| Year |
Citation |
Score |
| 2024 |
He M, Piscelli BA, Cormanich RA, O'Hagan D. Conformational Analysis Explores the Role of Electrostatic Nonclassical CF···HC Hydrogen Bonding Interactions in Selectively Halogenated Cyclohexanes. The Journal of Organic Chemistry. 89: 4009-4018. PMID 38441063 DOI: 10.1021/acs.joc.3c02868 |
0.646 |
|
| 2023 |
Dobson LS, Zhang Q, McKay BA, Oke O, Isanbor C, Khan MF, Piscelli BA, Cordes DB, Cormanich RA, Murphy CD, O'Hagan D. Aryl (β,β',β″-Trifluoro)--butyl: A Candidate Motif for the Discovery of Bioactives. Organic Letters. PMID 37682007 DOI: 10.1021/acs.orglett.3c02236 |
0.583 |
|
| 2023 |
Piscelli BA, O'Hagan D, Cormanich RA. Contribution of Hyperconjugation and Inductive Effects to the -anomeric Effect in 4-Substituted Methoxycyclohexanes. The Journal of Physical Chemistry. A. 127: 724-728. PMID 36649066 DOI: 10.1021/acs.jpca.2c08090 |
0.612 |
|
| 2022 |
Yu C, Piscelli BA, Maharik NA, Cordes DB, Slawin AMZ, Cormanich RA, O'Hagan D. Unexpected triaxial preferences in some all- 1,3,5-trifluorocyclohexanes. Chemical Communications (Cambridge, England). PMID 36317533 DOI: 10.1039/d2cc05058g |
0.618 |
|
| 2022 |
Poskin TJ, Piscelli BA, Yoshida K, Cordes DB, Slawin AMZ, Cormanich RA, Yamada S, O'Hagan D. Janus faced fluorocyclohexanes for supramolecular assembly: synthesis and solid state structures of equatorial mono-, di- and tri alkylated cyclohexanes and with tri-axial C-F bonds to impart polarity. Chemical Communications (Cambridge, England). PMID 35758098 DOI: 10.1039/d2cc03010a |
0.65 |
|
| 2021 |
Clark JL, Taylor A, Geddis A, Neyyappadath RM, Piscelli BA, Yu C, Cordes DB, Slawin AMZ, Cormanich RA, Guldin S, O'Hagan D. Supramolecular packing of alkyl substituted Janus face all- 2,3,4,5,6-pentafluorocyclohexyl motifs. Chemical Science. 12: 9712-9719. PMID 34349942 DOI: 10.1039/d1sc02130c |
0.65 |
|
| 2021 |
Piscelli BA, O'Hagan D, Cormanich RA. The contribution of non-classical CHOC hydrogen bonds to the anomeric effect in fluoro and oxa-methoxycyclohexanes. Physical Chemistry Chemical Physics : Pccp. PMID 33688868 DOI: 10.1039/d0cp06646j |
0.632 |
|
| 2020 |
O'Hagan D, Yu C, Kütt A, Röschenthaler GV, Lebl T, Cordes DB, Slawin AMZ, Bűhl M. Janus face all-cis 1,2,4,5-tetrakis(trifluoromethyl)- and all-cis 1,2,3,4,5,6-hexakis(trifluoromethyl)- cyclohexanes. Angewandte Chemie (International Ed. in English). PMID 32691941 DOI: 10.1002/Anie.202008662 |
0.321 |
|
| 2020 |
Piscelli BA, Sanders W, Yu C, Al Maharik N, Lebl T, Cormanisch RA, O'Hagan D. Fluorine induced pseudo-anomeric effects in methoxycyclohexanes through electrostatic 1,3-diaxial interactions. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32588927 DOI: 10.1002/Chem.202003058 |
0.387 |
|
| 2020 |
O'Hagan D. Polar organofluorine substituents: Multivicinal fluorines on alkyl chains and alicyclic rings. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32083392 DOI: 10.1002/Chem.202000178 |
0.4 |
|
| 2020 |
Al-Maharik N, Cordes DB, Slawin AMZ, Bühl M, O'Hagan D. Probing the helical integrity of multivicinal all-syn-fluoro alkanes. Organic & Biomolecular Chemistry. PMID 31942902 DOI: 10.1039/C9Ob02647A |
0.323 |
|
| 2020 |
O'Hagan D. Frontispiece: Polar Organofluorine Substituents: Multivicinal Fluorines on Alkyl Chains and Alicyclic Rings Chemistry: a European Journal. 26. DOI: 10.1002/Chem.202083662 |
0.315 |
|
| 2019 |
Fang Z, Cordes DB, Slawin AMZ, O'Hagan D. Fluorine containing cyclopropanes: synthesis of aryl substituted all-cis 1,2,3-trifluorocyclopropanes, a facially polar motif. Chemical Communications (Cambridge, England). PMID 31414105 DOI: 10.1039/C9Cc05749H |
0.331 |
|
| 2019 |
O'Hagan D, Bello D, Rubanu MG, Bandaranayaka N, Götze JP, Bühl M. Acetyl coenzyme A analogues as rationally designed inhibitors of citrate synthase. Chembiochem : a European Journal of Chemical Biology. PMID 30605257 DOI: 10.1002/Cbic.201800700 |
0.351 |
|
| 2019 |
