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Year Citation  Score
2023 Sun C, Ye Y, Tan Z, Liu Y, Li Y, Hu W, Liang K, Egranov SD, Huang LA, Zhang Z, Zhang Y, Yao J, Nguyen TK, Zhao Z, Wu A, ... ... Chiao PJ, et al. Tumor-associated nonmyelinating Schwann cell-expressed promotes pancreatic cancer kynurenine pathway and tumor immune exclusion. Science Advances. 9: eadd6995. PMID 36724291 DOI: 10.1126/sciadv.add6995  0.332
2021 Chen Y, Capello M, Rios Perez MV, Vykoukal JV, Roife D, Kang Y, Prakash LR, Katayama H, Irajizad E, Fleury A, Ferri-Borgogno S, Baluya DL, Dennison JB, Do KA, Fiehn O, ... ... Chiao PJ, et al. CES2 sustains HNF4α expression to promote pancreatic adenocarcinoma progression through an epoxide hydrolase-dependent regulatory loop. Molecular Metabolism. 56: 101426. PMID 34971802 DOI: 10.1016/j.molmet.2021.101426  0.304
2020 Lu Y, Wu M, Fu J, Sun Y, Furukawa K, Ling J, Qin X, Chiao PJ. The overexpression of long intergenic ncRNA00162 induced by RelA/p65 promotes growth of pancreatic ductal adenocarcinoma. Cell Proliferation. e12805. PMID 32364285 DOI: 10.1111/Cpr.12805  0.359
2020 Liu Y, Gu Y, Ng S, Deng Z, Lyon CJ, Koay EJ, Ning B, Katz MH, Chiao PJ, Fan J, Han H, Von Hoff D, Hu TY. Circulating levels of hydroxylated bradykinin function as an indicator of tissue HIF-1α expression Science Bulletin. 65: 1570-1579. DOI: 10.1016/J.Scib.2020.04.023  0.358
2019 Hu K, Li K, Lv J, Feng J, Chen J, Wu H, Cheng F, Jiang W, Wang J, Pei H, Chiao PJ, Cai Z, Chen Y, Liu M, Pang X. Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma. The Journal of Clinical Investigation. PMID 31874110 DOI: 10.1172/Jci124049  0.411
2019 Ling J, Chiao PJ. Two Birds with One Stone: Therapeutic Targeting of IL1α Signaling Pathways in Pancreatic Ductal Adenocarcinoma and the Cancer-Associated Fibroblasts. Cancer Discovery. 9: 173-175. PMID 30737215 DOI: 10.1158/2159-8290.Cd-18-1460  0.459
2019 Deng Z, Zhao Z, Ning B, Basilio J, Mann K, Fu J, Gu Y, Ye Y, Wu X, Fan J, Chiao P, Hu T. Nanotrap-enabled quantification of KRAS-induced peptide hydroxylation in blood for cancer early detection Nano Research. 12: 1445-1452. DOI: 10.1007/S12274-019-2405-9  0.336
2018 Ju HQ, Lu YX, Chen DL, Zuo ZX, Liu ZX, Wu QN, Mo HY, Wang ZX, Wang DS, Pu HY, Zeng ZL, Li B, Xie D, Huang P, Hung MC, ... Chiao PJ, et al. Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications. Journal of the National Cancer Institute. PMID 30534944 DOI: 10.1093/Jnci/Djy160  0.358
2018 Zhou L, Husted H, Moore T, Lu M, Deng D, Liu Y, Ramachandran V, Arumugam T, Niehrs C, Wang H, Chiao P, Ling J, Curran MA, Maitra A, Hung MC, et al. Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma. Science Translational Medicine. 10. PMID 30355799 DOI: 10.1126/Scitranslmed.Aat3487  0.414
2018 Sun Y, Jiang W, Lu W, Song M, Liu K, Chen P, Chang A, Ling J, Chiao PJ, Hu Y, Huang P. Identification of cisplatin sensitizers through high-throughput combinatorial screening. International Journal of Oncology. PMID 29956742 DOI: 10.3892/Ijo.2018.4447  0.316
2018 Zhang B, Fu D, Xu Q, Cong X, Wu C, Zhong X, Ma Y, Lv Z, Chen F, Han L, Qian M, Chin YE, Lam EW, Chiao P, Sun Y. The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1. Nature Communications. 9: 1723. PMID 29712904 DOI: 10.1038/S41467-018-04010-4  0.418
2018 Zhang Y, Zoltan M, Riquelme E, Xu H, Sahin I, Castro-Pando S, Montiel MF, Chang K, Jiang Z, Ling J, Gupta S, Horne W, Pruski M, Wang H, Sun SC, ... ... Chiao P, et al. Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells. Gastroenterology. PMID 29604293 DOI: 10.1053/J.Gastro.2018.03.041  0.387
2018 Yang W, Xia Y, Cao Y, Zheng Y, Bu W, Zhang L, You MJ, Koh MY, Cote G, Aldape K, Li Y, Verma IM, Chiao PJ, Lu Z. EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis. Molecular Cell. 69: 347. PMID 29351852 DOI: 10.1016/J.Molcel.2017.12.034  0.453
2017 Chen DL, Lu YX, Zhang JX, Wei XL, Wang F, Zeng ZL, Pan ZZ, Yuan YF, Wang FH, Pelicano H, Chiao PJ, Huang P, Xie D, Li YH, Ju HQ, et al. Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB2 expression. Theranostics. 7: 4836-4849. PMID 29187907 DOI: 10.7150/Thno.20942  0.398
