| Year |
Citation |
Score |
| 2024 |
Todd JJ, Lawal TA, Chrismer IC, Kokkinis A, Grunseich C, Jain MS, Waite MR, Biancavilla V, Pocock S, Brooks K, Mendoza CJ, Norato G, Cheung K, Riekhof W, Varma P, ... ... Marks AR, et al. Rycal S48168 (ARM210) for -related myopathies: a phase one, open-label, dose-escalation trial. Eclinicalmedicine. 68: 102433. PMID 38318125 DOI: 10.1016/j.eclinm.2024.102433 |
0.307 |
|
| 2024 |
Souidi M, Resta J, Dridi H, Sleiman Y, Reiken S, Formoso K, Colombani S, Amédro P, Meyer P, Charrabi A, Vincenti M, Liu Y, Soni RK, Lezoualc'h F, Stéphane Blot DVM, ... ... Marks AR, et al. Ryanodine receptor dysfunction causes senescence and fibrosis in Duchenne dilated cardiomyopathy. Journal of Cachexia, Sarcopenia and Muscle. PMID 38221511 DOI: 10.1002/jcsm.13411 |
0.388 |
|
| 2023 |
Dridi H, Santulli G, Bahlouli L, Miotto MC, Weninger G, Marks AR. Mitochondrial Calcium Overload Plays a Causal Role in Oxidative Stress in the Failing Heart. Biomolecules. 13. PMID 37759809 DOI: 10.3390/biom13091409 |
0.304 |
|
| 2023 |
Dridi H, Liu Y, Reiken S, Liu X, Argyrousi EK, Yuan Q, Miotto MC, Sittenfeld L, Meddar A, Soni RK, Arancio O, Lacampagne A, Marks AR. Heart failure-induced cognitive dysfunction is mediated by intracellular Ca leak through ryanodine receptor type 2. Nature Neuroscience. PMID 37429912 DOI: 10.1038/s41593-023-01377-6 |
0.337 |
|
| 2023 |
Martuscello RT, Chen ML, Reiken S, Sittenfeld LR, Ruff DS, Ni CL, Lin CC, Pan MK, Louis ED, Marks AR, Kuo SH, Faust PL. Defective cerebellar ryanodine receptor type 1 and endoplasmic reticulum calcium 'leak' in tremor pathophysiology. Acta Neuropathologica. PMID 37335342 DOI: 10.1007/s00401-023-02602-z |
0.35 |
|
| 2023 |
Marks AR. Targeting ryanodine receptors to treat human diseases. The Journal of Clinical Investigation. 133. PMID 36647824 DOI: 10.1172/JCI162891 |
0.403 |
|
| 2022 |
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR. Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment. Science Advances. 8: eabo1272. PMID 35857850 DOI: 10.1126/sciadv.abo1272 |
0.342 |
|
| 2022 |
Melville Z, Dridi H, Yuan Q, Reiken S, Wronska A, Liu Y, Clarke OB, Marks AR. A drug and ATP binding site in type 1 ryanodine receptor. Structure (London, England : 1993). PMID 35580609 DOI: 10.1016/j.str.2022.04.010 |
0.385 |
|
| 2022 |
Dridi H, Forrester F, Umanskaya A, Xie W, Reiken S, Lacampagne A, Marks A. Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in . Elife. 11. PMID 35506650 DOI: 10.7554/eLife.75529 |
0.331 |
|
| 2022 |
Dridi H, Santulli G, Gambardella J, Jankauskas SS, Yuan Q, Yang J, Reiken S, Wang X, Wronska A, Liu X, Lacampagne A, Marks AR. IP3 receptor orchestrates maladaptive vascular responses in heart failure. The Journal of Clinical Investigation. 132. PMID 35166236 DOI: 10.1172/JCI152859 |
0.307 |
|
| 2021 |
Yuan Q, Dridi H, Clarke OB, Reiken S, Melville Z, Wronska A, Kushnir A, Zalk R, Sittenfeld L, Marks AR. RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation. Acta Neuropathologica Communications. 9: 186. PMID 34809703 DOI: 10.1186/s40478-021-01287-3 |
0.357 |
|
| 2021 |
Melville Z, Kim K, Clarke OB, Marks AR. High-resolution structure of the membrane-embedded skeletal muscle ryanodine receptor. Structure (London, England : 1993). PMID 34469755 DOI: 10.1016/j.str.2021.08.001 |
0.346 |
|
| 2021 |
Reiken S, Dridi H, Sittenfeld L, Liu X, Marks AR. Alzheimer's-like remodeling of neuronal ryanodine receptor in COVID-19. Biorxiv : the Preprint Server For Biology. PMID 33619477 DOI: 10.1101/2021.02.18.431811 |
0.35 |
|
| 2021 |
Dridi H, Wu W, Reiken SR, Ofer RM, Liu Y, Yuan Q, Sittenfeld L, Kushner J, Muchir A, Worman HJ, Marks AR. Ryanodine receptor remodeling in cardiomyopathy and muscular dystrophy caused by lamin A/C gene mutation. Human Molecular Genetics. PMID 33388782 DOI: 10.1093/hmg/ddaa278 |
0.407 |
|
| 2020 |
Dridi H, Kushnir A, Zalk R, Yuan Q, Melville Z, Marks AR. Reply to 'Mechanisms of ryanodine receptor 2 dysfunction in heart failure'. Nature Reviews. Cardiology. PMID 32901149 DOI: 10.1038/S41569-020-00444-W |
0.369 |
|
| 2020 |
Dridi H, Liu X, Yuan Q, Reiken S, Mohamad Y, Sittenfeld LR, Apostolou P, Buron J, Sicard P, Matecki S, Thireau J, Menuet C, Lacampagne A, Marks AR. Role of defective calcium regulation in cardiorespiratory dysfunction in Huntington's disease. Jci Insight. PMID 32897880 DOI: 10.1172/Jci.Insight.140614 |
0.46 |
|
| 2020 |
Dridi H, Kushnir A, Zalk R, Yuan Q, Melville Z, Marks AR. Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target. Nature Reviews. Cardiology. PMID 32555383 DOI: 10.1038/S41569-020-0394-8 |
0.502 |
|
| 2020 |
Kushnir A, Todd JJ, Witherspoon JW, Yuan Q, Reiken S, Lin H, Munce RH, Wajsberg B, Melville Z, Clarke OB, Wedderburn-Pugh K, Wronska A, Razaqyar MS, Chrismer IC, Shelton MO, ... ... Marks AR, et al. Intracellular calcium leak as a therapeutic target for RYR1-related myopathies. Acta Neuropathologica. PMID 32236737 DOI: 10.1007/S00401-020-02150-W |
0.42 |
|
| 2019 |
Dridi H, Yehya M, Barsotti R, Reiken S, Angebault C, Jung B, Jaber S, Marks AR, Lacampagne A, Matecki S. Mitochondrial oxidative stress induces leaky ryanodine receptor during mechanical ventilation. Free Radical Biology & Medicine. PMID 31756525 DOI: 10.1016/J.Freeradbiomed.2019.11.019 |
0.372 |
|
| 2019 |
Joseph LC, Avula UMR, Wan EY, Reyes MV, Lakkadi KR, Subramanyam P, Nakanishi K, Homma S, Muchir A, Pajvani UB, Thorp EB, Reiken SR, Marks AR, Colecraft HM, Morrow JP. Dietary Saturated Fat Promotes Arrhythmia by Activating NOX2 (NADPH Oxidase 2). Circulation. Arrhythmia and Electrophysiology. 12: e007573. PMID 31665913 DOI: 10.1161/Circep.119.007573 |
0.316 |
|
| 2018 |