Zhang Q, Teschers CS, Callejo R, Yang M, Wang M, Silk PJ, Ryall K, Roscoe LE, Cordes DB, Slawin AM, O'Hagan D. Fluorine in pheromones: Synthesis of fluorinated 12-dodecanolides as emerald ash borer pheromone mimetics Tetrahedron. 75: 2917-2922. DOI: 10.1016/J.Tet.2019.03.025 |
0.349 |
|
| 2018 |
Lowe PT, Dall'Angelo S, Devine A, Zanda M, O'Hagan D. Enzymatic fluorination of biotin and tetrazine conjugates for pre-targeting approaches to PET imaging. Chembiochem : a European Journal of Chemical Biology. PMID 29966048 DOI: 10.1002/Cbic.201800234 |
0.305 |
|
| 2018 |
O'Hagan D, Bykova T, Slawin A, Buehl M, Lebl T, Al-Maharik N. Benzylic functionalisation of phenyl all cis-2, 3, 5, 6 -tetrafluoro -cyclohexane provides access to new organo-fluorine building blocks. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29882357 DOI: 10.1002/Chem.201802166 |
0.7 |
|
| 2018 |
Rodil A, Bosisio S, Ayoup MS, Quinn L, Cordes DB, Slawin AMZ, Murphy CD, Michel J, O'Hagan D. Metabolism and hydrophilicity of the polarised 'Janus face' all- tetrafluorocyclohexyl ring, a candidate motif for drug discovery. Chemical Science. 9: 3023-3028. PMID 29732086 DOI: 10.1039/C8Sc00299A |
0.325 |
|
| 2018 |
Ahmed L, Zhang Y, Block E, Buehl M, Corr MJ, Cormanich RA, Gundala S, Matsunami H, O'Hagan D, Ozbil M, Pan Y, Sekharan S, Ten N, Wang M, Yang M, et al. Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by ()-muscone and diverse other musk-smelling compounds. Proceedings of the National Academy of Sciences of the United States of America. PMID 29632183 DOI: 10.1073/Pnas.1713026115 |
0.748 |
|
| 2018 |
Keddie NS, Champagne PA, Desroches J, Paquin JF, O'Hagan D. Stereochemical outcomes of C-F activation reactions of benzyl fluoride. Beilstein Journal of Organic Chemistry. 14: 106-113. PMID 29441134 DOI: 10.3762/Bjoc.14.6 |
0.384 |
|
| 2017 |
O'Hagan D, Manan MAFA, Cordes D, Slawin A, Liao V, CHua H, Chebib M, Buehl M. The synthesis and evaluation of fluoro-, trifluoromethyl, and iodo- muscimols as GABA agonists. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28598039 DOI: 10.1002/Chem.201701443 |
0.653 |
|
| 2017 |
Cormanich RA, O'Hagan D, Bühl M. Hyperconjugation is the Source of Helicity in Perfluorinated n-Alkanes. Angewandte Chemie (International Ed. in English). PMID 28561937 DOI: 10.1002/Anie.201704112 |
0.633 |
|
| 2017 |
Bykova T, Al-Maharik N, Slawin AMZ, O'Hagan D. Fluorinated cyclohexanes: Synthesis of amine building blocks of the all-cis 2,3,5,6-tetrafluorocyclohexylamine motif. Beilstein Journal of Organic Chemistry. 13: 728-733. PMID 28503208 DOI: 10.3762/Bjoc.13.72 |
0.375 |
|
| 2016 |
Jones MJ, Callejo R, Slawin AM, Bühl M, O'Hagan D. Organofluorine chemistry: Difluoromethylene motifs spaced 1,3 to each other imparts facial polarity to a cyclohexane ring. Beilstein Journal of Organic Chemistry. 12: 2823-2827. PMID 28144355 DOI: 10.3762/Bjoc.12.281 |
0.389 |
|
| 2016 |
Bartholomé A, Janso JE, Reilly U, O'Hagan D. Fluorometabolite biosynthesis: isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus. Organic & Biomolecular Chemistry. PMID 27845468 DOI: 10.1039/C6Ob02291J |
0.314 |
|
| 2016 |
Al-Maharik N, Kirsch P, Slawin AM, Cordes DB, O'Hagan D. Fluorinated liquid crystals: evaluation of selectively fluorinated facially polarised cyclohexyl motifs for liquid crystal applications. Organic & Biomolecular Chemistry. PMID 27722421 DOI: 10.1039/C6Ob01986B |
0.354 |
|
| 2016 |
Callejo R, Corr MJ, Yang M, Wang M, Cordes DB, Slawin AM, O'Hagan D. Fluorinated Musk Fragrances: The CF2 Group as a Conformational Bias Influencing the Odour of Civetone and (R)-Muscone. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27149882 DOI: 10.1002/Chem.201600519 |
0.331 |
|
| 2016 |
Fang Z, Al-Maharik N, Slawin AM, Bühl M, O'Hagan D. Polar alicyclic rings: synthesis and structure of all cis-1,2,3,4-tetrafluorocyclopentane. Chemical Communications (Cambridge, England). PMID 26996764 DOI: 10.1039/C6Cc01348A |
0.308 |
|
| 2016 |
