George F. Koob - Publications

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Neurobiology of emotion
Website:
https://www.scripps.edu/research/faculty/koob

500 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Hastings LE, Frye EV, Carlson ER, Chuong V, Matthews AN, Koob GF, Vendruscolo LF, Marchette RCN. Cold nociception as a measure of hyperalgesia during spontaneous heroin withdrawal in mice. Pharmacology, Biochemistry, and Behavior. 235: 173694. PMID 38128767 DOI: 10.1016/j.pbb.2023.173694  0.79
2023 Leggio L, Leko A, Gregory-Flores A, Marchette R, Gomez J, Vendruscolo J, Repunte-Canonigo V, Chuong V, Deschaine S, Whiting K, Jackson S, Cornejo M, Perello M, You ZB, Eckhaus M, ... ... Koob G, et al. Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet. Research Square. PMID 37886546 DOI: 10.21203/rs.3.rs-3236045/v1  0.791
2023 Richardson RS, Sulima A, Rice KC, Kucharczk JA, Janda KD, Nisbett KE, Koob GF, Vendruscolo LF, Leggio L. Pharmacological GHSR (ghrelin receptor) blockade reduces alcohol binge-like drinking in male and female mice. Neuropharmacology. 109643. PMID 37369277 DOI: 10.1016/j.neuropharm.2023.109643  0.453
2023 Chuong V, Farokhnia M, Khom S, Pince CL, Elvig SK, Vlkolinsky R, Marchette RC, Koob GF, Roberto M, Vendruscolo LF, Leggio L. The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission. Jci Insight. PMID 37192005 DOI: 10.1172/jci.insight.170671  0.811
2022 Farokhnia M, Rentsch CT, Chuong V, McGinn MA, Elvig SK, Douglass EA, Gonzalez LA, Sanfilippo JE, Marchette RCN, Tunstall BJ, Fiellin DA, Koob GF, Justice AC, Leggio L, Vendruscolo LF. Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent and human studies. Molecular Psychiatry. PMID 36123420 DOI: 10.1038/s41380-022-01736-y  0.804
2022 Aldridge GM, Zarin TA, Brandner AJ, George O, Gilpin NW, Repunte-Canonigo V, Sanna PP, Koob GF, Vendruscolo LF, Schmeichel BE. Effects of single and dual hypocretin-receptor blockade or knockdown of hypocretin projections to the central amygdala on alcohol drinking in dependent male rats. Addiction Neuroscience. 3. PMID 35965958 DOI: 10.1016/j.addicn.2022.100028  0.783
2022 Carmack SA, Vendruscolo JCM, Adrienne McGinn M, Miranda-Barrientos J, Repunte-Canonigo V, Bosse GD, Mercatelli D, Giorgi FM, Fu Y, Hinrich AJ, Jodelka FM, Ling K, Messing RO, Peterson RT, Rigo F, ... ... Koob GF, et al. Corticosteroid sensitization drives opioid addiction. Molecular Psychiatry. PMID 35296810 DOI: 10.1038/s41380-022-01501-1  0.639
2021 O'Dell LE, Koob GF, Nazarian A. Vulnerability to substance abuse: A consideration of allostatic loading factors. Neuropharmacology. 108767. PMID 34454910 DOI: 10.1016/j.neuropharm.2021.108767  0.579
2021 McGinn MA, Tunstall BJ, Schlosburg JE, Gregory-Flores A, George O, de Guglielmo G, Mason BJ, Hunt HJ, Koob GF, Vendruscolo LF. Glucocorticoid receptor modulators decrease alcohol self-administration in male rats. Neuropharmacology. 108510. PMID 33647278 DOI: 10.1016/j.neuropharm.2021.108510  0.811
2021 Cunningham JI, Todtenkopf MS, Dean RL, Azar MR, Koob GF, Deaver DR, Eyerman DJ. Samidorphan, an opioid receptor antagonist, attenuates drug-induced increases in extracellular dopamine concentrations and drug self-administration in male Wistar rats. Pharmacology, Biochemistry, and Behavior. 173157. PMID 33647274 DOI: 10.1016/j.pbb.2021.173157  0.35
2020 Tolomeo S, Macfarlane JA, Baldacchino A, Koob GF, Steele JD. Alcohol Binge Drinking: Negative and Positive Valence System Abnormalities. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. PMID 33279457 DOI: 10.1016/j.bpsc.2020.09.010  0.312
2020 Moussawi K, Ortiz MM, Gantz SC, Tunstall BJ, Marchette RCN, Bonci A, Koob GF, Vendruscolo LF. Fentanyl vapor self-administration model in mice to study opioid addiction. Science Advances. 6: eabc0413. PMID 32821843 DOI: 10.1126/Sciadv.Abc0413  0.385
2020 Voon V, Grodin E, Mandali A, Morris L, Doñamayor N, Weidacker K, Kwako L, Goldman D, Koob GF, Momenan R. Addictions NeuroImaging Assessment (ANIA): Towards an integrative framework for alcohol use disorder. Neuroscience and Biobehavioral Reviews. 113: 492-506. PMID 32298710 DOI: 10.1016/J.Neubiorev.2020.04.004  0.332
2020 Ray LA, Grodin EN, Leggio L, Bechtholt AJ, Becker H, Feldstein Ewing SW, Jentsch JD, King AC, Mason BJ, O'Malley S, MacKillop J, Heilig M, Koob GF. The future of translational research on alcohol use disorder. Addiction Biology. e12903. PMID 32286721 DOI: 10.1111/Adb.12903  0.577
2020 Guillot A, Koob GF, Gao B. Reply to Brewer: Liver-targeted ALDH2 inhibition may reduce alcohol-seeking behaviors with limited side effects. Proceedings of the National Academy of Sciences of the United States of America. PMID 32127485 DOI: 10.1073/pnas.2001049117  0.336
2020 Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, ... ... Koob GF, et al. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. Jci Insight. 5. PMID 32051339 DOI: 10.1172/Jci.Insight.131277  0.792
2019 Guillot A, Ren T, Jourdan T, Pawlosky RJ, Han E, Kim SJ, Zhang L, Koob GF, Gao B. Targeting liver aldehyde dehydrogenase-2 prevents heavy but not moderate alcohol drinking. Proceedings of the National Academy of Sciences of the United States of America. PMID 31792171 DOI: 10.1073/pnas.1908137116  0.328
2019 Lee JS, Mukhopadhyay P, Matyas C, Trojnar E, Paloczi J, Yang YR, Blank BA, Savage C, Sorokin AV, Mehta NN, Vendruscolo JCM, Koob GF, Vendruscolo LF, Pacher P, Lohoff FW. PCSK9 inhibition as a novel therapeutic target for alcoholic liver disease. Scientific Reports. 9: 17167. PMID 31748600 DOI: 10.1038/s41598-019-53603-6  0.314
2019 Tunstall BJ, Lorrai I, McConnell SA, Gazo KL, Zallar LJ, de Guglielmo G, Hoang I, Haass-Koffler CL, Repunte-Canonigo V, Koob GF, Vendruscolo LF, Sanna PP. Probenecid Reduces Alcohol Drinking in Rodents. Is Pannexin1 a Novel Therapeutic Target for Alcohol Use Disorder? Alcohol and Alcoholism (Oxford, Oxfordshire). 54: 497-502. PMID 31535696 DOI: 10.1093/alcalc/agz054  0.677
2019 Zorrilla EP, Koob GF. Corrigendum: Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency. Frontiers in Behavioral Neuroscience. 13: 188. PMID 31501652 DOI: 10.3389/fnbeh.2019.00188  0.667
2019 Koob GF. Neurobiology of Opioid Addiction: Opponent Process, Hyperkatifeia, and Negative Reinforcement. Biological Psychiatry. PMID 31400808 DOI: 10.1016/j.biopsych.2019.05.023  0.375
2019 Zorrilla EP, Koob GF. Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency. Frontiers in Behavioral Neuroscience. 13: 136. PMID 31293401 DOI: 10.3389/fnbeh.2019.00136  0.718
2019 Tunstall BJ, Kirson D, Zallar LJ, McConnell SA, Vendruscolo JCM, Ho CP, Oleata CS, Khom S, Manning M, Lee MR, Leggio L, Koob GF, Roberto M, Vendruscolo LF. Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala. Plos Biology. 17: e2006421. PMID 30990816 DOI: 10.1371/Journal.Pbio.2006421  0.4
2019 Carmack SA, Keeley RJ, Vendruscolo JC, Lowery-Gionta EG, Lu H, Koob GF, Stein EA, Vendruscolo LF. Heroin addiction engages negative emotional learning brain circuits in rats. The Journal of Clinical Investigation. 130. PMID 30913040 DOI: 10.1172/Jci125534  0.361
2019 de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nature Communications. 10: 1238. PMID 30886240 DOI: 10.1038/S41467-019-09183-0  0.812
2019 Towers EB, Tunstall BJ, McCracken MM, Vendruscolo LF, Koob GF. Male and female mice develop escalation of heroin intake and dependence following extended access. Neuropharmacology. PMID 30880124 DOI: 10.1016/j.neuropharm.2019.03.019  0.311
2019 Tyler RE, Kim SW, Guo M, Joo Jang Y, Damadzic R, Stodden T, Vendruscolo LF, Koob GF, Wang GJ, Wiers CE, Volkow ND. Detecting neuroinflammation in brain following chronic alcohol exposure in rats: a comparison between in vivo and in vitro TSPO radioligand binding. The European Journal of Neuroscience. PMID 30803059 DOI: 10.1111/ejn.14392  0.353
2019 Uhl GR, Koob GF, Cable J. The neurobiology of addiction. Annals of the New York Academy of Sciences. PMID 30644552 DOI: 10.1111/nyas.13989  0.356
2019 Lohoff F, Sorcher J, Rosen A, Mauro K, Vendruscolo L, Koob G, Gao G, Muench C, Kaminsky Z. Epigenome-Wide Association Analysis And Replication Implicates Deregulation Of Pcsk9 In Alcohol Use Disorder European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2017.08.247  0.317
2019 Koob G. 211. Role of the Central Nucleus of the Amygdala in the Dark Side of Drug Addiction: A Neuroendocrine Connection Biological Psychiatry. 85: S87-S88. DOI: 10.1016/j.biopsych.2019.03.225  0.327
2018 Frantz K, Roberto M, Mason B, Koob GF, Volkow N, Rodriguez de Fonseca F. Larry Parsons: Researcher, mentor, and friend. Addiction Biology. 23: 1204-1206. PMID 30485629 DOI: 10.1111/Adb.12686  0.633
2018 Zallar LJ, Beurmann S, Tunstall BJ, Fraser CM, Koob GF, Vendruscolo LF, Leggio L. Ghrelin receptor deletion reduces binge-like alcohol drinking in rats. Journal of Neuroendocrinology. e12663. PMID 30456835 DOI: 10.1111/Jne.12663  0.379
2018 Du C, Volkow ND, You J, Park K, Allen CP, Koob GF, Pan Y. Cocaine-induced ischemia in prefrontal cortex is associated with escalation of cocaine intake in rodents. Molecular Psychiatry. PMID 30283033 DOI: 10.1038/S41380-018-0261-8  0.373
2018 Koob GF, Schulkin J. Addiction and Stress: An Allostatic View. Neuroscience and Biobehavioral Reviews. PMID 30227143 DOI: 10.1016/J.Neubiorev.2018.09.008  0.334
2018 Somkuwar SS, Quach LW, Quigley JA, Purohit DC, Fannon MJ, Koob GF, Mandyam CD. Ethanol Reinforcement Elicits Novel Response Inhibition Behavior in a Rat Model of Ethanol Dependence. Brain Sciences. 8. PMID 29949891 DOI: 10.3390/Brainsci8070119  0.682
2018 Pelloux Y, Degoulet M, Tiran-Cappello A, Cohen C, Lardeux S, George O, Koob GF, Ahmed SH, Baunez C. Subthalamic nucleus high frequency stimulation prevents and reverses escalated cocaine use. Molecular Psychiatry. PMID 29880881 DOI: 10.1038/S41380-018-0080-Y  0.804
2018 Kim SW, Wiers CE, Tyler R, Shokri-Kojori E, Jang YJ, Zehra A, Freeman C, Ramirez V, Lindgren E, Miller G, Cabrera EA, Stodden T, Guo M, Demiral ŞB, Diazgranados N, ... ... Koob GF, et al. Influence of alcoholism and cholesterol on TSPO binding in brain: PET [C]PBR28 studies in humans and rodents. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29777199 DOI: 10.1038/s41386-018-0085-x  0.307
2018 Schmeichel BE, Matzeu A, Koebel P, Vendruscolo LF, Sidhu H, Shahryari R, Kieffer BL, Koob GF, Martin-Fardon R, Contet C. Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29703996 DOI: 10.1038/S41386-018-0054-4  0.825
2018 Kenny PJ, Hoyer D, Koob GF. Animal Models of Addiction and Neuropsychiatric Disorders and Their Role in Drug Discovery: Honoring the Legacy of Athina Markou. Biological Psychiatry. PMID 29602521 DOI: 10.1016/J.Biopsych.2018.02.009  0.583
2018 Allen CP, Park K, Li A, Volkow ND, Koob GF, Pan Y, Hu XT, Du C. Enhanced neuronal and blunted hemodynamic reactivity to cocaine in the prefrontal cortex following extended cocaine access: optical imaging study in anesthetized rats. Addiction Biology. PMID 29504647 DOI: 10.1111/Adb.12615  0.392
2018 Logrip ML, Walker JR, Ayanwuyi LO, Sabino V, Ciccocioppo R, Koob GF, Zorrilla EP. Evaluation of Alcohol Preference and Drinking in msP Rats Bearing aPromoter Polymorphism. Frontiers in Psychiatry. 9: 28. PMID 29497387 DOI: 10.3389/Fpsyt.2018.00028  0.809
2018 Zallar LJ, Tunstall BJ, Richie CT, Zhang YJ, You ZB, Gardner EL, Heilig M, Pickel J, Koob GF, Vendruscolo LF, Harvey BK, Leggio L. Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model. International Journal of Obesity (2005). PMID 29453460 DOI: 10.1038/S41366-018-0013-5  0.644
2018 Tian YH, Ma SX, Lee KW, Wee S, Koob GF, Lee SY, Jang CG. Blockade of TRPV1 Inhibits Methamphetamine-induced Rewarding Effects. Scientific Reports. 8: 882. PMID 29343767 DOI: 10.1038/s41598-018-19207-2  0.316
2017 Verheij MMM, Contet C, Karel P, Latour J, van der Doelen RHA, Geenen B, van Hulten JA, Meyer F, Kozicz T, George O, Koob GF, Homberg JR. Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake. Biological Psychiatry. PMID 29357981 DOI: 10.1016/J.Biopsych.2017.10.031  0.807
2017 George O, Koob GF. Individual differences in the neuropsychopathology of addiction. Dialogues in Clinical Neuroscience. 19: 217-229. PMID 29302219  0.683
2017 Tunstall BJ, Ho CP, Cao J, Vendruscolo JCM, Schmeichel BE, Slack RD, Tanda G, Gadiano AJ, Rais R, Slusher BS, Koob GF, Newman AH, Vendruscolo LF. Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats. Neuropharmacology. 131: 96-103. PMID 29217282 DOI: 10.1016/J.Neuropharm.2017.12.006  0.402
2017 Francesconi W, Szücs A, Berton F, Koob GF, Vendruscolo LF, Sanna PP. Opiate dependence induces cell type-specific plasticity of intrinsic membrane properties in the rat juxtacapsular bed nucleus of stria terminalis (jcBNST). Psychopharmacology. PMID 28986608 DOI: 10.1007/s00213-017-4732-4  0.333
2017 Moore CF, Sabino V, Koob GF, Cottone P. Neuroscience of Compulsive Eating Behavior. Frontiers in Neuroscience. 11: 469. PMID 28883784 DOI: 10.3389/Fnins.2017.00469  0.779
2017 Lohoff FW, Sorcher JL, Rosen AD, Mauro KL, Fanelli RR, Momenan R, Hodgkinson CA, Vendruscolo LF, Koob GF, Schwandt M, George DT, Jones IS, Holmes A, Zhou Z, Xu MJ, et al. Methylomic profiling and replication implicates deregulation of PCSK9 in alcohol use disorder. Molecular Psychiatry. PMID 28848234 DOI: 10.1038/Mp.2017.168  0.311
2017 Vendruscolo JC, Tunstall BJ, Carmack SA, Schmeichel BE, Lowery-Gionta EG, Cole M, George O, Vandewater S, Taffe M, Koob GF, Vendruscolo LF. Compulsive-Like Sufentanil Vapor Self-Administration in the Rat. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28812595 DOI: 10.1038/Npp.2017.172  0.803
2017 Tunstall BJ, Carmack SA, Koob GF, Vendruscolo LF. Dysregulation of Brain Stress Systems Mediates Compulsive Alcohol Drinking. Current Opinion in Behavioral Sciences. 13: 85-90. PMID 28603755 DOI: 10.1016/j.cobeha.2016.10.006  0.367
2017 Aoun EG, Jimenez VA, Vendruscolo LF, Walter NAR, Barbier E, Ferrulli A, Haass-Koffler CL, Darakjian P, Lee MR, Addolorato G, Heilig M, Hitzemann R, Koob GF, Grant KA, Leggio L. A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans. Molecular Psychiatry. PMID 28461696 DOI: 10.1038/Mp.2017.97  0.667
2017 Caraci F, Enna SJ, Zohar J, Racagni G, Zalsman G, van den Brink W, Kasper S, Koob GF, Pariante CM, Piazza PV, Yamada K, Spedding M, Drago F. A New Nomenclature for Classifying Psychotropic Drugs. British Journal of Clinical Pharmacology. PMID 28401576 DOI: 10.1111/Bcp.13302  0.54
2017 Cui C, Koob GF. Titrating Tipsy Targets: The Neurobiology of Low-Dose Alcohol. Trends in Pharmacological Sciences. PMID 28372826 DOI: 10.1016/j.tips.2017.03.002  0.329
2017 Galinato MH, Lockner JW, Fannon-Pavlich MJ, Sobieraj JC, Staples MC, Somkuwar SS, Ghofranian A, Chaing S, Navarro AI, Joea A, Luikart BW, Janda KD, Heyser C, Koob GF, Mandyam CD. A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse. Molecular Psychiatry. PMID 28348387 DOI: 10.1038/Mp.2017.46  0.704