Acimovic I, Refaat MM, Moreau A, Salykin A, Reiken S, Sleiman Y, Souidi M, Přibyl J, Kajava AV, Richard S, Lu JT, Chevalier P, Skládal P, Dvořak P, Rotrekl V, ... Marks AR, et al. Post-Translational Modifications and Diastolic Calcium Leak Associated to the Novel RyR2-D3638A Mutation Lead to CPVT in Patient-Specific hiPSC-Derived Cardiomyocytes. Journal of Clinical Medicine. 7. PMID 30413023 DOI: 10.3390/Jcm7110423 |
0.365 |
|
| 2018 |
Kushnir A, Wajsberg B, Marks AR. Ryanodine receptor dysfunction in human disorders. Biochimica Et Biophysica Acta. 1865: 1687-1697. PMID 30040966 DOI: 10.1016/J.Bbamcr.2018.07.011 |
0.5 |
|
| 2018 |
Kushnir A, Santulli G, Reiken SR, Coromilas E, Godfrey SJ, Brunjes DL, Colombo PC, Yuzefpolskaya M, Sokol SI, Kitsis RN, Marks AR. Ryanodine Receptor Calcium Leak in Circulating B-Lymphocytes as a Biomarker in Heart Failure. Circulation. PMID 29593014 DOI: 10.1161/Circulationaha.117.032703 |
0.47 |
|
| 2018 |
Santulli G, Lewis D, des Georges A, Marks AR, Frank J. Ryanodine Receptor Structure and Function in Health and Disease. Sub-Cellular Biochemistry. 87: 329-352. PMID 29464565 DOI: 10.1007/978-981-10-7757-9_11 |
0.465 |
|
| 2018 |
Hartel AJW, Ong P, Schroeder I, Giese MH, Shekar S, Clarke OB, Zalk R, Marks AR, Hendrickson WA, Shepard KL. Single-channel recordings of RyR1 at microsecond resolution in CMOS-suspended membranes. Proceedings of the National Academy of Sciences of the United States of America. PMID 29432144 DOI: 10.1073/Pnas.1712313115 |
0.394 |
|
| 2017 |
Regan JN, Mikesell C, Reiken S, Xu H, Marks AR, Mohammad KS, Guise TA, Waning DL. Osteolytic Breast Cancer Causes Skeletal Muscle Weakness in an Immunocompetent Syngeneic Mouse Model. Frontiers in Endocrinology. 8: 358. PMID 29312148 DOI: 10.3389/Fendo.2017.00358 |
0.356 |
|
| 2017 |
Santulli G, Lewis DR, Marks AR. Physiology and pathophysiology of excitation-contraction coupling: the functional role of ryanodine receptor. Journal of Muscle Research and Cell Motility. PMID 28653141 DOI: 10.1007/S10974-017-9470-Z |
0.468 |
|
| 2017 |
Lacampagne A, Liu X, Reiken S, Bussiere R, Meli AC, Lauritzen I, Teich AF, Zalk R, Saint N, Arancio O, Bauer C, Duprat F, Briggs CA, Chakroborty S, Stutzmann GE, ... ... Marks AR, et al. Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits. Acta Neuropathologica. PMID 28631094 DOI: 10.1007/S00401-017-1733-7 |
0.406 |
|
| 2017 |
Su M, Gao F, Yuan Q, Mao Y, Li DL, Guo Y, Yang C, Wang XH, Bruni R, Kloss B, Zhao H, Zeng Y, Zhang FB, Marks AR, Hendrickson WA, et al. Structural basis for conductance through TRIC cation channels. Nature Communications. 8: 15103. PMID 28524849 DOI: 10.1038/Ncomms15103 |
0.366 |
|
| 2017 |
Zalk R, Marks AR. Ca(2+) Release Channels Join the 'Resolution Revolution'. Trends in Biochemical Sciences. 42: 543-555. PMID 28499500 DOI: 10.1016/J.Tibs.2017.04.005 |
0.497 |
|
| 2017 |
Bussiere R, Lacampagne A, Reiken S, Liu X, Scheuerman V, Zalk R, Martin C, Checler F, Marks AR, Chami M. Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor. The Journal of Biological Chemistry. PMID 28476886 DOI: 10.1074/Jbc.M116.743070 |
0.398 |
|
| 2017 |
Santulli G, Nakashima R, Yuan Q, Marks AR. Intracellular calcium release channels: an update. The Journal of Physiology. PMID 28303572 DOI: 10.1113/Jp272781 |
0.49 |
|
| 2017 |
Hartel AJ, Ong P, Schroeder I, Clarke O, Shekar S, Giese HM, Marks AR, Hendrickson WA, Shepard KL. Sub-Microsecond-Scale Dynamics in the Type-1 Ryanodine Receptor Observed with CMOS-Integrated Electrophysiology Biophysical Journal. 112: 134a. DOI: 10.1016/J.Bpj.2016.11.742 |
0.356 |
|
| 2017 |
Santulli G, Gambardella J, Reiken S, Yuan Q, Nakashima R, Forrester FM, Lacampagne A, Marks A. Mechanistic Role of Type 1 Inositol 1,4,5-Trisphosphate Receptor in the Regulation of Vascular Tone in Heart Failure Biophysical Journal. 112: 482a. DOI: 10.1016/J.Bpj.2016.11.2610 |
0.37 |
|
| 2017 |
Georges Ad, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank J. Functional Study of the Ryanodine Receptor Type 1 using Cryo-Electron Microscopy Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.1813 |
0.433 |
|
| 2017 |
Forrester FM, Umanskaya A, Xie W, Reiken S, Yuan Q, Lacampagne A, Marks A. The Role of Calcium Leak in Age-Dependent Loss of C. Elegans Muscle Function Biophysical Journal. 112: 232a. DOI: 10.1016/J.Bpj.2016.11.1274 |
0.42 |
|
| 2016 |
des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank J. Structural Basis for Gating and Activation of RyR1. Cell. 167: 145-157.e17. PMID 27662087 DOI: 10.1016/J.Cell.2016.08.075 |
0.429 |
|
| 2016 |
Matecki S, Dridi H, Jung B, Saint N, Reiken SR, Scheuermann V, Mrozek S, Santulli G, Umanskaya A, Petrof BJ, Jaber S, Marks AR, Lacampagne A. Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27457930 DOI: 10.1073/Pnas.1609707113 |
0.457 |
|
| 2016 |
Yuan Q, Yang J, Santulli G, Reiken SR, Wronska A, Kim MM, Osborne BW, Lacampagne A, Yin Y, Marks AR. Maintenance of normal blood pressure is dependent on IP3R1-mediated regulation of eNOS. Proceedings of the National Academy of Sciences of the United States of America. PMID 27402766 DOI: 10.1073/Pnas.1608859113 |
0.404 |
|
| 2015 |
Santulli G, Pagano G, Sardu C, Xie W, Reiken S, D'Ascia SL, Cannone M, Marziliano N, Trimarco B, Guise TA, Lacampagne A, Marks AR. Calcium release channel RyR2 regulates insulin release and glucose homeostasis. The Journal of Clinical Investigation. 125: 4316. PMID 26524594 DOI: 10.1172/Jci84937 |
0.345 |
|
| 2015 |
Waning DL, Mohammad KS, Reiken S, Xie W, Andersson DC, John S, Chiechi A, Wright LE, Umanskaya A, Niewolna M, Trivedi T, Charkhzarrin S, Khatiwada P, Wronska A, Haynes A, ... ... Marks AR, et al. Excess TGF-β mediates muscle weakness associated with bone metastases in mice. Nature Medicine. PMID 26457758 DOI: 10.1038/Nm.3961 |
0.354 |
|
| 2015 |
Santulli G, Xie W, Reiken SR, Marks AR. Mitochondrial calcium overload is a key determinant in heart failure. Proceedings of the National Academy of Sciences of the United States of America. PMID 26217001 DOI: 10.1073/Pnas.1513047112 |
