin Q, Martinez CA, Arcipowski KM, Zhu Y, Gutiérrez-Díaz BT, Wang KK, Johnson MR, Volk A, Wang F, Wu J, Grove C, Wang H, Sokirniy I, Thomas PM, Goo YA, ... ... Kelleher NL, et al. USP7 cooperates with NOTCH1 to drive the oncogenic transcriptional program in T cell leukemia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30224337 DOI: 10.1158/1078-0432.Ccr-18-1740  0.442
2018 Gruppuso PA, Boylan JM, Zabala V, Neretti N, Abshiru NA, Sikora JW, Doud EH, Camarillo JM, Thomas PM, Kelleher NL, Sanders JA. Stability of histone post-translational modifications in samples derived from liver tissue and primary hepatic cells. Plos One. 13: e0203351. PMID 30192817 DOI: 10.1371/Journal.Pone.0203351  0.492
2018 Compton PD, Kelleher NL, Gunawardena J. Estimating the distribution of protein post-translational modification states by mass-spectrometry. Journal of Proteome Research. PMID 29945451 DOI: 10.1021/Acs.Jproteome.8B00150  0.429
2018 Riley NM, Sikora JW, Seckler HS, Greer JB, Fellers RT, LeDuc RD, Westphall MS, Thomas PM, Kelleher NL, Coon JJ. The Value of Activated Ion Electron Transfer Dissociation for High-Throughput Top-Down Characterization of Intact Proteins. Analytical Chemistry. PMID 29924586 DOI: 10.1021/Acs.Analchem.8B01638  0.6
2018 Mullowney MW, McClure RA, Robey MT, Kelleher NL, Thomson RJ. Natural products from thioester reductase containing biosynthetic pathways. Natural Product Reports. PMID 29916519 DOI: 10.1039/C8Np00013A  0.801
2018 Fornelli L, Srzentić K, Huguet R, Mullen C, Sharma S, Zabrouskov V, Fellers RT, Durbin KR, Compton PD, Kelleher NL. Accurate sequence analysis of a monoclonal antibody by top-down and middle-down Orbitrap mass spectrometry applying multiple ion activation techniques. Analytical Chemistry. PMID 29894161 DOI: 10.1021/Acs.Analchem.8B00984  0.404
2018 Alvares K, DeHart CJ, Thomas PM, Kelleher NL, Veis A. The unique biomineralization transcriptome and proteome of Lytechinus variegatus teeth. Connective Tissue Research. 59: 20-29. PMID 29745816 DOI: 10.1080/03008207.2017.1408605  0.487
2018 Park YJ, Kenney GE, Schachner LF, Kelleher NL, Rosenzweig AC. Repurposed HisC Aminotransferases Complete the Biosynthesis of Some Methanobactins. Biochemistry. PMID 29694778 DOI: 10.1021/Acs.Biochem.8B00296  0.356
2018 Zheng J, Chen L, Skinner OS, Ysselstein D, Remis J, Lansbury P, Skerlj R, Mrosek M, Heunisch U, Krapp S, Charrow J, Schwake M, Kelleher NL, Silverman RB, Krainc D. β-Glucocerebrosidase modulators promote dimerization of β-glucocerebrosidase and reveal an allosteric binding site. Journal of the American Chemical Society. PMID 29676907 DOI: 10.1021/Jacs.7B13003  0.7
2018 Robey MT, Ye R, Bok JW, Clevenger KD, Islam MN, Chen C, Gupta R, Swyers M, Wu E, Gao P, Thomas PM, Wu CC, Keller NP, Kelleher NL. Identification of the First Diketomorpholine Biosynthetic Pathway Using FAC-MS Technology. Acs Chemical Biology. PMID 29631395 DOI: 10.1021/Acschembio.8B00024  0.572
2018 Ntai I, Fornelli L, DeHart CJ, Hutton JE, Doubleday PF, LeDuc RD, van Nispen AJ, Fellers RT, Whiteley G, Boja ES, Rodriguez H, Kelleher NL. Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk. Proceedings of the National Academy of Sciences of the United States of America. PMID 29610327 DOI: 10.1073/Pnas.1716122115  0.679
2018 Smith LM, Kelleher NL. Proteoforms as the next proteomics currency. Science (New York, N.Y.). 359: 1106-1107. PMID 29590032 DOI: 10.1126/Science.Aat1884  0.385
2018 Miley GP, Rote JC, Silverman RB, Kelleher NL, Thomson RJ. Total Synthesis of Tambromycin Enabled by Indole C-H Functionalization. Organic Letters. PMID 29584440 DOI: 10.1021/Acs.Orglett.8B00700  0.525
2018 Martin RW, Des Soye BJ, Kwon YC, Kay J, Davis RG, Thomas PM, Majewska NI, Chen CX, Marcum RD, Weiss MG, Stoddart AE, Amiram M, Ranji Charna AK, Patel JR, Isaacs FJ, ... Kelleher NL, et al. Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids. Nature Communications. 9: 1203. PMID 29572528 DOI: 10.1038/S41467-018-03469-5  0.554
2018 Kenney GE, Dassama LMK, Pandelia ME, Gizzi AS, Martinie RJ, Gao P, DeHart CJ, Schachner LF, Skinner OS, Ro SY, Zhu X, Sadek M, Thomas PM, Almo SC, Bollinger JM, ... ... Kelleher NL, et al. The biosynthesis of methanobactin. Science (New York, N.Y.). 359: 1411-1416. PMID 29567715 DOI: 10.1126/Science.Aap9437  0.788
2018 Clevenger KD, Ye R, Bok JW, Thomas PM, Islam MN, Miley GP, Robey M, Chen C, Yang K, Swyers M, Wu E, Gao P, Wu C, Keller NP, Kelleher NL. Interrogation of Benzomalvin Biosynthesis using FAC-MS: Discovery of a Benzodiazepine Synthase Activity. Biochemistry. PMID 29533658 DOI: 10.1021/Acs.Biochem.8B00076  0.579
2018 Parkinson EI, Tryon JH, Goering AW, Ju KS, McClure RA, Kemball JD, Zhukovsky S, Labeda DP, Thomson RJ, Kelleher NL, Metcalf WW. Discovery of the tyrobetaine natural products and their biosynthetic gene cluster via metabologenomics. Acs Chemical Biology. PMID 29510029 DOI: 10.1021/Acschembio.7B01089  0.52
2018 Davis RG, Park HM, Kim K, Greer JB, Fellers RT, LeDuc RD, Romanova EV, Rubakhin SS, Zombeck JA, Wu C, Yau PM, Gao P, van Nispen AJ, Patrie SM, Thomas PM, ... ... Kelleher NL, et al. Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms Between Mouse Strains. Analytical Chemistry. PMID 29481055 DOI: 10.1021/Acs.Analchem.7B04108  0.748
2018 Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, ... ... Kelleher NL, et al. How many human proteoforms are there? Nature Chemical Biology. 14: 206-214. PMID 29443976 DOI: 10.1038/Nchembio.2576  0.812
2018 LeDuc RD, Schwämmle V, Shortreed MR, Cesnik AJ, Solntsev SK, Shaw JB, Martin MJ, Vizcaíno JA, Alpi E, Danis P, Kelleher NL, Smith LM, Ge Y, Agar JN, Chamot-Rooke J, et al. ProForma: a Standard Proteoform Notation. Journal of Proteome Research. PMID 29397739 DOI: 10.1021/Acs.Jproteome.7B00851  0.624
2017 Skinner OS, Haverland NA, Fornelli L, Melani RD, Do Vale LHF, Seckler HS, Doubleday PF, Schachner LF, Srzentić K, Kelleher NL, Compton PD. Top-down characterization of endogenous protein complexes with native proteomics. Nature Chemical Biology. PMID 29131144 DOI: 10.1038/Nchembio.2515  0.755
2017 Morgan MAJ, Rickels RA, Collings CK, He X, Cao K, Herz HM, Cozzolino KA, Abshiru NA, Marshall SA, Rendleman EJ, Sze CC, Piunti A, Kelleher NL, Savas JN, Shilatifard A. A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation. Genes & Development. 31: 2003-2014. PMID 29089422 DOI: 10.1101/Gad.305201.117  0.3
2017 Rickels R, Herz HM, Sze CC, Cao K, Morgan MA, Collings CK, Gause M, Takahashi YH, Wang L, Rendleman EJ, Marshall SA, Krueger A, Bartom ET, Piunti A, Smith ER, ... ... Kelleher NL, et al. Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability. Nature Genetics. PMID 28967912 DOI: 10.1038/Ng.3965  0.327
2017 Skinner OS, McAnally MO, Van Duyne RP, Schatz GC, Breuker K, Compton PD, Kelleher NL. Native Electron Capture Dissociation Maps to Iron-Binding Channels in Horse Spleen Ferritin. Analytical Chemistry. PMID 28938074 DOI: 10.1021/Acs.Analchem.7B01581  0.696
2017 Ichikawa Y, Connelly CF, Appleboim A, Miller TC, Jacobi H, Abshiru NA, Chou HJ, Chen Y, Sharma U, Zheng Y, Thomas PM, Chen HV, Bajaj V, Müeller CW, Kelleher NL, et al. A synthetic biology approach to probing nucleosome symmetry. Elife. 6. PMID 28895528 DOI: 10.7554/Elife.28836  0.516
2017 Wildburger NC, Esparza TJ, LeDuc RD, Fellers RT, Thomas PM, Cairns NJ, Kelleher NL, Bateman RJ, Brody DL. Diversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain. Scientific Reports. 7: 9520. PMID 28842697 DOI: 10.1038/S41598-017-10422-X  0.46
2017 Haverland NA, Waas M, Ntai I, Keppel T, Gundry RL, Kelleher NL. Cell Surface Proteomics of N-Linked Glycoproteins for Typing of Human Lymphocytes. Proteomics. PMID 28834292 DOI: 10.1002/Pmic.201700156  0.669
2017 Zha L, Jiang Y, Henke MT, Wilson MR, Wang JX, Kelleher NL, Balskus EP. Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring. Nature Chemical Biology. PMID 28805802 DOI: 10.1038/Nchembio.2448  0.785
2017 Clevenger KD, Bok JW, Ye R, Miley GP, Verdan MH, Velk T, Chen C, Yang K, Robey MT, Gao P, Lamprecht M, Thomas PM, Islam MN, Palmer JM, Wu CC, ... ... Kelleher NL, et al. A scalable platform to identify fungal secondary metabolites and their gene clusters. Nature Chemical Biology. PMID 28604695 DOI: 10.1038/Nchembio.2408  0.53
2017 Toby TK, Abecassis M, Kim K, Thomas PM, Fellers RT, LeDuc RD, Kelleher NL, Demetris J, Levitsky J. Proteoforms in Peripheral Blood Mononuclear Cells as Novel Rejection Biomarkers in Liver Transplant Recipients. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 28510335 DOI: 10.1111/Ajt.14359  0.514
2017 Cleland TP, DeHart CJ, Fellers RT, VanNispen AJ, Greer JB, LeDuc RD, Parker WR, Thomas PM, Kelleher NL, Brodbelt JS. High-throughput analysis of intact human proteins using UVPD and HCD on an Orbitrap mass spectrometer. Journal of Proteome Research. PMID 28412815 DOI: 10.1021/Acs.Jproteome.7B00043  0.61
2017 Greer SM, Holden DD, Fellers R, Kelleher NL, Brodbelt JS. Modulation of Protein Fragmentation Through Carbamylation of Primary Amines. Journal of the American Society For Mass Spectrometry. PMID 28374316 DOI: 10.1007/S13361-017-1648-5  0.427
2017 Haverland NA, Skinner OS, Fellers RT, Tariq AA, Early BP, LeDuc RD, Fornelli L, Compton PD, Kelleher NL. Defining Gas-Phase Fragmentation Propensities of Intact Proteins During Native Top-Down Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 28374312 DOI: 10.1007/S13361-017-1635-X  0.753
2017 Piunti A, Hashizume R, Morgan MA, Bartom ET, Horbinski CM, Marshall SA, Rendleman EJ, Ma Q, Takahashi YH, Woodfin AR, Misharin AV, Abshiru NA, Lulla RR, Saratsis AM, Kelleher NL, et al. Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas. Nature Medicine. PMID 28263307 DOI: 10.1038/Nm.4296  0.338
2017 Mandacaru SC, Vale LH, Vahidi S, Xiao Y, Skinner OS, Ricart CA, Kelleher NL, Sousa MV, Konermann L. Characterizing the Structure and Oligomerization of Major Royal Jelly Protein 1 (MRJP1) by Mass Spectrometry and Complementary Biophysical Tools. Biochemistry. PMID 28252287 DOI: 10.1021/Acs.Biochem.7B00020  0.738
2017 Fornelli L, Toby TK, Schachner LF, Doubleday PF, Srzentić K, DeHart CJ, Kelleher NL. Top-down proteomics: Where we are, where we are going? Journal of Proteomics. PMID 28188863 DOI: 10.1016/J.Jprot.2017.02.002  0.387
2017 Clevenger KD, Mascarenhas R, Catlin D, Wu R, Kelleher NL, Drake EJ, Gulick AM, Liu D, Fast W. Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ. Acs Chemical Biology. PMID 28186406 DOI: 10.1021/Acschembio.7B00031  0.317
