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Marc R. Freeman, Ph.D. - Publications

Affiliations: 
Neurobiology University of Massachusetts Medical School, Worcester, MA, United States 
 Oregon Health and Science University, Portland, OR 
Area:
Glia neurobiology and neurodegeneration
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76 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Coutinho-Budd J, Freeman MR, Ackerman S. Glial Regulation of Circuit Wiring, Firing, and Expiring in the Central Nervous System. Cold Spring Harbor Perspectives in Biology. PMID 38565270 DOI: 10.1101/cshperspect.a041347  0.714
2022 Lassetter AP, Corty MM, Barria R, Sheehan AE, Hill JQ, Aicher SA, Fox AN, Freeman MR. Glial TGFβ activity promotes neuron survival in peripheral nerves. The Journal of Cell Biology. 222. PMID 36399182 DOI: 10.1083/jcb.202111053  0.772
2022 Corty MM, Hulegaard AL, Hill JQ, Sheehan AE, Aicher SA, Freeman MR. Discoidin domain receptor regulates ensheathment, survival, and caliber of peripheral axons. Development (Cambridge, England). PMID 36355066 DOI: 10.1242/dev.200636  0.417
2021 Sambashivan S, Freeman MR. SARM1 signaling mechanisms in the injured nervous system. Current Opinion in Neurobiology. 69: 247-255. PMID 34175654 DOI: 10.1016/j.conb.2021.05.004  0.371
2021 Lin TH, Bis-Brewer DM, Sheehan AE, Townsend LN, Maddison DC, Züchner S, Smith GA, Freeman MR. TSG101 negatively regulates mitochondrial biogenesis in axons. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33972422 DOI: 10.1073/pnas.2018770118  0.717
2021 Peters OM, Weiss A, Metterville J, Song L, Logan R, Smith GA, Schwarzschild MA, Mueller C, Brown RH, Freeman M. Genetic diversity of axon degenerative mechanisms in models of Parkinson's disease. Neurobiology of Disease. 105368. PMID 33892050 DOI: 10.1016/j.nbd.2021.105368  0.804
2021 Ackerman SD, Perez-Catalan NA, Freeman MR, Doe CQ. Astrocytes close a motor circuit critical period. Nature. PMID 33828296 DOI: 10.1038/s41586-021-03441-2  0.742
2020 Hsu JM, Kang Y, Corty MM, Mathieson D, Peters OM, Freeman MR. Injury-Induced Inhibition of Bystander Neurons Requires dSarm and Signaling from Glia. Neuron. PMID 33296670 DOI: 10.1016/j.neuron.2020.11.012  0.784
2020 Ma Z, Freeman MR. TrpML-mediated astrocyte microdomain Ca transients regulate astrocyte-tracheal interactions. Elife. 9. PMID 33284108 DOI: 10.7554/eLife.58952  0.573
2020 Chen J, Poskanzer KE, Freeman MR, Monk KR. Live-imaging of astrocyte morphogenesis and function in zebrafish neural circuits. Nature Neuroscience. PMID 32895565 DOI: 10.1038/S41593-020-0703-X  0.358
2019 Gu P, Gong J, Shang Y, Wang F, Ruppell KT, Ma Z, Sheehan AE, Freeman MR, Xiang Y. Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1. Current Biology : Cb. PMID 31735672 DOI: 10.1016/J.Cub.2019.09.070  0.605
2019 Kant S, Craige SM, Chen K, Reif MM, Learnard H, Kelly M, Caliz AD, Tran KV, Ramo K, Peters OM, Freeman M, Davis RJ, Keaney JF. Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis. Nature Communications. 10: 4223. PMID 31530804 DOI: 10.1038/S41467-019-11982-4  0.709
2019 Smith GA, Lin TH, Sheehan AE, Van der Goes van Naters W, Neukomm LJ, Graves HK, Bis-Brewer DM, Züchner S, Freeman MR. Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation. Neuron. PMID 31101394 DOI: 10.1016/J.Neuron.2019.04.017  0.795
