| Year |
Citation |
Score |
| 2020 |
Carofiglio F, Trisciuzzi D, Gambacorta N, Leonetti F, Stefanachi A, Nicolotti O. Bcr-Abl Allosteric Inhibitors: Where We Are and Where We Are Going to. Molecules (Basel, Switzerland). 25. PMID 32937901 DOI: 10.3390/Molecules25184210 |
0.332 |
|
| 2020 |
Spinelli F, Giampietro R, Stefanachi A, Riganti C, Kopecka J, Abatematteo FS, Leonetti F, Colabufo NA, Mangiatordi GF, Nicolotti O, Perrone MG, Brea J, Loza MI, Infantino V, Abate C, et al. Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R). European Journal of Medicinal Chemistry. 188: 112037. PMID 31954990 DOI: 10.1016/J.Ejmech.2020.112037 |
0.324 |
|
| 2019 |
Leopoldo M, Nardulli P, Contino M, Leonetti F, Luurtsema G, Colabufo NA. An updated patent review on P-glycoprotein inhibitors (2011-2018). Expert Opinion On Therapeutic Patents. PMID 31079547 DOI: 10.1080/13543776.2019.1618273 |
0.311 |
|
| 2018 |
Riganti C, Contino M, Guglielmo S, Perrone MG, Salaroglio IC, Milosevic V, Giampietro R, Leonetti F, Rolando B, Lazzarato L, Colabufo NA, Fruttero R. Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. Journal of Medicinal Chemistry. PMID 30584838 DOI: 10.1021/Acs.Jmedchem.8B01655 |
0.353 |
|
| 2018 |
Mangiatordi GF, Trisciuzzi D, Iacobazzi R, Denora N, Pisani L, Catto M, Leonetti F, Alberga D, Nicolotti O. Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors. Chemical Biology & Drug Design. PMID 29633572 DOI: 10.1111/Cbdd.13200 |
0.34 |
|
| 2018 |
Stefanachi A, Leonetti F, Pisani L, Catto M, Carotti A. Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds. Molecules (Basel, Switzerland). 23. PMID 29382051 DOI: 10.3390/Molecules23020250 |
0.35 |
|
| 2017 |
Altomare CD, Majellaro M, Stefanachi A, Tardia P, Vicenti C, Boccarelli A, Pannunzio A, Campanella F, Coluccia M, Denora N, Leonetti F, de Candia M, Cellamare S. Investigating structural requirements for the antiproliferative activity of biphenyl nicotinamides. Chemmedchem. PMID 28665505 DOI: 10.1002/Cmdc.201700365 |
0.358 |
|
| 2016 |
Stefanachi A, Mangiatordi GF, Tardia P, Alberga D, Leonetti F, Niso M, Colabufo NA, Adamo C, Nicolotti O, Cellamare S. Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness. Chemical Biology & Drug Design. PMID 27331911 DOI: 10.1111/Cbdd.12811 |
0.387 |
|
| 2015 |
Pau A, Catto M, Pinna G, Frau S, Murineddu G, Asproni B, Curzu MM, Pisani L, Leonetti F, Loza MI, Brea J, Pinna GA, Carotti A. Multitarget-directed tricyclic pyridazinones as G protein-coupled receptor ligands and cholinesterase inhibitors. Chemmedchem. 10: 1054-70. PMID 25924828 DOI: 10.1002/Cmdc.201500124 |
0.326 |
|
| 2015 |
Stefanachi A, Hanke N, Pisani L, Leonetti F, Nicolotti O, Catto M, Cellamare S, Hartmann RW, Carotti A. Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase. European Journal of Medicinal Chemistry. 89: 106-14. PMID 25462231 DOI: 10.1016/J.Ejmech.2014.10.021 |
0.362 |
|
| 2014 |
Tardia P, Stefanachi A, Niso M, Stolfa DA, Mangiatordi GF, Alberga D, Nicolotti O, Lattanzi G, Carotti A, Leonetti F, Perrone R, Berardi F, Azzariti A, Colabufo NA, Cellamare S. Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding. Journal of Medicinal Chemistry. 57: 6403-18. PMID 25093931 DOI: 10.1021/Jm500697C |
0.33 |
|
| 2013 |