2017 Fornelli L, Durbin KR, Fellers RT, Early BP, Greer JB, LeDuc RD, Compton PD, Kelleher NL. Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer. Journal of Proteome Research. 16: 609-618. PMID 28152595 DOI: 10.1021/Acs.Jproteome.6B00698  0.435
2017 DeHart CJ, Fellers RT, Fornelli L, Kelleher NL, Thomas PM. Bioinformatics Analysis of Top-Down Mass Spectrometry Data with ProSight Lite. Methods in Molecular Biology (Clifton, N.J.). 1558: 381-394. PMID 28150248 DOI: 10.1007/978-1-4939-6783-4_18  0.616
2017 Schroeter ER, DeHart CJ, Cleland TP, Zheng W, Thomas PM, Kelleher NL, Bern M, Schweitzer MH. Expansion for the Brachylophosaurus canadensis Collagen I Sequence and Additional Evidence of the Preservation of Cretaceous Protein. Journal of Proteome Research. PMID 28111950 DOI: 10.1021/Acs.Jproteome.6B00873  0.539
2017 Ichikawa Y, Connelly CF, Appleboim A, Miller TC, Jacobi H, Abshiru NA, Chou H, Chen Y, Sharma U, Zheng Y, Thomas PM, Chen HV, Bajaj V, Müller CW, Kelleher NL, et al. Author response: A synthetic biology approach to probing nucleosome symmetry Elife. DOI: 10.7554/Elife.28836.019  0.443
2017 Dupere-Richer D, Ezponda T, Will C, Small EC, Varghese N, Tej P, Huang X, Yupeng Z, Tonon G, Kelleher N, Keats J, Licht JD. Abstract 12: KMD6A/UTX loss enhances the malignant phenotype of multiple myeloma and sensitizes cells to EZH2 inhibition Epigenetics. 23: 12-12. DOI: 10.1158/1557-3265.Hemmal17-12  0.315
2017 Haverland NA, Waas M, Ntai I, Keppel T, Gundry RL, Kelleher NL. Front Cover: Cell Surface Proteomics of N-Linked Glycoproteins for Typing of Human Lymphocytes Proteomics. 17: 1770141. DOI: 10.1002/Pmic.201770141  0.656
2016 Zhou Y, Zhang X, Fornelli L, Compton PD, Kelleher N, Wirth MJ. Chromatographic efficiency and selectivity in top-down proteomics of histones. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1044: 47-53. PMID 28076774 DOI: 10.1016/J.Jchromb.2016.12.027  0.331
2016 Gan R, Perez JG, Carlson ED, Ntai I, Isaacs FJ, Kelleher NL, Jewett MC. Translation system engineering in Escherichia coli enhances non-canonical amino acid incorporation into proteins. Biotechnology and Bioengineering. PMID 27987323 DOI: 10.1002/Bit.26239  0.723
2016 Clevenger KD, Bok JW, Ye R, Miley GP, Velk T, Chen C, Yang K, Gao P, Lamprecht M, Thomas PM, Islam MN, Wu CC, Keller NP, Kelleher NL. Large scale discovery and deorphanization of natural products using fungal artificial chromosomes and untargeted metabolomics (FAC-MS). Planta Medica. 81: S1-S381. PMID 27976333 DOI: 10.1055/S-0036-1596148  0.51
2016 Anderson LC, DeHart CJ, Kaiser NK, Fellers RT, Smith DF, Greer JB, LeDuc RD, Blakney GT, Thomas PM, Kelleher NL, Hendrickson CL. Identification and Characterization of Human Proteoforms by Top-Down LC-21 Tesla FT-ICR Mass Spectrometry. Journal of Proteome Research. PMID 27936753 DOI: 10.1021/Acs.Jproteome.6B00696  0.596
2016 Skinner OS, Schachner LF, Kelleher NL. The Search Engine for Multi-Proteoform Complexes: An Online Tool for the Identification and Stoichiometry Determination of Protein Complexes. Current Protocols in Bioinformatics. 56: 13.30.1-13.30.11. PMID 27930806 DOI: 10.1002/Cpbi.16  0.743
2016 Schroeter ER, DeHart CJ, Schweitzer MH, Thomas PM, Kelleher NL. Bone protein "extractomics": comparing the efficiency of bone protein extractions of Gallus gallus in tandem mass spectrometry, with an eye towards paleoproteomics. Peerj. 4: e2603. PMID 27812413 DOI: 10.7717/Peerj.2603  0.566
2016 McClure RA, Goering AW, Ju KS, Baccile JA, Schroeder FC, Metcalf WW, Thomson RJ, Kelleher NL. Elucidating the rimosamide-detoxin natural product families and their biosynthesis using metabolite/gene cluster correlations. Acs Chemical Biology. PMID 27809474 DOI: 10.1021/Acschembio.6B00779  0.518
2016 Savaryn JP, Toby TK, Kelleher NL. A researcher's guide to mass spectrometry-based proteomics. Proteomics. PMID 27553853 DOI: 10.1002/Pmic.201600113  0.429
2016 Kenney GE, Goering AW, Ross MO, DeHart CJ, Thomas PM, Hoffman BM, Kelleher NL, Rosenzweig AC. Characterization of methanobactin from Methylosinus sp. LW4. Journal of the American Chemical Society. PMID 27527063 DOI: 10.1021/Jacs.6B06821  0.548
2016 Goering AW, Li J, McClure RA, Thomson RJ, Jewett MC, Kelleher NL. In vitro Reconstruction of Nonribosomal Peptide Biosynthesis Directly from DNA Using Cell-Free Protein Synthesis. Acs Synthetic Biology. PMID 27478992 DOI: 10.1021/Acssynbio.6B00160  0.609
2016 Henke MT, Kelleher NL. Modern mass spectrometry for synthetic biology and structure-based discovery of natural products. Natural Product Reports. PMID 27376415 DOI: 10.1039/C6Np00024J  0.819
2016 Zheng Y, Huang X, Kelleher NL. Epiproteomics: quantitative analysis of histone marks and codes by mass spectrometry. Current Opinion in Chemical Biology. 33: 142-150. PMID 27371874 DOI: 10.1016/J.Cbpa.2016.06.007  0.385
2016 Henke MT, Soukup AA, Goering AW, McClure RA, Thomson RJ, Keller NP, Kelleher NL. New aspercryptins, lipopeptide natural products, revealed by HDAC inhibition in Aspergillus nidulans. Acs Chemical Biology. PMID 27310134 DOI: 10.1021/Acschembio.6B00398  0.798
2016 Toby TK, Fornelli L, Kelleher NL. Progress in Top-Down Proteomics and the Analysis of Proteoforms. Annual Review of Analytical Chemistry (Palo Alto, Calif.). 9: 499-519. PMID 27306313 DOI: 10.1146/Annurev-Anchem-071015-041550  0.464
2016 LaFave LM, Béguelin W, Koche R, Teater M, Spitzer B, Chramiec A, Papalexi E, Keller MD, Hricik T, Konstantinoff K, Micol JB, Durham B, Knutson SK, Campbell JE, Blum G, ... ... Kelleher NL, et al. Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status". Nature Medicine. 22: 578-579. PMID 27270773 DOI: 10.1038/Nm.4094  0.419
2016 Melani RD, Skinner OS, Fornelli L, Domont GB, Compton PD, Kelleher NL. Mapping proteoforms and protein complexes from king cobra venom using both denaturing and native top-down proteomics. Molecular & Cellular Proteomics : McP. PMID 27178327 DOI: 10.1074/Mcp.M115.056523  0.768
2016 Goering AW, McClure RA, Doroghazi JR, Albright JC, Haverland NA, Zhang Y, Ju KS, Thomson RJ, Metcalf WW, Kelleher NL. Metabologenomics: Correlation of Microbial Gene Clusters with Metabolites Drives Discovery of a Nonribosomal Peptide with an Unusual Amino Acid Monomer. Acs Central Science. 2: 99-108. PMID 27163034 DOI: 10.1021/Acscentsci.5B00331  0.565
2016 Savaryn JP, Toby TK, Catherman AD, Fellers RT, LeDuc RD, Thomas PM, Friedewald JJ, Salomon DR, Abecassis MM, Kelleher NL. Comparative top down proteomics of peripheral blood mononuclear cells from kidney transplant recipients with normal kidney biopsies or acute rejection. Proteomics. PMID 27120713 DOI: 10.1002/Pmic.201600008  0.799
2016 Melani RD, Seckler HS, Skinner OS, Do Vale LH, Catherman AD, Havugimana PC, Valle de Sousa M, Domont GB, Kelleher NL, Compton PD. CN-GELFrEE - Clear Native Gel-eluted Liquid Fraction Entrapment Electrophoresis. Journal of Visualized Experiments : Jove. PMID 26967310 DOI: 10.3791/53597  0.811
2016 Ong TH, Romanova EV, Roberts-Galbraith RH, Yang N, Zimmerman TA, Collins JJ, Lee JE, Kelleher NL, Newmark PA, Sweedler JV. Mass Spectrometry Imaging and Identification of Peptides Associated with Cephalic Ganglia Regeneration in Schmidtea mediterranea. The Journal of Biological Chemistry. 291: 8109-20. PMID 26884331 DOI: 10.1074/Jbc.M115.709196  0.747
2016 Ntai I, Toby TK, LeDuc RD, Kelleher NL. A Method for Label-Free, Differential Top-Down Proteomics. Methods in Molecular Biology (Clifton, N.J.). 1410: 121-33. PMID 26867742 DOI: 10.1007/978-1-4939-3524-6_8  0.74
2016 Chen Y, McClure RA, Kelleher NL. Screening for Expressed Nonribosomal Peptide Synthetases and Polyketide Synthases Using LC-MS/MS-Based Proteomics. Methods in Molecular Biology (Clifton, N.J.). 1401: 135-47. PMID 26831706 DOI: 10.1007/978-1-4939-3375-4_9  0.681
2016 Durbin KR, Fornelli L, Fellers RT, Doubleday PF, Narita M, Kelleher NL. Quantitation and Identification of Thousands of Human Proteoforms Below 30 kDa. Journal of Proteome Research. PMID 26795204 DOI: 10.1021/Acs.Jproteome.5B00997  0.427
2016 Skinner OS, Havugimana PC, Haverland NA, Fornelli L, Early BP, Greer JB, Fellers RT, Durbin KR, Do Vale LH, Melani RD, Seckler HS, Nelp MT, Belov ME, Horning SR, Makarov AA, ... ... Kelleher NL, et al. An informatic framework for decoding protein complexes by top-down mass spectrometry. Nature Methods. PMID 26780093 DOI: 10.1038/Nmeth.3731  0.756
2016 Greer J, Fellers R, LeDuc R, Nispen AJV, Early B, Thomas P, Kelleher N. National resource for translational and developmental proteomics Galaxy portal F1000research. 5. DOI: 10.7490/F1000Research.1112748.1  0.469
2016 Ntziachristos P, Arcipowski K, Martinez CA, Zhu Y, Volk AG, Kumar S, Thomas PM, Van Vlierberghe P, Hijiya N, Marshall S, Wang J, Wu J, Kelleher NL, Crispino J. Therapeutic Targeting of the Histone Ubiquitination-Methylation Axis in T Cell Leukemia Blood. 128: 1532-1532. DOI: 10.1182/Blood.V128.22.1532.1532  0.503
2015 Kim K, Compton PD, Toby TK, Thomas PM, Wilkins JT, Mutharasan RK, Kelleher NL. Reducing protein oxidation in low-flow electrospray enables deeper investigation of proteoforms by top down proteomics. Eupa Open Proteomics. 8: 40-47. PMID 26753126 DOI: 10.1016/J.Euprot.2015.05.005  0.584
2015 Compton PD, Fornelli L, Kelleher NL, Skinner OS. Probing Asymmetric Charge Partitioning of Protein Oligomers during Tandem Mass Spectrometry. International Journal of Mass Spectrometry. 390: 132-136. PMID 26692813 DOI: 10.1016/J.Ijms.2015.08.021  0.713
2015 Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS. A systems proteomics view of the endogenous human claudin protein family. Journal of Proteome Research. PMID 26680015 DOI: 10.1021/Acs.Jproteome.5B00769  0.361
2015 Cleland TP, Schroeter ER, Zamdborg L, Zheng W, Lee JE, Tran JC, Bern M, Duncan MB, Lebleu VS, Ahlf DR, Thomas PM, Kalluri R, Kelleher NL, Schweitzer MH. Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis. Journal of Proteome Research. PMID 26595531 DOI: 10.1021/Acs.Jproteome.5B00675  0.553
2015 Amiram M, Haimovich AD, Fan C, Wang YS, Aerni HR, Ntai I, Moonan DW, Ma NJ, Rovner AJ, Hong SH, Kelleher NL, Goodman AL, Jewett MC, Söll D, Rinehart J, et al. Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids. Nature Biotechnology. PMID 26571098 DOI: 10.1038/Nbt.3372  0.718
