Arvum Spira - Publications

Affiliations: 
Boston University, Boston, MA, United States 
Area:
Biostatistics Biology, Genetics, Oncology, Toxicology

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Year Citation  Score
2021 Xu K, Shi X, Husted C, Hong R, Wang Y, Ning B, Sullivan T, Rieger-Christ K, Duan F, Marques H, Gower A, Xiao X, Liu H, Liu G, Duclos G, ... Spira A, et al. Smoking Modulates Different Secretory Subpopulations Expressing SARS-CoV-2 Entry Genes in the Nasal and Bronchial Airways. Research Square. PMID 34729557 DOI: 10.21203/rs.3.rs-887718/v1  0.704
2021 Maoz A, Merenstein C, Koga Y, Potter A, Gower AC, Liu G, Zhang S, Liu H, Stevenson C, Spira A, Reid ME, Campbell JD, Mazzilli SA, Lenburg ME, Beane J. Elevated T cell repertoire diversity is associated with progression of lung squamous cell premalignant lesions. Journal For Immunotherapy of Cancer. 9. PMID 34580161 DOI: 10.1136/jitc-2021-002647  0.658
2021 Becker EJ, Faiz A, van den Berge M, Timens W, Hiemstra PS, Clark K, Liu G, Xiao X, Alekseyev YO, O'Connor G, Lam S, Spira A, Lenburg ME, Steiling K. Bronchial gene expression signature associated with rate of subsequent FEV decline in individuals with and at risk of COPD. Thorax. PMID 33972452 DOI: 10.1136/thoraxjnl-2019-214476  0.371
2021 Tilston-Lunel A, Mazzilli S, Kingston NM, Szymaniak AD, Hicks-Berthet J, Kern JG, Abo K, Reid ME, Perdomo C, Wilson AA, Spira A, Beane J, Varelas X. Aberrant epithelial polarity cues drive the development of precancerous airway lesions. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33903236 DOI: 10.1073/pnas.2019282118  0.688
2021 Han G, Sinjab A, Hara K, Treekitkarnmongkol W, Brennan P, Chang K, Bogatenkova E, Sanchez-Espiridion B, Behrens C, Solis LM, Gao B, Girard L, Zhang J, Sepesi B, Cascone T, ... ... Spira AE, et al. Single-Cell Expression Landscape of SARS-CoV-2 Receptor and Host Proteases in Normal and Malignant Lung Tissues from Pulmonary Adenocarcinoma Patients. Cancers. 13. PMID 33809063 DOI: 10.3390/cancers13061250  0.457
2021 Mazzone PJ, Lamb C, Rieger-Christ KM, Reddy CB, Qu J, Wu S, Ding J, Whitney D, Pankratz DG, Babiarz J, Lofaro L, Walsh PS, Wilde J, Bhorade SM, Huang J, ... ... Spira A, et al. Early candidate nasal swab classifiers developed using machine learning and whole transcriptome sequencing may improve early lung cancer detection. Journal of Clinical Oncology. 39: 8551-8551. DOI: 10.1200/JCO.2021.39.15_SUPPL.8551  0.379
2021 Burks EJ, Zhang J, Sullivan TB, Shi X, Sands JM, Regis SM, McKee BJ, McKee AB, Zhang S, Liu H, Liu G, Spira A, Beane J, Lenburg ME, Rieger-Christ KM. Pathologic and gene expression comparison of CT- screen detected and routinely detected stage I/0 lung adenocarcinoma in NCCN risk-matched cohorts. Cancer Treatment and Research Communications. 29: 100486. DOI: 10.1016/j.ctarc.2021.100486  0.302
2020 Ostrin EJ, Sidransky D, Spira A, Hanash SM. Biomarkers for lung cancer screening and detection. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 33093160 DOI: 10.1158/1055-9965.EPI-20-0865  0.364
2020 Faiz A, Imkamp K, van der Wiel E, Boudewijn IM, Koppelman GH, Brandsma CA, Kerstjens HAM, Timens W, Vroegop S, Pasma HR, Boersma WG, Wielders P, van den Elshout F, Mansour K, Steiling K, ... Spira A, et al. Identifying a nasal gene expression signature associated with hyperinflation and treatment response in severe COPD. Scientific Reports. 10: 17415. PMID 33060632 DOI: 10.1038/s41598-020-72551-0  0.308
2020 Billatos E, Ash SY, Duan F, Xu K, Romanoff J, Marques H, Moses E, Han MK, Regan EA, Bowler RP, Mason SE, Doyle TJ, San José Estépar R, Rosas IO, Ross JC, ... ... Spira A, et al. Distinguishing smoking related lung disease phenotypes via imaging and molecular features. Chest. PMID 32946850 DOI: 10.1016/J.Chest.2020.08.2115  0.378
2020 Treekitkarnmongkol W, Hassane M, Sinjab A, Chang K, Hara K, Rahal Z, Zhang J, Lu W, Sivakumar S, McDowell TL, Kantrowitz J, Zhou J, Lang W, Xu L, Ochieng JK, ... ... Spira AE, et al. Augmented Lipocalin-2 is Associated with COPD and Counteracts Lung Adenocarcinoma Development. American Journal of Respiratory and Critical Care Medicine. PMID 32730093 DOI: 10.1164/Rccm.202004-1079Oc  0.416
2020 Shi X, Zhang J, Callori S, Campbell J, Fine D, Gesthalter Y, Liu G, Xiao X, Spira A, Lenburg M, Beane J. Abstract 3377: NSCLC subtype-associated molecular and cellular alterations in the normal-appearing bronchial epithelium Cancer Research. 80: 3377-3377. DOI: 10.1158/1538-7445.Am2020-3377  0.759
2020 Sinjab A, Han G, Treekitkarnmongkol W, Brennan P, Hara K, Chang K, Bogatenkova E, Sanchez-Espiridion B, Behrens C, Zhang J, Sepesi B, Cascone T, Gibbons DL, Chen J, Eapen G, ... ... Spira AE, et al. Abstract 1518: A single-cell transcriptomic atlas of lung adenocarcinoma and adjacent normal-appearing tissue Tumor Biology. DOI: 10.1158/1538-7445.Am2020-1518  0.338
2020 Merenstein C, Breda J, Mazzilli S, Burks E, Stevenson C, Reid M, Spira A, Lenburg M, Beane J. Abstract 1098: Mediators of early immune response in bronchial premalignant lesions Tumor Biology. DOI: 10.1158/1538-7445.Am2020-1098  0.582
2019 Duclos GE, Teixeira VH, Autissier P, Gesthalter YB, Reinders-Luinge MA, Terrano R, Dumas YM, Liu G, Mazzilli SA, Brandsma CA, van den Berge M, Janes SM, Timens W, Lenburg ME, Spira A, et al. Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolution. Science Advances. 5: eaaw3413. PMID 31844660 DOI: 10.1126/Sciadv.Aaw3413  0.674
2019 Garland L, Guillen-Rodriguez J, Hsu CH, Yozwiak M, Zhang HH, Alberts DS, Davis LE, Szabo E, Merenstein C, Lel J, Zhang X, Liu H, Liu G, Spira AE, Beane J, et al. Effect of intermittent versus continuous low dose aspirin on nasal epithelium gene expression in current smokers: A randomized, double-blinded trial. Cancer Prevention Research (Philadelphia, Pa.). PMID 31451521 DOI: 10.1158/1940-6207.Capr-19-0036  0.697
2019 Corbett SE, Nitzberg M, Moses E, Kleerup E, Wang T, Perdomo C, Perdomo C, Liu G, Zhang S, Liu H, Elashoff DA, Brooks DR, O'Connor GT, Dubinett SM, Spira A, et al. Gene Expression Alterations in the Bronchial Epithelium of Electronic Cigarette Users. Chest. PMID 31233743 DOI: 10.1016/J.Chest.2019.05.022  0.346
2019 Krysan K, Tran LM, Grimes BS, Fishbein GA, Seki A, Gardner BK, Walser TC, Salehi-Rad R, Yanagawa J, Lee JM, Sharma S, Aberle D, Spira AE, Elashoff DA, Wallace WD, et al. The immune contexture associates with the genomic landscape in lung adenomatous premalignancy. Cancer Research. PMID 31142513 DOI: 10.1158/0008-5472.Can-19-0153  0.351
2019 Hijazi K, Malyszko B, Steiling K, Xiao X, Liu G, Alekseyev YO, Dumas YM, Hertsgaard L, Jensen J, Hatsukami D, Brooks DR, O'Connor G, Beane J, Lenburg ME, Spira A. Tobacco-Related Alterations in Airway Gene Expression are Rapidly Reversed Within Weeks Following Smoking-Cessation. Scientific Reports. 9: 6978. PMID 31061400 DOI: 10.1038/S41598-019-43295-3  0.667
2019 Beane JE, Mazzilli SA, Campbell JD, Duclos G, Krysan K, Moy C, Perdomo C, Schaffer M, Liu G, Zhang S, Liu H, Vick J, Dhillon SS, Platero SJ, Dubinett SM, ... ... Spira AE, et al. Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions. Nature Communications. 10: 1856. PMID 31015447 DOI: 10.1038/S41467-019-09834-2  0.71
2019 Kadara H, Sivakumar S, Jakubek Y, San Lucas FA, Lang W, McDowell T, Weber Z, Behrens C, Davies GE, Kalhor N, Moran C, El-Zein R, Mehran R, Swisher SG, Wang J, ... ... Spira AE, et al. Driver Mutations in Normal Airway Epithelium Elucidate Spatiotemporal Resolution of Lung Cancer. American Journal of Respiratory and Critical Care Medicine. PMID 30896962 DOI: 10.1164/Rccm.201806-1178Oc  0.333
2019 Billatos E, Duan F, Moses E, Marques H, Mahon I, Dymond L, Apgar C, Aberle D, Washko G, Spira A. Detection of early lung cancer among military personnel (DECAMP) consortium: study protocols. Bmc Pulmonary Medicine. 19: 59. PMID 30845938 DOI: 10.1186/S12890-019-0825-7  0.352
2019 Teixeira VH, Pipinikas CP, Pennycuick A, Lee-Six H, Chandrasekharan D, Beane J, Morris TJ, Karpathakis A, Feber A, Breeze CE, Ntolios P, Hynds RE, Falzon M, Capitanio A, Carroll B, ... ... Spira A, et al. Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions. Nature Medicine. PMID 30664780 DOI: 10.1038/S41591-018-0323-0  0.703
2019 xu f, Tanabe N, Macdonough J, Vasilescu D, Ikezoe K, Kinose D, Ng K, Verleden S, Vanaudenaerde B, Verschakelen J, Cooper J, Lenburg M, Spira A, Ng R, Hogg J. The transition from normal lung anatomy to Fibrosis in IPF European Respiratory Journal. DOI: 10.1183/13993003.Congress-2019.Oa470  0.3
2019 Becker EJ, Faiz A, Berge MVd, Timens W, Hiemstra PS, Liu G, Zhang X, Alekseyev YO, O'Connor GT, Lam S, Spira A, Lenburg ME, Steiling K. A Bronchial Airway Gene Expression Signature of Future Lung Function Decline Is Enriched in XBP1-Regulated Genes American Journal of Respiratory and Critical Care Medicine. 199. DOI: 10.1164/Ajrccm-Conference.2019.199.1_Meetingabstracts.A7234  0.409
2019 Mazzilli SA, Hijazi K, Pihl R, Belkina A, Zhang X, Liu G, Lenburg M, Stevenson C, Spira A, Beane J. Abstract 660: The molecular characterization of a murine lung premalignancy model for lung cancer interception Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-660  0.701
2019 Zhang J, Burks E, Beane J, Sullivan T, Liu G, Dubinett S, Lenburg M, Spira A. Abstract 3530: Gene expression alterations associated with histologic aggressiveness in stage I lung adenocarcinomas Cancer Research. 79: 3530-3530. DOI: 10.1158/1538-7445.Sabcs18-3530  0.689
2019 Hijazi K, Lel J, Billatos E, Moses E, Stevenson CS, Lorenzi MV, Liu G, Campbell JD, Koga Y, Zhang J, Duan F, Marques H, Lenburg ME, Spira AE, Beane J. Abstract 3393: Altered immune response in the transcriptome of patients with lung cancer Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-3393  0.679
2019 Lamb C, Hospital L, Center M, Ding J, Saberi S, Pankratz D, Babiarz J, Chamberlin J, Bhorade S, Wilde J, Walsh P, Lofaro L, Huang J, Stevenson C, Lenburg M, ... ... Spira A, et al. LUNG CANCER DETECTION VIA WHOLE-TRANSCRIPTOME RNA SEQUENCING OF NASAL EPITHELIUM Chest. 156: A1091-A1092. DOI: 10.1016/J.Chest.2019.08.1005  0.366
2018 Seijo LM, Peled N, Ajona D, Boeri M, Field JK, Sozzi G, Pio R, Zulueta JJ, Spira A, Massion PP, Mazzone PJ, Montuenga LM. Biomarkers in Lung Cancer Screening: Achievements, Promises, and Challenges. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. PMID 30529598 DOI: 10.1016/J.Jtho.2018.11.023  0.327
2018 Khalil A, Dekmak B, Boulos F, Kantrowitz J, Spira A, Fujimoto J, Kadara H, El-Hachem N, Nemer G. Transcriptomic Alterations in Lung Adenocarcinoma Unveil New Mechanisms Targeted by the Subfamily of Tumor Suppressor Genes. Frontiers in Oncology. 8: 482. PMID 30425966 DOI: 10.3389/Fonc.2018.00482  0.445
2018 Billatos E, Faiz A, Gesthalter YO, LeClerc A, Alekseyev Y, Zhang X, Liu G, Ten Hacken NHT, Heijink I, Timens W, Brandsma CA, Postma DS, van den Berge M, Spira A, Lenburg ME. The Impact of Acute Exposure to Cigarette Smoke on Airway Gene Expression. Physiological Genomics. PMID 29932825 DOI: 10.1152/Physiolgenomics.00092.2017  0.301
2018 Billatos E, Vick JL, Lenburg ME, Spira AE. The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29463557 DOI: 10.1158/1078-0432.Ccr-16-3187  0.481
2018 Kantrowitz J, Sinjab A, Xu L, McDowell TL, Sivakumar S, Lang W, Nunomura-Nakamura S, Fukuoka J, Nemer G, Darwiche N, Chami H, Tfayli A, Wistuba II, Scheet P, Fujimoto J, ... Spira AE, et al. Genome-wide gene expression changes in the normal-appearing airway during the evolution of smoking-associated lung adenocarcinoma. Cancer Prevention Research (Philadelphia, Pa.). PMID 29382653 DOI: 10.1158/1940-6207.Capr-17-0295  0.518
2018 Faiz A, Billatos E, Lenburg M, Spira A, Vonk J, Boezen M, Heijink I, Berge MVD. SNPs which influence the transcriptional response to acute smoke exposure are associated with long term lung function decline in smokers European Respiratory Journal. 52. DOI: 10.1183/13993003.Congress-2018.Pa927  0.308
2018 Steiling K, Zhang J, Sands J, Sullivan T, Billatos E, Moses E, Liu G, Lamb C, McKee B, Lenburg M, Spira A, Rieger-Christ K. Abstract A15: Nasal gene expression for the diagnostic evaluation of indeterminate pulmonary nodules within a screening population Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Aacriaslc18-A15  0.483
2018 Beane JE, Mazzilli S, Tassinari A, Campbell J, Moy C, Schaffer M, Perdomo C, Jenkins D, Pine MB, Liu G, Zhang S, Lin H, Vick J, Johnson E, Platero S, ... ... Spira A, et al. Abstract A05: Bronchial premalignant lesions have distinct molecular subtypes associated with future histologic progression Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Aacriaslc18-A05  0.742
2018 Mazzilli S, Zhang S, Liu G, Lenburg M, Spira A, Beane J. Abstract B18: The carcinogen-induced NTCU model: A preclinical mouse model for lung cancer interception Cancer Research. 78. DOI: 10.1158/1538-7445.Mousemodels17-B18  0.725
2018 Sivakumar S, Jakubek Y, Lucas FAS, Lang W, McDowell C, Weber Z, Behrens C, Kalhor N, Moran C, El-Zein R, Davies G, Fujimoto J, Mehran R, Swisher SG, Wang J, ... ... Spira AE, et al. Abstract 3997: Somatic mutational processes in the cancerization field of the normal-appearing airway reveal early drivers in the development of non-small cell lung cancer Tumor Biology. DOI: 10.1158/1538-7445.Am2018-3997  0.363
2018 Shi X, Duclos G, Campbell J, Gesthalter Y, Autissier P, Dumas YM, Terrano R, Liu G, Lenburg ME, Spira A, Beane J. Abstract 2534: Single-cell RNA sequencing reveals lung cancer-associated alterations in bronchial cell subpopulations in the mainstem bronchus Cancer Research. 78: 2534-2534. DOI: 10.1158/1538-7445.Am2018-2534  0.746