Favia AD, Nicolotti O, Stefanachi A, Leonetti F, Carotti A. Computational methods for the design of potent aromatase inhibitors Expert Opinion On Drug Discovery. 8: 395-409. PMID 23373669 DOI: 10.1517/17460441.2013.768983 |
0.311 |
|
| 2013 |
Catto M, Pisani L, Leonetti F, Nicolotti O, Pesce P, Stefanachi A, Cellamare S, Carotti A. Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase. Bioorganic & Medicinal Chemistry. 21: 146-52. PMID 23199476 DOI: 10.1016/J.Bmc.2012.10.045 |
0.388 |
|
| 2012 |
Nicolotti O, Catto M, Giangreco I, Barletta M, Leonetti F, Stefanachi A, Pisani L, Cellamare S, Tortorella P, Loiodice F, Carotti A. Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9. European Journal of Medicinal Chemistry. 58: 368-76. PMID 23149299 DOI: 10.1016/J.Ejmech.2012.09.036 |
0.318 |
|
| 2012 |
Pellicani RZ, Stefanachi A, Niso M, Carotti A, Leonetti F, Nicolotti O, Perrone R, Berardi F, Cellamare S, Colabufo NA. Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. Journal of Medicinal Chemistry. 55: 424-36. PMID 22112208 DOI: 10.1021/Jm201305Y |
0.351 |
|
| 2012 |
Leonetti F, Muncipinto G, Stefanachi A, Nicolotti O, Cellamare S, Catto M, Pisani L, Pellegrino G, Carotti A. Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams Tetrahedron Letters. 53: 4114-4116. DOI: 10.1016/J.Tetlet.2012.05.124 |
0.376 |
|
| 2011 |
Nicolotti O, Pisani L, Catto M, Leonetti F, Giangreco I, Stefanachi A, Carotti A. Discovery of a Potent and Selective Hetero-Bivalent AChE Inhibitor via Bioisosteric Replacement. Molecular Informatics. 30: 133-6. PMID 27466764 DOI: 10.1002/Minf.201000126 |
0.368 |
|
| 2011 |
Giangreco I, Lattanzi G, Nicolotti O, Catto M, Laghezza A, Leonetti F, Stefanachi A, Carotti A. Insights into the complex formed by matrix metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations. Plos One. 6: e25597. PMID 21998672 DOI: 10.1371/Journal.Pone.0025597 |
0.339 |
|
| 2011 |
Pisani L, Catto M, Leonetti F, Nicolotti O, Stefanachi A, Campagna F, Carotti A. Targeting monoamine oxidases with multipotent ligands: an emerging strategy in the search of new drugs against neurodegenerative diseases. Current Medicinal Chemistry. 18: 4568-4587. PMID 21864289 DOI: 10.2174/092986711797379302 |
0.301 |
|
| 2011 |
Conejo-GarcÃa A, Pisani L, Núñez Mdel C, Catto M, Nicolotti O, Leonetti F, Campos JM, Gallo MA, Espinosa A, Carotti A. Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity. Journal of Medicinal Chemistry. 54: 2627-45. PMID 21417225 DOI: 10.1021/Jm101299D |
0.4 |
|
| 2011 |
Stefanachi A, Favia AD, Nicolotti O, Leonetti F, Pisani L, Catto M, Zimmer C, Hartmann RW, Carotti A. Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase Journal of Medicinal Chemistry. 54: 1613-1625. PMID 21341743 DOI: 10.1021/Jm101120U |
0.393 |
|
| 2010 |
Pisani L, Catto M, Giangreco I, Leonetti F, Nicolotti O, Stefanachi A, Cellamare S, Carotti A. Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors. Chemmedchem. 5: 1616-30. PMID 20677317 DOI: 10.1002/Cmdc.201000210 |
0.323 |
|
| 2010 |
Nicolotti O, Giangreco I, Miscioscia TF, Convertino M, Leonetti F, Pisani L, Carotti A. Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model. Journal of Computer-Aided Molecular Design. 24: 117-29. PMID 20148287 DOI: 10.1007/S10822-010-9320-1 |
0.374 |
|
| 2010 |