2015 Ntai I, LeDuc RD, Fellers RT, Erdmann-Gilmore P, Davies SR, Rumsey J, Early BP, Thomas PM, Li S, Compton PD, Ellis MJ, Ruggles KV, Fenyo D, Boja ES, Rodriguez H, ... ... Kelleher NL, et al. Integrated Bottom-up and Top-down Proteomics of Patient-derived Breast Tumor Xenografts. Molecular & Cellular Proteomics : McP. PMID 26503891 DOI: 10.1074/Mcp.M114.047480  0.772
2015 Rodrigues Lorenzatto K, Kim K, Ntai I, Prado Paludo G, Camargo de Lima J, Thomas PM, Kelleher NL, Ferreira HB. Top down proteomics reveals mature proteoforms expressed in subcellular fractions of the Echinococcus granulosus pre-adult stage. Journal of Proteome Research. PMID 26465659 DOI: 10.1021/Acs.Jproteome.5B00642  0.784
2015 LaFave LM, Béguelin W, Koche R, Teater M, Spitzer B, Chramiec A, Papalexi E, Keller MD, Hricik T, Konstantinoff K, Micol JB, Durham B, Knutson SK, Campbell JE, Blum G, ... ... Kelleher NL, et al. Loss of BAP1 function leads to EZH2-dependent transformation. Nature Medicine. PMID 26437366 DOI: 10.1038/Nm.3947  0.484
2015 Ye H, Wang J, Zhang Z, Jia C, Schmerberg CM, Catherman AD, Thomas PM, Kelleher NL, Li L. Defining the Neuropeptidome of the Spiny Lobster Panulirus interruptus Brain Using a Multi-Dimensional Mass Spectrometry-Based Platform. Journal of Proteome Research. PMID 26390183 DOI: 10.1021/Acs.Jproteome.5B00627  0.799
2015 Zheng Y, Fornelli L, Compton PD, Sharma S, Canterbury J, Mullen C, Zabrouskov V, Fellers RT, Thomas PM, Licht JD, Senko MW, Kelleher NL. Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression. Molecular & Cellular Proteomics : McP. PMID 26272979 DOI: 10.1074/Mcp.M115.053819  0.524
2015 Skinner OS, Kelleher NL. Illuminating the dark matter of shotgun proteomics. Nature Biotechnology. 33: 717-8. PMID 26154010 DOI: 10.1038/Nbt.3287  0.72
2015 Lee H, Le HV, Wu R, Doud E, Sanishvili R, Kellie JF, Compton PD, Pachaiyappan B, Liu D, Kelleher NL, Silverman RB. Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid. Acs Chemical Biology. PMID 26110556 DOI: 10.1021/Acschembio.5B00212  0.685
2015 Savaryn JP, Skinner OS, Fornelli L, Fellers RT, Compton PD, Terhune SS, Abecassis MM, Kelleher NL. Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry. Journal of Proteomics. PMID 25952688 DOI: 10.1016/J.Jprot.2015.04.025  0.746
2015 Bok JW, Ye R, Clevenger KD, Mead D, Wagner M, Krerowicz A, Albright JC, Goering AW, Thomas PM, Kelleher NL, Keller NP, Wu CC. Fungal artificial chromosomes for mining of the fungal secondary metabolome. Bmc Genomics. 16: 343. PMID 25925221 DOI: 10.1186/S12864-015-1561-X  0.515
2015 Tang W, Li H, Doud EH, Chen Y, Choing S, Plaza C, Kelleher NL, Poulos TL, Silverman RB. Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(methylthio)acetimidamido)pentanoic Acid. Journal of the American Chemical Society. 137: 5980-9. PMID 25874809 DOI: 10.1021/Jacs.5B01202  0.579
2015 Kim KH, Compton PD, Tran JC, Kelleher NL. Online matrix removal platform for coupling gel-based separations to whole protein electrospray ionization mass spectrometry. Journal of Proteome Research. 14: 2199-206. PMID 25836738 DOI: 10.1021/Pr501331Q  0.45
2015 Fellers RT, Greer JB, Early BP, Yu X, LeDuc RD, Kelleher NL, Thomas PM. ProSight Lite: graphical software to analyze top-down mass spectrometry data. Proteomics. 15: 1235-8. PMID 25828799 DOI: 10.1002/Pmic.201400313  0.569
2015 Albright JC, Henke MT, Soukup AA, McClure RA, Thomson RJ, Keller NP, Kelleher NL. Large-Scale Metabolomics Reveals a Complex Response of Aspergillus nidulans to Epigenetic Perturbation. Acs Chemical Biology. 10: 1535-41. PMID 25815712 DOI: 10.1021/Acschembio.5B00025  0.793
2015 Hong SH, Kwon YC, Martin RW, Des Soye BJ, de Paz AM, Swonger KN, Ntai I, Kelleher NL, Jewett MC. Improving cell-free protein synthesis through genome engineering of Escherichia coli lacking release factor 1. Chembiochem : a European Journal of Chemical Biology. 16: 844-53. PMID 25737329 DOI: 10.1002/Cbic.201402708  0.702
2015 Durbin KR, Skinner OS, Fellers RT, Kelleher NL. Analyzing internal fragmentation of electrosprayed ubiquitin ions during beam-type collisional dissociation. Journal of the American Society For Mass Spectrometry. 26: 782-7. PMID 25716753 DOI: 10.1007/S13361-015-1078-1  0.714
2015 Skinner OS, Do Vale LH, Catherman AD, Havugimana PC, de Sousa MV, Compton PD, Kelleher NL. Native GELFrEE: a new separation technique for biomolecular assemblies. Analytical Chemistry. 87: 3032-8. PMID 25664979 DOI: 10.1021/Ac504678D  0.822
2015 LaFave LM, Béguelin W, Koche R, Teater M, Papalexi E, Spitzer B, Knutson S, Campbell J, Keilhack H, Thomas PM, Kelleher NL, Abdel-Wahab O, Melnick AM, Armstrong SA, Levine RL. BAP1 Loss Results in EZH2-Dependent Transformation in Myelodysplastic Syndromes Blood. 126: 713-713. DOI: 10.1182/Blood.V126.23.713.713  0.49
2015 Oyer J, Will C, Huang X, Ezponda T, Popovic R, Zheng Y, Kelleher NL, Licht JD. Allele-Specific Crispr Targeting Reveals Epigenetic and Phenotypic Effects of a MMSET Gain of Function Mutation Found in Relapsed Acute Lymphoblastic Leukemia Blood. 126: 437-437. DOI: 10.1182/Blood.V126.23.437.437  0.306
2015 Ezponda T, Popovic R, Zheng Y, Nabet B, Will C, Small E, Occhionorelli M, Tonon G, Keats J, Kelleher N, Licht JD. Abstract B32: Loss of the histone demethylase UTX alters the gene expression prolife and contributes to the malignant phenotype of multiple myeloma cells. Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Hemmal14-B32  0.306
2015 Kelleher N. Abstract SY30-04: Can protein discovery with complete molecular specificity increase return on investment for cancer biomarkers Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Sy30-04  0.313
2015 Kim K, Compton PD, Toby TK, Thomas PM, Wilkins JT, Mutharasan RK, Kelleher NL. Reducing protein oxidation in low-flow electrospray enables deeper investigation of proteoforms by top down proteomics Eupa Open Proteomics. DOI: 10.1016/j.euprot.2015.05.005  0.443
2015 Hong SH, Kwon Y, Martin RW, Des Soye BJ, de Paz AM, Swonger KN, Ntai I, Kelleher NL, Jewett MC. Inside Cover: Improving Cell-Free Protein Synthesis through Genome Engineering ofEscherichia coliLacking Release Factor 1 (ChemBioChem 5/2015) Chembiochem. 16: 698-698. DOI: 10.1002/Cbic.201590010  0.674
2014 Fellers RT, Greer JB, Early BP, Yu X, LeDuc RD, Kelleher NL, Thomas PM. ProSight Lite: Graphical software to analyze top-down mass spectrometry data. Proteomics. PMID 25504941 DOI: 10.1002/pmic.201400313  0.459
2014 Kelleher NL, Thomas PM, Ntai I, Compton PD, LeDuc RD. Deep and quantitative top-down proteomics in clinical and translational research. Expert Review of Proteomics. 11: 649-51. PMID 25347991 DOI: 10.1586/14789450.2014.976559  0.762
2014 Doroghazi JR, Albright JC, Goering AW, Ju KS, Haines RR, Tchalukov KA, Labeda DP, Kelleher NL, Metcalf WW. A roadmap for natural product discovery based on large-scale genomics and metabolomics. Nature Chemical Biology. 10: 963-8. PMID 25262415 DOI: 10.1038/Nchembio.1659  0.321
2014 Popovic R, Martinez-Garcia E, Giannopoulou EG, Zhang Q, Zhang Q, Ezponda T, Shah MY, Zheng Y, Will CM, Small EC, Hua Y, Bulic M, Jiang Y, Carrara M, Calogero RA, ... ... Kelleher NL, et al. Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation. Plos Genetics. 10: e1004566. PMID 25188243 DOI: 10.1371/Journal.Pgen.1004566  0.305
2014 LeDuc RD, Fellers RT, Early BP, Greer JB, Thomas PM, Kelleher NL. The C-score: a Bayesian framework to sharply improve proteoform scoring in high-throughput top down proteomics. Journal of Proteome Research. 13: 3231-40. PMID 24922115 DOI: 10.1021/Pr401277R  0.514
2014 Zheng Y, Tipton JD, Thomas PM, Kelleher NL, Sweet SM. Site-specific human histone H3 methylation stability: fast K4me3 turnover. Proteomics. 14: 2190-9. PMID 24826939 DOI: 10.1002/Pmic.201400060  0.487
2014 Ntai I, Kim K, Fellers RT, Skinner OS, Smith AD, Early BP, Savaryn JP, LeDuc RD, Thomas PM, Kelleher NL. Applying label-free quantitation to top down proteomics. Analytical Chemistry. 86: 4961-8. PMID 24807621 DOI: 10.1021/Ac500395K  0.819
2014 Ye H, Mandal R, Catherman A, Thomas PM, Kelleher NL, Ikonomidou C, Li L. Top-down proteomics with mass spectrometry imaging: a pilot study towards discovery of biomarkers for neurodevelopmental disorders. Plos One. 9: e92831. PMID 24710523 DOI: 10.1371/Journal.Pone.0092831  0.79
2014 Skinner OS, Catherman AD, Early BP, Thomas PM, Compton PD, Kelleher NL. Fragmentation of integral membrane proteins in the gas phase. Analytical Chemistry. 86: 4627-34. PMID 24689519 DOI: 10.1021/Ac500864W  0.772
2014 Dang X, Scotcher J, Wu S, Chu RK, Tolić N, Ntai I, Thomas PM, Fellers RT, Early BP, Zheng Y, Durbin KR, Leduc RD, Wolff JJ, Thompson CJ, Pan J, ... ... Kelleher NL, et al. The first pilot project of the consortium for top-down proteomics: a status report. Proteomics. 14: 1130-40. PMID 24644084 DOI: 10.1002/Pmic.201300438  0.799
2014 Li Y, Compton PD, Tran JC, Ntai I, Kelleher NL. Optimizing capillary electrophoresis for top-down proteomics of 30-80 kDa proteins. Proteomics. 14: 1158-64. PMID 24596178 DOI: 10.1002/Pmic.201300381  0.758
2014 Catherman AD, Skinner OS, Kelleher NL. Top Down proteomics: facts and perspectives. Biochemical and Biophysical Research Communications. 445: 683-93. PMID 24556311 DOI: 10.1016/J.Bbrc.2014.02.041  0.844
2014 Cannon JR, Cammarata MB, Robotham SA, Cotham VC, Shaw JB, Fellers RT, Early BP, Thomas PM, Kelleher NL, Brodbelt JS. Ultraviolet photodissociation for characterization of whole proteins on a chromatographic time scale. Analytical Chemistry. 86: 2185-92. PMID 24447299 DOI: 10.1021/Ac403859A  0.623
2014 Durbin KR, Fellers RT, Ntai I, Kelleher NL, Compton PD. Autopilot: an online data acquisition control system for the enhanced high-throughput characterization of intact proteins. Analytical Chemistry. 86: 1485-92. PMID 24400813 DOI: 10.1021/Ac402904H  0.752
2014 Hong SH, Ntai I, Haimovich AD, Kelleher NL, Isaacs FJ, Jewett MC. Cell-free protein synthesis from a release factor 1 deficient Escherichia coli activates efficient and multiple site-specific nonstandard amino acid incorporation. Acs Synthetic Biology. 3: 398-409. PMID 24328168 DOI: 10.1021/Sb400140T  0.716
2014 Southey BR, Lee JE, Zamdborg L, Atkins N, Mitchell JW, Li M, Gillette MU, Kelleher NL, Sweedler JV. Comparing label-free quantitative peptidomics approaches to characterize diurnal variation of peptides in the rat suprachiasmatic nucleus. Analytical Chemistry. 86: 443-52. PMID 24313826 DOI: 10.1021/Ac4023378  0.585