2017 Santoro R, Carbone C, Piro G, Chiao PJ, Melisi D. TAK-ing aim at chemoresistance: The emerging role of MAP3K7 as a target for cancer therapy. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 33: 36-42. PMID 29145973 DOI: 10.1016/J.Drup.2017.10.004  0.449
2017 Zhou H, Qin Y, Ji S, Ling J, Fu J, Zhuang Z, Fan X, Song L, Yu X, Chiao PJ. SOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer. Oncogene. PMID 29059173 DOI: 10.1038/Onc.2017.393  0.559
2017 Zhuang Z, Li H, Lee H, Aguilar M, Gocho T, Ju H, Iida T, Ling J, Fu J, Wu M, Sun Y, Lu Y, Chiao PJ. NEMO Peptide Inhibits the Growth of Pancreatic Ductal Adenocarcinoma by Blocking NF-κB Activation. Cancer Letters. PMID 28951128 DOI: 10.1016/J.Canlet.2017.09.018  0.534
2017 Chiao PJ, Ling J, Fu J, Lu Y, Sun YC. Inhibition of Pancreatic Cancer by RhIL1RA-Response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 23: 3224. PMID 28620001 DOI: 10.1158/1078-0432.Ccr-17-0083  0.424
2017 Ju HQ, Ying H, Tian T, Ling J, Fu J, Lu Y, Wu M, Yang L, Achreja A, Chen G, Zhuang Z, Wang H, Nagrath D, Yao J, Hung MC, ... ... Chiao PJ, et al. Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma. Nature Communications. 8: 14437. PMID 28232723 DOI: 10.1038/Ncomms14437  0.415
2016 Xu Q, Chiao P, Sun Y. Amphiregulin in Cancer: New Insights for Translational Medicine. Trends in Cancer. 2: 111-113. PMID 28741529 DOI: 10.1016/J.Trecan.2016.02.002  0.392
2016 Gao S, Sun Y, Zhang X, Hu L, Liu Y, Chua YX, Phillips LM, Ren H, Fleming JB, Wang H, Chiao PJ, Hao J, Zhang W. IGFBP2 activates the NF-κB pathway to drive epithelial-mesenchymal transition and invasive character in pancreatic ductal adenocarcinoma. Cancer Research. PMID 27659045 DOI: 10.1158/0008-5472.Can-16-0438  0.509
2016 Ju HQ, Zhuang ZN, Li H, Tian T, Lu YX, Fan XQ, Zhou HJ, Mo HY, Sheng H, Chiao PJ, Xu RH. Regulation of the Nampt-mediated NAD salvage pathway and its therapeutic implications in pancreatic cancer. Cancer Letters. PMID 27233476 DOI: 10.1016/J.Canlet.2016.05.024  0.489
2016 Fleming JB, Kang Y, Roife D, Lee Y, Lv H, Suzuki R, Ling J, Rios Perez MV, Li X, Dai B, Pratt M, Truty MJ, Chatterjee D, Wang H, Thomas RM, ... ... Chiao PJ, et al. Transforming Growth Factor-β Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27126993 DOI: 10.1158/1078-0432.Ccr-15-2780  0.439
2016 Ji S, Qin Y, Liang C, Huang R, Shi S, Liu J, Jin K, Liang D, Xu W, Zhang B, Liu L, Liu C, Xu J, Ni Q, Chiao PJ, et al. FBW7 (F-box and WD repeat domain-containing 7) negatively regulates glucose metabolism by targeting the c-Myc/TXNIP (thioredoxin binding protein) axis in pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26983463 DOI: 10.1158/1078-0432.Ccr-15-2380  0.425
2016 Sun Y, Zhang B, Chen F, Chiao P. Abstract LB-234: A persistently activated signaling network regulates the DNA damage secretory program to promote cancer resistance driven by the therapeutically damaged tumor microenvironment Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-234  0.455
2016 Ling J, Fu J, Wu M, Cao Y, Chiao P. Abstract 665: Blocking IL-1-NF-kB axis inhibits Kras-induced pancreatic ductal adenocarcinoma Cancer Research. 76: 665-665. DOI: 10.1158/1538-7445.Am2016-665  0.448
2015 Sun L, Chua CY, Tian W, Zhang Z, Chiao PJ, Zhang W. MicroRNA Signaling Pathway Network in Pancreatic Ductal Adenocarcinoma. Journal of Genetics and Genomics = Yi Chuan Xue Bao. 42: 563-77. PMID 26554910 DOI: 10.1016/J.Jgg.2015.07.003  0.372
2015 Zhuang ZN, Ju HQ, Aguilar M, Gocho T, Li H, Iida T, Lee H, Fan X, Zhou H, Ling J, Li Z, Fu J, Wu M, Li M, Melisi D, ... ... Chiao PJ, et al. IL-1 Receptor Antagonist Inhibits Pancreatic Cancer Growth by Abrogating NF-κB Activation. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26500238 DOI: 10.1158/1078-0432.Ccr-14-3382  0.47
2015 Ju HQ, Li H, Tian T, Lu YX, Long B, Le-Zong C, Sheng H, Hai-Yu M, Jun-Bo Z, Deng W, Chiao PJ, Xu RH. Melatonin overcomes gemcitabine resistance in pancreatic ductal adenocarcinoma by abrogating NF-κB activation. Journal of Pineal Research. PMID 26445000 DOI: 10.1111/Jpi.12285  0.513