Bykova T, Al-Maharik N, Slawin AM, O'Hagan D. Multicomponent reactions of methyl substituted all-cis tetrafluorocyclohexane aldehydes. Organic & Biomolecular Chemistry. 14: 1117-23. PMID 26646211 DOI: 10.1039/C5Ob02334C |
0.372 |
|
| 2015 |
Ma L, Bartholome A, Tong MH, Qin Z, Yu Y, Shepherd T, Kyeremeh K, Deng H, O'Hagan D. Identification of a fluorometabolite from sp. MA37: (234)-5-fluoro-2,3,4-trihydroxypentanoic acid. Chemical Science. 6: 1414-1419. PMID 29861965 DOI: 10.1039/C4Sc03540B |
0.31 |
|
| 2015 |
Ayoup MS, Cordes DB, Slawin AM, O'Hagan D. Selectively fluorinated cyclohexane building blocks: Derivatives of carbonylated all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane. Beilstein Journal of Organic Chemistry. 11: 2671-6. PMID 26877788 DOI: 10.3762/Bjoc.11.287 |
0.314 |
|
| 2015 |
Bello D, O'Hagan D. Lewis acid-promoted hydrofluorination of alkynyl sulfides to generate α-fluorovinyl thioethers. Beilstein Journal of Organic Chemistry. 11: 1902-9. PMID 26664609 DOI: 10.3762/Bjoc.11.205 |
0.338 |
|
| 2015 |
Corr MJ, Cormanich RA, von Hahmann CN, Bühl M, Cordes DB, Slawin AM, O'Hagan D. Fluorine in fragrances: exploring the difluoromethylene (CF2) group as a conformational constraint in macrocyclic musk lactones. Organic & Biomolecular Chemistry. PMID 26584449 DOI: 10.1039/C5Ob02023A |
0.657 |
|
| 2015 |
Cormanich RA, Keddie NS, Rittner R, O'Hagan D, Bühl M. Particularly strong C-Hπ interactions between benzene and all-cis 1,2,3,4,5,6-hexafluorocyclohexane. Physical Chemistry Chemical Physics : Pccp. 17: 29475-8. PMID 26507700 DOI: 10.1039/C5Cp04537A |
0.641 |
|
| 2015 |
Keddie NS, Slawin AM, Lebl T, Philp D, O'Hagan D. All-cis 1,2,3,4,5,6-hexafluorocyclohexane is a facially polarized cyclohexane. Nature Chemistry. 7: 483-8. PMID 25991526 DOI: 10.1038/Nchem.2232 |
0.382 |
|
| 2015 |
Cormanich RA, Rittner R, O'Hagan D, Bühl M. Inter- and intramolecular CF···co interactions on aliphatic and cyclohexane carbonyl derivatives. Journal of Computational Chemistry. PMID 25903504 DOI: 10.1002/Jcc.23918 |
0.644 |
|
| 2015 |
Ayoup MS, Cordes DB, Slawin AM, O'Hagan D. Fluorine containing amino acids: synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif. Organic & Biomolecular Chemistry. 13: 5621-4. PMID 25900403 DOI: 10.1039/C5Ob00650C |
0.349 |
|
| 2015 |
Bello D, Cormanich RA, O'Hagan D. Fluorovinyl Thioethers as Putative Steric and Electronic Thioester Enolate Mimetics: Chemoselective HF Addition to Acetylene Thioethers Australian Journal of Chemistry. 68: 72. DOI: 10.1071/Ch14298 |
0.642 |
|
| 2014 |
Cormanich RA, Rittner R, O'Hagan D, Bühl M. Analysis of CF···FC interactions on cyclohexane and naphthalene frameworks. The Journal of Physical Chemistry. A. 118: 7901-10. PMID 25127203 DOI: 10.1021/Jp504568C |
0.589 |
|
| 2014 |
Thompson S, Zhang Q, Onega M, McMahon S, Fleming I, Ashworth S, Naismith JH, Passchier J, O'Hagan D. A localized tolerance in the substrate specificity of the fluorinase enzyme enables "last-step" 18F fluorination of a RGD peptide under ambient aqueous conditions. Angewandte Chemie (International Ed. in English). 53: 8913-8. PMID 24989327 DOI: 10.1002/Anie.201403345 |
0.309 |
|
| 2014 |
Durie AJ, Fujiwara T, Cormanich R, Bühl M, Slawin AM, O'Hagan D. Synthesis and elaboration of all-cis-1,2,4,5-tetrafluoro-3-phenylcyclohexane: a polar cyclohexane motif. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 6259-63. PMID 24740763 DOI: 10.1002/Chem.201400354 |
0.679 |
|
| 2014 |
Cormanich RA, Durie A, Bjornsson R, Rittner R, O'Hagan D, Bühl M. Density Functional Study of Interactions between Fluorinated Cyclohexanes and Arenes Helvetica Chimica Acta. 97: 797-807. DOI: 10.1002/Hlca.201400049 |
0.612 |
|
| 2013 |
Skibi?ski M, Urbina-Blanco CA, Slawin AM, Nolan SP, O'Hagan D. Synthesis and structure of large difluoromethylene containing alicycles by ring closing metathesis (RCM). Organic & Biomolecular Chemistry. 11: 8209-13. PMID 24162143 DOI: 10.1039/C3Ob42062K |
0.346 |
|
| 2013 |