2014 Albright JC, Goering AW, Doroghazi JR, Metcalf WW, Kelleher NL. Strain-specific proteogenomics accelerates the discovery of natural products via their biosynthetic pathways. Journal of Industrial Microbiology & Biotechnology. 41: 451-9. PMID 24242000 DOI: 10.1007/S10295-013-1373-4  0.368
2013 Belov ME, Damoc E, Denisov E, Compton PD, Horning S, Makarov AA, Kelleher NL. From protein complexes to subunit backbone fragments: a multi-stage approach to native mass spectrometry. Analytical Chemistry. 85: 11163-73. PMID 24237199 DOI: 10.1021/Ac4029328  0.475
2013 Catherman AD, Durbin KR, Ahlf DR, Early BP, Fellers RT, Tran JC, Thomas PM, Kelleher NL. Large-scale top-down proteomics of the human proteome: membrane proteins, mitochondria, and senescence. Molecular & Cellular Proteomics : McP. 12: 3465-73. PMID 24023390 DOI: 10.1074/Mcp.M113.030114  0.819
2013 Ahlf DR, Thomas PM, Kelleher NL. Developing top down proteomics to maximize proteome and sequence coverage from cells and tissues. Current Opinion in Chemical Biology. 17: 787-94. PMID 23988518 DOI: 10.1016/J.Cbpa.2013.07.028  0.601
2013 Zheng Y, Thomas PM, Kelleher NL. Measurement of acetylation turnover at distinct lysines in human histones identifies long-lived acetylation sites. Nature Communications. 4: 2203. PMID 23892279 DOI: 10.1038/Ncomms3203  0.492
2013 Savaryn JP, Catherman AD, Thomas PM, Abecassis MM, Kelleher NL. The emergence of top-down proteomics in clinical research. Genome Medicine. 5: 53. PMID 23806018 DOI: 10.1186/Gm457  0.812
2013 Li M, Durbin KR, Sweet SM, Tipton JD, Zheng Y, Kelleher NL. Oncogene-induced cellular senescence elicits an anti-Warburg effect. Proteomics. 13: 2585-96. PMID 23798001 DOI: 10.1002/Pmic.201200298  0.584
2013 Chen Y, McClure RA, Zheng Y, Thomson RJ, Kelleher NL. Proteomics guided discovery of flavopeptins: anti-proliferative aldehydes synthesized by a reductase domain-containing non-ribosomal peptide synthetase. Journal of the American Chemical Society. 135: 10449-56. PMID 23763305 DOI: 10.1021/Ja4031193  0.715
2013 Yates JR, Kelleher NL. Top down proteomics. Analytical Chemistry. 85: 6151. PMID 23705843 DOI: 10.1021/Ac401484R  0.493
2013 Shaw JB, Li W, Holden DD, Zhang Y, Griep-Raming J, Fellers RT, Early BP, Thomas PM, Kelleher NL, Brodbelt JS. Complete protein characterization using top-down mass spectrometry and ultraviolet photodissociation. Journal of the American Chemical Society. 135: 12646-51. PMID 23697802 DOI: 10.1021/Ja4029654  0.605
2013 Kelleher NL, Paša-Toli? L. 25th ASMS Sanibel Conference on Top Down Mass Spectrometry. Journal of the American Society For Mass Spectrometry. 24: 983-5. PMID 23673522 DOI: 10.1007/S13361-013-0640-Y  0.34
2013 Kelleher NL. Status of mass spectrometry-based proteomics and metabolomics in basic and translational research. Biochemistry. 52: 3794-6. PMID 23614658 DOI: 10.1021/Bi400466P  0.384
2013 Rothmann M, Kang M, Villa R, Ntai I, La Clair JJ, Kelleher NL, Chapman E, Burkart MD. Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme A. Journal of the American Chemical Society. 135: 5962-5. PMID 23550886 DOI: 10.1021/Ja400795M  0.761
2013 Evans BS, Zhao C, Gao J, Evans CM, Ju KS, Doroghazi JR, van der Donk WA, Kelleher NL, Metcalf WW. Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection. Acs Chemical Biology. 8: 908-13. PMID 23474169 DOI: 10.1021/Cb400102T  0.606
2013 Smith LM, Kelleher NL. Proteoform: a single term describing protein complexity. Nature Methods. 10: 186-7. PMID 23443629 DOI: 10.1038/Nmeth.2369  0.31
2013 Chen Y, Unger M, Ntai I, McClure RA, Albright JC, Thomson RJ, Kelleher NL. Gobichelin A and B: Mixed-Ligand Siderophores Discovered Using Proteomics. Medchemcomm. 4: 233-238. PMID 23336063 DOI: 10.1039/C2Md20232H  0.798
2013 Catherman AD, Li M, Tran JC, Durbin KR, Compton PD, Early BP, Thomas PM, Kelleher NL. Top down proteomics of human membrane proteins from enriched mitochondrial fractions. Analytical Chemistry. 85: 1880-8. PMID 23305238 DOI: 10.1021/Ac3031527  0.812
2013 Lee JE, Zamdborg L, Southey BR, Atkins N, Mitchell JW, Li M, Gillette MU, Kelleher NL, Sweedler JV. Quantitative peptidomics for discovery of circadian-related peptides from the rat suprachiasmatic nucleus. Journal of Proteome Research. 12: 585-93. PMID 23256577 DOI: 10.1021/Pr300605P  0.57
2013 Wu X, Vellaichamy A, Wang D, Zamdborg L, Kelleher NL, Huber SC, Zhao Y. Differential lysine acetylation profiles of Erwinia amylovora strains revealed by proteomics. Journal of Proteomics. 79: 60-71. PMID 23234799 DOI: 10.1016/J.Jprot.2012.12.001  0.779
2013 Popovic R, Martinez-Garcia E, Zhang Q, Ezponda T, Shah MY, Zhang Y, Jiang Y, Will CM, Small EC, Bulic M, Elemento O, Kelleher N, Kath W, Wang J, Licht JD. MMSET dysregulates gene expression in myeloma through global and focal changes in H3K36 and H3K27 methylation Epigenetics & Chromatin. 6. DOI: 10.1186/1756-8935-6-S1-P66  0.311
2012 Compton PD, Kelleher NL. Spinning up mass spectrometry for whole protein complexes. Nature Methods. 9: 1065-6. PMID 23132117 DOI: 10.1038/Nmeth.2216  0.41
2012 Park S, Ntai I, Thomas P, Konishcheva E, Kelleher NL, Statsuk AV. Mechanism-based small molecule cross-linkers of HECT E3 ubiquitin ligase-substrate pairs. Biochemistry. 51: 8327-9. PMID 23043241 DOI: 10.1021/Bi301231H  0.72
2012 Jia C, Hui L, Cao W, Lietz CB, Jiang X, Chen R, Catherman AD, Thomas PM, Ge Y, Kelleher NL, Li L. High-definition de novo sequencing of crustacean hyperglycemic hormone (CHH)-family neuropeptides. Molecular & Cellular Proteomics : McP. 11: 1951-64. PMID 23028060 DOI: 10.1074/Mcp.M112.020537  0.819
2012 Kelleher NL. A cell-based approach to the human proteome project. Journal of the American Society For Mass Spectrometry. 23: 1617-24. PMID 22976808 DOI: 10.1007/S13361-012-0469-9  0.361
2012 Fornelli L, Damoc E, Thomas PM, Kelleher NL, Aizikov K, Denisov E, Makarov A, Tsybin YO. Analysis of intact monoclonal antibody IgG1 by electron transfer dissociation Orbitrap FTMS. Molecular & Cellular Proteomics : McP. 11: 1758-67. PMID 22964222 DOI: 10.1074/Mcp.M112.019620  0.599
2012 Zheng Y, Sweet SM, Popovic R, Martinez-Garcia E, Tipton JD, Thomas PM, Licht JD, Kelleher NL. Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3. Proceedings of the National Academy of Sciences of the United States of America. 109: 13549-54. PMID 22869745 DOI: 10.1073/Pnas.1205707109  0.492
2012 Romanova EV, Lee JE, Kelleher NL, Sweedler JV, Gulley JM. Comparative peptidomics analysis of neural adaptations in rats repeatedly exposed to amphetamine. Journal of Neurochemistry. 123: 276-87. PMID 22860605 DOI: 10.1111/J.1471-4159.2012.07912.X  0.332
2012 Shvartsburg AA, Zheng Y, Smith RD, Kelleher NL. Separation of variant methylated histone tails by differential ion mobility. Analytical Chemistry. 84: 6317-20. PMID 22812477 DOI: 10.1021/Ac301541R  0.352
2012 Ahlf DR, Compton PD, Tran JC, Early BP, Thomas PM, Kelleher NL. Evaluation of the compact high-field orbitrap for top-down proteomics of human cells. Journal of Proteome Research. 11: 4308-14. PMID 22746247 DOI: 10.1021/Pr3004216  0.619
2012 Wu C, Tran JC, Zamdborg L, Durbin KR, Li M, Ahlf DR, Early BP, Thomas PM, Sweedler JV, Kelleher NL. A protease for 'middle-down' proteomics. Nature Methods. 9: 822-4. PMID 22706673 DOI: 10.1038/Nmeth.2074  0.728
2012 Shvartsburg AA, Zheng Y, Smith RD, Kelleher NL. Ion mobility separation of variant histone tails extending to the "middle-down" range. Analytical Chemistry. 84: 4271-6. PMID 22559289 DOI: 10.1021/Ac300612Y  0.372
2012 Vagstad AL, Bumpus SB, Belecki K, Kelleher NL, Townsend CA. Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity. Journal of the American Chemical Society. 134: 6865-77. PMID 22452347 DOI: 10.1021/Ja3016389  0.806
2012 Tipton JD, Tran JC, Catherman AD, Ahlf DR, Durbin KR, Lee JE, Kellie JF, Kelleher NL, Hendrickson CL, Marshall AG. Nano-LC FTICR tandem mass spectrometry for top-down proteomics: routine baseline unit mass resolution of whole cell lysate proteins up to 72 kDa. Analytical Chemistry. 84: 2111-7. PMID 22356091 DOI: 10.1021/Ac202651V  0.844
2012 Kellie JF, Catherman AD, Durbin KR, Tran JC, Tipton JD, Norris JL, Witkowski CE, Thomas PM, Kelleher NL. Robust analysis of the yeast proteome under 50 kDa by molecular-mass-based fractionation and top-down mass spectrometry. Analytical Chemistry. 84: 209-15. PMID 22103811 DOI: 10.1021/Ac202384V  0.84
2012 Chen Y, Ntai I, Ju KS, Unger M, Zamdborg L, Robinson SJ, Doroghazi JR, Labeda DP, Metcalf WW, Kelleher NL. A proteomic survey of nonribosomal peptide and polyketide biosynthesis in actinobacteria. Journal of Proteome Research. 11: 85-94. PMID 21978092 DOI: 10.1021/Pr2009115  0.792
2011 Mao Y, Zamdborg L, Kelleher NL, Hendrickson CL, Marshall AG. Identification of Phosphorylated Human Peptides by Accurate Mass Measurement Alone. International Journal of Mass Spectrometry. 308: 357-361. PMID 22866021 DOI: 10.1016/J.Ijms.2011.08.006  0.389
2011 Tran JC, Zamdborg L, Ahlf DR, Lee JE, Catherman AD, Durbin KR, Tipton JD, Vellaichamy A, Kellie JF, Li M, Wu C, Sweet SM, Early BP, Siuti N, LeDuc RD, ... ... Kelleher NL, et al. Mapping intact protein isoforms in discovery mode using top-down proteomics. Nature. 480: 254-8. PMID 22037311 DOI: 10.1038/Nature10575  0.822
2011 Molohon KJ, Melby JO, Lee J, Evans BS, Dunbar KL, Bumpus SB, Kelleher NL, Mitchell DA. Structure determination and interception of biosynthetic intermediates for the plantazolicin class of highly discriminating antibiotics. Acs Chemical Biology. 6: 1307-13. PMID 21950656 DOI: 10.1021/Cb200339D  0.807
2011 Ames BD, Haynes SW, Gao X, Evans BS, Kelleher NL, Tang Y, Walsh CT. Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. Biochemistry. 50: 8756-69. PMID 21899262 DOI: 10.1021/Bi201302W  0.792
2011 Zhang W, Ntai I, Kelleher NL, Walsh CT. tRNA-dependent peptide bond formation by the transferase PacB in biosynthesis of the pacidamycin group of pentapeptidyl nucleoside antibiotics. Proceedings of the National Academy of Sciences of the United States of America. 108: 12249-53. PMID 21746899 DOI: 10.1073/Pnas.1109539108  0.79
2011 Compton PD, Zamdborg L, Thomas PM, Kelleher NL. On the scalability and requirements of whole protein mass spectrometry. Analytical Chemistry. 83: 6868-74. PMID 21744800 DOI: 10.1021/Ac2010795  0.616
