Jonathan Powell - Publications

Affiliations: 
Oncology Johns Hopkins University, Baltimore, MD 
Area:
Immunology, Cell Biology

132 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Helms RS, Marin-Gonzalez A, Patel CH, Sun IH, Wen J, Leone RD, Duvall B, Gao RD, Ha T, Tsukamoto T, Slusher BS, Pomerantz JL, Powell JD. SIKs Regulate HDAC7 Stabilization and Cytokine Recall in Late-Stage T Cell Effector Differentiation. Journal of Immunology (Baltimore, Md. : 1950). PMID 37947442 DOI: 10.4049/jimmunol.2300248  0.46
2023 Patel CH, Dong Y, Koleini N, Wang X, Dunkerly-Eyring BL, Wen J, Ranek MJ, Bartle LM, Henderson DB, Sagert JG, Kass DA, Powell JD. TSC2 S1365A mutation potently regulates CD8+T cell function and differentiation improving adoptive cellular cancer therapy. Jci Insight. PMID 37788104 DOI: 10.1172/jci.insight.167829  0.554
2023 Arwood ML, Sun IH, Patel CH, Sun IM, Oh MH, Bettencourt IA, Claiborne MD, Chan-Li Y, Zhao L, Waickman AT, Mavrothalassitis O, Wen J, Aja S, Powell JD. Serendipitous Discovery of T Cell-Produced KLK1b22 as a Regulator of Systemic Metabolism. Immunohorizons. 7: 493-507. PMID 37358498 DOI: 10.4049/immunohorizons.2300016  0.755
2023 Motz KM, Lina IA, Samad I, Murphy MK, Duvvuri M, Davis RJ, Gelbard A, Chung L, Chan-Li Y, Collins S, Powell JD, Elisseeff JH, Horton MR, Hillel AT. Targeting mTOR with a sirolimus-eluting airway stent reduces pro-fibrotic TH17-cells and inhibits laryngotracheal stenosis. Jci Insight. PMID 37159282 DOI: 10.1172/jci.insight.158456  0.447
2023 Xu W, Patel CH, Alt J, Zhao L, Sun IH, Oh MH, Sun IM, Wen J, Blosser RL, Tam AJ, Powell JD. GOT1 constrains T17 cell differentiation, while promoting iT cell differentiation. Nature. 614: E1-E11. PMID 36726001 DOI: 10.1038/s41586-022-05602-3  0.454
2023 Xu W, Patel CH, Zhao L, Sun IH, Oh MH, Sun IM, Helms RS, Wen J, Powell JD. GOT1 regulates CD8 effector and memory T cell generation. Cell Reports. 42: 111987. PMID 36640309 DOI: 10.1016/j.celrep.2022.111987  0.515
2022 Patel CH, Heikamp EB, Xu W, Sun IH, Oh MH, Sun IM, Wen J, Tam AJ, Blosser RL, Powell JD. Cutting Edge: mTORC2 Regulates CD8+ Effector and Memory T Cell Differentiation through Serum and Glucocorticoid Kinase 1. Journal of Immunology (Baltimore, Md. : 1950). 209: 2287-2291. PMID 36469844 DOI: 10.4049/jimmunol.2100669  0.49
2022 Patel CH, Heikamp EB, Xu W, Sun IH, Oh MH, Sun IM, Wen J, Tam AJ, Blosser RL, Powell JD. Cutting Edge: mTORC2 Regulates CD8 Effector and Memory T Cell Differentiation through Serum and Glucocorticoid Kinase 1. Journal of Immunology (Baltimore, Md. : 1950). PMID 36332975 DOI: 10.4049/jimmunol.2100669  0.49
2022 Claiborne MD, Sengupta S, Zhao L, Arwood ML, Sun IM, Wen J, Thompson EA, Mitchell-Flack M, Laiho M, Powell JD. Persistent CAD activity in memory CD8 T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge. Science Immunology. 7: eabh4271. PMID 35622902 DOI: 10.1126/sciimmunol.abh4271  0.503
2021 McCurdy SR, Radojcic V, Tsai HL, Vulic A, Thompson E, Ivcevic S, Kanakry CG, Powell JD, Lohman BK, Adom D, Paczesny S, Cooke KR, Jones RJ, Varadhan R, Symons HJ, et al. Signatures of GVHD and Relapse after Post-Transplant Cyclophosphamide Revealed by Immune Profiling and Machine Learning. Blood. PMID 34657151 DOI: 10.1182/blood.2021013054  0.307
2021 Mo F, Yu Z, Li P, Oh J, Spolski R, Zhao L, Glassman CR, Yamamoto TN, Chen Y, Golebiowski FM, Hermans D, Majri-Morrison S, Picton LK, Liao W, Ren M, ... ... Powell JD, et al. An engineered IL-2 partial agonist promotes CD8 T cell stemness. Nature. PMID 34526724 DOI: 10.1038/s41586-021-03861-0  0.486
2021 Wagle MV, Vervoort SJ, Kelly MJ, Van Der Byl W, Peters TJ, Martin BP, Martelotto LG, Nüssing S, Ramsbottom KM, Torpy JR, Knight D, Reading S, Thia K, Miosge LA, Howard DR, ... ... Powell JD, et al. Antigen-driven EGR2 expression is required for exhausted CD8 T cell stability and maintenance. Nature Communications. 12: 2782. PMID 33986293 DOI: 10.1038/s41467-021-23044-9  0.395
2021 Dykema AG, Zhang B, Woldemeskel BA, Garliss CC, Cheung LS, Choudhury D, Zhang J, Aparicio L, Bom S, Rashid R, Caushi JX, Hsiue EH, Cascino K, Thompson EA, Kwaa AK, ... ... Powell JD, et al. Functional characterization of CD4+ T-cell receptors cross-reactive for SARS-CoV-2 and endemic coronaviruses. The Journal of Clinical Investigation. PMID 33830946 DOI: 10.1172/JCI146922  0.455