2017 Reilly MT, Noronha A, Goldman D, Koob GF. Genetic studies of alcohol dependence in the context of the addiction cycle. Neuropharmacology. PMID 28118990 DOI: 10.1016/J.Neuropharm.2017.01.017  0.306
2017 Koob GF. Antireward, compulsivity, and addiction: seminal contributions of Dr. Athina Markou to motivational dysregulation in addiction. Psychopharmacology. PMID 28050629 DOI: 10.1007/s00213-016-4484-6  0.332
2017 Lowery-Gionta E, Wang H, Vendruscolo L, Sucich D, Tunstall B, Thomas L, Morales M, Koob GF. The role of the Periaqueductal Gray Area in maladaptive emotional and behavioral responses stemming from alcohol dependence Alcohol. 60: 242-243. DOI: 10.1016/J.Alcohol.2017.02.353  0.785
2017 de Guglielmo G, Kallupi M, Crawford E, Koob GF, Messing RO, George O. Optogenetic characterization of CeA CRF pathways in alcohol dependence Alcohol. 60: 235. DOI: 10.1016/J.Alcohol.2017.02.319  0.796
2017 Messing RO, Pomrenze MB, de Guglielmo G, Kallupi M, Koob GF, George O. A distributed CRF network in rat extended amygdala regulates anxiety and excessive alcohol drinking Alcohol. 60: 212. DOI: 10.1016/J.Alcohol.2017.02.221  0.792
2016 Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt J, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, ... ... Koob GF, et al. Genetic and pharmacologic manipulation of TLR4 has minimal impact on ethanol consumption in rodents. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 27986929 DOI: 10.1523/Jneurosci.2002-16.2016  0.811
2016 Moore CF, Sabino V, Koob GF, Cottone P. Pathological Overeating: Emerging Evidence for a Compulsivity Construct. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27922596 DOI: 10.1038/Npp.2016.269  0.785
2016 Wade CL, Kallupi M, Hernandez DO, Breysse E, de Guglielmo G, Crawford E, Koob GF, Schweitzer P, Baunez C, George O. High-Frequency Stimulation of the Subthalamic Nucleus Blocks Compulsive-Like Re-Escalation of Heroin Taking in Rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27917870 DOI: 10.1038/Npp.2016.270  0.813
2016 Ryan ML, Falk DE, Fertig JB, Rendenbach-Mueller B, Katz DA, Tracy KA, Strain EC, Dunn KE, Kampman K, Mahoney E, Ciraulo DA, Sickles-Colaneri L, Ait-Daoud N, Johnson BA, Ransom J, ... ... Koob GF, et al. A Phase 2, Double-Blind, Placebo-Controlled Randomized Trial Assessing the Efficacy of ABT-436, a Novel V1b Receptor Antagonist, for Alcohol Dependence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27658483 DOI: 10.1038/Npp.2016.214  0.353
2016 de Guglielmo G, Crawford E, Kim S, Vendruscolo LF, Hope BT, Brennan M, Cole M, Koob GF, George O. Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala Is Required for Alcohol Dependence. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 9446-53. PMID 27605618 DOI: 10.1523/Jneurosci.1395-16.2016  0.804
2016 Schmeichel BE, Herman MA, Roberto M, Koob GF. Hypocretin Neurotransmission Within the Central Amygdala Mediates Escalated Cocaine Self-Administration and Stress-Induced Reinstatement in Rats. Biological Psychiatry. PMID 27567312 DOI: 10.1016/J.Biopsych.2016.06.010  0.406
2016 Priddy BM, Carmack SA, Thomas LC, Vendruscolo JC, Koob GF, Vendruscolo LF. Sex, strain, and estrous cycle influences on alcohol drinking in rats. Pharmacology, Biochemistry, and Behavior. PMID 27498303 DOI: 10.1016/j.pbb.2016.08.001  0.336
2016 Verheij MM, Vendruscolo LF, Caffino L, Giannotti G, Cazorla M, Fumagalli F, Riva MA, Homberg JR, Koob GF, Contet C. Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 8149-59. PMID 27488635 DOI: 10.1523/Jneurosci.2711-14.2016  0.817
2016 Koob GF, Volkow ND. Neurobiology of addiction: a neurocircuitry analysis. The Lancet. Psychiatry. 3: 760-73. PMID 27475769 DOI: 10.1016/S2215-0366(16)00104-8  0.388
2016 Koob GF. The Dark Side of Addiction: The Horsley Gantt to Joseph Brady Connection. The Journal of Nervous and Mental Disease. PMID 27356121 DOI: 10.1097/NMD.0000000000000551  0.354
2016 Sanna PP, Kawamura T, Chen J, Koob GF, Roberts AJ, Vendruscolo LF, Repunte-Canonigo V. 11β-hydroxysteroid dehydrogenase inhibition as a new potential therapeutic target for alcohol abuse. Translational Psychiatry. 6: e760. PMID 26978742 DOI: 10.1038/tp.2016.13  0.303
2016 Volkow ND, Koob GF, McLellan AT. Neurobiologic Advances from the Brain Disease Model of Addiction. The New England Journal of Medicine. 374: 363-371. PMID 26816013 DOI: 10.1056/NEJMra1511480  0.373
2016 Becker JB, Koob GF. Sex Differences in Animal Models: Focus on Addiction. Pharmacological Reviews. 68: 242-63. PMID 26772794 DOI: 10.1124/pr.115.011163  0.343
2016 Chavkin C, Koob GF. Dynorphin, Dysphoria, and Dependence: the Stress of Addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 41: 373-4. PMID 26657953 DOI: 10.1038/npp.2015.258  0.545
2015 Koob GF, Mason BJ. Existing and Future Drugs for the Treatment of the Dark Side of Addiction. Annual Review of Pharmacology and Toxicology. PMID 26514207 DOI: 10.1146/annurev-pharmtox-010715-103143  0.347
2015 You IJ, Wright SR, Garcia-Garcia AL, Tapper AR, Gardner PD, Koob GF, Leonardo ED, Bohn LM, Wee S. 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26324408 DOI: 10.1038/Npp.2015.268  0.369
2015 Volkow ND, Koob G. Brain disease model of addiction: why is it so controversial? The Lancet. Psychiatry. 2: 677-9. PMID 26249284 DOI: 10.1016/S2215-0366(15)00236-9  0.334
2015 Saba LM, Flink SC, Vanderlinden LA, Israel Y, Tampier L, Colombo G, Kiianmaa K, Bell RL, Printz MP, Flodman P, Koob G, Richardson HN, Lombardo J, Hoffman PL, Tabakoff B. The sequenced rat brain transcriptome - its use in identifying networks predisposing alcohol consumption. The Febs Journal. 282: 3556-78. PMID 26183165 DOI: 10.1111/Febs.13358  0.646
2015 Vendruscolo LF, Estey D, Goodell V, Macshane LG, Logrip ML, Schlosburg JE, McGinn MA, Zamora-Martinez ER, Belanoff JK, Hunt HJ, Sanna PP, George O, Koob GF, Edwards S, Mason BJ. Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals. The Journal of Clinical Investigation. PMID 26121746 DOI: 10.1172/Jci79828  0.805
2015 Cui C, Noronha A, Warren KR, Koob GF, Sinha R, Thakkar M, Matochik J, Crews FT, Chandler LJ, Pfefferbaum A, Becker HC, Lovinger D, Everitt BJ, Egli M, Mandyam CD, et al. Brain pathways to recovery from alcohol dependence. Alcohol (Fayetteville, N.Y.). 49: 435-52. PMID 26074423 DOI: 10.1016/J.Alcohol.2015.04.006  0.696
2015 Repunte-Canonigo V, Shin W, Vendruscolo LF, Lefebvre C, van der Stap L, Kawamura T, Schlosburg JE, Alvarez M, Koob GF, Califano A, Sanna PP. Identifying candidate drivers of alcohol dependence-induced excessive drinking by assembly and interrogation of brain-specific regulatory networks. Genome Biology. 16: 68. PMID 25886852 DOI: 10.1186/S13059-015-0593-5  0.723
2015 Leão RM, Cruz FC, Vendruscolo LF, de Guglielmo G, Logrip ML, Planeta CS, Hope BT, Koob GF, George O. Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6241-53. PMID 25878294 DOI: 10.1523/Jneurosci.3302-14.2015  0.813
2015 Whitfield TW, Schlosburg JE, Wee S, Gould A, George O, Grant Y, Zamora-Martinez ER, Edwards S, Crawford E, Vendruscolo LF, Koob GF. κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 4296-305. PMID 25762676 DOI: 10.1523/Jneurosci.1978-13.2015  0.832
2015 Koob GF. The dark side of emotion: the addiction perspective. European Journal of Pharmacology. 753: 73-87. PMID 25583178 DOI: 10.1016/j.ejphar.2014.11.044  0.324
2015 Schmeichel BE, Barbier E, Misra KK, Contet C, Schlosburg JE, Grigoriadis D, Williams JP, Karlsson C, Pitcairn C, Heilig M, Koob GF, Vendruscolo LF. Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1123-9. PMID 25367502 DOI: 10.1038/Npp.2014.293  0.819
2015 Wade CL, Vendruscolo LF, Schlosburg JE, Hernandez DO, Koob GF. Compulsive-like responding for opioid analgesics in rats with extended access. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 421-8. PMID 25060491 DOI: 10.1038/Npp.2014.188  0.707
2015 Cohen A, Soleiman MT, Talia R, Koob GF, George O, Mandyam CD. Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus. Psychopharmacology. 232: 453-63. PMID 25059540 DOI: 10.1007/S00213-014-3685-0  0.79
2015 Park PE, Schlosburg JE, Vendruscolo LF, Schulteis G, Edwards S, Koob GF. Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia. Addiction Biology. 20: 275-84. PMID 24330252 DOI: 10.1111/Adb.12120  0.765
2015 Cohen A, Treweek J, Edwards S, Leão RM, Schulteis G, Koob GF, George O. Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats. Addiction Biology. 20: 56-68. PMID 23869743 DOI: 10.1111/Adb.12077  0.808
2015 Saba LM, Flink SC, Vanderlinden LA, Israel Y, Tampier L, Colombo G, Kiianmaa K, Bell RL, Printz MP, Flodman P, Koob G, Richardson HN, Lombardo J, Hoffman PL, Tabakoff B. The sequenced rat brain transcriptome - its use in identifying networks predisposing alcohol consumption Febs Journal. DOI: 10.1111/febs.13358  0.61
2014 Grieder TE, Herman MA, Contet C, Tan LA, Vargas-Perez H, Cohen A, Chwalek M, Maal-Bared G, Freiling J, Schlosburg JE, Clarke L, Crawford E, Koebel P, Repunte-Canonigo V, Sanna PP, ... ... Koob GF, et al. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nature Neuroscience. 17: 1751-8. PMID 25402857 DOI: 10.1038/Nn.3872  0.797
2014 Koob GF. Neurocircuitry of alcohol addiction: synthesis from animal models. Handbook of Clinical Neurology. 125: 33-54. PMID 25307567 DOI: 10.1016/B978-0-444-62619-6.00003-3  0.438
2014 Koob GF. Pl1Addiction As A Reward, Stress And Executive Function Disorder Alcohol and Alcoholism. 49. PMID 25220982 DOI: 10.1093/Alcalc/Agu051.1  0.363
2014 Repunte-Canonigo V, Lefebvre C, George O, Kawamura T, Morales M, Koob GF, Califano A, Masliah E, Sanna PP. Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats. Molecular Neurodegeneration. 9: 26. PMID 24980976 DOI: 10.1186/1750-1326-9-26  0.717
2014 Vanderlinden LA, Saba LM, Printz MP, Flodman P, Koob G, Richardson HN, Hoffman PL, Tabakoff B. Is the alcohol deprivation effect genetically mediated? Studies with HXB/BXH recombinant inbred rat strains. Alcoholism, Clinical and Experimental Research. 38: 2148-57. PMID 24961585 DOI: 10.1111/Acer.12471  0.649
2014 George O, Koob GF, Vendruscolo LF. Negative reinforcement via motivational withdrawal is the driving force behind the transition to addiction. Psychopharmacology. 231: 3911-7. PMID 24923982 DOI: 10.1007/S00213-014-3623-1  0.678
2014 Buck CL, Malavar JC, George O, Koob GF, Vendruscolo LF. Anticipatory 50 kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats. Behavioural Brain Research. 271: 171-6. PMID 24914463 DOI: 10.1016/J.Bbr.2014.06.003  0.735
2014 Cohen A, Whitfield TW, Kreifeldt M, Koebel P, Kieffer BL, Contet C, George O, Koob GF. Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. Plos One. 9: e97216. PMID 24816773 DOI: 10.1371/Journal.Pone.0097216  0.819
2014 Mazei-Robison MS, Appasani R, Edwards S, Wee S, Taylor SR, Picciotto MR, Koob GF, Nestler EJ. Self-administration of ethanol, cocaine, or nicotine does not decrease the soma size of ventral tegmental area dopamine neurons. Plos One. 9: e95962. PMID 24755634 DOI: 10.1371/Journal.Pone.0095962  0.593
2014 Hicks MJ, Kaminsky SM, De BP, Rosenberg JB, Evans SM, Foltin RW, Andrenyak DM, Moody DE, Koob GF, Janda KD, Ricart Arbona RJ, Lepherd ML, Crystal RG. Fate of systemically administered cocaine in nonhuman primates treated with the dAd5GNE anticocaine vaccine. Human Gene Therapy. Clinical Development. 25: 40-9. PMID 24649839 DOI: 10.1089/Humc.2013.231  0.499
2014 Logrip ML, Vendruscolo LF, Schlosburg JE, Koob GF, Zorrilla EP. Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1722-31. PMID 24549104 DOI: 10.1038/Npp.2014.20  0.823
2014 Hicks MJ, Kaminsky SM, De BP, Rosenberg JB, Evans SM, Foltin RW, Andrenyak DM, Moody DE, Koob GF, Janda KD, Ricart Arbona RJ, Lepherd M, Crystal RG. Fate of Systemically Administered Cocaine in Nonhuman Primates Treated with the dAd5GNE Anti-cocaine Vaccine. Human Gene Therapy. Clinical Development. PMID 24548017 DOI: 10.1089/hum.2013.231  0.426
2014 Zorrilla EP, Logrip ML, Koob GF. Corticotropin releasing factor: a key role in the neurobiology of addiction. Frontiers in Neuroendocrinology. 35: 234-44. PMID 24456850 DOI: 10.1016/j.yfrne.2014.01.001  0.818
2014 Buck CL, Vendruscolo LF, Koob GF, George O. Dopamine D1 and μ-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats. Psychopharmacology. 231: 929-37. PMID 24221826 DOI: 10.1007/S00213-013-3307-2  0.733
2014 Gilpin NW, Roberto M, Koob GF, Schweitzer P. Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala. Neuropharmacology. 77: 294-302. PMID 24157490 DOI: 10.1016/J.Neuropharm.2013.10.005  0.669
2014 Wise RA, Koob GF. The development and maintenance of drug addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 254-62. PMID 24121188 DOI: 10.1038/npp.2013.261  0.326
2014 Koob GF, Buck CL, Cohen A, Edwards S, Park PE, Schlosburg JE, Schmeichel B, Vendruscolo LF, Wade CL, Whitfield TW, George O. Addiction as a stress surfeit disorder. Neuropharmacology. 76: 370-82. PMID 23747571 DOI: 10.1016/J.Neuropharm.2013.05.024  0.818
2014 Kallupi M, Vendruscolo LF, Carmichael CY, George O, Koob GF, Gilpin NW. Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats. Addiction Biology. 19: 755-7. PMID 23639035 DOI: 10.1111/Adb.12059  0.811
2014 Deschaux O, Vendruscolo LF, Schlosburg JE, Diaz-Aguilar L, Yuan CJ, Sobieraj JC, George O, Koob GF, Mandyam CD. Hippocampal neurogenesis protects against cocaine-primed relapse. Addiction Biology. 19: 562-74. PMID 23278919 DOI: 10.1111/Adb.12019  0.816
2014 Koob GF. SY07-3 * MEDICATIONS FOR TREATMENT OF ALCOHOLISM THAT DERIVE FROM THE DARK SIDE OF ADDICTION Alcohol and Alcoholism. 49: i9-i9. DOI: 10.1093/alcalc/agu052.35  0.4
2013 Kreifeldt M, Le D, Treistman SN, Koob GF, Contet C. BK channel β1 and β4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice. Frontiers in Integrative Neuroscience. 7: 105. PMID 24416005 DOI: 10.3389/Fnint.2013.00105  0.785
2013 Schlosburg JE, Whitfield TW, Park PE, Crawford EF, George O, Vendruscolo LF, Koob GF. Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 19384-92. PMID 24305833 DOI: 10.1523/Jneurosci.1979-13.2013  0.829
2013 Apkarian AV, Neugebauer V, Koob G, Edwards S, Levine JD, Ferrari L, Egli M, Regunathan S. Neural mechanisms of pain and alcohol dependence. Pharmacology, Biochemistry, and Behavior. 112: 34-41. PMID 24095683 DOI: 10.1016/J.Pbb.2013.09.008  0.522
2013 Zorrilla EP, Roberts AJ, Rivier JE, Koob GF. Anxiolytic-like effects of antisauvagine-30 in mice are not mediated by CRF2 receptors. Plos One. 8: e63942. PMID 24015170 DOI: 10.1371/journal.pone.0063942  0.738
2013 Edwards S, Baynes BB, Carmichael CY, Zamora-Martinez ER, Barrus M, Koob GF, Gilpin NW. Traumatic stress reactivity promotes excessive alcohol drinking and alters the balance of prefrontal cortex-amygdala activity. Translational Psychiatry. 3: e296. PMID 23982628 DOI: 10.1038/Tp.2013.70  0.721