2018 Cho S, Muthukumar AK, Stork T, Coutinho-Budd JC, Freeman MR. Focal adhesion molecules regulate astrocyte morphology and glutamate transporters to suppress seizure-like behavior. Proceedings of the National Academy of Sciences of the United States of America. PMID 30327343 DOI: 10.1073/Pnas.1800830115  0.758
2018 Peters OM, Lewis EA, Osterloh JM, Weiss A, Salameh JS, Metterville J, Brown RH, Freeman MR. Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis. Human Molecular Genetics. PMID 30010873 DOI: 10.1093/Hmg/Ddy260  0.804
2018 Farley JE, Burdett TC, Barria R, Neukomm LJ, Kenna KP, Landers JE, Freeman MR. Transcription factor Pebbled/RREB1 regulates injury-induced axon degeneration. Proceedings of the National Academy of Sciences of the United States of America. PMID 29295933 DOI: 10.1073/Pnas.1715837115  0.553
2017 Coutinho-Budd JC, Sheehan AE, Freeman MR. The secreted neurotrophin Spätzle 3 promotes glial morphogenesis and supports neuronal survival and function. Genes & Development. PMID 29138279 DOI: 10.1101/Gad.305888.117  0.791
2017 Neukomm LJ, Burdett TC, Seeds AM, Hampel S, Coutinho-Budd JC, Farley JE, Wong J, Karadeniz YB, Osterloh JM, Sheehan AE, Freeman MR. Axon Death Pathways Converge on Axundead to Promote Functional and Structural Axon Disassembly. Neuron. 95: 78-91.e5. PMID 28683272 DOI: 10.1016/J.Neuron.2017.06.031  0.813
2017 Lu TY, MacDonald JM, Neukomm LJ, Sheehan AE, Bradshaw R, Logan MA, Freeman MR. Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling. Nature Communications. 8: 14355. PMID 28165006 DOI: 10.1038/Ncomms14355  0.734
2016 Ma Z, Stork T, Bergles DE, Freeman MR. Neuromodulators signal through astrocytes to alter neural circuit activity and behaviour. Nature. PMID 27828941 DOI: 10.1038/Nature20145  0.65
2016 He J, Zhou R, Wu Z, Carrasco MA, Kurshan PT, Farley JE, Simon DJ, Wang G, Han B, Hao J, Heller E, Freeman MR, Shen K, Maniatis T, Tessier-Lavigne M, et al. Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species. Proceedings of the National Academy of Sciences of the United States of America. PMID 27162329 DOI: 10.1073/Pnas.1605707113  0.464
2016 Francis MM, Freeman MR. Dendrites actively restrain axon outgrowth and regeneration. Proceedings of the National Academy of Sciences of the United States of America. PMID 27147603 DOI: 10.1073/Pnas.1605215113  0.525
2016 Henninger N, Bouley J, Sikoglu EM, An J, Moore CM, King JA, Bowser R, Freeman MR, Brown RH. Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lacking Sarm1. Brain : a Journal of Neurology. PMID 26912636 DOI: 10.1093/Brain/Aww001  0.653
2015 Farley JE, Freeman MR. Letting Go of JuNK by Disassembly of Adhesive Complexes. Neuron. 88: 848-50. PMID 26637791 DOI: 10.1016/J.Neuron.2015.11.015  0.401
2015 Sreedharan J, Neukomm LJ, Brown RH, Freeman MR. Age-Dependent TDP-43-Mediated Motor Neuron Degeneration Requires GSK3, hat-trick, and xmas-2. Current Biology : Cb. PMID 26234214 DOI: 10.1016/J.Cub.2015.06.045  0.531
2015 Sauer VT, Diao Z, Freeman MR, Hiebert WK. Wavelength-division multiplexing of nano-optomechanical doubly clamped beam systems. Optics Letters. 40: 1948-51. PMID 25927755 DOI: 10.1364/Ol.40.001948  0.485
2015 Freeman MR. Drosophila Central Nervous System Glia. Cold Spring Harbor Perspectives in Biology. PMID 25722465 DOI: 10.1101/Cshperspect.A020552  0.437
2014 Doherty J, Sheehan AE, Bradshaw R, Fox AN, Lu TY, Freeman MR. PI3K signaling and Stat92E converge to modulate glial responsiveness to axonal injury. Plos Biology. 12: e1001985. PMID 25369313 DOI: 10.1371/Journal.Pbio.1001985  0.436