Urbina-Blanco CA, Skibi?ski M, O'Hagan D, Nolan SP. Accelerating influence of the gem-difluoromethylene group in a ring-closing olefin metathesis reaction. A Thorpe-Ingold effect? Chemical Communications (Cambridge, England). 49: 7201-3. PMID 23842904 DOI: 10.1039/C3Cc44312D |
0.31 |
|
| 2013 |
Dall'Angelo S, Zhang Q, Fleming IN, Piras M, Schweiger LF, O'Hagan D, Zanda M. Efficient bioconjugation of 5-fluoro-5-deoxy-ribose (FDR) to RGD peptides for positron emission tomography (PET) imaging of α(v)β(3) integrin receptor. Organic & Biomolecular Chemistry. 11: 4551-8. PMID 23733207 DOI: 10.1039/C3Ob40550H |
0.328 |
|
| 2013 |
Chia PW, Bello D, Slawin AM, O'Hagan D. Fluorinated 5- and 7-membered carbacycle motifs by reaction of difluorocarbene with acetylene ethers. Chemical Communications (Cambridge, England). 49: 2189-91. PMID 23385787 DOI: 10.1039/C3Cc39066G |
0.319 |
|
| 2012 |
Wang Y, Kirsch P, Lebl T, Slawin AM, O'Hagan D. The preferred conformation of erythro- and threo-1,2-difluorocyclododecanes. Beilstein Journal of Organic Chemistry. 8: 1271-8. PMID 23019458 DOI: 10.3762/Bjoc.8.143 |
0.377 |
|
| 2012 |
Durie AJ, Slawin AM, Lebl T, O'Hagan D. The synthesis of η-1,2,3,4,5,6-hexafluorocyclohexane (benzene hexafluoride) from benzene. Angewandte Chemie (International Ed. in English). 51: 10086-8. PMID 22968946 DOI: 10.1002/Anie.201205577 |
0.325 |
|
| 2012 |
Chia PW, Livesey MR, Slawin AM, van Mourik T, Wyllie DJ, O'Hagan D. 3-Fluoro-N-methyl-D-aspartic acid (3F-NMDA) stereoisomers as conformational probes for exploring agonist binding at NMDA receptors. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 8813-9. PMID 22692769 DOI: 10.1002/Chem.201200071 |
0.326 |
|
| 2012 |
Freitas MP, Bühl M, O'Hagan D, Cormanich RA, Tormena CF. Stereoelectronic interactions and the one-bond C-F coupling constant in sevoflurane. The Journal of Physical Chemistry. A. 116: 1677-82. PMID 22233417 DOI: 10.1021/jp211949m |
0.63 |
|
| 2012 |
O'Hagan D, Wang Y, Skibinski M, Slawin AMZ. Influence of the difluoromethylene group (CF2) on the conformation and properties of selected organic compounds Pure and Applied Chemistry. 84: 1587-1595. DOI: 10.1351/Pac-Con-11-09-26 |
0.309 |
|
| 2012 |
Smith DL, Slawin AMZ, O'Hagan D. Fluorine in Peptides: The Synthesis ofα-Fluoro-β-Amino Dipeptides by Direct Deoxofluorination/Rearrangement ofN-Seryl Dipeptides Helvetica Chimica Acta. 95: 2331-2347. DOI: 10.1002/Hlca.201200464 |
0.311 |
|
| 2011 |
Skibinski M, Wang Y, Slawin AM, Lebl T, Kirsch P, O'Hagan D. Alicyclic ring structure: conformational influence of the CF2 group in cyclododecanes. Angewandte Chemie (International Ed. in English). 50: 10581-4. PMID 21932273 DOI: 10.1002/Anie.201105060 |
0.316 |
|
| 2011 |
Durie AJ, Slawin AM, Lebl T, Kirsch P, O'Hagan D. Synthesis and structure of all-syn-1,2,3,4-tetrafluorocyclohexane. Chemical Communications (Cambridge, England). 47: 8265-7. PMID 21709894 DOI: 10.1039/C1Cc13016A |
0.36 |
|
| 2011 |
Campbell NH, Smith DL, Reszka AP, Neidle S, O'Hagan D. Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA Organic and Biomolecular Chemistry. 9: 1328-1331. PMID 21221451 DOI: 10.1039/C0Ob00886A |
0.332 |
|
| 2010 |
O'Hagan D. Organo-fluorine chemistry II. Beilstein Journal of Organic Chemistry. 6: 36. PMID 20502657 DOI: 10.3762/Bjoc.6.36 |
0.306 |
|
| 2010 |
Launay GG, Slawin AM, O'Hagan D. Prins fluorination cyclisations: Preparation of 4-fluoro-pyran and -piperidine heterocycles. Beilstein Journal of Organic Chemistry. 6: 41. PMID 20502655 DOI: 10.3762/Bjoc.6.41 |
0.348 |
|
| 2010 |
Buissonneaud DY, van Mourik T, O'Hagan D. A DFT study on the origin of the fluorine gauche effect in substituted fluoroethanes Tetrahedron. 66: 2196-2202. DOI: 10.1016/J.Tet.2010.01.049 |
0.321 |
|
| 2009 |
Deng H, McMahon SA, Eustáquio AS, Moore BS, Naismith JH, O'Hagan D. Mechanistic insights into water activation in SAM hydroxide adenosyltransferase (duf-62). Chembiochem : a European Journal of Chemical Biology. 10: 2455-9. PMID 19739191 DOI: 10.1002/Cbic.200900369 |
0.315 |
|
| 2009 |
