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Gerd K Wagner, PhD, FRSC - Publications

Affiliations: 
Pharmacy Albert-Ludwigs-University Freiburg, Freiburg im Breisgau, Baden-Württemberg, Germany 
 2002 Medicinal Chemistry Eberhard Karls Universität Tübingen, Tübingen, Baden-Württemberg, Germany 
 2002-2004 School of Pharmacy University of Bath, Bath, England, United Kingdom 
 2004-2010 School of Pharmacy University of East Anglia, Norwich, England, United Kingdom 
 2010-2019 King's College London, London, UK 
 2019- School of Pharmacy Queen's University Belfast, Belfast, Northern Ireland, United Kingdom 
Area:
chemical biology, medicinal chemistry
Website:
https://scholar.google.com/citations?user=uOLcTywAAAAJ&hl=en
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52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Zähringer S, Rumpf T, Melesina J, Lang AE, Aktories K, Sippl W, Jung M, Wagner GK. Defined stereoisomers of 2″-amino NAD and their activity against human sirtuins and a bacterial (ADP-ribosyl) transferase. Bioorganic & Medicinal Chemistry. 68: 116875. PMID 35716588 DOI: 10.1016/j.bmc.2022.116875  0.714
2020 Metier C, Dow J, Wootton H, Lynham S, Wren B, Wagner GK. Profiling of strain R2866 with carbohydrate-based covalent probes. Organic & Biomolecular Chemistry. PMID 33355321 DOI: 10.1039/d0ob01971b  0.746
2020 Metier CC, Peng J, Xu Y, Wootton H, Riesi V, Lynham S, Zadi S, Turner C, Wand ME, Mark Sutton J, Wagner GK. Profiling protein expression in Klebsiella pneumoniae with a carbohydrate-based covalent probe. Bioorganic & Medicinal Chemistry. 30: 115900. PMID 33352389 DOI: 10.1016/j.bmc.2020.115900  0.741
2020 Métier CC, Wagner GK. Novel disaccharide inhibitors for the bacterial galactosyltransferase LgtC: Design, synthesis via Heyns rearrangement, and biochemical evaluation. Carbohydrate Research. 492: 108017. PMID 32402851 DOI: 10.1016/j.carres.2020.108017  0.785
2018 Ema M, Xu Y, Gehrke S, Wagner GK. Identification of non-substrate-like glycosyltransferase inhibitors from library screening: pitfalls & hits. Medchemcomm. 9: 131-137. PMID 30108907 DOI: 10.1039/C7Md00550D  0.574
2018 Xu Y, Cuccui J, Denman C, Maharjan T, Wren BW, Wagner GK. Structure-activity relationships in a new class of non-substrate-like covalent inhibitors of the bacterial glycosyltransferase LgtC. Bioorganic & Medicinal Chemistry. PMID 29602676 DOI: 10.1016/J.Bmc.2018.03.006  0.545
2018 Xu Y, Uddin N, Wagner GK. Covalent Probes for Carbohydrate-Active Enzymes: From Glycosidases to Glycosyltransferases. Methods in Enzymology. 598: 237-265. PMID 29306437 DOI: 10.1016/Bs.Mie.2017.06.016  0.528
2017 Ming SA, Cottman-Thomas E, Black NC, Chen Y, Veeramachineni V, Peterson DC, Chen X, Tedaldi LM, Wagner GK, Cai C, Linhardt RJ, Vann WF. Interaction of Neisseria meningitidis Group X N-Acetylglucosamine-1-phosphotransferase with Its Donor Substrate. Glycobiology. PMID 29228283 DOI: 10.1093/Glycob/Cwx100  0.375
2017 Collier A, Wagner GK. Base-modified GDP-mannose derivatives and their substrate activity towards a yeast mannosyltransferase. Carbohydrate Research. 452: 91-96. PMID 29080432 DOI: 10.1016/J.Carres.2017.09.010  0.434
2017 Jiang J, Wagner GK. An acceptor analogue of β-1,4-galactosyltransferase: Substrate, inhibitor, or both? Carbohydrate Research. 450: 54-59. PMID 28910600 DOI: 10.1016/J.Carres.2017.08.012  0.781
2017 Xu Y, Smith R, Vivoli M, Ema M, Goos N, Gehrke S, Harmer NJ, Wagner GK. Covalent inhibitors of LgtC: A blueprint for the discovery of non-substrate-like inhibitors for bacterial glycosyltransferases. Bioorganic & Medicinal Chemistry. PMID 28462843 DOI: 10.1016/J.Bmc.2017.04.006  0.778
2016 Pergolizzi G, Wagner GK, Bowater RP. Biochemical and Structural Characterisation of DNA Ligases from Bacteria and Archaea. Bioscience Reports. PMID 27582505 DOI: 10.1042/Bsr20160003  0.354