2018 Shi X, Billatos E, Zhang J, Beane J, Moses E, Liu G, Stevenson C, Lenburg ME, Spira A. Abstract 2531: Diagnostic evaluation of indeterminate pulmonary nodules via rna-seq of bronchial epithelium Cancer Research. 78: 2531-2531. DOI: 10.1158/1538-7445.Am2018-2531  0.73
2018 LEE H, BHADRA K, WHITTEN P, ESTERLE M, BERNSTEIN M, DOTSON T, BENZAQUEN S, MAZZONE P, GORDON J, HOGARTH D, JOHNSON M, HUANG J, GRISCOM B, LOFARO L, KENNEDY G, ... SPIRA A, et al. CLINICAL UTILITY OF A BRONCHIAL GENOMIC CLASSIFIER FOR LUNG CANCER DETECTION: RESULTS FROM A MULTICENTER PROSPECTIVE REGISTRY Chest. 154: 597A-599A. DOI: 10.1016/J.Chest.2018.08.540  0.358
2017 Boudewijn IM, Faiz A, Steiling K, van der Wiel E, Telenga ED, Hoonhorst SJM, Ten Hacken NHT, Brandsma CA, Kerstjens HAM, Timens W, Heijink IH, Jonker MR, de Bruin HG, Sebastiaan Vroegop J, Pasma HR, ... ... Spira A, et al. Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression. Respiratory Research. 18: 213. PMID 29268739 DOI: 10.1186/S12931-017-0696-5  0.306
2017 Dubinett SM, Spira AE. Impact of COPD on Immune-based Treatment for Lung Cancer: Moving Towards Disease Interception. American Journal of Respiratory and Critical Care Medicine. PMID 29072842 DOI: 10.1164/Rccm.201710-2065Ed  0.354
2017 Khalil AA, Sivakumar S, Lucas FAS, McDowell T, Lang W, Tabata K, Fujimoto J, Yatabe Y, Spira A, Scheet P, Nemer G, Kadara H. TBX2 subfamily suppression in lung cancer pathogenesis: a high-potential marker for early detection. Oncotarget. 8: 68230-68241. PMID 28978111 DOI: 10.18632/Oncotarget.19938  0.457
2017 Tessema M, Yingling CM, Picchi MA, Wu G, Ryba T, Lin Y, Bungum AO, Edell ES, Spira A, Belinsky SA. ANK1 Methylation Regulates Expression of MicroRNA-486-5p and Discriminates Lung tumors by Histology and Smoking Status. Cancer Letters. PMID 28965852 DOI: 10.1016/J.Canlet.2017.09.038  0.337
2017 Sivakumar S, San Lucas FA, McDowell TL, Lang W, Xu L, Fujimoto J, Zhang J, Futreal PA, Fukuoka J, Yatabe Y, Dubinett SM, Spira AE, Fowler J, Hawk ET, Wistuba II, et al. Genomic landscape of atypical adenomatous hyperplasia reveals divergent modes to lung adenocarcinoma. Cancer Research. PMID 28951454 DOI: 10.1158/0008-5472.Can-17-1605  0.362
2017 Pavel AB, Campbell JD, Liu G, Elashoff DA, Dubinett SM, Smith K, Whitney D, Lenburg ME, Spira AE. Alterations in bronchial airway microRNA expression for lung cancer detection. Cancer Prevention Research (Philadelphia, Pa.). PMID 28877936 DOI: 10.1158/1940-6207.Capr-17-0098  0.44
2017 Suzuki M, Sze MA, Campbell JD, Brothers JF, Lenburg ME, McDonough JE, Elliott WM, Cooper JD, Spira A, Hogg JC. The cellular and molecular determinants of emphysematous destruction in COPD. Scientific Reports. 7: 9562. PMID 28842670 DOI: 10.1038/S41598-017-10126-2  0.358
2017 Beane J, Campbell JD, Lel J, Vick J, Spira A. Genomic approaches to accelerate cancer interception. The Lancet. Oncology. 18: e494-e502. PMID 28759388 DOI: 10.1016/S1470-2045(17)30373-X  0.624
2017 Beane J, Mazzilli SA, Tassinari AM, Liu G, Zhang X, Liu H, Dy Buncio A, Dhillon SS, Platero SJ, Lenburg ME, Reid ME, Lam S, Spira AE. Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28533227 DOI: 10.1158/1078-0432.Ccr-16-2540  0.745
2017 Vachani A, Sequist LV, Spira A. AJRCCM: 100-Year Anniversary. The Shifting Landscape for Lung Cancer: Past, Present, and Future. American Journal of Respiratory and Critical Care Medicine. 195: 1150-1160. PMID 28459327 DOI: 10.1164/Rccm.201702-0433Ci  0.385
2017 Obeidat M, Nie Y, Fishbane N, Li X, Bossé Y, Joubert P, Nickle DC, Hao K, Postma DS, Timens W, Sze MA, Shannon CP, Hollander Z, Ng RT, McManus B, ... ... Spira A, et al. Integrative Genomics of Emphysema Associated Genes Reveals Potential Disease Biomarkers. American Journal of Respiratory Cell and Molecular Biology. PMID 28459279 DOI: 10.1165/Rcmb.2016-0284Oc  0.379
2017 Boudewijn IM, Faiz A, Steiling K, Wiel Evd, Telenga E, Hoonhorst S, Hacken Nt, Brandsma C, Kerstjens H, Timens W, Heijink I, Jonker M, Bruin Hd, Vroegop S, Pasma H, ... ... Spira A, et al. A nasal gene expression profile differentiates individuals with and without COPD and overlaps bronchial gene expression European Respiratory Journal. 50. DOI: 10.1183/1393003.Congress-2017.Pa4470  0.323
2017 Beane JE, Mazzilli S, Campbell J, Moy C, Schaffer M, Perdomo C, Jenkins D, Liu G, Zhang S, Liu H, Vick J, Johnson E, Platero S, Lenburg M, Reid M, ... ... Spira A, et al. Abstract 5002: Premalignant squamous cell lung carcinoma lesions have distinct molecular subtypes associated with histologic progression Cancer Research. 77: 5002-5002. DOI: 10.1158/1538-7445.Am2017-5002  0.674
2017 Campbell J, Zhang X, Dhillon SS, Perdomo C, Mazzilli S, Geshalter Y, Liu G, Zhang S, Lin H, Vick J, Moy C, Monti S, Johnson E, Meyerson M, Dubinett S, ... ... Spira A, et al. Abstract 3259: The genomic landscape of premalignant lung squamous cell carcinoma lesions Cancer Research. 77: 3259-3259. DOI: 10.1158/1538-7445.Am2017-3259  0.666
2017 Sivakumar S, Jakubek Y, Lang W, McDowell T, Garcia MM, Chow C, Weber Z, Behrens C, Kalhor N, Moran C, El-Zein R, Davies G, Fujimoto J, Mehran R, Swisher SG, ... ... Spira AE, et al. Abstract 1434: Mutational landscape in the normal-appearing airway cancerization field of early-stage non-small cell lung cancer Cancer Research. 77: 1434-1434. DOI: 10.1158/1538-7445.Am2017-1434  0.36
2017 Duclos GE, Campbell JD, Gesthalter Y, Autissier P, Dumas YM, Terrano R, Liu G, Lenburg ME, Spira A, Beane J. Abstract 1433: Single cell RNA sequencing reveals smoking-associated alterations in bronchial airway epithelial subpopulations Cancer Research. 77: 1433-1433. DOI: 10.1158/1538-7445.Am2017-1433  0.748
2017 Mazzilli SA, Tassinari A, Xiao X, Liu G, Dhillon S, Johnson C, Reid M, Lenburg M, Spira A, Beane J. Abstract 1252: A pre-clinical model for lung cancer interception: gene expression similarities between human and mouse bronchial premalignant lesions Cancer Research. 77: 1252-1252. DOI: 10.1158/1538-7445.Am2017-1252  0.717
2017 Sivakumar S, San Lucas F, McDowell T, Lang W, Xu L, Fujimoto J, Zhang J, Wistuba I, Futreal F, Fukuoka J, Yatabe Y, Dubinett S, Spira A, Fowler J, Hawk E, et al. Genomic Landscape of Atypical Adenomatous Hyperplasia and Their Progression to Lung Adenocarcinomas Journal of Thoracic Oncology. 12: S1546. DOI: 10.1016/J.Jtho.2017.06.061  0.341
2017 Lee H, Whitten P, Bhadra K, Dotson T, Hogarth D, Benzaquen S, Pritchett M, Gordon J, Bedekar A, Esterle M, Smith K, Bianchi P, Lenburg M, Spira A. Prospective Utility of a Bronchial Genomic Classifier for Lung Cancer Detection: Interim Results From a Multicenter Prospective Registry Chest. 152: A625. DOI: 10.1016/J.Chest.2017.08.658  0.369
2016 Rahman SM, Ji X, Zimmerman LJ, Li M, Harris BK, Hoeksema MD, Trenary IA, Zou Y, Qian J, Slebos RJ, Beane J, Spira A, Shyr Y, Eisenberg R, Liebler DC, et al. The airway epithelium undergoes metabolic reprogramming in individuals at high risk for lung cancer. Jci Insight. 1: e88814. PMID 27882349 DOI: 10.1172/Jci.Insight.88814  0.681
2016 Moses E, Wang T, Corbett S, Jackson GR, Drizik E, Perdomo C, Perdomo C, Kleerup E, Brooks D, O'Connor G, Dubinett S, Hayden P, Lenburg ME, Spira A. Molecular impact of electronic cigarette aerosol exposure in human bronchial epithelium. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27701119 DOI: 10.1093/Toxsci/Kfw198  0.309
2016 Lam S, Mandrekar SJ, Gesthalter Y, Allen Ziegler KL, Seisler DK, Midthun DE, Mao JT, Aubry MC, McWilliams A, Sin DD, Shaipanich T, Liu G, Johnson E, Bild AH, Lenburg ME, ... ... Spira AE, et al. A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia. Cancer Prevention Research (Philadelphia, Pa.). PMID 27658890 DOI: 10.1158/1940-6207.Capr-15-0254  0.627
2016 Spira A, Halmos B, Powell CA. Update in Lung Cancer 2015. American Journal of Respiratory and Critical Care Medicine. 194: 661-671. PMID 27628077 DOI: 10.1164/Rccm.201604-0898Up  0.393
2016 Jakubek Y, Lang W, Vattathil S, Garcia M, Xu L, Huang L, Yoo SY, Shen L, Lu W, Chow CW, Weber Z, Davies G, Huang J, Behrens C, Kalhor N, ... Spira AE, et al. Genomic landscape established by allelic imbalance in the cancerization field of a normal appearing airway. Cancer Research. PMID 27216194 DOI: 10.1158/0008-5472.Can-15-3064  0.389
2016 Ferguson JS, Van Wert R, Choi Y, Rosenbluth MJ, Smith KP, Huang J, Spira A. Impact of a bronchial genomic classifier on clinical decision making in patients undergoing diagnostic evaluation for lung cancer. Bmc Pulmonary Medicine. 16: 66. PMID 27184093 DOI: 10.1186/S12890-016-0217-1  0.382
2016 Kusko RL, Brothers Ii JF, Tedrow J, Pandit K, Huleihel L, Perdomo C, Liu G, Juan-Guardela B, Kass D, Zhang S, Lenburg M, Martinez F, Quackenbush J, Sciurba F, Limper A, ... ... Spira A, et al. Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying COPD and IPF. American Journal of Respiratory and Critical Care Medicine. PMID 27104832 DOI: 10.1164/Rccm.201510-2026Oc  0.584
2016 Kadara H, Scheet P, Wistuba II, Spira AE. Early events in the molecular pathogenesis of lung cancer. Cancer Prevention Research (Philadelphia, Pa.). PMID 27006378 DOI: 10.1158/1940-6207.Capr-15-0400  0.442
2016 Vachani A, Whitney DH, Parsons EC, Lenburg M, Ferguson JS, Silvestri GA, Spira A. Clinical Utility of a Bronchial Genomic Classifier in Patients with Suspected Lung Cancer. Chest. PMID 26896702 DOI: 10.1016/J.Chest.2016.02.636  0.408
2016 Campbell JD, Mazzilli SA, Reid ME, Dhillon SS, Platero S, Beane J, Spira AE. The Case for a Pre-Cancer Genome Atlas (PCGA). Cancer Prevention Research (Philadelphia, Pa.). 9: 119-24. PMID 26839336 DOI: 10.1158/1940-6207.Capr-16-0024  0.659
2016 Grimes BS, Krysan K, Tran LM, Park SJ, Aberle DR, Spira AE, Dubinett SM. Indolence versus aggression in non-small cell lung cancer: defining heterogeneity to impact clinical outcomes Translational Cancer Research. 5. DOI: 10.21037/11283  0.348
2016 Mazzilli SA, Tassinari A, Gethalter Y, Lui G, Pine M, Lam S, Reid M, Platero S, Lenburg M, Spira A, Beane J. Abstract 896: The airway field of injury reflects gene expression changes associated with the presence of lung squamous premalignant lesions Cancer Research. 76: 896-896. DOI: 10.1158/1538-7445.Am2016-896  0.694
2016 Campbell JD, Perdomo C, Mazzilli S, Geshalter Y, Dhillon SS, Liu G, Zhang S, Lin H, Vick J, Moy C, Johnson E, Meyerson M, Platero S, Lenburg M, Reid M, ... Spira A, et al. Abstract 895: Genomic characterization of premalignant lung squamous cell carcinoma lesions Cancer Research. 76: 895-895. DOI: 10.1158/1538-7445.Am2016-895  0.734
2016 Moses E, Wang T, Jackson GR, Corbett S, Drizik E, Brooks D, O’Connor G, Perdomo C, Dubinett S, Hayden P, Lenburg ME, Spira A. Abstract 4502: Molecular impact of in vitro exposure to electronic cigarette vapor in human bronchial epithelium Cancer Research. 76: 4502-4502. DOI: 10.1158/1538-7445.Am2016-4502  0.304
2016 Pavel AB, Campbell J, Liu G, Zhang S, Liu H, Xiao J, Porta K, Whitney D, Dubinett S, Elashoff D, Lenburg M, Spira A. Abstract 1954: microRNA expression in bronchial epithelium for lung cancer detection Cancer Research. 76: 1954-1954. DOI: 10.1158/1538-7445.Am2016-1954  0.379
2016 Mascaux C, Angelova M, Beane J, Hijazi K, Antoine G, Gallo KW, Ninane V, Burny A, Sculier J, Spira A, Galon J. Abstract 1419: Characterization of the evolution of immune response in lung squamous carcinogenesis Cancer Research. 76: 1419-1419. DOI: 10.1158/1538-7445.Am2016-1419  0.704
2016 Van Wert R, Ferguson J, Choi Y, Rosenbluth M, Spira A. Impact of a Bronchial Genomic Classifier for Lung Cancer on Reducing Invasive Procedure Recommendations Across Variations in Pulmonology Practices Chest. 150: 732A. DOI: 10.1016/j.chest.2016.08.827  0.329
2016 Becker E, Lam S, van den Berge M, Liu G, Zhang X, Alekseyev Y, Spira A, Lenburg M, Steiling K. Predicting Lung Function Decline in COPD Using Bronchial Airway Gene Expression Chest. 150: 912A. DOI: 10.1016/J.Chest.2016.08.1012  0.4
2015 Ou SI, Ahn JS, De Petris L, Govindan R, Yang JC, Hughes B, Lena H, Moro-Sibilot D, Bearz A, Ramirez SV, Mekhail T, Spira A, Bordogna W, Balas B, Morcos PN, et al. Alectinib in Crizotinib-Refractory ALK-Rearranged Non-Small-Cell Lung Cancer: A Phase II Global Study. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. PMID 26598747 DOI: 10.1200/JCO.2015.63.9443  0.317
2015 Wang TW, Vermeulen RC, Hu W, Liu G, Xiao X, Alekseyev Y, Xu J, Reiss B, Steiling K, Downward GS, Silverman DT, Wei F, Wu G, Li J, Lenburg ME, ... ... Spira A, et al. Gene-expression profiling of buccal epithelium among nonsmoking women exposed to household air pollution from smoky coal. Carcinogenesis. PMID 26468118 DOI: 10.1093/Carcin/Bgv150  0.381
2015 Spira A, Halmos B, Powell CA. Update in Lung Cancer 2014. American Journal of Respiratory and Critical Care Medicine. 192: 283-94. PMID 26230235 DOI: 10.1164/Rccm.201504-0756Up  0.4
2015 Silvestri GA, Vachani A, Whitney D, Elashoff M, Porta Smith K, Ferguson JS, Parsons E, Mitra N, Brody J, Lenburg ME, Spira A. A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer. The New England Journal of Medicine. 373: 243-51. PMID 25981554 DOI: 10.1056/Nejmoa1504601  0.439
2015 Sze MA, Dimitriu PA, Suzuki M, McDonough JE, Campbell JD, Brothers JF, Erb-Downward JR, Huffnagle GB, Hayashi S, Elliott WM, Cooper J, Sin DD, Lenburg ME, Spira A, Mohn WW, et al. The Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. PMID 25945594 DOI: 10.1164/Rccm.201502-0223Oc  0.338
2015 Whitney DH, Elashoff MR, Porta-Smith K, Gower AC, Vachani A, Ferguson JS, Silvestri GA, Brody JS, Lenburg ME, Spira A. Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy. Bmc Medical Genomics. 8: 18. PMID 25944280 DOI: 10.1186/S12920-015-0091-3  0.487
2015 Gesthalter YB, Vick J, Steiling K, Spira A. Translating the transcriptome into tools for the early detection and prevention of lung cancer. Thorax. 70: 476-81. PMID 25628310 DOI: 10.1136/Thoraxjnl-2014-206605  0.379