Nasomjai P, Reed DW, Tozer DJ, Peach MJ, Slawin AM, Covello PS, O'Hagan D. Mechanistic insights into the cytochrome P450-mediated oxidation and rearrangement of littorine in tropane alkaloid biosynthesis. Chembiochem : a European Journal of Chemical Biology. 10: 2382-93. PMID 19693762 DOI: 10.1002/Cbic.200900318 |
0.333 |
|
| 2008 |
O'Hagan D. Themed series in organo-fluorine chemistry. Beilstein Journal of Organic Chemistry. 4: 11. PMID 18941483 DOI: 10.3762/Bjoc.4.11 |
0.329 |
|
| 2008 |
Hunter L, Kirsch P, Hamilton JT, O'Hagan D. The multi-vicinal fluoroalkane motif: an examination of 2,3,4,5-tetrafluorohexane stereoisomers. Organic & Biomolecular Chemistry. 6: 3105-8. PMID 18698469 DOI: 10.1039/B807449F |
0.313 |
|
| 2008 |
Hunter L, O'Hagan D. Multi-vicinal fluoroalkanes: a new class of organofluorine compounds. Organic & Biomolecular Chemistry. 6: 2843-8. PMID 18688475 DOI: 10.1039/B809432B |
0.333 |
|
| 2008 |
O'Hagan D. Understanding organofluorine chemistry. An introduction to the C-F bond. Chemical Society Reviews. 37: 308-19. PMID 18197347 DOI: 10.1039/B711844A |
0.379 |
|
| 2007 |
Clift MD, Ji H, Deniau GP, O'Hagan D, Silverman RB. Enantiomers of 4-amino-3-fluorobutanoic acid as substrates for γ-aminobutyric acid aminotransferase. Conformational probes for GABA binding Biochemistry. 46: 13819-13828. PMID 17988152 DOI: 10.1021/Bi701249Q |
0.305 |
|
| 2007 |
Hunter L, Slawin AM, Kirsch P, O'Hagan D. Synthesis and conformation of multi-vicinal fluoroalkane diastereoisomers. Angewandte Chemie (International Ed. in English). 46: 7887-90. PMID 17786905 DOI: 10.1002/Anie.200701988 |
0.317 |
|
| 2006 |
Hunter L, O'Hagan D, Slawin AM. Enantioselective synthesis of an all-syn four vicinal fluorine motif. Journal of the American Chemical Society. 128: 16422-3. PMID 17177350 DOI: 10.1021/Ja066188P |
0.376 |
|
| 2006 |
Gooseman NE, O'Hagan D, Slawin AM, Teale AM, Tozer DJ, Young RJ. The intramolecular beta-fluorine...ammonium interaction in 4- and 8-membered rings. Chemical Communications (Cambridge, England). 3190-2. PMID 17028739 DOI: 10.1039/B606334A |
0.347 |
|
| 2006 |
O'Hagan D, Rzepa HS, Schüler M, Slawin AM. The vicinal difluoro motif: The synthesis and conformation of erythro- and threo- diastereoisomers of 1,2-difluorodiphenylethanes, 2,3-difluorosuccinic acids and their derivatives. Beilstein Journal of Organic Chemistry. 2: 19. PMID 17014729 DOI: 10.1186/1860-5397-2-19 |
0.333 |
|
| 2006 |
Cobb SL, Deng H, McEwan AR, Naismith JH, O'Hagan D, Robinson DA. Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates. Organic & Biomolecular Chemistry. 4: 1458-60. PMID 16604208 DOI: 10.1039/B600574H |
0.347 |
|
| 2006 |
Deng H, Cobb SL, Gee AD, Lockhart A, Martarello L, McGlinchey RP, O'Hagan D, Onega M. Fluorinase mediated C-(18)F bond formation, an enzymatic tool for PET labelling. Chemical Communications (Cambridge, England). 652-4. PMID 16446840 DOI: 10.1039/B516861A |
0.301 |
|
| 2006 |
Deng H, Cobb SL, McEwan AR, McGlinchey RP, Naismith JH, O'Hagan D, Robinson DA, Spencer JB. The fluorinase from Streptomyces cattleya is also a chlorinase. Angewandte Chemie (International Ed. in English). 45: 759-62. PMID 16370017 DOI: 10.1002/Anie.200503582 |
0.36 |
|
| 2006 |
Senn HM, O'Hagan D, Thiel W. Insight into enzymatic C-F bond formation from QM and QM/MM calculations. Journal of the American Chemical Society. 127: 13643-55. PMID 16190730 DOI: 10.1021/Ja053875S |
0.365 |
|
| 2005 |
Schüler M, O'hagan D, Slawin AM. The vicinal F-C-C-F moiety as a tool for influencing peptide conformation. Chemical Communications (Cambridge, England). 4324-6. PMID 16113736 DOI: 10.1039/B506010A |
0.344 |
|
| 2004 |
Cadicamo CD, Courtieu J, Deng H, Meddour A, O'Hagan D. Enzymatic fluorination in Streptomyces cattleya takes place with an inversion of configuration consistent with an SN2 reaction mechanism. Chembiochem : a European Journal of Chemical Biology. 5: 685-90. PMID 15122641 DOI: 10.1002/Cbic.200300839 |
0.323 |
|
| 2004 |