0.349 |
|
| 2015 |
Santulli G, Marks AR. Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging. Current Molecular Pharmacology. 8: 206-22. PMID 25966694 DOI: 10.2174/1874467208666150507105105 |
0.503 |
|
| 2015 |
Santulli G, Pagano G, Sardu C, Xie W, Reiken S, D'Ascia SL, Cannone M, Marziliano N, Trimarco B, Guise TA, Lacampagne A, Marks AR. Calcium release channel RyR2 regulates insulin release and glucose homeostasis. The Journal of Clinical Investigation. 125: 1968-78. PMID 25844899 DOI: 10.1172/Jci79273 |
0.425 |
|
| 2015 |
Zalk R, Clarke OB, des Georges A, Grassucci RA, Reiken S, Mancia F, Hendrickson WA, Frank J, Marks AR. Structure of a mammalian ryanodine receptor. Nature. 517: 44-9. PMID 25470061 DOI: 10.1038/Nature13950 |
0.454 |
|
| 2015 |
Cheung JW, Meli AC, Xie W, Mittal S, Reiken S, Wronska A, Xu L, Steinberg JS, Markowitz SM, Iwai S, Lacampagne A, Lerman BB, Marks AR. Short-coupled polymorphic ventricular tachycardia at rest linked to a novel ryanodine receptor (RyR2) mutation: leaky RyR2 channels under non-stress conditions. International Journal of Cardiology. 180: 228-36. PMID 25463374 DOI: 10.1016/J.Ijcard.2014.11.119 |
0.349 |
|
| 2014 |
Umanskaya A, Santulli G, Xie W, Andersson DC, Reiken SR, Marks AR. Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging. Proceedings of the National Academy of Sciences of the United States of America. 111: 15250-5. PMID 25288763 DOI: 10.1073/Pnas.1412754111 |
0.419 |
|
| 2014 |
Umanskaya A, Andersson D, Xie W, Reiken S, Marks AR. C. Elegans as a Model to Study Ryanodine Receptor Function in Aging Biophysical Journal. 106: 111. DOI: 10.1016/J.Bpj.2013.11.677 |
0.4 |
|
| 2013 |
Xie W, Santulli G, Guo X, Gao M, Chen BX, Marks AR. Imaging atrial arrhythmic intracellular calcium in intact heart. Journal of Molecular and Cellular Cardiology. 64: 120-3. PMID 24041536 DOI: 10.1016/J.Yjmcc.2013.09.003 |
0.408 |
|
| 2013 |
Subramanyam P, Chang DD, Fang K, Xie W, Marks AR, Colecraft HM. Manipulating L-type calcium channels in cardiomyocytes using split-intein protein transsplicing. Proceedings of the National Academy of Sciences of the United States of America. 110: 15461-6. PMID 24003157 DOI: 10.1073/Pnas.1308161110 |
0.427 |
|
| 2013 |
Goldklang MP, Perez-Zoghbi JF, Trischler J, Nkyimbeng T, Zakharov SI, Shiomi T, Zelonina T, Marks AR, D'Armiento JM, Marx SO. Treatment of experimental asthma using a single small molecule with anti-inflammatory and BK channel-activating properties. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 4975-86. PMID 23995289 DOI: 10.1096/Fj.13-235176 |
0.313 |
|
| 2013 |
Rullman E, Andersson DC, Melin M, Reiken S, Mancini DM, Marks AR, Lund LH, Gustafsson T. Modifications of skeletal muscle ryanodine receptor type 1 and exercise intolerance in heart failure. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 32: 925-9. PMID 23953820 DOI: 10.1016/J.Healun.2013.06.026 |
0.414 |
|
| 2013 |
Andersson DC, Betzenhauser MJ, Reiken S, Umanskaya A, Shiomi T, Marks AR. Reply from Daniel C. Andersson, Matthew J. Betzenhauser, Steven Reiken, Alisa Umanskaya, Takayuki Shiomi and Andrew R. Marks. The Journal of Physiology. 591: 3103. PMID 23774683 DOI: 10.1113/Jphysiol.2013.255554 |
0.328 |
|
| 2013 |
Marx SO, Marks AR. Dysfunctional ryanodine receptors in the heart: New insights into complex cardiovascular diseases Journal of Molecular and Cellular Cardiology. 58: 225-231. PMID 23507255 DOI: 10.1016/J.Yjmcc.2013.03.005 |
0.507 |
|
| 2013 |
Marks AR. Calcium cycling proteins and heart failure: mechanisms and therapeutics. The Journal of Clinical Investigation. 123: 46-52. PMID 23281409 DOI: 10.1172/Jci62834 |
0.489 |
|
| 2012 |
Kushnir A, Marks AR. Ryanodine receptor patents. Recent Patents On Biotechnology. 6: 157-66. PMID 23092431 DOI: 10.2174/1872208311206030157 |
0.468 |
|
| 2012 |
Andersson DC, Betzenhauser MJ, Reiken S, Umanskaya A, Shiomi T, Marks AR. Stress-induced increase in skeletal muscle force requires protein kinase A phosphorylation of the ryanodine receptor. The Journal of Physiology. 590: 6381-7. PMID 23070698 DOI: 10.1113/Jphysiol.2012.237925 |
0.426 |
|
| 2012 |
Liu X, Betzenhauser MJ, Reiken S, Meli AC, Xie W, Chen BX, Arancio O, Marks AR. Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction. Cell. 150: 1055-67. PMID 22939628 DOI: 10.1016/J.Cell.2012.06.052 |
0.402 |
|
| 2012 |
Shan J, Xie W, Betzenhauser M, Reiken S, Chen BX, Wronska A, Marks AR. Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia. Circulation Research. 111: 708-17. PMID 22828895 DOI: 10.1161/Circresaha.112.273342 |
0.473 |
|
| 2012 |
Andersson DC, Meli AC, Reiken S, Betzenhauser MJ, Umanskaya A, Shiomi T, D'Armiento J, Marks AR. Leaky ryanodine receptors in β-sarcoglycan deficient mice: a potential common defect in muscular dystrophy. Skeletal Muscle. 2: 9. PMID 22640601 DOI: 10.1186/2044-5040-2-9 |
0.447 |
|
| 2012 |
Goonasekera SA, Hammer K, Auger-Messier M, Bodi I, Chen X, Zhang H, Reiken S, Elrod JW, Correll RN, York AJ, Sargent MA, Hofmann F, Moosmang S, Marks AR, Houser SR, et al. Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice. The Journal of Clinical Investigation. 122: 280-90. PMID 22133878 DOI: 10.1172/Jci58227 |
0.428 |
|
| 2012 |
Sassi Y, Abi-Gerges A, Fauconnier J, Mougenot N, Reiken S, Haghighi K, Kranias EG, Marks AR, Lacampagne A, Engelhardt S, Hatem SN, Lompre AM, Hulot JS. Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 1009-17. PMID 22090316 DOI: 10.1096/Fj.11-194027 |
0.362 |
|
| 2012 |
Andersson DC, Betzenhauser MJ, Marks AR. Excitation-contraction coupling in the heart Muscle. 1: 153-159. DOI: 10.1016/B978-0-12-381510-1.00012-0 |
0.436 |
|
| 2011 |
Andersson DC, Betzenhauser MJ, Reiken S, Meli AC, Umanskaya A, Xie W, Shiomi T, Zalk R, Lacampagne A, Marks AR. Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging. Cell Metabolism. 14: 196-207. PMID 21803290 DOI: 10.1016/J.Cmet.2011.05.014 |