2014 Muthukumar AK, Stork T, Freeman MR. Activity-dependent regulation of astrocyte GAT levels during synaptogenesis. Nature Neuroscience. 17: 1340-50. PMID 25151265 DOI: 10.1038/Nn.3791  0.322
2014 Lu TY, Doherty J, Freeman MR. DRK/DOS/SOS converge with Crk/Mbc/dCed-12 to activate Rac1 during glial engulfment of axonal debris. Proceedings of the National Academy of Sciences of the United States of America. 111: 12544-9. PMID 25099352 DOI: 10.1073/Pnas.1403450111  0.507
2014 Burdett TC, Freeman MR. Neuroscience. Astrocytes eyeball axonal mitochondria. Science (New York, N.Y.). 345: 385-6. PMID 25061193 DOI: 10.1126/Science.1258295  0.446
2014 Stork T, Sheehan A, Tasdemir-Yilmaz OE, Freeman MR. Neuron-glia interactions through the Heartless FGF receptor signaling pathway mediate morphogenesis of Drosophila astrocytes. Neuron. 83: 388-403. PMID 25033182 DOI: 10.1016/J.Neuron.2014.06.026  0.424
2014 Neukomm LJ, Burdett TC, Gonzalez MA, Züchner S, Freeman MR. Rapid in vivo forward genetic approach for identifying axon death genes in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 111: 9965-70. PMID 24958874 DOI: 10.1073/Pnas.1406230111  0.526
2014 Freeman MR. Signaling mechanisms regulating Wallerian degeneration. Current Opinion in Neurobiology. 27: 224-31. PMID 24907513 DOI: 10.1016/J.Conb.2014.05.001  0.512
2014 Neukomm LJ, Freeman MR. Diverse cellular and molecular modes of axon degeneration. Trends in Cell Biology. 24: 515-23. PMID 24780172 DOI: 10.1016/J.Tcb.2014.04.003  0.49
2014 Rooney TM, Freeman MR. Drosophila models of neuronal injury. Ilar Journal / National Research Council, Institute of Laboratory Animal Resources. 54: 291-5. PMID 24615442 DOI: 10.1093/Ilar/Ilt057  0.473
2014 Kerr KS, Fuentes-Medel Y, Brewer C, Barria R, Ashley J, Abruzzi KC, Sheehan A, Tasdemir-Yilmaz OE, Freeman MR, Budnik V. Glial wingless/Wnt regulates glutamate receptor clustering and synaptic physiology at the Drosophila neuromuscular junction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 2910-20. PMID 24553932 DOI: 10.1523/Jneurosci.3714-13.2014  0.772
2014 Tasdemir-Yilmaz OE, Freeman MR. Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons. Genes & Development. 28: 20-33. PMID 24361692 DOI: 10.1101/Gad.229518.113  0.462
2013 Corty MM, Freeman MR. Cell biology in neuroscience: Architects in neural circuit design: glia control neuron numbers and connectivity. The Journal of Cell Biology. 203: 395-405. PMID 24217617 DOI: 10.1083/Jcb.201306099  0.393
2013 Freeman MR, Rowitch DH. Evolving concepts of gliogenesis: a look way back and ahead to the next 25 years. Neuron. 80: 613-23. PMID 24183014 DOI: 10.1016/J.Neuron.2013.10.034  0.4
2013 Milde S, Fox AN, Freeman MR, Coleman MP. Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo. Scientific Reports. 3: 2567. PMID 23995269 DOI: 10.1038/Srep02567  0.514
2013 Coutinho-Budd J, Freeman MR. Probing the enigma: unraveling glial cell biology in invertebrates. Current Opinion in Neurobiology. 23: 1073-9. PMID 23896311 DOI: 10.1016/J.Conb.2013.07.002  0.759
2013 Macdonald JM, Doherty J, Hackett R, Freeman MR. The c-Jun kinase signaling cascade promotes glial engulfment activity through activation of draper and phagocytic function. Cell Death and Differentiation. 20: 1140-8. PMID 23618811 DOI: 10.1038/Cdd.2013.30  0.476