Briggs CR, Allen MJ, O'Hagan D, Tozer DJ, Slawin AM, Goeta AE, Howard JA. The observation of a large gauche preference when 2-fluoroethylamine and 2-fluoroethanol become protonated. Organic & Biomolecular Chemistry. 2: 732-40. PMID 14985814 DOI: 10.1039/B312188G |
0.352 |
|
| 2004 |
Dong C, Huang F, Deng H, Schaffrath C, Spencer JB, O'Hagan D, Naismith JH. Crystal structure and mechanism of a bacterial fluorinating enzyme. Nature. 427: 561-5. PMID 14765200 DOI: 10.1038/Nature02280 |
0.322 |
|
| 2003 |
Dong C, Deng H, Dorward M, Schaffrath C, O'Hagan D, Naismith JH. Crystallization and X-ray diffraction of 5'-fluoro-5'-deoxyadenosine synthase, a fluorination enzyme from Streptomyces cattleya. Acta Crystallographica. Section D, Biological Crystallography. 59: 2292-3. PMID 14646098 DOI: 10.1107/S0907444903019826 |
0.364 |
|
| 2003 |
O'Hagan D, Goss RJ, Meddour A, Courtieu J. Assay for the enantiomeric analysis of [2H1]-fluoroacetic acid: insight into the stereochemical course of fluorination during fluorometabolite biosynthesis in streptomyces cattleya. Journal of the American Chemical Society. 125: 379-87. PMID 12517149 DOI: 10.1021/ja026654k |
0.616 |
|
| 2002 |
Tavasli M, Courtieu J, Goss RJ, Meddour A, O'Hagan D. Extreme enantiomeric discrimination of fluoroalkanes using deuterium NMR in chiral liquid crystalline media. Chemical Communications (Cambridge, England). 844-5. PMID 12123007 DOI: 10.1039/B200992G |
0.597 |
|
| 2002 |
O'Hagan D, Schaffrath C, Cobb SL, Hamilton JT, Murphy CD. Biochemistry: biosynthesis of an organofluorine molecule. Nature. 416: 279. PMID 11907567 DOI: 10.1038/416279A |
0.344 |
|
| 2002 |
Nicoletti M, O'Hagan D, Slawin AMZ. The asymmetric Bischler–Napieralski reaction: preparation of 1,3,4-trisubstituted 1,2,3,4-tetrahydroisoquinolines Journal of the Chemical Society-Perkin Transactions 1. 116-121. DOI: 10.1039/B106942J |
0.319 |
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| 2002 |
Schaffrath C, Cobb SL, O'Hagan D. Cover Picture: Angew. Chem. Int. Ed. 20/2002 Angewandte Chemie International Edition. 41: 3723-3723. DOI: 10.1002/1521-3773(20021018)41:20<3723::Aid-Anie3723>3.0.Co;2-O |
0.33 |
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| 2001 |
Schaffrath C, Murphy CD, Hamilton JTG, O'Hagan D. Biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya. Incorporation of oxygen-18 from [2-2H,2-18O]-glycerol and the role of serine metabolites in fluoroacetaldehyde biosynthesis Journal of the Chemical Society-Perkin Transactions 1. 3100-3105. DOI: 10.1039/B108720G |
0.304 |
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| 2000 |
Batsanov AS, Howard JAK, O'Hagan D, Tavasli M. 1-(1,3-Dithian-2-yl)-2-phenylethanone Acta Crystallographica Section C Crystal Structure Communications. 56: e567-e568. DOI: 10.1107/S0108270100014785 |
0.346 |
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| 2000 |
Batsanov AS, Howard JAK, O'Hagan D, Tavasli M. 3α-Tosyloxymethyltropane(N8–B)borane Acta Crystallographica Section C Crystal Structure Communications. 56: e512-e513. DOI: 10.1107/S0108270100013019 |
0.338 |
|
| 2000 |
O'Hagan D, Royer F, Tavasli M. A synthesis of (S)-α-(fluorodiphenylmethyl)alkylamines by HF–pyridine treatment of 4-alkyl-5,5-diphenyl-oxazolidinones Tetrahedron: Asymmetry. 11: 2033-2036. DOI: 10.1016/S0957-4166(00)00142-7 |
0.319 |
|
| 1999 |
O'Hagan D, Tavasli M. A short synthesis of (S)-α-(diphenylmethyl)alkyl amines from amino acids Tetrahedron: Asymmetry. 10: 1189-1192. DOI: 10.1016/S0957-4166(99)00095-6 |
0.324 |
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| 1998 |
Moore MC, Russell JC, Duffin GR, O'Hagan D. Synthesis and evaluation of a putative acyl tetramic acid intermediate in tenellin biosynthesis in Beauveria bassiana. A new role for tyrosine Tetrahedron. 54: 9195-9206. DOI: 10.1016/S0040-4020(98)00557-2 |
0.319 |
|
| 1998 |
O'Hagan D, Kumadaki I, Petty M, Takaya H, Pearson C. Synthesis and langmuir isotherms of difluorostearic acids Journal of Fluorine Chemistry. 90: 133-138. DOI: 10.1016/S0022-1139(98)00193-6 |
0.307 |
