Steven R. Little - Publications

Affiliations: 
University of Pittsburgh, Pittsburgh, PA, United States 
Area:
chemical engineering, biomedical engineering

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Greene AC, Acharya AP, Lee SB, Gottardi R, Zaleski E, Little SR. Cranberry extract-based formulations for preventing bacterial biofilms. Drug Delivery and Translational Research. PMID 32783154 DOI: 10.1007/S13346-020-00837-X  0.73
2020 Fisher JD, Zhang W, Balmert SC, Aral AM, Acharya AP, Kulahci Y, Li J, Turnquist HR, Thomson AW, Solari MG, Gorantla VS, Little SR. In situ recruitment of regulatory T cells promotes donor-specific tolerance in vascularized composite allotransplantation. Science Advances. 6: eaax8429. PMID 32201714 DOI: 10.1126/Sciadv.Aax8429  0.611
2019 Fisher JD, Balmert SC, Zhang W, Schweizer R, Schnider JT, Komatsu C, Dong L, Erbas VE, Unadkat JV, Aral AM, Acharya AP, Kulahci Y, Turnquist HR, Thomson AW, Solari MG, ... ... Little SR, et al. Treg-inducing microparticles promote donor-specific tolerance in experimental vascularized composite allotransplantation. Proceedings of the National Academy of Sciences of the United States of America. PMID 31792185 DOI: 10.1073/Pnas.1910701116  0.61
2019 Joseph N, Lawson HD, Overholt KJ, Damodaran K, Gottardi R, Acharya AP, Little SR. Synthesis and characterization of CaSr-Metal Organic Frameworks for biodegradable orthopedic applications. Scientific Reports. 9: 13024. PMID 31506530 DOI: 10.1038/S41598-019-49536-9  0.73
2019 Bellotti E, Fedorchak MV, Velankar S, Little SR. Tuning of thermoresponsive pNIPAAm hydrogels for the topical retention of controlled release ocular therapeutics. Journal of Materials Chemistry. B. 7: 1276-1283. PMID 30931126 DOI: 10.1039/C8Tb02976H  0.328
2018 Nichols DA, Sondh IS, Little SR, Zunino P, Gottardi R. Correction to: Design and validation of an osteochondral bioreactor for the screening of treatments for osteoarthritis. Biomedical Microdevices. 20: 39. PMID 29736756 DOI: 10.1007/S10544-018-0283-7  0.613
2018 Ratay ML, Balmert SC, Bassin EJ, Little SR. Controlled Release of an HDAC Inhibitor for Reduction of Inflammation in Dry Eye Disease. Acta Biomaterialia. PMID 29526828 DOI: 10.1016/J.Actbio.2018.03.002  0.345
2018 Fuller TW, Acharya AP, Meyyappan T, Yu M, Bhaskar G, Little SR, Tarin TV. Comparison of Bladder Carcinogens in the Urine of E-cigarette Users Versus Non E-cigarette Using Controls. Scientific Reports. 8: 507. PMID 29323232 DOI: 10.1038/S41598-017-19030-1  0.551
2017 Ratay ML, Balmert SC, Acharya AP, Greene AC, Meyyappan T, Little SR. TRI Microspheres prevent key signs of dry eye disease in a murine, inflammatory model. Scientific Reports. 7: 17527. PMID 29235530 DOI: 10.1038/S41598-017-17869-Y  0.621
2017 Hwang MP, Ding X, Gao J, Acharya AP, Little SR, Wang Y. A biocompatible betaine-functionalized polycation for coacervation. Soft Matter. PMID 29147712 DOI: 10.1039/C7Sm01763D  0.598
2017 Ratay ML, Bellotti E, Gottardi R, Little SR. Modern Therapeutic Approaches for Noninfectious Ocular Diseases Involving Inflammation. Advanced Healthcare Materials. PMID 29034584 DOI: 10.1002/Adhm.201700733  0.654
2017 Acharya AP, Theisen KM, Correa A, Meyyappan T, Apfel A, Sun T, Tarin TV, Little SR. An Inexpensive, Point-of-Care Urine Test for Bladder Cancer in Patients Undergoing Hematuria Evaluation. Advanced Healthcare Materials. PMID 28885787 DOI: 10.1002/Adhm.201700808  0.553