0.445 |
|
| 2011 |
Fauconnier J, Meli AC, Thireau J, Roberge S, Shan J, Sassi Y, Reiken SR, Rauzier JM, Marchand A, Chauvier D, Cassan C, Crozier C, Bideaux P, Lompré AM, Jacotot E, ... Marks AR, et al. Ryanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia-reperfusion. Proceedings of the National Academy of Sciences of the United States of America. 108: 13258-63. PMID 21788490 DOI: 10.1073/Pnas.1100286108 |
0.41 |
|
| 2011 |
Meli AC, Refaat MM, Dura M, Reiken S, Wronska A, Wojciak J, Carroll J, Scheinman MM, Marks AR. A novel ryanodine receptor mutation linked to sudden death increases sensitivity to cytosolic calcium. Circulation Research. 109: 281-90. PMID 21659649 DOI: 10.1161/Circresaha.111.244970 |
0.372 |
|
| 2011 |
Betzenhauser MJ, Andersson DC, Reiken S, Marks AR. The Role of Ryanodine Receptor Phosphorylation in Skeletal Muscle Excitation-Contraction Coupling Biophysical Journal. 100: 592a. DOI: 10.1016/J.Bpj.2010.12.3414 |
0.433 |
|
| 2011 |
Meli AC, Reiken S, Zalk R, Andersson DC, Betzenhauser MJ, Marks AR. Altered Ca2+ Sensitivity and Gating Properties of Skeletal Muscle Ryanodine Receptors in Aged Mice Biophysical Journal. 100: 417a. DOI: 10.1016/J.Bpj.2010.12.2469 |
0.465 |
|
| 2011 |
Andersson DC, Betzenhauser MJ, Reiken S, Meli AC, Xie W, Lacampagne A, Marks AR. Preventing Ryanodine Receptor 1 calcium Leak Improves Age-Dependent Muscle Dysfunction Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.1775 |
0.436 |
|
| 2010 |
Andersson DC, Marks AR. Fixing ryanodine receptor Ca leak - a novel therapeutic strategy for contractile failure in heart and skeletal muscle. Drug Discovery Today. Disease Mechanisms. 7: e151-e157. PMID 21113427 DOI: 10.1016/J.Ddmec.2010.09.009 |
0.518 |
|
| 2010 |
Shan J, Kushnir A, Betzenhauser MJ, Reiken S, Li J, Lehnart SE, Lindegger N, Mongillo M, Mohler PJ, Marks AR. Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice. The Journal of Clinical Investigation. 120: 4388-98. PMID 21099118 DOI: 10.1172/Jci32726 |
0.505 |
|
| 2010 |
Shan J, Betzenhauser MJ, Kushnir A, Reiken S, Meli AC, Wronska A, Dura M, Chen BX, Marks AR. Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice. The Journal of Clinical Investigation. 120: 4375-87. PMID 21099115 DOI: 10.1172/Jci37649 |
0.475 |
|
| 2010 |
Kushnir A, Marks AR. The ryanodine receptor in cardiac physiology and disease. Advances in Pharmacology (San Diego, Calif.). 59: 1-30. PMID 20933197 DOI: 10.1016/S1054-3589(10)59001-X |
0.448 |
|
| 2010 |
Sampson KJ, Iyer V, Marks AR, Kass RS. A computational model of Purkinje fibre single cell electrophysiology: implications for the long QT syndrome. The Journal of Physiology. 588: 2643-55. PMID 20498233 DOI: 10.1113/Jphysiol.2010.187328 |
0.39 |
|
| 2010 |
Kushnir A, Shan J, Betzenhauser MJ, Reiken S, Marks AR. Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure. Proceedings of the National Academy of Sciences of the United States of America. 107: 10274-9. PMID 20479242 DOI: 10.1073/Pnas.1005843107 |
0.457 |
|
| 2010 |
Kushnir A, Betzenhauser MJ, Marks AR. Ryanodine receptor studies using genetically engineered mice. Febs Letters. 584: 1956-65. PMID 20214899 DOI: 10.1016/J.Febslet.2010.03.005 |
0.438 |
|
| 2010 |
Betzenhauser MJ, Marks AR. Ryanodine receptor channelopathies. PflüGers Archiv : European Journal of Physiology. 460: 467-80. PMID 20179962 DOI: 10.1007/S00424-010-0794-4 |
0.498 |
|
| 2010 |
Lompré AM, Hajjar RJ, Harding SE, Kranias EG, Lohse MJ, Marks AR. Ca2+ cycling and new therapeutic approaches for heart failure. Circulation. 121: 822-30. PMID 20124124 DOI: 10.1161/Circulationaha.109.890954 |
0.445 |
|
| 2010 |
Fauconnier J, Thireau J, Reiken S, Cassan C, Richard S, Matecki S, Marks AR, Lacampagne A. Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy. Proceedings of the National Academy of Sciences of the United States of America. 107: 1559-64. PMID 20080623 DOI: 10.1073/Pnas.0908540107 |
0.504 |
|
| 2010 |
Kushnir A, Shan J, Betzenhauser MJ, Reiken S, Marks AR. Reply to Eisner et al.: CaMKII phosphorylation of RyR2 increases cardiac contractility Proceedings of the National Academy of Sciences of the United States of America. 107. DOI: 10.1073/Pnas.1009086107 |
0.508 |
|
| 2010 |
Fauconnier J, Thireau J, Reiken S, Cassan C, Richard S, Matecki S, Marks AR, Lacampagne A. Defective RYR2 Channels Trigger Ventricular Arrhythmias in Duchenne Muscular Dystrophy Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.1072 |
0.516 |
|
| 2009 |
Lindegger N, Hagen BM, Marks AR, Lederer WJ, Kass RS. Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazine. Journal of Molecular and Cellular Cardiology. 47: 326-34. PMID 19371746 DOI: 10.1016/J.Yjmcc.2009.04.003 |
0.428 |
|
| 2009 |
Bellinger AM, Reiken S, Carlson C, Mongillo M, Liu X, Rothman L, Matecki S, Lacampagne A, Marks AR. Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle. Nature Medicine. 15: 325-30. PMID 19198614 DOI: 10.1038/Nm.1916 |
0.492 |
|
| 2009 |
Shan J, Reiken S, Dura M, Meli A, Mongillo M, Marks AR. Role of the Ryanodine Receptor/Calcium Release Channel in Beta-adrenergic Receptor Blocker Treatment of Heart Failure Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.506 |
0.446 |
|
| 2009 |
Meli AC, Zalk R, Wronska A, Karlin A, Marks AR. Mapping the Ryanodine Receptors Pore Region Using the Substituted Cysteine Accessibility Method Biophysical Journal. 96: 106a. DOI: 10.1016/J.Bpj.2008.12.460 |
0.441 |
|
| 2008 |
Aydin J, Shabalina IG, Place N, Reiken S, Zhang SJ, Bellinger AM, Nedergaard J, Cannon B, Marks AR, Bruton JD, Westerblad H. Nonshivering thermogenesis protects against defective calcium handling in muscle. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3919-24. PMID 18687806 DOI: 10.1096/Fj.08-113712 |
0.407 |
|
| 2008 |