2013 Cai X, Whitfield T, Moreno AY, Grant Y, Hixon MS, Koob GF, Janda KD. Probing the effects of hapten stability on cocaine vaccine immunogenicity. Molecular Pharmaceutics. 10: 4176-84. PMID 23927436 DOI: 10.1021/Mp400214W  0.491
2013 Koob GF. Addiction is a Reward Deficit and Stress Surfeit Disorder. Frontiers in Psychiatry. 4: 72. PMID 23914176 DOI: 10.3389/fpsyt.2013.00072  0.414
2013 Edwards S, Koob GF. Escalation of drug self-administration as a hallmark of persistent addiction liability. Behavioural Pharmacology. 24: 356-62. PMID 23839030 DOI: 10.1097/Fbp.0B013E3283644D15  0.538
2013 Kallupi M, Wee S, Edwards S, Whitfield TW, Oleata CS, Luu G, Schmeichel BE, Koob GF, Roberto M. Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction. Biological Psychiatry. 74: 520-8. PMID 23751206 DOI: 10.1016/J.Biopsych.2013.04.028  0.748
2013 Chen J, Repunte-Canonigo V, Kawamura T, Lefebvre C, Shin W, Howell LL, Hemby SE, Harvey BK, Califano A, Morales M, Koob GF, Sanna PP. Hypothalamic proteoglycan syndecan-3 is a novel cocaine addiction resilience factor. Nature Communications. 4: 1955. PMID 23736082 DOI: 10.1038/Ncomms2955  0.562
2013 Maoz A, Hicks MJ, Vallabhjosula S, Synan M, Kothari PJ, Dyke JP, Ballon DJ, Kaminsky SM, De BP, Rosenberg JB, Martinez D, Koob GF, Janda KD, Crystal RG. Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2170-8. PMID 23660705 DOI: 10.1038/Npp.2013.114  0.49
2013 Schlosburg JE, Vendruscolo LF, Bremer PT, Lockner JW, Wade CL, Nunes AA, Stowe GN, Edwards S, Janda KD, Koob GF. Dynamic vaccine blocks relapse to compulsive intake of heroin. Proceedings of the National Academy of Sciences of the United States of America. 110: 9036-41. PMID 23650354 DOI: 10.1073/Pnas.1219159110  0.776
2013 Koob GF. Negative reinforcement in drug addiction: the darkness within. Current Opinion in Neurobiology. 23: 559-63. PMID 23628232 DOI: 10.1016/j.conb.2013.03.011  0.369
2013 Cai X, Whitfield T, Hixon MS, Grant Y, Koob GF, Janda KD. Probing active cocaine vaccination performance through catalytic and noncatalytic hapten design. Journal of Medicinal Chemistry. 56: 3701-9. PMID 23627877 DOI: 10.1021/Jm400228W  0.492
2013 Park PE, Vendruscolo LF, Schlosburg JE, Edwards S, Schulteis G, Koob GF. Corticotropin-releasing factor (CRF) and α 2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 16: 1867-75. PMID 23590881 DOI: 10.1017/S1461145713000308  0.78
2013 George O, Koob GF. Control of craving by the prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America. 110: 4165-6. PMID 23483010 DOI: 10.1073/Pnas.1301245110  0.696
2013 Robison AJ, Vialou V, Mazei-Robison M, Feng J, Kourrich S, Collins M, Wee S, Koob G, Turecki G, Neve R, Thomas M, Nestler EJ. Behavioral and structural responses to chronic cocaine require a feedforward loop involving ΔFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 4295-307. PMID 23467346 DOI: 10.1523/Jneurosci.5192-12.2013  0.391
2013 Barbier E, Vendruscolo LF, Schlosburg JE, Edwards S, Juergens N, Park PE, Misra KK, Cheng K, Rice KC, Schank J, Schulteis G, Koob GF, Heilig M. The NK1 receptor antagonist L822429 reduces heroin reinforcement. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 976-84. PMID 23303056 DOI: 10.1038/Npp.2012.261  0.83
2013 Zorrilla EP, Koob GF. Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley. Neuroscience and Biobehavioral Reviews. 37: 1932-45. PMID 23220696 DOI: 10.1016/j.neubiorev.2012.11.019  0.71
2013 Herman MA, Kallupi M, Luu G, Oleata CS, Heilig M, Koob GF, Ciccocioppo R, Roberto M. Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: alcohol and CRF effects. Neuropharmacology. 67: 337-48. PMID 23220399 DOI: 10.1016/J.Neuropharm.2012.11.026  0.822
2013 De BP, Pagovich OE, Hicks MJ, Rosenberg JB, Moreno AY, Janda KD, Koob GF, Worgall S, Kaminsky SM, Sondhi D, Crystal RG. Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity. Human Gene Therapy. 24: 58-66. PMID 23140508 DOI: 10.1089/Hum.2012.163  0.423
2013 Jang CG, Whitfield T, Schulteis G, Koob GF, Wee S. A dysphoric-like state during early withdrawal from extended access to methamphetamine self-administration in rats. Psychopharmacology. 225: 753-63. PMID 23007601 DOI: 10.1007/S00213-012-2864-0  0.389
2013 Koob GF. Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder. Current Topics in Behavioral Neurosciences. 13: 3-30. PMID 21744309 DOI: 10.1007/7854_2011_129  0.431
2012 George O, Sanders C, Freiling J, Grigoryan E, Vu S, Allen CD, Crawford E, Mandyam CD, Koob GF. Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proceedings of the National Academy of Sciences of the United States of America. 109: 18156-61. PMID 23071333 DOI: 10.1073/Pnas.1116523109  0.801
2012 Egli M, Koob GF, Edwards S. Alcohol dependence as a chronic pain disorder. Neuroscience and Biobehavioral Reviews. 36: 2179-92. PMID 22975446 DOI: 10.1016/J.Neubiorev.2012.07.010  0.511
2012 Moreno AY, Azar MR, Koob GF, Janda KD. Probing the protective effects of a conformationally constrained nicotine vaccine. Vaccine. 30: 6665-70. PMID 22963803 DOI: 10.1016/J.Vaccine.2012.08.064  0.446
2012 Wee S, Vendruscolo LF, Misra KK, Schlosburg JE, Koob GF. A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence. Science Translational Medicine. 4: 146ra110. PMID 22875830 DOI: 10.1126/Scitranslmed.3003948  0.721
2012 Vendruscolo LF, Barbier E, Schlosburg JE, Misra KK, Whitfield TW, Logrip ML, Rivier C, Repunte-Canonigo V, Zorrilla EP, Sanna PP, Heilig M, Koob GF. Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 7563-71. PMID 22649234 DOI: 10.1523/Jneurosci.0069-12.2012  0.808
2012 Koob GF. Animal models of psychiatric disorders. Handbook of Clinical Neurology. 106: 137-66. PMID 22608620 DOI: 10.1016/B978-0-444-52002-9.00009-7  0.376
2012 Cohen A, Koob GF, George O. Robust escalation of nicotine intake with extended access to nicotine self-administration and intermittent periods of abstinence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 2153-60. PMID 22549121 DOI: 10.1038/Npp.2012.67  0.745
2012 Tobey KM, Walentiny DM, Wiley JL, Carroll FI, Damaj MI, Azar MR, Koob GF, George O, Harris LS, Vann RE. Effects of the specific α4β2 nAChR antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and mice. Psychopharmacology. 223: 159-68. PMID 22526534 DOI: 10.1007/S00213-012-2703-3  0.706
2012 Rosenberg JB, Hicks MJ, De BP, Pagovich O, Frenk E, Janda KD, Wee S, Koob GF, Hackett NR, Kaminsky SM, Worgall S, Tignor N, Mezey JG, Crystal RG. AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior. Human Gene Therapy. 23: 451-9. PMID 22486244 DOI: 10.1089/Hum.2011.178  0.496
2012 Goeders NE, Cohen A, Fox BS, Azar MR, George O, Koob GF. Effects of the combination of metyrapone and oxazepam on intravenous nicotine self-administration in rats. Psychopharmacology. 223: 17-25. PMID 22418732 DOI: 10.1007/S00213-012-2682-4  0.756
2012 Mandyam CD, Koob GF. The addicted brain craves new neurons: putative role for adult-born progenitors in promoting recovery. Trends in Neurosciences. 35: 250-60. PMID 22265158 DOI: 10.1016/j.tins.2011.12.005  0.648
2012 Edwards S, Koob GF. Experimental psychiatric illness and drug abuse models: from human to animal, an overview. Methods in Molecular Biology (Clifton, N.J.). 829: 31-48. PMID 22231805 DOI: 10.1007/978-1-61779-458-2_2  0.481
2012 Recinto P, Samant AR, Chavez G, Kim A, Yuan CJ, Soleiman M, Grant Y, Edwards S, Wee S, Koob GF, George O, Mandyam CD. Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1275-87. PMID 22205547 DOI: 10.1038/Npp.2011.315  0.816
2012 Koob GF, Zorrilla EP. Update on corticotropin-releasing factor pharmacotherapy for psychiatric disorders: a revisionist view. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 308-9. PMID 22157874 DOI: 10.1038/npp.2011.213  0.726
2012 Edwards S, Vendruscolo LF, Schlosburg JE, Misra KK, Wee S, Park PE, Schulteis G, Koob GF. Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by CRF₁ receptor antagonism. Neuropharmacology. 62: 1142-51. PMID 22119954 DOI: 10.1016/J.Neuropharm.2011.11.006  0.79
2012 George O, Le Moal M, Koob GF. Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems. Physiology & Behavior. 106: 58-64. PMID 22108506 DOI: 10.1016/J.Physbeh.2011.11.004  0.757
2012 Lenoir M, Guillem K, Koob GF, Ahmed SH. Drug specificity in extended access cocaine and heroin self-administration. Addiction Biology. 17: 964-76. PMID 21995515 DOI: 10.1111/j.1369-1600.2011.00385.x  0.682
2012 Wee S, Hicks MJ, De BP, Rosenberg JB, Moreno AY, Kaminsky SM, Janda KD, Crystal RG, Koob GF. Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1083-91. PMID 21918504 DOI: 10.1038/Npp.2011.200  0.517
2012 Logrip ML, Zorrilla EP, Koob GF. Stress modulation of drug self-administration: implications for addiction comorbidity with post-traumatic stress disorder. Neuropharmacology. 62: 552-64. PMID 21782834 DOI: 10.1016/j.neuropharm.2011.07.007  0.792
2012 Zorrilla EP, Wee S, Zhao Y, Specio S, Boutrel B, Koob GF, Weiss F. Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats. Addiction Biology. 17: 300-8. PMID 21762287 DOI: 10.1111/J.1369-1600.2011.00329.X  0.821
2012 Edwards S, Guerrero M, Ghoneim OM, Roberts E, Koob GF. Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. Addiction Biology. 17: 76-85. PMID 21309953 DOI: 10.1111/J.1369-1600.2010.00291.X  0.59
2012 Blednov YA, Ponomarev I, Geil C, Bergeson S, Koob GF, Harris RA. Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies. Addiction Biology. 17: 108-20. PMID 21309947 DOI: 10.1111/J.1369-1600.2010.00284.X  0.345
2011 Koob G, Hicks MJ, Wee S, Rosenberg JB, De BP, Kaminsky SM, Moreno A, Janda KD, Crystal RG. Anti-cocaine vaccine based on coupling a cocaine analog to a disrupted adenovirus. Cns & Neurological Disorders Drug Targets. 10: 899-904. PMID 22229312 DOI: 10.2174/187152711799219334  0.5
2011 Stowe GN, Schlosburg JE, Vendruscolo LF, Edwards S, Misra KK, Schulteis G, Zakhari JS, Koob GF, Janda KD. Developing a vaccine against multiple psychoactive targets: a case study of heroin. Cns & Neurological Disorders Drug Targets. 10: 865-75. PMID 22229311 DOI: 10.2174/187152711799219316  0.761
2011 Stowe GN, Vendruscolo LF, Edwards S, Schlosburg JE, Misra KK, Schulteis G, Mayorov AV, Zakhari JS, Koob GF, Janda KD. A vaccine strategy that induces protective immunity against heroin. Journal of Medicinal Chemistry. 54: 5195-204. PMID 21692508 DOI: 10.1021/Jm200461M  0.756
2011 Fekete EM, Zhao Y, Szücs A, Sabino V, Cottone P, Rivier J, Vale WW, Koob GF, Zorrilla EP. Systemic urocortin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress. British Journal of Pharmacology. 164: 1959-75. PMID 21627635 DOI: 10.1111/J.1476-5381.2011.01512.X  0.801
2011 Mihindou C, Vouillac C, Koob GF, Ahmed SH. Preclinical validation of a novel cocaine exposure therapy for relapse prevention. Biological Psychiatry. 70: 593-8. PMID 21571256 DOI: 10.1016/j.biopsych.2011.03.036  0.641
2011 Parylak SL, Koob GF, Zorrilla EP. The dark side of food addiction. Physiology & Behavior. 104: 149-56. PMID 21557958 DOI: 10.1016/J.Physbeh.2011.04.063  0.731
2011 Gilpin NW, Misra K, Herman MA, Cruz MT, Koob GF, Roberto M. Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence. Biological Psychiatry. 69: 1091-9. PMID 21459365 DOI: 10.1016/J.Biopsych.2011.02.004  0.639
2011 George O, Koob GF. Craving, context and the cortex. Nature Neuroscience. 14: 409-10. PMID 21445066 DOI: 10.1038/Nn.2787  0.685
2011 Logrip ML, Koob GF, Zorrilla EP. Role of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention. Cns Drugs. 25: 271-87. PMID 21425881 DOI: 10.2165/11587790-000000000-00000  0.813
2011 Vendruscolo LF, Schlosburg JE, Misra KK, Chen SA, Greenwell TN, Koob GF. Escalation patterns of varying periods of heroin access. Pharmacology, Biochemistry, and Behavior. 98: 570-4. PMID 21406200 DOI: 10.1016/J.Pbb.2011.03.004  0.796
2011 Contet C, Gardon O, Filliol D, Becker JA, Koob GF, Kieffer BL. Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence. Addiction Biology. 16: 615-9. PMID 21392173 DOI: 10.1111/J.1369-1600.2010.00304.X  0.799
2011 Sabino V, Cottone P, Blasio A, Iyer MR, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1207-18. PMID 21346735 DOI: 10.1038/Npp.2011.5  0.831
2011 Allen CD, Lee S, Koob GF, Rivier C. Immediate and prolonged effects of alcohol exposure on the activity of the hypothalamic-pituitary-adrenal axis in adult and adolescent rats. Brain, Behavior, and Immunity. 25: S50-60. PMID 21300146 DOI: 10.1016/j.bbi.2011.01.016  0.387
2011 Crabbe JC, Harris RA, Koob GF. Preclinical studies of alcohol binge drinking. Annals of the New York Academy of Sciences. 1216: 24-40. PMID 21272009 DOI: 10.1111/J.1749-6632.2010.05895.X  0.355
2011 Hicks MJ, De BP, Rosenberg JB, Davidson JT, Moreno AY, Janda KD, Wee S, Koob GF, Hackett NR, Kaminsky SM, Worgall S, Toth M, Mezey JG, Crystal RG. Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 612-9. PMID 21206484 DOI: 10.1038/Mt.2010.280  0.49
2011 George O, Lloyd A, Carroll FI, Damaj MI, Koob GF. Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration. Psychopharmacology. 213: 715-22. PMID 20924754 DOI: 10.1007/S00213-010-2024-3  0.696
2011 Walker BM, Zorrilla EP, Koob GF. Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats. Addiction Biology. 16: 116-9. PMID 20579007 DOI: 10.1111/j.1369-1600.2010.00226.x  0.822
2011 Ahmed SH, Koob GF. Erratum to: Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function Psychopharmacology. 220: 247-247. DOI: 10.1007/s00213-011-2591-y  0.593
2010 Gilpin NW, Koob GF. Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats. Psychopharmacology. 212: 431-9. PMID 20676608 DOI: 10.1007/S00213-010-1967-8  0.653
2010 Edwards S, Koob GF. Neurobiology of dysregulated motivational systems in drug addiction. Future Neurology. 5: 393-401. PMID 20563312 DOI: 10.2217/Fnl.10.14  0.536
2010 George O, Koob GF. Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neuroscience and Biobehavioral Reviews. 35: 232-47. PMID 20493211 DOI: 10.1016/J.Neubiorev.2010.05.002  0.704
2010 Orio L, Wee S, Newman AH, Pulvirenti L, Koob GF. The dopamine D3 receptor partial agonist CJB090 and antagonist PG01037 decrease progressive ratio responding for methamphetamine in rats with extended-access. Addiction Biology. 15: 312-23. PMID 20456290 DOI: 10.1111/J.1369-1600.2010.00211.X  0.675
2010 George O, Grieder TE, Cole M, Koob GF. Exposure to chronic intermittent nicotine vapor induces nicotine dependence. Pharmacology, Biochemistry, and Behavior. 96: 104-7. PMID 20420848 DOI: 10.1016/J.Pbb.2010.04.013  0.781
2010 Wee S, Koob GF. The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse. Psychopharmacology. 210: 121-35. PMID 20352414 DOI: 10.1007/s00213-010-1825-8  0.369
2010 Zorrilla EP, Koob GF. Progress in corticotropin-releasing factor-1 antagonist development. Drug Discovery Today. 15: 371-83. PMID 20206287 DOI: 10.1016/j.drudis.2010.02.011  0.723