2017 Balmert SC, Donahue C, Vu JR, Erdos G, Falo LD, Little SR. In vivo induction of regulatory T cells promotes allergen tolerance and suppresses allergic contact dermatitis. Journal of Controlled Release : Official Journal of the Controlled Release Society. 261: 223-233. PMID 28694031 DOI: 10.1016/J.Jconrel.2017.07.006  0.351
2017 Bayer EA, Jordan J, Gottardi R, Fedorchak M, Kumta PN, Little S. Programmed Platelet Derived Growth Factor-ββ and Bone Morphogenetic Protein-2 Delivery from a Hybrid Calcium Phosphate/Alginate Scaffold. Tissue Engineering. Part A. PMID 28537482 DOI: 10.1089/ten.TEA.2017.0027  0.659
2017 Ratay ML, Glowacki AJ, Balmert SC, Acharya AP, Polat J, Andrews LP, Fedorchak MV, Schuman JS, Vignali DAA, Little SR. Treg-recruiting microspheres prevent inflammation in a murine model of dry eye disease. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 28501670 DOI: 10.1016/J.Jconrel.2017.05.007  0.628
2017 Fuller T, Acharya A, Bhaskar G, Yu M, Little S, Tarin T. MP88-14 EVALUATION OF E-CIGARETTES USERS URINE FOR KNOWN BLADDER CARCINOGENS Journal of Urology. 197. DOI: 10.1016/J.Juro.2017.02.2739  0.536
2017 Ratay ML, Bellotti E, Gottardi R, Little SR. Ocular Therapeutics: Modern Therapeutic Approaches for Noninfectious Ocular Diseases Involving Inflammation (Adv. Healthcare Mater. 23/2017) Advanced Healthcare Materials. 6: 1770116. DOI: 10.1002/Adhm.201770116  0.647
2016 Bayer EA, Fedorchak MV, Little SR. The Influence of Platelet-Derived Growth Factor and Bone Morphogenetic Protein Presentation on Tubule Organization by Human Umbilical Vascular Endothelial Cells and Human Mesenchymal Stem Cells in Coculture. Tissue Engineering. Part A. 22: 1296-1304. PMID 27650131 DOI: 10.1089/Ten.Tea.2016.0163  0.348
2016 Acharya AP, Sinha M, Ratay ML, Ding X, Balmert SC, Workman CJ, Wang Y, Vignali DAA, Little SR. Localized Multi-Component Delivery Platform Generates Local and Systemic Anti-Tumor Immunity Advanced Functional Materials. 27: 1604366. DOI: 10.1002/Adfm.201604366  0.614
2015 Guaragno ML, Gottardi R, Fedorchak MV, Roy A, Kumta PN, Little SR. One-step synthesis of fluorescently labelled, single-walled carbon nanotubes. Chemical Communications (Cambridge, England). PMID 26458421 DOI: 10.1039/C5Cc05573C  0.631
2015 Acharya AP, Little SR. Stapled endosome disrupting alginate particles for cytosolic delivery of cations. Journal of Drug Targeting. 23: 690-7. PMID 26453164 DOI: 10.3109/1061186X.2015.1048517  0.613
2015 Bayer EA, Gottardi R, Fedorchak MV, Little SR. The scope and sequence of growth factor delivery for vascularized bone tissue regeneration. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 26264834 DOI: 10.1016/J.Jconrel.2015.08.004  0.672
2015 Knab TD, Little SR, Parker RS. A systems approach to modeling drug release from polymer microspheres to accelerate in vitro to in vivo translation. Journal of Controlled Release : Official Journal of the Controlled Release Society. 211: 74-84. PMID 26003043 DOI: 10.1016/J.Jconrel.2015.04.045  0.352
2015 Fisher JD, Acharya AP, Little SR. Micro and nanoparticle drug delivery systems for preventing allotransplant rejection. Clinical Immunology (Orlando, Fla.). PMID 25937032 DOI: 10.1016/J.Clim.2015.04.013  0.609
2015 Glowacki AJ, Gottardi R, Yoshizawa S, Cavalla F, Garlet GP, Sfeir C, Little SR. Strategies to direct the enrichment, expansion, and recruitment of regulatory cells for the treatment of disease. Annals of Biomedical Engineering. 43: 593-602. PMID 25245220 DOI: 10.1007/S10439-014-1125-2  0.669