2011 Tipton JD, Tran JC, Catherman AD, Ahlf DR, Durbin KR, Kelleher NL. Analysis of intact protein isoforms by mass spectrometry. The Journal of Biological Chemistry. 286: 25451-8. PMID 21632550 DOI: 10.1074/Jbc.R111.239442  0.799
2011 Evans BS, Chen Y, Metcalf WW, Zhao H, Kelleher NL. Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo. Chemistry & Biology. 18: 601-7. PMID 21609841 DOI: 10.1016/J.Chembiol.2011.03.008  0.727
2011 Evans BS, Ntai I, Chen Y, Robinson SJ, Kelleher NL. Proteomics-based discovery of koranimine, a cyclic imine natural product. Journal of the American Chemical Society. 133: 7316-9. PMID 21520944 DOI: 10.1021/Ja2015795  0.805
2011 Hollenhorst MA, Ntai I, Badet B, Kelleher NL, Walsh CT. A head-to-head comparison of eneamide and epoxyamide inhibitors of glucosamine-6-phosphate synthase from the dapdiamide biosynthetic pathway. Biochemistry. 50: 3859-61. PMID 21520904 DOI: 10.1021/Bi2004735  0.776
2011 Zhang W, Ntai I, Bolla ML, Malcolmson SJ, Kahne D, Kelleher NL, Walsh CT. Nine enzymes are required for assembly of the pacidamycin group of peptidyl nucleoside antibiotics. Journal of the American Chemical Society. 133: 5240-3. PMID 21417270 DOI: 10.1021/Ja2011109  0.798
2011 Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD. The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. Blood. 117: 211-20. PMID 20974671 DOI: 10.1182/Blood-2010-07-298349  0.492
2011 Evans BS, Robinson SJ, Kelleher NL. Surveys of non-ribosomal peptide and polyketide assembly lines in fungi and prospects for their analysis in vitro and in vivo. Fungal Genetics and Biology : Fg & B. 48: 49-61. PMID 20601041 DOI: 10.1016/J.Fgb.2010.06.012  0.642
2011 Popovic R, Martinez-Garcia E, Sweet SM, Zheng Y, Kelleher NL, Licht JD. MMSET Contributes to Multiple Myeloma Oncogenesis Through Induction of Global Epigenetic Changes and Alteration of the DNA Damage Response, Blood. 118: 3475-3475. DOI: 10.1182/Blood.V118.21.3475.3475  0.31
2011 Licht JD, Popovic R, Min D, Martinez-Garcia E, Mrksch M, Kelleher N, Will C, Ezponda T. Abstract PL05-02: MMSET: A pathogenic factor and therapeutic target in multiple myeloma. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-Pl05-02  0.323
2010 Hollenhorst MA, Bumpus SB, Matthews ML, Bollinger JM, Kelleher NL, Walsh CT. The nonribosomal peptide synthetase enzyme DdaD tethers N(β)-fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis. Journal of the American Chemical Society. 132: 15773-81. PMID 20945916 DOI: 10.1021/Ja1072367  0.768
2010 Durbin KR, Tran JC, Zamdborg L, Sweet SM, Catherman AD, Lee JE, Li M, Kellie JF, Kelleher NL. Intact mass detection, interpretation, and visualization to automate Top-Down proteomics on a large scale. Proteomics. 10: 3589-97. PMID 20848673 DOI: 10.1002/Pmic.201000177  0.821
2010 Kellie JF, Tran JC, Lee JE, Ahlf DR, Thomas HM, Ntai I, Catherman AD, Durbin KR, Zamdborg L, Vellaichamy A, Thomas PM, Kelleher NL. The emerging process of Top Down mass spectrometry for protein analysis: biomarkers, protein-therapeutics, and achieving high throughput. Molecular Biosystems. 6: 1532-9. PMID 20711533 DOI: 10.1039/C000896F  0.834
2010 Sweet SM, Li M, Thomas PM, Durbin KR, Kelleher NL. Kinetics of re-establishing H3K79 methylation marks in global human chromatin. The Journal of Biological Chemistry. 285: 32778-86. PMID 20699226 DOI: 10.1074/Jbc.M110.145094  0.635
2010 Romanova EV, Lee JE, Kelleher NL, Sweedler JV, Gulley JM. Mass spectrometry screening reveals peptides modulated differentially in the medial prefrontal cortex of rats with disparate initial sensitivity to cocaine. The Aaps Journal. 12: 443-54. PMID 20490734 DOI: 10.1208/S12248-010-9204-2  0.318
2010 Zheng Y, John S, Pesavento JJ, Schultz-Norton JR, Schiltz RL, Baek S, Nardulli AM, Hager GL, Kelleher NL, Mizzen CA. Histone H1 phosphorylation is associated with transcription by RNA polymerases I and II. The Journal of Cell Biology. 189: 407-15. PMID 20439994 DOI: 10.1083/Jcb.201001148  0.711
2010 Johannes TW, DeSieno MA, Griffin BM, Thomas PM, Kelleher NL, Metcalf WW, Zhao H. Deciphering the late biosynthetic steps of antimalarial compound FR-900098. Chemistry & Biology. 17: 57-64. PMID 20142041 DOI: 10.1016/J.Chembiol.2009.12.009  0.496
2010 Vellaichamy A, Tran JC, Catherman AD, Lee JE, Kellie JF, Sweet SM, Zamdborg L, Thomas PM, Ahlf DR, Durbin KR, Valaskovic GA, Kelleher NL. Size-sorting combined with improved nanocapillary liquid chromatography-mass spectrometry for identification of intact proteins up to 80 kDa. Analytical Chemistry. 82: 1234-44. PMID 20073486 DOI: 10.1021/Ac9021083  0.835
2010 Lee JE, Atkins N, Hatcher NG, Zamdborg L, Gillette MU, Sweedler JV, Kelleher NL. Endogenous peptide discovery of the rat circadian clock: a focused study of the suprachiasmatic nucleus by ultrahigh performance tandem mass spectrometry. Molecular & Cellular Proteomics : McP. 9: 285-97. PMID 19955084 DOI: 10.1074/Mcp.M900362-Mcp200  0.342
2010 Siuti N, Kelleher NL. Efficient readout of posttranslational codes on the 50-residue tail of histone H3 by high-resolution MS/MS. Analytical Biochemistry. 396: 180-7. PMID 19761750 DOI: 10.1016/J.Ab.2009.09.022  0.806
2010 Ntai I, Kelleher NL. Approaches for natural product detection and structural elucidation using mass spectrometry with high mass accuracy Methodologies For Metabolomics: Experimental Strategies and Techniques. 174-184. DOI: 10.1017/CBO9780511996634.008  0.691
2009 Li M, Jiang L, Kelleher NL. Global histone profiling by LC-FTMS after inhibition and knockdown of deacetylases in human cells. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 877: 3885-92. PMID 19828382 DOI: 10.1016/J.Jchromb.2009.09.042  0.7
2009 Bumpus SB, Evans BS, Thomas PM, Ntai I, Kelleher NL. A proteomics approach to discovering natural products and their biosynthetic pathways. Nature Biotechnology. 27: 951-6. PMID 19767731 DOI: 10.1038/Nbt.1565  0.806
2009 Lee JE, Kellie JF, Tran JC, Tipton JD, Catherman AD, Thomas HM, Ahlf DR, Durbin KR, Vellaichamy A, Ntai I, Marshall AG, Kelleher NL. A robust two-dimensional separation for top-down tandem mass spectrometry of the low-mass proteome. Journal of the American Society For Mass Spectrometry. 20: 2183-91. PMID 19747844 DOI: 10.1016/J.Jasms.2009.08.001  0.83
2009 Lee MV, Ihnken LA, You YO, McClerren AL, van der Donk WA, Kelleher NL. Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry. Journal of the American Chemical Society. 131: 12258-64. PMID 19663480 DOI: 10.1021/Ja9033507  0.41
2009 Evans BS, Kelleher NL. To cyclize or not to cyclize: catching enzyme evolution in the act. Acs Chemical Biology. 4: 495-7. PMID 19606882 DOI: 10.1021/Cb900154B  0.593
2009 Ferguson JT, Wenger CD, Metcalf WW, Kelleher NL. Top-down proteomics reveals novel protein forms expressed in Methanosarcina acetivorans. Journal of the American Society For Mass Spectrometry. 20: 1743-50. PMID 19577935 DOI: 10.1016/J.Jasms.2009.05.014  0.766
2009 Lee JH, Evans BS, Li G, Kelleher NL, van der Donk WA. In vitro characterization of a heterologously expressed nonribosomal Peptide synthetase involved in phosphinothricin tripeptide biosynthesis. Biochemistry. 48: 5054-6. PMID 19432442 DOI: 10.1021/Bi900164D  0.594
2009 Yang XD, Huang B, Li M, Lamb A, Kelleher NL, Chen LF. Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit. The Embo Journal. 28: 1055-66. PMID 19262565 DOI: 10.1038/Emboj.2009.55  0.538
2009 Kalaitzis JA, Cheng Q, Thomas PM, Kelleher NL, Moore BS. In vitro biosynthesis of unnatural enterocin and wailupemycin polyketides. Journal of Natural Products. 72: 469-72. PMID 19215142 DOI: 10.1021/Np800598T  0.494
2009 Boyne MT, Garcia BA, Li M, Zamdborg L, Wenger CD, Babai S, Kelleher NL. Tandem mass spectrometry with ultrahigh mass accuracy clarifies peptide identification by database retrieval. Journal of Proteome Research. 8: 374-9. PMID 19053528 DOI: 10.1021/Pr800635M  0.816
2008 Wenger CD, Boyne MT, Ferguson JT, Robinson DE, Kelleher NL. Versatile online-offline engine for automated acquisition of high-resolution tandem mass spectra. Analytical Chemistry. 80: 8055-63. PMID 18841935 DOI: 10.1021/Ac8010704  0.834
2008 Mann M, Kelleher NL. Precision proteomics: the case for high resolution and high mass accuracy. Proceedings of the National Academy of Sciences of the United States of America. 105: 18132-8. PMID 18818311 DOI: 10.1073/Pnas.0800788105  0.445
2008 Bora A, Annangudi SP, Millet LJ, Rubakhin SS, Forbes AJ, Kelleher NL, Gillette MU, Sweedler JV. Neuropeptidomics of the supraoptic rat nucleus. Journal of Proteome Research. 7: 4992-5003. PMID 18816085 DOI: 10.1021/Pr800394E  0.529
2008 Calderone CT, Bumpus SB, Kelleher NL, Walsh CT, Magarvey NA. A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both alpha- and beta-ketone reduction during chain growth. Proceedings of the National Academy of Sciences of the United States of America. 105: 12809-14. PMID 18723688 DOI: 10.1073/Pnas.0806305105  0.767
2008 Eliot AC, Griffin BM, Thomas PM, Johannes TW, Kelleher NL, Zhao H, Metcalf WW. Cloning, expression, and biochemical characterization of Streptomyces rubellomurinus genes required for biosynthesis of antimalarial compound FR900098. Chemistry & Biology. 15: 765-70. PMID 18721747 DOI: 10.1016/J.Chembiol.2008.07.010  0.498
2008 Hatcher NG, Atkins N, Annangudi SP, Forbes AJ, Kelleher NL, Gillette MU, Sweedler JV. Mass spectrometry-based discovery of circadian peptides. Proceedings of the National Academy of Sciences of the United States of America. 105: 12527-32. PMID 18719122 DOI: 10.1073/Pnas.0804340105  0.534
2008 Bumpus SB, Kelleher NL. Accessing natural product biosynthetic processes by mass spectrometry. Current Opinion in Chemical Biology. 12: 475-82. PMID 18706516 DOI: 10.1016/J.Cbpa.2008.07.022  0.837
2008 Garcia BA, Thomas CE, Kelleher NL, Mizzen CA. Tissue-specific expression and post-translational modification of histone H3 variants. Journal of Proteome Research. 7: 4225-36. PMID 18700791 DOI: 10.1021/Pr800044Q  0.619
2008 Bumpus SB, Magarvey NA, Kelleher NL, Walsh CT, Calderone CT. Polyunsaturated fatty-acid-like trans-enoyl reductases utilized in polyketide biosynthesis. Journal of the American Chemical Society. 130: 11614-6. PMID 18693732 DOI: 10.1021/Ja8040042  0.777
2008 Magarvey NA, Fortin PD, Thomas PM, Kelleher NL, Walsh CT. Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line. Acs Chemical Biology. 3: 542-54. PMID 18652473 DOI: 10.1021/Cb800085G  0.767
