| Year |
Citation |
Score |
| 2023 |
Ericson MD, Freeman KT, LaVoi TM, Donow HM, Santos RG, Giulianotti MA, Pinilla C, Houghten RA, Haskell-Luevano C. The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands. International Journal of Molecular Sciences. 24. PMID 37373293 DOI: 10.3390/ijms241210145 |
0.327 |
|
| 2023 |
Ericson MD, Tran LT, Mathre SS, Freeman KT, Holdaway K, John K, Lunzer MM, Bouchard JL, Haskell-Luevano C. Discovery of a Pan-Melanocortin Receptor Antagonist [Ac-DPhe(pI)-Arg-Nal(2')-Orn-NH] at the MC1R, MC3R, MC4R, and MC5R that Mediates an Increased Feeding Response in Mice and a 40-Fold Selective MC1R Antagonist [Ac-DPhe(pI)-DArg-Nal(2')-Arg-NH]. Journal of Medicinal Chemistry. PMID 37307241 DOI: 10.1021/acs.jmedchem.3c00432 |
0.429 |
|
| 2022 |
Ericson MD, Larson CM, Freeman KT, Nicke L, Geyer A, Haskell-Luevano C. Incorporation of Indoylated Phenylalanine Yields a Sub-Micromolar Selective Melanocortin-4 Receptor Antagonist Tetrapeptide. Acs Omega. 7: 27656-27663. PMID 35967074 DOI: 10.1021/acsomega.2c03307 |
0.425 |
|
| 2021 |
Ericson MD, Doering SR, Larson CM, Freeman KT, LaVoi TM, Donow HM, Santos RG, Cho RH, Koerperich ZM, Giulianotti MA, Pinilla C, Houghten RA, Haskell-Luevano C. Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist. Journal of Medicinal Chemistry. PMID 34592820 DOI: 10.1021/acs.jmedchem.1c01417 |
0.409 |
|
| 2021 |
Doering SR, Freeman K, Debevec G, Geer P, Santos RG, Lavoi TM, Giulianotti MA, Pinilla C, Appel JR, Houghten RA, Ericson MD, Haskell-Luevano C. Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign. Journal of Medicinal Chemistry. PMID 33886285 DOI: 10.1021/acs.jmedchem.0c02041 |
0.412 |
|
| 2021 |
Koikov L, Starner RJ, Swope VB, Upadhyay P, Hashimoto Y, Freeman KT, Knittel JJ, Haskell-Luevano C, Abdel-Malek ZA. Development of hMC1R Selective Small Agonists for Sunless Tanning and Prevention of Genotoxicity of UV in Melanocytes. The Journal of Investigative Dermatology. PMID 33609553 DOI: 10.1016/j.jid.2020.11.034 |
0.304 |
|
| 2021 |
Ericson MD, Shaikh R, Larson CM, Freeman KT, Haskell-Luevano C. Multiresidue Tetrapeptide Substitutions Yield a 140-fold Selective Melanocortin-3 over Melanocortin-4 Receptor Agonist. Acs Medicinal Chemistry Letters. 12: 115-120. PMID 33488972 DOI: 10.1021/acsmedchemlett.0c00561 |
0.417 |
|
| 2021 |
Ericson MD, Haslach EM, Schnell SM, Freeman KT, Xiang ZM, Portillo FP, Speth R, Litherland SA, Haskell-Luevano C. Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R. Acs Chemical Neuroscience. 12: 542-556. PMID 33470098 DOI: 10.1021/acschemneuro.0c00755 |
0.447 |
|
| 2020 |
Ericson MD, Freeman KT, Haskell-Luevano C. Peptoid NPhe in AGRP-Based c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro] Scaffolds Maintain Mouse MC4R Antagonist Potency. Acs Medicinal Chemistry Letters. 11: 1942-1948. PMID 33062177 DOI: 10.1021/Acsmedchemlett.9B00641 |
0.502 |
|
| 2020 |
Adank DN, Lunzer MM, Ericson MD, Koerperich ZM, Wilber SL, Fleming KA, Haskell-Luevano C. Comparative intracerebroventricular (ICV) and intrathecal (IT) administration of a nanomolar macrocyclic melanocortin receptor agonist MDE6-5-2c (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro]) decreases food intake in mice. Acs Chemical Neuroscience. PMID 32822157 DOI: 10.1021/Acschemneuro.0C00409 |
0.426 |
|
| 2020 |
Winget MD, Ericson MD, Freeman KT, Haskell-Luevano C. Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy. Acs Medicinal Chemistry Letters. 11: 272-277. PMID 32184956 DOI: 10.1021/Acsmedchemlett.9B00198 |
0.443 |
|
| 2019 |
Koerperich ZM, Ericson MD, Freeman KT, Speth R, Pogozheva ID, Mosberg HI, Haskell-Luevano C. Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AGRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists. Journal of Medicinal Chemistry. PMID 31845801 DOI: 10.1021/Acs.Jmedchem.9B00860 |
0.515 |
|
| 2019 |
Schlasner KN, Ericson MD, Doering SR, Freeman KT, Weinrich M, Haskell-Luevano C. Structure⁻Activity Relationships of the Tetrapeptide Ac-His-Arg-(I)DPhe-Tic-NH at the Mouse Melanocortin Receptors: Modification at the (I)DPhe Position Leads to mMC3R Versus mMC4R Selective Ligands. Molecules (Basel, Switzerland). 24. PMID 31013889 DOI: 10.3390/Molecules24081463 |
0.514 |
|
| 2019 |
Fleming KA, Freeman KT, Powers MD, Santos RG, Debevec G, Giulianotti MA, Houghten RA, Doering SR, Pinilla C, Haskell-Luevano C. Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a µM MC4R Partial Agonist. Journal of Medicinal Chemistry. PMID 30741545 DOI: 10.1021/Acs.Jmedchem.9B00053 |
0.486 |
|
| 2018 |
Fleming K, Freeman KT, Ericson MD, Haskell-Luevano C. Synergistic Multi-Residue Substitutions of a Macrocyclic c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Agouti-Related Protein (AGRP) Scaffold Yield Potent and >600-Fold MC4R versus MC3R Selective Melanocortin Receptor Antagonists. Journal of Medicinal Chemistry. PMID 30035543 DOI: 10.1021/Acs.Jmedchem.8B00684 |
0.49 |
|
| 2018 |
Ericson MD, Koerperich ZM, Freeman KT, Fleming KA, Haskell-Luevano C. Arg-Phe-Phe D-Amino Acid Stereochemistry Scan in the Macrocyclic Agouti-Related Protein Antagonist Scaffold c[Pro-Arg-Phe-Phe-Xaa-Ala-Phe-DPro] Results in Unanticipated Melanocortin-1 Receptor Agonist Profiles. Acs Chemical Neuroscience. PMID 29924583 DOI: 10.1021/Acschemneuro.8B00218 |