2021 Thompson EA, Cascino K, Ordonez AA, Zhou W, Vaghasia A, Hamacher-Brady A, Brady NR, Sun IH, Wang R, Rosenberg AZ, Delannoy M, Rothman R, Fenstermacher K, Sauer L, Shaw-Saliba K, ... ... Powell JD, et al. Metabolic programs define dysfunctional immune responses in severe COVID-19 patients. Cell Reports. 108863. PMID 33691089 DOI: 10.1016/j.celrep.2021.108863  0.367
2021 Leone RD, Powell JD. Fueling the Revolution: Targeting Metabolism to Enhance Immunotherapy. Cancer Immunology Research. 9: 255-260. PMID 33648947 DOI: 10.1158/2326-6066.CIR-20-0791  0.308
2020 Thompson E, Cascino K, Ordonez A, Zhou W, Vaghasia A, Hamacher-Brady A, Brady N, Sun IH, Wang R, Rosenberg A, Delanoy M, Rothman RE, Fenstermacher K, Sauer L, Shaw-Saliba K, ... ... Powell JD, et al. Mitochondrial induced T cell apoptosis and aberrant myeloid metabolic programs define distinct immune cell subsets during acute and recovered SARS-CoV-2 infection. Medrxiv : the Preprint Server For Health Sciences. PMID 32935120 DOI: 10.1101/2020.09.10.20186064  0.332
2020 Cheng CH, Lee CF, Oh BC, Furtmüller GJ, Patel CH, Brandacher G, Powell JD. Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term Immunosuppression. Frontiers in Immunology. 11: 572. PMID 32328063 DOI: 10.3389/fimmu.2020.00572  0.431
2020 Bever KM, Borazanci EH, Thompson E, Wu A, Durham JN, Liu M, Wilt C, Fu W, Leal JP, De Jesus-Acosta A, Wang H, Cosgrove D, Zheng L, Laheru DA, Von Hoff DD, ... ... Powell J, et al. An exploratory study of metformin (Met) with or without rapamycin (Rapa) as maintenance therapy after induction chemotherapy in patients (Pts) with metastatic pancreatic adenocarcinoma (PDA). Journal of Clinical Oncology. 38: 700-700. DOI: 10.1200/Jco.2020.38.4_Suppl.700  0.33
2020 Powell J, Leone R, Oh M, Rais R, Majer P, Slusher B. Abstract IA10: Targeting glutamine metabolism as a means of enhancing immunotherapy for cancer Clinical Cancer Research. 26. DOI: 10.1158/1557-3265.Aacrahns19-Ia10  0.376
2019 Vis B, Hewitt RE, Monie TP, Fairbairn C, Turner SD, Kinrade SD, Powell JJ. Ultrasmall silica nanoparticles directly ligate the T cell receptor complex. Proceedings of the National Academy of Sciences of the United States of America. PMID 31871161 DOI: 10.1073/pnas.1911360117  0.501
2019 Leone RD, Zhao L, Englert JM, Sun IM, Oh MH, Sun IH, Arwood ML, Bettencourt IA, Patel CH, Wen J, Tam A, Blosser RL, Prchalova E, Alt J, Rais R, ... ... Powell JD, et al. Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion. Science (New York, N.Y.). PMID 31699883 DOI: 10.1126/Science.Aav2588  0.319
2019 Patel CH, Leone RD, Horton MR, Powell JD. Targeting metabolism to regulate immune responses in autoimmunity and cancer. Nature Reviews. Drug Discovery. PMID 31363227 DOI: 10.1038/s41573-019-0032-5  0.324
2019 Oh M, Travers M, Brown S, Zhao L, Sun I, Sun I, Arwood M, Xu W, Collins S, Leone R, Prchalova E, Rais R, Slusher B, Horton M, Zahnow C, ... Powell J, et al. Abstract LB-022: Targeting glutamine metabolism as a mean of treating a murine model of ovarian cancer and ascites development Cancer Research. 79. DOI: 10.1158/1538-7445.Am2019-Lb-022  0.407
2019 Leone R, Sun I, Chikarmane R, Viswanathan R, Patwari S, Arwood M, Ghiaur G, Powell J. Abstract 2991: Targeting glutamine metabolism leads to terminal differentiation in acute myeloid leukemia (AML) Cancer Research. 79: 2991-2991. DOI: 10.1158/1538-7445.Am2019-2991  0.377
2018 Xu W, Powell JD. Peeking under the Hood of Naive T Cells. Cell Metabolism. 28: 801-802. PMID 30517891 DOI: 10.1016/j.cmet.2018.11.008  0.498
2018 Vis B, Hewitt RE, Faria N, Bastos C, Chappell H, Pele L, Jugdaohsingh R, Kinrade SD, Powell JJ. Non-Functionalized Ultrasmall Silica Nanoparticles Directly and Size-Selectively Activate T Cells. Acs Nano. PMID 30346692 DOI: 10.1021/Acsnano.8B03363  0.408
2018 Leone RD, Sun IM, Oh MH, Sun IH, Wen J, Englert J, Powell JD. Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models. Cancer Immunology, Immunotherapy : Cii. PMID 29923026 DOI: 10.1007/s00262-018-2186-0  0.478
2018 Sun IH, Oh MH, Zhao L, Patel CH, Arwood ML, Xu W, Tam AJ, Blosser RL, Wen J, Powell JD. mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3 Regulatory T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 29884702 DOI: 10.4049/Jimmunol.1701477  0.534
2018 Walton ZE, Patel CH, Brooks RC, Yu Y, Ibrahim-Hashim A, Riddle M, Porcu A, Jiang T, Ecker BL, Tameire F, Koumenis C, Weeraratna AT, Welsh DK, Gillies R, Alwine JC, ... ... Powell JD, et al. Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR. Cell. PMID 29861175 DOI: 10.1016/J.Cell.2018.05.009  0.302
