| Year |
Citation |
Score |
| 2024 |
Rebolledo EMD, Chan D, Christensen KE, Reagan AM, Howell GR, Rozen R, Trasler J. Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation. Molecular Human Reproduction. PMID 38366926 DOI: 10.1093/molehr/gaae008 |
0.321 |
|
| 2021 |
Luan Y, Leclerc D, Cosín-Tomás M, Malysheva OV, Wasek B, Bottiglieri T, Caudill MA, Rozen R. Moderate Folic Acid Supplementation in Pregnant Mice Results in Altered Methyl Metabolism and in Sex-specific Placental Transcription Changes. Molecular Nutrition & Food Research. e2100197. PMID 34010503 DOI: 10.1002/mnfr.202100197 |
0.301 |
|
| 2020 |
Cosín-Tomás M, Luan Y, Leclerc D, Malysheva OV, Lauzon N, Bahous RH, Christensen KE, Caudill MA, Rozen R. Moderate Folic Acid Supplementation in Pregnant Mice Results in Behavioral Alterations in Offspring with Sex-Specific Changes in Methyl Metabolism. Nutrients. 12. PMID 32521649 DOI: 10.3390/Nu12061716 |
0.38 |
|
| 2018 |
Leclerc D, Christensen KE, Cauvi O, Yang E, Fournelle F, Bahous RH, Malysheva OV, Deng L, Wu Q, Zhou Z, Zu-Hua G, Chaurand P, Caudill MA, Rozen R. Mild methylenetetrahydrofolate reductase deficiency alters inflammatory and lipid pathways in liver. Molecular Nutrition & Food Research. e1801001. PMID 30408316 DOI: 10.1002/Mnfr.201801001 |
0.352 |
|
| 2018 |
Bahous RH, Cosín-Tomás M, Deng L, Leclerc D, Malysheva O, Ho MK, Pallàs M, Kaliman P, Bedell BJ, Caudill MA, Rozen R. Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency. Molecular Neurobiology. PMID 30288696 DOI: 10.1007/S12035-018-1375-3 |
0.433 |
|
| 2018 |
Christensen KE, Bahous RH, Hou W, Deng L, Malysheva OV, Arning E, Bottiglieri T, Caudill MA, Jerome-Majewska LA, Rozen R. Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects. The Journal of Nutrition. 148: 501-509. PMID 29659962 DOI: 10.1093/Jn/Nxy013 |
0.403 |
|
| 2018 |
Aarabi M, Christensen KE, Chan D, Leclerc D, Landry M, Ly L, Rozen R, Trasler J. Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation. Human Molecular Genetics. PMID 29360980 DOI: 10.1093/Hmg/Ddy021 |
0.406 |
|
| 2017 |
Leclerc D, Pham DNT, Lévesque N, Truongcao M, Foulkes WD, Sapienza C, Rozen R. Oncogenic role of PDK4 in human colon cancer cells British Journal of Cancer. 116: 930-936. PMID 28208156 DOI: 10.1038/Bjc.2017.38 |
0.305 |
|
| 2017 |
Bahous RH, Jadavji NM, Deng L, Cosín-Tomás M, Lu J, Malysheva O, Leung KY, Ho MK, Pallàs M, Kaliman P, Greene N, Bedell BJ, Caudill MA, Rozen R. High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring. Human Molecular Genetics. PMID 28069796 DOI: 10.1093/Hmg/Ddx004 |
0.418 |
|
| 2016 |
Christensen KE, Hou W, Bahous RH, Deng L, Malysheva OV, Arning E, Bottiglieri T, Caudill MA, Jerome-Majewska LA, Rozen R. Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development. The American Journal of Clinical Nutrition. PMID 27707701 DOI: 10.3945/Ajcn.116.139519 |
0.389 |
|
| 2016 |
Lévesque N, Christensen KE, Van Der Kraak L, Best AF, Deng L, Caldwell D, MacFarlane AJ, Beauchemin N, Rozen R. Murine MTHFD1-synthetase deficiency, a model for the human MTHFD1 R653Q polymorphism, decreases growth of colorectal tumors. Molecular Carcinogenesis. PMID 27597531 DOI: 10.1002/Mc.22568 |
0.381 |
|
| 2016 |
Lévesque N, Leclerc D, Gayden T, Lazaris A, De Jay N, Petrillo S, Metrakos P, Jabado N, Rozen R. Murine diet/tissue and human brain tumorigenesis alter Mthfr/MTHFR 5'-end methylation. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 27: 122-34. PMID 26951114 DOI: 10.1007/S00335-016-9624-0 |
0.324 |
|
| 2015 |
Markand S, Saul A, Tawfik A, Cui X, Rozen R, Smith SB. Mthfr as a modifier of the retinal phenotype of Crb1(rd8/rd8) mice. Experimental Eye Research. PMID 26646559 DOI: 10.1016/J.Exer.2015.11.013 |
0.417 |
|
| 2015 |
Meadows DN, Bahous RH, Best AF, Rozen R. High Dietary Folate in Mice Alters Immune Response and Reduces Survival after Malarial Infection. Plos One. 10: e0143738. PMID 26599510 DOI: 10.1371/Journal.Pone.0143738 |
0.397 |
|
| 2015 |
Christensen KE, Deng L, Bahous RH, Jerome-Majewska LA, Rozen R. MTHFD1 formyltetrahydrofolate synthetase deficiency, a model for the MTHFD1 R653Q variant, leads to congenital heart defects in mice. Birth Defects Research. Part a, Clinical and Molecular Teratology. PMID 26408344 DOI: 10.1002/Bdra.23451 |
0.409 |
|
| 2015 |
Orozco LD, Morselli M, Rubbi L, Guo W, Go J, Shi H, Lopez D, Furlotte NA, Bennett BJ, Farber CR, Ghazalpour A, Zhang MQ, Bahous R, Rozen R, Lusis AJ, et al. Epigenome-wide association of liver methylation patterns and complex metabolic traits in mice. Cell Metabolism. 21: 905-17. PMID 26039453 DOI: 10.1016/J.Cmet.2015.04.025 |
0.333 |
|
| 2015 |
Jadavji NM, Deng L, Malysheva O, Caudill MA, Rozen R. MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring. Neuroscience. 300: 1-9. PMID 25956258 DOI: 10.1016/J.Neuroscience.2015.04.067 |
0.39 |
|
| 2015 |