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| 1998 |
O'Hagan D, Parker AH. Enzyme mediated polyester synthesis with the lipase from Candida rugosa Polymer Bulletin. 41: 519-524. DOI: 10.1007/S002890050396 |
0.305 |
|
| 1997 |
O'Hagan D. Pyrrole, pyrrolidine pyridine, piperidine, azepine and tropane alkaloids Natural Product Reports. 14: 637. DOI: 10.1039/Np9971400637 |
0.333 |
|
| 1997 |
Chesters NCJE, O'Hagan D. Biosynthesis of the fungal metabolite, piliformic acid(2-hexylidene-3-methylsuccinic acid) Journal of the Chemical Society-Perkin Transactions 1. 827-834. DOI: 10.1039/A606589I |
0.34 |
|
| 1997 |
Bailey DJ, O'Hagan D, Tavasli M. A short synthesis of (S)-2-(diphenylmethyl) pyrrolidine, a chiral solvating agent for NMR analysis Tetrahedron Asymmetry. 8: 149-153. DOI: 10.1016/S0957-4166(96)00495-8 |
0.337 |
|
| 1997 |
Bridge CF, O'Hagan D. The synthesis of α-fluoroketones by 1,4-additions of mono-fluorinated enamines to Michael acceptors Journal of Fluorine Chemistry. 82: 21-24. DOI: 10.1016/S0022-1139(96)03535-X |
0.306 |
|
| 1996 |
Reineke N, Zaidi NA, Mitra M, O'Hagan D, Batsanov AS, Howard JAK, Naumov DY. A one-step photocatalytic synthesis of 2-(trifluoromethyl)butyrolactones Journal of the Chemical Society-Perkin Transactions 1. 147-150. DOI: 10.1039/P19960000147 |
0.331 |
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| 1996 |
Howard JA, Hoy VJ, O'Hagan D, Smith GT. How good is fluorine as a hydrogen bond acceptor? Tetrahedron. 52: 12613-12622. DOI: 10.1016/0040-4020(96)00749-1 |
0.348 |
|
| 1996 |
Nieschalk J, Batsanov AS, O'Hagan D, Howard J. Synthesis of monofluoro- and difluoro- methylenephosphonate analogues of sn-glycerol-3-phosphate as substrates for glycerol-3-phosphate dehydrogenase and the X-ray structure of the fluoromethylenephosphonate moiety Tetrahedron. 52: 165-176. DOI: 10.1016/0040-4020(95)00890-K |
0.354 |
|
| 1995 |
O'Hagan D, Rogers SV, Duffin GR, Reynolds KA. The biosynthesis of monensin-A: Thymine, β-aminoisobutyrate and methacrylate metabolism in Streptomyces cinnamonensis Journal of Antibiotics. 48: 1280-1287. PMID 8557569 DOI: 10.7164/Antibiotics.48.1280 |
0.303 |
|
| 1995 |
Dasaradhi L, O'Hagan D, Petty MC, Pearson C. Synthesis and characterisation of selectively fluorinated stearic acids (octadecanoic acids) and their tristearins: the effect of introducing one and two fluorine atoms into a hydrocarbon chain Journal of the Chemical Society-Perkin Transactions 1. 221-225. DOI: 10.1039/P29950000221 |
0.337 |
|
| 1995 |
Robins RJ, Chesters NCJE, O'Hagan D, Parr AJ, Walton NJ, Woolley JG. The biosynthesis of hyoscyamine: the process by which littorine rearranges to hyoscyamine Journal of the Chemical Society-Perkin Transactions 1. 481-485. DOI: 10.1039/P19950000481 |
0.311 |
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| 1995 |
Bridge CF, O'Hagan D, Reynolds KA, Wallace KK. Kinetic and stereoelectronic effects of a fluorine substituent on the reaction catalysed by an NADPH-dependent cyclohex-1-enylcarbonyl CoA reductase Journal of the Chemical Society, Chemical Communications. 2329-2330. DOI: 10.1039/C39950002329 |
0.328 |
|
| 1995 |
Nieschalk J, O'Hagan D. Monofluorophosphonates as phosphate mimics in bioorganic chemistry: a comparative study of CH2-, CHF- and CF2-phosphonate analogues of sn-glycerol-3-phosphate as substrates for sn-glycerol-3-phosphate dehydrogenase Journal of the Chemical Society, Chemical Communications. 719-720. DOI: 10.1039/C39950000719 |
0.301 |
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| 1995 |
Chesters NCJE, O'Hagan D, Robins RJ, Kastelle A, Floss HG. The biosynthesis of tropic acid: The stereochemical course of the mutase involved in hyoscyamine biosynthesis in Datura stramonium Journal of the Chemical Society - Series Chemical Communications. 129-130. DOI: 10.1039/C39950000129 |
0.347 |
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| 1995 |