2018 Powell J, Mota F, Steadman D, Soudy C, Miyauchi JT, Crosby S, Jarvis A, Reisinge T, Winfield N, Evans G, Finniear A, Yelland T, Chou YT, Chan AWE, O'Leary A, et al. Small molecule neuropilin-1 antagonists combine anti-angiogenic and anti-tumour activity with immune modulation through reduction of transforming growth factor beta (TGFβ) production in regulatory T-cells. Journal of Medicinal Chemistry. PMID 29648813 DOI: 10.1021/Acs.Jmedchem.8B00210  0.369
2018 Leone R, Englert J, Sun I, Oh M, Alt J, Sun I, Tam AJ, Majer P, Rais R, Slusher B, Powell J. Abstract 4963: Targeting glutamine metabolism as a means of enhancing antitumor T-cell responses Cancer Research. 78: 4963-4963. DOI: 10.1158/1538-7445.Am2018-4963  0.549
2017 Oh MH, Collins SL, Sun IH, Tam AJ, Patel CH, Arwood ML, Chan-Li Y, Powell JD, Horton MR. mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages. Cell Reports. 20: 2439-2454. PMID 28877476 DOI: 10.1016/J.Celrep.2017.08.046  0.345
2017 Patel CH, Powell JD. Targeting T cell metabolism to regulate T cell activation, differentiation and function in disease. Current Opinion in Immunology. 46: 82-88. PMID 28521236 DOI: 10.1016/j.coi.2017.04.006  0.48
2017 Chornoguz O, Hagan RS, Haile A, Arwood ML, Gamper CJ, Banerjee A, Powell JD. mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation. Journal of Immunology (Baltimore, Md. : 1950). PMID 28424242 DOI: 10.4049/Jimmunol.1601078  0.473
2017 Hewitt RE, Robertson J, Haas CT, Pele LC, Powell JJ. Reduction of T-Helper Cell Responses to Recall Antigen Mediated by Codelivery with Peptidoglycan via the Intestinal Nanomineral-Antigen Pathway. Frontiers in Immunology. 8: 284. PMID 28367148 DOI: 10.3389/fimmu.2017.00284  0.415
2017 Williams JB, Horton BL, Zheng Y, Duan Y, Powell JD, Gajewski TF. The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment. The Journal of Experimental Medicine. PMID 28115575 DOI: 10.1084/jem.20160485  0.424
2016 Vigeland CL, Collins SL, Chan-Li Y, Hughes AH, Oh MH, Powell JD, Horton MR. Deletion of mTORC1 Activity in CD4+ T Cells Is Associated with Lung Fibrosis and Increased γδ T Cells. Plos One. 11: e0163288. PMID 27649073 DOI: 10.1371/journal.pone.0163288  0.374
2016 Ladle BH, Li KP, Phillips MJ, Pucsek AB, Haile A, Powell JD, Jaffee EM, Hildeman DA, Gamper CJ. De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27582468 DOI: 10.1073/Pnas.1524490113  0.499
2016 Hsiao PY, Kalin J, Sun IH, Amin M, Lo YC, Chiang MJ, Giddens J, Sysa-Shah P, Gabrielson K, Wang LX, Powell J, Cole PA. An Fc-Small Molecule Conjugate for Targeted Inhibition of the Adenosine 2A Receptor. Chembiochem : a European Journal of Chemical Biology. PMID 27432157 DOI: 10.1002/Cbic.201600337  0.699
2016 Ananieva EA, Powell JD, Hutson SM. Leucine Metabolism in T Cell Activation: mTOR Signaling and Beyond. Advances in Nutrition (Bethesda, Md.). 7: 798S-805S. PMID 27422517 DOI: 10.3945/An.115.011221  0.527
2016 Collins SL, Chan-Li Y, Oh M, Vigeland CL, Limjunyawong N, Mitzner W, Powell JD, Horton MR. Vaccinia vaccine-based immunotherapy arrests and reverses established pulmonary fibrosis. Jci Insight. 1: e83116. PMID 27158671 DOI: 10.1172/Jci.Insight.83116  0.308
2016 Pollizzi KN, Sun IH, Patel CH, Lo YC, Oh MH, Waickman AT, Tam AJ, Blosser RL, Wen J, Delgoffe GM, Powell JD. Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation. Nature Immunology. PMID 27064374 DOI: 10.1038/Ni.3438  0.833
2016 Willingham S, Ho P, Leone R, Piccione E, Choy C, Hotson A, Buggy J, Powell J, Miller R. Abstract 2337: The adenosine A2A receptor antagonist CPI-444 blocks adenosine-mediated T-cell suppression and exhibits antitumor activity alone and in combination with anti-PD-1 and anti-PD-L1 Cancer Research. 76: 2337-2337. DOI: 10.1158/1538-7445.Am2016-2337  0.366
2016 Gross M, Chen J, Englert J, Janes J, Leone R, MacKinnon A, Parlati F, Rodriquez M, Shwonek P, Powell J. Abstract 2329: Glutaminase inhibition with CB-839 enhances anti-tumor activity of PD-1 and PD-L1 antibodies by overcoming a metabolic checkpoint blocking T cell activation Cancer Research. 76: 2329-2329. DOI: 10.1158/1538-7445.Am2016-2329  0.499
2016 Englert J, Cheng C, Leone R, Majer P, Rais R, Slusher B, Powell J. Abstract 1035: Targeting glutamine metabolism with the novel inhibitor JHU-083 inhibits tumor growth and alters the tumor immune microenvironment Cancer Research. 76: 1035-1035. DOI: 10.1158/1538-7445.Am2016-1035  0.406