2012 Gonzalez MA, Van Booven D, Hulme W, Ulloa RH, Lebrigio RF, Osterloh J, Logan M, Freeman M, Zuchner S. Whole Genome Sequencing and a New Bioinformatics Platform Allow for Rapid Gene Identification in D. melanogaster EMS Screens. Biology. 1: 766-77. PMID 24832518 DOI: 10.3390/Biology1030766  0.641
2012 Svitelskiy O, Sauer V, Vick D, Cheng KM, Liu N, Freeman MR, Hiebert WK. Nanoelectromechanical devices in a fluidic environment. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. 85: 056313. PMID 23004868 DOI: 10.1103/Physreve.85.056313  0.494
2012 Fuentes-Medel Y, Ashley J, Barria R, Maloney R, Freeman M, Budnik V. Integration of a retrograde signal during synapse formation by glia-secreted TGF-β ligand. Current Biology : Cb. 22: 1831-8. PMID 22959350 DOI: 10.1016/J.Cub.2012.07.063  0.382
2012 Wishart TM, Rooney TM, Lamont DJ, Wright AK, Morton AJ, Jackson M, Freeman MR, Gillingwater TH. Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo. Plos Genetics. 8: e1002936. PMID 22952455 DOI: 10.1371/Journal.Pgen.1002936  0.487
2012 Ziegenfuss JS, Doherty J, Freeman MR. Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy. Nature Neuroscience. 15: 979-87. PMID 22706267 DOI: 10.1038/Nn.3135  0.831
2012 Osterloh JM, Yang J, Rooney TM, Fox AN, Adalbert R, Powell EH, Sheehan AE, Avery MA, Hackett R, Logan MA, MacDonald JM, Ziegenfuss JS, Milde S, Hou YJ, Nathan C, ... ... Freeman MR, et al. dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science (New York, N.Y.). 337: 481-4. PMID 22678360 DOI: 10.1126/Science.1223899  0.813
2012 Logan MA, Hackett R, Doherty J, Sheehan A, Speese SD, Freeman MR. Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury. Nature Neuroscience. 15: 722-30. PMID 22426252 DOI: 10.1038/Nn.3066  0.725
2012 Avery MA, Rooney TM, Pandya JD, Wishart TM, Gillingwater TH, Geddes JW, Sullivan PG, Freeman MR. WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering. Current Biology : Cb. 22: 596-600. PMID 22425157 DOI: 10.1016/J.Cub.2012.02.043  0.425
2012 Stork T, Bernardos R, Freeman MR. Analysis of glial cell development and function in Drosophila. Cold Spring Harbor Protocols. 2012: 1-17. PMID 22194269 DOI: 10.1101/Pdb.Top067587  0.388
2011 Nikolic-Jaric M, Ferrier GA, Thomson DJ, Bridges GE, Freeman MR. Dielectric response of particles in flowing media: the effect of shear-induced rotation on the variation in particle polarizability. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. 84: 011922. PMID 21867228 DOI: 10.1103/Physreve.84.011922  0.487
2010 Freeman MR. Specification and morphogenesis of astrocytes. Science (New York, N.Y.). 330: 774-8. PMID 21051628 DOI: 10.1126/Science.1190928  0.377
2010 McPhee CK, Logan MA, Freeman MR, Baehrecke EH. Activation of autophagy during cell death requires the engulfment receptor Draper. Nature. 465: 1093-6. PMID 20577216 DOI: 10.1038/Nature09127  0.636
2010 Coleman MP, Freeman MR. Wallerian degeneration, wld(s), and nmnat. Annual Review of Neuroscience. 33: 245-67. PMID 20345246 DOI: 10.1146/Annurev-Neuro-060909-153248  0.498
2009 Svitelskiy O, Sauer V, Liu N, Cheng KM, Finley E, Freeman MR, Hiebert WK. Pressurized fluid damping of nanoelectromechanical systems. Physical Review Letters. 103: 244501. PMID 20366202 DOI: 10.1103/Physrevlett.103.244501  0.495
2009 Osterloh JM, Freeman MR. Neuronal death or dismemberment mediated by Sox14. Nature Neuroscience. 12: 1479-80. PMID 19935724 DOI: 10.1038/Nn1209-1479  0.504