2014 Garlet GP, Sfeir CS, Little SR. Restoring host-microbe homeostasis via selective chemoattraction of Tregs. Journal of Dental Research. 93: 834-9. PMID 25056995 DOI: 10.1177/0022034514544300  0.302
2014 Fedorchak MV, Conner IP, Medina CA, Wingard JB, Schuman JS, Little SR. 28-day intraocular pressure reduction with a single dose of brimonidine tartrate-loaded microspheres. Experimental Eye Research. 125: 210-6. PMID 24983144 DOI: 10.1016/J.Exer.2014.06.013  0.308
2014 Rothstein SN, Huber KD, Sluis-Cremer N, Little SR. In vitro characterization of a sustained-release formulation for enfuvirtide. Antimicrobial Agents and Chemotherapy. 58: 1797-9. PMID 24366751 DOI: 10.1128/Aac.02440-13  0.314
2014 Mealy JE, Fedorchak MV, Little SR. In vitro characterization of a controlled-release ocular insert for delivery of brimonidine tartrate. Acta Biomaterialia. 10: 87-93. PMID 24080317 DOI: 10.1016/J.Actbio.2013.09.024  0.342
2014 Rothstein SN, Donahue C, Falo LD, Little SR. In silico programming of degradable microparticles to hide and then reveal immunogenic payloads in vivo Journal of Materials Chemistry B. 2: 6183-6187. DOI: 10.1039/C4Tb01042F  0.314
2013 Glowacki AJ, Yoshizawa S, Jhunjhunwala S, Vieira AE, Garlet GP, Sfeir C, Little SR. Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 110: 18525-30. PMID 24167272 DOI: 10.1073/Pnas.1302829110  0.668
2013 Kamalasanan K, Gottardi R, Tan S, Chen Y, Godugu B, Rothstein S, Balazs AC, Star A, Little SR. "Zero-dimensional" single-walled carbon nanotubes. Angewandte Chemie (International Ed. in English). 52: 11308-12. PMID 24038731 DOI: 10.1002/Anie.201305526  0.72
2013 Jhunjhunwala S, Chen LC, Nichols EE, Thomson AW, Raimondi G, Little SR. All-trans retinoic acid and rapamycin synergize with transforming growth factor-β1 to induce regulatory T cells but confer different migratory capacities. Journal of Leukocyte Biology. 94: 981-9. PMID 23898044 DOI: 10.1189/Jlb.0312167  0.644
2012 Rothstein SN, Kay JE, Schopfer FJ, Freeman BA, Little SR. A retrospective mathematical analysis of controlled release design and experimentation. Molecular Pharmaceutics. 9: 3003-11. PMID 23009671 DOI: 10.1021/Mp300388W  0.313
2012 Li J, Rothstein SN, Little SR, Edenborn HM, Meyer TY. The effect of monomer order on the hydrolysis of biodegradable poly(lactic-co-glycolic acid) repeating sequence copolymers. Journal of the American Chemical Society. 134: 16352-9. PMID 22950719 DOI: 10.1021/Ja306866W  0.308
2012 Jhunjhunwala S, Raimondi G, Glowacki AJ, Hall SJ, Maskarinec D, Thorne SH, Thomson AW, Little SR. Bioinspired controlled release of CCL22 recruits regulatory T cells in vivo. Advanced Materials (Deerfield Beach, Fla.). 24: 4735-8. PMID 22821823 DOI: 10.1002/Adma.201202513  0.698
2012 Eghtesad S, Jhunjhunwala S, Little SR, Clemens PR. Effect of rapamycin on immunity induced by vector-mediated dystrophin expression in mdx skeletal muscle. Scientific Reports. 2: 399. PMID 22570764 DOI: 10.1038/Srep00399  0.647
2012 Balmert SC, Little SR. Biomimetic delivery with micro- and nanoparticles. Advanced Materials (Deerfield Beach, Fla.). 24: 3757-78. PMID 22528985 DOI: 10.1002/Adma.201200224  0.337
2012 Jhunjhunwala S, Balmert SC, Raimondi G, Dons E, Nichols EE, Thomson AW, Little SR. Controlled release formulations of IL-2, TGF-β1 and rapamycin for the induction of regulatory T cells. Journal of Controlled Release : Official Journal of the Controlled Release Society. 159: 78-84. PMID 22285546 DOI: 10.1016/J.Jconrel.2012.01.013  0.675
