| Year |
Citation |
Score |
| 2013 |
Chen YT, Brinen LS, Kerr ID, Hansell E, Doyle PS, McKerrow JH, Roush WR. Structure of WRR-483 bound to cruzain Plos Neglected Tropical Diseases. DOI: 10.1371/Journal.Pntd.0000825.G003 |
0.39 |
|
| 2010 |
Chen YT, Brinen LS, Kerr ID, Hansell E, Doyle PS, McKerrow JH, Roush WR. In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. Plos Neglected Tropical Diseases. 4. PMID 20856868 DOI: 10.1371/Journal.Pntd.0000825 |
0.399 |
|
| 2010 |
Kerr ID, Wu P, Marion-Tsukamaki R, Mackey ZB, Brinen LS. Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei. Plos Neglected Tropical Diseases. 4: e701. PMID 20544024 DOI: 10.1371/Journal.Pntd.0000701 |
0.351 |
|
| 2010 |
He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, ... ... Brinen LS, et al. A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. The Journal of Biological Chemistry. 285: 18516-27. PMID 20378535 DOI: 10.1074/Jbc.M109.086181 |
0.333 |
|
| 2010 |
Brak K, Kerr ID, Barrett KT, Fuchi N, Debnath M, Ang K, Engel JC, McKerrow JH, Doyle PS, Brinen LS, Ellman JA. Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy. Journal of Medicinal Chemistry. 53: 1763-73. PMID 20088534 DOI: 10.1021/Jm901633V |
0.382 |
|
| 2009 |
Bryant C, Kerr ID, Debnath M, Ang KK, Ratnam J, Ferreira RS, Jaishankar P, Zhao D, Arkin MR, McKerrow JH, Brinen LS, Renslo AR. Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorganic & Medicinal Chemistry Letters. 19: 6218-21. PMID 19773167 DOI: 10.1016/J.Bmcl.2009.08.098 |
0.397 |
|
| 2009 |
Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. The Journal of Biological Chemistry. 284: 25697-703. PMID 19620707 DOI: 10.1074/Jbc.M109.014340 |
0.447 |
|
| 2009 |
Kerr ID, Lee JH, Pandey KC, Harrison A, Sajid M, Rosenthal PJ, Brinen LS. Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity. Journal of Medicinal Chemistry. 52: 852-7. PMID 19128015 DOI: 10.1021/Jm8013663 |
0.444 |
|
| 2009 |
Huang R, Que X, Hirata K, Brinen LS, Lee JH, Hansell E, Engel J, Sajid M, Reed S. The cathepsin L of Toxoplasma gondii (TgCPL) and its endogenous macromolecular inhibitor, toxostatin. Molecular and Biochemical Parasitology. 164: 86-94. PMID 19111576 DOI: 10.1016/J.Molbiopara.2008.11.012 |
0.341 |
|
| 2008 |
Stack CM, Caffrey CR, Donnelly SM, Seshaadri A, Lowther J, Tort JF, Collins PR, Robinson MW, Xu W, McKerrow JH, Craik CS, Geiger SR, Marion R, Brinen LS, Dalton JP. Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. The Journal of Biological Chemistry. 283: 9896-908. PMID 18160404 DOI: 10.1074/Jbc.M708521200 |
0.427 |
|
| 2007 |
Nagatani RA, Gonzalez A, Shoichet BK, Brinen LS, Babbitt PC. Stability for function trade-offs in the enolase superfamily "catalytic module". Biochemistry. 46: 6688-95. PMID 17503785 DOI: 10.1021/Bi700507D |
0.339 |
|
| 2007 |
Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH. The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure (London, England : 1993). 15: 535-43. PMID 17502099 DOI: 10.1016/J.Str.2007.03.012 |
0.58 |
|
| 2007 |
Stack CM, Donnelly S, Lowther J, Xu W, Collins PR, Brinen LS, Dalton JP. The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: a Leu-12 to Pro-12 replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular events in prosegment removal. The Journal of Biological Chemistry. 282: 16532-43. PMID 17403677 DOI: 10.1074/Jbc.M611501200 |
0.339 |
|
| 2006 |
Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH. Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proceedings of the National Academy of Sciences of the United States of America. 103: 11503-8. PMID 16864794 DOI: 10.1073/Pnas.0600489103 |
0.634 |
|
| 2005 |
Choe Y, Brinen LS, Price MS, Engel JC, Lange M, Grisostomi C, Weston SG, Pallai PV, Cheng H, Hardy LW, Hartsough DS, McMakin M, Tilton RF, Baldino CM, Craik CS. Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease. Bioorganic & Medicinal Chemistry. 13: 2141-56. PMID 15727867 DOI: 10.1016/J.Bmc.2004.12.053 |