0.533 |
|
| 2018 |
Todorovic A, Lensing CJ, Holder JR, Scott JW, Sorensen NB, Haskell-Luevano C. Discovery of melanocortin ligands via a double simultaneous substitution strategy based on the Ac-His-DPhe-Arg-Trp-NH template. Acs Chemical Neuroscience. PMID 29783840 DOI: 10.1021/Acschemneuro.8B00181 |
0.485 |
|
| 2018 |
Ericson MD, Haskell-Luevano C. A Review of Single-Nucleotide Polymorphisms (SNPs) in Orexigenic Neuropeptides Targeting G-Protein Coupled Receptors (GPCRs). Acs Chemical Neuroscience. PMID 29714060 DOI: 10.1021/Acschemneuro.8B00151 |
0.373 |
|
| 2018 |
Lensing CJ, Freeman KT, Schnell SM, Speth RC, Zarth AT, Haskell-Luevano C. Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β-Arrestin2 Recruitment) Within the Melanocortin Receptors. Journal of Medicinal Chemistry. PMID 29669202 DOI: 10.1021/Acs.Jmedchem.8B00238 |
0.482 |
|
| 2018 |
Ericson MD, Singh A, Tala SR, Haslach EM, Dirain MLS, Schaub JW, Flores V, Eick N, Lensing CJ, Freeman KT, Smeester BA, Adank DN, Wilber SL, Speth R, Haskell-Luevano C. Human β-Defensin-1 and β-Defensin-3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors. Journal of Medicinal Chemistry. PMID 29578343 DOI: 10.1021/Acs.Jmedchem.8B00251 |
0.608 |
|
| 2018 |
Fleming KA, Ericson MD, Freeman KT, Adank DN, Lunzer MM, Wilber SL, Haskell-Luevano C. Structure-Activity Relationship Studies of a Macrocyclic AGRP-Mimetic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Yield Potent and Selective Melanocortin-4 Receptor Antagonists and Melanocortin-5 Receptor Inverse Agonists that Increase Food Intake in Mice. Acs Chemical Neuroscience. PMID 29363944 DOI: 10.1021/Acschemneuro.7B00495 |
0.56 |
|
| 2017 |
Tala SR, Singh A, Lensing CJ, Schnell SM, Freeman KT, Rocca JR, Haskell-Luevano C. 1,2,3-Triazole Rings as a Disulfide Bond Mimetic in Chimeric AGRP-Melanocortin Peptides: Design, Synthesis, and Functional Characterization. Acs Chemical Neuroscience. PMID 29257879 DOI: 10.1021/Acschemneuro.7B00422 |
0.555 |
|
| 2017 |
Adank DN, Lunzer MM, Lensing CJ, Wilber SL, Gancarz AM, Haskell-Luevano C. Comparative In Vivo Investigation of Intrathecal and Intracerebroventricular Administration with Melanocortin Ligands MTII and AGRP into Mice. Acs Chemical Neuroscience. PMID 28968061 DOI: 10.1021/Acschemneuro.7B00330 |
0.436 |
|
| 2017 |
Ericson MD, Freeman KT, Schnell SM, Fleming KA, Haskell-Luevano C. Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin-5 Receptor. Journal of Medicinal Chemistry. PMID 28813605 DOI: 10.1021/Acs.Jmedchem.7B00856 |
0.526 |
|
| 2017 |
Doering SR, Freeman KT, Schnell SM, Haslach EM, Dirain MLS, Ginamarie Debevec G, Geer P, Santos RG, Giulianotti MA, Pinilla C, Appel JR, Speth RC, Houghten RA, Haskell-Luevano C. Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa(1)-Arg-(pI)DPhe-Xaa((4))-NH2. Journal of Medicinal Chemistry. PMID 28453292 DOI: 10.1021/Acs.Jmedchem.7B00301 |
0.509 |
|
| 2017 |
Ericson MD, Lensing CJ, Fleming KA, Schlasner KN, Doering SR, Haskell-Luevano C. Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016. Biochimica Et Biophysica Acta. PMID 28363699 DOI: 10.1016/J.Bbadis.2017.03.020 |
0.396 |
|
| 2017 |
Lensing CJ, Adank DN, Wilber SL, Freeman KT, Schnell SM, Speth RC, Zarth AT, Haskell-Luevano C. A Direct In Vivo Comparison of The Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus The Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage. Acs Chemical Neuroscience. PMID 28128928 DOI: 10.1021/Acschemneuro.6B00399 |
0.437 |
|
| 2017 |
Ericson MD, Freeman KT, Schnell SM, Haskell-Luevano C. A Macrocyclic Agouti-Related Protein/[Nle(4), DPhe(7)]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Sub-nanomolar Melanocortin Receptor Ligands. Journal of Medicinal Chemistry. PMID 28045525 DOI: 10.1021/Acs.Jmedchem.6B01707 |
0.552 |
|
| 2016 |
Lensing CJ, Adank DN, Doering SR, Wilber SL, Andreasen A, Schaub JW, Xiang Z, Haskell-Luevano C. The Ac-Trp-DPhe(p-I)-Arg-Trp-NH2 250-Fold Selective Melanocortin-4 Receptor (MC4R) Antagonist over the Melanocortin-3 Receptor (MC3R) Affects Energy Homeostasis in Male and Female Mice Differently. Acs Chemical Neuroscience. PMID 27385405 DOI: 10.1021/Acschemneuro.6B00156 |
0.609 |
|
| 2016 |
Todorovic A, Ericson MD, Palusak RD, Sorensen NB, Wood MS, Xiang Z, Haskell-Luevano C. Comparative Functional Alanine Positional Scanning of the α-Melanocyte Stimulating Hormone and NDP-Melanocyte Stimulating Hormone Demonstrates Differential Structure-Activity Relationships at the Mouse Melanocortin Receptors. Acs Chemical Neuroscience. PMID 27135265 DOI: 10.1021/Acschemneuro.6B00098 |
0.51 |
|
| 2016 |
Lensing CJ, Freeman KT, Schnell SM, Adank DN, Haskell-Luevano C. An in vitro and in vivo investigation of bivalent ligands that display preferential binding and functional activity for different melanocortin receptor homodimers. Journal of Medicinal Chemistry. PMID 26959173 DOI: 10.1021/Acs.Jmedchem.5B01894 |
0.47 |
|
| 2015 |