2015 Wang P, Zhu CF, Ma MZ, Chen G, Song M, Zeng ZL, Lu WH, Yang J, Wen S, Chiao PJ, Hu Y, Huang P. Micro-RNA-155 is induced by K-Ras oncogenic signal and promotes ROS stress in pancreatic cancer. Oncotarget. PMID 26020803 DOI: 10.18632/Oncotarget.4125  0.346
2015 Ji S, Qin Y, Shi S, Liu X, Hu H, Zhou H, Gao J, Zhang B, Xu W, Liu J, Liang D, Liu L, Liu C, Long J, Zhou H, ... Chiao PJ, et al. ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer. Cell Research. 25: 561-73. PMID 25753158 DOI: 10.1038/Cr.2015.30  0.448
2015 Ju HQ, Gocho T, Aguilar M, Wu M, Zhuang ZN, Fu J, Yanaga K, Huang P, Chiao PJ. Mechanisms of Overcoming Intrinsic Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma through the Redox Modulation. Molecular Cancer Therapeutics. 14: 788-98. PMID 25527634 DOI: 10.1158/1535-7163.Mct-14-0420  0.424
2015 Carbone C, Piro G, Fassan M, Tamburrino A, Mina MM, Zanotto M, Chiao PJ, Bassi C, Scarpa A, Tortora G, Melisi D. An angiopoietin-like protein 2 autocrine signaling promotes EMT during pancreatic ductal carcinogenesis. Oncotarget. 6: 13822-34. PMID 25360865 DOI: 10.18632/Oncotarget.2635  0.444
2015 Ju H, Gocho T, Aguilar M, Zhuang Z, Fu J, Wu M, Yanaga K, Huang P, Chiao P. Abstract A105: Mechanisms of overcoming intrinsic resistance to gemcitabine in pancreatic ductal adenocarcinoma through redox modulation Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-A105  0.441
2014 Kang Y, Ling J, Suzuki R, Roife D, Chopin-Laly X, Truty MJ, Chatterjee D, Wang H, Thomas RM, Katz MH, Chiao PJ, Fleming JB. SMAD4 regulates cell motility through transcription of N-cadherin in human pancreatic ductal epithelium. Plos One. 9: e107948. PMID 25264609 DOI: 10.1371/Journal.Pone.0107948  0.371
2014 Chang Z, Ju H, Ling J, Zhuang Z, Li Z, Wang H, Fleming JB, Freeman JW, Yu D, Huang P, Chiao PJ. Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis. Plos One. 9: e101452. PMID 25029561 DOI: 10.1371/Journal.Pone.0101452  0.414
2014 Chiao PJ, Zhuang Z, Xia Q, Schuber PT, Sun D, Peng Z, Maxwell DS, Bornmann WG. Abstract 1727: Development of novel TAK1 inhibitors for pancreatic cancer Cancer Research. 74: 1727-1727. DOI: 10.1158/1538-7445.Am2014-1727  0.435
2013 Bera A, Zhao S, Cao L, Chiao PJ, Freeman JW. Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-κB Axis that induces expression of MMP9 and uPA in human pancreas progenitor cells. Plos One. 8: e82282. PMID 24340014 DOI: 10.1371/Journal.Pone.0082282  0.403
2013 Zhang Y, Yang J, Cui X, Chen Y, Zhu VF, Hagan JP, Wang H, Yu X, Hodges SE, Fang J, Chiao PJ, Logsdon CD, Fisher WE, Brunicardi FC, Chen C, et al. A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth. Embo Molecular Medicine. 5: 1322-34. PMID 23857777 DOI: 10.1002/Emmm.201302507  0.385
2013 Chang Z, Li Z, Wang X, Kang Y, Yuan Y, Niu J, Wang H, Chatterjee D, Fleming JB, Li M, Abbruzzese JL, Chiao PJ. Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 549-59. PMID 23340292 DOI: 10.1158/1078-0432.Ccr-12-0032  0.693
2013 Zhang Y, Chen L, Yang J, Fleming JB, Chiao PJ, Logsdon CD, Li M. Study human pancreatic cancer in mice: how close are they? Biochimica Et Biophysica Acta. 1835: 110-8. PMID 23147198 DOI: 10.1016/J.Bbcan.2012.11.001  0.376
2013 Ling J, Kang Y, Chiao P. Abstract 2741: NF-κB activation by IL-1α and p62 feedforward loops is required for Kras-induced pancreatic ductal adenocarcinoma. Cancer Research. 73: 2741-2741. DOI: 10.1158/1538-7445.Am2013-2741  0.455
2013 Chang Z, Li Z, Wang XY, Zhao RY, Ling JH, Yuan YH, Wang H, Chatterjee D, Fleming JB, Freeman JW, Yu D, Chiao PJ. Cooperativity of oncogenic K-ras and silenced p16 in human pancreatic tumorigenesis Pancreatology. 13. DOI: 10.1016/J.Pan.2012.12.120  0.318
2012 Yang W, Xia Y, Cao Y, Zheng Y, Bu W, Zhang L, You MJ, Koh MY, Cote G, Aldape K, Li Y, Verma IM, Chiao PJ, Lu Z. EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis. Molecular Cell. 48: 771-84. PMID 23123196 DOI: 10.1016/J.Molcel.2012.09.028  0.459