2015 Yoo S, Takikawa S, Geraghty P, Argmann C, Campbell J, Lin L, Huang T, Tu Z, Foronjy RF, Feronjy R, Spira A, Schadt EE, Powell CA, Zhu J. Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. Plos Genetics. 11: e1004898. PMID 25569234 DOI: 10.1371/Journal.Pgen.1004898  0.376
2015 Campbell JD, Liu G, Luo L, Xiao J, Gerrein J, Juan-Guardela B, Tedrow J, Alekseyev YO, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba F, Schwartz DA, Kaminski N, ... ... Spira A, et al. Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data. Rna (New York, N.Y.). 21: 164-71. PMID 25519487 DOI: 10.1261/Rna.046060.114  0.606
2015 Billatos E, Gesthalter Y, ten Hacken N, Postma D, Heijink I, Timens W, Brandsma C, Faiz A, Berge M, Lenburg M, Spira A. The Impact of Acute Smoking on Airway Gene-Expression Chest. 148: 746A. DOI: 10.1378/Chest.2280491  0.328
2015 Vachani A, Silvestri G, Whitney D, Ferguson J, Porta K, Parsons E, Brody J, Lenburg M, Spira A. Prospective Validation of a Bronchial Genomic Classifier for Lung Cancer in Patients Undergoing Diagnostic Bronchoscopy: The AEGIS Trials Chest. 148: 544A. DOI: 10.1378/Chest.2280365  0.348
2015 Spira A, Halmos B, Powell CA. Update in lung cancer 2014 American Journal of Respiratory and Critical Care Medicine. 192: 283-294. DOI: 10.1164/rccm.201504-0756UP  0.393
2015 Mazzilli SA, Liu G, Zhang X, Si H, Lam S, Lenburg M, Spira A, Beane JE. Abstract A11: Airway gene expression indicates an increase in oxidative phosphorylation in the field of injury of individuals with premalignant lesions Cancer Prevention Research. 8. DOI: 10.1158/1940-6215.Prev-14-A11  0.712
2015 Perez-Rogers JF, Gerrein J, Anderlind C, Kusko RL, Campbell JD, Wang TW, Porta K, Whitney D, Spira A, Lenburg M. Abstract A1-66: Leveraging Gene Expression in the Bronchial Airway to Develop a Nasal Biomarker for Early Detection of Lung Cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-A1-66  0.501
2015 Tassinari A, Zhang B, Steiling K, Whitney D, Porta K, Lam S, Lenburg M, Spira A, Beane J. Abstract B1-17: Airway gene-coexpression network rewiring in the presence of bronchial dysplasia and lung cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Compsysbio-B1-17  0.699
2015 Pavel AB, Campbell JD, Liu G, Zhang S, Liu H, Luo L, Xiao J, Porta K, Whitney D, Dubinett S, Elashoff D, Lenburg ME, Spira A. Abstract 3077: Dysregulation of microRNA-mRNA regulatory networks in the bronchial airway epithelium of smokers with lung cancer Cancer Research. 75: 3077-3077. DOI: 10.1158/1538-7445.Am2015-3077  0.486
2015 Beane JE, Campbell J, Moy C, Perdomo C, Schaffer M, Mazzilli S, Geshalter Y, Kantrowitz J, Zhang L, Jenkins D, Pine MB, Dhillon S, Liu G, Liu H, Zhang S, ... ... Spira A, et al. Abstract 2878: Development of the pre-cancer genome atlas (PCGA) for squamous cell lung carcinoma Cancer Research. 75: 2878-2878. DOI: 10.1158/1538-7445.Am2015-2878  0.746
2015 Perez-Rogers J, Gerrein J, Anderlind C, Xiao X, Liu H, Kusko R, Campbell J, Wang T, Alekseyev Y, Liu G, Porta K, Whitney D, Spira A, Lenburg M. Abstract 1574: Leveraging bronchial airway gene expression to develop a nasal biomarker for lung cancer detection Cancer Research. 75: 1574-1574. DOI: 10.1158/1538-7445.Am2015-1574  0.496
2014 Yang IV, Pedersen BS, Rabinovich E, Hennessy CE, Davidson EJ, Murphy E, Guardela BJ, Tedrow JR, Zhang Y, Singh MK, Correll M, Schwarz MI, Geraci M, Sciurba FC, Quackenbush J, ... Spira A, et al. Relationship of DNA methylation and gene expression in idiopathic pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine. 190: 1263-72. PMID 25333685 DOI: 10.1164/Rccm.201408-1452Oc  0.322
2014 Lamontagne M, Timens W, Hao K, Bossé Y, Laviolette M, Steiling K, Campbell JD, Couture C, Conti M, Sherwood K, Hogg JC, Brandsma CA, van den Berge M, Sandford A, Lam S, ... ... Spira A, et al. Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction. Thorax. 69: 997-1004. PMID 25182044 DOI: 10.1136/Thoraxjnl-2014-205630  0.401
2014 Wang X, Pittman GS, Bandele OJ, Bischof JJ, Liu G, Brothers JF, Spira A, Bell DA. Linking polymorphic p53 response elements with gene expression in airway epithelial cells of smokers and cancer risk. Human Genetics. 133: 1467-76. PMID 25179167 DOI: 10.1007/S00439-014-1483-8  0.389
2014 Kathuria H, Gesthalter Y, Spira A, Brody JS, Steiling K. Updates and controversies in the rapidly evolving field of lung cancer screening, early detection, and chemoprevention. Cancers. 6: 1157-79. PMID 24840047 DOI: 10.3390/Cancers6021157  0.425
2014 Mok TS, Geater SL, Iannotti N, Thongprasert S, Spira A, Smith D, Lee V, Lim WT, Reyderman L, Wang B, Gopalakrishna P, Garzon F, Xu L, Reynolds C. Randomized phase II study of two intercalated combinations of eribulin mesylate and erlotinib in patients with previously treated advanced non-small-cell lung cancer. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. 25: 1578-84. PMID 24827127 DOI: 10.1093/Annonc/Mdu174  0.322
2014 Dijkstra AE, Smolonska J, van den Berge M, Wijmenga C, Zanen P, Luinge MA, Platteel M, Lammers JW, Dahlback M, Tosh K, Hiemstra PS, Sterk PJ, Spira A, Vestbo J, Nordestgaard BG, et al. Susceptibility to chronic mucus hypersecretion, a genome wide association study. Plos One. 9: e91621. PMID 24714607 DOI: 10.1371/Journal.Pone.0091621  0.31
2014 Ooi AT, Gower AC, Zhang KX, Vick JL, Hong L, Nagao B, Wallace WD, Elashoff DA, Walser TC, Dubinett SM, Pellegrini M, Lenburg ME, Spira A, Gomperts BN. Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis. Cancer Prevention Research (Philadelphia, Pa.). 7: 487-95. PMID 24618292 DOI: 10.1158/1940-6207.Capr-13-0372  0.426
2014 Christmann RB, Sampaio-Barros P, Stifano G, Borges CL, de Carvalho CR, Kairalla R, Parra ER, Spira A, Simms R, Capellozzi VL, Lafyatis R. Association of Interferon- and transforming growth factor β-regulated genes and macrophage activation with systemic sclerosis-related progressive lung fibrosis. Arthritis & Rheumatology (Hoboken, N.J.). 66: 714-25. PMID 24574232 DOI: 10.1002/Art.38288  0.39
2014 Kadara H, Fujimoto J, Yoo SY, Maki Y, Gower AC, Kabbout M, Garcia MM, Chow CW, Chu Z, Mendoza G, Shen L, Kalhor N, Hong WK, Moran C, Wang J, ... Spira A, et al. Transcriptomic architecture of the adjacent airway field cancerization in non-small cell lung cancer. Journal of the National Cancer Institute. 106: dju004. PMID 24563515 DOI: 10.1093/Jnci/Dju004  0.42
2014 Butts C, Socinski MA, Mitchell PL, Thatcher N, Havel L, Krzakowski M, Nawrocki S, Ciuleanu TE, Bosquée L, Trigo JM, Spira A, Tremblay L, Nyman J, Ramlau R, Wickart-Johansson G, et al. Tecemotide (L-BLP25) versus placebo after chemoradiotherapy for stage III non-small-cell lung cancer (START): a randomised, double-blind, phase 3 trial. The Lancet. Oncology. 15: 59-68. PMID 24331154 DOI: 10.1016/S1470-2045(13)70510-2  0.36
2014 Vucic EA, Chari R, Thu KL, Wilson IM, Cotton AM, Kennett JY, Zhang M, Lonergan KM, Steiling K, Brown CJ, McWilliams A, Ohtani K, Lenburg ME, Sin DD, Spira A, et al. DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways. American Journal of Respiratory Cell and Molecular Biology. 50: 912-22. PMID 24298892 DOI: 10.1165/Rcmb.2013-0304Oc  0.324
2014 van den Berge M, Steiling K, Timens W, Hiemstra PS, Sterk PJ, Heijink IH, Liu G, Alekseyev YO, Lenburg ME, Spira A, Postma DS. Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity. Thorax. 69: 14-23. PMID 23925644 DOI: 10.1136/Thoraxjnl-2012-202878  0.301
2014 Jiwani A, Maple E, Schnall M, Mahon I, Apgar C, Browning R, More K, Morris M, Parrish J, Atwood C, Battaile J, Garshick E, Gatsonis C, Goldstein R, Kieth R, ... ... Spira A, et al. Detection and Validation of Molecular Biomarkers for the Early Detection of Lung Cancer Among Military and Veteran Populations: The DECAMP Consortium Chest. 146: 590A. DOI: 10.1378/Chest.1993874  0.308
2014 Park SJ, Walser TC, Perdomo C, Wang T, Hong L, Pagano PC, Liclican EL, Krysan K, Larsen JE, Fishbein MC, Minna JD, Lenburg ME, Spira A, Dubinett SM. Abstract 932: The impact of e-cigarette exposure on pulmonary epithelium gene expression and transformation Cancer Research. 74: 932-932. DOI: 10.1158/1538-7445.Am2014-932  0.442
2014 Kusko R, Garrison C, Wang T, Campbell J, Perez-Rogers J, Luo L, Beane J, Liu G, Kadara H, Belinsky S, Lenburg ME, Spira A. Abstract 3554: Gene and miRNA expression networks specific to never smoker lung adenocarcinoma Cancer Research. 74: 3554-3554. DOI: 10.1158/1538-7445.Am2014-3554  0.705
2014 Hijazi K, Bomalysz B, Steiling K, Xiao J, Liu G, Alekseyev Y, Yves MD, Hertsgaard LA, Jensen J, Vogel RI, Hatsukami D, O'Connor G, Brooks DR, Beane J, Spira A. Abstract 2354: Nasal gene expression reflects the physiologic response to potentially reduced exposure products Cancer Research. 74: 2354-2354. DOI: 10.1158/1538-7445.Am2014-2354  0.673
2014 Kusko R, Anderlind C, Wang G, Zhang S, Wallace WD, Wasler T, Ebright M, Garcia MM, Eisenberg R, Lee G, Liu G, Elashoff D, Kalhor N, Moran C, Mehran R, ... ... Spira A, et al. Abstract 2352: Mapping the airway-wide molecular field of injury in smokers with lung cancer Cancer Research. 74: 2352-2352. DOI: 10.1158/1538-7445.Am2014-2352  0.52
2014 Maki Y, Fujimoto J, Yoo S, Garcia M, Gower A, Shen L, Chow C, Behrens C, Kalhor N, Moran C, Wang J, Spira A, Coombes KR, Wistuba II, Kadara H. Abstract 1597: Transcriptomic architecture of the field of cancerization in the adjacent normal-appearing airway: Early mechanisms in lung carcinogenesis Cancer Research. 74: 1597-1597. DOI: 10.1158/1538-7445.Am2014-1597  0.454
2014 Pavel A, Campbell J, Liu G, Zhang S, Liu H, Dubinett S, Elashoff D, Porta K, Whitney D, Lenburg M, Spira A. Abstract 1485: Biomarker development for lung cancer diagnosis using integrative microRNA and gene expression networks Cancer Research. 74: 1485-1485. DOI: 10.1158/1538-7445.Am2014-1485  0.357
2014 Tassinari A, Whitney D, Porta K, Lenburg M, Spira A, Beane J. Abstract 1414: Race-associated variation in the airway transcriptome response to cigarette smoke Cancer Research. 74: 1414-1414. DOI: 10.1158/1538-7445.Am2014-1414  0.723
2013 Christenson SA, Brandsma CA, Campbell JD, Knight DA, Pechkovsky DV, Hogg JC, Timens W, Postma DS, Lenburg M, Spira A. miR-638 regulates gene expression networks associated with emphysematous lung destruction. Genome Medicine. 5: 114. PMID 24380442 DOI: 10.1186/Gm519  0.357
2013 Steiling K, Lenburg ME, Spira A. Personalized management of chronic obstructive pulmonary disease via transcriptomic profiling of the airway and lung. Annals of the American Thoracic Society. 10: S190-6. PMID 24313772 DOI: 10.1513/Annalsats.201306-190Aw  0.316
2013 Perdomo C, Campbell JD, Gerrein J, Tellez CS, Garrison CB, Walser TC, Drizik E, Si H, Gower AC, Vick J, Anderlind C, Jackson GR, Mankus C, Schembri F, O'Hara C, ... ... Spira A, et al. MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 18946-51. PMID 24158479 DOI: 10.1073/Pnas.1220319110  0.431
2013 Dubinett SM, Spira A. Challenge and opportunity of targeted lung cancer chemoprevention. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 4169-71. PMID 24002497 DOI: 10.1200/Jco.2013.51.2400  0.417
2013 Brothers JF, Hijazi K, Mascaux C, El-Zein RA, Spitz MR, Spira A. Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era. Bmc Medicine. 11: 168. PMID 23870182 DOI: 10.1186/1741-7015-11-168  0.387
2013 Zhang X, Lenburg ME, Spira A. Comparison of nasal epithelial smoking-induced gene expression on Affymetrix Exon 1.0 and Gene 1.0 ST arrays. Thescientificworldjournal. 2013: 951416. PMID 23476154 DOI: 10.1155/2013/951416  0.336
2013 Steiling K, van den Berge M, Hijazi K, Florido R, Campbell J, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, Si H, Perdomo C, Dumont C, Coxson HO, Alekseyev YO, ... ... Spira A, et al. A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. American Journal of Respiratory and Critical Care Medicine. 187: 933-42. PMID 23471465 DOI: 10.1164/Rccm.201208-1449Oc  0.363
2013 Jean JC, George E, Kaestner KH, Brown LA, Spira A, Joyce-Brady M. Transcription factor Klf4, induced in the lung by oxygen at birth, regulates perinatal fibroblast and myofibroblast differentiation. Plos One. 8: e54806. PMID 23372771 DOI: 10.1371/Journal.Pone.0054806  0.361
2013 Gomperts BN, Walser TC, Spira A, Dubinett SM. Enriching the molecular definition of the airway "field of cancerization:" establishing new paradigms for the patient at risk for lung cancer. Cancer Prevention Research (Philadelphia, Pa.). 6: 4-7. PMID 23233734 DOI: 10.1158/1940-6207.Capr-12-0470  0.435
2013 Park SJ, Walser TC, Perdomo C, Pagano PP, Brass D, Liclican EL, Krysan K, Lenburg ME, Spira A, Dubinett SM. Abstract C58: The gene expression and functional impact of E-cigarette exposure on pulmonary epithelial transformation Cancer Prevention Research. 6. DOI: 10.1158/1940-6215.Prev-13-C58  0.339
2013 Maki Y, Fujimoto J, Yoo S, Gower A, Shen L, Garcia MM, Kabbout M, Chow C, Hong WK, Kalhor N, Wang J, Moran C, Spira A, Coombes KR, Wistuba II, et al. Abstract 2367: Transcriptomic architecture of the airway field cancerization in early-stage non-small cell lung cancer . Cancer Research. 73: 2367-2367. DOI: 10.1158/1538-7445.Am2013-2367  0.482
2013 Wang T, Campbell J, Kusko R, Luo L, Tellez C, Liu G, Xiao J, Lenburg M, Belinsky S, Spira A. Abstract 1948: Shared and distinct microRNA-expression alterations in lung adenocarcinoma from smokers vs. nonsmokers. Cancer Research. 73: 1948-1948. DOI: 10.1158/1538-7445.Am2013-1948  0.373
2013 Wang TW, Lan Q, Krystyna B, Rothman N, Florido R, Hu W, Steiling K, Liu G, Xiao J, Alekseyev Y, Xu J, Wei F, Hosgood HD, Reiss B, Downward G, ... ... Spira A, et al. Abstract 112: Transcriptomic changes in the oral mucosal epithelium reflect the physiologic response to indoor burning of solid fuels. Cancer Research. 73: 112-112. DOI: 10.1158/1538-7445.Am2013-112  0.406