Singh A, Kast J, Dirain ML, Huang H, Haskell-Luevano C. Synthesis and Structure-Activity Relationships of Substituted Urea Derivatives on Mouse Melanocortin Receptors. Acs Chemical Neuroscience. PMID 26645732 DOI: 10.1021/Acschemneuro.5B00273 |
0.433 |
|
| 2015 |
Tala SR, Schnell SM, Haskell-Luevano C. Microwave-assisted solid-phase synthesis of side-chain to side-chain lactam-bridge cyclic peptides. Bioorganic & Medicinal Chemistry Letters. PMID 26555357 DOI: 10.1016/J.Bmcl.2015.10.095 |
0.343 |
|
| 2015 |
Ericson MD, Schnell SM, Freeman KT, Haskell-Luevano C. A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist. Bioorganic & Medicinal Chemistry Letters. 25: 5306-8. PMID 26433448 DOI: 10.1016/J.Bmcl.2015.09.046 |
0.466 |
|
| 2015 |
Singh A, Tala SR, Flores V, Freeman K, Haskell-Luevano C. Synthesis and Pharmacology of α/β(3)-Peptides Based on the Melanocortin Agonist Ac-His-dPhe-Arg-Trp-NH2 Sequence. Acs Medicinal Chemistry Letters. 6: 568-72. PMID 26005535 DOI: 10.1021/Acsmedchemlett.5B00053 |
0.467 |
|
| 2015 |
Ericson MD, Wilczynski A, Sorensen NB, Xiang Z, Haskell-Luevano C. Discovery of a β-Hairpin Octapeptide, c[Pro-Arg-Phe-Phe-Dap-Ala-Phe-DPro], Mimetic of Agouti-Related Protein(87-132) [AGRP(87-132)] with Equipotent Mouse Melanocortin-4 Receptor (mMC4R) Antagonist Pharmacology. Journal of Medicinal Chemistry. 58: 4638-47. PMID 25898270 DOI: 10.1021/Acs.Jmedchem.5B00184 |
0.514 |
|
| 2015 |
Doering SR, Todorovic A, Haskell-Luevano C. Melanocortin antagonist tetrapeptides with minimal agonist activity at the mouse melanocortin-3 receptor. Acs Medicinal Chemistry Letters. 6: 123-7. PMID 25699138 DOI: 10.1021/Ml500340Z |
0.523 |
|
| 2014 |
Testa C, Scrima M, Grimaldi M, D'Ursi AM, Dirain ML, Lubin-Germain N, Singh A, Haskell-Luevano C, Chorev M, Rovero P, Papini AM. 1,4-disubstituted-[1,2,3]triazolyl-containing analogues of MT-II: design, synthesis, conformational analysis, and biological activity. Journal of Medicinal Chemistry. 57: 9424-34. PMID 25347033 DOI: 10.1021/Jm501027W |
0.404 |
|
| 2014 |
Singh A, Dirain ML, Wilczynski A, Chen C, Gosnell BA, Levine AS, Edison AS, Haskell-Luevano C. Synthesis, biophysical, and pharmacological evaluation of the melanocortin agonist AST3-88: modifications of peptide backbone at Trp 7 position lead to a potent, selective, and stable ligand of the melanocortin 4 receptor (MC4R). Acs Chemical Neuroscience. 5: 1020-31. PMID 25141170 DOI: 10.1021/Cn5000953 |
0.535 |
|
| 2014 |
Haslach EM, Huang H, Dirain M, Debevec G, Geer P, Santos RG, Giulianotti MA, Pinilla C, Appel JR, Doering SR, Walters MA, Houghten RA, Haskell-Luevano C. Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs). Journal of Medicinal Chemistry. 57: 4615-28. PMID 24517312 DOI: 10.1021/Jm500064T |
0.449 |
|
| 2013 |
Singh A, Dirain M, Witek R, Rocca JR, Edison AS, Haskell-Luevano C. Structure-activity relationships of peptides incorporating a bioactive reverse-turn heterocycle at the melanocortin receptors: identification of a 5800-fold mouse melanocortin-3 receptor (mMC3R) selective antagonist/partial agonist versus the mouse melanocortin-4 receptor (mMC4R). Journal of Medicinal Chemistry. 56: 2747-63. PMID 23432160 DOI: 10.1021/Jm301253Y |
0.559 |
|
| 2011 |
Singh A, Wilczynski A, Holder JR, Witek RM, Dirain ML, Xiang Z, Edison AS, Haskell-Luevano C. Incorporation of a bioactive reverse-turn heterocycle into a peptide template using solid-phase synthesis to probe melanocortin receptor selectivity and ligand conformations by 2D 1H NMR. Journal of Medicinal Chemistry. 54: 1379-90. PMID 21306168 DOI: 10.1021/Jm101425M |
0.52 |
|
| 2011 |
Hinkle PM, Serasinghe MN, Jakabowski A, Sebag JA, Wilson KR, Haskell-Luevano C. Use of chimeric melanocortin-2 and -4 receptors to identify regions responsible for ligand specificity and dependence on melanocortin 2 receptor accessory protein. European Journal of Pharmacology. 660: 94-102. PMID 21211532 DOI: 10.1016/J.Ejphar.2010.10.113 |
0.487 |
|
| 2011 |
Irani BG, Xiang Z, Yarandi HN, Holder JR, Moore MC, Bauzo RM, Proneth B, Shaw AM, Millard WJ, Chambers JB, Benoit SC, Clegg DJ, Haskell-Luevano C. Implication of the melanocortin-3 receptor in the regulation of food intake. European Journal of Pharmacology. 660: 80-7. PMID 21199647 DOI: 10.1016/J.Ejphar.2010.10.101 |
0.37 |
|
| 2010 |
Schaub JW, Bruce EB, Haskell-Luevano C. Drugs, exercise, and the melanocortin-4 receptor-- different means, same ends: treating obesity. Advances in Experimental Medicine and Biology. 681: 49-60. PMID 21222259 DOI: 10.1007/978-1-4419-6354-3_4 |
0.568 |
|
| 2010 |
Singh A, Haslach EM, Haskell-Luevano C. Structure-activity relationships (SAR) of melanocortin and agouti-related (AGRP) peptides. Advances in Experimental Medicine and Biology. 681: 1-18. PMID 21222256 DOI: 10.1007/978-1-4419-6354-3_1 |
0.478 |
|
| 2010 |
Joseph CG, Yao H, Scott JW, Sorensen NB, Marnane RN, Mountjoy KG, Haskell-Luevano C. γ₂-Melanocyte stimulation hormone (γ₂-MSH) truncation studies results in the cautionary note that γ₂-MSH is not selective for the mouse MC3R over the mouse MC5R. Peptides. 31: 2304-13. PMID 20833220 DOI: 10.1016/J.Peptides.2010.08.025 |
0.535 |
|
| 2010 |