0.372 |
|
| 2003 |
Brinen LS, Stout TJ. Can mosquitoes be bitten? A new hope for anti-malarial drug design. Structure (London, England : 1993). 11: 1309-10. PMID 14604516 DOI: 10.1016/J.Str.2003.10.011 |
0.646 |
|
| 2003 |
Wang SX, Hur E, Sousa CA, Brinen L, Slivka EJ, Fletterick RJ. The extended interactions and Gla domain of blood coagulation factor Xa. Biochemistry. 42: 7959-66. PMID 12834348 DOI: 10.1021/Bi027320A |
0.514 |
|
| 2003 |
Huang L, Brinen LS, Ellman JA. Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain. Bioorganic & Medicinal Chemistry. 11: 21-9. PMID 12467703 DOI: 10.1016/S0968-0896(02)00427-3 |
0.468 |
|
| 2002 |
Que X, Ngo H, Lawton J, Gray M, Liu Q, Engel J, Brinen L, Ghosh P, Joiner KA, Reed SL. The cathepsin B of Toxoplasma gondii, toxopain-1, is critical for parasite invasion and rhoptry protein processing. The Journal of Biological Chemistry. 277: 25791-7. PMID 12000756 DOI: 10.1074/Jbc.M202659200 |
0.312 |
|
| 2002 |
Que X, Brinen LS, Perkins P, Herdman S, Hirata K, Torian BE, Rubin H, McKerrow JH, Reed SL. Cysteine proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica. Molecular and Biochemical Parasitology. 119: 23-32. PMID 11755183 DOI: 10.1016/S0166-6851(01)00387-5 |
0.366 |
|
| 2001 |
Caffrey CR, Hansell E, Lucas KD, Brinen LS, Alvarez Hernandez A, Cheng J, Gwaltney SL, Roush WR, Stierhof YD, Bogyo M, Steverding D, McKerrow JH. Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense. Molecular and Biochemical Parasitology. 118: 61-73. PMID 11704274 DOI: 10.1016/S0166-6851(01)00368-1 |
0.408 |
|
| 2000 |
Brinen LS, Que X, McKerrow JH, Reed SL. Homology modeling of Entamoeba histolytica cysteine proteinases reveals the basis for cathepsin L-like structure with cathepsin B-like specificity. Archives of Medical Research. 31: S63-4. PMID 11070225 DOI: 10.1016/S0188-4409(00)00154-5 |
0.357 |
|
| 2000 |
Brinen LS, Hansell E, Cheng J, Roush WR, McKerrow JH, Fletterick RJ. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure (London, England : 1993). 8: 831-40. PMID 10997902 DOI: 10.1016/S0969-2126(00)00173-8 |
0.629 |
|
| 1999 |
Huete-Pérez JA, Engel JC, Brinen LS, Mottram JC, McKerrow JH. Protease trafficking in two primitive eukaryotes is mediated by a prodomain protein motif. The Journal of Biological Chemistry. 274: 16249-56. PMID 10347181 DOI: 10.1074/Jbc.274.23.16249 |
0.347 |
|
| 1996 |
Schroeder DR, Colson KL, Klohr SE, Lee MS, Matson JA, Brinen LS, Clardy J. Pyrrolosporin A, a new antitumor antibiotic from Micromonospora sp. C39217-R109-7. II. Isolation, physico-chemical properties, spectroscopic study and X-ray analysis. The Journal of Antibiotics. 49: 865-72. PMID 8931719 DOI: 10.7164/Antibiotics.49.865 |
0.45 |
|
| 1996 |
Brinen LS, Willett WS, Craik CS, Fletterick RJ. X-ray structures of a designed binding site in trypsin show metal-dependent geometry. Biochemistry. 35: 5999-6009. PMID 8634241 DOI: 10.1021/Bi9530200 |
0.554 |
|
| 1996 |
Willett WS, Brinen LS, Fletterick RJ, Craik CS. Delocalizing trypsin specificity with metal activation. Biochemistry. 35: 5992-8. PMID 8634240 DOI: 10.1021/bi9530191 |
0.509 |
|
| 1996 |
Brinen LS, Willett WS, Craik CS, Fletterick RJ. X-ray structures of a designed binding site in trypsin–ecotin complex show metal-dependent geometry Acta Crystallographica Section a Foundations of Crystallography. 52: C213-C214. DOI: 10.1107/S0108767396090824 |
0.54 |
|
| 1994 |
Yu J, Hu XE, Ho DK, Bean MF, Stephens RE, Cassady JM, Brinen LS, Clardy J. Absolute Stereochemistry of (+)-Gigantecin from Annona coriacea (Annonaceae) The Journal of Organic Chemistry. 59: 1598-1599. DOI: 10.1021/Jo00086A003 |
0.43 |
|
| 1993 |
Watanabe N, Yamamoto K, Ihshikawa H, Yagi A, Sakata K, Brinen LS, Clardy J. New Chlorophyll-A-Related Compounds Isolated as Antioxidants from Marine Bivalves Journal of Natural Products. 56: 305-317. DOI: 10.1021/Np50093A001 |