2012 Ling J, Kang Y, Zhao R, Xia Q, Lee DF, Chang Z, Li J, Peng B, Fleming JB, Wang H, Liu J, Lemischka IR, Hung MC, Chiao PJ. KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell. 21: 105-20. PMID 22264792 DOI: 10.1016/J.Ccr.2011.12.006  0.404
2012 Hu Y, Lu W, Chen G, Wang P, Chen Z, Zhou Y, Ogasawara M, Trachootham D, Feng L, Pelicano H, Chiao PJ, Keating MJ, Garcia-Manero G, Huang P. K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis. Cell Research. 22: 399-412. PMID 21876558 DOI: 10.1038/Cr.2011.145  0.33
2012 Li Z, Chang Z, Chiao PJ. Abstract 2186: Function and regulation of Polo-like Kinase 3 in human pancreatic cancer Cancer Research. 72: 2186-2186. DOI: 10.1158/1538-7445.Am2012-2186  0.483
2011 Chiao PJ, Ling J. Kras, Pten, NF-κB, and inflammation: dangerous liaisons. Cancer Discovery. 1: 103-5. PMID 22586351 DOI: 10.1158/2159-8290.Cd-11-0115  0.369
2011 Melisi D, Xia Q, Paradiso G, Ling J, Moccia T, Carbone C, Budillon A, Abbruzzese JL, Chiao PJ. Modulation of pancreatic cancer chemoresistance by inhibition of TAK1. Journal of the National Cancer Institute. 103: 1190-204. PMID 21743023 DOI: 10.1093/Jnci/Djr243  0.432
2011 Carbone C, Moccia T, Zhu C, Paradiso G, Budillon A, Chiao PJ, Abbruzzese JL, Melisi D. Anti-VEGF treatment-resistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 5822-32. PMID 21737511 DOI: 10.1158/1078-0432.Ccr-11-1185  0.397
2011 Shim DJ, Yang L, Reed JG, Noebels JL, Chiao PJ, Zheng H. Disruption of the NF-κB/IκBα Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons. Molecular Neurodegeneration. 6: 42. PMID 21663635 DOI: 10.1186/1750-1326-6-42  0.309
2011 Yang G, Xiao X, Rosen DG, Cheng X, Wu X, Chang B, Liu G, Xue F, Mercado-Uribe I, Chiao P, Du X, Liu J. The biphasic role of NF-kappaB in progression and chemoresistance of ovarian cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 2181-94. PMID 21339307 DOI: 10.1158/1078-0432.Ccr-10-3265  0.52
2011 Carbone C, Moccia T, Zhu C, Paradiso G, Simbolo M, Budillon A, Chiao PJ, Abbruzzese JL, Melisi D. Abstract 3287: Pro-inflammatory factors secreted by pancreatic cancers with evasive resistance to anti-VEGF treatment contribute to malignant progression by inducing EMT Cancer Research. 71: 3287-3287. DOI: 10.1158/1538-7445.Am2011-3287  0.44
2010 Peng B, Ling J, Lee AJ, Wang Z, Chang Z, Jin W, Kang Y, Zhang R, Shim D, Wang H, Fleming JB, Zheng H, Sun SC, Chiao PJ. Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter. Proceedings of the National Academy of Sciences of the United States of America. 107: 15193-8. PMID 20696914 DOI: 10.1073/Pnas.1005533107  0.437
2010 Melisi D, Rosa R, Bianco R, Carbone C, Tortora G, Budillon A, Abbruzzese JL, Chiao PJ, Javle M. Abstract 616: R1507, the human monoclonal antibody targeting the insulin-like growth factor receptor (IGF-1R), in combination with cetuximab, can reverse acquired resistance to cetuximab in pancreatic and colon cancer models Cancer Research. 70: 616-616. DOI: 10.1158/1538-7445.Am10-616  0.399
2009 Son K, Fujioka S, Iida T, Furukawa K, Fujita T, Yamada H, Chiao PJ, Yanaga K. Doxycycline induces apoptosis in PANC-1 pancreatic cancer cells. Anticancer Research. 29: 3995-4003. PMID 19846942  0.375
2009 Melisi D, Ossovskaya V, Zhu C, Rosa R, Ling J, Dougherty PM, Sherman BM, Abbruzzese JL, Chiao PJ. Oral poly(ADP-ribose) polymerase-1 inhibitor BSI-401 has antitumor activity and synergizes with oxaliplatin against pancreatic cancer, preventing acute neurotoxicity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 6367-77. PMID 19808866 DOI: 10.1158/1078-0432.Ccr-09-0910  0.418
2009 Li Z, Chang Z, Chiao LJ, Kang Y, Xia Q, Zhu C, Fleming JB, Evans DB, Chiao PJ. TrkBT1 induces liver metastasis of pancreatic cancer cells by sequestering Rho GDP dissociation inhibitor and promoting RhoA activation. Cancer Research. 69: 7851-9. PMID 19773448 DOI: 10.1158/0008-5472.Can-08-4002  0.51