Lehnart SE, Mongillo M, Bellinger A, Lindegger N, Chen BX, Hsueh W, Reiken S, Wronska A, Drew LJ, Ward CW, Lederer WJ, Kass RS, Morley G, Marks AR. Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice. The Journal of Clinical Investigation. 118: 2230-45. PMID 18483626 DOI: 10.1172/Jci35346 |
0.453 |
|
| 2008 |
Bellinger AM, Reiken S, Dura M, Murphy PW, Deng SX, Landry DW, Nieman D, Lehnart SE, Samaru M, LaCampagne A, Marks AR. Remodeling of ryanodine receptor complex causes "leaky" channels: A molecular mechanism for decreased exercise capacity Proceedings of the National Academy of Sciences of the United States of America. 105: 2198-2202. PMID 18268335 DOI: 10.1073/Pnas.0711074105 |
0.437 |
|
| 2008 |
Bellinger AM, Mongillo M, Marks AR. Stressed out: the skeletal muscle ryanodine receptor as a target of stress. The Journal of Clinical Investigation. 118: 445-53. PMID 18246195 DOI: 10.1172/Jci34006 |
0.447 |
|
| 2007 |
deSouza N, Cui J, Dura M, McDonald TV, Marks AR. A function for tyrosine phosphorylation of type 1 inositol 1,4,5-trisphosphate receptor in lymphocyte activation. The Journal of Cell Biology. 179: 923-34. PMID 18056410 DOI: 10.1083/Jcb.200708200 |
0.442 |
|
| 2007 |
Lehnart SE, Ackerman MJ, Benson DW, Brugada R, Clancy CE, Donahue JK, George AL, Grant AO, Groft SC, January CT, Lathrop DA, Lederer WJ, Makielski JC, Mohler PJ, Moss A, ... ... Marks AR, et al. Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function. Circulation. 116: 2325-45. PMID 17998470 DOI: 10.1161/Circulationaha.107.711689 |
0.371 |
|
| 2007 |
Lehnart S, Marks AR. Regulation of ryanodine receptors in the heart. Circulation Research. 101: 746-9. PMID 17932330 DOI: 10.1161/Circresaha.107.162479 |
0.487 |
|
| 2007 |
Tester DJ, Dura M, Carturan E, Reiken S, Wronska A, Marks AR, Ackerman MJ. A mechanism for sudden infant death syndrome (SIDS): stress-induced leak via ryanodine receptors. Heart Rhythm. 4: 733-9. PMID 17556193 DOI: 10.1016/J.Hrthm.2007.02.026 |
0.304 |
|
| 2007 |
Zalk R, Lehnart SE, Marks AR. Modulation of the ryanodine receptor and intracellular calcium. Annual Review of Biochemistry. 76: 367-85. PMID 17506640 DOI: 10.1146/Annurev.Biochem.76.053105.094237 |
0.494 |
|
| 2007 |
Mongillo M, Marks AR. Models of heart failure progression: Ca2+ dysregulation Drug Discovery Today: Disease Models. 4: 191-196. DOI: 10.1016/J.Ddmod.2007.06.005 |
0.395 |
|
| 2006 |
Marks AR. Novel therapy for heart failure and exercise-induced ventricular tachycardia based on 'fixing' the leak in ryanodine receptors Novartis Foundation Symposium. 274: 132-147. PMID 17019810 DOI: 10.1002/0470029331.Ch9 |
0.519 |
|
| 2006 |
Lehnart SE, Marks AR. Phosphodiesterase 4D and heart failure: a cautionary tale. Expert Opinion On Therapeutic Targets. 10: 677-88. PMID 16981825 DOI: 10.1517/14728222.10.5.677 |
0.425 |
|
| 2006 |
Lehnart SE, Terrenoire C, Reiken S, Wehrens XH, Song LS, Tillman EJ, Mancarella S, Coromilas J, Lederer WJ, Kass RS, Marks AR. Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proceedings of the National Academy of Sciences of the United States of America. 103: 7906-10. PMID 16672364 DOI: 10.1073/Pnas.0602133103 |
0.497 |
|
| 2006 |
Huang F, Shan J, Reiken S, Wehrens XH, Marks AR. Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 3456-61. PMID 16481613 DOI: 10.1073/Pnas.0511282103 |
0.518 |
|
| 2006 |
Wehrens XH, Lehnart SE, Reiken S, Vest JA, Wronska A, Marks AR. Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proceedings of the National Academy of Sciences of the United States of America. 103: 511-8. PMID 16407108 DOI: 10.1073/Pnas.0510113103 |
0.5 |
|
| 2005 |
Lehnart SE, Wehrens XH, Reiken S, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SL, Conti M, Marks AR. Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell. 123: 25-35. PMID 16213210 DOI: 10.1016/J.Cell.2005.07.030 |
0.482 |
|
| 2005 |
Wehrens XH, Lehnart SE, Marks AR. Ryanodine receptor-targeted anti-arrhythmic therapy. Annals of the New York Academy of Sciences. 1047: 366-75. PMID 16093511 DOI: 10.1196/Annals.1341.032 |
0.504 |
|
| 2005 |
Lehnart SE, Wehrens XH, Marks AR. Defective ryanodine receptor interdomain interactions may contribute to intracellular Ca2+ leak: a novel therapeutic target in heart failure. Circulation. 111: 3342-6. PMID 15983258 DOI: 10.1161/Circulationaha.105.551861 |
0.455 |
|
| 2005 |
Wehrens XH, Lehnart SE, Reiken S, van der Nagel R, Morales R, Sun J, Cheng Z, Deng SX, de Windt LJ, Landry DW, Marks AR. Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proceedings of the National Academy of Sciences of the United States of America. 102: 9607-12. PMID 15972811 DOI: 10.1073/Pnas.0500353102 |
0.461 |
|
| 2005 |
Vest JA, Wehrens XH, Reiken SR, Lehnart SE, Dobrev D, Chandra P, Danilo P, Ravens U, Rosen MR, Marks AR. Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation. 111: 2025-32. PMID 15851612 DOI: 10.1161/01.Cir.0000162461.67140.4C |
0.463 |
|
| 2005 |
Klotz S, Barbone A, Reiken S, Holmes JW, Naka Y, Oz MC, Marks AR, Burkhoff D. Left ventricular assist device support normalizes left and right ventricular beta-adrenergic pathway properties. Journal of the American College of Cardiology. 45: 668-76. PMID 15734609 DOI: 10.1016/J.Jacc.2004.11.042 |
0.313 |
|
| 2005 |
Wehrens XH, Lehnart SE, Marks AR. Intracellular calcium release and cardiac disease. Annual Review of Physiology. 67: 69-98. PMID 15709953 DOI: 10.1146/Annurev.Physiol.67.040403.114521 |
0.515 |
|
| 2005 |
Rodrigue-Way A, Burkhoff D, Geesaman BJ, Golden S, Xu J, Pollman MJ, Donoghue M, Jeyaseelan R, Houser S, Breitbart RE, Marks A, Acton S. Sarcomeric genes involved in reverse remodeling of the heart during left ventricular assist device support. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 24: 73-80. PMID 15653383 DOI: 10.1016/J.Healun.2003.10.016 |
0.352 |
|
| 2005 |