2016 Vigeland C, Chan-li Y, Collins S, Hughes A, Oh M, Powell J, Horton M. P104 Targeting glutamine metabolism as a novel mechanism of arresting pulmonary fibrosis Qjm: An International Journal of Medicine. 109. DOI: 10.1093/Qjmed/Hcw120.005  0.38
2016 Willingham S, Ho P, Leone R, Choy C, Powell J, McCaffery I, Miller R. Adenosine A2A receptor antagonist, CPI-444, blocks adenosine-mediated T cell suppression and exhibits anti-tumor activity alone and in combination with anti-PD-1 and anti-PD-L1 Annals of Oncology. 27: vi366. DOI: 10.1093/Annonc/Mdw378.22  0.338
2015 Sharma MD, Shinde R, McGaha TL, Huang L, Holmgaard RB, Wolchok JD, Mautino MR, Celis E, Sharpe AH, Francisco LM, Powell JD, Yagita H, Mellor AL, Blazar BR, Munn DH. The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Science Advances. 1: e1500845. PMID 26601142 DOI: 10.1126/Sciadv.1500845  0.346
2015 Lee CF, Lo YC, Cheng CH, Furtmüller GJ, Oh B, Andrade-Oliveira V, Thomas AG, Bowman CE, Slusher BS, Wolfgang MJ, Brandacher G, Powell JD. Preventing Allograft Rejection by Targeting Immune Metabolism. Cell Reports. PMID 26489460 DOI: 10.1016/j.celrep.2015.09.036  0.769
2015 Gordon EB, Hart GT, Tran TM, Waisberg M, Akkaya M, Kim AS, Hamilton SE, Pena M, Yazew T, Qi CF, Lee CF, Lo YC, Miller LH, Powell JD, Pierce SK. Targeting glutamine metabolism rescues mice from late-stage cerebral malaria. Proceedings of the National Academy of Sciences of the United States of America. PMID 26438846 DOI: 10.1073/Pnas.1516544112  0.67
2015 Delgoffe GM, Powell JD. Feeding an army: The metabolism of T cells in activation, anergy, and exhaustion. Molecular Immunology. PMID 26256793 DOI: 10.1016/J.Molimm.2015.07.026  0.749
2015 Noonan KA, Huff CA, Davis J, Lemas MV, Fiorino S, Bitzan J, Ferguson A, Emerling A, Luznik L, Matsui W, Powell J, Fuchs E, Rosner GL, Epstein C, Rudraraju L, et al. Adoptive transfer of activated marrow-infiltrating lymphocytes induces measurable antitumor immunity in the bone marrow in multiple myeloma. Science Translational Medicine. 7: 288ra78. PMID 25995224 DOI: 10.1126/Scitranslmed.Aaa7014  0.444
2015 Leone RD, Lo YC, Powell JD. A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy. Computational and Structural Biotechnology Journal. 13: 265-72. PMID 25941561 DOI: 10.1016/j.csbj.2015.03.008  0.685
2015 Pollizzi KN, Patel CH, Sun IH, Oh MH, Waickman AT, Wen J, Delgoffe GM, Powell JD. mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation. The Journal of Clinical Investigation. 125: 2090-108. PMID 25893604 DOI: 10.1172/Jci77746  0.839
2015 Pollizzi KN, Waickman AT, Patel CH, Sun IH, Powell JD. Cellular size as a means of tracking mTOR activity and cell fate of CD4+ T cells upon antigen recognition. Plos One. 10: e0121710. PMID 25849206 DOI: 10.1371/Journal.Pone.0121710  0.858
2015 Delgoffe GM, Powell JD. Sugar, fat, and protein: new insights into what T cells crave. Current Opinion in Immunology. 33: 49-54. PMID 25665466 DOI: 10.1016/J.Coi.2015.01.015  0.74
2015 Pollizzi KN, Powell JD. Regulation of T cells by mTOR: the known knowns and the known unknowns. Trends in Immunology. 36: 13-20. PMID 25522665 DOI: 10.1016/J.It.2014.11.005  0.83
2015 Prevot N, Pyaram K, Bischoff E, Sen JM, Powell JD, Chang CH. Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger. Journal of Immunology (Baltimore, Md. : 1950). 194: 223-30. PMID 25404366 DOI: 10.4049/jimmunol.1401985  0.41
2015 Sharma M, Shinde R, McGaha T, Huang L, Holmgaard R, Wolchok J, Mautino M, Celis E, Sharpe A, Francisco L, Powell J, Yagita H, Mellor A, Blazar B, Munn D. The PTEN pathway in Tregs functions as a critical driver of the immunosuppressive tumor microenvironment and tolerance to apoptotic cells Journal For Immunotherapy of Cancer. 3: O19. DOI: 10.1186/2051-1426-3-S2-O19  0.46
2015 Delgoffe GM, Powell JD. Feeding an army: The metabolism of T cells in activation, anergy, and exhaustion Molecular Immunology. DOI: 10.1016/j.molimm.2015.07.026  0.715
2014 Kim JS, Sklarz T, Banks LB, Gohil M, Waickman AT, Skuli N, Krock BL, Luo CT, Hu W, Pollizzi KN, Li MO, Rathmell JC, Birnbaum MJ, Powell JD, Jordan MS, et al. Retraction: Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways Nature Immunology. 15: 996-996. PMID 25232822 DOI: 10.1038/Ni0910-996  0.701