2010 Moreno AY, Azar MR, Warren NA, Dickerson TJ, Koob GF, Janda KD. A critical evaluation of a nicotine vaccine within a self-administration behavioral model. Molecular Pharmaceutics. 7: 431-41. PMID 20104903 DOI: 10.1021/Mp900213U  0.466
2010 Roberto M, Cruz MT, Gilpin NW, Sabino V, Schweitzer P, Bajo M, Cottone P, Madamba SG, Stouffer DG, Zorrilla EP, Koob GF, Siggins GR, Parsons LH. Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence. Biological Psychiatry. 67: 831-9. PMID 20060104 DOI: 10.1016/J.Biopsych.2009.11.007  0.795
2010 Koob GF, Zorrilla EP. Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor. Current Opinion in Investigational Drugs (London, England : 2000). 11: 63-71. PMID 20047160  0.715
2010 Koob GF. The role of CRF and CRF-related peptides in the dark side of addiction. Brain Research. 1314: 3-14. PMID 19912996 DOI: 10.1016/j.brainres.2009.11.008  0.407
2010 Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 217-38. PMID 19710631 DOI: 10.1038/npp.2009.110  0.338
2009 Koob GF, Simon EJ. The Neurobiology of Addiction: Where We Have Been and Where We Are Going. Journal of Drug Issues. 39: 115-132. PMID 20622969 DOI: 10.1177/002204260903900110  0.356
2009 Roberto M, Koob GF. First Congress of "Alcoholism and stress: a framework for future treatment strategies": Introduction to the proceeding. Alcohol (Fayetteville, N.Y.). 43: 489-90. PMID 19913191 DOI: 10.1016/J.Alcohol.2009.10.008  0.312
2009 Cottone P, Sabino V, Roberto M, Bajo M, Pockros L, Frihauf JB, Fekete EM, Steardo L, Rice KC, Grigoriadis DE, Conti B, Koob GF, Zorrilla EP. CRF system recruitment mediates dark side of compulsive eating. Proceedings of the National Academy of Sciences of the United States of America. 106: 20016-20. PMID 19901333 DOI: 10.1073/Pnas.0908789106  0.801
2009 Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, et al. Genetical genomic determinants of alcohol consumption in rats and humans. Bmc Biology. 7: 70. PMID 19874574 DOI: 10.1186/1741-7007-7-70  0.658
2009 Gilpin NW, Smith AD, Cole M, Weiss F, Koob GF, Richardson HN. Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats. Alcoholism, Clinical and Experimental Research. 33: 2113-23. PMID 19740131 DOI: 10.1111/J.1530-0277.2009.01051.X  0.796
2009 Francesconi W, Berton F, Koob GF, Sanna PP. Intrinsic neuronal plasticity in the juxtacapsular nucleus of the bed nuclei of the stria terminalis (jcBNST). Progress in Neuro-Psychopharmacology & Biological Psychiatry. 33: 1347-55. PMID 19683025 DOI: 10.1016/j.pnpbp.2009.08.003  0.416
2009 Richardson HN, Chan SH, Crawford EF, Lee YK, Funk CK, Koob GF, Mandyam CD. Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence. Neurobiology of Disease. 36: 1-10. PMID 19501165 DOI: 10.1016/j.nbd.2009.05.021  0.797
2009 Wee S, Orio L, Ghirmai S, Cashman JR, Koob GF. Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine. Psychopharmacology. 205: 565-75. PMID 19484223 DOI: 10.1007/S00213-009-1563-Y  0.685
2009 Koob GF, Kenneth Lloyd G, Mason BJ. Development of pharmacotherapies for drug addiction: a Rosetta stone approach. Nature Reviews. Drug Discovery. 8: 500-15. PMID 19483710 DOI: 10.1038/nrd2828  0.313
2009 Sabino V, Cottone P, Zhao Y, Steardo L, Koob GF, Zorrilla EP. Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist. Psychopharmacology. 205: 327-35. PMID 19440699 DOI: 10.1007/S00213-009-1548-X  0.814
2009 Koob GF. Dynamics of neuronal circuits in addiction: reward, antireward, and emotional memory. Pharmacopsychiatry. 42: S32-41. PMID 19434554 DOI: 10.1055/s-0029-1216356  0.372
2009 Francesconi W, Berton F, Repunte-Canonigo V, Hagihara K, Thurbon D, Lekic D, Specio SE, Greenwell TN, Chen SA, Rice KC, Richardson HN, O'Dell LE, Zorrilla EP, Morales M, Koob GF, et al. Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5389-401. PMID 19403807 DOI: 10.1523/Jneurosci.5129-08.2009  0.83
2009 Orio L, Edwards S, George O, Parsons LH, Koob GF. A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 4846-57. PMID 19369553 DOI: 10.1523/Jneurosci.0563-09.2009  0.824
2009 Koob GF. Brain stress systems in the amygdala and addiction. Brain Research. 1293: 61-75. PMID 19332030 DOI: 10.1016/j.brainres.2009.03.038  0.352
2009 Greenwell TN, Funk CK, Cottone P, Richardson HN, Chen SA, Rice KC, Zorrilla EP, Koob GF. Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats. Addiction Biology. 14: 130-43. PMID 19291009 DOI: 10.1111/j.1369-1600.2008.00142.x  0.819
2009 Sabino V, Cottone P, Zhao Y, Iyer MR, Steardo L, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 1482-93. PMID 18946467 DOI: 10.1038/Npp.2008.192  0.818
2009 Koob GF. Neurobiological substrates for the dark side of compulsivity in addiction. Neuropharmacology. 56: 18-31. PMID 18725236 DOI: 10.1016/j.neuropharm.2008.07.043  0.407
2009 Greenwell TN, Walker BM, Cottone P, Zorrilla EP, Koob GF. The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration. Pharmacology, Biochemistry, and Behavior. 91: 295-302. PMID 18703080 DOI: 10.1016/j.pbb.2008.07.012  0.809
2009 Ahmed SH, Koob GF. Rapid extinction of cocaine craving: toward a novel cue exposure therapy Nature Precedings. DOI: 10.1038/Npre.2009.2980.1  0.305
2008 Koob GF. Hedonic Homeostatic Dysregulation as a Driver of Drug-Seeking Behavior. Drug Discovery Today. Disease Models. 5: 207-215. PMID 20054425 DOI: 10.1016/j.ddmod.2009.04.002  0.413
2008 Gilpin NW, Koob GF. Neurobiology of alcohol dependence: focus on motivational mechanisms. Alcohol Research & Health : the Journal of the National Institute On Alcohol Abuse and Alcoholism. 31: 185-95. PMID 19881886  0.621
2008 Richardson HN, Lee SY, O'Dell LE, Koob GF, Rivier CL. Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state. The European Journal of Neuroscience. 28: 1641-53. PMID 18979677 DOI: 10.1111/j.1460-9568.2008.06455.x  0.792
2008 Du X, Schwander M, Moresco EM, Viviani P, Haller C, Hildebrand MS, Pak K, Tarantino L, Roberts A, Richardson H, Koob G, Najmabadi H, Ryan AF, Smith RJ, Müller U, et al. A catechol-O-methyltransferase that is essential for auditory function in mice and humans. Proceedings of the National Academy of Sciences of the United States of America. 105: 14609-14. PMID 18794526 DOI: 10.1073/Pnas.0807219105  0.581
2008 Koob GF, Le Moal M. Review. Neurobiological mechanisms for opponent motivational processes in addiction. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 363: 3113-23. PMID 18653439 DOI: 10.1098/rstb.2008.0094  0.611
2008 Gilpin NW, Richardson HN, Cole M, Koob GF. Vapor inhalation of alcohol in rats. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 9.29. PMID 18634001 DOI: 10.1002/0471142301.Ns0929S44  0.757
2008 Gilpin NW, Richardson HN, Koob GF. Effects of CRF1-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (P) rats. Alcoholism, Clinical and Experimental Research. 32: 1535-42. PMID 18631323 DOI: 10.1111/J.1530-0277.2008.00745.X  0.777
2008 Koob GF. A role for brain stress systems in addiction. Neuron. 59: 11-34. PMID 18614026 DOI: 10.1016/j.neuron.2008.06.012  0.333
2008 Walker BM, Koob GF. Regarding "Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake". Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 2113; author reply 2. PMID 18593720 DOI: 10.1096/fj.08-0702LTR  0.672
2008 Koob GF. Corticotropin-releasing factor, neuroplasticity (sensitization), and alcoholism. Proceedings of the National Academy of Sciences of the United States of America. 105: 8809-10. PMID 18583480 DOI: 10.1073/pnas.0804354105  0.409
2008 Roberto M, Gilpin NW, O'Dell LE, Cruz MT, Morse AC, Siggins GR, Koob GF. Cellular and behavioral interactions of gabapentin with alcohol dependence. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 5762-71. PMID 18509038 DOI: 10.1523/Jneurosci.0575-08.2008  0.807
2008 Gilpin NW, Misra K, Koob GF. Neuropeptide Y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinking. Pharmacology, Biochemistry, and Behavior. 90: 475-80. PMID 18501411 DOI: 10.1016/J.Pbb.2008.04.006  0.667
2008 Mandyam CD, Wee S, Crawford EF, Eisch AJ, Richardson HN, Koob GF. Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis. Biological Psychiatry. 64: 958-65. PMID 18490002 DOI: 10.1016/j.biopsych.2008.04.010  0.754
2008 Gilpin NW, Richardson HN, Lumeng L, Koob GF. Dependence-induced alcohol drinking by alcohol-preferring (P) rats and outbred Wistar rats. Alcoholism, Clinical and Experimental Research. 32: 1688-96. PMID 18482158 DOI: 10.1111/J.1530-0277.2008.00678.X  0.761
2008 Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, ... ... Koob GF, et al. It is time to take a stand for medical research and against terrorism targeting medical scientists. Biological Psychiatry. 63: 725-7. PMID 18371494 DOI: 10.1016/J.Biopsych.2008.03.005  0.589
2008 Walker BM, Rasmussen DD, Raskind MA, Koob GF. alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol. Alcohol (Fayetteville, N.Y.). 42: 91-7. PMID 18358987 DOI: 10.1016/j.alcohol.2007.12.002  0.69
2008 Papaleo F, Ghozland S, Ingallinesi M, Roberts AJ, Koob GF, Contarino A. Disruption of the CRF(2) receptor pathway decreases the somatic expression of opiate withdrawal. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2878-87. PMID 18288089 DOI: 10.1038/Npp.2008.8  0.725
2008 Ji D, Gilpin NW, Richardson HN, Rivier CL, Koob GF. Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats. Behavioural Pharmacology. 19: 1-12. PMID 18195589 DOI: 10.1097/Fbp.0B013E3282F3Cf70  0.768
2008 Koob GF. Alcoholism, corticotropin-releasing factor, and molecular genetic allostasis. Biological Psychiatry. 63: 137-8. PMID 18164903 DOI: 10.1016/j.biopsych.2007.10.005  0.46
2008 Koob GF, Le Moal M. Addiction and the brain antireward system. Annual Review of Psychology. 59: 29-53. PMID 18154498 DOI: 10.1146/annurev.psych.59.103006.093548  0.567
2008 George O, Mandyam CD, Wee S, Koob GF. Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2474-82. PMID 18033234 DOI: 10.1038/Sj.Npp.1301626  0.793
2008 Richardson HN, Zhao Y, Fekete EM, Funk CK, Wirsching P, Janda KD, Zorrilla EP, Koob GF. MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist. Pharmacology, Biochemistry, and Behavior. 88: 497-510. PMID 18031798 DOI: 10.1016/j.pbb.2007.10.008  0.819
2008 Specio SE, Wee S, O'Dell LE, Boutrel B, Zorrilla EP, Koob GF. CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats. Psychopharmacology. 196: 473-82. PMID 17965976 DOI: 10.1007/S00213-007-0983-9  0.826
2008 Wee S, Mandyam CD, Lekic DM, Koob GF. Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 18: 303-11. PMID 17920248 DOI: 10.1016/j.euroneuro.2007.08.003  0.693
2008 Walker BM, Koob GF. Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 643-52. PMID 17473837 DOI: 10.1038/sj.npp.1301438  0.682
2008 Boutrel B, de Lecea L, Koob G. S.03.05 Hypocretin/orexin in addiction: a mediator of stress-induced reinstatement of cocaine-seeking behaviour European Neuropsychopharmacology. 18: S160. DOI: 10.1016/S0924-977X(08)70127-5  0.692
2007 Caine SB, Thomsen M, Gabriel KI, Berkowitz JS, Gold LH, Koob GF, Tonegawa S, Zhang J, Xu M. Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 13140-50. PMID 18045908 DOI: 10.1523/Jneurosci.2284-07.2007  0.761
2007 Tabarin A, Diz-Chaves Y, Consoli D, Monsaingeon M, Bale TL, Culler MD, Datta R, Drago F, Vale WW, Koob GF, Zorrilla EP, Contarino A. Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis. The European Journal of Neuroscience. 26: 2303-14. PMID 17953621 DOI: 10.1111/j.1460-9568.2007.05856.x  0.794
2007 Mandyam CD, Wee S, Eisch AJ, Richardson HN, Koob GF. Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11442-50. PMID 17942739 DOI: 10.1523/JNEUROSCI.2505-07.2007  0.745
2007 George O, Ghozland S, Azar MR, Cottone P, Zorrilla EP, Parsons LH, O'Dell LE, Richardson HN, Koob GF. CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats. Proceedings of the National Academy of Sciences of the United States of America. 104: 17198-203. PMID 17921249 DOI: 10.1073/Pnas.0707585104  0.797
2007 Zhang Z, Morse AC, Koob GF, Schulteis G. Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in rats. Alcoholism, Clinical and Experimental Research. 31: 1811-9. PMID 17877783 DOI: 10.1111/j.1530-0277.2007.00483.x  0.336
2007 Koob G, Kreek MJ. Stress, dysregulation of drug reward pathways, and the transition to drug dependence. The American Journal of Psychiatry. 164: 1149-59. PMID 17671276 DOI: 10.1176/Appi.Ajp.2007.05030503  0.42
2007 Heilig M, Koob GF. A key role for corticotropin-releasing factor in alcohol dependence. Trends in Neurosciences. 30: 399-406. PMID 17629579 DOI: 10.1016/J.Tins.2007.06.006  0.659
2007 Treweek J, Wee S, Koob GF, Dickerson TJ, Janda KD. Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 11580-4. PMID 17592122 DOI: 10.1073/Pnas.0701328104  0.526
2007 Funk CK, Koob GF. A CRF(2) agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent rats. Brain Research. 1155: 172-8. PMID 17512918 DOI: 10.1016/j.brainres.2007.04.009  0.824
2007 Chu K, Koob GF, Cole M, Zorrilla EP, Roberts AJ. Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout. Pharmacology, Biochemistry, and Behavior. 86: 813-21. PMID 17482248 DOI: 10.1016/J.Pbb.2007.03.009  0.74
2007 Thorsell A, Repunte-Canonigo V, O'Dell LE, Chen SA, King AR, Lekic D, Koob GF, Sanna PP. Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats. Brain : a Journal of Neurology. 130: 1330-7. PMID 17405766 DOI: 10.1093/Brain/Awm033  0.73
2007 Brogan AP, Eubanks LM, Koob GF, Dickerson TJ, Janda KD. Antibody-catalyzed oxidation of delta(9)-tetrahydrocannabinol. Journal of the American Chemical Society. 129: 3698-702. PMID 17335216 DOI: 10.1021/Ja070022M  0.407
2007 Wee S, Wang Z, Woolverton WL, Pulvirenti L, Koob GF. Effect of aripiprazole, a partial dopamine D2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session duration. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 2238-47. PMID 17327886 DOI: 10.1038/Sj.Npp.1301353  0.438
2007 O'Dell LE, Koob GF. 'Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administration. Pharmacology, Biochemistry, and Behavior. 86: 346-53. PMID 17292952 DOI: 10.1016/J.Pbb.2007.01.004  0.652
2007 Walker BM, Koob GF. The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats. Alcoholism, Clinical and Experimental Research. 31: 11-8. PMID 17207096 DOI: 10.1111/j.1530-0277.2006.00259.x  0.661
2007 Wee S, Specio SE, Koob GF. Effects of dose and session duration on cocaine self-administration in rats. The Journal of Pharmacology and Experimental Therapeutics. 320: 1134-43. PMID 17202405 DOI: 10.1124/jpet.106.113340  0.383
2007 Le Moal M, Koob GF. Drug addiction: pathways to the disease and pathophysiological perspectives. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 17: 377-93. PMID 17169534 DOI: 10.1016/j.euroneuro.2006.10.006  0.519
2007 Solbrig MV, Adrian R, Wechsler SL, Koob GF. Activators of potassium M currents have anticonvulsant actions in two rat models of encephalitis. European Journal of Pharmacology. 555: 23-9. PMID 17126318 DOI: 10.1016/j.ejphar.2006.10.025  0.301