Rowland NE, Schaub JW, Robertson KL, Andreasen A, Haskell-Luevano C. Effect of MTII on food intake and brain c-Fos in melanocortin-3, melanocortin-4, and double MC3 and MC4 receptor knockout mice. Peptides. 31: 2314-7. PMID 20800636 DOI: 10.1016/J.Peptides.2010.08.016 |
0.631 |
|
| 2010 |
Xiang Z, Proneth B, Dirain ML, Litherland SA, Haskell-Luevano C. Pharmacological characterization of 30 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists, synthetic agonists, and the endogenous agouti-related protein antagonist. Biochemistry. 49: 4583-600. PMID 20462274 DOI: 10.1021/Bi100068U |
0.476 |
|
| 2010 |
Atalayer D, Robertson KL, Haskell-Luevano C, Andreasen A, Rowland NE. Food demand and meal size in mice with single or combined disruption of melanocortin type 3 and 4 receptors. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 298: R1667-74. PMID 20375267 DOI: 10.1152/Ajpregu.00562.2009 |
0.39 |
|
| 2010 |
Rowland NE, Fakhar KJ, Robertson KL, Haskell-Luevano C. Effect of serotonergic anorectics on food intake and induction of Fos in brain of mice with disruption of melanocortin 3 and/or 4 receptors. Pharmacology, Biochemistry, and Behavior. 97: 107-11. PMID 20347864 DOI: 10.1016/J.Pbb.2010.03.008 |
0.441 |
|
| 2010 |
Ovadia O, Linde Y, Haskell-Luevano C, Dirain ML, Sheynis T, Jelinek R, Gilon C, Hoffman A. The effect of backbone cyclization on PK/PD properties of bioactive peptide-peptoid hybrids: the melanocortin agonist paradigm. Bioorganic & Medicinal Chemistry. 18: 580-9. PMID 20056544 DOI: 10.1016/J.Bmc.2009.12.010 |
0.431 |
|
| 2009 |
Ruwe AR, Koikov L, Abdel-Malek Z, Haskell-Luevano C, Dirain ML, Portillo F, Xiang Z, Wortman M, Knittel JJ. Semi-rigid tripeptide agonists of melanocortin receptors. Bioorganic & Medicinal Chemistry Letters. 19: 5176-81. PMID 19635667 DOI: 10.1016/J.Bmcl.2009.07.025 |
0.367 |
|
| 2009 |
Abdel-Malek ZA, Ruwe A, Kavanagh-Starner R, Kadekaro AL, Swope V, Haskell-Luevano C, Koikov L, Knittel JJ. alpha-MSH tripeptide analogs activate the melanocortin 1 receptor and reduce UV-induced DNA damage in human melanocytes. Pigment Cell & Melanoma Research. 22: 635-44. PMID 19558415 DOI: 10.1111/J.1755-148X.2009.00598.X |
0.362 |
|
| 2009 |
Haskell-Luevano C, Xiang Z, Wilczynski AM, Haskell KR, Andreasen AM, Litherland SA, Millard WJ, Pogozheva ID, Mosberg HI, Sorenson NB. Discovery of a ligand that compensates for decreased endogenous agonist potency of melanocortin-4 receptor polymorphisms identified in obese humans. Advances in Experimental Medicine and Biology. 611: 509-10. PMID 19400288 DOI: 10.1007/978-0-387-73657-0_221 |
0.449 |
|
| 2009 |
Proneth B, Portillo FP, Haskell-Luevano C. A combination of ligand SAR and receptor site-directed mutagenesis reveals requirements for antagonist activity at the melanocortin-3 receptor. Advances in Experimental Medicine and Biology. 611: 319-20. PMID 19400209 DOI: 10.1007/978-0-387-73657-0_142 |
0.539 |
|
| 2009 |
Wilson KR, Proneth B, Luesch H, Litherland SA, Haskell-Luevano C. Construction and characterization of melanocortin-2 and -4 receptor chimeras. Advances in Experimental Medicine and Biology. 611: 301-2. PMID 19400202 DOI: 10.1007/978-0-387-73657-0_135 |
0.458 |
|
| 2009 |
Haskell-Luevano C, Schaub JW, Andreasen A, Haskell KR, Moore MC, Koerper LM, Rouzaud F, Baker HV, Millard WJ, Walter G, Litherland SA, Xiang Z. Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 642-55. PMID 18971258 DOI: 10.1096/Fj.08-109686 |
0.575 |
|
| 2009 |
Haslach EM, Schaub JW, Haskell-Luevano C. Beta-turn secondary structure and melanocortin ligands. Bioorganic & Medicinal Chemistry. 17: 952-8. PMID 18343128 DOI: 10.1016/J.Bmc.2008.02.090 |
0.642 |
|
| 2009 |
Rowland N, Robertson K, Mcleod D, Haskell-Luevano C. Fos expression in brain of MC4R, MC3R, and double receptor knockout mice in response to CCK, BN or MTII Appetite. 52: 854. DOI: 10.1016/J.Appet.2009.04.165 |
0.373 |
|
| 2008 |
Proneth B, Pogozheva ID, Portillo FP, Mosberg HI, Haskell-Luevano C. Melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 modified at the para position of the benzyl side chain (DPhe): importance for mouse melanocortin-3 receptor agonist versus antagonist activity. Journal of Medicinal Chemistry. 51: 5585-93. PMID 18800761 DOI: 10.1021/Jm800291B |
0.534 |
|
| 2008 |
Linde Y, Ovadia O, Safrai E, Xiang Z, Portillo FP, Shalev DE, Haskell-Luevano C, Hoffman A, Gilon C. Structure-activity relationship and metabolic stability studies of backbone cyclization and N-methylation of melanocortin peptides. Biopolymers. 90: 671-82. PMID 18655141 DOI: 10.1002/Bip.21057 |
0.409 |
|
| 2008 |
Joseph CG, Wilson KR, Wood MS, Sorenson NB, Phan DV, Xiang Z, Witek RM, Haskell-Luevano C. The 1,4-benzodiazepine-2,5-dione small molecule template results in melanocortin receptor agonists with nanomolar potencies. Journal of Medicinal Chemistry. 51: 1423-31. PMID 18271518 DOI: 10.1021/Jm701303Z |
0.522 |
|
| 2008 |
Hess S, Linde Y, Ovadia O, Safrai E, Shalev DE, Swed A, Halbfinger E, Lapidot T, Winkler I, Gabinet Y, Faier A, Yarden D, Xiang Z, Portillo FP, Haskell-Luevano C, et al. Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity. Journal of Medicinal Chemistry. 51: 1026-34. PMID 18220330 DOI: 10.1021/Jm701093Y |