Lehnart SE, Wehrens XHT, Marks AR. Ryanodine receptors as drug targets for heart failure and cardiac arrhythmias Drug Discovery Today: Therapeutic Strategies. 2: 259-269. DOI: 10.1016/J.Ddstr.2005.08.011 |
0.505 |
|
| 2005 |
Marks AR. Enhancing Calstabin Binding to Ryanodine Receptors Improves Both Cardiac and Skeletal Muscle Function in Heart Failure Journal of Cardiac Failure. 11: S231. DOI: 10.1016/J.Cardfail.2005.08.008 |
0.419 |
|
| 2004 |
Wehrens XH, Marks AR. Sudden unexplained death caused by cardiac ryanodine receptor (RyR2) mutations. Mayo Clinic Proceedings. 79: 1367-71. PMID 15544013 DOI: 10.4065/79.11.1367 |
0.385 |
|
| 2004 |
Lehnart SE, Wehrens XH, Marks AR. Calstabin deficiency, ryanodine receptors, and sudden cardiac death. Biochemical and Biophysical Research Communications. 322: 1267-79. PMID 15336974 DOI: 10.1016/J.Bbrc.2004.08.032 |
0.529 |
|
| 2004 |
Wehrens XH, Marks AR. Novel therapeutic approaches for heart failure by normalizing calcium cycling. Nature Reviews. Drug Discovery. 3: 565-73. PMID 15232578 DOI: 10.1038/Nrd1440 |
0.49 |
|
| 2004 |
Lehnart SE, Wehrens XH, Kushnir A, Marks AR. Cardiac ryanodine receptor function and regulation in heart disease. Annals of the New York Academy of Sciences. 1015: 144-59. PMID 15201156 DOI: 10.1196/Annals.1302.012 |
0.511 |
|
| 2004 |
Lehnart SE, Wehrens XH, Laitinen PJ, Reiken SR, Deng SX, Cheng Z, Landry DW, Kontula K, Swan H, Marks AR. Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation. 109: 3208-14. PMID 15197150 DOI: 10.1161/01.Cir.0000132472.98675.Ec |
0.468 |
|
| 2004 |
Wehrens XH, Marks AR. Molecular determinants of altered contractility in heart failure. Annals of Medicine. 36: 70-80. PMID 15176427 DOI: 10.1080/17431380410032481 |
0.468 |
|
| 2004 |
Wehrens XH, Lehnart SE, Reiken SR, Deng SX, Vest JA, Cervantes D, Coromilas J, Landry DW, Marks AR. Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science (New York, N.Y.). 304: 292-6. PMID 15073377 DOI: 10.1126/Science.1094301 |
0.508 |
|
| 2004 |
Wehrens XHT, Lehnart SE, Reiken SR, Marks AR. Ca2+/Calmodulin-Dependent Protein Kinase II Phosphorylation Regulates the Cardiac Ryanodine Receptor Circulation Research. 94. PMID 15016728 DOI: 10.1161/01.Res.0000125626.33738.E2 |
0.511 |
|
| 2004 |
Cui J, Matkovich SJ, deSouza N, Li S, Rosemblit N, Marks AR. Regulation of the type 1 inositol 1,4,5-trisphosphate receptor by phosphorylation at tyrosine 353. The Journal of Biological Chemistry. 279: 16311-6. PMID 14761954 DOI: 10.1074/Jbc.M400206200 |
0.372 |
|
| 2004 |
Wehrens XHT, Marks AR. Mechanisms of heart failure: emerging molecular targets Drug Discovery Today: Disease Mechanisms. 1: 9-15. DOI: 10.1016/J.Ddmec.2004.06.001 |
0.506 |
|
| 2003 |
Wehrens XHT, Marks AR. Altered function and regulation of cardiac ryanodine receptors in cardiac disease. Trends in Biochemical Sciences. 28: 671-678. PMID 14659699 DOI: 10.1016/J.Tibs.2003.10.003 |
0.534 |
|
| 2003 |
Lehnart SE, Huang F, Marx SO, Marks AR. Immunophilins and coupled gating of ryanodine receptors. Current Topics in Medicinal Chemistry. 3: 1383-1391. PMID 12871170 DOI: 10.2174/1568026033451907 |
0.46 |
|
| 2003 |
Wehrens XH, Lehnart SE, Huang F, Vest JA, Reiken SR, Mohler PJ, Sun J, Guatimosim S, Song LS, Rosemblit N, D'Armiento JM, Napolitano C, Memmi M, Priori SG, Lederer WJ, ... Marks AR, et al. FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell. 113: 829-40. PMID 12837242 DOI: 10.1016/S0092-8674(03)00434-3 |
0.493 |
|
| 2003 |
Ward CW, Reiken S, Marks AR, Marty I, Vassort G, Lacampagne A. Defects in ryanodine receptor calcium release in skeletal muscle from post-myocardial infarct rats The Faseb Journal. 17: 1517-1519. PMID 12824280 DOI: 10.1096/Fj.02-1083Fje |
0.433 |
|
| 2003 |
Reiken S, Wehrens XHT, Vest JA, Barbone A, Klotz S, Mancini D, Burkhoff D, Marks AR. β-Blockers Restore Calcium Release Channel Function and Improve Cardiac Muscle Performance in Human Heart Failure Circulation. 107: 2459-2466. PMID 12743001 DOI: 10.1161/01.Cir.0000068316.53218.49 |
0.506 |
|
| 2003 |
Mancini D, Pinney S, Burkhoff D, LaManca J, Itescu S, Burke E, Edwards N, Oz M, Marks AR. Use of Rapamycin Slows Progression of Cardiac Transplantation Vasculopathy Circulation. 108: 48-53. PMID 12742978 DOI: 10.1161/01.Cir.0000070421.38604.2B |
0.305 |
|
| 2003 |
Marks AR. A Guide for the Perplexed Towards an Understanding of the Molecular Basis of Heart Failure Circulation. 107: 1456-1459. PMID 12654597 DOI: 10.1161/01.Cir.0000059745.95643.83 |
0.507 |
|
| 2003 |
Reiken S, Lacampagne A, Zhou H, Kherani A, Lehnart SE, Ward C, Huang F, Gaburjakova M, Gaburjakova J, Rosemblit N, Warren MS, He KL, Yi GH, Wang J, Burkhoff D, ... ... Marks AR, et al. PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: defective regulation in heart failure. The Journal of Cell Biology. 160: 919-28. PMID 12629052 DOI: 10.1083/Jcb.200211012 |
0.519 |
|
| 2003 |
Marks AR. Calcium and the heart: a question of life and death Journal of Clinical Investigation. 111: 597-600. PMID 12618512 DOI: 10.1172/Jci18067 |
0.436 |
|
| 2003 |
Marks AR. Arrhythmias of the heart: beyond ion channels. Nature Medicine. 9: 263-264. PMID 12612571 DOI: 10.1038/Nm0303-263 |
0.438 |
|
| 2003 |
Kass RS, Kurokawa J, Marx SO, Marks AR. Leucine/isoleucine zipper coordination of ion channel macromolecular signaling complexes in the heart. Roles in inherited arrhythmias. Trends in Cardiovascular Medicine. 13: 52-6. PMID 12586439 DOI: 10.1016/S1050-1738(02)00211-6 |
0.419 |
|
| 2003 |
Reiken S, Gaburjakova M, Guatimosim S, Gomez AM, D'Armiento J, Burkhoff D, Wang J, Vassort G, Lederer WJ, Marks AR. Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts. Role of phosphatases and response to isoproterenol. The Journal of Biological Chemistry. 278: 444-53. PMID 12401811 DOI: 10.1074/Jbc.M207028200 |
0.459 |
|
| 2003 |