2009 Ferrier GA, Romanuik SF, Thomson DJ, Bridges GE, Freeman MR. A microwave interferometric system for simultaneous actuation and detection of single biological cells. Lab On a Chip. 9: 3406-12. PMID 19904408 DOI: 10.1039/B908974H  0.517
2009 Fuentes-Medel Y, Logan MA, Ashley J, Ataman B, Budnik V, Freeman MR. Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris. Plos Biology. 7: e1000184. PMID 19707574 DOI: 10.1371/Journal.Pbio.1000184  0.627
2009 Doherty J, Logan MA, Ta?demir OE, Freeman MR. Ensheathing glia function as phagocytes in the adult Drosophila brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 4768-81. PMID 19369546 DOI: 10.1523/Jneurosci.5951-08.2009  0.715
2009 Avery MA, Sheehan AE, Kerr KS, Wang J, Freeman MR. Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration. The Journal of Cell Biology. 184: 501-13. PMID 19237597 DOI: 10.1083/Jcb.200808042  0.791
2008 Ziegenfuss JS, Biswas R, Avery MA, Hong K, Sheehan AE, Yeung YG, Stanley ER, Freeman MR. Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling. Nature. 453: 935-9. PMID 18432193 DOI: 10.1038/Nature06901  0.813
2007 Freeman MR. A look inside. Neuron Glia Biology. 3: 1-3. PMID 18634573 DOI: 10.1017/S1740925X07000646  0.413
2007 Logan MA, Freeman MR. The scoop on the fly brain: glial engulfment functions in Drosophila. Neuron Glia Biology. 3: 63-74. PMID 18172512 DOI: 10.1017/S1740925X07000646  0.653
2007 Emery P, Freeman MR. Glia got rhythm. Neuron. 55: 337-9. PMID 17678846 DOI: 10.1016/J.Neuron.2007.07.014  0.359
2006 MacDonald JM, Beach MG, Porpiglia E, Sheehan AE, Watts RJ, Freeman MR. The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons. Neuron. 50: 869-81. PMID 16772169 DOI: 10.1016/J.Neuron.2006.04.028  0.533
2006 Freeman MR. Sculpting the nervous system: glial control of neuronal development. Current Opinion in Neurobiology. 16: 119-25. PMID 16387489 DOI: 10.1016/J.Conb.2005.12.004  0.49
2006 Freeman MR, Doherty J. Glial cell biology in Drosophila and vertebrates. Trends in Neurosciences. 29: 82-90. PMID 16377000 DOI: 10.1016/J.Tins.2005.12.002  0.412
2005 Freeman MR. Glial (and neuronal) cells missing. Neuron. 48: 163-5. PMID 16242394 DOI: 10.1016/J.Neuron.2005.10.002  0.394
2005 Freeman MR. Glial control of synaptogenesis. Cell. 120: 292-3. PMID 15707887 DOI: 10.1016/J.Cell.2005.01.021  0.371
2003 Freeman MR, Delrow J, Kim J, Johnson E, Doe CQ. Unwrapping glial biology: Gcm target genes regulating glial development, diversification, and function. Neuron. 38: 567-80. PMID 12765609 DOI: 10.1016/S0896-6273(03)00289-7  0.631
2001 Freeman MR, Doe CQ. Moving muscle. Jeb signaling in Drosophila. Developmental Cell. 1: 587-8. PMID 11709176 DOI: 10.1016/S1534-5807(01)00080-6  0.569
2001 Freeman MR, Doe CQ. Asymmetric Prospero localization is required to generate mixed neuronal/glial lineages in the Drosophila CNS. Development (Cambridge, England). 128: 4103-12. PMID 11641232  0.555
1999 Freeman MR, Dobritsa A, Gaines P, Segraves WA, Carlson JR. The dare gene: steroid hormone production, olfactory behavior, and neural degeneration in Drosophila. Development (Cambridge, England). 126: 4591-602. PMID 10498693  0.687
1999 Clyne PJ, Warr CG, Freeman MR, Lessing D, Kim J, Carlson JR. A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila. Neuron. 22: 327-38. PMID 10069338 DOI: 10.1016/S0896-6273(00)81093-4  0.733
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