Pellegrino G, Leonetti F, Carotti A, Nicolotti O, Pisani L, Stefanachi A, Catto M. Solid phase synthesis of a molecular library of pyrimidines, pyrazoles, and isoxazoles with biological potential Tetrahedron Letters. 51: 1702-1705. DOI: 10.1016/J.Tetlet.2010.01.089 |
0.379 |
|
| 2009 |
Pisani L, Muncipinto G, Miscioscia TF, Nicolotti O, Leonetti F, Catto M, Caccia C, Salvati P, Soto-Otero R, Mendez-Alvarez E, Passeleu C, Carotti A. Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor. Journal of Medicinal Chemistry. 52: 6685-706. PMID 19810674 DOI: 10.1021/Jm9010127 |
0.394 |
|
| 2008 |
Stefanachi A, Nicolotti O, Leonetti F, Cellamare S, Campagna F, Loza MI, Brea JM, Mazza F, Gavuzzo E, Carotti A. 1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships. Bioorganic & Medicinal Chemistry. 16: 9780-9. PMID 18938084 DOI: 10.1016/J.Bmc.2008.09.067 |
0.322 |
|
| 2008 |
Leonetti F, Catto M, Nicolotti O, Pisani L, Cappa A, Stefanachi A, Carotti A. Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors. Bioorganic & Medicinal Chemistry. 16: 7450-6. PMID 18585045 DOI: 10.1016/J.Bmc.2008.06.022 |
0.361 |
|
| 2008 |
Nicolotti O, Miscioscia TF, Carotti A, Leonetti F, Carotti A. An integrated approach to ligand- and structure-based drug design: development and application to a series of serine protease inhibitors. Journal of Chemical Information and Modeling. 48: 1211-26. PMID 18540590 DOI: 10.1021/Ci800015S |
0.371 |
|
| 2007 |
Nicolotti O, Miscioscia TF, Leonetti F, Muncipinto G, Carotti A. Screening of matrix metalloproteinases available from the protein data bank: insights into biological functions, domain organization, and zinc binding groups. Journal of Chemical Information and Modeling. 47: 2439-48. PMID 17958346 DOI: 10.1021/Ci700119R |
0.309 |
|
| 2007 |
Carotti A, Catto M, Leonetti F, Campagna F, Soto-Otero R, Méndez-Alvarez E, Thull U, Testa B, Altomare C. Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives. Journal of Medicinal Chemistry. 50: 5364-71. PMID 17910428 DOI: 10.1021/Jm070728R |
0.373 |
|
| 2007 |
Leonetti F, Capaldi C, Pisani L, Nicolotti O, Muncipinto G, Stefanachi A, Cellamare S, Caccia C, Carotti A. Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase. Journal of Medicinal Chemistry. 50: 4909-16. PMID 17824599 DOI: 10.1021/Jm070725E |
0.375 |
|
| 2007 |
Leonetti F, Capaldi C, Carotti A. Microwave-assisted solid phase synthesis of Imatinib, a blockbuster anticancer drug Tetrahedron Letters. 48: 3455-3458. DOI: 10.1016/J.Tetlet.2007.03.033 |
0.361 |
|
| 2006 |
Novaroli L, Daina A, Favre E, Bravo J, Carotti A, Leonetti F, Catto M, Carrupt PA, Reist M. Impact of species-dependent differences on screening, design, and development of MAO B inhibitors. Journal of Medicinal Chemistry. 49: 6264-72. PMID 17034132 DOI: 10.1021/Jm060441E |
0.336 |
|
| 2006 |
Catto M, Nicolotti O, Leonetti F, Carotti A, Favia AD, Soto-Otero R, Méndez-Álvarez E. Structural insights into monoamine oxidase inhibitory potency and selectivity of 7-substituted coumarins from ligand- and target-based approaches Journal of Medicinal Chemistry. 49: 4912-4925. PMID 16884303 DOI: 10.1021/Jm060183L |
0.373 |
|
| 2006 |