2013 Ooi AT, Gower A, Zhang K, Vick J, Hong L, Fishbein M, Nagao B, Wallace WD, Elashoff D, Lenburg M, Dubinett S, Spira A, Gomperts B. Abstract 1063: Examining early events in carcinogenesis by profiling premalignant lesions in the airways of patients with lung squamous cell carcinomas. Cancer Research. 73: 1063-1063. DOI: 10.1158/1538-7445.Am2013-1063  0.491
2013 Grayson P, Steiling K, Monach P, Platt M, Xiao J, Zhang X, Alekseyev Y, Moni S, Spira A, Merkel P. Upper airway gene expression profiling in granulomatosis with polyangiitis Presse Medicale. 42: 660-661. DOI: 10.1016/J.Lpm.2013.02.025  0.303
2012 Beane J, Cheng L, Soldi R, Zhang X, Liu G, Anderlind C, Lenburg ME, Spira A, Bild AH. SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue. Cancer Research. 72: 5702-11. PMID 22986747 DOI: 10.1158/0008-5472.Can-12-1043  0.737
2012 Campbell JD, McDonough JE, Zeskind JE, Hackett TL, Pechkovsky DV, Brandsma CA, Suzuki M, Gosselink JV, Liu G, Alekseyev YO, Xiao J, Zhang X, Hayashi S, Cooper JD, Timens W, ... ... Spira A, et al. A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK. Genome Medicine. 4: 67. PMID 22937864 DOI: 10.1186/Gm367  0.365
2012 Tagne JB, Gupta S, Gower AC, Shen SS, Varma S, Lakshminarayanan M, Cao Y, Spira A, Volkert TL, Ramirez MI. Genome-wide analyses of Nkx2-1 binding to transcriptional target genes uncover novel regulatory patterns conserved in lung development and tumors. Plos One. 7: e29907. PMID 22242187 DOI: 10.1371/Journal.Pone.0029907  0.395
2012 Whitney D, Luo J, Porta K, Lenburg M, Brody J, Ernst A, Vachani A, Ferguson J, Silvestri G, Spira A. Bronchial Airway Gene-Expression Testing Improves the Diagnostic Yield of Bronchoscopy for Lung Cancer: Results of the AEGIS Trial Chest. 142: 1025A. DOI: 10.1378/Chest.1450411  0.43
2012 Campbell JD, Luo L, Liu G, Xiao J, Gerrein J, Guardela BJ, Tedrow J, Aleksyev YO, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba F, Schwartz DA, Kaminski N, ... ... Spira A, et al. Characterizing the small RNA transcriptome associated with COPD and ILD using next-generation sequencing Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S6-P6  0.667
2012 Brothers J, Kusko R, Liu G, Luo L, Guardela BJ, Tedrow J, Alekesyev Y, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba F, Sebastiani P, Lenburg M, Kaminski N, ... ... Spira A, et al. Moving beyond gene expression: identification of lung-disease-associated novel transcripts and alternative splicing by RNA sequencing Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S6-P4  0.687
2012 Wang TW, Campbell JD, Luo L, Liu G, Xiao J, Lenburg ME, Belinsky SA, Spira A. Deep sequencing of the microRNA transcriptome in current, former, and never smokers with lung adenocarcinoma Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S6-P38  0.422
2012 Kusko RL, Brothers J, Liu G, Luo L, Guardela BJ, Tedrow J, Aleksyev Y, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba F, Lenburg M, Schwartz DA, Beane J, ... ... Spira A, et al. Comprehensive genomic profiling of the lung transcriptome in emphysema and idiopathic pulmonary fibrosis using RNA-Seq Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S6-P21  0.694
2012 Hijazi K, Malyszko B, Zhang X, Liu G, Alekseyev Y, Dumas Y, Hertsgaard L, Jenson J, Rohde C, Hatsukami DK, Hecht SS, Brooks DR, O'Connor G, Lenburg M, Steiling K, ... Spira A, et al. Abstract B07: Nasal epithelial gene expression profiles reflect dynamic biological response to smoking cessation Cancer Prevention Research. 5: B07-B07. DOI: 10.1158/1940-6207.Prev-12-B07  0.356
2012 Perdomo C, Campbell J, Gerrein J, Tellez C, Gower A, Vick J, Garrison C, Anderlind C, Jackson GR, Schembri F, Gomperts BN, Hayden P, Belinsky SA, Lenburg ME, Spira A. Abstract 3173: Identification of miR-4423 as a primate-specific microRNA highly expressed in airway epithelium and associated with lung cancer Cancer Research. 72: 3173-3173. DOI: 10.1158/1538-7445.Am2012-3173  0.463
2012 Campbell JD, Luo L, Xiao J, Liu G, Aleksyev Y, Elashoff D, Dubinett SM, Lenburg ME, Spira A. Abstract 3154: Sequencing of the small RNA transcriptome in cytologically normal bronchial airway epithelium of smokers with and without lung cancer Cancer Research. 72: 3154-3154. DOI: 10.1158/1538-7445.Am2012-3154  0.52
2012 Beane JE, Hijazi K, Liu G, Zhang X, Xiao J, Lam S, Lenburg M, Spira A. Abstract 1607: Airway gene expression alterations associated with lung cancer chemoprevention using green tea extract Cancer Research. 72: 1607-1607. DOI: 10.1158/1538-7445.Am2012-1607  0.725
2011 Beane J, Vick J, Schembri F, Anderlind C, Gower A, Campbell J, Luo L, Zhang XH, Xiao J, Alekseyev YO, Wang S, Levy S, Massion PP, Lenburg M, Spira A. Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq. Cancer Prevention Research (Philadelphia, Pa.). 4: 803-17. PMID 21636547 DOI: 10.1158/1940-6207.Capr-11-0212  0.738
2011 Gower AC, Steiling K, Brothers JF, Lenburg ME, Spira A. Transcriptomic studies of the airway field of injury associated with smoking-related lung disease. Proceedings of the American Thoracic Society. 8: 173-9. PMID 21543797 DOI: 10.1513/pats.201011-066MS  0.426
2011 Gomperts BN, Spira A, Massion PP, Walser TC, Wistuba II, Minna JD, Dubinett SM. Evolving concepts in lung carcinogenesis. Seminars in Respiratory and Critical Care Medicine. 32: 32-43. PMID 21500122 DOI: 10.1055/S-0031-1272867  0.426
2011 Campbell JD, Spira A, Lenburg ME. Applying gene expression microarrays to pulmonary disease. Respirology (Carlton, Vic.). 16: 407-18. PMID 21299687 DOI: 10.1111/J.1440-1843.2011.01942.X  0.304
2011 Boelens MC, Gustafson AM, Postma DS, Kok K, van der Vries G, van der Vlies P, Spira A, Lenburg ME, Geerlings M, Sietsma H, Timens W, van den Berg A, Groen HJ. A chronic obstructive pulmonary disease related signature in squamous cell lung cancer. Lung Cancer (Amsterdam, Netherlands). 72: 177-83. PMID 20832896 DOI: 10.1016/J.Lungcan.2010.08.014  0.327
2011 Gerrein J, Perdomo C, Campbell JD, Vick J, Gower A, Anderlind C, Schembri F, Lenburg M, Spira A. Abstract 3989: Discovery of a novel airway microRNA associated with lung cancer using next generation sequencing Cellular and Molecular Biology. 71: 3989-3989. DOI: 10.1158/1538-7445.Am2011-3989  0.406
2010 Ooi AT, Mah V, Nickerson DW, Gilbert JL, Ha VL, Hegab AE, Horvath S, Alavi M, Maresh EL, Chia D, Gower AC, Lenburg ME, Spira A, Solis LM, Wistuba II, et al. Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer. Cancer Research. 70: 6639-48. PMID 20710044 DOI: 10.1158/0008-5472.Can-10-0455  0.416
2010 Wang X, Chorley BN, Pittman GS, Kleeberger SR, Brothers J, Liu G, Spira A, Bell DA. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. Plos One. 5: e11934. PMID 20689807 DOI: 10.1371/Journal.Pone.0011934  0.513
2010 Gustafson AM, Soldi R, Anderlind C, Scholand MB, Qian J, Zhang X, Cooper K, Walker D, McWilliams A, Liu G, Szabo E, Brody J, Massion PP, Lenburg ME, Lam S, ... ... Spira A, et al. Airway PI3K pathway activation is an early and reversible event in lung cancer development. Science Translational Medicine. 2: 26ra25. PMID 20375364 DOI: 10.1126/Scitranslmed.3000251  0.459
2010 Gomperts BN, Spira A, Elashoff DE, Dubinett SM. Lung cancer biomarkers: FISHing in the sputum for risk assessment and early detection. Cancer Prevention Research (Philadelphia, Pa.). 3: 420-3. PMID 20332300 DOI: 10.1158/1940-6207.Capr-10-0052  0.314
2010 Spira A. Upper airway gene expression in smokers: the mouth as a "window to the soul" of lung carcinogenesis? Cancer Prevention Research (Philadelphia, Pa.). 3: 255-8. PMID 20179303 DOI: 10.1158/1940-6207.Capr-10-0013  0.437
2010 Zhang X, Sebastiani P, Liu G, Schembri F, Zhang X, Dumas YM, Langer EM, Alekseyev Y, O'Connor GT, Brooks DR, Lenburg ME, Spira A. Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium. Physiological Genomics. 41: 1-8. PMID 19952278 DOI: 10.1152/Physiolgenomics.00167.2009  0.381
2010 Hazra S, Gardner BK, Krysan K, Walser TC, Larsen JE, Pertsemlidis A, Shay JW, Minna JD, Spira A, Dubinett SM. Abstract A31: The role of microRNA 125a‐3P in the pathogenesis of lung cancer Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-A31  0.425
2010 Ooi AT, Mah VH, Nickerson DW, Gilbert JL, Ha VL, Hegab AE, Horvath S, Alavi M, Maresh E, Chia D, Gower AC, Lenburg ME, Spira A, Walser T, Wallace WD, et al. Abstract 4299: Poor prognosis in smokers with non-small cell lung cancer correlates with the presence of a reparative progenitor cell population Cancer Research. 70: 4299-4299. DOI: 10.1158/1538-7445.Am10-4299  0.378
2010 Beane J, Gerrein J, Vick J, Gindin Y, Anderlind C, Levy S, Massion P, Schembri F, Lenburg M, Spira A. Abstract 1987: RNA-seq of the bronchial airway transcriptome identifies novel gene and microRNA expression changes associated with smoking and lung cancer Cancer Research. 70: 1987-1987. DOI: 10.1158/1538-7445.Am10-1987  0.736
2010 Kathuria H, Spira A, Brody J. Genomics in the Diagnosis and Management of Lung Cancer Essentials of Genomic and Personalized Medicine. 432-445. DOI: 10.1016/B978-0-12-374934-5.00034-9  0.471
2009 Steiling K, Lenburg ME, Spira A. Airway gene expression in chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society. 6: 697-700. PMID 20008878 DOI: 10.1513/pats.200907-076DP  0.334
2009 Steiling K, Kadar AY, Bergerat A, Flanigon J, Sridhar S, Shah V, Ahmad QR, Brody JS, Lenburg ME, Steffen M, Spira A. Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokers. Plos One. 4: e5043. PMID 19357784 DOI: 10.1371/Journal.Pone.0005043  0.352
2009 Beane J, Spira A, Lenburg ME. Clinical impact of high-throughput gene expression studies in lung cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 4: 109-18. PMID 19096318 DOI: 10.1097/Jto.0B013E31819151F8  0.711
2009 Kathuria H, Spira A, Brody J. Genomics of Lung Cancer Genomic and Personalized Medicine, Two-Vol Set. 856-868. DOI: 10.1016/B978-0-12-369420-1.00071-8  0.374
2008 Steiling K, Ryan J, Brody JS, Spira A. The field of tissue injury in the lung and airway. Cancer Prevention Research (Philadelphia, Pa.). 1: 396-403. PMID 19138985 DOI: 10.1158/1940-6207.Capr-08-0174  0.423
2008 Beane J, Sebastiani P, Whitfield TH, Steiling K, Dumas YM, Lenburg ME, Spira A. A prediction model for lung cancer diagnosis that integrates genomic and clinical features. Cancer Prevention Research (Philadelphia, Pa.). 1: 56-64. PMID 19138936 DOI: 10.1158/1940-6207.Capr-08-0011  0.712
2008 Zeskind JE, Lenburg ME, Spira A. Translating the COPD transcriptome: insights into pathogenesis and tools for clinical management. Proceedings of the American Thoracic Society. 5: 834-41. PMID 19017738 DOI: 10.1513/pats.200807-074TH  0.436
2008 Sridhar S, Schembri F, Zeskind J, Shah V, Gustafson AM, Steiling K, Liu G, Dumas YM, Zhang X, Brody JS, Lenburg ME, Spira A. Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium. Bmc Genomics. 9: 259. PMID 18513428 DOI: 10.1186/1471-2164-9-259  0.412
2008 Millien G, Beane J, Lenburg M, Tsao PN, Lu J, Spira A, Ramirez MI. Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction. Gene Expression Patterns : Gep. 8: 124-39. PMID 18023262 DOI: 10.1016/J.Modgep.2007.09.003  0.71
2007 Zhang X, Liu G, Lenburg ME, Spira A. Comparison of smoking-induced gene expression on Affymetrix Exon and 3'-based expression arrays. Genome Informatics. International Conference On Genome Informatics. 18: 247-57. PMID 18546492 DOI: 10.11234/Gi1990.18.247  0.397
2007 Beane J, Sebastiani P, Liu G, Brody JS, Lenburg ME, Spira A. Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression. Genome Biology. 8: R201. PMID 17894889 DOI: 10.1186/Gb-2007-8-9-R201  0.655
2007 Spira A, Beane JE, Shah V, Steiling K, Liu G, Schembri F, Gilman S, Dumas YM, Calner P, Sebastiani P, Sridhar S, Beamis J, Lamb C, Anderson T, Gerry N, et al. Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Nature Medicine. 13: 361-6. PMID 17334370 DOI: 10.1038/Nm1556  0.754
2006 Brody JS, Spira A. State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer. Proceedings of the American Thoracic Society. 3: 535-7. PMID 16921139 DOI: 10.1513/pats.200603-089MS  0.44
2006 DeMeo D, Mariani T, Lange C, Lake S, Litonjua A, Celedón J, Reilly J, Chapman HA, Sparrow D, Spira A, Beane J, Pinto-Plata V, Speizer FE, Shapiro S, Weiss ST, et al. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society. 3: 502. PMID 16921128 DOI: 10.1513/pats.200603-070MS  0.62
2006 Millien G, Spira A, Hinds A, Wang J, Williams MC, Ramirez MI. Alterations in gene expression in T1 alpha null lung: a model of deficient alveolar sac development. Bmc Developmental Biology. 6: 35. PMID 16869965 DOI: 10.1186/1471-213X-6-35  0.407
2006 Demeo D, Mariani T, Lange C, Srisuma S, Litonjua A, Celedon J, Lake S, Reilly J, Chapman H, Mecham B, Haley K, Sylvia J, Sparrow D, Spira A, Beane J, et al. The SERPINE2 gene is associated with chronic obstructive pulmonary disease Respiratory Medicine: Copd Update. 1: 143. DOI: 10.1016/J.Rmedu.2006.03.030  0.62
2005 Shah V, Sridhar S, Beane J, Brody JS, Spira A. SIEGE: Smoking Induced Epithelial Gene Expression Database. Nucleic Acids Research. 33: D573-9. PMID 15608264 DOI: 10.1093/Nar/Gki035  0.675
2004 Spira A, Beane J, Pinto-Plata V, Kadar A, Liu G, Shah V, Celli B, Brody JS. Gene expression profiling of human lung tissue from smokers with severe emphysema. American Journal of Respiratory Cell and Molecular Biology. 31: 601-10. PMID 15374838 DOI: 10.1165/Rcmb.2004-0273Oc  0.73
2004 Spira A, Beane J, Shah V, Liu G, Schembri F, Yang X, Palma J, Brody JS. Effects of cigarette smoke on the human airway epithelial cell transcriptome. Proceedings of the National Academy of Sciences of the United States of America. 101: 10143-8. PMID 15210990 DOI: 10.1073/Pnas.0401422101  0.718