Markand S, Saul A, Roon P, Prasad P, Martin P, Rozen R, Ganapathy V, Smith SB. Retinal Ganglion Cell Loss and Mild Vasculopathy in Methylene Tetrahydrofolate Reductase (Mthfr)-Deficient Mice: A Model of Mild Hyperhomocysteinemia. Investigative Ophthalmology & Visual Science. 56: 2684-95. PMID 25766590 DOI: 10.1167/Iovs.14-16190 |
0.366 |
|
| 2015 |
Christensen KE, Mikael LG, Leung KY, Lévesque N, Deng L, Wu Q, Malysheva OV, Best A, Caudill MA, Greene ND, Rozen R. High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice. The American Journal of Clinical Nutrition. 101: 646-58. PMID 25733650 DOI: 10.3945/Ajcn.114.086603 |
0.356 |
|
| 2014 |
Leclerc D, Dejgaard K, Mazur A, Deng L, Wu Q, Nilsson T, Rozen R. Quantitative proteomics reveals differentially expressed proteins in murine preneoplastic intestine in a model of intestinal tumorigenesis induced by low dietary folate and MTHFR deficiency. Proteomics. 14: 2558-65. PMID 25081070 DOI: 10.1002/Pmic.201400280 |
0.418 |
|
| 2014 |
Jadavji NM, Bahous RH, Deng L, Malysheva O, Grand'maison M, Bedell BJ, Caudill MA, Rozen R. Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism. The Biochemical Journal. 461: 205-12. PMID 24800750 DOI: 10.1042/Bj20131568 |
0.374 |
|
| 2014 |
Meadows DN, Pyzik M, Wu Q, Torre S, Gros P, Vidal SM, Rozen R. Increased resistance to malaria in mice with methylenetetrahydrofolate reductase (Mthfr) deficiency suggests a mechanism for selection of the MTHFR 677C>T (c.665C>T) variant. Human Mutation. 35: 594-600. PMID 24616178 DOI: 10.1002/Humu.22533 |
0.362 |
|
| 2013 |
Leclerc D, Lévesque N, Cao Y, Deng L, Wu Q, Powell J, Sapienza C, Rozen R. Genes with aberrant expression in murine preneoplastic intestine show epigenetic and expression changes in normal mucosa of colon cancer patients. Cancer Prevention Research (Philadelphia, Pa.). 6: 1171-81. PMID 24169962 DOI: 10.1158/1940-6207.Capr-13-0198 |
0.427 |
|
| 2013 |
Christensen KE, Deng L, Leung KY, Arning E, Bottiglieri T, Malysheva OV, Caudill MA, Krupenko NI, Greene ND, Jerome-Majewska L, MacKenzie RE, Rozen R. A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development Human Molecular Genetics. 22: 3705-3719. PMID 23704330 DOI: 10.1093/Hmg/Ddt223 |
0.408 |
|
| 2013 |
Mikael LG, Deng L, Paul L, Selhub J, Rozen R. Moderately high intake of folic acid has a negative impact on mouse embryonic development. Birth Defects Research. Part a, Clinical and Molecular Teratology. 97: 47-52. PMID 23125102 DOI: 10.1002/Bdra.23092 |
0.366 |
|
| 2013 |
Mikael LG, Pancer J, Jiang X, Wu Q, Caudill M, Rozen R. Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-γ in spleen and placenta, and through reduction of methylation potential. Molecular Nutrition & Food Research. 57: 661-70. PMID 23112124 DOI: 10.1002/Mnfr.201200152 |
0.335 |
|
| 2013 |
Leclerc D, Cao Y, Deng L, Mikael LG, Wu Q, Rozen R. Differential gene expression and methylation in the retinoid/PPARA pathway and of tumor suppressors may modify intestinal tumorigenesis induced by low folate in mice. Molecular Nutrition & Food Research. 57: 686-97. PMID 23001810 DOI: 10.1002/Mnfr.201200212 |
0.458 |
|
| 2013 |
Christensen KE, Zada YF, Rohlicek CV, Andelfinger GU, Michaud JL, Bigras JL, Richter A, Dubé MP, Rozen R. Risk of congenital heart defects is influenced by genetic variation in folate metabolism. Cardiology in the Young. 23: 89-98. PMID 22475273 DOI: 10.1017/S1047951112000431 |
0.319 |
|
| 2012 |
Saferali A, Moussette S, Chan D, Trasler J, Chen T, Rozen R, Naumova AK. DNA methyltransferase 1 (Dnmt1) mutation affects Snrpn imprinting in the mouse male germ line. Genome / National Research Council Canada = GéNome / Conseil National De Recherches Canada. 55: 673-82. PMID 22967183 DOI: 10.1139/G2012-056 |
0.362 |
|
| 2012 |
Jadavji NM, Deng L, Leclerc D, Malysheva O, Bedell BJ, Caudill MA, Rozen R. Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus. Molecular Genetics and Metabolism. 106: 149-59. PMID 22521626 DOI: 10.1016/J.Ymgme.2012.03.020 |
0.405 |
|
| 2012 |
Mikael LG, Pancer J, Wu Q, Rozen R. Disturbed one-carbon metabolism causing adverse reproductive outcomes in mice is associated with altered expression of apolipoprotein AI and inflammatory mediators PPARα, interferon-γ, and interleukin-10. The Journal of Nutrition. 142: 411-8. PMID 22259189 DOI: 10.3945/Jn.111.151753 |
0.445 |
|
| 2011 |
Pickell L, Wu Q, Wang XL, Leclerc D, Friedman H, Peterson AC, Rozen R. Targeted insertion of two Mthfr promoters in mice reveals temporal- and tissue-specific regulation. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 22: 635-47. PMID 21769670 DOI: 10.1007/S00335-011-9351-5 |
0.361 |
|
| 2011 |
Pickell L, Brown K, Li D, Wang XL, Deng L, Wu Q, Selhub J, Luo L, Jerome-Majewska L, Rozen R. High intake of folic acid disrupts embryonic development in mice. Birth Defects Research. Part a, Clinical and Molecular Teratology. 91: 8-19. PMID 21254354 DOI: 10.1002/Bdra.20754 |
0.411 |
|
| 2011 |