2008 Brodbelt JS, McLafferty FW, Kelleher NL. Focus in honor of Roman Zubarev, recipient of the 2007 Biemann Medal. Journal of the American Society For Mass Spectrometry. 19: 751-2. PMID 18499035 DOI: 10.1016/J.Jasms.2008.04.021  0.406
2008 Crawford JM, Thomas PM, Scheerer JR, Vagstad AL, Kelleher NL, Townsend CA. Deconstruction of iterative multidomain polyketide synthase function. Science (New York, N.Y.). 320: 243-6. PMID 18403714 DOI: 10.1126/Science.1154711  0.49
2008 Pesavento JJ, Bullock CR, LeDuc RD, Mizzen CA, Kelleher NL. Combinatorial modification of human histone H4 quantitated by two-dimensional liquid chromatography coupled with top down mass spectrometry. The Journal of Biological Chemistry. 283: 14927-37. PMID 18381279 DOI: 10.1074/Jbc.M709796200  0.769
2008 Roth MJ, Parks BA, Ferguson JT, Boyne MT, Kelleher NL. "Proteotyping": population proteomics of human leukocytes using top down mass spectrometry. Analytical Chemistry. 80: 2857-66. PMID 18351787 DOI: 10.1021/Ac800141G  0.839
2008 Frank AM, Pesavento JJ, Mizzen CA, Kelleher NL, Pevzner PA. Interpreting top-down mass spectra using spectral alignment. Analytical Chemistry. 80: 2499-505. PMID 18302345 DOI: 10.1021/Ac702324U  0.78
2008 Yang H, Pesavento JJ, Starnes TW, Cryderman DE, Wallrath LL, Kelleher NL, Mizzen CA. Preferential dimethylation of histone H4 lysine 20 by Suv4-20. The Journal of Biological Chemistry. 283: 12085-92. PMID 18296440 DOI: 10.1074/Jbc.M707974200  0.734
2008 Zhang J, Van Lanen SG, Ju J, Liu W, Dorrestein PC, Li W, Kelleher NL, Shen B. A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 1460-5. PMID 18223152 DOI: 10.1073/Pnas.0711625105  0.614
2008 Krusemark CJ, Ferguson JT, Wenger CD, Kelleher NL, Belshaw PJ. Global amine and acid functional group modification of proteins. Analytical Chemistry. 80: 713-20. PMID 18184016 DOI: 10.1021/Ac7019317  0.831
2008 Pesavento JJ, Yang H, Kelleher NL, Mizzen CA. Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle. Molecular and Cellular Biology. 28: 468-86. PMID 17967882 DOI: 10.1128/Mcb.01517-07  0.719
2007 Leduc RD, Kelleher NL. Using ProSight PTM and related tools for targeted protein identification and characterization with high mass accuracy tandem MS data. Current Protocols in Bioinformatics / Editoral Board, Andreas D. Baxevanis ... [Et Al.]. Unit 13.6. PMID 18428787 DOI: 10.1002/0471250953.Bi1306S19  0.476
2007 Astle J, Ferguson JT, German JB, Harrigan GG, Kelleher NL, Kodadek T, Parks BA, Roth MJ, Singletary KW, Wenger CD, Mahady GB. Characterization of proteomic and metabolomic responses to dietary factors and supplements. The Journal of Nutrition. 137: 2787-93. PMID 18029500 DOI: 10.1093/Jn/137.12.2787  0.791
2007 Whitteck JT, Ni W, Griffin BM, Eliot AC, Thomas PM, Kelleher NL, Metcalf WW, van der Donk WA. Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid. Angewandte Chemie (International Ed. in English). 46: 9089-92. PMID 17990255 DOI: 10.1002/Anie.200703810  0.445
2007 Parks BA, Jiang L, Thomas PM, Wenger CD, Roth MJ, Boyne MT, Burke PV, Kwast KE, Kelleher NL. Top-down proteomics on a chromatographic time scale using linear ion trap fourier transform hybrid mass spectrometers. Analytical Chemistry. 79: 7984-91. PMID 17915963 DOI: 10.1021/Ac070553T  0.834
2007 Siuti N, Kelleher NL. Decoding protein modifications using top-down mass spectrometry. Nature Methods. 4: 817-21. PMID 17901871 DOI: 10.1038/Nmeth1097  0.826
2007 Hwang Y, Thompson PR, Wang L, Jiang L, Kelleher NL, Cole PA. A selective chemical probe for coenzyme A-requiring enzymes. Angewandte Chemie (International Ed. in English). 46: 7621-4. PMID 17768748 DOI: 10.1002/Anie.200702485  0.602
2007 Calderone CT, Iwig DF, Dorrestein PC, Kelleher NL, Walsh CT. Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1. Chemistry & Biology. 14: 835-46. PMID 17656320 DOI: 10.1016/J.Chembiol.2007.06.008  0.768
2007 Jiang L, Smith JN, Anderson SL, Ma P, Mizzen CA, Kelleher NL. Global assessment of combinatorial post-translational modification of core histones in yeast using contemporary mass spectrometry. LYS4 trimethylation correlates with degree of acetylation on the same H3 tail. The Journal of Biological Chemistry. 282: 27923-34. PMID 17652096 DOI: 10.1074/Jbc.M704194200  0.57
2007 Blodgett JA, Thomas PM, Li G, Velasquez JE, van der Donk WA, Kelleher NL, Metcalf WW. Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. Nature Chemical Biology. 3: 480-5. PMID 17632514 DOI: 10.1038/Nchembio.2007.9  0.516
2007 Zamdborg L, LeDuc RD, Glowacz KJ, Kim YB, Viswanathan V, Spaulding IT, Early BP, Bluhm EJ, Babai S, Kelleher NL. ProSight PTM 2.0: improved protein identification and characterization for top down mass spectrometry. Nucleic Acids Research. 35: W701-6. PMID 17586823 DOI: 10.1093/Nar/Gkm371  0.47
2007 Pesavento JJ, Garcia BA, Streeky JA, Kelleher NL, Mizzen CA. Mild performic acid oxidation enhances chromatographic and top down mass spectrometric analyses of histones. Molecular & Cellular Proteomics : McP. 6: 1510-26. PMID 17569892 DOI: 10.1074/Mcp.M600404-Mcp200  0.792
2007 Garcia BA, Pesavento JJ, Mizzen CA, Kelleher NL. Pervasive combinatorial modification of histone H3 in human cells. Nature Methods. 4: 487-9. PMID 17529979 DOI: 10.1038/Nmeth1052  0.773
2007 Hansen DB, Bumpus SB, Aron ZD, Kelleher NL, Walsh CT. The loading module of mycosubtilin: an adenylation domain with fatty acid selectivity. Journal of the American Chemical Society. 129: 6366-7. PMID 17472382 DOI: 10.1021/Ja070890J  0.782
2007 Yin J, Straight PD, Hrvatin S, Dorrestein PC, Bumpus SB, Jao C, Kelleher NL, Kolter R, Walsh CT. Genome-wide high-throughput mining of natural-product biosynthetic gene clusters by phage display. Chemistry & Biology. 14: 303-12. PMID 17379145 DOI: 10.1016/J.Chembiol.2007.01.006  0.794
2007 Kelly WL, Boyne MT, Yeh E, Vosburg DA, Galoni? DP, Kelleher NL, Walsh CT. Characterization of the aminocarboxycyclopropane-forming enzyme CmaC. Biochemistry. 46: 359-68. PMID 17209546 DOI: 10.1021/Bi061930J  0.795
2007 Garcia BA, Siuti N, Thomas CE, Mizzen CA, Kelleher NL. Characterization of neurohistone variants and post-translational modifications by electron capture dissociation mass spectrometry International Journal of Mass Spectrometry. 259: 184-196. DOI: 10.1016/J.Ijms.2006.07.022  0.8
2006 Hemp J, Robinson DE, Ganesan KB, Martinez TJ, Kelleher NL, Gennis RB. Evolutionary migration of a post-translationally modified active-site residue in the proton-pumping heme-copper oxygen reductases. Biochemistry. 45: 15405-10. PMID 17176062 DOI: 10.1021/Bi062026U  0.52
2006 Hicks LM, Moffitt MC, Beer LL, Moore BS, Kelleher NL. Structural characterization of in vitro and in vivo intermediates on the loading module of microcystin synthetase. Acs Chemical Biology. 1: 93-102. PMID 17163649 DOI: 10.1021/Cb500007V  0.675
2006 Dorrestein PC, Kelleher NL. Dissecting non-ribosomal and polyketide biosynthetic machineries using electrospray ionization Fourier-Transform mass spectrometry. Natural Product Reports. 23: 893-918. PMID 17119639 DOI: 10.1039/B511400B  0.67
2006 Woodyer RD, Shao Z, Thomas PM, Kelleher NL, Blodgett JA, Metcalf WW, van der Donk WA, Zhao H. Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. Chemistry & Biology. 13: 1171-82. PMID 17113999 DOI: 10.1016/J.Chembiol.2006.09.007  0.485
2006 McClerren AL, Cooper LE, Quan C, Thomas PM, Kelleher NL, van der Donk WA. Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proceedings of the National Academy of Sciences of the United States of America. 103: 17243-8. PMID 17085596 DOI: 10.1073/Pnas.0606088103  0.702
2006 Karanam B, Jiang L, Wang L, Kelleher NL, Cole PA. Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation. The Journal of Biological Chemistry. 281: 40292-301. PMID 17065153 DOI: 10.1074/Jbc.M608813200  0.631
2006 Dorrestein PC, Bumpus SB, Calderone CT, Garneau-Tsodikova S, Aron ZD, Straight PD, Kolter R, Walsh CT, Kelleher NL. Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry. Biochemistry. 45: 12756-66. PMID 17042494 DOI: 10.1021/Bi061169D  0.825
2006 Garneau-Tsodikova S, Dorrestein PC, Kelleher NL, Walsh CT. Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J. Journal of the American Chemical Society. 128: 12600-1. PMID 17002325 DOI: 10.1021/Ja063611L  0.788
2006 Chan YA, Boyne MT, Podevels AM, Klimowicz AK, Handelsman J, Kelleher NL, Thomas MG. Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units. Proceedings of the National Academy of Sciences of the United States of America. 103: 14349-54. PMID 16983083 DOI: 10.1073/Pnas.0603748103  0.744
2006 Romanova EV, Roth MJ, Rubakhin SS, Jakubowski JA, Kelley WP, Kirk MD, Kelleher NL, Sweedler JV. Identification and characterization of homologues of vertebrate beta-thymosin in the marine mollusk Aplysia californica. Journal of Mass Spectrometry : Jms. 41: 1030-40. PMID 16924592 DOI: 10.1002/Jms.1060  0.496
2006 Dorrestein PC, Van Lanen SG, Li W, Zhao C, Deng Z, Shen B, Kelleher NL. The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis. Journal of the American Chemical Society. 128: 10386-7. PMID 16895402 DOI: 10.1021/Ja0639362  0.668
2006 Van Lanen SG, Lin S, Dorrestein PC, Kelleher NL, Shen B. Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027. The Journal of Biological Chemistry. 281: 29633-40. PMID 16887797 DOI: 10.1074/Jbc.M605887200  0.602
2006 Garcia BA, Joshi S, Thomas CE, Chitta RK, Diaz RL, Busby SA, Andrews PC, Ogorzalek Loo RR, Shabanowitz J, Kelleher NL, Mizzen CA, Allis CD, Hunt DF. Comprehensive phosphoprotein analysis of linker histone H1 from Tetrahymena thermophila. Molecular & Cellular Proteomics : McP. 5: 1593-609. PMID 16835217 DOI: 10.1074/Mcp.M600086-Mcp200  0.713
2006 Hicks LM, Balibar CJ, Walsh CT, Kelleher NL, Hillson NJ. Probing intra- versus interchain kinetic preferences of L-Thr acylation on dimeric VibF with mass spectrometry. Biophysical Journal. 91: 2609-19. PMID 16815901 DOI: 10.1529/Biophysj.106.084848  0.804
2006 Pesavento JJ, Mizzen CA, Kelleher NL. Quantitative analysis of modified proteins and their positional isomers by tandem mass spectrometry: human histone H4. Analytical Chemistry. 78: 4271-80. PMID 16808433 DOI: 10.1021/Ac0600050  0.774
2006 Calderone CT, Kowtoniuk WE, Kelleher NL, Walsh CT, Dorrestein PC. Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America. 103: 8977-82. PMID 16757561 DOI: 10.1073/Pnas.0603148103  0.755