Choe Y, Leonetti F, Greenbaum DC, Lecaille F, Bogyo M, Brömme D, Ellman JA, Craik CS. Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities. The Journal of Biological Chemistry. 281: 12824-32. PMID 16520377 DOI: 10.1074/Jbc.M513331200 |
0.582 |
|
| 2004 |
Leonetti F, Favia A, Rao A, Aliano R, Paluszcak A, Hartmann RW, Carotti A. Design, synthesis, and 3D QSAR of novel potent and selective aromatase inhibitors Journal of Medicinal Chemistry. 47: 6792-6803. PMID 15615528 DOI: 10.1021/Jm049535J |
0.375 |
|
| 2004 |
Leonetti F, Cappa A, Maccallini C, Carotti A. Synthesis of potential dual binding site acetylcholinesterase inhibitors through an efficient solid phase approach based on the Mitsunobu reaction Arkivoc. 2004. DOI: 10.3998/Ark.5550190.0005.524 |
0.374 |
|
| 2003 |
Boitano A, Emal CD, Leonetti F, Blatt NB, Dineen TA, Ellman JA, Roush WR, Opipari AW, Glick GD. Structure activity studies of a novel cytotoxic benzodiazepine. Bioorganic & Medicinal Chemistry Letters. 13: 3327-30. PMID 12951119 DOI: 10.1016/S0960-894X(03)00683-8 |
0.497 |
|
| 2003 |
Bednarski JJ, Warner RE, Rao T, Leonetti F, Yung R, Richardson BC, Johnson KJ, Ellman JA, Opipari AW, Glick GD. Attenuation of autoimmune disease in Fas-deficient mice by treatment with a cytotoxic benzodiazepine. Arthritis and Rheumatism. 48: 757-66. PMID 12632430 DOI: 10.1002/Art.10968 |
0.455 |
|
| 2003 |
Stefanachi A, Leonetti F, Cappa A, Carotti A. Fast and highly efficient one-pot synthesis of 9-deazaxanthines Tetrahedron Letters. 44: 2121-2123. DOI: 10.1016/S0040-4039(03)00173-4 |
0.304 |
|
| 2002 |
Blatt NB, Bednarski JJ, Warner RE, Leonetti F, Johnson KM, Boitano A, Yung R, Richardson BC, Johnson KJ, Ellman JA, Opipari AW, Glick GD. Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility. The Journal of Clinical Investigation. 110: 1123-32. PMID 12393848 DOI: 10.1172/Jci16029 |
0.48 |
|
| 2002 |
Maly DJ, Leonetti F, Backes BJ, Dauber DS, Harris JL, Craik CS, Ellman JA. Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore. The Journal of Organic Chemistry. 67: 910-5. PMID 11856036 DOI: 10.1021/Jo016140O |
0.697 |
|
| 2001 |
Brühlmann C, Ooms F, Carrupt P, Testa B, Catto M, Leonetti F, Altomare C, Carotti A. Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase Journal of Medicinal Chemistry. 44: 3195-3198. PMID 11543689 DOI: 10.1021/Jm010894D |
0.343 |
|
| 2000 |
Gnerre C, Catto M, Leonetti F, Weber P, Carrupt †P, Altomare C, Carotti aA, Testa B. Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activities, QSARs, and 3D-QSARs. Journal of Medicinal Chemistry. 43: 4747-4758. PMID 11123983 DOI: 10.1021/Jm001028O |
0.35 |
|
| 2000 |
Harris JL, Backes BJ, Leonetti F, Mahrus S, Ellman JA, Craik CS. Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries. Proceedings of the National Academy of Sciences of the United States of America. 97: 7754-9. PMID 10869434 DOI: 10.1073/Pnas.140132697 |
0.71 |
|
| 2000 |
Backes BJ, Harris JL, Leonetti F, Craik CS, Ellman JA. Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin. Nature Biotechnology. 18: 187-93. PMID 10657126 DOI: 10.1038/72642 |
0.689 |
|
| 2000 |
Backes BJ, Harris JL, Leonetti F, Craik CS, Ellman JA. Erratum: Erratum to “Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin” Nature Biotechnology. 18: 559-559. DOI: 10.1038/75441 |
0.513 |
|
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