2009 Lu J, Guo H, Treekitkarnmongkol W, Li P, Zhang J, Shi B, Ling C, Zhou X, Chen T, Chiao PJ, Feng X, Seewaldt VL, Muller WJ, Sahin A, Hung MC, et al. 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition. Cancer Cell. 16: 195-207. PMID 19732720 DOI: 10.1016/J.Ccr.2009.08.010  0.385
2009 Uwagawa T, Chiao PJ, Gocho T, Hirohara S, Misawa T, Yanaga K. Combination chemotherapy of nafamostat mesilate with gemcitabine for pancreatic cancer targeting NF-kappaB activation. Anticancer Research. 29: 3173-8. PMID 19661331  0.419
2009 Melisi D, Niu J, Chang Z, Xia Q, Peng B, Ishiyama S, Evans DB, Chiao PJ. Secreted interleukin-1alpha induces a metastatic phenotype in pancreatic cancer by sustaining a constitutive activation of nuclear factor-kappaB. Molecular Cancer Research : McR. 7: 624-33. PMID 19435817 DOI: 10.1158/1541-7786.Mcr-08-0201  0.689
2009 Melisi D, Xia Q, Abbruzzese J, Chiao P. 1002 TGF-β-activated kinase 1 (TAK1) is an in vivo druggable target for reverting pancreatic cancer chemoresistance European Journal of Cancer Supplements. 7: 87. DOI: 10.1016/S1359-6349(09)70295-2  0.339
2008 Melisi D, Ishiyama S, Sclabas GM, Fleming JB, Xia Q, Tortora G, Abbruzzese JL, Chiao PJ. LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Molecular Cancer Therapeutics. 7: 829-40. PMID 18413796 DOI: 10.1158/1535-7163.Mct-07-0337  0.436
2007 Ricci MS, Kim SH, Ogi K, Plastaras JP, Ling J, Wang W, Jin Z, Liu YY, Dicker DT, Chiao PJ, Flaherty KT, Smith CD, El-Deiry WS. Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death. Cancer Cell. 12: 66-80. PMID 17613437 DOI: 10.1016/J.Ccr.2007.05.006  0.44
2007 Xie X, Xia W, Li Z, Kuo HP, Liu Y, Li Z, Ding Q, Zhang S, Spohn B, Yang Y, Wei Y, Lang JY, Evans DB, Chiao PJ, Abbruzzese JL, et al. Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models. Cancer Cell. 12: 52-65. PMID 17613436 DOI: 10.1016/J.Ccr.2007.05.009  0.414
2007 Oida Y, Gopalan B, Miyahara R, Branch CD, Chiao P, Chada S, Ramesh R. Inhibition of nuclear factor-kappaB augments antitumor activity of adenovirus-mediated melanoma differentiation-associated gene-7 against lung cancer cells via mitogen-activated protein kinase kinase kinase 1 activation. Molecular Cancer Therapeutics. 6: 1440-9. PMID 17431123 DOI: 10.1158/1535-7163.Mct-06-0374  0.476
2007 Uwagawa T, Li Z, Chang Z, Xia Q, Peng B, Sclabas GM, Ishiyama S, Hung MC, Evans DB, Abbruzzese JL, Chiao PJ. Mechanisms of synthetic serine protease inhibitor (FUT-175)-mediated cell death. Cancer. 109: 2142-53. PMID 17410536 DOI: 10.1002/Cncr.22658  0.506
2007 Melisi D, Chiao PJ. NF-kappa B as a target for cancer therapy. Expert Opinion On Therapeutic Targets. 11: 133-44. PMID 17227230 DOI: 10.1517/14728222.11.2.133  0.415
2007 Niu J, Chang Z, Peng B, Xia Q, Lu W, Huang P, Tsao MS, Chiao PJ. Keratinocyte growth factor/fibroblast growth factor-7-regulated cell migration and invasion through activation of NF-kappaB transcription factors. The Journal of Biological Chemistry. 282: 6001-11. PMID 17200110 DOI: 10.1074/Jbc.M606878200  0.7
2007 Xia D, Srinivas H, Ahn YH, Sethi G, Sheng X, Yung WK, Xia Q, Chiao PJ, Kim H, Brown PH, Wistuba II, Aggarwal BB, Kurie JM. Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway. The Journal of Biological Chemistry. 282: 3507-19. PMID 17158870 DOI: 10.1074/Jbc.M610141200  0.464
2007 Banerjee S, Zhang Y, Wang Z, Che M, Chiao PJ, Abbruzzese JL, Sarkar FH. In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer. International Journal of Cancer. 120: 906-17. PMID 17131310 DOI: 10.1002/Ijc.22332  0.532
2006 Trachootham D, Zhou Y, Zhang H, Demizu Y, Chen Z, Pelicano H, Chiao PJ, Achanta G, Arlinghaus RB, Liu J, Huang P. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell. 10: 241-52. PMID 16959615 DOI: 10.1016/J.Ccr.2006.08.009  0.4
2006 Kouvaraki MA, Korapati AL, Rassidakis GZ, Tian L, Zhang Q, Chiao P, Ho L, Evans DB, Claret FX. Potential role of Jun activation domain-binding protein 1 as a negative regulator of p27kip1 in pancreatic adenocarcinoma. Cancer Research. 66: 8581-9. PMID 16951171 DOI: 10.1158/0008-5472.Can-06-0975  0.45