2014 Lo YC, Lee CF, Powell JD. Insight into the role of mTOR and metabolism in T cells reveals new potential approaches to preventing graft rejection Current Opinion in Organ Transplantation. 19: 363-371. PMID 24991977 DOI: 10.1097/MOT.0000000000000098  0.716
2014 Pollizzi KN, Powell JD. Integrating canonical and metabolic signalling programmes in the regulation of T cell responses Nature Reviews Immunology. 14: 435-446. PMID 24962260 DOI: 10.1038/Nri3701  0.836
2014 Ananieva EA, Patel CH, Drake CH, Powell JD, Hutson SM. Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4+ T cells. The Journal of Biological Chemistry. 289: 18793-804. PMID 24847056 DOI: 10.1074/Jbc.M114.554113  0.567
2014 Heikamp EB, Patel CH, Collins S, Waickman A, Oh MH, Sun IH, Illei P, Sharma A, Naray-Fejes-Toth A, Fejes-Toth G, Misra-Sen J, Horton MR, Powell JD. The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex. Nature Immunology. 15: 457-64. PMID 24705297 DOI: 10.1038/Ni.2867  0.74
2014 Chiang MJ, Holbert MA, Kalin JH, Ahn YH, Giddens J, Amin MN, Taylor MS, Collins SL, Chan-Li Y, Waickman A, Hsiao PY, Bolduc D, Leahy DJ, Horton MR, Wang LX, ... Powell JD, et al. An Fc domain protein-small molecule conjugate as an enhanced immunomodulator. Journal of the American Chemical Society. 136: 3370-3. PMID 24533830 DOI: 10.1021/Ja5006674  0.631
2014 Parkinson RM, Collins SL, Horton MR, Powell JD. Egr3 induces a Th17 response by promoting the development of γδ T cells. Plos One. 9: e87265. PMID 24475259 DOI: 10.1371/Journal.Pone.0087265  0.828
2014 Chiu YL, Shan L, Huang H, Haupt C, Bessell C, Canaday DH, Zhang H, Ho YC, Powell JD, Oelke M, Margolick JB, Blankson JN, Griffin DE, Schneck JP. Sprouty-2 regulates HIV-specific T cell polyfunctionality. The Journal of Clinical Investigation. 124: 198-208. PMID 24292711 DOI: 10.1172/Jci70510  0.488
2014 Lee C, Lo Y, Powell J. Inhibition of T Cell Metabolism as a Novel Means of Preventing Graft Rejection and Promoting Long Term Tolerance. Transplantation. 98: 391-392. DOI: 10.1097/00007890-201407151-01284  0.749
2013 Powell JD, Heikamp EB, Pollizzi KN, Waickman AT. A modified model of T-cell differentiation based on mTOR activity and metabolism Cold Spring Harbor Symposia On Quantitative Biology. 78: 125-130. PMID 24100582 DOI: 10.1101/Sqb.2013.78.020214  0.854
2013 Lo YC, Edidin MA, Powell JD. Selective activation of antigen-experienced T cells by anti-CD3 constrained on nanoparticles Journal of Immunology. 191: 5107-5114. PMID 24098054 DOI: 10.4049/Jimmunol.1301433  0.748
2013 Kim JS, Sklarz T, Banks LB, Gohil M, Waickman AT, Skuli N, Krock BL, Luo CT, Hu W, Pollizzi KN, Li MO, Rathmell JC, Birnbaum MJ, Powell JD, Jordan MS, et al. Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nature Immunology. 14: 611-8. PMID 23644504 DOI: 10.1038/Ni.2607  0.834
2013 Powell JD. Slc7a5 helps T cells get with the program Nature Immunology. 14: 422-424. PMID 23598390 DOI: 10.1038/ni.2594  0.371
2013 Aggarwal NR, D'Alessio FR, Eto Y, Chau E, Avalos C, Waickman AT, Garibaldi BT, Mock JR, Files DC, Sidhaye V, Polotsky VY, Powell J, Horton M, King LS. Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury American Journal of Respiratory Cell and Molecular Biology. 48: 635-645. PMID 23349051 DOI: 10.1165/Rcmb.2012-0351Oc  0.638
2013 Rajeshkumar NV, Yabuuchi S, Patel C, Pai SG, Le DT, Hoff DDV, Dang CV, Maitra A, Powell J. Abstract 5396: Targeting multiple components of the mammalian target of rapamycin (mTOR) signaling: A novel combination therapy to improve pancreatic cancer treatment. Cancer Research. 73: 5396-5396. DOI: 10.1158/1538-7445.Am2013-5396  0.31
2012 Heikamp EB, Powell JD. Sensing the immune microenvironment to coordinate T cell metabolism, differentiation & function Seminars in Immunology. 24: 414-420. PMID 23332779 DOI: 10.1016/j.smim.2012.12.003  0.488
2012 Collins S, Waickman A, Basson A, Kupfer A, Licht JD, Horton MR, Powell JD. Regulation of CD4+ and CD8+ Effector Responses by Sprouty-1 Plos One. 7. PMID 23166773 DOI: 10.1371/Journal.Pone.0049801  0.777
2012 Gamper CJ, Powell JD. All PI3Kinase signaling is not mTOR: dissecting mTOR-dependent and independent signaling pathways in T cells. Frontiers in Immunology. 3: 312. PMID 23087689 DOI: 10.3389/fimmu.2012.00312  0.538
2012 Waickman AT, Powell JD. mTOR, metabolism, and the regulation of T-cell differentiation and function Immunological Reviews. 249: 43-58. PMID 22889214 DOI: 10.1111/J.1600-065X.2012.01152.X  0.785