2012 Tengood JE, Maskarinec D, Ridenour R, Little SR. A mathematical model for release of biologics from porous hollow fibers. Journal of Biomedical Materials Research. Part A. 100: 817-26. PMID 22275332 DOI: 10.1002/Jbm.A.34013  0.759
2012 Raimondi G, Jhunjhunwala S, Nichols E, Thomson A, Little S. P158 All-trans retinoic acid and rapamycin synergize with transforming growth factor-B to induce regulatory T cells but confer distinct in vivo migratory capacities Cytokine. 59: 570. DOI: 10.1016/J.Cyto.2012.06.259  0.649
2011 Kamalasanan K, Jhunjhunwala S, Wu J, Swanson A, Gao D, Little SR. Patchy, anisotropic microspheres with soft protein islets. Angewandte Chemie (International Ed. in English). 50: 8706-8. PMID 21809425 DOI: 10.1002/Anie.201101217  0.724
2011 Jhunjhunwala S, Little SR. Microparticulate systems for targeted drug delivery to phagocytes. Cell Cycle (Georgetown, Tex.). 10: 2047-8. PMID 21623160 DOI: 10.4161/Cc.10.13.15713  0.695
2011 Eghtesad S, Jhunjhunwala S, Little SR, Clemens PR. Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle. Molecular Medicine (Cambridge, Mass.). 17: 917-24. PMID 21607286 DOI: 10.2119/Molmed.2010.00256  0.629
2011 Tengood JE, Ridenour R, Brodsky R, Russell AJ, Little SR. Sequential delivery of basic fibroblast growth factor and platelet-derived growth factor for angiogenesis. Tissue Engineering. Part A. 17: 1181-9. PMID 21142700 DOI: 10.1089/Ten.Tea.2010.0551  0.762
2011 Rothstein SN, Little SR. A "tool box" for rational design of degradable controlled release formulations Journal of Materials Chemistry. 21: 29-39. DOI: 10.1039/C0Jm01668C  0.318
2010 Tengood JE, Kovach KM, Vescovi PE, Russell AJ, Little SR. Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis. Biomaterials. 31: 7805-12. PMID 20674008 DOI: 10.1016/J.Biomaterials.2010.07.010  0.755
2010 Kokai LE, Tan H, Jhunjhunwala S, Little SR, Frank JW, Marra KG. Protein bioactivity and polymer orientation is affected by stabilizer incorporation for double-walled microspheres. Journal of Controlled Release : Official Journal of the Controlled Release Society. 141: 168-76. PMID 19751780 DOI: 10.1016/J.Jconrel.2009.09.003  0.677
2009 Jhunjhunwala S, Raimondi G, Thomson AW, Little SR. Delivery of rapamycin to dendritic cells using degradable microparticles. Journal of Controlled Release : Official Journal of the Controlled Release Society. 133: 191-7. PMID 19000726 DOI: 10.1016/J.Jconrel.2008.10.011  0.676
2009 Yadav S, van Vlerken LE, Little SR, Amiji MM. Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells. Cancer Chemotherapy and Pharmacology. 63: 711-22. PMID 18618115 DOI: 10.1007/S00280-008-0790-Y  0.314
2008 van Vlerken LE, Duan Z, Little SR, Seiden MV, Amiji MM. Biodistribution and pharmacokinetic analysis of Paclitaxel and ceramide administered in multifunctional polymer-blend nanoparticles in drug resistant breast cancer model. Molecular Pharmaceutics. 5: 516-26. PMID 18616278 DOI: 10.1021/Mp800030K  0.307
2008 Brito L, Little S, Langer R, Amiji M. Poly(beta-amino ester) and cationic phospholipid-based lipopolyplexes for gene delivery and transfection in human aortic endothelial and smooth muscle cells. Biomacromolecules. 9: 1179-87. PMID 18307309 DOI: 10.1021/Bm7011373  0.445