0.437 |
|
| 2007 |
Katritzky AR, Khashab NM, Yoshioka M, Haase DN, Wilson KR, Johnson JV, Chung A, Haskell-Luevano C. Microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected (alpha-aminoacyl)benzotriazoles. Chemical Biology & Drug Design. 70: 465-8. PMID 17949361 DOI: 10.1111/J.1747-0285.2007.00584.X |
0.318 |
|
| 2007 |
Xiang Z, Pogozheva ID, Sorenson NB, Wilczynski AM, Holder JR, Litherland SA, Millard WJ, Mosberg HI, Haskell-Luevano C. Peptide and small molecules rescue the functional activity and agonist potency of dysfunctional human melanocortin-4 receptor polymorphisms. Biochemistry. 46: 8273-87. PMID 17590021 DOI: 10.1021/Bi7007382 |
0.522 |
|
| 2007 |
Todorovic A, Joseph CG, Sorensen NB, Wood MS, Haskell-Luevano C. Structure-activity relationships of melanocortin agonists containing the benzimidazole scaffold. Chemical Biology & Drug Design. 69: 338-49. PMID 17539826 DOI: 10.1111/J.1747-0285.2007.00511.X |
0.52 |
|
| 2007 |
Xiang Z, Sorenson N, Wilczynski AM, Haskell KR, Andreasen AM, Haskell-Luevano C. A Ligand Template that Functionally Corrects Eleven Melanocortin-4 Receptor (MC4R) Polymorphisms The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A460-C |
0.429 |
|
| 2007 |
Mathes C, Ferrara M, Suresh D, Andreasen A, Haskell-Luevano C, Rowland N. Effect of level of dysfunction of the melanocortin-4 receptor (MC4R) on overconsumption and binge-like eating of a palatable dessert in mice. Appetite. 49: 312. DOI: 10.1016/J.Appet.2007.03.133 |
0.342 |
|
| 2006 |
Vaughan CH, Haskell-Luevano C, Andreasen A, Rowland NE. Effects of oral preload, CCK or bombesin administration on short term food intake of melanocortin 4-receptor knockout (MC4RKO) mice. Peptides. 27: 3226-33. PMID 16963158 DOI: 10.1016/J.Peptides.2006.08.002 |
0.317 |
|
| 2006 |
Vaughan C, Moore M, Haskell-Luevano C, Rowland NE. Food motivated behavior of melanocortin-4 receptor knockout mice under a progressive ratio schedule. Peptides. 27: 2829-35. PMID 16930774 DOI: 10.1016/J.Peptides.2006.07.008 |
0.325 |
|
| 2006 |
Wilson KR, Todorovic A, Proneth B, Haskell-Luevano C. Overview of endogenous and synthetic melanocortin peptides. Cellular and Molecular Biology (Noisy-Le-Grand, France). 52: 3-20. PMID 16914082 |
0.46 |
|
| 2006 |
Xiang Z, Litherland SA, Sorensen NB, Proneth B, Wood MS, Shaw AM, Millard WJ, Haskell-Luevano C. Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist. Biochemistry. 45: 7277-88. PMID 16752916 DOI: 10.1021/Bi0600300 |
0.512 |
|
| 2006 |
Chen M, Georgeson KE, Harmon CM, Haskell-Luevano C, Yang Y. Functional characterization of the modified melanocortin peptides responsible for ligand selectivity at the human melanocortin receptors. Peptides. 27: 2836-45. PMID 16730390 DOI: 10.1016/J.Peptides.2006.04.012 |
0.517 |
|
| 2006 |
Abdel-Malek ZA, Kadekaro AL, Kavanagh RJ, Todorovic A, Koikov LN, McNulty JC, Jackson PJ, Millhauser GL, Schwemberger S, Babcock G, Haskell-Luevano C, Knittel JJ. Melanoma prevention strategy based on using tetrapeptide alpha-MSH analogs that protect human melanocytes from UV-induced DNA damage and cytotoxicity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 1561-3. PMID 16723376 DOI: 10.1096/Fj.05-5655Fje |
0.359 |
|
| 2006 |
Boeglin D, Xiang Z, Sorenson NB, Wood MS, Haskell-Luevano C, Lubell WD. Aza-scanning of the potent melanocortin receptor agonist Ac-His-D-Phe-Arg-Trp-NH. Chemical Biology & Drug Design. 67: 275-83. PMID 16629825 DOI: 10.1111/J.1747-0285.2006.00378.X |
0.499 |
|
| 2006 |
Proneth B, Xiang Z, Pogozheva ID, Litherland SA, Gorbatyuk OS, Shaw AM, Millard WJ, Mosberg HI, Haskell-Luevano C. Molecular mechanism of the constitutive activation of the L250Q human melanocortin-4 receptor polymorphism. Chemical Biology & Drug Design. 67: 215-29. PMID 16611215 DOI: 10.1111/J.1747-0285.2006.00362.X |
0.499 |
|
| 2006 |
Murray JF, Hahn JD, Kennedy AR, Small CJ, Bloom SR, Haskell-Luevano C, Coen CW, Wilson CA. Evidence for a stimulatory action of melanin-concentrating hormone on luteinising hormone release involving MCH1 and melanocortin-5 receptors. Journal of Neuroendocrinology. 18: 157-67. PMID 16454799 DOI: 10.1111/J.1365-2826.2005.01397.X |
0.312 |
|
| 2006 |
Irani BG, Holder JR, Todorovic A, Wilezynski AM, Joseph CG, Wilson KR, Haskell-Luevano C. Development of melanocortin receptor selective ligands Frontiers in Medicinal Chemistry. 3: 285-334. |
0.348 |
|
| 2005 |
Joseph CG, Sorensen NB, Wood MS, Xiang Z, Moore MC, Haskell-Luevano C. Modified melanocortin tetrapeptide Ac-His-dPhe-Arg-Trp-NH at the arginine side chain with ureas and thioureas. The Journal of Peptide Research : Official Journal of the American Peptide Society. 66: 297-307. PMID 16218996 DOI: 10.1111/J.1399-3011.2005.00303.X |
0.523 |
|
| 2005 |
Todorovic A, Haskell-Luevano C. A review of melanocortin receptor small molecule ligands. Peptides. 26: 2026-36. PMID 16051395 DOI: 10.1016/J.Peptides.2004.11.024 |
0.508 |
|
| 2005 |
Irani BG, Haskell-Luevano C. Feeding effects of melanocortin ligands--a historical perspective. Peptides. 26: 1788-99. PMID 16046247 DOI: 10.1016/J.Peptides.2004.11.038 |
0.357 |
|
| 2005 |