2012 Thomas RM, Gamper CJ, Ladle BH, Powell JD, Wells AD. De novo DNA methylation is required to restrict T helper lineage plasticity. The Journal of Biological Chemistry. 287: 22900-9. PMID 22584578 DOI: 10.1074/Jbc.M111.312785  0.355
2012 Waickman AT, Powell JD. Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells Journal of Immunology. 188: 4721-4729. PMID 22556133 DOI: 10.4049/Jimmunol.1103143  0.726
2012 Powell JD, Pollizzi K. Fueling memories. Immunity. 36: 3-5. PMID 22284413 DOI: 10.1016/j.immuni.2012.01.003  0.771
2012 Powell JD, Pollizzi KN, Heikamp EB, Horton MR. Regulation of immune responses by mTOR Annual Review of Immunology. 30: 39-68. PMID 22136167 DOI: 10.1146/Annurev-Immunol-020711-075024  0.784
2012 Delgoffe GM, Powell JD. Exploring functional in vivo consequences of the selective genetic ablation of mTOR signaling in T helper lymphocytes Methods in Molecular Biology. 821: 317-327. PMID 22125075 DOI: 10.1007/978-1-61779-430-8_20  0.758
2012 Waickman AT, Alme A, Senaldi L, Zarek PE, Horton M, Powell JD. Enhancement of tumor immunotherapy by deletion of the A 2A adenosine receptor Cancer Immunology, Immunotherapy. 61: 917-926. PMID 22116345 DOI: 10.1007/S00262-011-1155-7  0.766
2012 Gamper CJ, Powell JD. All PI3Kinase signaling is not mTOR: Dissecting mtor-dependent and independent signaling pathways in T cells Frontiers in Immunology. 3. DOI: 10.3389/fimmu.2012.00312  0.361
2012 Kim JS, Sklarz T, Waickman A, Li MO, Rathmell J, Birnbaum M, Powell J, Jordan MS, Koretzky GA. Akt and mTOR Pathways Differentially Regulate the Development of Natural and Inducible IL-17-Producing CD4+ T Cells Blood. 120: 838-838. DOI: 10.1182/Blood.V120.21.838.838  0.777
2012 Powell JD, Pollizzi K. Fueling Memories Immunity. 36: 3-5. DOI: 10.1016/j.immuni.2012.01.003  0.706
2011 Loeb DM, DeLorenzo KA, Chen AR, Meyer CF, Powell J. A dose-finding study of temsirolimus and liposomal doxorubicin for patients with advanced soft tissue or bone sarcoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 10026. PMID 28021104 DOI: 10.1200/Jco.2011.29.15_Suppl.10026  0.306
2011 Michalek RD, Gerriets VA, Nichols AG, Inoue M, Kazmin D, Chang CY, Dwyer MA, Nelson ER, Pollizzi KN, Ilkayeva O, Giguere V, Zuercher WJ, Powell JD, Shinohara ML, McDonnell DP, et al. Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 108: 18348-53. PMID 22042850 DOI: 10.1073/Pnas.1108856108  0.831
2011 Gladstone DE, Bolaños-Meade J, Huff CA, Zahurak M, Flinn I, Borrello I, Luznik L, Fuchs E, Kasamon Y, Matsui W, Powell J, Levitsky H, Brodsky RA, Ambinder R, Jones RJ, et al. High-dose cyclophosphamide and rituximab without stem cell transplant: a feasibility study for low grade B-cell, transformed and mantle cell lymphomas. Leukemia & Lymphoma. 52: 2076-81. PMID 21756035 DOI: 10.3109/10428194.2011.594191  0.321
2011 Li Q, Rao RR, Araki K, Pollizzi K, Odunsi K, Powell JD, Shrikant PA. A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity. Immunity. 34: 541-53. PMID 21511183 DOI: 10.1016/J.Immuni.2011.04.006  0.813
2011 Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, Horton MR, Xiao B, Worley PF, Powell JD. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nature Immunology. 12: 295-303. PMID 21358638 DOI: 10.1038/Ni.2005  0.837
2011 Noonan K, Huff CA, Sproul JMD, Lemas MVM, Rudraraju L, Luznik L, Powell J, Bolaños-Meade J, Bitzan J, Fiorino S, Matsui W, Jones RJ, Borrello IM. Phase I/II Study of Marrow Infiltrating Lymphocytes (MILs) Generates Measurable Myeloma-Specific Immunity in the Autologous Stem Cell Transplant (SCT) Setting Blood. 118: 997-997. DOI: 10.1182/Blood.V118.21.997.997  0.461
2010 Powell JD, Delgoffe GM. The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism. Immunity. 33: 301-11. PMID 20870173 DOI: 10.1016/J.Immuni.2010.09.002  0.774
2010 Akbulut S, Reddi AL, Aggarwal P, Ambardekar C, Canciani B, Kim MK, Hix L, Vilimas T, Mason J, Basson MA, Lovatt M, Powell J, Collins S, Quatela S, Phillips M, et al. Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C. Molecular Biology of the Cell. 21: 3487-96. PMID 20719962 DOI: 10.1091/Mbc.E10-02-0123  0.484
2010 Remondini D, Salvioli S, Francesconi M, Pierini M, Mazzatti DJ, Powell JR, Zironi I, Bersani F, Castellani G, Franceschi C. Complex patterns of gene expression in human T cells during in vivo aging. Molecular Biosystems. 6: 1983-92. PMID 20686723 DOI: 10.1039/c004635c  0.38