2006 Hicks LM, Mazur MT, Miller LM, Dorrestein PC, Schnarr NA, Khosla C, Kelleher NL. Investigating nonribosomal peptide and polyketide biosynthesis by direct detection of intermediates on >70 kDa polypeptides by using Fourier-transform mass spectrometry. Chembiochem : a European Journal of Chemical Biology. 7: 904-7. PMID 16642537 DOI: 10.1002/Cbic.200500416  0.81
2006 Howarth M, Chinnapen DJ, Gerrow K, Dorrestein PC, Grandy MR, Kelleher NL, El-Husseini A, Ting AY. A monovalent streptavidin with a single femtomolar biotin binding site. Nature Methods. 3: 267-73. PMID 16554831 DOI: 10.1038/Nmeth861  0.58
2006 Gatto GJ, Boyne MT, Kelleher NL, Walsh CT. Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster. Journal of the American Chemical Society. 128: 3838-47. PMID 16536560 DOI: 10.1021/Ja0587603  0.751
2006 Dorrestein PC, Blackhall J, Straight PD, Fischbach MA, Garneau-Tsodikova S, Edwards DJ, McLaughlin S, Lin M, Gerwick WH, Kolter R, Walsh CT, Kelleher NL. Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. Biochemistry. 45: 1537-46. PMID 16460000 DOI: 10.1021/Bi052333K  0.814
2006 Boyne MT, Pesavento JJ, Mizzen CA, Kelleher NL. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. Journal of Proteome Research. 5: 248-53. PMID 16457589 DOI: 10.1021/Pr050269N  0.792
2006 Thomas CE, Kelleher NL, Mizzen CA. Mass spectrometric characterization of human histone H3: a bird's eye view. Journal of Proteome Research. 5: 240-7. PMID 16457588 DOI: 10.1021/Pr050266A  0.536
2006 Siuti N, Roth MJ, Mizzen CA, Kelleher NL, Pesavento JJ. Gene-specific characterization of human histone H2B by electron capture dissociation. Journal of Proteome Research. 5: 233-9. PMID 16457587 DOI: 10.1021/Pr050268V  0.795
2006 Miller LM, Chatterjee C, van der Donk WA, Kelleher NL. The dehydratase activity of lacticin 481 synthetase is highly processive. Journal of the American Chemical Society. 128: 1420-1. PMID 16448091 DOI: 10.1021/Ja057203D  0.572
2006 Du Y, Parks BA, Sohn S, Kwast KE, Kelleher NL. Top-down approaches for measuring expression ratios of intact yeast proteins using Fourier transform mass spectrometry. Analytical Chemistry. 78: 686-94. PMID 16448040 DOI: 10.1021/Ac050993P  0.733
2006 Zhang Z, An X, Yang K, Perlstein DL, Hicks L, Kelleher N, Stubbe J, Huang M. Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein. Proceedings of the National Academy of Sciences of the United States of America. 103: 1422-7. PMID 16432237 DOI: 10.1073/Pnas.0510516103  0.6
2006 Patrie SM, Ferguson JT, Robinson DE, Whipple D, Rother M, Metcalf WW, Kelleher NL. Top down mass spectrometry of < 60-kDa proteins from Methanosarcina acetivorans using quadrupole FRMS with automated octopole collisionally activated dissociation. Molecular & Cellular Proteomics : McP. 5: 14-25. PMID 16236702 DOI: 10.1074/Mcp.M500219-Mcp200  0.833
2005 Chatterjee C, Miller LM, Leung YL, Xie L, Yi M, Kelleher NL, van der Donk WA. Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production. Journal of the American Chemical Society. 127: 15332-3. PMID 16262372 DOI: 10.1021/Ja0543043  0.538
2005 Zabrouskov V, Senko MW, Du Y, Leduc RD, Kelleher NL. New and automated MSn approaches for top-down identification of modified proteins. Journal of the American Society For Mass Spectrometry. 16: 2027-38. PMID 16253516 DOI: 10.1016/J.Jasms.2005.08.004  0.595
2005 Aron ZD, Dorrestein PC, Blackhall JR, Kelleher NL, Walsh CT. Characterization of a new tailoring domain in polyketide biogenesis: the amine transferase domain of MycA in the mycosubtilin gene cluster. Journal of the American Chemical Society. 127: 14986-7. PMID 16248612 DOI: 10.1021/Ja055247G  0.713
2005 McLoughlin SM, Kelleher NL. Monitoring multiple active sites on thiotemplate enzymes in parallel: a molecular movie of yersiniabactin bioassembly. Journal of the American Chemical Society. 127: 14984-5. PMID 16248611 DOI: 10.1021/Ja0555264  0.766
2005 McLoughlin SM, Mazur MT, Miller LM, Yin J, Liu F, Walsh CT, Kelleher NL. Chemoenzymatic approaches for streamlined detection of active site modifications on thiotemplate assembly lines using mass spectrometry. Biochemistry. 44: 14159-69. PMID 16245932 DOI: 10.1021/Bi051202G  0.807
2005 Yin J, Straight PD, McLoughlin SM, Zhou Z, Lin AJ, Golan DE, Kelleher NL, Kolter R, Walsh CT. Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase. Proceedings of the National Academy of Sciences of the United States of America. 102: 15815-20. PMID 16236721 DOI: 10.1073/Pnas.0507705102  0.819
2005 Miller LM, Mazur MT, McLoughlin SM, Kelleher NL. Parallel interrogation of covalent intermediates in the biosynthesis of gramicidin S using high-resolution mass spectrometry. Protein Science : a Publication of the Protein Society. 14: 2702-12. PMID 16195555 DOI: 10.1110/Ps.051553705  0.83
2005 Dorrestein PC, Yeh E, Garneau-Tsodikova S, Kelleher NL, Walsh CT. Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 102: 13843-8. PMID 16162666 DOI: 10.1073/Pnas.0506964102  0.819
2005 Kelleher NL, Hicks LM. Contemporary mass spectrometry for the direct detection of enzyme intermediates. Current Opinion in Chemical Biology. 9: 424-30. PMID 16129650 DOI: 10.1016/J.Cbpa.2005.08.018  0.674
2005 Van Lanen SG, Dorrestein PC, Christenson SD, Liu W, Ju J, Kelleher NL, Shen B. Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates. Journal of the American Chemical Society. 127: 11594-5. PMID 16104723 DOI: 10.1021/Ja052871K  0.593
2005 Frankel BA, Kruger RG, Robinson DE, Kelleher NL, McCafferty DG. Staphylococcus aureus sortase transpeptidase SrtA: insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism. Biochemistry. 44: 11188-200. PMID 16101303 DOI: 10.1021/Bi050141J  0.7
2005 Roth MJ, Forbes AJ, Boyne MT, Kim YB, Robinson DE, Kelleher NL. Precise and parallel characterization of coding polymorphisms, alternative splicing, and modifications in human proteins by mass spectrometry. Molecular & Cellular Proteomics : McP. 4: 1002-8. PMID 15863400 DOI: 10.1074/Mcp.M500064-Mcp200  0.841
2005 Gatto GJ, McLoughlin SM, Kelleher NL, Walsh CT. Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme. Biochemistry. 44: 5993-6002. PMID 15835888 DOI: 10.1021/Bi050230W  0.802
2005 Garneau S, Dorrestein PC, Kelleher NL, Walsh CT. Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis. Biochemistry. 44: 2770-80. PMID 15723521 DOI: 10.1021/Bi0476329  0.727
2005 Meng F, Forbes AJ, Miller LM, Kelleher NL. Detection and localization of protein modifications by high resolution tandem mass spectrometry. Mass Spectrometry Reviews. 24: 126-34. PMID 15389861 DOI: 10.1002/Mas.20009  0.779
2004 McLoughlin SM, Kelleher NL. Kinetic and regiospecific interrogation of covalent intermediates in the nonribosomal peptide synthesis of yersiniabactin. Journal of the American Chemical Society. 126: 13265-75. PMID 15479080 DOI: 10.1021/Ja0470867  0.788
2004 Du Y, Meng F, Patrie SM, Miller LM, Kelleher NL. Improved molecular weight-based processing of intact proteins for interrogation by quadrupole-enhanced FT MS/MS. Journal of Proteome Research. 3: 801-6. PMID 15359734 DOI: 10.1021/Pr0499489  0.837
2004 Patrie SM, Charlebois JP, Whipple D, Kelleher NL, Hendrickson CL, Quinn JP, Marshall AG, Mukhopadhyay B. Construction of a hybrid quadrupole/Fourier transform ion cyclotron resonance mass spectrometer for versatile MS/MS above 10 kDa. Journal of the American Society For Mass Spectrometry. 15: 1099-108. PMID 15234368 DOI: 10.1016/J.Jasms.2004.04.031  0.738
2004 LeDuc RD, Taylor GK, Kim YB, Januszyk TE, Bynum LH, Sola JV, Garavelli JS, Kelleher NL. ProSight PTM: an integrated environment for protein identification and characterization by top-down mass spectrometry. Nucleic Acids Research. 32: W340-5. PMID 15215407 DOI: 10.1093/Nar/Gkh447  0.452
2004 Meng F, Du Y, Miller LM, Patrie SM, Robinson DE, Kelleher NL. Molecular-level description of proteins from saccharomyces cerevisiae using quadrupole FT hybrid mass spectrometry for top down proteomics. Analytical Chemistry. 76: 2852-8. PMID 15144197 DOI: 10.1021/Ac0354903  0.838
2004 Hicks LM, O'Connor SE, Mazur MT, Walsh CT, Kelleher NL. Mass spectrometric interrogation of thioester-bound intermediates in the initial stages of epothilone biosynthesis. Chemistry & Biology. 11: 327-35. PMID 15123262 DOI: 10.1016/J.Chembiol.2004.02.021  0.817
2004 Pesavento JJ, Kim YB, Taylor GK, Kelleher NL. Shotgun annotation of histone modifications: a new approach for streamlined characterization of proteins by top down mass spectrometry. Journal of the American Chemical Society. 126: 3386-7. PMID 15025441 DOI: 10.1021/Ja039748I  0.782
2004 Forbes AJ, Patrie SM, Taylor GK, Kim YB, Jiang L, Kelleher NL. Targeted analysis and discovery of posttranslational modifications in proteins from methanogenic archaea by top-down MS. Proceedings of the National Academy of Sciences of the United States of America. 101: 2678-83. PMID 14976258 DOI: 10.1073/Pnas.0306575101  0.841
2004 Xie L, Miller LM, Chatterjee C, Averin O, Kelleher NL, van der Donk WA. Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity. Science (New York, N.Y.). 303: 679-81. PMID 14752162 DOI: 10.1126/Science.1092600  0.578
2004 Tseng CC, McLoughlin SM, Kelleher NL, Walsh CT. Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase. Biochemistry. 43: 970-80. PMID 14744141 DOI: 10.1021/Bi035714B  0.782
2004 Kelleher NL. Peer Reviewed: Top-Down Proteomics Analytical Chemistry. 76: 196 A-203 A. DOI: 10.1021/Ac0415657  0.429
2004 Patrie SM, Robinson DE, Meng F, Du Y, Kelleher NL. Strategies for automating top-down protein analysis with Q-FTICR MS International Journal of Mass Spectrometry. 234: 175-184. DOI: 10.1016/J.Ijms.2004.02.020  0.84
2003 Taylor GK, Kim YB, Forbes AJ, Meng F, McCarthy R, Kelleher NL. Web and database software for identification of intact proteins using "top down" mass spectrometry. Analytical Chemistry. 75: 4081-6. PMID 14632120 DOI: 10.1021/Ac0341721  0.69
2003 Mazur MT, Walsh CT, Kelleher NL. Site-specific observation of acyl intermediate processing in thiotemplate biosynthesis by fourier transform mass spectrometry: the polyketide module of yersiniabactin synthetase. Biochemistry. 42: 13393-400. PMID 14621984 DOI: 10.1021/Bi035585Z  0.781
2003 He S, Bauman D, Davis JS, Loyola A, Nishioka K, Gronlund JL, Reinberg D, Meng F, Kelleher N, McCafferty DG. Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis. Proceedings of the National Academy of Sciences of the United States of America. 100: 12033-8. PMID 14530408 DOI: 10.1073/Pnas.2035256100  0.72