2004 Spira A, Schembri F, Beane J, Shah V, Liu G, Brody JS. Impact of cigarette smoke on the normal airway transcriptome. Chest. 125: 115S. PMID 15136455 DOI: 10.1378/Chest.125.5_Suppl.115S  0.63
2004 Spira A, Beane J, Schembri F, Liu G, Ding C, Gilman S, Yang X, Cantor C, Brody JS. Noninvasive method for obtaining RNA from buccal mucosa epithelial cells for gene expression profiling. Biotechniques. 36: 484-7. PMID 15038164 DOI: 10.2144/04363Rn03  0.633
2003 Powell CA, Spira A, Derti A, DeLisi C, Liu G, Borczuk A, Busch S, Sahasrabudhe S, Chen Y, Sugarbaker D, Bueno R, Richards WG, Brody JS. Gene expression in lung adenocarcinomas of smokers and nonsmokers. American Journal of Respiratory Cell and Molecular Biology. 29: 157-62. PMID 12600827 DOI: 10.1165/Rcmb.2002-0183Rc  0.47
Low-probability matches (unlikely to be authored by this person)
2016 Kensler TW, Spira A, Garber JE, Szabo E, Lee JJ, Dong Z, Dannenberg AJ, Hait WN, Blackburn E, Davidson NE, Foti M, Lippman SM. Transforming Cancer Prevention through Precision Medicine and Immune-oncology. Cancer Prevention Research (Philadelphia, Pa.). 9: 2-10. PMID 26744449 DOI: 10.1158/1940-6207.Capr-15-0406  0.3
2018 Wu AC, Kiley JP, Noel PJ, Amur S, Burchard EG, Clancy JP, Galanter J, Inada M, Jones TK, Kropski JA, Loyd JE, Nogee LM, Raby BA, Rogers AJ, Schwartz DA, ... ... Spira A, et al. Current Status and Future Opportunities in Lung Precision Medicine Research with a Focus on Biomarkers. An American Thoracic Society/National Heart, Lung, and Blood Institute Research Statement. American Journal of Respiratory and Critical Care Medicine. 198: e116-e136. PMID 30640517 DOI: 10.1164/Rccm.201810-1895St  0.296
2017 Drizik EI, Corbett S, Vermeulen R, Dai Y, Hu W, Lenburg M, Ren D, Duan H, Niu Y, Xu J, Fu W, Meliefste K, Zhou B, Yang J, Ye M, ... ... Spira A, et al. Abstract 4256: Impact of diesel engine exhaust exposure on the airway transcriptome Cancer Research. 77: 4256-4256. DOI: 10.1158/1538-7445.Am2017-4256  0.293
2021 Sinjab A, Han G, Treekitkarnmongkol W, Hara K, Brennan PM, Dang M, Hao D, Wang R, Dai E, Dejima H, Zhang J, Bogatenkova E, Sanchez-Espiridion B, Chang K, Little DR, ... ... Spira A, et al. Resolving the spatial and cellular architecture of lung adenocarcinoma by multiregion single-cell sequencing. Cancer Discovery. PMID 33972311 DOI: 10.1158/2159-8290.CD-20-1285  0.293
2016 Fehrenbacher L, Spira A, Ballinger M, Kowanetz M, Vansteenkiste J, Mazieres J, Park K, Smith D, Artal-Cortes A, Lewanski C, Braiteh F, Waterkamp D, He P, Zou W, Chen DS, et al. Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial. Lancet (London, England). PMID 26970723 DOI: 10.1016/S0140-6736(16)00587-0  0.292
2013 Reynolds C, Spira AI, Gluck L, Bradie-Muller SJ, Mueller SE, Zhan F, Boehm KA, Asmar L. Sunitinib malate in previously untreated, nonsquamous, non-small cell lung cancer patients over the age of 70 years: results of a Phase II trial. Investigational New Drugs. 31: 1330-8. PMID 23761052 DOI: 10.1007/s10637-013-9985-0  0.291
2021 Xu F, Tanabe N, Vasilescu DM, McDonough JE, Coxson HC, Ikezoe K, Kinose D, Ng KW, Verleden SE, Wuyts WA, Vanaudenaerde BM, Verschakelen J, Cooper JD, Lenburg ME, Morshead KB, ... ... Spira A, et al. The transition from normal lung anatomy to minimal and established fibrosis in idiopathic pulmonary fibrosis (IPF). Ebiomedicine. 66: 103325. PMID 33862585 DOI: 10.1016/j.ebiom.2021.103325  0.282
2009 Reynolds C, Barrera D, Jotte R, Spira AI, Weissman C, Boehm KA, Pritchard S, Asmar L. Phase II trial of nanoparticle albumin-bound paclitaxel, carboplatin, and bevacizumab in first-line patients with advanced nonsquamous non-small cell lung cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 4: 1537-43. PMID 19887966 DOI: 10.1097/JTO.0b013e3181c0a2f4  0.28
2011 Gower AC, Spira A, Lenburg ME. Discovering biological connections between experimental conditions based on common patterns of differential gene expression. Bmc Bioinformatics. 12: 381. PMID 21951600 DOI: 10.1186/1471-2105-12-381  0.278
2016 Faner R, Cruz T, Casserras T, López-Giraldo A, Noell G, Coca I, Tal-Singer R, Miller B, Rodriguez-Roisin R, Spira A, Kalko SG, Agusti A. Network Analysis of Lung Transcriptomics Reveals a Distinct B Cell Signature in Emphysema. American Journal of Respiratory and Critical Care Medicine. PMID 26735770 DOI: 10.1164/Rccm.201507-1311Oc  0.277
2013 Hijazi K, Malyszko B, Steiling K, Zhang X, Liu G, Alekseyev Y, Xiao J, Dumas M, Hertsgaard L, Jenson J, Rohde C, Isaksson R, Hatsukami D, Hecht S, Brooks D, ... ... Spira A, et al. Abstract 4030: Nasal gene expression reflects the physiologic response to alternate tobacco products. Cancer Research. 73: 4030-4030. DOI: 10.1158/1538-7445.Am2013-4030  0.273
2016 Faiz A, Postma DS, Koppelman GH, Hiemstra PS, Sterk PJ, Timens W, Steiling K, Spira A, Heijink IH, Berge Mvd. FKBP5 a candidate for corticosteroid insensitivity in COPD European Respiratory Journal. 48. DOI: 10.1183/13993003.Congress-2016.Oa1779  0.272
2012 Spira A, Nana-Sinkam SP. Using microRNAs to inform clinical decision making in lung cancer: ready for prime time? American Journal of Respiratory and Critical Care Medicine. 186: 1077-9. PMID 23204375 DOI: 10.1164/Rccm.201210-1757Ed  0.271
2009 Schembri F, Sridhar S, Perdomo C, Gustafson AM, Zhang X, Ergun A, Lu J, Liu G, Zhang X, Bowers J, Vaziri C, Ott K, Sensinger K, Collins JJ, Brody JS, ... ... Spira A, et al. MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proceedings of the National Academy of Sciences of the United States of America. 106: 2319-24. PMID 19168627 DOI: 10.1073/Pnas.0806383106  0.268
2014 Park SJ, Walser TC, Perdomo C, Wang T, Pagano PC, Liclican EL, Krysan K, Larsen JE, Minna JD, Lenburg ME, Spira A, Dubinett SM. Abstract B16: The effect of e-cigarette exposure on airway epithelial cell gene expression and transformation. Clinical Cancer Research. 20: B16-B16. DOI: 10.1158/1078-0432.14AACRIASLC-B16  0.268
2020 Lamb C, Lenburg M, Wilde J, Lofaro L, Hao Y, Huang J, Stevenson C, Whitney D, Bhorade S, Kennedy G, Spira A. DISTINGUISHING CURRENT VS FORMER SMOKERS USING WHOLE TRANSCRIPTOME RNASEQ OF BRONCHIAL AND NASAL AIRWAY EPITHELIUM Chest. 158: A1450-A1451. DOI: 10.1016/j.chest.2020.08.1311  0.264
2017 Ong J, Timens W, Rajendran V, Algra A, Spira A, Lenburg ME, Campbell JD, van den Berge M, Postma DS, van den Berg A, Kluiver J, Brandsma CA. Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts. Plos One. 12: e0183815. PMID 28910321 DOI: 10.1371/Journal.Pone.0183815  0.263
2016 Tellez CS, Juri DE, Do K, Picchi MA, Wang T, Liu G, Spira A, Belinsky SA. Abstract 958: MiR-196b is an epigenetically silenced tumor suppressor for lung cancer Cancer Research. 76: 958-958. DOI: 10.1158/1538-7445.Am2016-958  0.25
2016 Faiz A, Postma D, Koppelman G, Hiemstra P, Sterk P, Timens W, Steiling K, Spira A, Heijink I, Berge Mvd. LSC Abstract – Inducible expression quantitative trait loci: A novel method to identifying genetic variants associated with corticosteroid responsiveness in COPD European Respiratory Journal. 48: 136. DOI: 10.1183/13993003.Congress-2016.Pp136  0.25
2014 Levy B, Spira A, Becker D, Evans T, Schnadig I, Camidge DR, Bauman JE, Hausman D, Walker L, Nemunaitis J, Rudin CM, Halmos B, Bowles DW. A randomized, phase 2 trial of Docetaxel with or without PX-866, an irreversible oral phosphatidylinositol 3-kinase inhibitor, in patients with relapsed or metastatic non-small-cell lung cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 9: 1031-5. PMID 24926548 DOI: 10.1097/JTO.0000000000000183  0.247
2018 Christenson SA, van den Berge M, Faiz A, Imkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, ... ... Spira A, et al. An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup. The Journal of Clinical Investigation. PMID 30383540 DOI: 10.1172/Jci121087  0.246
2014 Krysan K, Kusko R, Grogan T, O'Hearn J, Reckamp KL, Walser TC, Garon EB, Lenburg ME, Sharma S, Spira AE, Elashoff D, Dubinett SM. PGE2-driven expression of c-Myc and oncomiR-17-92 contributes to apoptosis resistance in NSCLC. Molecular Cancer Research : McR. 12: 765-74. PMID 24469837 DOI: 10.1158/1541-7786.Mcr-13-0377  0.242
2016 Spira A, Disis ML, Schiller JT, Vilar E, Rebbeck TR, Bejar R, Ideker T, Arts J, Yurgelun MB, Mesirov JP, Rao A, Garber J, Jaffee EM, Lippman SM. Leveraging premalignant biology for immune-based cancer prevention. Proceedings of the National Academy of Sciences of the United States of America. PMID 27638202 DOI: 10.1073/Pnas.1608077113  0.242
2020 Drizik E, Corbett S, Zheng Y, Vermeulen R, Dai Y, Hu W, Ren D, Duan H, Niu Y, Xu J, Fu W, Meliefste K, Zhou B, Zhang X, Yang J, ... ... Spira A, et al. Transcriptomic changes in the nasal epithelium associated with diesel engine exhaust exposure. Environment International. 137: 105506. PMID 32044442 DOI: 10.1016/J.Envint.2020.105506  0.241
2020 Lee HJ, Mazzone P, Feller-Kopman D, Yarmus L, Hogarth K, Lofaro LR, Griscom B, Johnson M, Choi Y, Huang J, Bhorade S, Spira A, Kennedy GC, Wahidi MM. Impact of the Percepta Genomic Classifier on Clinical Management Decisions in a Multicenter Prospective Study. Chest. PMID 32758562 DOI: 10.1016/J.Chest.2020.07.067  0.237
2009 Silverman EK, Spira A, Paré PD. Genetics and genomics of chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society. 6: 539-42. PMID 19741265 DOI: 10.1513/pats.200904-021DS  0.236
2015 Christenson SA, Steiling K, van den Berge M, Hijazi K, Hiemstra PS, Postma DS, Lenburg ME, Spira A, Woodruff PG. Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine. 191: 758-66. PMID 25611785 DOI: 10.1164/Rccm.201408-1458Oc  0.235
2020 Rozenblatt-Rosen O, Regev A, Oberdoerffer P, Nawy T, Hupalowska A, Rood JE, Ashenberg O, Cerami E, Coffey RJ, Demir E, Ding L, Esplin ED, Ford JM, Goecks J, Ghosh S, ... ... Spira AE, et al. The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution. Cell. 181: 236-249. PMID 32302568 DOI: 10.1016/J.Cell.2020.03.053  0.232
2017 Gower AC, Spira A, Lenburg ME. 2356 Journal of Clinical and Translational Science. 1: 16-16. DOI: 10.1017/cts.2017.71  0.227
2017 Spira A, Yurgelun MB, Alexandrov L, Rao A, Bejar R, Polyak K, Giannakis M, Shilatifard A, Finn OJ, Dhodapkar M, Kay NE, Braggio E, Vilar E, Mazzilli SA, Rebbeck TR, et al. Precancer Atlas to Drive Precision Prevention Trials. Cancer Research. 77: 1510-1541. PMID 28373404 DOI: 10.1158/0008-5472.Can-16-2346  0.226
2012 Witta SE, Jotte RM, Konduri K, Neubauer MA, Spira AI, Ruxer RL, Varella-Garcia M, Bunn PA, Hirsch FR. Randomized phase II trial of erlotinib with and without entinostat in patients with advanced non-small-cell lung cancer who progressed on prior chemotherapy Journal of Clinical Oncology. 30: 2248-2255. PMID 22508830 DOI: 10.1200/JCO.2011.38.9411  0.22
2016 Chitsazzadeh V, Coarfa C, Drummond JA, Nguyen T, Joseph A, Chilukuri S, Charpiot E, Adelmann CH, Ching G, Nguyen TN, Nicholas C, Thomas VD, Migden M, MacFarlane D, Thompson E, ... ... Spira A, et al. Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates. Nature Communications. 7: 12601. PMID 27574101 DOI: 10.1038/Ncomms12601  0.219
2016 Piccolo SR, Hoffman LM, Conner T, Shrestha G, Cohen AL, Marks JR, Neumayer LA, Agarwal CA, Beckerle MC, Andrulis IL, Spira AE, Moos PJ, Buys SS, Johnson WE, Bild AH. Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility. Molecular Systems Biology. 12: 860. PMID 26969729 DOI: 10.15252/Msb.20156506  0.216
2016 Tellez CS, Juri DE, Do KC, Picchi MA, Wang T, Liu G, Spira AE, Belinsky SA. MiR-196b is epigenetically silenced during the pre-malignant stage of lung carcinogenesis. Cancer Research. PMID 27302168 DOI: 10.1158/0008-5472.CAN-15-3367  0.215
2015 Piccolo SR, Andrulis IL, Cohen AL, Conner T, Moos PJ, Spira AE, Buys SS, Johnson WE, Bild AH. Gene-expression patterns in peripheral blood classify familial breast cancer susceptibility. Bmc Medical Genomics. 8: 72. PMID 26538066 DOI: 10.1186/s12920-015-0145-6  0.212
2021 Xu F, Vasilescu DM, Kinose D, Tanabe N, Ng KW, Coxson HO, Cooper JD, Hackett TL, Verleden SE, Vanaudenaerde BM, Stevenson CS, Lenburg ME, Spira A, Tan WC, Sin DD, et al. The molecular and cellular mechanisms associated with the destruction of terminal bronchioles in chronic obstructive pulmonary disease. The European Respiratory Journal. PMID 34675046 DOI: 10.1183/13993003.01411-2021  0.209
2015 Grayson PC, Steiling K, Platt M, Berman JS, Zhang X, Xiao J, Alekseyev YO, Liu G, Monach PA, Kaplan MJ, Spira A, Merkel PA. Brief Report: Defining the Nasal Transcriptome in Granulomatosis With Polyangiitis (Wegener's). Arthritis & Rheumatology (Hoboken, N.J.). 67: 2233-9. PMID 25939343 DOI: 10.1002/Art.39185  0.207
2008 Sequist LV, Martins RG, Spigel D, Grunberg SM, Spira A, Jänne PA, Joshi VA, McCollum D, Evans TL, Muzikansky A, Kuhlmann GL, Han M, Goldberg JS, Settleman J, Iafrate AJ, et al. First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 2442-9. PMID 18458038 DOI: 10.1200/Jco.2007.14.8494  0.206
2012 Belinsky SA, Spira A, Tellez C. Abstract CN06-02: Epigenetic Deregulation of MicroRNAs During Tobacco Carcinogen-Induced Transformation of Bronchial Epithelial Cells Cancer Prevention Research. 5: CN06-02-CN06-02. DOI: 10.1158/1940-6207.PREV-12-CN06-02  0.204
2016 Imkamp K, Faiz A, Wiel Evd, Boudewijn I, Koppelman G, Brandsma C, Kerstjens H, Timens W, Vroegop S, Pasma H, Boersma W, Wielders P, Elshout Fvd, Mansour K, Steiling K, ... Spira A, et al. Effects of ICS/LABA treatment on hyperinflation and genome wide gene-expression in upper airway epithelium in severe COPD European Respiratory Journal. 48. DOI: 10.1183/13993003.Congress-2016.Pa1203  0.204