Knock E, Deng L, Krupenko N, Mohan RD, Wu Q, Leclerc D, Gupta S, Elmore CL, Kruger W, Tini M, Rozen R. Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair. The Journal of Nutritional Biochemistry. 22: 1022-9. PMID 21193302 DOI: 10.1016/J.Jnutbio.2010.07.015 |
0.799 |
|
| 2011 |
Lawrance AK, Racine J, Deng L, Wang X, Lachapelle P, Rozen R. Complete deficiency of methylenetetrahydrofolate reductase in mice is associated with impaired retinal function and variable mortality, hematological profiles, and reproductive outcomes. Journal of Inherited Metabolic Disease. 34: 147-57. PMID 20532821 DOI: 10.1007/S10545-010-9127-1 |
0.453 |
|
| 2010 |
Strakova J, Williams KT, Gupta S, Schalinske KL, Kruger WD, Rozen R, Jiracek J, Li L, Garrow TA. Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats. Nutrition Research (New York, N.Y.). 30: 492-500. PMID 20797482 DOI: 10.1016/J.Nutres.2010.06.017 |
0.36 |
|
| 2010 |
Christensen KE, Wu Q, Wang X, Deng L, Caudill MA, Rozen R. Steatosis in mice is associated with gender, folate intake, and expression of genes of one-carbon metabolism. The Journal of Nutrition. 140: 1736-41. PMID 20724492 DOI: 10.3945/Jn.110.124917 |
0.405 |
|
| 2010 |
Maclean KN, Sikora J, Kožich V, Jiang H, Greiner LS, Kraus E, Krijt J, Overdier KH, Collard R, Brodsky GL, Meltesen L, Crnic LS, Allen RH, Stabler SP, Elleder M, ... Rozen R, et al. A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment. Molecular Genetics and Metabolism. 101: 153-62. PMID 20638879 DOI: 10.1016/J.Ymgme.2010.06.010 |
0.412 |
|
| 2010 |
De Castro SC, Leung KY, Savery D, Burren K, Rozen R, Copp AJ, Greene ND. Neural tube defects induced by folate deficiency in mutant curly tail (Grhl3) embryos are associated with alteration in folate one-carbon metabolism but are unlikely to result from diminished methylation. Birth Defects Research. Part a, Clinical and Molecular Teratology. 88: 612-8. PMID 20589880 DOI: 10.1002/Bdra.20690 |
0.349 |
|
| 2010 |
Chan D, Cushnie DW, Neaga OR, Lawrance AK, Rozen R, Trasler JM. Strain-specific defects in testicular development and sperm epigenetic patterns in 5,10-methylenetetrahydrofolate reductase-deficient mice. Endocrinology. 151: 3363-73. PMID 20444942 DOI: 10.1210/En.2009-1340 |
0.458 |
|
| 2010 |
Rozen R. Biochemistry and genetics of folate metabolism Cerebrospinal Fluid Research. 7. DOI: 10.1186/1743-8454-7-S1-S4 |
0.407 |
|
| 2010 |
Landry M, Chan D, Martel J, Rozen R, Trasler J. Folate Deficiency and Supplementation Result in DNA Methylation Defects in Sperm. Biology of Reproduction. 83: 308-308. DOI: 10.1093/Biolreprod/83.S1.308 |
0.333 |
|
| 2009 |
Fodil-Cornu N, Kozij N, Wu Q, Rozen R, Vidal SM. Methylenetetrahydrofolate reductase (MTHFR) deficiency enhances resistance against cytomegalovirus infection. Genes and Immunity. 10: 662-6. PMID 19609317 DOI: 10.1038/Gene.2009.50 |
0.402 |
|
| 2009 |
Celtikci B, Lawrance AK, Wu Q, Rozen R. Methotrexate-induced apoptosis is enhanced by altered expression of methylenetetrahydrofolate reductase. Anti-Cancer Drugs. 20: 787-93. PMID 19593106 DOI: 10.1097/Cad.0B013E32832F4Aa8 |
0.443 |
|
| 2009 |
Mikael LG, Wang XL, Wu Q, Jiang H, Maclean KN, Rozen R. Hyperhomocysteinemia is associated with hypertriglyceridemia in mice with methylenetetrahydrofolate reductase deficiency. Molecular Genetics and Metabolism. 98: 187-94. PMID 19560954 DOI: 10.1016/J.Ymgme.2009.05.011 |
0.421 |
|
| 2009 |
Pickell L, Li D, Brown K, Mikael LG, Wang XL, Wu Q, Luo L, Jerome-Majewska L, Rozen R. Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in mice. Birth Defects Research. Part a, Clinical and Molecular Teratology. 85: 531-41. PMID 19215022 DOI: 10.1002/Bdra.20575 |
0.436 |
|
| 2009 |
Garcia-Crespo D, Knock E, Jabado N, Rozen R. Intestinal neoplasia induced by low dietary folate is associated with altered tumor expression profiles and decreased apoptosis in mouse normal intestine. The Journal of Nutrition. 139: 488-94. PMID 19176749 DOI: 10.3945/Jn.108.095661 |
0.778 |
|
| 2009 |
Lawrance AK, Deng L, Rozen R. Methylenetetrahydrofolate reductase deficiency and low dietary folate reduce tumorigenesis in Apc min/+ mice. Gut. 58: 805-11. PMID 19174418 DOI: 10.1136/Gut.2007.143107 |
0.395 |
|
| 2009 |
Christensen KE, Rohlicek CV, Andelfinger GU, Michaud J, Bigras JL, Richter A, Mackenzie RE, Rozen R. The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects. Human Mutation. 30: 212-20. PMID 18767138 DOI: 10.1002/Humu.20830 |
0.373 |
|
| 2009 |
Kahn SR, Platt R, McNamara H, Rozen R, Chen MF, Genest J, Goulet L, Lydon J, Seguin L, Dassa C, Masse A, Asselin G, Benjamin A, Miner L, Ghanem A, et al. Inherited thrombophilia and preeclampsia within a multicenter cohort: The montreal preeclampsia study Obstetrical and Gynecological Survey. 64: 366-368. DOI: 10.1097/01.Ogx.0000350209.69577.38 |
0.301 |
|
| 2008 |
Roy M, Leclerc D, Wu Q, Gupta S, Kruger WD, Rozen R. Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency. Journal of Cellular Biochemistry. 105: 467-76. PMID 18615588 DOI: 10.1002/Jcb.21847 |
0.456 |
|