2006 Trevino JG, Gray MJ, Nawrocki ST, Summy JM, Lesslie DP, Evans DB, Sawyer TK, Shakespeare WC, Watowich SS, Chiao PJ, McConkey DJ, Gallick GE. Src activation of Stat3 is an independent requirement from NF-kappaB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells. Angiogenesis. 9: 101-10. PMID 16871430 DOI: 10.1007/S10456-006-9038-9  0.45
2006 Choi W, Proctor L, Xia Q, Feng Y, Gerner EW, Chiao PJ, Hamilton SR, Zhang W. Inactivation of IkappaB contributes to transcriptional activation of spermidine/spermine N(1)-acetyltransferase. Molecular Carcinogenesis. 45: 685-93. PMID 16637064 DOI: 10.1002/Mc.20239  0.437
2006 Nawrocki ST, Carew JS, Pino MS, Highshaw RA, Andtbacka RHI, Dunner K, Pal A, Bornmann WG, Chiao PJ, Huang P, Xiong H, Abbruzzese JL, McConkey DJ. Aggresome disruption: A novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells Cancer Research. 66: 3773-3781. PMID 16585204 DOI: 10.1158/0008-5472.Can-05-2961  0.469
2006 Gao Z, He Q, Peng B, Chiao PJ, Ye J. Regulation of nuclear translocation of HDAC3 by IkappaBalpha is required for tumor necrosis factor inhibition of peroxisome proliferator-activated receptor gamma function. The Journal of Biological Chemistry. 281: 4540-7. PMID 16371367 DOI: 10.1074/Jbc.M507784200  0.374
2005 Nawrocki ST, Carew JS, Dunner K, Boise LH, Chiao PJ, Huang P, Abbruzzese JL, McConkey DJ. Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells. Cancer Research. 65: 11510-9. PMID 16357160 DOI: 10.1158/0008-5472.Can-05-2394  0.371
2005 Banerjee S, Zhang Y, Ali S, Bhuiyan M, Wang Z, Chiao PJ, Philip PA, Abbruzzese J, Sarkar FH. Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Research. 65: 9064-72. PMID 16204081 DOI: 10.1158/0008-5472.Can-05-1330  0.564
2005 Yokoi K, Kim SJ, Thaker P, Yazici S, Nam DH, He J, Sasaki T, Chiao PJ, Sclabas GM, Abbruzzese JL, Hamilton SR, Fidler IJ. Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice. Neoplasia (New York, N.Y.). 7: 696-704. PMID 16026649 DOI: 10.1593/Neo.05193  0.427
2005 Qian J, Niu J, Li M, Chiao PJ, Tsao MS. In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis. Cancer Research. 65: 5045-53. PMID 15958547 DOI: 10.1158/0008-5472.Can-04-3208  0.707
2005 Sclabas GM, Uwagawa T, Schmidt C, Hess KR, Evans DB, Abbruzzese JL, Chiao PJ. Nuclear factor kappa B activation is a potential target for preventing pancreatic carcinoma by aspirin. Cancer. 103: 2485-90. PMID 15861417 DOI: 10.1002/Cncr.21075  0.456
2005 Zhu H, Zhang L, Dong F, Guo W, Wu S, Teraishi F, Davis JJ, Chiao PJ, Fang B. Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors. Oncogene. 24: 4993-9. PMID 15824729 DOI: 10.1038/Sj.Onc.1208683  0.416
2005 Gao Z, Chiao P, Zhang X, Zhang X, Lazar MA, Seto E, Young HA, Ye J. Coactivators and corepressors of NF-kappaB in IkappaB alpha gene promoter. The Journal of Biological Chemistry. 280: 21091-8. PMID 15811852 DOI: 10.1074/Jbc.M500754200  0.416
2005 Li Z, Niu J, Uwagawa T, Peng B, Chiao PJ. Function of polo-like kinase 3 in NF-kappaB-mediated proapoptotic response. The Journal of Biological Chemistry. 280: 16843-50. PMID 15671037 DOI: 10.1074/Jbc.M410119200  0.69
2005 Xiao Y, Zhong Y, Su H, Zhou Z, Chiao P, Zhong G. NF-kappa B activation is not required for Chlamydia trachomatis inhibition of host epithelial cell apoptosis. Journal of Immunology (Baltimore, Md. : 1950). 174: 1701-8. PMID 15661934 DOI: 10.4049/Jimmunol.174.3.1701  0.471
2004 Fujioka S, Niu J, Schmidt C, Sclabas GM, Peng B, Uwagawa T, Li Z, Evans DB, Abbruzzese JL, Chiao PJ. NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity. Molecular and Cellular Biology. 24: 7806-19. PMID 15314185 DOI: 10.1128/Mcb.24.17.7806-7819.2004  0.701
2004 Munshi A, Kurland JF, Nishikawa T, Chiao PJ, Andreeff M, Meyn RE. Inhibition of constitutively activated nuclear factor-kappaB radiosensitizes human melanoma cells. Molecular Cancer Therapeutics. 3: 985-92. PMID 15299081  0.406
2004 Li Z, Sclabas GM, Peng B, Hess KR, Abbruzzese JL, Evans DB, Chiao PJ. Overexpression of synuclein-gamma in pancreatic adenocarcinoma. Cancer. 101: 58-65. PMID 15221989 DOI: 10.1002/Cncr.20321  0.375