2009 Bild A, Sun Y, Soldi R, Conner T, Walker D, Werner T, Spira A, Andrulis I, Buys S, Johnson E. A Genomic Biomarker for Breast Cancer Development in High-Risk Women. Cancer Research. 69: 4059-4059. DOI: 10.1158/0008-5472.Sabcs-09-4059  0.201
2018 Reyfman PA, Washko GR, Dransfield MT, Spira A, Han MK, Kalhan R. Defining Impaired Respiratory Health: A Paradigm Shift for Pulmonary Medicine. American Journal of Respiratory and Critical Care Medicine. PMID 29624449 DOI: 10.1164/Rccm.201801-0120Pp  0.2
2011 Christodoulou C, Longmire TA, Shen SS, Bourdon A, Sommer CA, Gadue P, Spira A, Gouon-Evans V, Murphy GJ, Mostoslavsky G, Kotton DN. Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes. The Journal of Clinical Investigation. 121: 2313-25. PMID 21537085 DOI: 10.1172/Jci43853  0.2
2018 Bals R, Boyd J, Esposito S, Foronjy R, Hiemstra PS, Jiménez-Ruiz CA, Katsaounou P, Lindberg A, Metz C, Schober W, Spira A, Blasi F. Electronic Cigarettes - Task Force report from the European Respiratory Society. The European Respiratory Journal. PMID 30464018 DOI: 10.1183/13993003.01151-2018  0.196
2015 Faiz A, Borggrewe M, Postma D, Steiling K, Spira A, Lenburg M, Jonker M, Koppelman G, Hiemstra P, Sterk P, Timens W, Brandsma C, Berge MVd, Heijink I. MiR-320d: A novel anti-inflammatory miRNA up regulated by corticosteroids European Respiratory Journal. 46. DOI: 10.1183/13993003.Congress-2015.Oa2927  0.195
1998 Spira A, Grossman R, Balter M. Large airway disease associated with inflammatory bowel disease. Chest. 113: 1723-6. PMID 9631822 DOI: 10.1378/CHEST.113.6.1723  0.184
2013 Krysan K, Cui X, Gardner BK, Reckamp KL, Wang X, Hong L, Walser TC, Rodriguez NL, Pagano PC, Garon EB, Brothers JF, Elashoff D, Lee JM, Spira AE, Sharma S, et al. Elevated neutrophil gelatinase-associated lipocalin contributes to erlotinib resistance in non-small cell lung cancer. American Journal of Translational Research. 5: 481-96. PMID 23977408  0.184
2012 Spira AI, Iannotti NO, Savin MA, Neubauer M, Gabrail NY, Yanagihara RH, Zang EA, Cole PE, Shuster D, Das A. A phase II study of eribulin mesylate (E7389) in patients with advanced, previously treated nonsmall-cell lung cancer Clinical Lung Cancer. 13: 31-38. PMID 21862415 DOI: 10.1016/j.cllc.2011.06.010  0.182
2019 Faiz A, Steiling K, Roffel MP, Postma DS, Spira A, Lenburg ME, Borggrewe M, Eijgenraam TR, Jonker MR, Koppelman GH, Pouwels SD, Liu G, Alekseyev YO, Lam S, Hiemstra PS, et al. Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in Chronic Obstructive Pulmonary Disease. The European Respiratory Journal. PMID 30846474 DOI: 10.1183/13993003.01202-2018  0.179
2014 Yoo S, Huang T, Campbell JD, Lee E, Tu Z, Geraci MW, Powell CA, Schadt EE, Spira A, Zhu J. MODMatcher: multi-omics data matcher for integrative genomic analysis. Plos Computational Biology. 10: e1003790. PMID 25122495 DOI: 10.1371/Journal.Pcbi.1003790  0.178
2009 Soldi R, Gustafson A, Zhu H, Wilcox R, Welm B, Spira A, Jeffrey S, Bild A. A Phenotype-Based Model for Rational Selection of Novel Targeted Therapies in Treating Aggressive Breast Cancer. Cancer Research. 69: 2007-2007. DOI: 10.1158/0008-5472.Sabcs-09-2007  0.178
2021 Kammer MN, Lakhani DA, Balar AB, Antic SL, Kussrow AK, Webster RL, Mahapatra S, Barad U, Shah C, Atwater T, Diergaarde B, Qian J, Kaizer A, New M, Hirsch E, ... ... Spira A, et al. Integrated Biomarkers for the Management of Indeterminate Pulmonary Nodules. American Journal of Respiratory and Critical Care Medicine. PMID 34464235 DOI: 10.1164/rccm.202012-4438OC  0.178
2015 Wilson AA, Ying L, Liesa M, Segeritz CP, Mills JA, Shen SS, Jean J, Lonza GC, Liberti DC, Lang AH, Nazaire J, Gower AC, Müeller FJ, Mehta P, Ordóñez A, ... ... Spira A, et al. Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells. Stem Cell Reports. 4: 873-85. PMID 25843048 DOI: 10.1016/J.Stemcr.2015.02.021  0.175
2016 Vasilescu DM, Phillion AB, Tanabe N, Kinose D, Paige DF, Kantrowitz JJ, Liu G, Liu H, Fishbane N, Verleden SE, Vanaudenaerde BM, Lenburg ME, Stevenson CS, Spira A, Cooper JD, et al. Non-destructive cryo micro CT imaging enables structural and molecular analysis of human lung tissue. Journal of Applied Physiology (Bethesda, Md. : 1985). jap.00838.2016. PMID 27856720 DOI: 10.1152/Japplphysiol.00838.2016  0.175
2011 Perdomo C, Spira A, Schembri F. MiRNAs as regulators of the response to inhaled environmental toxins and airway carcinogenesis. Mutation Research. 717: 32-7. PMID 21549133 DOI: 10.1016/J.Mrfmmm.2011.04.005  0.174
2008 Gitin Y, Farraye FA, Zhang X, Liu G, Spira A, Brody JS. M2066 Evaluation of Global Gene Expression in Rectal Mucosa Obtained By a Non-Invasive Technique in Patients with Ulcerative Colitis Gastroenterology. 134: A-462. DOI: 10.1016/S0016-5085(08)62159-9  0.172
2018 Pine PS, Lund SP, Parsons JR, Vang LK, Mahabal AA, Cinquini L, Kelly SC, Kincaid H, Crichton DJ, Spira A, Liu G, Gower AC, Pass HI, Goparaju C, Dubinett SM, et al. Summarizing performance for genome scale measurement of miRNA: reference samples and metrics. Bmc Genomics. 19: 180. PMID 29510677 DOI: 10.1186/S12864-018-4496-1  0.172
2013 Mills JA, Wang K, Paluru P, Ying L, Lu L, Galvão AM, Xu D, Yao Y, Sullivan SK, Sullivan LM, Mac H, Omari A, Jean JC, Shen S, Gower A, ... Spira A, et al. Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines. Blood. 122: 2047-51. PMID 23940280 DOI: 10.1182/Blood-2013-02-484444  0.169
2000 Spira A, Gutierrez C, Chaparro C, Hutcheon MA, Chan CK. Osteoporosis and lung transplantation: a prospective study. Chest. 117: 476-81. PMID 10669693 DOI: 10.1378/CHEST.117.2.476  0.169
2003 Spira A, Carroll JD, Liu G, Aziz Z, Shah V, Kornfeld H, Keane J. Apoptosis genes in human alveolar macrophages infected with virulent or attenuated Mycobacterium tuberculosis: a pivotal role for tumor necrosis factor. American Journal of Respiratory Cell and Molecular Biology. 29: 545-51. PMID 12748057 DOI: 10.1165/Rcmb.2002-0310Oc  0.163
2017 Ong J, Timens W, Rajendran V, Algra A, Spira A, Lenburg M, Campbell J, Berge Mvd, Postma D, Berg Avd, Kluiver J, Brandsma C. Target gene identification of TGF-beta-induced miR-455-3p and miR-21-3p in lung fibroblasts European Respiratory Journal. 50. DOI: 10.1183/1393003.Congress-2017.Pa1025  0.162
2018 Tasena H, Faiz A, Timens W, Noordhoek J, Hylkema MN, Gosens R, Hiemstra PS, Spira A, Postma DS, Tew GW, Grimbaldeston MA, van den Berge M, Heijink IH, Brandsma CA. microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD. The European Respiratory Journal. PMID 30072506 DOI: 10.1183/13993003.01556-2017  0.162
2011 Cohen AL, Soldi R, Zhang H, Gustafson AM, Wilcox R, Welm BE, Chang JT, Johnson E, Spira A, Jeffrey SS, Bild AH. A pharmacogenomic method for individualized prediction of drug sensitivity. Molecular Systems Biology. 7: 513. PMID 21772261 DOI: 10.1038/Msb.2011.47  0.159
2012 Sommer CA, Christodoulou C, Gianotti-Sommer A, Shen SS, Sailaja BS, Hezroni H, Spira A, Meshorer E, Kotton DN, Mostoslavsky G. Residual expression of reprogramming factors affects the transcriptional program and epigenetic signatures of induced pluripotent stem cells. Plos One. 7: e51711. PMID 23272148 DOI: 10.1371/Journal.Pone.0051711  0.157
2014 Stadler WM, Vaughn DJ, Sonpavde G, Vogelzang NJ, Tagawa ST, Petrylak DP, Rosen P, Lin CC, Mahoney J, Modi S, Lee P, Ernstoff MS, Su WC, Spira A, Pilz K, et al. An open-label, single-arm, phase 2 trial of the Polo-like kinase inhibitor volasertib (BI 6727) in patients with locally advanced or metastatic urothelial cancer. Cancer. 120: 976-82. PMID 24339028 DOI: 10.1002/cncr.28519  0.153
2010 Wu J, Qian J, Li C, Kwok L, Cheng F, Liu P, Perdomo C, Kotton D, Vaziri C, Anderlind C, Spira A, Cardoso WV, Lü J. miR-129 regulates cell proliferation by downregulating Cdk6 expression. Cell Cycle (Georgetown, Tex.). 9: 1809-18. PMID 20404570 DOI: 10.4161/Cc.9.9.11535  0.148
2002 Spira A, Brecher S, Karlinsky J. Pulmonary mucormycosis in the setting of chronic obstructive pulmonary disease. A case report and review of the literature. Respiration; International Review of Thoracic Diseases. 69: 560-3. PMID 12457013 DOI: 10.1159/000066467  0.146
2016 Reed E, Bray D, Lam S, van den Berge M, Liu G, Zhang X, Alekseyev Y, Spira A, Lenburg M, Steiling K. Data-Driven Identification of Novel Molecular Subclasses of COPD Chest. 150: 916A. DOI: 10.1016/J.Chest.2016.08.1016  0.141
2016 Park SJ, Walser TC, Tran LM, Perdomo C, Wang T, Hong L, Pagano P, Li R, Jing Z, Liclican E, Larsen JE, Krysan K, Fishbein MC, Minna JD, Lenburg ME, ... Spira A, et al. The biological impact of e-cigarettes on airway epithelial cell transformation and gene expression Journal of Thoracic Oncology. 11: S35-S36. DOI: 10.1016/J.Jtho.2015.12.060  0.139
2017 Gold DR, Adamkiewicz G, Arshad SH, Celedón JC, Chapman MD, Chew GL, Cook DN, Custovic A, Gehring U, Gern JE, Johnson CC, Kennedy S, Koutrakis P, Leaderer B, Mitchell H, ... ... Spira A, et al. NIAID, NIEHS, NHLBI, MCAN Workshop Report: The Indoor Environment and Childhood Asthma: Implications for Home Environmental Intervention in Asthma Prevention and Management. The Journal of Allergy and Clinical Immunology. PMID 28502823 DOI: 10.1016/J.Jaci.2017.04.024  0.135
2010 Messersmith WA, Jimeno A, Jacene H, Zhao M, Kulesza P, Laheru DA, Kahn Y, Spira A, Dancey J, Iacobuzio-Donahue C, Donehower RC, Carducci M, Rudek MA, Hidalgo M. Phase I trial of oxaliplatin, infusional 5-fluorouracil, and leucovorin (FOLFOX4) with erlotinib and bevacizumab in colorectal cancer. Clinical Colorectal Cancer. 9: 297-304. PMID 21208844 DOI: 10.3816/Ccc.2010.N.043  0.134
2015 Jimeno A, Bauman JE, Weissman C, Adkins D, Schnadig I, Beauregard P, Bowles DW, Spira A, Levy B, Seetharamu N, Hausman D, Walker L, Rudin CM, Shirai K. A randomized, phase 2 trial of docetaxel with or without PX-866, an irreversible oral phosphatidylinositol 3-kinase inhibitor, in patients with relapsed or metastatic head and neck squamous cell cancer. Oral Oncology. 51: 383-8. PMID 25593016 DOI: 10.1016/j.oraloncology.2014.12.013  0.134
2015 Jimeno A, Shirai K, Choi M, Laskin J, Kochenderfer M, Spira A, Cline-Burkhardt V, Winquist E, Hausman D, Walker L, Cohen RB. A randomized, phase II trial of cetuximab with or without PX-866, an irreversible oral phosphatidylinositol 3-kinase inhibitor, in patients with relapsed or metastatic head and neck squamous cell cancer. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. 26: 556-61. PMID 25524478 DOI: 10.1093/annonc/mdu574  0.131
2019 Zhang T, Chillrud SN, Yang Q, Pitiranggon M, Ross J, Perera F, Ji J, Spira A, Breysse PN, Rodes C, Miller R, Yan B. Characterizing peak exposure of secondhand smoke using a real-time PM monitor. Indoor Air. PMID 31610044 DOI: 10.1111/Ina.12611  0.125
2015 Maxwell EK, Campbell JD, Spira A, Baxevanis AD. SubmiRine: assessing variants in microRNA targets using clinical genomic data sets. Nucleic Acids Research. 43: 3886-98. PMID 25813044 DOI: 10.1093/Nar/Gkv256  0.123
2010 Le Goaster C, Ringa V, Spira A. From 2009... to 2010 Revue D'Epidemiologie Et De Sante Publique. 58: 1. DOI: 10.1016/j.respe.2009.12.010  0.12
2015 Vachani A, Parsons E, Ferguson J, Whitney D, Porta K, Rosenbluth M, Silvestri G, Spira A. Clinical Utility of a Bronchial Genomic Classifier: An Analysis of Invasive Procedure Utilization in the AEGIS Trials Chest. 148: 545A. DOI: 10.1378/chest.2270755  0.111
2014 Pierobon M, Silvestri A, Spira A, Reeder A, Pin E, Banks S, Parasido E, Edmiston K, Liotta L, Petricoin E. Pilot phase I/II personalized therapy trial for metastatic colorectal cancer: evaluating the feasibility of protein pathway activation mapping for stratifying patients to therapy with imatinib and panitumumab. Journal of Proteome Research. 13: 2846-55. PMID 24787230 DOI: 10.1021/pr401267m  0.104
2013 Smith DC, Smith MR, Sweeney C, Elfiky AA, Logothetis C, Corn PG, Vogelzang NJ, Small EJ, Harzstark AL, Gordon MS, Vaishampayan UN, Haas NB, Spira AI, Lara PN, Lin CC, et al. Cabozantinib in patients with advanced prostate cancer: results of a phase II randomized discontinuation trial. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 412-9. PMID 23169517 DOI: 10.1200/JCO.2012.45.0494  0.102
2016 Bowles DW, Kochenderfer M, Cohn A, Sideris L, Nguyen N, Cline-Burkhardt V, Schnadig I, Choi M, Nabell L, Chaudhry A, Ruxer R, Ucar A, Hausman D, Walker L, Spira A, et al. A Randomized, Phase II Trial of Cetuximab With or Without PX-866, an Irreversible Oral Phosphatidylinositol 3-Kinase Inhibitor, in Patients With Metastatic Colorectal Carcinoma. Clinical Colorectal Cancer. PMID 27118441 DOI: 10.1016/j.clcc.2016.03.004  0.099
2012 Spira A, Edmiston KH. Clinical trial design in the age of molecular profiling Methods in Molecular Biology. 823: 19-34. PMID 22081336 DOI: 10.1007/978-1-60327-216-2_2  0.097
2013 Hossein-nezhad A, Spira A, Holick MF. Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial. Plos One. 8: e58725. PMID 23527013 DOI: 10.1371/Journal.Pone.0058725  0.094
2020 Sofer T, Li R, Joehanes R, Lin H, Gower AC, Wang H, Kurniansyah N, Cade BE, Lee J, Williams S, Mehra R, Patel SR, Quan SF, Liu Y, Rotter JI, ... ... Spira A, et al. Low oxygen saturation during sleep reduces CD1D and RAB20 expressions that are reversed by CPAP therapy. Ebiomedicine. 56: 102803. PMID 32512511 DOI: 10.1016/J.Ebiom.2020.102803  0.087
2012 Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algül H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP. Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice. The Journal of Clinical Investigation. 122: 1758-63. PMID 22466650 DOI: 10.1172/Jci59408  0.085
2019 Sofer T, Li R, Joehanes R, Lin H, Gower A, Punjabi N, Mehra R, Patel S, Quan S, Liu Y, Gharib S, Levy D, Spira A, Redline S, Gottlieb D. 0021 Lower Oxygen Saturation During Sleep Is Associated With Reduced Expressions Of Cd1d And Rab20 That Is Potentially Reversed By CPAP Therapy Sleep. 42: A8-A9. DOI: 10.1093/Sleep/Zsz067.020  0.083