| 2008 |
Celtikci B, Leclerc D, Lawrance AK, Deng L, Friedman HC, Krupenko NI, Krupenko SA, Melnyk S, James SJ, Peterson AC, Rozen R. Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice. Pharmacogenetics and Genomics. 18: 577-89. PMID 18551038 DOI: 10.1097/Fpc.0B013E32830058Aa |
0.419 |
|
| 2008 |
Deng L, Elmore CL, Lawrance AK, Matthews RG, Rozen R. Methionine synthase reductase deficiency results in adverse reproductive outcomes and congenital heart defects in mice. Molecular Genetics and Metabolism. 94: 336-42. PMID 18413293 DOI: 10.1016/J.Ymgme.2008.03.004 |
0.42 |
|
| 2008 |
Chan A, Tchantchou F, Graves V, Rozen R, Shea TB. Dietary and genetic compromise in folate availability reduces acetylcholine, cognitive performance and increases aggression: critical role of S-adenosyl methionine. The Journal of Nutrition, Health & Aging. 12: 252-61. PMID 18373034 DOI: 10.1007/Bf02982630 |
0.405 |
|
| 2008 |
Knock E, Deng L, Wu Q, Lawrance AK, Wang XL, Rozen R. Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate. The Journal of Nutrition. 138: 653-8. PMID 18356316 DOI: 10.1093/Jn/138.4.653 |
0.79 |
|
| 2008 |
Leclerc D, Rozen R. Endoplasmic reticulum stress increases the expression of methylenetetrahydrofolate reductase through the IRE1 transducer. The Journal of Biological Chemistry. 283: 3151-60. PMID 18065414 DOI: 10.1074/Jbc.M708598200 |
0.325 |
|
| 2007 |
Ananth CV, Peltier MR, De Marco C, Elsasser DA, Getahun D, Rozen R, Smulian JC. Associations between 2 polymorphisms in the methylenetetrahydrofolate reductase gene and placental abruption. American Journal of Obstetrics and Gynecology. 197: 385.e1-7. PMID 17904970 DOI: 10.1016/J.Ajog.2007.06.046 |
0.331 |
|
| 2007 |
Schwahn BC, Wang XL, Mikael LG, Wu Q, Cohn J, Jiang H, Maclean KN, Rozen R. Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia. Atherosclerosis. 195: e100-7. PMID 17689540 DOI: 10.1016/J.Atherosclerosis.2007.06.030 |
0.311 |
|
| 2007 |
Elmore CL, Wu X, Leclerc D, Watson ED, Bottiglieri T, Krupenko NI, Krupenko SA, Cross JC, Rozen R, Gravel RA, Matthews RG. Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Molecular Genetics and Metabolism. 91: 85-97. PMID 17369066 DOI: 10.1016/J.Ymgme.2007.02.001 |
0.447 |
|
| 2007 |
Leclerc D, Rozen R. [Molecular genetics of MTHFR: polymorphisms are not all benign]. MéDecine Sciences : M/S. 23: 297-302. PMID 17349292 DOI: 10.1051/Medsci/2007233297 |
0.411 |
|
| 2007 |
Lawrance AK, Deng L, Brody LC, Finnell RH, Shane B, Rozen R. Genetic and nutritional deficiencies in folate metabolism influence tumorigenicity in Apcmin/+ mice. The Journal of Nutritional Biochemistry. 18: 305-12. PMID 16963246 DOI: 10.1016/J.Jnutbio.2006.06.001 |
0.5 |
|
| 2007 |
Savoia C, Lemarie CA, Touyz RM, Rozen R, Volpe M, Schiffrin EL. Peroxisome Proliferator-Activated Receptors Activator, Rosiglitazone, Improves Vascular Structure and Reduces Lipid Deposition in Atherosclerotic Mthfr Knock-Out Mice High Blood Pressure & Cardiovascular Prevention. 14: 145-196. DOI: 10.2165/00151642-200714030-00180 |
0.32 |
|
| 2006 |
Knock E, Deng L, Wu Q, Leclerc D, Wang XL, Rozen R. Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c. Cancer Research. 66: 10349-56. PMID 17079455 DOI: 10.1158/0008-5472.Can-06-2477 |
0.807 |
|
| 2006 |
Li D, Rozen R. Maternal folate deficiency affects proliferation, but not apoptosis, in embryonic mouse heart. The Journal of Nutrition. 136: 1774-8. PMID 16772436 DOI: 10.1093/Jn/136.7.1774 |
0.374 |
|
| 2006 |
Mikael LG, Genest J, Rozen R. Elevated homocysteine reduces apolipoprotein A-I expression in hyperhomocysteinemic mice and in males with coronary artery disease. Circulation Research. 98: 564-71. PMID 16439690 DOI: 10.1161/01.Res.0000204825.66410.0B |
0.428 |
|
| 2006 |
Li D, Pickell L, Liu Y, Rozen R. Impact of methylenetetrahydrofolate reductase deficiency and low dietary folate on the development of neural tube defects in splotch mice. Birth Defects Research. Part a, Clinical and Molecular Teratology. 76: 55-9. PMID 16397891 DOI: 10.1002/Bdra.20223 |
0.411 |
|
| 2006 |
Ananth C, Kinzler W, Peltier M, Elsasser D, Getahun D, Rozen R. Risk of placental abruption in relation to variants in betaine-homocysteine S-Methyltransferase and methionine synthase reductase genes: The New Jersey-Placental Abruption Study American Journal of Obstetrics and Gynecology. 195: S87. DOI: 10.1016/J.Ajog.2006.10.282 |
0.311 |
|
| 2006 |
Ananth C, Peltier M, Demarco C, Getahun D, Rozen R, Smulian J. Polymorphisms of the methylenetetrahydrofolate reductase gene and placental abruption: The New Jersey-Placental Abruption Study American Journal of Obstetrics and Gynecology. 195: S87. DOI: 10.1016/J.Ajog.2006.10.281 |
0.326 |
|
| 2005 |
Li D, Pickell L, Liu Y, Wu Q, Cohn JS, Rozen R. Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in mice. The American Journal of Clinical Nutrition. 82: 188-95. PMID 16002818 DOI: 10.1093/Ajcn.82.1.188 |
0.39 |
|
| 2005 |