Wilczynski AM, Joseph CG, Haskell-Luevano C. Current trends in the structure-activity relationship studies of the endogenous agouti-related protein (AGRP) melanocortin receptor antagonist. Medicinal Research Reviews. 25: 545-56. PMID 16044415 DOI: 10.1002/Med.20037 |
0.447 |
|
| 2005 |
Shaw AM, Irani BG, Moore MC, Haskell-Luevano C, Millard WJ. Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice. Peptides. 26: 1720-7. PMID 16005545 DOI: 10.1016/J.Peptides.2004.12.026 |
0.373 |
|
| 2005 |
Eylam S, Moore M, Haskell-Luevano C, Spector AC. Melanocortin-4 receptor-null mice display normal affective licking responses to prototypical taste stimuli in a brief-access test. Peptides. 26: 1712-9. PMID 15993983 DOI: 10.1016/J.Peptides.2004.11.023 |
0.355 |
|
| 2005 |
Todorovic A, Holder JR, Bauzo RM, Scott JW, Kavanagh R, Abdel-Malek Z, Haskell-Luevano C. N-terminal fatty acylated His-dPhe-Arg-Trp-NH(2) tetrapeptides: influence of fatty acid chain length on potency and selectivity at the mouse melanocortin receptors and human melanocytes. Journal of Medicinal Chemistry. 48: 3328-36. PMID 15857138 DOI: 10.1021/Jm0490843 |
0.507 |
|
| 2005 |
Wilczynski A, Wilson KR, Scott JW, Edison AS, Haskell-Luevano C. Structure-activity relationships of the unique and potent agouti-related protein (AGRP)-melanocortin chimeric Tyr-c[beta-Asp-His-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 peptide template. Journal of Medicinal Chemistry. 48: 3060-75. PMID 15828845 DOI: 10.1021/jm049010r |
0.446 |
|
| 2005 |
Vaughan CH, Moore MC, Haskell-Luevano C, Rowland NE. Meal patterns and foraging in melanocortin receptor knockout mice. Physiology & Behavior. 84: 129-33. PMID 15642615 DOI: 10.1016/J.Physbeh.2004.10.016 |
0.362 |
|
| 2005 |
Sharov AA, Fessing M, Atoyan R, Sharova TY, Haskell-Luevano C, Weiner L, Funa K, Brissette JL, Gilchrest BA, Botchkarev VA. Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway. Proceedings of the National Academy of Sciences of the United States of America. 102: 93-8. PMID 15618398 DOI: 10.1073/Pnas.0408455102 |
0.324 |
|
| 2005 |
Irani BG, Xiang Z, Moore MC, Mandel RJ, Haskell-Luevano C. Voluntary exercise delays monogenetic obesity and overcomes reproductive dysfunction of the melanocortin-4 receptor knockout mouse. Biochemical and Biophysical Research Communications. 326: 638-44. PMID 15596147 DOI: 10.1016/J.Bbrc.2004.11.084 |
0.329 |
|
| 2004 |
Haskell-Luevano C, Todorovic A, Gridley K, Sorenson N, Irani B, Xiang Z. The melanocortin pathway: effects of voluntary exercise on the melanocortin-4 receptor knockout mice and ACTH(1-24) ligand structure activity relationships at the melanocortin-2 receptor. Endocrine Research. 30: 591-7. PMID 15666796 DOI: 10.1081/ERC-200043759 |
0.375 |
|
| 2004 |
Joseph CG, Wang XS, Scott JW, Bauzo RM, Xiang Z, Richards NG, Haskell-Luevano C. Stereochemical studies of the monocyclic agouti-related protein (103-122) Arg-Phe-Phe residues: conversion of a melanocortin-4 receptor antagonist into an agonist and results in the discovery of a potent and selective melanocortin-1 agonist. Journal of Medicinal Chemistry. 47: 6702-10. PMID 15615519 DOI: 10.1021/Jm0492756 |
0.568 |
|
| 2004 |
Irani BG, Holder JR, Todorovic A, Wilczynski AM, Joseph CG, Wilson KR, Haskell-Luevano C. Progress in the development of melanocortin receptor selective ligands. Current Pharmaceutical Design. 10: 3443-79. PMID 15579046 DOI: 10.2174/1381612043382891 |
0.493 |
|
| 2004 |
Wilczynski A, Wang XS, Bauzo RM, Xiang Z, Shaw AM, Millard WJ, Richards NG, Edison AS, Haskell-Luevano C. Structural characterization and pharmacology of a potent (Cys101-Cys119, Cys110-Cys117) bicyclic agouti-related protein (AGRP) melanocortin receptor antagonist. Journal of Medicinal Chemistry. 47: 5662-73. PMID 15509165 DOI: 10.1021/Jm049620R |
0.389 |
|
| 2004 |
Wilczynski A, Wang XS, Joseph CG, Xiang Z, Bauzo RM, Scott JW, Sorensen NB, Shaw AM, Millard WJ, Richards NG, Haskell-Luevano C. Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands. Journal of Medicinal Chemistry. 47: 2194-207. PMID 15084118 DOI: 10.1021/Jm0303608 |
0.576 |
|
| 2004 |
Todorovic A, Holder JR, Scott JW, Haskell-Luevano C. Synthesis and activity of the melanocortin Xaa-d-Phe-Arg-Trp-NH tetrapeptides with amide bond modifications. The Journal of Peptide Research : Official Journal of the American Peptide Society. 63: 270-8. PMID 15049839 DOI: 10.1111/J.1399-3011.2004.00137.X |
0.543 |
|
| 2004 |
Han G, Haskell-Luevano C, Kendall L, Bonner G, Hadley ME, Cone RD, Hruby VJ. De novo design, synthesis, and pharmacology of alpha-melanocyte stimulating hormone analogues derived from somatostatin by a hybrid approach. Journal of Medicinal Chemistry. 47: 1514-26. PMID 14998337 DOI: 10.1021/Jm030452X |
0.698 |
|
| 2004 |
Holder JR, Haskell-Luevano C. Melanocortin ligands: 30 years of structure-activity relationship (SAR) studies. Medicinal Research Reviews. 24: 325-56. PMID 14994367 DOI: 10.1002/Med.10064 |
0.494 |
|
| 2004 |
Abdel-Malek ZA, Kavanagh RJ, Koikov LN, Todorovic A, Haskell-Luevano C, McNulty JC, Jackson P, Milhauser G, Knittel JJ. Evaluation of the effects of 4-phenylbutyryl-his-d-phe-arg-trp-nh2 as a superpotent agonist of alpha-melanocortin on human melanocytes. Pigment Cell Research. 17: 449-450. DOI: 10.1111/J.1600-0749.2004.00175_72.X |