Zhou H, Reiken S, Kherani AR, Warren M, Burkhoff D, Wang J, Marks AR. Effects of beta-blockade treatment on impaired skeletal muscle function and ryanodine receptor/calcium release channel PKA hyperphosphorylation in ischemia-induced heart failure Journal of the American College of Cardiology. 41: 154. DOI: 10.1016/S0735-1097(03)81765-5 |
0.468 |
|
| 2002 |
Marx SO, Marks AR. Regulation of the ryanodine receptor in heart failure Basic Research in Cardiology, Supplement. 97. PMID 12479234 DOI: 10.1007/S003950200029 |
0.551 |
|
| 2002 |
DeSouza N, Reiken S, Ondrias K, Yang YM, Matkovich S, Marks AR. Protein kinase A and two phosphatases are components of the inositol 1,4,5-trisphosphate receptor macromolecular signaling complex. The Journal of Biological Chemistry. 277: 39397-400. PMID 12167631 DOI: 10.1074/Jbc.M207059200 |
0.433 |
|
| 2002 |
Marks AR. Clinical implications of cardiac ryanodine receptor/calcium release channel mutations linked to sudden cardiac death Circulation. 106: 8-10. PMID 12093760 DOI: 10.1161/01.Cir.0000021746.82888.83 |
0.538 |
|
| 2002 |
Marks AR, Marx SO, Reiken S. Regulation of ryanodine receptors via macromolecular complexes: a novel role for leucine/isoleucine zippers. Trends in Cardiovascular Medicine. 12: 166-170. PMID 12069756 DOI: 10.1016/S1050-1738(02)00156-1 |
0.514 |
|
| 2002 |
Semsarian C, Ahmad I, Giewat M, Georgakopoulos D, Schmitt JP, McConnell BK, Reiken S, Mende U, Marks AR, Kass DA, Seidman CE, Seidman JG. The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model. The Journal of Clinical Investigation. 109: 1013-20. PMID 11956238 DOI: 10.1172/Jci200214677 |
0.478 |
|
| 2002 |
Fury M, Marx SO, Marks AR. Molecular BKology: the study of splicing and dicing. Science's Stke : Signal Transduction Knowledge Environment. 2002: pe12. PMID 11891347 DOI: 10.1126/Stke.2002.123.Pe12 |
0.387 |
|
| 2002 |
Marks AR, Priori S, Memmi M, Kontula K, Laitinen PJ. Involvement of the cardiac ryanodine receptor/calcium release channel in catecholaminergic polymorphic ventricular tachycardia. Journal of Cellular Physiology. 190: 1-6. PMID 11807805 DOI: 10.1002/Jcp.10031 |
0.497 |
|
| 2002 |
Marx SO, Kurokawa J, Reiken S, Motoike H, D'Armiento J, Marks AR, Kass RS. Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science (New York, N.Y.). 295: 496-9. PMID 11799244 DOI: 10.1126/Science.1066843 |
0.417 |
|
| 2002 |
Marks AR. Ryanodine receptors, FKBP12, and heart failure. Frontiers in Bioscience. 7. DOI: 10.2741/Marks |
0.516 |
|
| 2002 |
Marks AR, Reiken S, Marx SO. Progression of heart failure: is protein kinase a hyperphosphorylation of the ryanodine receptor a contributing factor? Circulation. 105: 272-275. DOI: 10.1161/Circ.105.3.272 |
0.506 |
|
| 2001 |
Reiken S, Gaburjakova M, Gaburjakova J, He KL, Prieto A, Becker E, Yi GH, Wang J, Burkhoff D, Marks AR. β-adrenergic receptor blockers restore cardiac calcium release channel (ryanodine receptor) structure and function in heart failure Circulation. 104: 2843-2848. PMID 11733405 DOI: 10.1161/Hc4701.099578 |
0.469 |
|
| 2001 |
Barbone A, Holmes JW, Heerdt PM, The' AH, Naka Y, Joshi N, Daines M, Marks AR, Oz MC, Burkhoff D. Comparison of right and left ventricular responses to left ventricular assist device support in patients with severe heart failure: a primary role of mechanical unloading underlying reverse remodeling. Circulation. 104: 670-5. PMID 11489773 DOI: 10.1161/Hc3101.093903 |
0.327 |
|
| 2001 |
Marx SO, Gaburjakova J, Gaburjakova M, Henrikson C, Ondrias K, Marks AR. Coupled gating between cardiac calcium release channels (ryanodine receptors). Circulation Research. 88: 1151-8. PMID 11397781 DOI: 10.1161/Hh1101.091268 |
0.481 |
|
| 2001 |
Marx SO, Reiken S, Hisamatsu Y, Gaburjakova M, Gaburjakova J, Yang Y, Rosemblit N, Marks AR. Phosphorylation-Dependent Regulation of Ryanodine Receptors: A Novel Role for Leucine/Isoleucine Zippers Journal of Cell Biology. 153: 699-708. PMID 11352932 DOI: 10.1083/Jcb.153.4.699 |
0.392 |
|
| 2001 |
Gaburjakova M, Gaburjakova J, Reiken S, Huang F, Marx SO, Rosemblit N, Marks AR. FKBP12 binding modulates ryanodine receptor channel gating. Journal of Biological Chemistry. 276: 16931-16935. PMID 11279144 DOI: 10.1074/Jbc.M100856200 |
0.438 |
|
| 2001 |
Marks AR. Ryanodine receptors/Calcium release channels in heart failure and sudden cardiac death Journal of Molecular and Cellular Cardiology. 33: 615-624. PMID 11273716 DOI: 10.1006/Jmcc.2000.1343 |
0.545 |
|
| 2000 |
Heerdt PM, Holmes JW, Cai B, Barbone A, Madigan JD, Reiken S, Lee DL, Oz MC, Marks AR, Burkhoff D. Chronic unloading by left ventricular assist device reverses contractile dysfunction and alters gene expression in end-stage heart failure. Circulation. 102: 2713-9. PMID 11094037 DOI: 10.1161/01.Cir.102.22.2713 |
0.413 |
|
| 2000 |
Marks AR. Cardiac intracellular calcium release channels: role in heart failure. Circulation Research. 87: 8-11. PMID 10884365 DOI: 10.1161/01.Res.87.1.8 |
0.548 |
|
| 2000 |
Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell. 101: 365-376. PMID 10830164 DOI: 10.1016/S0092-8674(00)80847-8 |
0.529 |
|
| 2000 |
Jayaraman T, Marks AR. Calcineurin is downstream of the inositol 1,4,5-trisphosphate receptor in the apoptotic and cell growth pathways. Journal of Biological Chemistry. 275: 6417-6420. PMID 10692444 DOI: 10.1074/Jbc.275.9.6417 |
0.354 |
|
| 1999 |
Kobrinsky E, Spielman AI, Rosenzweig S, Marks AR. Ceramide triggers intracellular calcium release via the IP(3) receptor in Xenopus laevis oocytes. The American Journal of Physiology. 277: C665-72. PMID 10516096 DOI: 10.1152/Ajpcell.1999.277.4.C665 |
0.401 |
|
| 1998 |
Ondrias K, Marx SO, Gaburjakova M, Marks AR. FKBP12 modulates gating of the ryanodine receptor/calcium release channel. Annals of the New York Academy of Sciences. 853: 149-56. PMID 10603943 DOI: 10.1111/J.1749-6632.1998.Tb08263.X |
0.437 |
|
| 1998 |