Chen Z, Schwahn BC, Wu Q, He X, Rozen R. Postnatal cerebellar defects in mice deficient in methylenetetrahydrofolate reductase. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 23: 465-74. PMID 15979267 DOI: 10.1016/J.Ijdevneu.2005.05.007 |
0.778 |
|
| 2005 |
Morel CF, Scott P, Christensen E, Rosenblatt DS, Rozen R. Prenatal diagnosis for severe methylenetetrahydrofolate reductase deficiency by linkage analysis and enzymatic assay. Molecular Genetics and Metabolism. 85: 115-20. PMID 15896655 DOI: 10.1016/J.Ymgme.2005.03.001 |
0.332 |
|
| 2005 |
Boutros M, Vicanek C, Rozen R, Goodyer P. Transient neonatal cystinuria. Kidney International. 67: 443-8. PMID 15673291 DOI: 10.1111/J.1523-1755.2005.67100.X |
0.31 |
|
| 2005 |
Kelly TL, Neaga OR, Schwahn BC, Rozen R, Trasler JM. Infertility in 5,10-methylenetetrahydrofolate reductase (MTHFR)-deficient male mice is partially alleviated by lifetime dietary betaine supplementation. Biology of Reproduction. 72: 667-77. PMID 15548731 DOI: 10.1095/Biolreprod.104.035238 |
0.42 |
|
| 2004 |
Ghandour H, Chen Z, Selhub J, Rozen R. Mice deficient in methylenetetrahydrofolate reductase exhibit tissue-specific distribution of folates Journal of Nutrition. 134: 2975-2978. PMID 15514261 DOI: 10.1093/Jn/134.11.2975 |
0.785 |
|
| 2004 |
Leclerc D, Deng L, Trasler J, Rozen R. ApcMin/+ mouse model of colon cancer: gene expression profiling in tumors. Journal of Cellular Biochemistry. 93: 1242-54. PMID 15486983 DOI: 10.1002/Jcb.20236 |
0.356 |
|
| 2004 |
Schwahn BC, Laryea MD, Chen Z, Melnyk S, Pogribny I, Garrow T, James SJ, Rozen R. Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency. The Biochemical Journal. 382: 831-40. PMID 15217352 DOI: 10.1042/BJ20040822 |
0.776 |
|
| 2004 |
Schwahn BC, Wendel U, Lussier-Cacan S, Mar MH, Zeisel SH, Leclerc D, Castro C, Garrow TA, Rozen R. Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency. Metabolism: Clinical and Experimental. 53: 594-9. PMID 15131763 DOI: 10.1016/J.Metabol.2003.10.033 |
0.466 |
|
| 2004 |
Neves MF, Endemann D, Amiri F, Virdis A, Pu Q, Rozen R, Schiffrin EL. Small artery mechanics in hyperhomocysteinemic mice: effects of angiotensin II. Journal of Hypertension. 22: 959-66. PMID 15097236 DOI: 10.1097/00004872-200405000-00018 |
0.308 |
|
| 2004 |
Devlin AM, Arning E, Bottiglieri T, Faraci FM, Rozen R, Lentz SR. Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice Blood. 103: 2624-2629. PMID 14630804 DOI: 10.1182/Blood-2003-09-3078 |
0.434 |
|
| 2004 |
ROZEN R. Folate and Genetics Journal of Food Science. 69: SNQ65-SNQ67. DOI: 10.1111/J.1365-2621.2004.Tb17890.X |
0.429 |
|
| 2004 |
SCHWAHN B, LARYEA M, CHEN Z, MELNYK S, POGRIBNY I, GARROW T, JAMES S, ROZEN R. Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency Biochemical Journal. 382: 831-840. DOI: 10.1042/Bj20030822 |
0.781 |
|
| 2003 |
Spotila LD, Jacques PF, Berger PB, Ballman KV, Ellison RC, Rozen R. Age dependence of the influence of methylenetetrahydrofolate reductase genotype on plasma homocysteine level. American Journal of Epidemiology. 158: 871-7. PMID 14585765 DOI: 10.1093/Aje/Kwg234 |
0.365 |
|
| 2003 |
Leclerc D, Darwich-Codore H, Rozen R. Characterization of a pseudogene for murine methylenetetrahydrofolate reductase. Molecular and Cellular Biochemistry. 252: 391-5. PMID 14577615 DOI: 10.1023/A:1025540304067 |
0.342 |
|
| 2003 |
Morin I, Devlin AM, Leclerc D, Sabbaghian N, Halsted CH, Finnell R, Rozen R. Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk Molecular Genetics and Metabolism. 79: 197-200. PMID 12855225 DOI: 10.1016/S1096-7192(03)00086-6 |
0.372 |
|
| 2003 |
Virdis A, Iglarz M, Neves MF, Amiri F, Touyz RM, Rozen R, Schiffrin EL. Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 1352-7. PMID 12829522 DOI: 10.1161/01.Atv.0000083297.47245.Da |
0.353 |
|
| 2003 |
Weisberg IS, Park E, Ballman KV, Berger P, Nunn M, Suh DS, Breksa AP, Garrow TA, Rozen R. Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease. Atherosclerosis. 167: 205-14. PMID 12818402 DOI: 10.1016/S0021-9150(03)00010-8 |
0.337 |
|
| 2003 |
Morin I, Platt R, Weisberg I, Sabbaghian N, Wu Q, Garrow TA, Rozen R. Common variant in betaine-homocysteine methyltransferase (BHMT) and risk for spina bifida. American Journal of Medical Genetics. Part A. 119: 172-6. PMID 12749058 DOI: 10.1002/Ajmg.A.20115 |
0.334 |
|
| 2003 |
Sibani S, Leclerc D, Weisberg IS, O'Ferrall E, Watkins D, Artigas C, Rosenblatt DS, Rozen R. Characterization of mutations in severe methylenetetrahydrofolate reductase deficiency reveals an FAD-responsive mutation. Human Mutation. 21: 509-20. PMID 12673793 DOI: 10.1002/Humu.10193 |
0.365 |
|
| 2003 |
Schwahn BC, Chen Z, Laryea MD, Wendel U, Lussier-Cacan S, Genest J, Mar MH, Zeisel SH, Castro C, Garrow T, Rozen R. Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 512-4. PMID 12551843 DOI: 10.1096/Fj.02-0456Fje |
0.796 |
|
| 2003 |