2004 Zhu H, Zhang L, Huang X, Davis JJ, Jacob DA, Teraishi F, Chiao P, Fang B. Overcoming acquired resistance to TRAIL by chemotherapeutic agents and calpain inhibitor I through distinct mechanisms. Molecular Therapy : the Journal of the American Society of Gene Therapy. 9: 666-73. PMID 15120327 DOI: 10.1016/J.Ymthe.2004.02.007  0.422
2004 Fujioka S, Schmidt C, Sclabas GM, Li Z, Pelicano H, Peng B, Yao A, Niu J, Zhang W, Evans DB, Abbruzzese JL, Huang P, Chiao PJ. Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB. The Journal of Biological Chemistry. 279: 27549-59. PMID 15102862 DOI: 10.1074/Jbc.M313435200  0.689
2004 Niu J, Li Z, Peng B, Chiao PJ. Identification of an autoregulatory feedback pathway involving interleukin-1alpha in induction of constitutive NF-kappaB activation in pancreatic cancer cells. The Journal of Biological Chemistry. 279: 16452-62. PMID 14679213 DOI: 10.1074/Jbc.M309789200  0.739
2003 Schmidt C, Peng B, Li Z, Sclabas GM, Fujioka S, Niu J, Schmidt-Supprian M, Evans DB, Abbruzzese JL, Chiao PJ. Mechanisms of proinflammatory cytokine-induced biphasic NF-kappaB activation. Molecular Cell. 12: 1287-300. PMID 14636585 DOI: 10.1016/S1097-2765(03)00390-3  0.675
2003 Sclabas GM, Fujioka S, Schmidt C, Evans DB, Chiao PJ. NF-kappaB in pancreatic cancer. International Journal of Gastrointestinal Cancer. 33: 15-26. PMID 12909735 DOI: 10.1385/Ijgc:33:1:15  0.478
2003 Fujioka S, Sclabas GM, Schmidt C, Niu J, Frederick WA, Dong QG, Abbruzzese JL, Evans DB, Baker C, Chiao PJ. Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis. Oncogene. 22: 1365-70. PMID 12618762 DOI: 10.1038/Sj.Onc.1206323  0.697
2003 Sclabas GM, Fujioka S, Schmidt C, Fan Z, Evans DB, Chiao PJ. Restoring apoptosis in pancreatic cancer cells by targeting the nuclear factor-kappaB signaling pathway with the anti-epidermal growth factor antibody IMC-C225. Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract. 7: 37-43; discussion 43. PMID 12559183 DOI: 10.1016/S1091-255X(02)00088-4  0.508
2003 Fujioka S, Sclabas GM, Schmidt C, Frederick WA, Dong QG, Abbruzzese JL, Evans DB, Baker C, Chiao PJ. Function of nuclear factor kappaB in pancreatic cancer metastasis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 346-54. PMID 12538487  0.384
2002 Peng B, Fleming JB, Breslin T, Grau AM, Fojioka S, Abbruzzese JL, Evans DB, Ayers D, Wathen K, Wu T, Robertson KD, Chiao PJ. Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 3628-38. PMID 12429655  0.317
2002 Chiao PJ, Na R, Niu J, Sclabas GM, Dong Q, Curley SA. Role of Rel/NF-kappaB transcription factors in apoptosis of human hepatocellular carcinoma cells. Cancer. 95: 1696-705. PMID 12365017 DOI: 10.1002/Cncr.10829  0.615
2002 Dong QG, Sclabas GM, Fujioka S, Schmidt C, Peng B, Wu T, Tsao MS, Evans DB, Abbruzzese JL, McDonnell TJ, Chiao PJ. The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis. Oncogene. 21: 6510-9. PMID 12226754 DOI: 10.1038/Sj.Onc.1205848  0.524
2002 Vorburger SA, Pataer A, Yoshida K, Barber GN, Xia W, Chiao P, Ellis LM, Hung MC, Swisher SG, Hunt KK. Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis. Oncogene. 21: 6278-88. PMID 12214268 DOI: 10.1038/Sj.Onc.1205761  0.436
2000 Pearson AS, Chiao P, Zhang L, Zhang W, Larry L, Katz RL, Evans DB, Abbruzzese JL. The detection of telomerase activity in patients with adenocarcinoma of the pancreas by fine needle aspiration. International Journal of Oncology. 17: 381-5. PMID 10891550 DOI: 10.3892/Ijo.17.2.381  0.413
2000 Wolff RA, Chiao P, Lenzi R, Pisters PWT, Lee JE, JanJan NA, Crane CH, Evans DB, Abbruzzese JL. Current approaches and future strategies for pancreatic carcinoma. Investigational New Drugs. 18: 43-56. PMID 10830140 DOI: 10.1023/A:1006383831045  0.343
1999 Bold RJ, Hess KR, Pearson AS, Grau AM, Sinicrope FA, Jennings M, McConkey DJ, Bucana CD, Cleary KR, Hallin PA, Chiao PJ, Abbruzzese JL, Evans DB. Prognostic Factors in Resectable Pancreatic Cancer: p53 and Bcl-2 Journal of Gastrointestinal Surgery. 3: 263-277. PMID 10481119 DOI: 10.1016/S1091-255X(99)80068-7  0.371