2007 O'Dell LE, Chen SA, Smith RT, Specio SE, Balster RL, Paterson NE, Markou A, Zorrilla EP, Koob GF. Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats. The Journal of Pharmacology and Experimental Therapeutics. 320: 180-93. PMID 17050784 DOI: 10.1124/Jpet.106.105270  0.802
2007 Fekete EM, Inoue K, Zhao Y, Rivier JE, Vale WW, Szücs A, Koob GF, Zorrilla EP. Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 1052-68. PMID 17019404 DOI: 10.1038/Sj.Npp.1301214  0.817
2007 Funk CK, Zorrilla EP, Lee MJ, Rice KC, Koob GF. Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats. Biological Psychiatry. 61: 78-86. PMID 16876134 DOI: 10.1016/J.Biopsych.2006.03.063  0.825
2006 Heinrichs SC, Koob GF. Application of experimental stressors in laboratory rodents. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit8.4. PMID 18428648 DOI: 10.1002/0471142301.ns0804s34  0.603
2006 Guillem K, Vouillac C, Azar MR, Parsons LH, Koob GF, Cador M, Stinus L. Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats. The European Journal of Neuroscience. 24: 3532-40. PMID 17229101 DOI: 10.1111/J.1460-9568.2006.05217.X  0.713
2006 Koob GF. A role for GABA in alcohol dependence. Advances in Pharmacology (San Diego, Calif.). 54: 205-29. PMID 17175816 DOI: 10.1016/S1054-3589(06)54009-8  0.351
2006 Eubanks LM, Rogers CJ, Beuscher AE, Koob GF, Olson AJ, Dickerson TJ, Janda KD. A molecular link between the active component of marijuana and Alzheimer's disease pathology. Molecular Pharmaceutics. 3: 773-7. PMID 17140265 DOI: 10.1021/Mp060066M  0.4
2006 Funk CK, O'Dell LE, Crawford EF, Koob GF. Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11324-32. PMID 17079660 DOI: 10.1523/Jneurosci.3096-06.2006  0.825
2006 Sabino V, Cottone P, Koob GF, Steardo L, Lee MJ, Rice KC, Zorrilla EP. Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats. Psychopharmacology. 189: 175-86. PMID 17047935 DOI: 10.1007/S00213-006-0546-5  0.818
2006 Crabbe JC, Phillips TJ, Harris RA, Arends MA, Koob GF. Alcohol-related genes: contributions from studies with genetically engineered mice. Addiction Biology. 11: 195-269. PMID 16961758 DOI: 10.1111/J.1369-1600.2006.00038.X  0.348
2006 Steffensen SC, Stobbs SH, Colago EE, Lee RS, Koob GF, Gallegos RA, Henriksen SJ. Contingent and non-contingent effects of heroin on mu-opioid receptor-containing ventral tegmental area GABA neurons. Experimental Neurology. 202: 139-51. PMID 16814775 DOI: 10.1016/j.expneurol.2006.05.023  0.588
2006 Kenny PJ, Chen SA, Kitamura O, Markou A, Koob GF. Conditioned withdrawal drives heroin consumption and decreases reward sensitivity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 5894-900. PMID 16738231 DOI: 10.1523/JNEUROSCI.0740-06.2006  0.794
2006 Hoefer ME, Voskanian SJ, Koob GF, Pulvirenti L. Effects of terguride, ropinirole, and acetyl-L-carnitine on methamphetamine withdrawal in the rat. Pharmacology, Biochemistry, and Behavior. 83: 403-9. PMID 16647107 DOI: 10.1016/j.pbb.2006.02.023  0.408
2006 Mulligan MK, Ponomarev I, Hitzemann RJ, Belknap JK, Tabakoff B, Harris RA, Crabbe JC, Blednov YA, Grahame NJ, Phillips TJ, Finn DA, Hoffman PL, Iyer VR, Koob GF, Bergeson SE. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proceedings of the National Academy of Sciences of the United States of America. 103: 6368-73. PMID 16618939 DOI: 10.1073/Pnas.0510188103  0.321
2006 O'Dell LE, Bruijnzeel AW, Smith RT, Parsons LH, Merves ML, Goldberger BA, Richardson HN, Koob GF, Markou A. Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction. Psychopharmacology. 186: 612-9. PMID 16598454 DOI: 10.1007/S00213-006-0383-6  0.781
2006 Kitamura O, Wee S, Specio SE, Koob GF, Pulvirenti L. Escalation of methamphetamine self-administration in rats: a dose-effect function. Psychopharmacology. 186: 48-53. PMID 16552556 DOI: 10.1007/s00213-006-0353-z  0.407
2006 Johnson BA, Koob GF, Schuckit MA, Mason BJ, Ait-Daoud N. Understanding and treating alcohol dependence. Alcoholism, Clinical and Experimental Research. 30: 567-84. PMID 16499499 DOI: 10.1111/J.1530-0277.2005.00066.X  0.32
2006 Chen SA, O'Dell LE, Hoefer ME, Greenwell TN, Zorrilla EP, Koob GF. Unlimited access to heroin self-administration: independent motivational markers of opiate dependence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 2692-707. PMID 16452993 DOI: 10.1038/Sj.Npp.1301008  0.809
2006 Chen SA, O'Dell LE, Hoefer ME, Greenwell TN, Zorrilla EP, Koob GF. Erratum: Unlimited Access to Heroin Self-Administration: Independent Motivational Markers of Opiate Dependence Neuropsychopharmacology. 31: 2802-2802. DOI: 10.1038/Sj.Npp.1301058  0.794
2005 Boutrel B, Kenny PJ, Specio SE, Martin-Fardon R, Markou A, Koob GF, de Lecea L. Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proceedings of the National Academy of Sciences of the United States of America. 102: 19168-73. PMID 16357203 DOI: 10.1073/Pnas.0507480102  0.828
2005 Qi L, Yamamoto N, Meijler MM, Altobell LJ, Koob GF, Wirsching P, Janda KD. Delta9-tetrahydrocannabinol immunochemical studies: haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta9-tetrahydrocannabinol. Journal of Medicinal Chemistry. 48: 7389-99. PMID 16279798 DOI: 10.1021/Jm050442R  0.439
2005 Koob GF, Le Moal M. Plasticity of reward neurocircuitry and the 'dark side' of drug addiction. Nature Neuroscience. 8: 1442-4. PMID 16251985 DOI: 10.1038/nn1105-1442  0.55
2005 Guillem K, Vouillac C, Azar MR, Parsons LH, Koob GF, Cador M, Stinus L. Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 8593-600. PMID 16177026 DOI: 10.1523/Jneurosci.2139-05.2005  0.71
2005 Sanchis-Segura C, Grisel JE, Olive MF, Ghozland S, Koob GF, Roberts AJ, Cowen MS. Role of the endogenous opioid system on the neuropsychopharmacological effects of ethanol: new insights about an old question. Alcoholism, Clinical and Experimental Research. 29: 1522-7. PMID 16156049 DOI: 10.1097/01.Alc.0000174913.60384.E8  0.351
2005 Ahmed SH, Lutjens R, van der Stap LD, Lekic D, Romano-Spica V, Morales M, Koob GF, Repunte-Canonigo V, Sanna PP. Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction. Proceedings of the National Academy of Sciences of the United States of America. 102: 11533-8. PMID 16076954 DOI: 10.1073/Pnas.0504438102  0.729
2005 Izzo E, Sanna PP, Koob GF. Impairment of dopaminergic system function after chronic treatment with corticotropin-releasing factor. Pharmacology, Biochemistry, and Behavior. 81: 701-8. PMID 16005056 DOI: 10.1016/j.pbb.2005.04.017  0.369
2005 De Witte P, Littleton J, Parot P, Koob G. Neuroprotective and abstinence-promoting effects of acamprosate: elucidating the mechanism of action. Cns Drugs. 19: 517-37. PMID 15963001 DOI: 10.2165/00023210-200519060-00004  0.387
2005 O'Dell LE, Purdy RH, Covey DF, Richardson HN, Roberto M, Koob GF. Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats. Pharmacology, Biochemistry, and Behavior. 81: 543-50. PMID 15950269 DOI: 10.1016/J.Pbb.2005.03.020  0.773
2005 Ahmed SH, Koob GF. Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function. Psychopharmacology. 180: 473-90. PMID 15731896 DOI: 10.1007/s00213-005-2180-z  0.633
2005 Breese GR, Chu K, Dayas CV, Funk D, Knapp DJ, Koob GF, Lê DA, O'Dell LE, Overstreet DH, Roberts AJ, Sinha R, Valdez GR, Weiss F. Stress enhancement of craving during sobriety: a risk for relapse. Alcoholism, Clinical and Experimental Research. 29: 185-95. PMID 15714042 DOI: 10.1097/01.Alc.0000153544.83656.3C  0.813
2005 Zorrilla EP, Inoue K, Fekete EM, Tabarin A, Valdez GR, Koob GF. Measuring meals: structure of prandial food and water intake of rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 288: R1450-67. PMID 15637168 DOI: 10.1152/ajpregu.00175.2004  0.793
2005 Zorrilla EP, Inoue K, Valdez GR, Tabarin A, Koob GF. Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat. Psychopharmacology. 177: 324-35. PMID 15609069 DOI: 10.1007/s00213-004-1952-1  0.707
2005 Kenny PJ, Boutrel B, Gasparini F, Koob GF, Markou A. Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats. Psychopharmacology. 179: 247-54. PMID 15602687 DOI: 10.1007/S00213-004-2069-2  0.824
2005 Stinus L, Cador M, Zorrilla EP, Koob GF. Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 90-8. PMID 15138444 DOI: 10.1038/Sj.Npp.1300487  0.759
2005 Ghozland S, Zorrilla E, Parsons L, Koob G. B63 EXTRACELLULAR CRF LEVELS IN THE CENTRAL NUCLEUS OF THE AMYGDALA AND ANXIETY-LIKE BEHAVIOR DURING NICOTINE WITHDRAWAL Behavioural Pharmacology. 16: S85-S86. DOI: 10.1097/00008877-200509001-00268  0.799
2005 Boutrel B, Kenny P, Specio S, Winsky-Sommerer R, Halfon O, Magistretti P, Markou A, Koob G, de Lecea L. A116 A KEY ROLE FOR HYPOCRETIN IN REGULATING BRAIN REWARD FUNCTION AND REINSTATEMENT FOR DRUG-SEEKING BEHAVIOR IN RATS Behavioural Pharmacology. 16: S60. DOI: 10.1097/00008877-200509001-00189  0.803
2005 Zorrilla EP, Koob GF. Chapter 2.4 The roles of urocortins 1, 2, and 3 in the brain Techniques in the Behavioral and Neural Sciences. 15: 179-203. DOI: 10.1016/S0921-0709(05)80013-6  0.732
2005 Monsaingeon M, Diz-Chaves Y, Zorrilla E, Kieffer B, Corcuff J, Roberts A, Koob G, Tabarin A. CO21 - Modulation du comportement alimentaire par le système opioïde endogène mu Annales D'Endocrinologie. 66: 398. DOI: 10.1016/S0003-4266(05)81822-0  0.7
2005 Koob GF. The neurocircuitry of addiction: Implications for treatment Clinical Neuroscience Research. 5: 89-101. DOI: 10.1016/j.cnr.2005.08.005  0.388
2005 Boutrel B, Kenny PJ, Markou A, Koob GF. Hypocretin and brain reward function Hypocretins: Integrators of Physiological Functions. 317-326. DOI: 10.1007/0-387-25446-3_21  0.77
2005 Valdez GR, Zorrilla EP, Koob GF. Homeostasis within the corticotropin-releasing factor system via CRF 2 receptor activation: A novel approach for the treatment of anxiety Drug Development Research. 65: 205-215. DOI: 10.1002/ddr.20024  0.719
2004 Valdez GR, Koob GF. Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide Y systems: implications for the development of alcoholism. Pharmacology, Biochemistry, and Behavior. 79: 671-89. PMID 15582675 DOI: 10.1016/j.pbb.2004.09.020  0.384
2004 O'Dell LE, Roberts AJ, Smith RT, Koob GF. Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure. Alcoholism, Clinical and Experimental Research. 28: 1676-82. PMID 15547454 DOI: 10.1097/01.Alc.0000145781.11923.4E  0.673
2004 Boutrel B, Koob GF. What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications. Sleep. 27: 1181-94. PMID 15532213 DOI: 10.1093/Sleep/27.6.1181  0.662
2004 Navarro M, Carrera MR, Del Arco I, Trigo JM, Koob GF, Rodríguez de Fonseca F. Cannabinoid receptor antagonist reduces heroin self-administration only in dependent rats. European Journal of Pharmacology. 501: 235-7. PMID 15464083 DOI: 10.1016/j.ejphar.2004.08.022  0.429
2004 Koob GF. A role for GABA mechanisms in the motivational effects of alcohol. Biochemical Pharmacology. 68: 1515-25. PMID 15451394 DOI: 10.1016/j.bcp.2004.07.031  0.363
2004 Koob GF, Greenwell TN. Neuropeptide S: a novel activating anxiolytic? Neuron. 43: 441-2. PMID 15312642 DOI: 10.1016/j.neuron.2004.08.007  0.782
2004 Heinrichs SC, Koob GF. Corticotropin-releasing factor in brain: a role in activation, arousal, and affect regulation. The Journal of Pharmacology and Experimental Therapeutics. 311: 427-40. PMID 15297468 DOI: 10.1124/jpet.103.052092  0.638
2004 Martin G, Guadaño-Ferraz A, Morte B, Ahmed S, Koob GF, De Lecea L, Siggins GR. Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens. The Journal of Pharmacology and Experimental Therapeutics. 311: 265-73. PMID 15263066 DOI: 10.1124/Jpet.104.067504  0.768
2004 O'Dell LE, Bruijnzeel AW, Ghozland S, Markou A, Koob GF. Nicotine withdrawal in adolescent and adult rats. Annals of the New York Academy of Sciences. 1021: 167-74. PMID 15251887 DOI: 10.1196/Annals.1308.022  0.748
2004 Carrera MR, Kaufmann GF, Mee JM, Meijler MM, Koob GF, Janda KD. Treating cocaine addiction with viruses. Proceedings of the National Academy of Sciences of the United States of America. 101: 10416-21. PMID 15226496 DOI: 10.1073/Pnas.0403795101  0.508
2004 Zorrilla EP, Koob GF. The therapeutic potential of CRF1 antagonists for anxiety. Expert Opinion On Investigational Drugs. 13: 799-828. PMID 15212620 DOI: 10.1517/13543784.13.7.799  0.732
2004 Valdez GR, Sabino V, Koob GF. Increased anxiety-like behavior and ethanol self-administration in dependent rats: reversal via corticotropin-releasing factor-2 receptor activation. Alcoholism, Clinical and Experimental Research. 28: 865-72. PMID 15201629 DOI: 10.1097/01.Alc.0000128222.29875.40  0.709
2004 Inoue K, Zorrilla EP, Tabarin A, Valdez GR, Iwasaki S, Kiriike N, Koob GF. Reduction of anxiety after restricted feeding in the rat: implication for eating disorders. Biological Psychiatry. 55: 1075-81. PMID 15158426 DOI: 10.1016/j.biopsych.2004.01.026  0.695
2004 Zorrilla EP, Reinhardt LE, Valdez GR, Inoue K, Rivier JE, Vale WW, Koob GF. Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity. The Journal of Pharmacology and Experimental Therapeutics. 310: 1027-34. PMID 15115804 DOI: 10.1124/jpet.104.068676  0.747
2004 Sanna PP, Koob GF. Cocaine's long run. Nature Medicine. 10: 340-1. PMID 15057223 DOI: 10.1038/nm0404-340  0.335
2004 Koob GF, Ahmed SH, Boutrel B, Chen SA, Kenny PJ, Markou A, O'Dell LE, Parsons LH, Sanna PP. Neurobiological mechanisms in the transition from drug use to drug dependence. Neuroscience and Biobehavioral Reviews. 27: 739-49. PMID 15019424 DOI: 10.1016/J.Neubiorev.2003.11.007  0.8
2004 Weed MR, Gold LH, Polis I, Koob GF, Fox HS, Taffe MA. Impaired performance on a rhesus monkey neuropsychological testing battery following simian immunodeficiency virus infection. Aids Research and Human Retroviruses. 20: 77-89. PMID 15000701 DOI: 10.1089/088922204322749521  0.776
2004 O'Dell LE, Alomary AA, Vallée M, Koob GF, Fitzgerald RL, Purdy RH. Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats. European Journal of Pharmacology. 484: 241-7. PMID 14744609 DOI: 10.1016/J.Ejphar.2003.11.031  0.671
2004 Carrera MR, Ashley JA, Hoffman TZ, Isomura S, Wirsching P, Koob GF, Janda KD. Investigations using immunization to attenuate the psychoactive effects of nicotine. Bioorganic & Medicinal Chemistry. 12: 563-70. PMID 14738965 DOI: 10.1016/J.Bmc.2003.11.029  0.48
2004 Ahmed SH, Koob GF. Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake. Psychopharmacology. 172: 450-4. PMID 14647962 DOI: 10.1007/s00213-003-1682-9  0.684
2004 Ben-Shahar O, Ahmed SH, Koob GF, Ettenberg A. The transition from controlled to compulsive drug use is associated with a loss of sensitization. Brain Research. 995: 46-54. PMID 14644470 DOI: 10.1016/j.brainres.2003.09.053  0.82
2004 Tabarin A, DizChavez Y, Catargi B, Roberts A, Zorrilla E, Redonnet A, Coscina D, Inoue K, Kieffer B, Koob G. CO05 - Récepteur mu des opioïdes endogènes : une nouvelle cible dans le traitement de l’obésité ? Annales D'Endocrinologie. 65: 249. DOI: 10.1016/S0003-4266(04)95686-7  0.631