2010 Horton MR, Powell JD. Quieting T cells with Slfn2. Nature Immunology. 11: 281-2. PMID 20300134 DOI: 10.1038/ni0410-281  0.492
2010 Gamper CJ, Powell JD. Genetic and biochemical regulation of CD4 T cell effector differentiation: insights from examination of T cell clonal anergy. Immunologic Research. 47: 162-71. PMID 20077160 DOI: 10.1007/s12026-009-8147-0  0.499
2010 Gulen MF, Kang Z, Bulek K, Youzhong W, Kim TW, Chen Y, Altuntas CZ, Sass Bak-Jensen K, McGeachy MJ, Do JS, Xiao H, Delgoffe GM, Min B, Powell JD, Tuohy VK, et al. The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity. 32: 54-66. PMID 20060329 DOI: 10.1016/J.Immuni.2009.12.003  0.684
2010 Gulen MF, Kang Z, Bulek K, Youzhong W, Kim TW, Chen Y, Altuntas CZ, Bak-Jensen KS, McGeachy MJ, Do J, Xiao H, Delgoffe GM, Min B, Powell JD, Tuohy VK, et al. SS1-2 SIGIRR protein suppresses Th17 cell proliferation via negative regulation of the Interleukin-1 receptor pathway and inhibition of mTOR kinase activation Cytokine. 52: 11. DOI: 10.1016/J.Cyto.2010.07.049  0.649
2009 Zheng Y, Delgoffe GM, Meyer CF, Chan W, Powell JD. Anergic T cells are metabolically anergic. Journal of Immunology (Baltimore, Md. : 1950). 183: 6095-101. PMID 19841171 DOI: 10.4049/Jimmunol.0803510  0.758
2009 Fishman P, Bar-Yehuda S, Synowitz M, Powell JD, Klotz KN, Gessi S, Borea PA. Adenosine receptors and cancer. Handbook of Experimental Pharmacology. 399-441. PMID 19639290 DOI: 10.1007/978-3-540-89615-9_14  0.3
2009 Gamper CJ, Agoston AT, Nelson WG, Powell JD. Identification of DNA methyltransferase 3a as a T cell receptor-induced regulator of Th1 and Th2 differentiation. Journal of Immunology (Baltimore, Md. : 1950). 183: 2267-76. PMID 19625655 DOI: 10.4049/jimmunol.0802960  0.474
2009 Delgoffe GM, Powell JD. mTOR: taking cues from the immune microenvironment. Immunology. 127: 459-65. PMID 19604300 DOI: 10.1111/J.1365-2567.2009.03125.X  0.747
2009 Delgoffe GM, Kole TP, Cotter RJ, Powell JD. Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation. Molecular Immunology. 46: 2694-8. PMID 19586661 DOI: 10.1182/Blood.V112.11.674.674  0.755
2009 Delgoffe GM, Kole TP, Zheng Y, Zarek PE, Matthews KL, Xiao B, Worley PF, Kozma SC, Powell JD. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity. 30: 832-44. PMID 19538929 DOI: 10.1016/J.Immuni.2009.04.014  0.853
2009 Scheibner KA, Boodoo S, Collins S, Black KE, Chan-Li Y, Zarek P, Powell JD, Horton MR. The adenosine a2a receptor inhibits matrix-induced inflammation in a novel fashion. American Journal of Respiratory Cell and Molecular Biology. 40: 251-9. PMID 18703794 DOI: 10.1165/Rcmb.2008-0168Oc  0.764
2008 Huang GN, Huso DL, Bouyain S, Tu J, McCorkell KA, May MJ, Zhu Y, Lutz M, Collins S, Dehoff M, Kang S, Whartenby K, Powell J, Leahy D, Worley PF. NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science (New York, N.Y.). 319: 476-81. PMID 18218901 DOI: 10.1126/Science.1151227  0.613
2008 Collins S, Lutz MA, Zarek PE, Anders RA, Kersh GJ, Powell JD. Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3. European Journal of Immunology. 38: 528-36. PMID 18203138 DOI: 10.1002/Eji.200737157  0.854
2008 Zarek PE, Huang CT, Lutz ER, Kowalski J, Horton MR, Linden J, Drake CG, Powell JD. A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells. Blood. 111: 251-9. PMID 17909080 DOI: 10.1182/Blood-2007-03-081646  0.826
2008 Delgoffe GM, Kole TP, Zheng Y, Xiao B, Worley PF, Kozma SC, Powell J. TOR Complex 1 and TOR Complex 2 Differentially Regulate Effector and Regulatory T Cell Differentiation Blood. 112: 675-675. DOI: 10.1182/Blood.V112.11.675.675  0.789
2007 Zarek PE, Powell JD. Adenosine and anergy. Autoimmunity. 40: 425-32. PMID 17729036 DOI: 10.1080/08916930701464939  0.846
2007 Mazzatti DJ, Pawelec G, Longdin R, Powell JR, Forsey RJ. SELDI-TOF-MS ProteinChip array profiling of T-cell clones propagated in long-term culture identifies human profilin-1 as a potential bio-marker of immunosenescence. Proteome Science. 5: 7. PMID 17550585 DOI: 10.1186/1477-5956-5-7  0.437
2007 Durakovic N, Radojcic V, Powell J, Luznik L. Rapamycin promotes emergence of IL-10-secreting donor lymphocyte infusion-derived T cells without compromising their graft-versus-leukemia reactivity. Transplantation. 83: 631-40. PMID 17353785 DOI: 10.1097/01.Tp.0000256158.84418.Ff  0.508