1999 Wang W, Abbruzzese JL, Evans DB, Chiao PJ. Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. Oncogene. 18: 4554-63. PMID 10467400 DOI: 10.1038/Sj.Onc.1202833  0.538
1999 Shao R, Hu MC, Zhou BP, Lin SY, Chiao PJ, von Lindern RH, Spohn B, Hung MC. E1A sensitizes cells to tumor necrosis factor-induced apoptosis through inhibition of IkappaB kinases and nuclear factor kappaB activities. The Journal of Biological Chemistry. 274: 21495-8. PMID 10419449 DOI: 10.1074/Jbc.274.31.21495  0.482
1999 Chiao PJ, Hunt KK, Grau AM, Abramian A, Fleming J, Zhang W, Breslin T, Abbruzzese JL, Evans DB. Tumor suppressor gene Smad4/DPC4, its downstream target genes, and regulation of cell cycle. Annals of the New York Academy of Sciences. 880: 31-7. PMID 10415848 DOI: 10.1111/J.1749-6632.1999.Tb09507.X  0.431
1999 Feig BW, Lu X, Hunt KK, Shan Q, Yu D, Pollock R, Chiao P. Inhibition of the transcription factor nuclear factor-κB by adenoviral-mediated expression of IκBαM results in tumor cell death Surgery. 126: 399-405. DOI: 10.1016/S0039-6060(99)70184-4  0.43
1998 Bouvet M, Bold RJ, Lee J, Evans DB, Abbruzzese JL, Chiao PJ, McConkey DJ, Chandra J, Chada S, Fang B, Roth JA. Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [seecomments]. Annals of Surgical Oncology. 5: 681-8. PMID 9869513 DOI: 10.1007/Bf02303477  0.434
1998 Robinson EK, Grau AM, Evans DB, Smid CM, Chiao PJ, Abbruzzese JL, Grimm EA. Cell cycle regulation of human pancreatic cancer by tamoxifen. Annals of Surgical Oncology. 5: 342-9. PMID 9641456 DOI: 10.1007/Bf02303498  0.436
1998 Deyo JE, Chiao PJ, Tainsky MA. drp, a novel protein expressed at high cell density but not during growth arrest Dna and Cell Biology. 17: 437-447. PMID 9628587 DOI: 10.1089/Dna.1998.17.437  0.602
1998 Shao R, Karunagaran D, Zhou BP, Li K, Lo SS, Deng J, Chiao P, Hung MC. Inhibition of nuclear factor-kappaB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis. The Journal of Biological Chemistry. 272: 32739-42. PMID 9407046 DOI: 10.1074/jbc.272.52.32739  0.327
1998 Miller AR, Robinson EK, Lee JE, Pisters PW, Chiao PJ, Lenzi R, Abbruzzese JL, Evans DB. Neoadjuvant Chemoradiation for Adenocarcinoma of the Pancreas Surgical Oncology Clinics of North America. 7: 183-197. DOI: 10.1016/S1055-3207(18)30293-X  0.319
1998 Bold R, Evans D, Hess K, Grau A, Sinicrope F, Cleary K, Chiao P, Abbruzzese J. Molecular genetics of pancreatic cancer Gastroenterology. 114: A1379. DOI: 10.1016/S0016-5085(98)85600-X  0.33
1997 Evans DB, Lee JE, Pisters PW, Charnsangavej C, Ellis LM, Chiao PJ, Lenzi R, Abbruzzese JL. Advances in the diagnosis and treatment of adenocarcinoma of the pancreas. Cancer Treatment and Research. 90: 109-25. PMID 9367080 DOI: 10.1007/978-1-4615-6165-1_6  0.312
1997 Balch G, Izzo F, Chiao P, Klostergaard J, Curley SA. Activation of human Kupffer cells by thymostimulin (TP-1) to produce cytotoxicity against human hepatocellular cancer. Annals of Surgical Oncology. 4: 149-55. PMID 9084852 DOI: 10.1007/Bf02303798  0.352
1994 Chiao PJ, Miyamoto S, Verma IM. Autoregulation of I kappa B alpha activity. Proceedings of the National Academy of Sciences of the United States of America. 91: 28-32. PMID 8278379 DOI: 10.1073/Pnas.91.1.28  0.339
1994 Miyamoto S, Chiao PJ, Verma IM. Enhanced I kappa B alpha degradation is responsible for constitutive NF-kappa B activity in mature murine B-cell lines. Molecular and Cellular Biology. 14: 3276-82. PMID 8164680 DOI: 10.1128/Mcb.14.5.3276  0.345
1994 Kannan P, Buettner R, Chiao PJ, Yim SO, Sarkiss M, Tainsky MA. N-ras oncogene causes AP-2 transcriptional self-interference, which leads to transformation. Genes & Development. 8: 1258-69. PMID 7926729 DOI: 10.1101/Gad.8.11.1258  0.615
1993 Shin DM, Chiao PJ, Sacks PG, Shin HJ, Hong WK, Hittelman WN, Tainsky MA. Activation of ribosomal protein S2 gene expression in a hamster model of chemically induced oral carcinogenesis. Carcinogenesis. 14: 163-6. PMID 8425267 DOI: 10.1093/Carcin/14.1.163  0.629
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