1991 Coste J, Spira A, Ducimetiere P, Paolaggi J. Clinical and psychological diversity of non-specific low-back pain. A new approach towards the classification of clinical subgroups Journal of Clinical Epidemiology. 44: 1233-1245. PMID 1834806 DOI: 10.1016/0895-4356(91)90156-4  0.078
2013 Spira A. [Large health cohorts in France]. Bulletin De L'AcadéMie Nationale De MéDecine. 197: 315-28; discussion 3. PMID 24919362  0.076
2013 Bouchard P, Spira A, Ville Y, Conard J, Sitruk-Ware R. Oral contraceptive and vascular risk Bulletin De L'Academie Nationale De Medecine. 197: 485-502.  0.074
2013 Ramsey CM, Spira AP, Mojtabai R, Eaton WW, Roth K, Lee HB. Lifetime manic spectrum episodes and all-cause mortality: 26-year follow-up of the NIMH Epidemiologic Catchment Area Study. Journal of Affective Disorders. 151: 337-42. PMID 23835104 DOI: 10.1016/J.Jad.2013.06.019  0.074
2016 Wennberg AMV, Spira AP, Pettigrew C, Soldan A, Zipunnikov V, Rebok GW, Roses AD, Lutz MW, Miller MM, Thambisetty M, Albert MS. Blood glucose levels and cortical thinning in cognitively normal, middle-aged adults Journal of the Neurological Sciences. 365: 89-95. DOI: 10.1016/j.jns.2016.04.017  0.07
2016 Wennberg AM, Spira AP, Pettigrew C, Soldan A, Zipunnikov V, Rebok GW, Roses AD, Lutz MW, Miller MM, Thambisetty M, Albert MS. Blood glucose levels and cortical thinning in cognitively normal, middle-aged adults. Journal of the Neurological Sciences. 365: 89-95. PMID 27206882 DOI: 10.1016/J.Jns.2016.04.017  0.069
2016 Dennis KK, Auerbach SS, Balshaw DM, Cui Y, Fallin MD, Smith MT, Spira A, Sumner S, Miller GW. The Importance of the Biological Impact of Exposure to the Concept of the Exposome. Environmental Health Perspectives. PMID 27258438 DOI: 10.1289/Ehp140  0.069
2011 Boutou-Kempf O, Marchand JL, Radauceanu A, Witschger O, Imbernon E, André JC, Bloch D, Boczkowski J, Brochard P, Chevallier R, Dab W, Fontaine M, Goldberg M, Honnert B, Luce D, ... ... Spira A, et al. Development of a French epidemiological surveillance system of workers producing or handling engineered nanomaterials in the workplace Journal of Occupational and Environmental Medicine. 53. PMID 21654409 DOI: 10.1097/JOM.0b013e31821b1d68  0.069
2013 Richards D, Kocs DM, Spira AI, David McCollum A, Diab S, Hecker LI, Cohn A, Zhan F, Asmar L. Results of docetaxel plus oxaliplatin (DOCOX) ± cetuximab in patients with metastatic gastric and/or gastroesophageal junction adenocarcinoma: results of a randomised Phase 2 study. European Journal of Cancer (Oxford, England : 1990). 49: 2823-31. PMID 23747051 DOI: 10.1016/j.ejca.2013.04.022  0.068
2015 Grayson PC, Steiling K, Platt M, Berman JS, Zhang X, Xiao J, Alekseyev YO, Liu G, Monach PA, Kaplan MJ, Spira A, Merkel PA. Brief report: Defining the nasal transcriptome in granulomatosis with polyangiitis (Wegener's) Arthritis and Rheumatology. 67: 2233-2239. DOI: 10.1002/art.39185  0.065
2014 Chen-Edinboro LP, Kaufmann CN, Augustinavicius JL, Mojtabai R, Parisi JM, Wennberg AM, Smith MT, Spira AP. Neighborhood physical disorder, social cohesion, and insomnia: results from participants over age 50 in the Health and Retirement Study. International Psychogeriatrics / Ipa. 1-8. PMID 25222023 DOI: 10.1017/S1041610214001823  0.062
2016 Petrylak DP, Tagawa ST, Kohli M, Eisen A, Canil C, Sridhar SS, Spira A, Yu EY, Burke JM, Shaffer D, Pan CX, Kim JJ, Aragon-Ching JB, Quinn DI, Vogelzang NJ, et al. Docetaxel As Monotherapy or Combined With Ramucirumab or Icrucumab in Second-Line Treatment for Locally Advanced or Metastatic Urothelial Carcinoma: An Open-Label, Three-Arm, Randomized Controlled Phase II Trial. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. PMID 26926681 DOI: 10.1200/JCO.2015.65.0218  0.059
1991 Coste J, Paolaggi JB, Spira A. Reliability of interpretation of plain lumbar spine radiographs in benign, mechanical low-back pain. Spine. 16: 426-8. PMID 1828626 DOI: 10.1097/00007632-199104000-00006  0.058
2015 Kaufmann CN, Spira AP, Alexander GC, Rutkow L, Mojtabai R. Trends in prescribing of sedative-hypnotic medications in the USA: 1993-2010. Pharmacoepidemiology and Drug Safety. PMID 26711081 DOI: 10.1002/Pds.3951  0.057
2015 Mauro PM, Canham SL, Martins SS, Spira AP. Substance-use coping and self-rated health among US middle-aged and older adults. Addictive Behaviors. 42: 96-100. PMID 25437264 DOI: 10.1016/j.addbeh.2014.10.031  0.055
2012 Kielb SA, Ancoli-Israel S, Rebok GW, Spira AP. Cognition in obstructive sleep apnea-hypopnea syndrome (OSAS): current clinical knowledge and the impact of treatment. Neuromolecular Medicine. 14: 180-93. PMID 22569877 DOI: 10.1007/S12017-012-8182-1  0.054
1992 Coste J, Paolaggi JB, Spira A. Classification of nonspecific low back pain. II. Clinical diversity of organic forms. Spine. 17: 1038-42. PMID 1411754 DOI: 10.1097/00007632-199209000-00005  0.052
2008 Lapostolle A, Lefranc A, Gremy I, Spira A. Premature mortality measure: Comparison of deaths before 65 and expected years of life lost Revue D'Epidemiologie Et De Sante Publique. 56: 245-252. PMID 18684576 DOI: 10.1016/j.respe.2008.05.025  0.051
2008 Lapostolle A, Lefranc A, Gremy I, Spira A. Premature mortality measure: Comparison of deaths before 65 years of age and expected years of life lost Revue D'Epidemiologie Et De Sante Publique. 56. DOI: 10.1016/j.respe.2008.07.001  0.049
2009 Lapostolle A, Gadegbeku B, Ndiaye A, Amoros E, Chiron M, Spira A, Laumon B. The burden of road traffic accidents in a French Departement: The description of the injuries and recent changes Bmc Public Health. 9. PMID 19825170 DOI: 10.1186/1471-2458-9-386  0.049
2013 Beaudreau SA, Kaci Fairchild J, Spira AP, Lazzeroni LC, O'Hara R. Neuropsychiatric symptoms, apolipoprotein E gene, and risk of progression to cognitive impairment, no dementia and dementia: the Aging, Demographics, and Memory Study (ADAMS). International Journal of Geriatric Psychiatry. 28: 672-80. PMID 22927174 DOI: 10.1002/Gps.3868  0.046
2014 Spira AP, Kaufmann CN, Kasper JD, Ohayon MM, Rebok GW, Skidmore E, Parisi JM, Reynolds CF. Association between insomnia symptoms and functional status in U.S. older adults. The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences. 69: S35-41. PMID 25342821 DOI: 10.1093/Geronb/Gbu116  0.045
2014 Spira AP, An Y, Resnick SM. Self-reported sleep and β-amyloid deposition in older adults-reply. Jama Neurology. 71: 651-2. PMID 24818679 DOI: 10.1001/Jamaneurol.2014.167  0.045
2015 Takayanagi Y, Spira AP, McIntyre RS, Eaton WW. Sex hormone binding globulin and verbal memory in older men. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 23: 253-60. PMID 23800538 DOI: 10.1016/J.Jagp.2013.02.003  0.044
2013 Spira AP, Gamaldo AA, An Y, Wu MN, Simonsick EM, Bilgel M, Zhou Y, Wong DF, Ferrucci L, Resnick SM. Self-reported sleep and β-amyloid deposition in community-dwelling older adults. Jama Neurology. 70: 1537-43. PMID 24145859 DOI: 10.1001/Jamaneurol.2013.4258  0.043
2008 Spira A. Infancy, history and rehabilitation at documenta 12 Journal of Visual Culture. 7: 228-239. DOI: 10.1177/14704129080070020505  0.042
2008 Spira A. Acupuncture: A useful tool for health care in an operational medicine environment Military Medicine. 173: 629-634. PMID 18700595  0.042
2013 Wennberg AM, Canham SL, Smith MT, Spira AP. Optimizing sleep in older adults: treating insomnia. Maturitas. 76: 247-52. PMID 23746664 DOI: 10.1016/J.Maturitas.2013.05.007  0.041
2013 Kaufmann CN, Rutkow L, Spira AP, Mojtabai R. Mental health of protective services workers: results from the national epidemiologic survey on alcohol and related conditions. Disaster Medicine and Public Health Preparedness. 7: 36-45. PMID 23193220 DOI: 10.1001/Dmp.2012.55  0.04
2015 Spira AP. Being mindful of later-life sleep quality and its potential role in prevention. Jama Internal Medicine. 175: 502-3. PMID 25686155 DOI: 10.1001/Jamainternmed.2014.8093  0.04
2015 Demetri GD, von Mehren M, Jones RL, Hensley ML, Schuetze SM, Staddon A, Milhem M, Elias A, Ganjoo K, Tawbi H, Van Tine BA, Spira A, Dean A, Khokhar NZ, Park YC, et al. Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. PMID 26371143 DOI: 10.1200/JCO.2015.62.4734  0.039
2015 Spira AP, Runko VT, Finan PH, Kaufmann CN, Bounds SC, Liu L, Buenaver LF, McCauley LM, Ancoli-Israel S, Smith MT. Circadian rest/activity rhythms in knee osteoarthritis with insomnia: a study of osteoarthritis patients and pain-free controls with insomnia or normal sleep. Chronobiology International. 32: 242-7. PMID 25290041 DOI: 10.3109/07420528.2014.965314  0.039
2014 Hock RS, Lee HB, Bienvenu OJ, Nestadt G, Samuels JF, Parisi JM, Costa PT, Spira AP. Personality and cognitive decline in the Baltimore Epidemiologic Catchment Area follow-up study. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 22: 917-25. PMID 23759291 DOI: 10.1016/J.Jagp.2012.12.217  0.039
2012 Vockelmann C, Spira A, Mecklenbeck FP. Sometimes there is something very wrong with it: The simultaneous double appendicitis Rofo Fortschritte Auf Dem Gebiet Der Rontgenstrahlen Und Der Bildgebenden Verfahren. 184: 580-581. PMID 22473505 DOI: 10.1055/s-0031-1299416  0.038
2016 Kaufmann CN, Spira AP, Depp CA, Mojtabai R. Continuing Versus New Prescriptions for Sedative-Hypnotic Medications: United States, 2005-2012. American Journal of Public Health. e1-e7. PMID 27631754 DOI: 10.2105/Ajph.2016.303382  0.038
2014 Wennberg AM, Gottesman RF, Kaufmann CN, Albert MS, Chen-Edinboro LP, Rebok GW, Kasper JD, Spira AP. Diabetes and cognitive outcomes in a nationally representative sample: the National Health and Aging Trends Study. International Psychogeriatrics / Ipa. 26: 1729-35. PMID 25075535 DOI: 10.1017/S1041610214001380  0.037
2009 Kezirian EJ, Harrison SL, Ancoli-Israel S, Redline S, Ensrud K, Goldberg AN, Claman DM, Spira AP, Stone KL. Behavioral correlates of sleep-disordered breathing in older men. Sleep. 32: 253-61. PMID 19238813  0.037
2014 Spira AP, Chen-Edinboro LP, Wu MN, Yaffe K. Impact of sleep on the risk of cognitive decline and dementia. Current Opinion in Psychiatry. 27: 478-83. PMID 25188896 DOI: 10.1097/Yco.0000000000000106  0.037
2014 Jenkins JL, Levy M, Rutkow L, Spira A. Variables associated with effects on morbidity in older adults following disasters. Plos Currents. 6. PMID 25685623 DOI: 10.1371/currents.dis.0fe970aa16d51cde6a962b7a732e494a  0.036
2014 Spira AP, Yager C, Brandt J, Smith GS, Zhou Y, Mathur A, Kumar A, Braši? JR, Wong DF, Wu MN. Objectively Measured Sleep and β-amyloid Burden in Older Adults: A Pilot Study. Sage Open Medicine. 2. PMID 25621174 DOI: 10.1177/2050312114546520  0.036
2014 Takayanagi Y, Spira AP, Roth KB, Gallo JJ, Eaton WW, Mojtabai R. Accuracy of reports of lifetime mental and physical disorders: results from the Baltimore Epidemiological Catchment Area study. Jama Psychiatry. 71: 273-80. PMID 24402003 DOI: 10.1001/Jamapsychiatry.2013.3579  0.035
2016 Spira AP, Gonzalez CE, Venkatraman VK, Wu MN, Pacheco J, Simonsick EM, Ferrucci L, Resnick SM. Sleep duration and subsequent cortical thinning in cognitively normal older adults Sleep. 39: 1121-1128. DOI: 10.5665/sleep.5768  0.034
2014 Lee SY, Xue QL, Spira AP, Lee HB. Racial and ethnic differences in depressive subtypes and access to mental health care in the United States. Journal of Affective Disorders. 155: 130-7. PMID 24269002 DOI: 10.1016/J.Jad.2013.10.037  0.034
2009 Edwards ER, Spira AP, Barnes DE, Yaffe K. Neuropsychiatric symptoms in mild cognitive impairment: differences by subtype and progression to dementia. International Journal of Geriatric Psychiatry. 24: 716-22. PMID 19140134 DOI: 10.1002/Gps.2187  0.034
2015 Dijkstra AE, Smolonska J, van den Berge M, Wijmenga C, Zanen P, Luinge MA, Platteel M, Lammers JW, Dahlback M, Tosh K, Hiemstra PS, Sterk PJ, Spira A, Vestbo J, Nordestgaard BG, et al. Correction: Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study. Plos One. 10: e0129524. PMID 26024482 DOI: 10.1371/Journal.Pone.0129524  0.034
2015 Karlin BE, Trockel M, Spira AP, Taylor CB, Manber R. National evaluation of the effectiveness of cognitive behavioral therapy for insomnia among older versus younger veterans. International Journal of Geriatric Psychiatry. 30: 308-15. PMID 24890708 DOI: 10.1002/Gps.4143  0.033
2012 Gross AL, Parisi JM, Spira AP, Kueider AM, Ko JY, Saczynski JS, Samus QM, Rebok GW. Memory training interventions for older adults: a meta-analysis. Aging & Mental Health. 16: 722-34. PMID 22423647 DOI: 10.1080/13607863.2012.667783  0.033
2014 Parisi JM, Franchetti MK, Rebok GW, Spira AP, Carlson MC, Willis SL, Gross AL. Depressive symptoms and inductive reasoning performance: findings from the ACTIVE reasoning training intervention. Psychology and Aging. 29: 843-51. PMID 25244465 DOI: 10.1037/A0037670  0.033
1992 Coste J, Paolaggi JB, Spira A. Classification of nonspecific low back pain. I. Psychological involvement in low back pain. A clinical, descriptive approach. Spine. 17: 1028-37. PMID 1411753 DOI: 10.1097/00007632-199209000-00004  0.033
2008 Spira AP, Friedman L, Aulakh JS, Lee T, Sheikh JI, Yesavage JA. Subclinical anxiety symptoms, sleep, and daytime dysfunction in older adults with primary insomnia. Journal of Geriatric Psychiatry and Neurology. 21: 149-53. PMID 18474724 DOI: 10.1177/0891988707317120  0.032
2008 Beaudreau SA, Spira AP, Gray HL, Depp CA, Long J, Rothkopf M, Gallagher-Thompson D. The relationship between objectively measured sleep disturbance and dementia family caregiver distress and burden. Journal of Geriatric Psychiatry and Neurology. 21: 159-65. PMID 18503035 DOI: 10.1177/0891988708316857  0.032