Marx SO, Ondrias K, Marks AR. Coupled gating between individual skeletal muscle Ca2+ release channels (ryanodine receptors) Science (New York, N.Y.). 281: 818-21. PMID 9694652 DOI: 10.1126/Science.281.5378.818 |
0.466 |
|
| 1997 |
Jayaraman T, Marks AR. T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis. Molecular and Cellular Biology. 17: 3005-3012. PMID 9154798 DOI: 10.1128/Mcb.17.6.3005 |
0.359 |
|
| 1997 |
Marks AR. Intracellular calcium-release channels: Regulators of cell life and death American Journal of Physiology - Heart and Circulatory Physiology. 272. PMID 9124414 DOI: 10.1152/Ajpheart.1997.272.2.H597 |
0.502 |
|
| 1996 |
Marks AR. Expression and regulation of ryanodine receptor/calcium release channels Trends in Cardiovascular Medicine. 6: 130-135. PMID 21232286 DOI: 10.1016/1050-1738(96)00035-7 |
0.541 |
|
| 1996 |
Marks AR. Cellular functions of immunophilins Physiological Reviews. 76: 631-649. PMID 8757784 DOI: 10.1152/Physrev.1996.76.3.631 |
0.408 |
|
| 1996 |
Kaftan E, Marks AR, Ehrlich BE. Effects of rapamycin on ryanodine receptor/Ca(2+)-release channels from cardiac muscle. Circulation Research. 78: 990-7. PMID 8635249 DOI: 10.1161/01.Res.78.6.990 |
0.521 |
|
| 1996 |
Maki T, Gruver EJ, Davidoff AJ, Izzo N, Toupin D, Colucci W, Marks AR, Marsh JD. Regulation of calcium channel expression in neonatal myocytes by catecholamines Journal of Clinical Investigation. 97: 656-663. PMID 8609220 DOI: 10.1172/Jci118462 |
0.406 |
|
| 1996 |
Marks AR. Immunophilin modulation of calcium channel gating Methods: a Companion to Methods in Enzymology. 9: 177-187. DOI: 10.1006/Meth.1996.0024 |
0.44 |
|
| 1995 |
Kobrinsky E, Ondrias K, Marks AR. Expressed ryanodine receptor can substitute for the inositol 1,4,5-trisphosphate receptor in Xenopus laevis oocytes during progesterone-induced maturation. Developmental Biology. 172: 531-40. PMID 8612969 DOI: 10.1006/Dbio.1995.8058 |
0.437 |
|
| 1995 |
Go LO, Moschella MC, Watras J, Handa KK, Fyfe BS, Marks AR. Differential regulation of two types of intracellular calcium release channels during end-stage heart failure. The Journal of Clinical Investigation. 95: 888-94. PMID 7860772 DOI: 10.1172/Jci117739 |
0.496 |
|
| 1995 |
Harnick DJ, Jayaraman T, Ma Y, Mulieri P, Go LO, Marks AR. The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation. The Journal of Biological Chemistry. 270: 2833-40. PMID 7852357 DOI: 10.1074/Jbc.270.6.2833 |
0.353 |
|
| 1995 |
Ma Y, Kobrinsky E, Marks AR. Cloning and expression of a novel truncated calcium channel from non-excitable cells. Journal of Biological Chemistry. 270: 483-493. PMID 7814415 DOI: 10.1074/Jbc.270.1.483 |
0.421 |
|
| 1995 |
Jayaraman T, Ondriasová E, Ondrias K, Harnick DJ, Marks AR. The inositol 1,4,5-trisphosphate receptor is essential for T-cell receptor signaling. Proceedings of the National Academy of Sciences of the United States of America. 92: 6007-11. PMID 7597070 DOI: 10.1073/Pnas.92.13.6007 |
0.374 |
|
| 1995 |
Marx SO, Jayaraman T, Go LO, Marks AR. Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells. Circulation Research. 76: 412-7. PMID 7532117 DOI: 10.1161/01.Res.76.3.412 |
0.304 |
|
| 1995 |
Moschella MC, Watras J, Jayaraman T, Marks AR. Inositol 1,4,5-trisphosphate receptor in skeletal muscle: differential expression in myofibres. Journal of Muscle Research and Cell Motility. 16: 390-400. PMID 7499479 DOI: 10.1007/Bf00114504 |
0.361 |
|
| 1995 |
Go LO, Harnick DJ, Marx SO, Fyfe BS, Marks AR, Watras J. 770-5 Chamber Specific Regulation of the Sarcoplasmic Reticulum Calcium ATPase Pump In Human Heart Failure Journal of the American College of Cardiology. 25. DOI: 10.1016/0735-1097(95)92635-I |
0.426 |
|
| 1994 |
Brillantes A-B, Bezprozvannaya S, Marks AR. Developmental and tissue-specific regulation of rabbit skeletal and cardiac muscle calcium channels involved in excitation-contraction coupling. Circulation Research. 75: 503-510. PMID 8062423 DOI: 10.1161/01.Res.75.3.503 |
0.455 |
|
| 1994 |
Fitzgerald M, Neylon CB, Marks AR, Woodcock EA. Reduced Ryanodine Receptor Content in Isolated Neonatal Cardiomyocytes Compared with the Intact Tissue Journal of Molecular and Cellular Cardiology. 26: 1261-1265. PMID 7869387 DOI: 10.1006/Jmcc.1994.1145 |
0.339 |
|
| 1994 |
Brillantes AB, Ondrias K, Scott A, Kobrinsky E, Ondriasová E, Moschella MC, Jayaraman T, Landers M, Ehrlich BE, Marks AR. Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. Cell. 77: 513-23. PMID 7514503 DOI: 10.1016/0092-8674(94)90214-3 |
0.473 |
|
| 1993 |
Moschella MC, Marks AR. Inositol 1,4,5-trisphosphate receptor expression in cardiac myocytes. The Journal of Cell Biology. 120: 1137-46. PMID 8382205 DOI: 10.1083/Jcb.120.5.1137 |
0.515 |
|
| 1992 |
Takahashi T, Allen PD, Lacro RV, Marks AR, Dennis AR, Schoen FJ, Grossman W, Marsh JD, Izumo S. Expression of dihydropyridine receptor (Ca2+ channel) and calsequestrin genes in the myocardium of patients with end-stage heart failure. The Journal of Clinical Investigation. 90: 927-35. PMID 1326001 DOI: 10.1172/Jci115969 |
0.475 |
|
| 1992 |
Brillantes AM, Allen P, Takahashi T, Izumo S, Marks AR. Differences in cardiac calcium release channel (ryanodine receptor) expression in myocardium from patients with end-stage heart failure caused by ischemic versus dilated cardiomyopathy. Circulation Research. 71: 18-26. PMID 1318794 DOI: 10.1161/01.Res.71.1.18 |
0.461 |
|
| 1992 |
Maki T, Gruver EJ, Toupin D, Marks AR, Marsh JD. Norepinephrine regulates DHP-receptor message in rat cardiac myocytes Journal of Molecular and Cellular Cardiology. 24. DOI: 10.1016/0022-2828(92)92941-5 |
0.342 |
|
| 1991 |
Marks AR, Taubman MB, Saito A, Dai Y, Fleischer S. The ryanodine receptor/junctional channel complex is regulated by growth factors in a myogenic cell line. The Journal of Cell Biology. 114: 303-12. PMID 1649198 DOI: 10.1083/Jcb.114.2.303 |
0.427 |
|
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