Trasler J, Deng L, Melnyk S, Pogribny I, Hiou-Tim F, Sibani S, Oakes C, Li E, James SJ, Rozen R. Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice. Carcinogenesis. 24: 39-45. PMID 12538347 DOI: 10.1093/Carcin/24.1.39 |
0.454 |
|
| 2003 |
Jacques PF, Bostom AG, Selhub J, Rich S, Ellison RC, Eckfeldt JH, Gravel RA, Rozen R. Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study. Atherosclerosis. 166: 49-55. PMID 12482550 DOI: 10.1016/S0021-9150(02)00204-6 |
0.386 |
|
| 2002 |
Chen Z, Ge B, Hudson TJ, Rozen R. Microarray analysis of brain RNA in mice with methylenetetrahydrofolate reductase deficiency and hyperhomocysteinemia Brain Research. Gene Expression Patterns. 1: 89-93. PMID 15018804 DOI: 10.1016/S1567-133X(01)00018-7 |
0.757 |
|
| 2002 |
Tran P, Leclerc D, Chan M, Pai A, Hiou-Tim F, Wu Q, Goyette P, Artigas C, Milos R, Rozen R. Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 13: 483-92. PMID 12370778 DOI: 10.1007/S00335-002-2167-6 |
0.335 |
|
| 2002 |
Tran P, Hiou-Tim F, Frosst P, Lussier-Cacan S, Bagley P, Selhub J, Bottiglieri T, Rozen R. The curly-tail (ct) mouse, an animal model of neural tube defects, displays altered homocysteine metabolism without folate responsiveness or a defect in Mthfr. Molecular Genetics and Metabolism. 76: 297-304. PMID 12208134 DOI: 10.1016/S1096-7192(02)00108-7 |
0.398 |
|
| 2002 |
Rozen R. Methylenetetrahydrofolate reductase: a link between folate and riboflavin? The American Journal of Clinical Nutrition. 76: 301-2. PMID 12144998 DOI: 10.1093/Ajcn/76.2.301 |
0.311 |
|
| 2002 |
Schwahn B, Rozen R. Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences. American Journal of Pharmacogenomics : Genomics-Related Research in Drug Development and Clinical Practice. 1: 189-201. PMID 12083967 DOI: 10.2165/00129785-200101030-00004 |
0.381 |
|
| 2002 |
Sibani S, Melnyk S, Pogribny IP, Wang W, Hiou-Tim F, Deng L, Trasler J, James SJ, Rozen R. Studies of methionine cycle intermediates (SAM, SAH), DNA methylation and the impact of folate deficiency on tumor numbers in Min mice. Carcinogenesis. 23: 61-5. PMID 11756224 DOI: 10.1093/Carcin/23.1.61 |
0.401 |
|
| 2001 |
Yamada K, Chen Z, Rozen R, Matthews RG. Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase. Proceedings of the National Academy of Sciences of the United States of America. 98: 14853-8. PMID 11742092 DOI: 10.1073/Pnas.261469998 |
0.757 |
|
| 2001 |
Mudd SH, Cerone R, Schiaffino MC, Fantasia AR, Minniti G, Caruso U, Lorini R, Watkins D, Matiaszuk N, Rosenblatt DS, Schwahn B, Rozen R, LeGros L, Kotb M, Capdevila A, et al. Glycine N-methyltransferase deficiency: a novel inborn error causing persistent isolated hypermethioninaemia. Journal of Inherited Metabolic Disease. 24: 448-64. PMID 11596649 DOI: 10.1023/A:1010577512912 |
0.373 |
|
| 2001 |
Kramer MS, Goulet L, Lydon J, Séguin L, McNamara H, Dassa C, Platt RW, Chen MF, Gauthier H, Genest J, Kahn S, Libman M, Rozen R, Masse A, Miner L, et al. Socio-economic disparities in preterm birth: causal pathways and mechanisms. Paediatric and Perinatal Epidemiology. 104-23. PMID 11520404 DOI: 10.1046/J.1365-3016.2001.00012.X |
0.304 |
|
| 2001 |
Leclerc D, Wu Q, Ellis JR, Goodyer P, Rozen R. Is the SLC7A10 gene on chromosome 19 a candidate locus for cystinuria Molecular Genetics and Metabolism. 73: 333-339. PMID 11509015 DOI: 10.1006/Mgme.2001.3209 |
0.326 |
|
| 2001 |
Weisberg IS, Jacques PF, Selhub J, Bostom AG, Chen Z, Curtis Ellison R, Eckfeldt JH, Rozen R. The 1298A → C polymorphism in methylenetetrahydrofolate reductase (MTHFR): In vitro expression and association with homocysteine Atherosclerosis. 156: 409-415. PMID 11395038 DOI: 10.1016/S0021-9150(00)00671-7 |
0.753 |
|
| 2001 |
Chen Z, Karaplis AC, Ackerman SL, Pogribny IP, Melnyk S, Lussier-Cacan S, Chen MF, Pai A, John SW, Smith RS, Bottiglieri T, Bagley P, Selhub J, Rudnicki MA, James SJ, ... Rozen R, et al. Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition. Human Molecular Genetics. 10: 433-43. PMID 11181567 DOI: 10.1093/Hmg/10.5.433 |
0.795 |
|
| 2001 |
Rozen R. Genetic modulation of homocysteinemia. Seminars in Thrombosis and Hemostasis. 26: 255-61. PMID 11011843 DOI: 10.1055/S-2000-8470 |
0.388 |
|
| 2000 |
Brown CA, McKinney KQ, Kaufman JS, Gravel RA, Rozen R. A common polymorphism in methionine synthase reductase increases risk of premature coronary artery disease. Journal of Cardiovascular Risk. 7: 197-200. PMID 11006889 DOI: 10.1177/204748730000700306 |
0.341 |
|
| 2000 |
Hobbs CA, Sherman SL, Yi P, Hopkins SE, Torfs CP, Hine RJ, Pogribna M, Rozen R, James SJ. Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome. American Journal of Human Genetics. 67: 623-30. PMID 10930360 DOI: 10.1086/303055 |
0.352 |
|
| 2000 |
Goyette P, Rozen R. The thermolabile variant 677C-->T can further reduce activity when expressed in cis with severe mutations for human methylenetetrahydrofolate reductase. Human Mutation. 16: 132-8. PMID 10923034 DOI: 10.1002/1098-1004(200008)16:2<132::Aid-Humu5>3.0.Co;2-T |
0.384 |
|
| 2000 |