0.397 |
|
| 1993 |
Unson MD, Rose CB, Faulkner DJ, Brinen LS, Steiner JR, Clardy J. New polychlorinated amino acid derivatives from the marine sponge Dysidea herbacea The Journal of Organic Chemistry. 58: 6336-6343. DOI: 10.1021/Jo00075A029 |
0.448 |
|
| 1992 |
Ayer WA, Sun M, Browne LM, Brinen LS, Clardy J. Chemical investigation of the metabolites from the Canadian tuckahoe, Polyporus tuberaster. Journal of Natural Products. 55: 649-53. PMID 1517736 DOI: 10.1021/Np50083A015 |
0.471 |
|
| 1992 |
Fuller RW, Cardellina JH, Kato Y, Brinen LS, Clardy J, Snader KM, Boyd MR. A pentahalogenated monoterpene from the red alga Portieria hornemannii produces a novel cytotoxicity profile against a diverse panel of human tumor cell lines. Journal of Medicinal Chemistry. 35: 3007-11. PMID 1501227 DOI: 10.1021/Jm00094A012 |
0.438 |
|
| 1992 |
Gupta S, Krasnoff SB, Roberts DW, Renwick JAA, Brinen LS, Clardy J. Structure of efrapeptins from the fungus Tolypocladium niveum: peptide inhibitors of mitochondrial ATPase The Journal of Organic Chemistry. 57: 2306-2313. DOI: 10.1021/Jo00034A022 |
0.431 |
|
| 1992 |
Yamamoto K, Sakata K, Watanabe N, Yagi A, Brinen LS, Clardy J. Chlorophyllonic acid and methyl ester, a new chlorophyll a related compound isolated as an antioxidant from short-necked clam, ruditapes philippinarum Tetrahedron Letters. 33: 2587-2588. DOI: 10.1016/S0040-4039(00)92250-0 |
0.444 |
|
| 1992 |
Kubo I, Ying B, Castillo M, Brinen LS, Clardy J. Podoandin, a molluscicidal sesquiterpene lactone from Podocarpus andina Phytochemistry. 31: 1545-1548. DOI: 10.1016/0031-9422(92)83103-6 |
0.405 |
|
| 1991 |
Gupta S, Krasnoff SB, Roberts DW, Renwick JAA, Brinen LS, Clardy J. Structures of the efrapeptins: potent inhibitors of mitochondrial ATPase from the fungus Tolypocladium niveum Journal of the American Chemical Society. 113: 707-709. DOI: 10.1021/Ja00002A068 |
0.477 |
|
| 1991 |
Gustafson KR, Munro MH, Blunt JW, Cardellina JH, McMahon JB, Gulakowski RJ, Cragg GM, Cox PA, Brinen LS, Clardy J, Boyd MR. HIV inhibitory natural products. 3. Diterpenes from and Tetrahedron. 47: 4547-4554. DOI: 10.1016/S0040-4020(01)86461-9 |
0.395 |
|
| 1991 |
de Silva E, Racok JS, Andersen RJ, Allen TM, Brinen LS, Clardy J. Neamphine, a sulfur containing aromatic heterocycle isolated from the marine sponge neamphius huxleyi Tetrahedron Letters. 32: 2707-2710. DOI: 10.1016/0040-4039(91)85064-C |
0.478 |
|
| 1991 |
Pathirana C, Dwight R, Jensen PR, Fenical W, Delgado A, Brinen LS, Clardy J. Structure and synthesis of a new butanolide from a marine actinomycete Tetrahedron Letters. 32: 7001-7004. DOI: 10.1016/0040-4039(91)85024-Y |
0.495 |
|
| 1991 |
Spencer GF, Jones BE, Plattner RD, Barnekow DE, Brinen LS, Clardy J. A pterocarpan and two isoflavans from alfalfa Phytochemistry. 30: 4147-4149. DOI: 10.1016/0031-9422(91)83483-2 |
0.413 |
|
| 1990 |
LaLonde RT, Perakyla H, Ishiguro Y, Clardy J, Brinen LS. Structure of an anhydride related to a mutagenic component of drinking water, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone. Chemical Research in Toxicology. 3: 404-5. PMID 2133090 |
0.333 |
|
| 1990 |
Moore BS, Chen JL, Patterson GML, Moore RE, Brinen LS, Kato Y, Clardy J. [7.7]Paracyclophanes from blue-green algae Journal of the American Chemical Society. 112: 4061-4063. DOI: 10.1021/Ja00166A066 |
0.345 |
|
| 1990 |
Fusetani N, Yasumuro K, Kawai H, Natori T, Brinen L, Clardy J. Kalihinene and isokalihinol B, cytotoxic diterpene isonitriles from the marine sponge Acanthella klethra Tetrahedron Letters. 31: 3599-3602. DOI: 10.1016/S0040-4039(00)94453-8 |
0.458 |
|
| 1990 |
West RR, Mayne CL, Ireland CM, Brinen LS, Clardy J. Plakinidines: Cytotoxic alkaloid pigments from the fijian sponge plakortis sp Tetrahedron Letters. 31: 3271-3274. DOI: 10.1016/S0040-4039(00)89041-3 |
0.451 |
|
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