Chesters NCJE, O'hagan D, Robins RJ. The biosynthesis of tropic acid: the (R)-D-phenyllactyl moiety is processed by the mutase involved in hyoscyamine biosynthesis in Datura stramonium Journal of the Chemical Society, Chemical Communications. 127-128. DOI: 10.1039/C39950000127 |
0.303 |
|
| 1995 |
Stabel A, Dasaradhi L, O'Hagan D, Rabe JP. Scanning Tunneling Microscopy Imaging of Single Fluorine Atom Substitution in Stearic Acid Langmuir. 11: 1427-1430. DOI: 10.1021/La00005A003 |
0.31 |
|
| 1995 |
Hübel M, O'Hagan D. Synthesis of trifluoromethyl-containing monomers for the preparation of piezoelectric polymers Liebigs Annalen. 1995: 583-586. DOI: 10.1002/Jlac.199519950379 |
0.304 |
|
| 1994 |
Chesters NCJE, O'Hagan D, Robins RJ. The biosynthesis of tropic acid in plants: evidence for the direct rearrangement of 3-phenyllactate to tropate Journal of the Chemical Society-Perkin Transactions 1. 1159-1162. DOI: 10.1039/P19940001159 |
0.327 |
|
| 1994 |
O'Hagan D, Rzepa HS. Stereospecific control of the citrate synthase mediated synthesis of (2R,3R)-3-fluorocitrate by the relative stabilities of the intermediate fluoroenolates Journal of the Chemical Society, Chemical Communications. 2029-2030. DOI: 10.1039/C39940002029 |
0.308 |
|
| 1993 |
Casher O, O'Hagan D, Rosenkranz CA, Rzepa HS, Zaidi NA. Electronic effects in π-facially stereoselective epoxidation of phenyltrifluoromethylpropenol Journal of the Chemical Society, Chemical Communications. 1337-1340. DOI: 10.1039/C39930001337 |
0.327 |
|
| 1993 |
Mocek U, Zeng Z, O'Hagan D, Zhou P, Fan LDG, Beale JM, Floss HG. Biosynthesis of the modified peptide antibiotic thiostrepton in Streptomyces azureus and Streptomyces laurentii Journal of the American Chemical Society. 115: 7992-8001. DOI: 10.1021/Ja00071A009 |
0.308 |
|
| 1993 |
Dasaradhi L, O'Hagan D. The effect of aryl fluorines in a lipase resolution. Bioorganic & Medicinal Chemistry Letters. 3: 1655-1658. DOI: 10.1016/S0960-894X(00)80036-0 |
0.323 |
|
| 1992 |
O'Hagan D, Zaidi NA. Hydrolytic resolution of tertiary acetylenic acetate esters with the lipase from Candida cylindracea Journal of the Chemical Society-Perkin Transactions 1. 947-949. DOI: 10.1039/P19920000947 |
0.351 |
|
| 1992 |
Meyer J, O'Hagan D. Conversion of fluoropyruvate to fluoroacetate by Dichapetalum cymosum Phytochemistry. 31: 499-501. DOI: 10.1016/0031-9422(92)90024-K |
0.303 |
|
| 1990 |
Chambers RD, O'Hagan D, Lamont RB, Jaina SC. The difluoromethylenephosphonate moiety as a phosphate mimic: X-ray structure of 2-amino-1,1-difluoroethylphosphonic acid Journal of the Chemical Society, Chemical Communications. 1053-1054. DOI: 10.1039/C39900001053 |
0.326 |
|
| 1989 |
Chambers RD, Jaouhari R, O'Hagan D. Fluorine in enzyme chemistry part 2 The preparation of difluoromethylenephosphonate analogues of glycolytic phosphates. Approaching an isosteric and isoelectronic phosphate mimic Tetrahedron. 45: 5101-5108. DOI: 10.1016/S0040-4020(01)81089-9 |
0.321 |
|
| 1989 |
Chambers RD, Jaouhari R, O'Hagan D. Fluorine in enzyme Chemistry: Part 1. Synthesis of difluoromethylenephosphonate derivatives as phosphate mimics Journal of Fluorine Chemistry. 44: 275-284. DOI: 10.1016/S0022-1139(00)83944-5 |
0.352 |
|
| 1989 |
O'Hagan D. Preparation of monofluorocarboxylic acids using N,N-diethyl-1,1.2,3,3,3-hexafluoropropylamine Journal of Fluorine Chemistry. 43: 371-377. DOI: 10.1016/S0022-1139(00)82723-2 |
0.32 |
|
| 1988 |
Reynolds KA, O'Hagan D, Gani D, Robinson JA. Butyrate metabolism in streptomycetes. Characterization of an intramolecular vicinal interchange rearrangement linking isobutyrate and butyrate in Streptomyces cinnamonensis Journal of the Chemical Society, Perkin Transactions 1. 3195-3207. DOI: 10.1039/P19880003195 |
0.317 |
|
| 1985 |
Gani D, O'Hagan D, Reynolds K, Robinson JA. Biosynthesis of the polyether antibiotic monensin-A: Stereochemical aspects of the incorporation and metabolism of isobutyrate Journal of the Chemical Society, Chemical Communications. 1002-1004. DOI: 10.1039/C39850001002 |
0.313 |
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