2004 Koob GF, Ahmed SH. Vertical shifts in dose?injection curves reflect reward allostasis, not sensitization Psychopharmacology. 171: 354-355. DOI: 10.1007/s00213-003-1603-y  0.631
2003 Kenny PJ, Paterson NE, Boutrel B, Semenova S, Harrison AA, Gasparini F, Koob GF, Skoubis PD, Markou A. Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats. Annals of the New York Academy of Sciences. 1003: 415-8. PMID 14684476 DOI: 10.1196/Annals.1300.040  0.821
2003 Koob GF. Neuroadaptive mechanisms of addiction: studies on the extended amygdala. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 13: 442-52. PMID 14636960 DOI: 10.1016/j.euroneuro.2003.08.005  0.4
2003 Kenny PJ, Koob GF, Markou A. Conditioned facilitation of brain reward function after repeated cocaine administration. Behavioral Neuroscience. 117: 1103-7. PMID 14570559 DOI: 10.1037/0735-7044.117.5.1103  0.727
2003 Vallée M, Purdy RH, Mayo W, Koob GF, Le Moal M. Neuroactive steroids: new biomarkers of cognitive aging. The Journal of Steroid Biochemistry and Molecular Biology. 85: 329-35. PMID 12943719 DOI: 10.1016/S0960-0760(03)00227-9  0.681
2003 Zorrilla EP, Taché Y, Koob GF. Nibbling at CRF receptor control of feeding and gastrocolonic motility. Trends in Pharmacological Sciences. 24: 421-7. PMID 12915052 DOI: 10.1016/S0165-6147(03)00177-9  0.727
2003 Walker JR, Chen SA, Moffitt H, Inturrisi CE, Koob GF. Chronic opioid exposure produces increased heroin self-administration in rats. Pharmacology, Biochemistry, and Behavior. 75: 349-54. PMID 12873626 DOI: 10.1016/S0091-3057(03)00094-7  0.557
2003 Valdez GR, Zorrilla EP, Rivier J, Vale WW, Koob GF. Locomotor suppressive and anxiolytic-like effects of urocortin 3, a highly selective type 2 corticotropin-releasing factor agonist. Brain Research. 980: 206-12. PMID 12867260 DOI: 10.1016/S0006-8993(03)02971-8  0.749
2003 Ahmed SH, Lin D, Koob GF, Parsons LH. Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels. Journal of Neurochemistry. 86: 102-13. PMID 12807430 DOI: 10.1046/J.1471-4159.2003.01833.X  0.817
2003 Valdez GR, Zorrilla EP, Roberts AJ, Koob GF. Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence. Alcohol (Fayetteville, N.Y.). 29: 55-60. PMID 12782246 DOI: 10.1016/S0741-8329(03)00020-X  0.758
2003 Heyser CJ, Moc K, Koob GF. Effects of naltrexone alone and in combination with acamprosate on the alcohol deprivation effect in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1463-71. PMID 12700689 DOI: 10.1038/sj.npp.1300175  0.418
2003 Inoue K, Valdez GR, Reyes TM, Reinhardt LE, Tabarin A, Rivier J, Vale WW, Sawchenko PE, Koob GF, Zorrilla EP. Human urocortin II, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat. The Journal of Pharmacology and Experimental Therapeutics. 305: 385-93. PMID 12649393 DOI: 10.1124/Jpet.102.047712  0.74
2003 Koob GF, Roberts AJ, Kieffer BL, Heyser CJ, Katner SN, Ciccocioppo R, Weiss F. Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology. Recent Developments in Alcoholism : An Official Publication of the American Medical Society On Alcoholism, the Research Society On Alcoholism, and the National Council On Alcoholism. 16: 263-81. PMID 12638642  0.811
2003 Koob GF. Alcoholism: allostasis and beyond. Alcoholism, Clinical and Experimental Research. 27: 232-43. PMID 12605072 DOI: 10.1097/01.ALC.0000057122.36127.C2  0.397
2003 Caillé S, Stinus L, Espejo EF, De Deurwaerdère P, Spampinato U, Koob GF. Inhibition of 5-HT neurotransmission increases clonidine protective effects on naloxone-induced conditioned place aversion in morphine-dependent rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 276-83. PMID 12589380 DOI: 10.1038/sj.npp.1300033  0.341
2003 Alomary AA, Vallée M, O'Dell LE, Koob GF, Purdy RH, Fitzgerald RL. Acutely administered ethanol participates in testosterone synthesis and increases testosterone in rat brain. Alcoholism, Clinical and Experimental Research. 27: 38-43. PMID 12544003 DOI: 10.1097/01.ALC.0000047304.28550.4F  0.643
2003 Kenny PJ, Polis I, Koob GF, Markou A. Low dose cocaine self-administration transiently increases but high dose cocaine persistently decreases brain reward function in rats. The European Journal of Neuroscience. 17: 191-5. PMID 12534985 DOI: 10.1046/j.1460-9568.2003.02443.x  0.735
2003 Alomary AA, Vallee M, O'Dell LE, Koob GF, Purdy RH, Fitzgerald RL. Acutely Administered Ethanol Participates in Testosterone Synthesis and Increases Testosterone in Rat Brain Alcoholism: Clinical and Experimental Research. 27: 38-43. DOI: 10.1111/J.1530-0277.2003.Tb02718.X  0.678
2003 Zorrilla E, Fekete E, Mason B, Wirsching P, Janda K, Koob G. S.13.01 CRF1 antagonists for anxiety European Neuropsychopharmacology. 13: S130-S131. DOI: 10.1016/S0924-977X(03)91650-6  0.695
2002 Izzo E, Martin-Fardon R, Koob GF, Weiss F, Sanna PP. Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization. Nature Neuroscience. 5: 1263-4. PMID 12436114 DOI: 10.1038/Nn977  0.63
2002 Solbrig MV, Koob GF, Lipkin WI. Key role for enkephalinergic tone in cortico-striatal-thalamic function. The European Journal of Neuroscience. 16: 1819-22. PMID 12431235 DOI: 10.1046/j.1460-9568.2002.02240.x  0.306
2002 Valdez GR, Roberts AJ, Chan K, Davis H, Brennan M, Zorrilla EP, Koob GF. Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor. Alcoholism, Clinical and Experimental Research. 26: 1494-501. PMID 12394282 DOI: 10.1111/J.1530-0277.2002.Tb02448.X  0.761
2002 Sanna PP, Simpson C, Lutjens R, Koob G. ERK regulation in chronic ethanol exposure and withdrawal. Brain Research. 948: 186-91. PMID 12383974 DOI: 10.1016/S0006-8993(02)03191-8  0.338
2002 Zorrilla EP, Schulteis G, Ormsby A, Klaassen A, Ling N, McCarthy JR, Koob GF, De Souza EB. Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors. Brain Research. 952: 200-10. PMID 12376180 DOI: 10.1016/S0006-8993(02)03345-0  0.722
2002 Zorrilla EP, Valdez GR, Nozulak J, Koob GF, Markou A. Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. Brain Research. 952: 188-99. PMID 12376179 DOI: 10.1016/S0006-8993(02)03189-X  0.802
2002 Contarino A, Picetti R, Matthes HW, Koob GF, Kieffer BL, Gold LH. Lack of reward and locomotor stimulation induced by heroin in mu-opioid receptor-deficient mice. European Journal of Pharmacology. 446: 103-9. PMID 12098591 DOI: 10.1016/S0014-2999(02)01812-5  0.791
2002 Walker JR, Terenius L, Koob GF. Conditioned opioid withdrawal decreases nociceptin/orphanin FQ levels in the frontal cortex and olfactory tubercle. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 27: 203-11. PMID 12093594 DOI: 10.1016/S0893-133X(02)00292-0  0.391
2002 Vetter DE, Li C, Zhao L, Contarino A, Liberman MC, Smith GW, Marchuk Y, Koob GF, Heinemann SF, Vale W, Lee KF. Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior. Nature Genetics. 31: 363-9. PMID 12091910 DOI: 10.1038/Ng914  0.678
2002 Valdez GR, Inoue K, Koob GF, Rivier J, Vale W, Zorrilla EP. Human urocortin II: mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide. Brain Research. 943: 142-50. PMID 12088848 DOI: 10.1016/S0006-8993(02)02707-5  0.707
2002 Caillé S, Espejo EF, Koob GF, Stinus L. Dorsal and median raphe serotonergic system lesion does not alter the opiate withdrawal syndrome. Pharmacology, Biochemistry, and Behavior. 72: 979-86. PMID 12062589 DOI: 10.1016/S0091-3057(02)00810-9  0.344
2002 Ahmed SH, Kenny PJ, Koob GF, Markou A. Neurobiological evidence for hedonic allostasis associated with escalating cocaine use. Nature Neuroscience. 5: 625-6. PMID 12055635 DOI: 10.1038/nn872  0.81
2002 Ryabinin AE, Bachtell RK, Heinrichs SC, Lee S, Rivier C, Olive MF, Mehmert KK, Camarini R, Kim JA, Koenig HN, Nannini MA, Hodge CW, Roberts AJ, Koob GF. The corticotropin-releasing factor/urocortin system and alcohol. Alcoholism, Clinical and Experimental Research. 26: 714-22. PMID 12045481 DOI: 10.1111/J.1530-0277.2002.Tb02596.X  0.736
2002 Koob GF, Mason BJ, De Witte P, Littleton J, Siggins GR. Potential neuroprotective effects of acamprosate. Alcoholism, Clinical and Experimental Research. 26: 586-92. PMID 11981137  0.54
2002 Hungund BL, Basavarajappa BS, Vadasz C, Kunos G, Rodriguez de Fonseca F, Colombo G, Serra S, Parsons L, Koob GF. Ethanol, endocannabinoids, and the cannabinoidergic signaling system. Alcoholism, Clinical and Experimental Research. 26: 565-74. PMID 11981134  0.727
2002 Pulvirenti L, Koob GF. Being partial to psychostimulant addiction therapy. Trends in Pharmacological Sciences. 23: 151-3. PMID 11931978 DOI: 10.1016/S0165-6147(00)01991-X  0.358
2002 Orsini C, Izzo E, Koob GF, Pulvirenti L. Blockade of nitric oxide synthesis reduces responding for cocaine self-administration during extinction and reinstatement. Brain Research. 925: 133-40. PMID 11792361 DOI: 10.1016/S0006-8993(01)03267-X  0.393
2002 Bale TL, Picetti R, Contarino A, Koob GF, Vale WW, Lee KF. Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 193-9. PMID 11756502  0.656
2002 Bale TL, Picetti R, Contarino A, Koob GF, Vale WW, Lee K. Mice Deficient for Both Corticotropin-Releasing Factor Receptor 1 (CRFR1) and CRFR2 Have an Impaired Stress Response and Display Sexually Dichotomous Anxiety-Like Behavior The Journal of Neuroscience. 22: 193-199. DOI: 10.1523/Jneurosci.22-01-00193.2002  0.682
2002 Koob GF, Mason BJ, Witte P, Littleton J, Siggins GR. Potential Neuroprotective Effects of Acamprosate Alcoholism: Clinical and Experimental Research. 26: 586-592. DOI: 10.1111/J.1530-0277.2002.Tb02578.X  0.586
2002 Hungund BL, Basavarajappa BS, Vadasz C, Kunos G, Rodriguez de Fonseca F, Colombo G, Serra S, Parsons L, Koob GF. Ethanol, Endocannabinoids, and the Cannabinoidergic Signaling System Alcoholism: Clinical and Experimental Research. 26: 565-574. DOI: 10.1111/J.1530-0277.2002.Tb02575.X  0.746
2001 Weiss F, Koob GF. Drug addiction: functional neurotoxicity of the brain reward systems. Neurotoxicity Research. 3: 145-56. PMID 15111266 DOI: 10.1007/Bf03033235  0.627
2001 Vallée M, Shen W, Heinrichs SC, Zorumski CF, Covey DF, Koob GF, Purdy RH. Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats. The European Journal of Neuroscience. 14: 2003-10. PMID 11860495 DOI: 10.1046/J.0953-816X.2001.01817.X  0.605
2001 Orsini C, Koob GF, Pulvirenti L. Dopamine partial agonist reverses amphetamine withdrawal in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 25: 789-92. PMID 11682262 DOI: 10.1016/S0893-133X(01)00270-6  0.39
2001 Vallée M, Mayo W, Koob GF, Le Moal M. Neurosteroids in learning and memory processes. International Review of Neurobiology. 46: 273-320. PMID 11599303 DOI: 10.1016/S0074-7742(01)46066-1  0.676
2001 Currie PJ, Coscina DV, Bishop C, Coiro CD, Koob GF, Rivier J, Vale W. Hypothalamic paraventricular nucleus injections of urocortin alter food intake and respiratory quotient. Brain Research. 916: 222-8. PMID 11597609 DOI: 10.1016/S0006-8993(01)02851-7  0.335
2001 Roberts AJ, Gold LH, Polis I, McDonald JS, Filliol D, Kieffer BL, Koob GF. Increased ethanol self-administration in delta-opioid receptor knockout mice. Alcoholism, Clinical and Experimental Research. 25: 1249-56. PMID 11584142 DOI: 10.1111/J.1530-0277.2001.Tb02344.X  0.673
2001 Izzo E, Orsini C, Koob GF, Pulvirenti L. A dopamine partial agonist and antagonist block amphetamine self-administration in a progressive ratio schedule. Pharmacology, Biochemistry, and Behavior. 68: 701-8. PMID 11526967 DOI: 10.1016/S0091-3057(01)00472-5  0.369
2001 Navarro M, Carrera MR, Fratta W, Valverde O, Cossu G, Fattore L, Chowen JA, Gomez R, del Arco I, Villanua MA, Maldonado R, Koob GF, Rodriguez de Fonseca F. Functional interaction between opioid and cannabinoid receptors in drug self-administration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5344-50. PMID 11438610 DOI: 10.1523/Jneurosci.21-14-05344.2001  0.406
2001 Lê AD, Kiianmaa K, Cunningham CL, Engel JA, Ericson M, Söderpalm B, Koob GF, Roberts AJ, Weiss F, Hyytiä P, Janhunen S, Mikkola J, Bäckström P, Ponomarev I, Crabbe JC. Neurobiological processes in alcohol addiction. Alcoholism, Clinical and Experimental Research. 25: 144S-151S. PMID 11391064 DOI: 10.1111/J.1530-0277.2001.Tb02389.X  0.636
2001 Zorrilla EP, Schulteis G, Ling N, Koob GF, De Souza EB. Performance-enhancing effects of CRF-BP ligand inhibitors. Neuroreport. 12: 1231-4. PMID 11338197 DOI: 10.1097/00001756-200105080-00035  0.71
2001 Macey DJ, Froestl W, Koob GF, Markou A. Both GABA(B) receptor agonist and antagonists decreased brain stimulation reward in the rat. Neuropharmacology. 40: 676-85. PMID 11311895 DOI: 10.1016/S0028-3908(00)00204-5  0.611
2001 Carrera MR, Ashley JA, Wirsching P, Koob GF, Janda KD. A second-generation vaccine protects against the psychoactive effects of cocaine. Proceedings of the National Academy of Sciences of the United States of America. 98: 1988-92. PMID 11172063 DOI: 10.1073/Pnas.98.4.1988  0.525
2001 David V, Gold LH, Koob GF, Cazala P. Anxiogenic-like effects limit rewarding effects of cocaine in balb/cbyj mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 24: 300-18. PMID 11166520 DOI: 10.1016/S0893-133X(00)00205-0  0.599
2001 Gracy KN, Dankiewicz LA, Koob GF. Opiate withdrawal-induced fos immunoreactivity in the rat extended amygdala parallels the development of conditioned place aversion. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 24: 152-60. PMID 11120397 DOI: 10.1016/S0893-133X(00)00186-X  0.807
2001 Koob GF, Le Moal M. Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 24: 97-129. PMID 11120394 DOI: 10.1016/S0893-133X(00)00195-0  0.567
2001 Heinrichs SC, Koob GF. UNIT 8.4 Application of Experimental Stressors in Laboratory Rodents Current Protocols in Protein Science. DOI: 10.1002/0471142301.Ns0804S00  0.611
2000 Contarino A, Dellu FO, Koob GF, Smith GW, Lee K, Vale WW, Gold LH. Dissociation of Locomotor Activation and Suppression of Food Intake Induced by CRF in CRFR1-Deficient Mice. Endocrinology. 141: 2698-2702. PMID 28200977 DOI: 10.1210/endo.141.7.7653  0.717
2000 Morse AC, Schulteis G, Holloway FA, Koob GF. Conditioned place aversion to the "hangover" phase of acute ethanol administration in the rat. Alcohol (Fayetteville, N.Y.). 22: 19-24. PMID 11109024 DOI: 10.1016/S0741-8329(00)00099-9  0.342
2000 Watkins SS, Koob GF, Markou A. Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 2: 19-37. PMID 11072438 DOI: 10.1080/14622200050011277  0.63
2000 Koob GF. Animal models of craving for ethanol. Addiction (Abingdon, England). 95: S73-81. PMID 11002904 DOI: 10.1080/09652140050111663  0.404
2000 Smith AD, Smith DL, Zigmond MJ, Amalric M, Koob GF. Differential effects of dopamine receptor subtype blockade on performance of rats in a reaction-time paradigm. Psychopharmacology. 148: 355-60. PMID 10928307 DOI: 10.1007/s002130050063  0.504
2000 Koob GF. Neurobiology of addiction. Toward the development of new therapies. Annals of the New York Academy of Sciences. 909: 170-85. PMID 10911930 DOI: 10.1111/j.1749-6632.2000.tb06682.x  0.381
2000 Schulteis G, Ahmed SH, Morse AC, Koob GF, Everitt BJ. Conditioning and opiate withdrawal. Nature. 405: 1013-4. PMID 10890431 DOI: 10.1038/35016630  0.705