0.349 |
|
| 2003 |
Joseph CG, Wilczynski A, Holder JR, Xiang Z, Bauzo RM, Scott JW, Haskell-Luevano C. Chimeric NDP-MSH and MTII melanocortin peptides with agouti-related protein (AGRP) Arg-Phe-Phe amino acids possess agonist melanocortin receptor activity. Peptides. 24: 1899-908. PMID 15127941 DOI: 10.1016/J.Peptides.2003.10.005 |
0.58 |
|
| 2003 |
Holder JR, Bauzo RM, Xiang Z, Scott J, Haskell-Luevano C. Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence. Bioorganic & Medicinal Chemistry Letters. 13: 4505-9. PMID 14643357 DOI: 10.1016/J.Bmcl.2003.08.078 |
0.494 |
|
| 2003 |
Holder J, Haskell-Luevano C. Melanocortin tetrapeptides modified at the N-terminus, His, Phe, Arg, and Trp positions. Annals of the New York Academy of Sciences. 994: 36-48. PMID 12851296 |
0.457 |
|
| 2003 |
Joseph CG, Bauzo RM, Xiang Z, Haskell-Luevano C. Urea small molecule agonists on mouse melanocortin receptors. Bioorganic & Medicinal Chemistry Letters. 13: 2079-82. PMID 12781199 DOI: 10.1016/S0960-894X(03)00318-4 |
0.508 |
|
| 2003 |
Joseph CG, Bauzo RM, Xiang Z, Shaw AM, Millard WJ, Haskell-Luevano C. Elongation studies of the human agouti-related protein (AGRP) core decapeptide (Yc[CRFFNAFC]Y) results in antagonism at the mouse melanocortin-3 receptor. Peptides. 24: 263-70. PMID 12668211 DOI: 10.1016/S0196-9781(03)00030-5 |
0.513 |
|
| 2003 |
Holder JR, Marques FF, Xiang Z, Bauzo RM, Haskell-Luevano C. Characterization of aliphatic, cyclic, and aromatic N-terminally "capped" His-D-Phe-Arg-Trp-NH2 tetrapeptides at the melanocortin receptors. European Journal of Pharmacology. 462: 41-52. PMID 12591094 DOI: 10.1016/S0014-2999(03)01322-0 |
0.547 |
|
| 2003 |
Holder JR, Xiang Z, Bauzo RM, Haskell-Luevano C. Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 at the mouse melanocortin receptors. Part 3: modifications at the Arg position. Peptides. 24: 73-82. PMID 12576087 DOI: 10.1016/S0196-9781(02)00278-4 |
0.57 |
|
| 2002 |
Holder JR, Xiang Z, Bauzo RM, Haskell-Luevano C. Structure-activity relationships of the melanocortin tetrapeptide Ac-His-D-Phe-Arg-Trp-NH2 at the mouse melanocortin receptors. 4. Modifications at the Trp position. Journal of Medicinal Chemistry. 45: 5736-44. PMID 12477357 DOI: 10.1021/jm020296e |
0.493 |
|
| 2002 |
Bondebjerg J, Xiang Z, Bauzo RM, Haskell-Luevano C, Meldal M. A solid-phase approach to mouse melanocortin receptor agonists derived from a novel thioether cyclized peptidomimetic scaffold. Journal of the American Chemical Society. 124: 11046-55. PMID 12224952 DOI: 10.1021/Ja0123913 |
0.456 |
|
| 2002 |
Holder JR, Bauzo RM, Xiang Z, Haskell-Luevano C. Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors: part 2 modifications at the Phe position. Journal of Medicinal Chemistry. 45: 3073-81. PMID 12086493 DOI: 10.1021/jm010524p |
0.487 |
|
| 2002 |
Holder JR, Bauzo RM, Xiang Z, Haskell-Luevano C. Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors. 1. Modifications at the His position. Journal of Medicinal Chemistry. 45: 2801-10. PMID 12061882 DOI: 10.1021/Jm0104872 |
0.538 |
|
| 2001 |
Thirumoorthy R, Holder JR, Bauzo RM, Richards NG, Edison AS, Haskell-Luevano C. Novel agouti-related-protein-based melanocortin-1 receptor antagonist. Journal of Medicinal Chemistry. 44: 4114-24. PMID 11708914 DOI: 10.1021/Jm010215Z |
0.559 |
|
| 2001 |
Haskell-Luevano C, Holder JR, Monck EK, Bauzo RM. Characterization of melanocortin NDP-MSH agonist peptide fragments at the mouse central and peripheral melanocortin receptors. Journal of Medicinal Chemistry. 44: 2247-52. PMID 11405661 DOI: 10.1021/Jm010061N |
0.577 |
|
| 2001 |
Haskell-Luevano C, Cone RD, Monck EK, Wan YP. Structure activity studies of the melanocortin-4 receptor by in vitro mutagenesis: identification of agouti-related protein (AGRP), melanocortin agonist and synthetic peptide antagonist interaction determinants. Biochemistry. 40: 6164-79. PMID 11352754 DOI: 10.1021/Bi010025Q |
0.709 |
|
| 2001 |
Haskell-Luevano C, Monck EK. Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor. Regulatory Peptides. 99: 1-7. PMID 11257308 DOI: 10.1016/S0167-0115(01)00234-8 |
0.522 |
|
| 2000 |
Haskell-Luevano C, Monck EK, Wan YP, Schentrup AM. The agouti-related protein decapeptide (Yc[CRFFNAFC]Y) possesses agonist activity at the murine melanocortin-1 receptor. Peptides. 21: 683-9. PMID 10876051 DOI: 10.1016/S0196-9781(00)00194-7 |
0.452 |
|
| 2000 |
Haskell-Luevano C, Lim S, Yuan W, Cone RD, Hruby VJ. Structure activity studies of the melanocortin antagonist SHU9119 modified at the 6, 7, 8, and 9 positions. Peptides. 21: 49-57. PMID 10704719 DOI: 10.1016/S0196-9781(99)00167-9 |
0.718 |
|
| 1999 |
Hadley ME, Haskell-Luevano C. The proopiomelanocortin system. Annals of the New York Academy of Sciences. 885: 1-21. PMID 10816638 |
0.378 |
|
| 1999 |
Haskell-Luevano C, Rosenquist A, Souers A, Khong KC, Ellman JA, Cone RD. Compounds that activate the mouse melanocortin-1 receptor identified by screening a small molecule library based upon the beta-turn. Journal of Medicinal Chemistry. 42: 4380-7. PMID 10543881 DOI: 10.1021/Jm990190S |