2013 Gamaldo CE, Spira AP, Hock RS, Salas RE, McArthur JC, David PM, Mbeo G, Smith MT. Sleep, function and HIV: a multi-method assessment. Aids and Behavior. 17: 2808-15. PMID 23299876 DOI: 10.1007/S10461-012-0401-0  0.032
2008 Slama R, Boutou O, Ducot B, Spira A. Reproductive life events in the population living in the vicinity of a nuclear waste reprocessing plant Journal of Epidemiology and Community Health. 62: 513-521. PMID 18477750 DOI: 10.1136/jech.2007.061069  0.031
2011 Kaufmann CN, Spira AP, Rae DS, West JC, Mojtabai R. Sleep problems, psychiatric hospitalization, and emergency department use among psychiatric patients with Medicaid. Psychiatric Services (Washington, D.C.). 62: 1101-5. PMID 21885593 DOI: 10.1176/Appi.Ps.62.9.1101  0.031
2015 Takayanagi Y, Spira AP, Bienvenu OJ, Hock RS, Carras MC, Eaton WW, Mojtabai R. Antidepressant use and lifetime history of mental disorders in a community sample: results from the Baltimore Epidemiologic Catchment Area Study. The Journal of Clinical Psychiatry. 76: 40-4. PMID 25188822 DOI: 10.4088/Jcp.13M08824  0.031
2013 Coleman DL, Spira A, Ravid K. Promoting interdisciplinary research in departments of medicine: results from two models at Boston University School of Medicine. Transactions of the American Clinical and Climatological Association. 124: 275-282. PMID 23874035  0.03
2009 Spira A, Lapostolle A. A population health metric for France Bulletin De L'Academie Nationale De Medecine. 193: 1601-1617. PMID 20669639  0.03
2015 Tabuchi M, Lone SR, Liu S, Liu Q, Zhang J, Spira AP, Wu MN. Sleep interacts with aβ to modulate intrinsic neuronal excitability. Current Biology : Cb. 25: 702-12. PMID 25754641 DOI: 10.1016/J.Cub.2015.01.016  0.03
2010 Moreau C, Bouyer J, Ducot B, Spira A, Slama R. When do involuntarily infertile couples choose to seek medical help? Fertility and Sterility. 93: 737-744. PMID 19022434 DOI: 10.1016/j.fertnstert.2008.10.011  0.03
2014 Parisi JM, Xia J, Spira AP, Xue QL, Rieger ML, Rebok GW, Carlson MC. The Association Between Lifestyle Activities and Late-Life Depressive Symptoms. Activities, Adaptation & Aging. 38: 1-10. PMID 24683285 DOI: 10.1080/01924788.2014.878871  0.029
2015 Spira A, Mayrench R, Malah D. Codebook index assignment by an approximate solution of the Traveling Salesman Problem European Signal Processing Conference. 2015.  0.029
2021 Fan X, Johnson BH, Johnston SS, Elangovanraaj N, Kothari P, Spira A, Coplan P, Khanna R. Monthly Trend in Mortality and Length of Stay among COVID-19 Patients: Analysis of a Nationwide Multi-Hospital United States Database. Infection Control and Hospital Epidemiology. 1-8. PMID 33736712 DOI: 10.1017/ice.2021.110  0.029
2002 Kremer H-, Kadota J, Kohno S, Hasegawa Y, Imaizumi K, Sekido Y, Iinuma Y, Kawabe T, Hashimoto N, Shimokata K, Tønnesen P, Burgaud J, Bolliger CT, Gückel C, Engel H, ... ... Spira A, et al. Subject Index Vol. 69, 2002 Respiration. 69: 577-578. DOI: 10.1159/000068064  0.029
1997 Spira A, Gowrishankar M, Halperin ML. Factors contributing to the degree of polyuria in a patient with poorly controlled diabetes mellitus. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. 30: 829-35. PMID 9398128 DOI: 10.1016/S0272-6386(97)90089-5  0.029
2009 Moreau C, Spira A, Bajos N. Trends in contraceptive practices in France: Population effect and social impact Medecine Therapeutique Medecine De La Reproduction, Gynecologie Et Endocrinologie. 11: 338-344. DOI: 10.1684/mte.2009.0263  0.028
2015 Ancoli-Israel S, Martin JL, Blackwell T, Buenaver L, Liu L, Meltzer LJ, Sadeh A, Spira AP, Taylor DJ. The SBSM Guide to Actigraphy Monitoring: Clinical and Research Applications. Behavioral Sleep Medicine. 13: S4-S38. PMID 26273913 DOI: 10.1080/15402002.2015.1046356  0.028
2015 Ancoli-Israel S, Martin JL, Blackwell T, Buenaver L, Liu L, Meltzer LJ, Sadeh A, Spira AP, Taylor DJ. The SBSM Guide to Actigraphy Monitoring: Clinical and Research Applications Behavioral Sleep Medicine. 13: S4-S38. DOI: 10.1080/15402002.2015.1046356  0.028
2016 Ramsey CM, Parisi JM, Rebok GW, Gross A, Tanner EK, Carlson MC, Seeman TE, Roth DL, Spira AP. Attendance and Retention of Older Adults in School-Based Volunteer Activities: The Role of School Climate Journal of Intergenerational Relationships. 14: 27-42. DOI: 10.1080/15350770.2016.1138274  0.028
2014 Jouannet P, Spira A. [Requests for assisted reproduction formulated by same-sex couples consulting physicians in France]. Revue D'ÉPidéMiologie Et De Santé Publique. 62: 268-72. PMID 25043875 DOI: 10.1016/j.respe.2014.05.125  0.027
2016 Diem SJ, Blackwell TL, Stone KL, Yaffe K, Tranah G, Cauley JA, Ancoli-Israel S, Redline S, Spira AP, Hillier TA, Ensrud KE. Measures of Sleep-Wake Patterns and Risk of Mild Cognitive Impairment or Dementia in Older Women. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. PMID 26964485 DOI: 10.1016/J.Jagp.2015.12.002  0.027
2009 Spira AP, Stone K, Beaudreau SA, Ancoli-Israel S, Yaffe K. Anxiety symptoms and objectively measured sleep quality in older women. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 17: 136-43. PMID 19155746 DOI: 10.1097/Jgp.0B013E3181871345  0.026
2012 Friedman L, Spira AP, Hernandez B, Mather C, Sheikh J, Ancoli-Israel S, Yesavage JA, Zeitzer JM. Brief morning light treatment for sleep/wake disturbances in older memory-impaired individuals and their caregivers. Sleep Medicine. 13: 546-9. PMID 22406033 DOI: 10.1016/J.Sleep.2011.11.013  0.026
2011 Yaffe K, Laffan AM, Harrison SL, Redline S, Spira AP, Ensrud KE, Ancoli-Israel S, Stone KL. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. Jama. 306: 613-9. PMID 21828324 DOI: 10.1097/Ogx.0B013E3182439F33  0.026
2012 Ramsey CM, Spira AP, Carlson A, Earley C, Allen R, Lee HB. Restless legs syndrome symptomatology, attitudes and beliefs among treated and untreated individuals. Sleep Medicine. 13: 1226-31. PMID 22939836 DOI: 10.1016/J.Sleep.2012.05.013  0.026
2014 Lee HB, Ramsey CM, Spira AP, Vachon J, Allen R, Munro CA. Comparison of cognitive functioning among individuals with treated restless legs syndrome (RLS), untreated RLS, and no RLS. The Journal of Neuropsychiatry and Clinical Neurosciences. 26: 87-91. PMID 24515680 DOI: 10.1176/Appi.Neuropsych.12120394  0.026
2014 Spira AP, Stone KL, Rebok GW, Punjabi NM, Redline S, Ancoli-Israel S, Yaffe K. Sleep-disordered breathing and functional decline in older women. Journal of the American Geriatrics Society. 62: 2040-6. PMID 25376169 DOI: 10.1111/Jgs.13108  0.025
2015 Gould CE, Rideaux T, Spira AP, Beaudreau SA. Depression and anxiety symptoms in male veterans and non-veterans: the Health and Retirement Study. International Journal of Geriatric Psychiatry. 30: 623-30. PMID 25145943 DOI: 10.1002/Gps.4193  0.025
2013 Rebok GW, Langbaum JB, Jones RN, Gross AL, Parisi JM, Spira AP, Kueider AM, Petras H, Brandt J. Memory training in the ACTIVE study: how much is needed and who benefits? Journal of Aging and Health. 25: 21S-42S. PMID 23103452 DOI: 10.1177/0898264312461937  0.025
2015 Canham SL, Kaufmann CN, Mauro PM, Mojtabai R, Spira AP. Binge drinking and insomnia in middle-aged and older adults: the Health and Retirement Study. International Journal of Geriatric Psychiatry. 30: 284-91. PMID 24798772 DOI: 10.1002/Gps.4139  0.025
2009 Le Goaster C, Ringa V, Spira A. Happy new year 2009! Revue D'Epidemiologie Et De Sante Publique. 57: 1. PMID 19150185 DOI: 10.1016/j.respe.2008.12.001  0.024
2016 Ramsey CM, Spira AP, Parisi JM, Rebok GW. School climate: perceptual differences between students, parents, and school staff School Effectiveness and School Improvement. 1-13. DOI: 10.1080/09243453.2016.1199436  0.023
2012 Spira AP, Rebok GW, Stone KL, Kramer JH, Yaffe K. Depressive symptoms in oldest-old women: risk of mild cognitive impairment and dementia. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 20: 1006-15. PMID 22015706 DOI: 10.1097/Jgp.0B013E318235B611  0.023
2016 Kaufmann CN, Mojtabai R, Hock RS, Thorpe RJ, Canham SL, Chen LY, Wennberg AM, Chen-Edinboro LP, Spira AP. Racial/Ethnic Differences in Insomnia Trajectories Among U.S. Older Adults. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. PMID 27212222 DOI: 10.1016/J.Jagp.2016.02.049  0.022
2012 Yaffe K, Laffan AM, Harrison SL, Redline S, Spira AP, Ensrud KE, Ancoli-Israel S, Stone KL. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women Obstetrical and Gynecological Survey. 67: 34-36. DOI: 10.1097/OGX.0b013e3182439f33  0.022
2012 Lee SY, Franchetti MK, Imanbayev A, Gallo JJ, Spira AP, Lee HB. Non-pharmacological prevention of major depression among community-dwelling older adults: a systematic review of the efficacy of psychotherapy interventions. Archives of Gerontology and Geriatrics. 55: 522-9. PMID 22483200 DOI: 10.1016/J.Archger.2012.03.003  0.022
2012 Beaudreau SA, Spira AP, Stewart A, Kezirian EJ, Lui LY, Ensrud K, Redline S, Ancoli-Israel S, Stone KL. Validation of the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale in older black and white women. Sleep Medicine. 13: 36-42. PMID 22033120 DOI: 10.1016/J.Sleep.2011.04.005  0.02
2016 Spira AP, Gonzalez CE, Venkatraman VK, Wu MN, Pacheco J, Simonsick EM, Ferrucci L, Resnick SM. Sleep Duration and Subsequent Cortical Thinning in Cognitively Normal Older Adults. Sleep. PMID 26951390 DOI: 10.5665/Sleep.5768  0.02
2012 Spira AP, Beaudreau SA, Stone KL, Kezirian EJ, Lui LY, Redline S, Ancoli-Israel S, Ensrud K, Stewart A. Reliability and validity of the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale in older men. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 433-9. PMID 21934125 DOI: 10.1093/Gerona/Glr172  0.02
2012 Spira AP, Covinsky K, Rebok GW, Punjabi NM, Stone KL, Hillier TA, Ensrud KE, Yaffe K. Poor sleep quality and functional decline in older women. Journal of the American Geriatrics Society. 60: 1092-8. PMID 22690985 DOI: 10.1111/J.1532-5415.2012.03968.X  0.019
2015 Fain KM, Rosenberg PB, Pirard S, Bogunovic O, Spira AP. Markers of Impaired Decision Making in Nursing Home Residents: Assessment by Nursing Home Staff in a Population-Based Study. Journal of the American Medical Directors Association. 16: 563-7. PMID 25687926 DOI: 10.1016/j.jamda.2015.01.080  0.019
2011 Yaffe K, Middleton LE, Lui LY, Spira AP, Stone K, Racine C, Ensrud KE, Kramer JH. Mild cognitive impairment, dementia, and their subtypes in oldest old women. Archives of Neurology. 68: 631-6. PMID 21555638 DOI: 10.1001/Archneurol.2011.82  0.018
2015 Spira A, Bégué P, Aurengo A. Comment on: Evolution of multiple sclerosis in France since the beginning of hepatitis B vaccination. Immunologic Research. 62: 1-2. PMID 25690885 DOI: 10.1007/s12026-015-8627-3  0.018
2012 Spira AP, Covinsky K, Rebok GW, Stone KL, Redline S, Yaffe K. Objectively measured sleep quality and nursing home placement in older women. Journal of the American Geriatrics Society. 60: 1237-43. PMID 22702839 DOI: 10.1111/J.1532-5415.2012.04044.X  0.017
2012 Moatti JP, Spira A, Manoux AS, Thiebaut R. [Recognizing the specificity of public health research to increase its scientific, health and social impact]. Santé Publique (Vandoeuvre-LèS-Nancy, France). 24: 383-5. PMID 23472980  0.016
2014 Wennberg A, Kueider A, Spira A, Adams G, Rager R, Rebok G. Online Attention Training for Older Adults. The International Journal of Cognitive Technology : the Official Journal of the Practical Memory Institute. 19: 13-21. PMID 27057152  0.016
2013 Rutkow L, Vernick JS, Spira AP, Barnett DJ. Using the law to promote the mental health of older adults during disasters. The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics. 41: 80-3. PMID 23590748 DOI: 10.1111/Jlme.12046  0.015
2011 Spira A. Property of data and fertility decline Revue D'Epidemiologie Et De Sante Publique. 59: 211-212. PMID 21784591 DOI: 10.1016/j.respe.2011.07.001  0.015
2018 Spira A, Coleman D. Impact of an Interdisciplinary Computational Research Section in a Department of Medicine: an Eight-Year Perspective. The American Journal of Medicine. PMID 29601802 DOI: 10.1016/J.Amjmed.2018.03.008  0.013
2013 Lohman MC, Rebok GW, Spira AP, Parisi JM, Gross AL, Kueider AM. Depressive symptoms and memory performance among older adults: results from the ACTIVE memory training intervention. Journal of Aging and Health. 25: 209S-29S. PMID 23006426 DOI: 10.1177/0898264312460573  0.013
2010 Spira AP, Friedman L, Beaudreau SA, Ancoli-Israel S, Hernandez B, Sheikh J, Yesavage J. Sleep and physical functioning in family caregivers of older adults with memory impairment. International Psychogeriatrics / Ipa. 22: 306-11. PMID 19943990 DOI: 10.1017/S1041610209991153  0.013
2013 Kaufmann CN, Canham SL, Mojtabai R, Gum AM, Dautovich ND, Kohn R, Spira AP. Insomnia and health services utilization in middle-aged and older adults: results from the Health and Retirement Study. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 1512-7. PMID 23666943 DOI: 10.1093/Gerona/Glt050  0.012
2011 Spira A. There is room for different languages in public health journals Revue D'Epidemiologie Et De Sante Publique. 59: 1-2. PMID 21251778 DOI: 10.1016/j.respe.2010.11.001  0.01
2010 Rebok GW, Parisi JM, Gross AL, Spira AP. Assessment of Cognitive Training Handbook of Assessment in Clinical Gerontology. 211-228. DOI: 10.1016/B978-0-12-374961-1.10008-9  0.01
2009 Spira AM. Ebola hemorrhagic fever and Marburg hemorrhagic fever Infections in Medicine. 26: 89-93.  0.01
2008 Spira AM, Arguin PM. Diving and Marine Medicine Travel Medicine. 405-412. DOI: 10.1016/B978-0-323-03453-1.10040-9  0.01
2002 Kremer H-, Kadota J, Kohno S, Hasegawa Y, Imaizumi K, Sekido Y, Iinuma Y, Kawabe T, Hashimoto N, Shimokata K, Tønnesen P, Burgaud J, Bolliger CT, Gückel C, Engel H, ... ... Spira A, et al. Contents Vol. 69, 2002 Respiration. 69: 579-583. DOI: 10.1159/000068065  0.01
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