2003 Charlebois JP, Patrie SM, Kelleher NL. Electron capture dissociation and 13C,15N depletion for deuterium localization in intact proteins after solution-phase exchange. Analytical Chemistry. 75: 3263-6. PMID 12964778 DOI: 10.1021/Ac020690K  0.721
2003 Hicks L, Weinreb P, Konz D, Marahiel MA, Walsh CT, Kelleher NL. Fourier-transform mass spectrometry for detection of thioester-bound intermediates in unfractionated proteolytic mixtures of 80 and 191 kDa portions of Bacitracin A synthetase Analytica Chimica Acta. 496: 217-224. DOI: 10.1016/S0003-2670(03)01001-8  0.749
2002 Johnson JR, Meng F, Forbes AJ, Cargile BJ, Kelleher NL. Fourier-transform mass spectrometry for automated fragmentation and identification of 5-20 kDa proteins in mixtures. Electrophoresis. 23: 3217-23. PMID 12298093 DOI: 10.1002/1522-2683(200209)23:18<3217::Aid-Elps3217>3.0.Co;2-K  0.839
2002 Meng F, Cargile BJ, Patrie SM, Johnson JR, McLoughlin SM, Kelleher NL. Processing complex mixtures of intact proteins for direct analysis by mass spectrometry. Analytical Chemistry. 74: 2923-9. PMID 12141648 DOI: 10.1021/Ac020049I  0.836
2002 Valaskovic GA, Kelleher NL. Miniaturized formats for efficient mass spectrometry-based proteomics and therapeutic development. Current Topics in Medicinal Chemistry. 2: 1-12. PMID 11899062 DOI: 10.2174/1568026023394597  0.454
2001 Forbes AJ, Mazur MT, Patel HM, Walsh CT, Kelleher NL. Toward efficient analysis of >70 kDa proteins with 100% sequence coverage. Proteomics. 1: 927-33. PMID 11683509 DOI: 10.1255/Ejms.393  0.834
2001 Meng F, Cargile BJ, Miller LM, Forbes AJ, Johnson JR, Kelleher NL. Informatics and multiplexing of intact protein identification in bacteria and the archaea. Nature Biotechnology. 19: 952-7. PMID 11581661 DOI: 10.1038/Nbt1001-952  0.835
2000 Zubarev RA, Horn DM, Fridriksson EK, Kelleher NL, Kruger NA, Lewis MA, Carpenter BK, McLafferty FW. Electron capture dissociation for structural characterization of multiply charged protein cations. Analytical Chemistry. 72: 563-73. PMID 10695143 DOI: 10.1021/Ac990811P  0.647
2000 Kelleher NL. From primary structure to function: biological insights from large-molecule mass spectra. Chemistry & Biology. 7: R37-45. PMID 10662697 DOI: 10.1016/S1074-5521(00)00081-8  0.413
1999 Kelleher NL, Hendrickson CL, Walsh CT. Posttranslational heterocyclization of cysteine and serine residues in the antibiotic microcin B17: distributivity and directionality. Biochemistry. 38: 15623-30. PMID 10569947 DOI: 10.1021/Bi9913698  0.583
1999 Kelleher NL, Zubarev RA, Bush K, Furie B, Furie BC, McLafferty FW, Walsh CT. Localization of labile posttranslational modifications by electron capture dissociation: the case of gamma-carboxyglutamic acid. Analytical Chemistry. 71: 4250-3. PMID 10517147 DOI: 10.1021/Ac990684X  0.694
1999 Shaw-Reid CA, Kelleher NL, Losey HC, Gehring AM, Berg C, Walsh CT. Assembly line enzymology by multimodular nonribosomal peptide synthetases: the thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization. Chemistry & Biology. 6: 385-400. PMID 10375542 DOI: 10.1016/S1074-5521(99)80050-7  0.805
1999 Sinha Roy R, Kelleher NL, Milne JC, Walsh CT. In vivo processing and antibiotic activity of microcin B17 analogs with varying ring content and altered bisheterocyclic sites. Chemistry & Biology. 6: 305-18. PMID 10322125 DOI: 10.1016/S1074-5521(99)80076-3  0.565
1999 Milne JC, Roy RS, Eliot AC, Kelleher NL, Wokhlu A, Nickels B, Walsh CT. Cofactor requirements and reconstitution of microcin B17 synthetase: a multienzyme complex that catalyzes the formation of oxazoles and thiazoles in the antibiotic microcin B17. Biochemistry. 38: 4768-81. PMID 10200165 DOI: 10.1021/Bi982975Q  0.591
1999 Kelleher NL, Lin HY, Valaskovic GA, Aaserud DJ, Fridriksson EK, McLafferty FW. Top down versus bottom up protein characterization by tandem high- resolution mass spectrometry Journal of the American Chemical Society. 121: 806-812. DOI: 10.1021/Ja973655H  0.618
1999 Kruger NA, Zubarev RA, Carpenter BK, Kelleher NL, Horn DM, McLafferty FW. Electron capture versus energetic dissociation of protein ions International Journal of Mass Spectrometry. 182: 1-5. DOI: 10.1016/S1387-3806(98)14260-4  0.656
1999 Shaw-Reid CA, Kelleher NL, Losey HC, Gehring AM, Berg C, Walsh CT. Erratum: Assembly line enzymology by multimodular nonribosomal peptide synthetases: The thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization (Chemistry and Biology (1999) 6 (385-400)) Chemistry & Biology. 6. DOI: 10.1016/S1074-5521(00)80026-5  0.782
1998 Kinsland C, Taylor SV, Kelleher NL, McLafferty FW, Begley TP. Overexpression of recombinant proteins with a C-terminal thiocarboxylate: implications for protein semisynthesis and thiamin biosynthesis. Protein Science : a Publication of the Protein Society. 7: 1839-42. PMID 10082383 DOI: 10.1002/Pro.5560070821  0.808
1998 Kelleher NL, Taylor SV, Grannis D, Kinsland C, Chiu HJ, Begley TP, McLafferty FW. Efficient sequence analysis of the six gene products (7-74 kDa) from the Escherichia coli thiamin biosynthetic operon by tandem high-resolution mass spectrometry. Protein Science : a Publication of the Protein Society. 7: 1796-801. PMID 10082377 DOI: 10.1002/Pro.5560070815  0.829
1998 McLafferty FW, Kelleher NL, Begley TP, Fridriksson EK, Zubarev RA, Horn DM. Two-dimensional mass spectrometry of biomolecules at the subfemtomole level. Current Opinion in Chemical Biology. 2: 571-8. PMID 9818181 DOI: 10.1016/S1367-5931(98)80085-9  0.77
1998 Milne JC, Eliot AC, Kelleher NL, Walsh CT. ATP/GTP hydrolysis is required for oxazole and thiazole biosynthesis in the peptide antibiotic microcin B17. Biochemistry. 37: 13250-61. PMID 9748332 DOI: 10.1021/Bi980996E  0.577
1998 Belshaw PJ, Roy RS, Kelleher NL, Walsh CT. Kinetics and regioselectivity of peptide-to-heterocycle conversions by microcin B17 synthetase. Chemistry & Biology. 5: 373-84. PMID 9662507 DOI: 10.1016/S1074-5521(98)90071-0  0.786
1998 Taylor SV, Kelleher NL, Kinsland C, Chiu HJ, Costello CA, Backstrom AD, McLafferty FW, Begley TP. Thiamin biosynthesis in Escherichia coli. Identification of ThiS thiocarboxylate as the immediate sulfur donor in the thiazole formation. The Journal of Biological Chemistry. 273: 16555-60. PMID 9632726 DOI: 10.1074/Jbc.273.26.16555  0.792
1998 Kelleher NL, Belshaw PJ, Walsh CT. Regioselectivity and Chemoselectivity Analysis of Oxazole and Thiazole Ring Formation by the Peptide-Heterocyclizing Microcin B17 Synthetase Using High-Resolution MS/MS Journal of the American Chemical Society. 120: 9716-9717. DOI: 10.1021/Ja9822097  0.772
1998 Zubarev RA, Kelleher NL, McLafferty FW. Electron capture dissociation of multiply charged protein cations. A nonergodic process Journal of the American Chemical Society. 120: 3265-3266. DOI: 10.1021/Ja973478K  0.521
1998 McLafferty FW, Guan Z, Haupts U, Wood TD, Kelleher NL. Gaseous conformational structures of cytochrome c Journal of the American Chemical Society. 120: 4732-4740. DOI: 10.1021/Ja9728076  0.669
1997 Kelleher NL, Nicewonger RB, Begley TP, McLafferty FW. Identification of modification sites in large biomolecules by stable isotope labeling and tandem high resolution mass spectrometry. The active site nucleophile of thiaminase I. The Journal of Biological Chemistry. 272: 32215-20. PMID 9405424 DOI: 10.1074/Jbc.272.51.32215  0.723
1997 Kelleher NL, Senko MW, Siegel MM, McLafferty FW. Unit resolution mass spectra of 112 kDa molecules with 3 Da accuracy Journal of the American Society For Mass Spectrometry. 8: 380-383. DOI: 10.1016/S1044-0305(97)00060-3  0.527
1997 McLafferty FW, Aaserud DJ, Guan Z, Little DP, Kelleher NL. Double stranded DNA sequencing by tandem mass spectrometry International Journal of Mass Spectrometry and Ion Processes. 165: 457-466. DOI: 10.1016/S0168-1176(97)00171-7  0.514
1996 Aaserud DJ, Kelleher NL, Little DP, McLafferty FW. Accurate base composition of double-strand DNA by mass spectrometry. Journal of the American Society For Mass Spectrometry. 7: 1266-9. PMID 24203160 DOI: 10.1016/S1044-0305(96)00194-8  0.508
1996 Mørtz E, O'Connor PB, Roepstorff P, Kelleher NL, Wood TD, McLafferty FW, Mann M. Sequence tag identification of intact proteins by matching tanden mass spectral data against sequence data bases. Proceedings of the National Academy of Sciences of the United States of America. 93: 8264-7. PMID 8710858 DOI: 10.1073/Pnas.93.16.8264  0.782
1996 Valaskovic GA, Kelleher NL, McLafferty FW. Attomole protein characterization by capillary electrophoresis-mass spectrometry. Science (New York, N.Y.). 273: 1199-202. PMID 8703047 DOI: 10.1126/Science.273.5279.1199  0.559
1996 Costello CA, Kelleher NL, Abe M, McLafferty FW, Begley TP. Mechanistic studies on thiaminase I. Overexpression and identification of the active site nucleophile. The Journal of Biological Chemistry. 271: 3445-52. PMID 8631946 DOI: 10.1074/Jbc.271.7.3445  0.685
1996 Guan Z, Kelleher NL, O'Connor PB, Aaserud DJ, Little DP, McLafferty FW. 193 nm photodissociation of larger multiply-charged biomolecules International Journal of Mass Spectrometry and Ion Processes. 157: 357-364. DOI: 10.1016/S0168-1176(96)04399-6  0.619
1995 Kelleher NL, Senko MW, Little DP, O'Connor PB, McLafferty FW. Complete large-molecule high-resolution mass spectra from 50-femtomole microvolume injection. Journal of the American Society For Mass Spectrometry. 6: 220-1. PMID 24214121 DOI: 10.1016/1044-0305(95)00088-U  0.639
1995 Kelleher NL, Costello CA, Begley TP, McLafferty FW. Thiaminase I (42 kDa) heterogeneity, sequence refinement, and active site location from high-resolution tandem mass spectrometry. Journal of the American Society For Mass Spectrometry. 6: 981-4. PMID 24214043 DOI: 10.1016/1044-0305(95)00584-Z  0.702
1995 Wood TD, Chen LH, Kelleher NL, Little DP, Kenyon GL, McLafferty FW. Direct sequence data from heterogeneous creatine kinase (43 kDa) by high-resolution tandem mass spectrometry. Biochemistry. 34: 16251-4. PMID 8845349 DOI: 10.1021/Bi00050A004  0.699
1995 Valaskovic GA, Kelleher NL, Little DP, Aaserud DJ, McLafferty FW. Attomole-sensitivity electrospray source for large-molecule mass spectrometry. Analytical Chemistry. 67: 3802-5. PMID 8644926 DOI: 10.1021/Ac00116A030  0.55
1994 Little DP, Chorush RA, Speir JP, Senko MW, Kelleher NL, McLafferty FW. Rapid sequencing of oligonucleotides by high-resolution mass spectrometry Journal of the American Chemical Society. 116: 4893-4897. DOI: 10.1021/Ja00090A039  0.533
Show low-probability matches.