0.601 |
|
| 1999 |
Chen P, Li C, Haskell-Luevano C, Cone RD, Smith MS. Altered expression of agouti-related protein and its colocalization with neuropeptide Y in the arcuate nucleus of the hypothalamus during lactation. Endocrinology. 140: 2645-50. PMID 10342854 DOI: 10.1210/Endo.140.6.6829 |
0.559 |
|
| 1999 |
Haskell-Luevano C, Chen P, Li C, Chang K, Smith MS, Cameron JL, Cone RD. Characterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat. Endocrinology. 140: 1408-15. PMID 10067869 DOI: 10.1210/Endo.140.3.6544 |
0.566 |
|
| 1999 |
Haskell-Luevano C, Hadley ME. The melanocortin receptors Drug News and Perspectives. 12: 197-205. |
0.367 |
|
| 1997 |
Yang Yk, Dickinson C, Haskell-Luevano C, Gantz I. Molecular basis for the interaction of [Nle4,D-Phe7]melanocyte stimulating hormone with the human melanocortin-1 receptor. The Journal of Biological Chemistry. 272: 23000-10. PMID 9287296 DOI: 10.1074/Jbc.272.37.23000 |
0.527 |
|
| 1997 |
Hruby VJ, Li G, Haskell-Luevano C, Shenderovich M. Design of peptides, proteins, and peptidomimetics in chi space. Biopolymers. 43: 219-66. PMID 9277134 DOI: 10.1002/(Sici)1097-0282(1997)43:3<219::Aid-Bip3>3.0.Co;2-Y |
0.517 |
|
| 1997 |
Haskell-Luevano C, Toth K, Boteju L, Job C, Castrucci AM, Hadley ME, Hruby VJ. beta-Methylation of the Phe7 and Trp9 melanotropin side chain pharmacophores affects ligand-receptor interactions and prolonged biological activity. Journal of Medicinal Chemistry. 40: 2740-9. PMID 9276019 DOI: 10.1021/Jm970018T |
0.493 |
|
| 1997 |
Haskell-Luevano C, Hendrata S, North C, Sawyer TK, Hadley ME, Hruby VJ, Dickinson C, Gantz I. Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R. Journal of Medicinal Chemistry. 40: 2133-9. PMID 9216831 DOI: 10.1021/Jm960840H |
0.627 |
|
| 1997 |
Haskell-Luevano C, Nikiforovich G, Sharma SD, Yang YK, Dickinson C, Hruby VJ, Gantz I. Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors. Journal of Medicinal Chemistry. 40: 1738-48. PMID 9171884 DOI: 10.1021/Jm960845E |
0.606 |
|
| 1996 |
Haskell-Luevano C, Sawyer TK, Trumpp-Kallmeyer S, Bikker JA, Humblet C, Gantz I, Hruby VJ. Three-dimensional molecular models of the hMC1R melanocortin receptor: complexes with melanotropin peptide agonists. Drug Design and Discovery. 14: 197-211. PMID 9017363 |
0.528 |
|
| 1996 |
Hadley ME, Hruby VJ, Jiang J, Sharma SD, Fink JL, Haskell-Luevano C, Bentley DL, al-Obeidi F, Sawyer TK. Melanocortin receptors: identification and characterization by melanotropic peptide agonists and antagonists. Pigment Cell Research / Sponsored by the European Society For Pigment Cell Research and the International Pigment Cell Society. 9: 213-34. PMID 9014208 DOI: 10.1111/J.1600-0749.1996.Tb00111.X |
0.581 |
|
| 1996 |
Haskell-Luevano C, Sawyer TK, Hendrata S, North C, Panahinia L, Stum M, Staples DJ, Castrucci AM, Hadley MF, Hruby VJ. Truncation studies of alpha-melanotropin peptides identify tripeptide analogues exhibiting prolonged agonist bioactivity. Peptides. 17: 995-1002. PMID 8899819 DOI: 10.1016/0196-9781(96)00141-6 |
0.544 |
|
| 1996 |
Boteju LW, Nikiforovich GV, Haskell-Luevano C, Fang SN, Zalewska T, Stropova D, Yamamura HI, Hruby VJ. The use of topographical constraints in receptor mapping: investigation of the topographical requirements of the tryptophan 30 residue for receptor binding of Asp-Tyr-D-Phe-Gly-Trp-(N-Me)Nle-Asp-Phe-NH2 (SNF 9007), a cholecystokinin (26-33) analogue that binds to both CCK-B and delta-opioid receptors. Journal of Medicinal Chemistry. 39: 4120-4. PMID 8831778 DOI: 10.1021/Jm960078J |
0.578 |
|
| 1996 |
Haskell-Luevano C, Miwa H, Dickinson C, Hadley ME, Hruby VJ, Yamada T, Gantz I. Characterizations of the unusual dissociation properties of melanotropin peptides from the melanocortin receptor, hMC1R. Journal of Medicinal Chemistry. 39: 432-5. PMID 8558511 DOI: 10.1021/Jm950407S |
0.521 |
|
| 1995 |
Haskell-Luevano C, Shenderovich MD, Sharma SD, Nikiforovich GV, Hadley ME, Hruby VJ. Design, synthesis, biology, and conformations of bicyclic alpha-melanotropin analogues. Journal of Medicinal Chemistry. 38: 1736-50. PMID 7752197 DOI: 10.1021/Jm00010A018 |
0.523 |
|
| 1995 |
Haskell-Luevano C, Boteju LW, Miwa H, Dickinson C, Gantz I, Yamada T, Hadley ME, Hruby VJ. Topographical modification of melanotropin peptide analogues with beta-methyltryptophan isomers at position 9 leads to differential potencies and prolonged biological activities. Journal of Medicinal Chemistry. 38: 4720-9. PMID 7473600 DOI: 10.1021/Jm00023A012 |
0.559 |
|
| 1995 |
Haskell-Luevano C, Boteju LW, Hruby VJ. Facile removal of the N-indole-mesitylenesulfonyl protecting group using HF cleavage conditions Letters in Peptide Science. 1: 163-170. DOI: 10.1007/Bf00117952 |
0.456 |
|
| 1994 |
Haskell-Luevano C, Miwa H, Dickinson C, Hruby VJ, Yamada T, Gantz I. Binding and cAMP studies of melanotropin peptides with the cloned human peripheral melanocortin receptor, hMC1R. Biochemical and Biophysical Research Communications. 204: 1137-42. PMID 7980588 DOI: 10.1006/Bbrc.1994.2581 |
0.401 |
|
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