2000 Contarino A, Dellu F, Koob GF, Smith GW, Lee KF, Vale WW, Gold LH. Dissociation of locomotor activation and suppression of food intake induced by CRF in CRFR1-deficient mice. Endocrinology. 141: 2698-702. PMID 10875276 DOI: 10.1210/endo.141.7.7653  0.753
2000 Macey DJ, Koob GF, Markou A. CRF and urocortin decreased brain stimulation reward in the rat: reversal by a CRF receptor antagonist. Brain Research. 866: 82-91. PMID 10825483 DOI: 10.1016/S0006-8993(00)02229-0  0.655
2000 Carrera MR, Ashley JA, Zhou B, Wirsching P, Koob GF, Janda KD. Cocaine vaccines: antibody protection against relapse in a rat model. Proceedings of the National Academy of Sciences of the United States of America. 97: 6202-6. PMID 10823960 DOI: 10.1073/Pnas.97.11.6202  0.53
2000 Stinus L, Caille S, Koob GF. Opiate withdrawal-induced place aversion lasts for up to 16 weeks. Psychopharmacology. 149: 115-20. PMID 10805605 DOI: 10.1007/s002139900358  0.365
2000 Roberts AJ, Heyser CJ, Cole M, Griffin P, Koob GF. Excessive ethanol drinking following a history of dependence: animal model of allostasis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 22: 581-94. PMID 10788758 DOI: 10.1016/S0893-133X(99)00167-0  0.392
2000 Walker JR, Ahmed SH, Gracy KN, Koob GF. Microinjections of an opiate receptor antagonist into the bed nucleus of the stria terminalis suppress heroin self-administration in dependent rats. Brain Research. 854: 85-92. PMID 10784110 DOI: 10.1016/S0006-8993(99)02288-X  0.831
2000 Bale TL, Contarino A, Smith GW, Chan R, Gold LH, Sawchenko PE, Koob GF, Vale WW, Lee KF. Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nature Genetics. 24: 410-4. PMID 10742108 DOI: 10.1038/74263  0.751
2000 Britton KT, Akwa Y, Spina MG, Koob GF. Neuropeptide Y blocks anxiogenic-like behavioral action of corticotropin-releasing factor in an operant conflict test and elevated plus maze. Peptides. 21: 37-44. PMID 10704717 DOI: 10.1016/S0196-9781(99)00169-2  0.395
2000 Ahmed SH, Walker JR, Koob GF. Persistent increase in the motivation to take heroin in rats with a history of drug escalation. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 22: 413-21. PMID 10700660 DOI: 10.1016/S0893-133X(99)00133-5  0.697
2000 Spina MG, Basso AM, Zorrilla EP, Heyser CJ, Rivier J, Vale W, Merlo-Pich E, Koob GF. Behavioral effects of central administration of the novel CRF antagonist astressin in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 22: 230-9. PMID 10693150 DOI: 10.1016/S0893-133X(99)00108-6  0.749
2000 Dellu F, Contarino A, Simon H, Koob GF, Gold LH. Genetic differences in response to novelty and spatial memory using a two-trial recognition task in mice. Neurobiology of Learning and Memory. 73: 31-48. PMID 10686122 DOI: 10.1006/Nlme.1999.3919  0.72
2000 Gracy KN, Dankiewicz LA, Weiss F, Koob GF. Heroin-specific stimuli reinstate operant heroin-seeking behavior in rats after prolonged extinction. Pharmacology, Biochemistry, and Behavior. 65: 489-94. PMID 10683489 DOI: 10.1016/S0091-3057(99)00234-8  0.803
2000 Lin D, Koob GF, Markou A. Time-dependent alterations in ICSS thresholds associated with repeated amphetamine administrations. Pharmacology, Biochemistry, and Behavior. 65: 407-17. PMID 10683480 DOI: 10.1016/S0091-3057(99)00213-0  0.71
2000 Akwa Y, Purdy RH, Koob GF, Britton KT. The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat. Behavioural Brain Research. 106: 119-25. PMID 10595427 DOI: 10.1016/S0166-4328(99)00101-1  0.351
2000 Solbrig MV, Koob GF, Parsons LH, Kadota T, Horscroft N, Briese T, Lipkin WI. Neurotrophic Factor Expression After CNS Viral Injury Produces Enhanced Sensitivity to Psychostimulants: Potential Mechanism for Addiction Vulnerability The Journal of Neuroscience. 20: RC104-RC104. DOI: 10.1523/Jneurosci.20-21-J0002.2000  0.735
2000 Richter RM, Zorrilla EP, Basso AM, Koob GF, Weiss F. Altered Amygdalar CRF Release and Increased Anxiety-Like Behavior in Sardinian Alcohol-Preferring Rats: A Microdialysis and Behavioral Study Alcoholism: Clinical and Experimental Research. 24: 1765-1772. DOI: 10.1111/J.1530-0277.2000.Tb01979.X  0.801
1999 Koob GF. Stress, corticotropin-releasing factor, and drug addiction Annals of the New York Academy of Sciences. 897: 27-45. PMID 10676433 DOI: 10.1111/j.1749-6632.1999.tb07876.x  0.394
1999 Koob GF, Heinrichs SC. A role for corticotropin releasing factor and urocortin in behavioral responses to stressors. Brain Research. 848: 141-52. PMID 10612706 DOI: 10.1016/S0006-8993(99)01991-5  0.678
1999 Koob GF. Cocaine reward and dopamine receptors: Love at first site Archives of General Psychiatry. 56: 1107-1108. PMID 10591287 DOI: 10.1001/ARCHPSYC.56.12.1107  0.344
1999 Walker JR, King M, Izzo E, Koob GF, Pasternak GW. Antagonism of heroin and morphine self-administration in rats by the morphine-6β-glucuronide antagonist 3-O-methylnaltrexone European Journal of Pharmacology. 383: 115-119. PMID 10585524 DOI: 10.1016/S0014-2999(99)00633-0  0.323
1999 Koob GF. Corticotropin-releasing factor, norepinephrine, and stress Biological Psychiatry. 46: 1167-1180. PMID 10560023 DOI: 10.1016/S0006-3223(99)00164-X  0.38
1999 Weed MR, Taffe MA, Polis I, Roberts AC, Robbins TW, Koob GF, Bloom FE, Gold LH. Performance norms for a rhesus monkey neuropsychological testing battery: acquisition and long-term performance. Brain Research. Cognitive Brain Research. 8: 185-201. PMID 10556598 DOI: 10.1016/S0926-6410(99)00020-8  0.78
1999 Ahmed SH, Koob GF. Long-lasting increase in the set point for cocaine self-administration after escalation in rats. Psychopharmacology. 146: 303-12. PMID 10541731 DOI: 10.1007/s002130051121  0.684
1999 Lin D, Koob GF, Markou A. Differential effects of withdrawal from chronic amphetamine or fluoxetine administration on brain stimulation reward in the rat--interactions between the two drugs. Psychopharmacology. 145: 283-94. PMID 10494577 DOI: 10.1007/S002130051060  0.712
1999 Contarino A, Dellu F, Koob GF, Smith GW, Lee KF, Vale W, Gold LH. Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1. Brain Research. 835: 1-9. PMID 10448190 DOI: 10.1016/S0006-8993(98)01158-5  0.741
1999 Basso AM, Spina M, Rivier J, Vale W, Koob GF. Corticotropin-releasing factor antagonist attenuates the "anxiogenic-like" effect in the defensive burying paradigm but not in the elevated plus-maze following chronic cocaine in rats. Psychopharmacology. 145: 21-30. PMID 10445369 DOI: 10.1007/s002130051028  0.444
1999 Koob GF. The role of the striatopallidal and extended amygdala systems in drug addiction Annals of the New York Academy of Sciences. 877: 445-460. PMID 10415664 DOI: 10.1111/j.1749-6632.1999.tb09282.x  0.447
1999 Carrera MR, Schulteis G, Koob GF. Heroin self-administration in dependent Wistar rats: increased sensitivity to naloxone. Psychopharmacology. 144: 111-20. PMID 10394991 DOI: 10.1007/s002130050983  0.402
1999 Lee RS, Criado JR, Koob GF, Henriksen SJ. Cellular responses of nucleus accumbens neurons to opiate-seeking behavior: I. Sustained responding during heroin self-administration. Synapse (New York, N.Y.). 33: 49-58. PMID 10380850 DOI: 10.1002/(SICI)1098-2396(199907)33:1<49::AID-SYN5>3.0.CO;2-O  0.63
1999 Criado JR, Li H, Jiang X, Spina M, Huitrón-Reséndiz S, Liapakis G, Calbet M, Siehler S, Henriksen SJ, Koob G, Hoyer D, Sutcliffe JG, Goodman M, de Lecea L. Structural and compositional determinants of cortistatin activity. Journal of Neuroscience Research. 56: 611-9. PMID 10374816 DOI: 10.1002/(Sici)1097-4547(19990615)56:6<611::Aid-Jnr7>3.0.Co;2-G  0.669
1999 Parsons LH, Koob GF, Weiss F. RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine. Synapse (New York, N.Y.). 32: 132-5. PMID 10231132 DOI: 10.1002/(Sici)1098-2396(199905)32:2<132::Aid-Syn6>3.0.Co;2-V  0.788
1999 Watkins SS, Epping-Jordan MP, Koob GF, Markou A. Blockade of nicotine self-administration with nicotinic antagonists in rats. Pharmacology, Biochemistry, and Behavior. 62: 743-51. PMID 10208381 DOI: 10.1016/S0091-3057(98)00226-3  0.634
1999 Baldo BA, Jain K, Veraldi L, Koob GF, Markou A. A dopamine D1 agonist elevates self-stimulation thresholds: comparison to other dopamine-selective drugs. Pharmacology, Biochemistry, and Behavior. 62: 659-72. PMID 10208371 DOI: 10.1016/S0091-3057(98)00206-8  0.703
1999 Harrison AA, Parsons LH, Koob GF, Markou A. RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist. Psychopharmacology. 141: 242-50. PMID 10027505 DOI: 10.1007/S002130050831  0.799
1999 Baldo BA, Markou A, Koob GF. Increased sensitivity to the locomotor depressant effect of a dopamine receptor antagonist during cocaine withdrawal in the rat. Psychopharmacology. 141: 135-44. PMID 9952037 DOI: 10.1007/s002130050817  0.725
1999 Baldo BA, Koob GF, Markou A. Role of Adenosine A2 Receptors in Brain Stimulation Reward under Baseline Conditions and during Cocaine Withdrawal in Rats The Journal of Neuroscience. 19: 11017-11026. DOI: 10.1523/JNEUROSCI.19-24-11017.1999  0.737
1999 Martin G, Ahmed SH, Blank T, Spiess J, Koob GF, Siggins GR. Chronic Morphine Treatment Alters NMDA Receptor-Mediated Synaptic Transmission in the Nucleus Accumbens The Journal of Neuroscience. 19: 9081-9089. DOI: 10.1523/Jneurosci.19-20-09081.1999  0.578
1999 Heyser CJ, Roberts AJ, Schulteis G, Koob GF. Central Administration of an Opiate Antagonist Decreases Oral Ethanol Self-Administration in Rats Alcoholism: Clinical and Experimental Research. 23: 1468-1476. DOI: 10.1111/J.1530-0277.1999.TB04669.X  0.449
1999 Roberts AJ, Heyser CJ, Koob GF. Operant Self-Administration of Sweetened Versus Unsweetened Ethanol: Effects on Blood Alcohol Levels Alcoholism: Clinical and Experimental Research. 23: 1151-1157. DOI: 10.1111/J.1530-0277.1999.TB04272.X  0.357
1999 Koob GF, Roberts AJ. Brain Reward Circuits in Alcoholism Cns Spectrums. 4: 23-37. DOI: 10.1017/S1092852900011196  0.382
1998 Kosten TR, Markou A, Koob GF. Depression and stimulant dependence: neurobiology and pharmacotherapy. The Journal of Nervous and Mental Disease. 186: 737-45. PMID 9865811 DOI: 10.1097/00005053-199812000-00001  0.606
1998 Navarro M, Chowen J, Rocío A Carrera M, Del Arco L, Villanúa MA, Martin Y, Roberts AJ, Koob GF, Rodriguez De Fonseca F. CB1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats Neuroreport. 9: 3397-3402. PMID 9855288 DOI: 10.1097/00001756-199810260-00012  0.402
1998 Kimes AS, Maldonado R, Ambrosio E, Koob GF, London ED. Cerebral glucose metabolism during opioid withdrawal following methylnaloxonium injection into the locus coeruleus. Brain Research. 814: 1-12. PMID 9838021 DOI: 10.1016/S0006-8993(98)00813-0  0.326
1998 Schulteis G, Stinus L, Risbrough VB, Koob GF. Clonidine blocks acquisition but not expression of conditioned opiate withdrawal in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 19: 406-16. PMID 9778662 DOI: 10.1016/S0893-133X(98)00036-0  0.358
1998 Koob GF, Sanna PP, Bloom FE. Neuroscience of addiction. Neuron. 21: 467-76. PMID 9768834 DOI: 10.1016/S0896-6273(00)80557-7  0.605
1998 Ahmed SH, Koob GF. Transition from moderate to excessive drug intake: change in hedonic set point. Science (New York, N.Y.). 282: 298-300. PMID 9765157 DOI: 10.1126/science.282.5387.298  0.669
1998 Eckardt MJ, File SE, Gessa GL, Grant KA, Guerri C, Hoffman PL, Kalant H, Koob GF, Li TK, Tabakoff B. Effects of moderate alcohol consumption on the central nervous system. Alcoholism, Clinical and Experimental Research. 22: 998-1040. PMID 9726269 DOI: 10.1111/J.1530-0277.1998.Tb03695.X  0.349
1998 Kreek MJ, Koob GF. Drug dependence: stress and dysregulation of brain reward pathways. Drug and Alcohol Dependence. 51: 23-47. PMID 9716928 DOI: 10.1016/S0376-8716(98)00064-7  0.352
1998 Walker JR, Spina M, Terenius L, Koob GF. Nociceptin fails to affect heroin self-administration in the rat. Neuroreport. 9: 2243-7. PMID 9694207 DOI: 10.1097/00001756-199807130-00017  0.374
1998 Schulteis G, Yackey M, Risbrough V, Koob GF. Anxiogenic-like effects of spontaneous and naloxone-precipitated opiate withdrawal in the elevated plus-maze. Pharmacology, Biochemistry, and Behavior. 60: 727-31. PMID 9678657 DOI: 10.1016/S0091-3057(98)00034-3  0.385
1998 Lee RS, Koob GF, Henriksen SJ. Electrophysiological responses of nucleus accumbens neurons to novelty stimuli and exploratory behavior in the awake, unrestrained rat. Brain Research. 799: 317-22. PMID 9675326 DOI: 10.1016/S0006-8993(98)00477-6  0.591
1998 Smith GW, Aubry JM, Dellu F, Contarino A, Bilezikjian LM, Gold LH, Chen R, Marchuk Y, Hauser C, Bentley CA, Sawchenko PE, Koob GF, Vale W, Lee KF. Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron. 20: 1093-102. PMID 9655498 DOI: 10.1016/S0896-6273(00)80491-2  0.749
1998 Raber J, Sorg O, Horn TF, Yu N, Koob GF, Campbell IL, Bloom FE. Inflammatory cytokines: putative regulators of neuronal and neuro-endocrine function. Brain Research. Brain Research Reviews. 26: 320-6. PMID 9651548 DOI: 10.1016/S0165-0173(97)00041-6  0.668
1998 Roberts AJ, McArthur RA, Hull EE, Post C, Koob GF. Effects of amperozide, 8-OH-DPAT, and FG 5974 on operant responding for ethanol. Psychopharmacology. 137: 25-32. PMID 9631953 DOI: 10.1007/S002130050589  0.349
1998 Epping-Jordan MP, Watkins SS, Koob GF, Markou A. Dramatic decreases in brain reward function during nicotine withdrawal. Nature. 393: 76-9. PMID 9590692 DOI: 10.1038/30001  0.633
1998 Solbrig MV, Koob GF, Lipkin WI. Cocaine sensitivity in Borna disease virus-infected rats. Pharmacology, Biochemistry, and Behavior. 59: 1047-52. PMID 9586866 DOI: 10.1016/S0091-3057(97)00507-8  0.366
1998 Koob GF, Rocio M, Carrera A, Gold LH, Heyser CJ, Maldonado-Irizarry C, Markou A, Parsons LH, Roberts AJ, Schulteis G, Stinus L, Walker JR, Weissenborn R, Weiss F. Substance dependence as a compulsive behavior. Journal of Psychopharmacology (Oxford, England). 12: 39-48. PMID 9584967 DOI: 10.1177/026988119801200106  0.804
1998 Heinrichs SC, Menzaghi F, Koob GF. Neuropeptide Y-induced feeding and its control. Vitamins and Hormones. 54: 51-66. PMID 9529973 DOI: 10.1016/S0083-6729(08)60921-8  0.642
1998 Epping-Jordan MP, Markou A, Koob GF. The dopamine D-1 receptor antagonist SCH 23390 injected into the dorsolateral bed nucleus of the stria terminalis decreased cocaine reinforcement in the rat. Brain Research. 784: 105-15. PMID 9518570 DOI: 10.1016/S0006-8993(97)01190-6  0.663
1998 Markou A, Kosten TR, Koob GF. Neurobiological similarities in depression and drug dependence: a self-medication hypothesis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 18: 135-74. PMID 9471114 DOI: 10.1016/S0893-133X(97)00113-9  0.617
1998 Heyser CJ, Schulteis G, Durbin P, Koob GF. Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 18: 125-33. PMID 9430136 DOI: 10.1016/S0893-133X(97)00130-9  0.419
1998 Koob GF. Drug abuse and alcoholism. Overview Advances in Pharmacology (San Diego, Calif.). 42: 969-977. PMID 9328060 DOI: 10.1016/S1054-3589(08)60909-6  0.406