2008 Raimondi G, Jhunjhunwala S, Thomson AW, Little SR. TARGETED DELIVERY OF RAPAMYCIN TO DENDRITIC CELLS USING BIODEGRADABLE MICROPARTICLES IS HIGHLY EFFECTIVE IN SUPPRESSING THEIR MATURATION AND FUNCTION Transplantation. 86: 640-641. DOI: 10.1097/01.Tp.0000330634.48455.6C  0.664
2008 Little SR, Rothstein SN, Federspiel WJ. A simple model framework for the prediction of controlled release from bulk eroding polymer matrices Journal of Materials Chemistry. 18: 1873-1880. DOI: 10.1039/B718277E  0.301
2008 Little SR, Kohane DS. Polymers for intracellular delivery of nucleic acids Journal of Materials Chemistry. 18: 832-841. DOI: 10.1039/B712930K  0.548
2007 Choleris E, Little SR, Mong JA, Puram SV, Langer R, Pfaff DW. Microparticle-based delivery of oxytocin receptor antisense DNA in the medial amygdala blocks social recognition in female mice. Proceedings of the National Academy of Sciences of the United States of America. 104: 4670-5. PMID 17360582 DOI: 10.1073/Pnas.0700670104  0.349
2006 Zugates GT, Anderson DG, Little SR, Lawhorn IE, Langer R. Synthesis of poly(beta-amino ester)s with thiol-reactive side chains for DNA delivery. Journal of the American Chemical Society. 128: 12726-34. PMID 17002366 DOI: 10.1021/Ja061570N  0.518
2006 Devalapally H, Shenoy D, Little S, Langer R, Amiji M. Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model. Cancer Chemotherapy and Pharmacology. 59: 477-84. PMID 16862429 DOI: 10.1007/S00280-006-0287-5  0.402
2006 Shenoy D, Little S, Langer R, Amiji M. Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs. 1. In vitro evaluations. Molecular Pharmaceutics. 2: 357-66. PMID 16196488 DOI: 10.1021/Mp0500420  0.431
2005 Little SR, Langer R. Nonviral delivery of cancer genetic vaccines. Advances in Biochemical Engineering/Biotechnology. 99: 93-118. PMID 16568889 DOI: 10.1007/10_004  0.397
2005 Shenoy D, Little S, Langer R, Amiji M. Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 2. In vivo distribution and tumor localization studies. Pharmaceutical Research. 22: 2107-14. PMID 16254763 DOI: 10.1007/S11095-005-8343-0  0.403
2005 Wood KC, Little SR, Langer R, Hammond PT. A family of hierarchically self-assembling linear-dendritic hybrid polymers for highly efficient targeted gene delivery. Angewandte Chemie (International Ed. in English). 44: 6704-8. PMID 16173106 DOI: 10.1002/Anie.200502152  0.589
2005 Little SR, Lynn DM, Puram SV, Langer R. Formulation and characterization of poly (beta amino ester) microparticles for genetic vaccine delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. 107: 449-62. PMID 16112767 DOI: 10.1016/J.Jconrel.2005.04.022  0.623
2005 Zugates GT, Little SR, Anderson DG, Langer R. Poly(ß-amino ester)s for DNA delivery Israel Journal of Chemistry. 45: 477-485. DOI: 10.1560/7C67-5X19-Pej8-Pxun  0.541
2004 Haining WN, Anderson DG, Little SR, von Bergwelt-Baildon MS, Cardoso AA, Alves P, Kosmatopoulos K, Nadler LM, Langer R, Kohane DS, von Berwelt-Baildon MS. pH-triggered microparticles for peptide vaccination. Journal of Immunology (Baltimore, Md. : 1950). 173: 2578-85. PMID 15294974 DOI: 10.4049/Jimmunol.173.4.2578  0.625
2004 Little SR, Lynn DM, Ge Q, Anderson DG, Puram SV, Chen J, Eisen HN, Langer R. Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines. Proceedings of the National Academy of Sciences of the United States of America. 101: 9534-9. PMID 15210954 DOI: 10.1073/Pnas.0403549101  0.663
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