2007 Mazzatti DJ, White A, Forsey RJ, Powell JR, Pawelec G. Gene expression changes in long-term culture of T-cell clones: genomic effects of chronic antigenic stress in aging and immunosenescence. Aging Cell. 6: 155-63. PMID 17286612 DOI: 10.1111/j.1474-9726.2007.00269.x  0.422
2007 Zheng Y, Collins SL, Lutz MA, Allen AN, Kole TP, Zarek PE, Powell JD. A role for mammalian target of rapamycin in regulating T cell activation versus anergy. Journal of Immunology (Baltimore, Md. : 1950). 178: 2163-70. PMID 17277121 DOI: 10.4049/Jimmunol.178.4.2163  0.843
2006 Collins S, Wolfraim LA, Drake CG, Horton MR, Powell JD. Cutting Edge: TCR-induced NAB2 enhances T cell function by coactivating IL-2 transcription. Journal of Immunology (Baltimore, Md. : 1950). 177: 8301-5. PMID 17142725  0.374
2006 Powell JD, Zheng Y. Dissecting the mechanism of T-cell anergy with immunophilin ligands. Current Opinion in Investigational Drugs (London, England : 2000). 7: 1002-7. PMID 17117589  0.504
2006 Powell JD. The induction and maintenance of T cell anergy. Clinical Immunology (Orlando, Fla.). 120: 239-46. PMID 16581297 DOI: 10.1016/j.clim.2006.02.004  0.523
2005 Powell JD, Horton MR. Threat matrix: low-molecular-weight hyaluronan (HA) as a danger signal. Immunologic Research. 31: 207-18. PMID 15888912 DOI: 10.1385/IR:31:3:207  0.401
2005 Safford M, Collins S, Lutz MA, Allen A, Huang CT, Kowalski J, Blackford A, Horton MR, Drake C, Schwartz RH, Powell JD. Egr-2 and Egr-3 are negative regulators of T cell activation. Nature Immunology. 6: 472-80. PMID 15834410 DOI: 10.1038/ni1193  0.528
2005 Safford M, Collins S, Lutz MA, Allen A, Huang C, Kowalski J, Blackford A, Horton MR, Drake C, Schwartz RH, Powell JD. Erratum: Egr-2 and Egr-3 are negative regulators of T cell activation Nature Immunology. 6: 737-737. DOI: 10.1038/NI0705-737  0.497
2004 Huang CT, Workman CJ, Flies D, Pan X, Marson AL, Zhou G, Hipkiss EL, Ravi S, Kowalski J, Levitsky HI, Powell JD, Pardoll DM, Drake CG, Vignali DA. Role of LAG-3 in regulatory T cells. Immunity. 21: 503-13. PMID 15485628 DOI: 10.1016/J.Immuni.2004.08.010  0.478
2004 Allen A, Zheng Y, Gardner L, Safford M, Horton MR, Powell JD. The novel cyclophilin binding compound, sanglifehrin A, disassociates G1 cell cycle arrest from tolerance induction. Journal of Immunology (Baltimore, Md. : 1950). 172: 4797-803. PMID 15067056 DOI: 10.4049/jimmunol.172.8.4797  0.395
2004 Kowalski J, Drake C, Schwartz RH, Powell J. Non-parametric, hypothesis-based analysis of microarrays for comparison of several phenotypes. Bioinformatics (Oxford, England). 20: 364-73. PMID 14960463 DOI: 10.1093/Bioinformatics/Btg418  0.339
2003 Shin T, Kennedy G, Gorski K, Tsuchiya H, Koseki H, Azuma M, Yagita H, Chen L, Powell J, Pardoll D, Housseau F. Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor. The Journal of Experimental Medicine. 198: 31-8. PMID 12847135 DOI: 10.1084/Jem.20030242  0.426
1993 Powell JD, Bednarik DP, Folks TM, Jehuda-Cohen T, Villinger F, Sell KW, Ansari AA. Inhibition of cellular activation of retroviral replication by CD8+ T cells derived from non-human primates. Clinical and Experimental Immunology. 91: 473-81. PMID 8383022 DOI: 10.1111/J.1365-2249.1993.Tb05927.X  0.438
1992 Powell JD, Bednarik DP, Jehuda-Cohen T, Villinger F, Folks TM, Ansari AA. Regulation of immune activation/retroviral replication by CD8+ T cells. Annals of the New York Academy of Sciences. 636: 360-2. PMID 1665323 DOI: 10.1111/J.1749-6632.1991.Tb33466.X  0.454
1990 Ahmed-Ansari A, Powell JD, Jensen PE, Yehuda-Cohen T, McClure HM, Anderson D, Fultz PN, Sell KW. Requirements for simian immunodeficiency virus antigen-specific in vitro proliferation of T cells from infected rhesus macaques and sooty mangabeys Aids. 4: 399-407. PMID 2164818 DOI: 10.1097/00002030-199005000-00004  0.351
1990 Yehuda‐Cohen T, Powell JD, Villinger F, McClure HM, Sell KW, Ahmed‐Ansari A. Comparison of SIV/SMM Replication in CD4 + T Cell and Monocyte/Macrophage Cultures From Rhesus Macaques and Sooty Mangabeys Journal of Medical Primatology. 19: 251-267. DOI: 10.1111/j.1600-0684.1990.tb00432.x  0.35
1989 Powell J, Stone J, Chan WC, Yang ZD, Leatherbury A, Sell KW, Wiktor-Jedrzejczak W, Ahmed-Ansari A. Interferon-gamma-treated K562 target cells distinguish functional NK cells from lymphokine-activated killer (LAK) cells. Cellular Immunology. 118: 250-64. PMID 2491960 DOI: 10.1016/0008-8749(89)90376-6  0.424
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