1998 Parsons LH, Weiss F, Koob GF. Serotonin1BReceptor Stimulation Enhances Cocaine Reinforcement The Journal of Neuroscience. 18: 10078-10089. DOI: 10.1523/Jneurosci.18-23-10078.1998  0.801
1998 Roberts AJ, Smith AD, Weiss F, Rivier C, Koob GF. Estrous Cycle Effects on Operant Responding for Ethanol in Female Rats Alcoholism: Clinical and Experimental Research. 22: 1564-1569. DOI: 10.1111/J.1530-0277.1998.Tb03950.X  0.618
1998 Koob GF, Roberts AJ, Schulteis G, Parsons LH, Heyser CJ, Hyytia P, Merlo-Pich E, Weiss F. Neurocircuitry Targets in Ethanol Reward and Dependence Alcoholism: Clinical and Experimental Research. 22: 3-9. DOI: 10.1111/J.1530-0277.1998.Tb03611.X  0.798
1998 Baldo BA, Koob GF. EFFECTS OF ADENOSINE A2 RECEPTOR-SELECTIVE DRUGS ON BRAIN STIMULATION REWARD THRESHOLDS IN THE RAT Behavioural Pharmacology. 9: S12. DOI: 10.1097/00008877-199808000-00006  0.497
1997 Walker JR, Koob GF. Orphan anxiety Proceedings of the National Academy of Sciences of the United States of America. 94: 14217-14219. PMID 9405592 DOI: 10.1073/pnas.94.26.14217  0.303
1997 Koob GF, Le Moal M. Drug abuse: hedonic homeostatic dysregulation. Science (New York, N.Y.). 278: 52-8. PMID 9311926 DOI: 10.1126/science.278.5335.52  0.571
1997 Ahmed SH, Koob GF. Cocaine- but not food-seeking behavior is reinstated by stress after extinction. Psychopharmacology. 132: 289-95. PMID 9292629 DOI: 10.1007/s002130050347  0.678
1997 Brot MD, Rall GF, Oldstone MB, Koob GF, Gold LH. Deficits in discriminated learning remain despite clearance of long-term persistent viral infection in mice. Journal of Neurovirology. 3: 265-73. PMID 9291234 DOI: 10.3109/13550289709029467  0.483
1997 Koob GF, Nestler EJ. The neurobiology of drug addiction Journal of Neuropsychiatry and Clinical Neurosciences. 9: 482-497. PMID 9276849 DOI: 10.1176/JNP.9.3.482  0.393
1997 Britton KT, Southerland S, Uden EV, Kirby D, Rivier J, Koob G. Anxiolytic activity of NPY receptor agonists in the conflict test Psychopharmacology. 132: 6-13. PMID 9272753 DOI: 10.1007/S002130050313  0.335
1997 Heyser CJ, McDonald JS, Beauchamp V, Koob GF, Gold LH. The effects of cocaine on operant responding for food in several strains of mice. Psychopharmacology. 132: 202-8. PMID 9266618 DOI: 10.1007/S002130050337  0.551
1997 Caine SB, Koob GF, Parsons LH, Everitt BJ, Schwartz JC, Sokoloff P. D3 receptor test in vitro predicts decreased cocaine self-administration in rats. Neuroreport. 8: 2373-7. PMID 9243643 DOI: 10.1097/00001756-199707070-00054  0.76
1997 Koob GF, Caine SB, Parsons L, Markou A, Weiss F. Opponent process model and psychostimulant addiction. Pharmacology, Biochemistry, and Behavior. 57: 513-21. PMID 9218276 DOI: 10.1016/S0091-3057(96)00438-8  0.816
1997 Deroche V, Caine SB, Heyser CJ, Polis I, Koob GF, Gold LH. Differences in the liability to self-administer intravenous cocaine between C57BL/6 x SJL and BALB/cByJ mice. Pharmacology, Biochemistry, and Behavior. 57: 429-40. PMID 9218267 DOI: 10.1016/S0091-3057(96)00439-X  0.572
1997 Rodríguez de Fonseca F, Carrera MR, Navarro M, Koob GF, Weiss F. Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal. Science (New York, N.Y.). 276: 2050-4. PMID 9197270 DOI: 10.1126/Science.276.5321.2050  0.686
1997 Brot MD, Akwa Y, Purdy RH, Koob GF, Britton KT. The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors. European Journal of Pharmacology. 325: 1-7. PMID 9151931 DOI: 10.1016/S0014-2999(97)00096-4  0.317
1997 Schulteis G, Heyser CJ, Koob GF. Opiate withdrawal signs precipitated by naloxone following a single exposure to morphine: potentiation with a second morphine exposure. Psychopharmacology. 129: 56-65. PMID 9122364 DOI: 10.1007/s002130050162  0.329
1997 Raber J, Koob GF, Bloom FE. Interferon-alpha and transforming growth factor-beta 1 regulate corticotropin-releasing factor release from the amygdala: comparison with the hypothalamic response. Neurochemistry International. 30: 455-63. PMID 9106261 DOI: 10.1016/S0197-0186(96)00082-4  0.667
1997 Pulvirenti L, Balducci C, Koob GF. Dextromethorphan reduces intravenous cocaine self-administration in the rat. European Journal of Pharmacology. 321: 279-83. PMID 9085038 DOI: 10.1016/S0014-2999(96)00970-3  0.4
1997 Bono G, Balducci C, Richelmi P, Koob GF, Pulvirenti L. Dopamine partial receptor agonists reduce ethanol intake in the rat. European Journal of Pharmacology. 296: 233-8. PMID 8904074 DOI: 10.1016/0014-2999(95)00592-7  0.425
1997 Heyser CJ, Schulteis G, Koob GF. Increased Ethanol Self-Administration after a Period of Imposed Ethanol Deprivation in Rats Trained in a Limited Access Paradigm Alcoholism: Clinical and Experimental Research. 21: 784-791. DOI: 10.1111/J.1530-0277.1997.TB03840.X  0.381
1997 Koob GF. Circuits, Drugs, and Drug Addiction Advances in Pharmacology. 42: 978-982. DOI: 10.1016/S1054-3589(08)60910-2  0.367
1997 Schulteis G, Gold LH, Koob GF. Preclinical behavioral models for addressing unmet needs in opiate addiction Seminars in the Neurosciences. 9: 94-109. DOI: 10.1006/smns.1997.0110  0.57
1996 Pulvirenti L, Balducci C, Koob GF. Inhibition of nitric oxide synthesis reduces intravenous cocaine self-administration in the rat Neuropharmacology. 35: 1811-1814. PMID 9076761 DOI: 10.1016/S0028-3908(96)00152-9  0.378
1996 Parsons LH, Weiss F, Koob GF. Serotonin1b receptor stimulation enhances dopamine-mediated reinforcement. Psychopharmacology. 128: 150-60. PMID 8956376 DOI: 10.1007/S002130050120  0.801
1996 Schulteis G, Koob GF. Reinforcement processes in opiate addiction: a homeostatic model. Neurochemical Research. 21: 1437-54. PMID 8947934 DOI: 10.1007/BF02532385  0.363
1996 Prospéro-García O, Gold LH, Fox HS, Polis I, Koob GF, Bloom FE, Henriksen SJ. Microglia-passaged simian immunodeficiency virus induces neurophysiological abnormalities in monkeys. Proceedings of the National Academy of Sciences of the United States of America. 93: 14158-63. PMID 8943077 DOI: 10.1073/Pnas.93.24.14158  0.739
1996 Roberts AJ, Cole M, Koob GF. Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats Alcoholism: Clinical and Experimental Research. 20: 1289-1298. PMID 8904984 DOI: 10.1111/J.1530-0277.1996.Tb01125.X  0.446
1996 Weissenborn R, Deroche V, Koob GF, Weiss F. Effects of dopamine agonists and antagonists on cocaine-induced operant responding for a cocaine-associated stimulus. Psychopharmacology. 126: 311-22. PMID 8878347 DOI: 10.1007/Bf02247382  0.813
1996 Heinrichs SC, Stenzel-Poore MP, Gold LH, Battenberg E, Bloom FE, Koob GF, Vale WW, Pich EM. Learning impairment in transgenic mice with central overexpression of corticotropin-releasing factor. Neuroscience. 74: 303-11. PMID 8865183 DOI: 10.1016/0306-4522(96)00140-6  0.758
1996 Vankova ME, Weinger MB, Chen DY, Bronson JB, Motis V, Koob GF. Role of central mu, delta-1, and kappa-1 opioid receptors in opioid-induced muscle rigidity in the rat. Anesthesiology. 85: 574-83. PMID 8853088 DOI: 10.1097/00000542-199609000-00017  0.309
1996 Hyytiä P, Schulteis G, Koob GF. Intravenous heroin and ethanol self-administration by alcohol-preferring AA and alcohol-avoiding ANA rats. Psychopharmacology. 125: 248-54. PMID 8815960 DOI: 10.1007/BF02247335  0.437
1996 Macey DJ, Schulteis G, Heinrichs SC, Koob GF. Time-dependent quantifiable withdrawal from ethanol in the rat: effect of method of dependence induction. Alcohol (Fayetteville, N.Y.). 13: 163-70. PMID 8814651 DOI: 10.1016/0741-8329(95)02030-6  0.652
1996 Solbrig MV, Koob GF, Joyce JN, Lipkin WI. A neural substrate of hyperactivity in Borna disease: Changes in brain dopamine receptors Virology. 222: 332-338. PMID 8806517 DOI: 10.1006/Viro.1996.0430  0.312
1996 Solbrig MV, Koob GF, Lipkin WI. Naloxone-induced seizures in rats infected with Borna disease virus. Neurology. 46: 1170-1. PMID 8780117 DOI: 10.1212/WNL.46.4.1170  0.309
1996 Parsons LH, Caine SB, Sokoloff P, Schwartz JC, Koob GF, Weiss F. Neurochemical evidence that postsynaptic nucleus accumbens D3 receptor stimulation enhances cocaine reinforcement. Journal of Neurochemistry. 67: 1078-89. PMID 8752115 DOI: 10.1046/J.1471-4159.1996.67031078.X  0.805
1996 Matthews K, Baldo BA, Markou A, Lown O, Overstreet DH, Koob GF. Rewarding electrical brain stimulation: similar thresholds for Flinders Sensitive Line Hypercholinergic and Flinders Resistant Line Hypocholinergic rats. Physiology & Behavior. 59: 1155-62. PMID 8737906 DOI: 10.1016/0031-9384(95)02212-0  0.725
1996 Korte SM, Korte-Bouws GA, Koob GF, De Kloet ER, Bohus B. Mineralocorticoid and glucocorticoid receptor antagonists in animal models of anxiety. Pharmacology, Biochemistry, and Behavior. 54: 261-7. PMID 8728567 DOI: 10.1016/0091-3057(95)02172-8  0.745
1996 Spina M, Merlo-Pich E, Chan RK, Basso AM, Rivier J, Vale W, Koob GF. Appetite-suppressing effects of urocortin, a CRF-related neuropeptide. Science (New York, N.Y.). 273: 1561-4. PMID 8703220 DOI: 10.1126/science.273.5281.1561  0.404
1996 de la Torre JC, Mallory M, Brot M, Gold L, Koob G, Oldstone MB, Masliah E. Viral persistence in neurons alters synaptic plasticity and cognitive functions without destruction of brain cells. Virology. 220: 508-15. PMID 8661403 DOI: 10.1006/Viro.1996.0340  0.481
1996 Schulteis G, Hyytiä P, Heinrichs SC, Koob GF. Effects of chronic ethanol exposure on oral self-administration of ethanol or saccharin by Wistar rats. Alcoholism, Clinical and Experimental Research. 20: 164-71. PMID 8651448 DOI: 10.1111/j.1530-0277.1996.tb01060.x  0.665
1996 Koob GF. Drug addiction: The Yin and Yang of hedonic homeostasis Neuron. 16: 893-896. PMID 8630244 DOI: 10.1016/S0896-6273(00)80109-9  0.354
1996 Weiss F, Parsons LH, Schulteis G, Hyytiä P, Lorang MT, Bloom FE, Koob GF. Ethanol Self-Administration Restores Withdrawal-Associated Deficiencies in Accumbal Dopamine and 5-Hydroxytryptamine Release in Dependent Rats The Journal of Neuroscience. 16: 3474-3485. DOI: 10.1523/Jneurosci.16-10-03474.1996  0.807
1996 HEYSER CJ, BEAUCHAMP V, MCDONALD J, KOOB GF, GOLD LH. THE EXTENDED AMYGDALA AND THE CAUDOMEDIAL SHELL OF THE ACCUMBENS; AN ???EMOTIONAL-MOTOR??? INTERFACE Behavioural Pharmacology. 7: 51. DOI: 10.1097/00008877-199605001-00115  0.48
1996 GOLD LH, HEYSER CJ, ROBERTS AJ, CAINE SB, XU M, FIENBERG A, POLIS I, INGRASSIA P, GREENGARD P, TONEGAWA S, KOOB GF. COCAINE-INDUCED EFFECTS ON MALE RAT SEXUAL BEHAVIOUR AND STRETCHING-YAWNING Behavioural Pharmacology. 7: 45. DOI: 10.1097/00008877-199605001-00102  0.554
1996 Menzaghi F, Heinrichs SC, Vargas-Cortes M, Goldstein G, Koob GF. IRI-514, a synthetic peptide analogue of thymopentin, reduces the behavioral response to social stress in rats Physiology & Behavior. 60: 397-401. DOI: 10.1016/S0031-9384(96)80010-2  0.628
1996 Heinrichs S, Rassnick S, Schulteis G, Menzaghi F, Merlo Pich E, Richter R, Weiss F, Koob G. Involvement of corticotropin-releasing factor in addiction European Neuropsychopharmacology. 6: S4-5. DOI: 10.1016/0924-977X(96)83169-5  0.713
1995 Heinrichs SC, Menzaghi F, Merlo Pich E, Britton KT, Koob GF. The role of CRF in behavioral aspects of stress. Annals of the New York Academy of Sciences. 771: 92-104. PMID 8597448 DOI: 10.1111/j.1749-6632.1995.tb44673.x  0.773
1995 Caine SB, Heinrichs SC, Coffin VL, Koob GF. Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat. Brain Research. 692: 47-56. PMID 8548319 DOI: 10.1016/0006-8993(95)00598-K  0.674
1995 Pulvirenti L, Smith D, Koob GF. SDZ 208-911, an amino-ergoline with partial dopamine agonist properties, dose dependently increases cocaine self-administration in the rat. Psychopharmacology. 113: 518-20. PMID 7862868 DOI: 10.1007/BF02245232  0.442
1995 Rodríguez De Fonseca F, Rubio P, Martín-Calderón JL, Caine SB, Koob GF, Navarro M. The dopamine receptor agonist 7-OH-DPAT modulates the acquisition and expression of morphine-induced place preference. European Journal of Pharmacology. 274: 47-55. PMID 7768280 DOI: 10.1016/0014-2999(94)00708-F  0.361
1995 Weinger MB, Chen DY, Lin T, Lau C, Koob GF, Smith NT. A role for CNS alpha-2 adrenergic receptors in opiate-induced muscle rigidity in the rat. Brain Research. 669: 10-8. PMID 7712151 DOI: 10.1016/0006-8993(94)01216-5  0.341
1995 Richter RM, Pich EM, Koob GF, Weiss F. Sensitization of cocaine-stimulated increase in extracellular levels of corticotropin-releasing factor from the rat amygdala after repeated administration as determined by intracranial microdialysis. Neuroscience Letters. 187: 169-72. PMID 7624019 DOI: 10.1016/0304-3940(95)11365-4  0.648
1995 Schulteis G, Markou A, Cole M, Koob GF. Decreased brain reward produced by ethanol withdrawal. Proceedings of the National Academy of Sciences of the United States of America. 92: 5880-4. PMID 7597046 DOI: 10.1073/Pnas.92.13.5880  0.663
1995 Weissenborn R, Yackey M, Koob GF, Weiss F. Measures of cocaine-seeking behavior using a multiple schedule of food and drug self-administration in rats. Drug and Alcohol Dependence. 38: 237-46. PMID 7555624 DOI: 10.1016/0376-8716(95)01107-A  0.814
1995 Carrera MR, Ashley JA, Parsons LH, Wirsching P, Koob GF, Janda KD. Suppression of psychoactive effects of cocaine by active immunization. Nature. 378: 727-30. PMID 7501020 DOI: 10.1038/378727A0  0.76
1995 Hyytiä P, Koob GF. GABAA receptor antagonism in the extended amygdala decreases ethanol self-administration in rats European Journal of Pharmacology. 283: 151-159. PMID 7498304 DOI: 10.1016/0014-2999(95)00314-B  0.404
1995 Pich E, Lorang M, Yeganeh M, Fonseca FRd, Raber J, Koob G, Weiss F. Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis The Journal of Neuroscience. 15: 5439-5447. DOI: 10.1523/Jneurosci.15-08-05439.1995  0.626
1994 Solbrig MV, Koob GF, Fallon JH, Lipkin WI. Tardive dyskinetic syndrome in rats infected with Borna disease virus. Neurobiology of Disease. 1: 111-9. PMID 9173990 DOI: 10.1006/Nbdi.1994.0014  0.315
1994 Koob GF, Caine B, Markou A, Pulvirenti L, Weiss F. Role for the mesocortical dopamine system in the motivating effects of cocaine. Nida Research Monograph. 145: 1-18. PMID 8742805  0.814
1994 Robledo P, Maldonado R, Koob GF. Neurotensin injected into the nucleus accumbens blocks the psychostimulant effects of cocaine but does not attenuate cocaine self-administration in the rat. Brain Research. 622: 105-12. PMID 8242350 DOI: 10.1016/0006-8993(93)90808-Z  0.421
1994 Cole BJ, Koob GF. Corticotropin-releasing factor and schedule-induced polydipsia. Pharmacology, Biochemistry, and Behavior. 47: 393-8. PMID 8208756 DOI: 10.1016/0091-3057(94)90134-1  0.371
1994 Stenzel-Poore MP, Heinrichs SC, Rivest S, Koob GF, Vale WW. Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 2579-84. PMID 8182429 DOI: 10.1523/Jneurosci.14-05-02579.1994  0.651
1994 Caine SB, Koob GF. Effects of mesolimbic dopamine depletion on responding maintained by cocaine and food Journal of the Experimental Analysis of Behavior. 61: 213-221. PMID 8169570 DOI: 10.1901/JEAB.1994.61-213  0.402
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