Goodyer P, Boutros M, Rozen R. The molecular basis of cystinuria: An update Experimental Nephrology. 8: 123-127. PMID 10810228 DOI: 10.1159/000020659 |
0.341 |
|
| 2000 |
Sibani S, Christensen B, O'Ferrall E, Saadi I, Hiou-Tim F, Rosenblatt DS, Rozen R. Characterization of six novel mutations in the methylenetetrahydrofolate reductase (MTHFR) gene in patients with homocystinuria. Human Mutation. 15: 280-7. PMID 10679944 DOI: 10.1002/(Sici)1098-1004(200003)15:3<280::Aid-Humu9>3.0.Co;2-I |
0.362 |
|
| 2000 |
Rajkovic A, Mahomed K, Rozen R, Malinow MR, King IB, Williams MA. Methylenetetrahydrofolate reductase 677 C --> T polymorphism, plasma folate, vitamin B(12) concentrations, and risk of preeclampsia among black African women from Zimbabwe. Molecular Genetics and Metabolism. 69: 33-9. PMID 10655155 DOI: 10.1006/Mgme.1999.2952 |
0.344 |
|
| 1999 |
Wilson A, Platt R, Wu Q, Leclerc D, Christensen B, Yang H, Gravel RA, Rozen R. A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. Molecular Genetics and Metabolism. 67: 317-23. PMID 10444342 DOI: 10.1006/Mgme.1999.2879 |
0.386 |
|
| 1999 |
Christensen B, Arbour L, Tran P, Leclerc D, Sabbaghian N, Platt R, Gilfix BM, Rosenblatt DS, Gravel RA, Forbes P, Rozen R. Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects. American Journal of Medical Genetics. 84: 151-7. PMID 10323741 DOI: 10.1002/(Sici)1096-8628(19990521)84:2<151::Aid-Ajmg12>3.0.Co;2-T |
0.326 |
|
| 1999 |
Guenther BD, Sheppard CA, Tran P, Rozen R, Matthews RG, Ludwig ML. The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia. Nature Structural Biology. 6: 359-65. PMID 10201405 DOI: 10.1038/7594 |
0.374 |
|
| 1998 |
Weisberg I, Tran P, Christensen B, Sibani S, Rozen R. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Molecular Genetics and Metabolism. 64: 169-72. PMID 9719624 DOI: 10.1006/Mgme.1998.2714 |
0.348 |
|
| 1998 |
Goyette P, Pai A, Milos R, Frosst P, Tran P, Chen Z, Chan M, Rozen R. Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR) Mammalian Genome : Official Journal of the International Mammalian Genome Society. 9: 652-6. PMID 9680386 DOI: 10.1007/S003359900838 |
0.747 |
|
| 1998 |
Shaw GM, Rozen R, Finnell RH, Wasserman CR, Lammer EJ. Maternal vitamin use, genetic variation of infant methylenetetrahydrofolate reductase, and risk for spina bifida. American Journal of Epidemiology. 148: 30-7. PMID 9663401 DOI: 10.1093/Oxfordjournals.Aje.A009555 |
0.307 |
|
| 1998 |
Saadi I, Chen XZ, Hediger M, Ong P, Pereira P, Goodyer P, Rozen R. Molecular genetics of cystinuria: mutation analysis of SLC3A1 and evidence for another gene in type I (silent) phenotype. Kidney International. 54: 48-55. PMID 9648062 DOI: 10.1046/J.1523-1755.1998.00956.X |
0.344 |
|
| 1997 |
Christensen B, Frosst P, Lussier-Cacan S, Selhub J, Goyette P, Rosenblatt DS, Genest J, Rozen R. Correlation of a common mutation in the methylenetetrahydrofolate reductase gene with plasma homocysteine in patients with premature coronary artery disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 569-73. PMID 9102178 DOI: 10.1161/01.Atv.17.3.569 |
0.362 |
|
| 1997 |
Leclerc D, Campeau E, Goyette P, Adjalla CE, Christensen B, Ross M, Eydoux P, Rosenblatt DS, Rozen R, Gravel RA. Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders. Human Molecular Genetics. 5: 1867-74. PMID 8968737 DOI: 10.1093/Hmg/5.12.1867 |
0.356 |
|
| 1997 |
Rozen R. Molecular genetics of methylenetetrahydrofolate reductase deficiency. Journal of Inherited Metabolic Disease. 19: 589-94. PMID 8892013 DOI: 10.1007/Bf01799831 |
0.373 |
|
| 1997 |
Frosst P, Zhang Z, Pai A, Rozen R. The methylenetetrahydrofolate reductase (Mthfr) gene maps to distal mouse chromosome 4. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 7: 864-5. PMID 8875901 DOI: 10.1007/S003359900255 |
0.368 |
|
| 1997 |
Rozen R. Genetic Predisposition to Hyperhomocysteinemia: Deficiency of Methylenetetrahydrofolate Reductase (MTHFR) Thrombosis and Haemostasis. 78: 523-526. DOI: 10.1055/S-0038-1657581 |
0.318 |
|
| 1996 |
Ou CY, Stevenson RE, Brown VK, Schwartz CE, Allen WP, Khoury MJ, Rozen R, Oakley GP, Adams MJ. 5,10 Methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects. American Journal of Medical Genetics. 63: 610-4. PMID 8826441 DOI: 10.1002/(Sici)1096-8628(19960628)63:4<610::Aid-Ajmg15>3.0.Co;2-L |
0.388 |
|
| 1996 |
Bostom AG, Shemin D, Lapane KL, Nadeau MR, Sutherland P, Chan J, Rozen R, Yoburn D, Jacques PF, Selhub J, Rosenberg IH. Folate status is the major determinant of fasting total plasma homocysteine levels in maintenance dialysis patients Atherosclerosis. 123: 193-202. PMID 8782850 DOI: 10.1016/0021-9150(96)05809-1 |
0.341 |
|
| 1996 |
Horsford J, Saadi I, Raelson J, Goodyer PR, Rozen R. Molecular genetics of cystinuria in French Canadians: identification of four novel mutations in type I patients. Kidney International. 49: 1401-6. PMID 8731106 DOI: 10.1038/Ki.1996.197 |
0.327 |
|
| 1996 |
Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, Selhub J, Rozen R. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation. 93: 7-9. PMID 8616944 DOI: 10.1161/01.Cir.93.1.7 |
0.347 |
|
| 1996 |
Christensen B, Goyette P, Al-Hendy A, Rosenblatt DS, Rozen R. NEW MUTATION IDENTIFIED IN FOUR UNRELATED PATIENTS WITH METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY. † 843 Pediatric Research. 39: 143-143. DOI: 10.1203/00006450-199604001-00865 |
0.367 |
|
| 1995 |
van der Put NM, Steegers-Theunissen RP, Frosst P, Trijbels FJ, Eskes TK, van den Heuvel LP, Mariman EC, den Heyer M, Rozen R, Blom HJ. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet (London, England). 346: 1070-1. PMID 7564788 DOI: 10.1016/S0140-6736(95)91743-8 |
0.357 |
|
| 1995 |
Rozen R, Ferreira-Rajabi L, Robb L, Colman N. L206W mutation of the cystic fibrosis gene, relatively frequent in French Canadians, is associated with atypical presentations of cystic fibrosis. American Journal of Medical Genetics. 57: 437-9. PMID 7545869 DOI: 10.1002/Ajmg.1320570314 |
0.305 |
|
| 1994 |
Goyette P, Sumner JS, Milos R, Duncan AM, Rosenblatt DS, Matthews RG, Rozen R. Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nature Genetics. 7: 195-200. PMID 7920641 DOI: 10.1038/Ng0694-195 |
0.356 |
|
| 1993 |
John SW, Scriver CR, Laframboise R, Rozen R. In vitro and in vivo correlations for I65T and M1V mutations at the phenylalanine hydroxylase locus. Human Mutation. 1: 147-53. PMID 1301201 DOI: 10.1002/Humu.1380010210 |
0.528 |
|
| 1993 |
John SW, Rozen R, Laframboise R, Laberge C, Scriver CR. Five mutations at the PAH locus account for almost 90% of PKU mutations in French-Canadians from eastern Quebec. Human Mutation. 1: 72-4. PMID 1301193 DOI: 10.1002/Humu.1380010112 |
0.489 |
|
| 1992 |
Osborne L, Santis G, Schwarz M, Klinger K, Dörk T, McIntosh I, Schwartz M, Nunes V, Macek M, Reiss J, Highsmith WE, McMahon R, Novelli G, Malik N, Bürger J, ... ... Rozen R, et al. Incidence and expression of the N1303K mutation of the cystic fibrosis (CFTR) gene Human Genetics. 89: 653-658. PMID 1380943 DOI: 10.1007/Bf00221957 |
0.311 |
|
| 1991 |
John SW, Weitzner G, Rozen R, Scriver CR. A rapid procedure for extracting genomic DNA from leukocytes. Nucleic Acids Research. 19: 408. PMID 2014181 DOI: 10.1093/Nar/19.2.408 |
0.452 |
|
| 1991 |
Mascisch A, Rozen R. Deficient synthesis of MTHFD, a trifunctional folate-dependent enzyme, in the CHO Ade E mutant. Somatic Cell and Molecular Genetics. 17: 391-8. PMID 1887335 DOI: 10.1007/Bf01233064 |
0.318 |
|
| 1986 |
Fox J, Hack AM, Fenton WA, Golbus MS, Winter S, Kalousek F, Rozen R, Brusilow SW, Rosenberg LE. Prenatal diagnosis of ornithine transcarbamylase deficiency with use of DNA polymorphisms. The New England Journal of Medicine. 315: 1205-8. PMID 3762643 DOI: 10.1056/Nejm198611063151907 |
0.348 |
|
| 1986 |
McClead RE, Rozen R, Fox J, Rosenberg L, Menke J, Bickers R, Morrow G. Clinical application of DNA analysis in a family with OTC deficiency American Journal of Medical Genetics. 25: 513-518. PMID 2878615 DOI: 10.1002/Ajmg.1320250313 |
0.311 |
|
| 1986 |
Rozen R, Fox JE, Hack AM, Fenton WA, Horwich AL, Rosenberg LE. DNA analysis for ornithine transcarbamylase deficiency. Journal of Inherited Metabolic Disease. 9: 49-57. PMID 2878115 DOI: 10.1007/Bf01800858 |
0.354 |
|
| 1985 |
Goodyer PR, Rozen R, Scriver CR. A gamma-aminobutyric acid-specific transport mechanism in mammalian kidney. Biochimica Et Biophysica Acta. 818: 45-54. PMID 3925996 DOI: 10.1016/0005-2736(85)90136-1 |
0.451 |
|
| 1985 |
Fox J, Rozen R, Fenton W, Horwich A, Rospnherg LF. 820 ADDITIONAL RESTRICTION FRAGMENT LENGTH POLYMORPHISMS (RFLS)FOR DETECTION OF ORNITHINE TRANSCARBAMYLASE (OTC) DEFICIENCY Pediatric Research. 19: 247A-247A. DOI: 10.1203/00006450-198504000-00850 |
0.336 |
|
| 1983 |
Rozen R, Scriver CR, Mohyuddin F. Hypertaurinuria in the C57BL/6J mouse: altered transport at the renal basolateral membrane. The American Journal of Physiology. 244: F150-5. PMID 6824078 DOI: 10.1152/ajprenal.1983.244.2.F150 |
0.507 |
|
| 1982 |
Rozen R, Scriver CR. Renal transport of taurine adapts to perturbed taurine homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 79: 2101-5. PMID 6952257 DOI: 10.1073/Pnas.79.6.2101 |
0.495 |
|
| 1981 |
Rozen R, Scriver CR. 630 RENAL RESPONSE TO ESSENTIAL AMINO ACID DEPRIVATION: ADAPTATION OF TAURINE (TAU) TRANSPORT Pediatric Research. 15: 545-545. DOI: 10.1203/00006450-198104001-00643 |
0.45 |
|
| 1979 |
Rozen R, Tenenhouse HS, Scriver CR. Taurine transport in renal brush-border-membrane vesicles. The Biochemical Journal. 180: 245-8. PMID 486101 DOI: 10.1042/bj1800245 |
0.374 |
|
| 1977 |
Rozen R, Buhl S, Mohyuddin F, Caillibot V, Scriver CR. Evaluation of metabolic pathway activity in cultured skin fibroblasts and blood leukocytes. Clinica Chimica Acta; International Journal of Clinical Chemistry. 77: 379-86. PMID 872438 DOI: 10.1016/0009-8981(77)90244-3 |
0.411 |
|
| Show low-probability matches. |