2016 Kanabar V, Tedaldi L, Jiang J, Nie X, Panina I, Descroix K, Man F, Pitchford SC, Page CP, Wagner GK. Base-modified UDP-sugars reduce cell surface levels of P-selectin glycoprotein 1 (PSGL-1) on IL-1β-stimulated human monocytes. Glycobiology. PMID 27233805 DOI: 10.1093/Glycob/Cww053  0.742
2016 Jiang J, Kanabar V, Padilla B, Man F, Pitchford SC, Page CP, Wagner GK. Uncharged nucleoside inhibitors of β-1,4-galactosyltransferase with activity in cells. Chemical Communications (Cambridge, England). PMID 26882174 DOI: 10.1039/C5Cc09289B  0.783
2015 Wagner GK, Pesnot T, Palcic MM, Jørgensen R. Novel UDP-GalNAc derivative structures provide insight into the donor specificity of human blood group glycosyltransferase. The Journal of Biological Chemistry. PMID 26527682 DOI: 10.1074/Jbc.M115.681262  0.369
2015 Pergolizzi G, Cominetti MM, Butt JN, Field RA, Bowater RP, Wagner GK. Base-modified NAD and AMP derivatives and their activity against bacterial DNA ligases. Organic & Biomolecular Chemistry. 13: 6380-98. PMID 25974621 DOI: 10.1039/C5Ob00294J  0.441
2014 Tedaldi L, Wagner GK. Beyond substrate analogues: new inhibitor chemotypes for glycosyltransferases Medchemcomm. 5: 1106-1125. DOI: 10.1039/C4Md00086B  0.432
2014 Tedaldi L, Evitt A, Göös N, Jiang J, Wagner GK. A practical glycosyltransferase assay for the identification of new inhibitor chemotypes Medchemcomm. 5: 1193-1201. DOI: 10.1039/C4Md00077C  0.702
2013 Pesnot T, Tedaldi LM, Jambrina PG, Rosta E, Wagner GK. Exploring the role of the 5-substituent for the intrinsic fluorescence of 5-aryl and 5-heteroaryl uracil nucleotides: a systematic study. Organic & Biomolecular Chemistry. 11: 6357-71. PMID 23945704 DOI: 10.1039/C3Ob40485D  0.315
2013 Moreau C, Liu Q, Graeff R, Wagner GK, Thomas MP, Swarbrick JM, Shuto S, Lee HC, Hao Q, Potter BV. CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template. Plos One. 8: e66247. PMID 23840430 DOI: 10.1371/Journal.Pone.0066247  0.556
2013 Jørgensen R, Pesnot T, Lee HJ, Palcic MM, Wagner GK. Base-modified donor analogues reveal novel dynamic features of a glycosyltransferase. The Journal of Biological Chemistry. 288: 26201-8. PMID 23836908 DOI: 10.1074/Jbc.M113.465963  0.463
2013 Gehrke SS, Pinto EG, Steverding D, Pleban K, Tempone AG, Hider RC, Wagner GK. Conjugation to 4-aminoquinoline improves the anti-trypanosomal activity of Deferiprone-type iron chelators Bioorganic and Medicinal Chemistry. 21: 805-813. PMID 23266185 DOI: 10.1016/J.Bmc.2012.11.009  0.513
2012 Tedaldi LM, Pierce M, Wagner GK. Optimised chemical synthesis of 5-substituted UDP-sugars and their evaluation as glycosyltransferase inhibitors. Carbohydrate Research. 364: 22-7. PMID 23147042 DOI: 10.1016/J.Carres.2012.10.009  0.42
2012 Evitt A, Tedaldi LM, Wagner GK. One-step synthesis of novel glycosyltransferase inhibitors. Chemical Communications (Cambridge, England). 48: 11856-8. PMID 23125983 DOI: 10.1039/C2Cc36798J  0.403
2012 Steverding D, Sexton DW, Wang X, Gehrke SS, Wagner GK, Caffrey CR. Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target. International Journal For Parasitology. 42: 481-8. PMID 22549023 DOI: 10.1016/J.Ijpara.2012.03.009  0.365
2012 Descroix K, Pesnot T, Yoshimura Y, Gehrke SS, Wakarchuk W, Palcic MM, Wagner GK. Inhibition of galactosyltransferases by a novel class of donor analogues Journal of Medicinal Chemistry. 55: 2015-2024. PMID 22356319 DOI: 10.1021/Jm201154P  0.477
2011 Pergolizzi G, Butt JN, Bowater RP, Wagner GK. A novel fluorescent probe for NAD-consuming enzymes. Chemical Communications (Cambridge, England). 47: 12655-7. PMID 22042207 DOI: 10.1039/C1Cc15499K  0.345
2011 Pesnot T, Kempter J, Schemies J, Pergolizzi G, Uciechowska U, Rumpf T, Sippl W, Jung M, Wagner GK. Two-step synthesis of novel, bioactive derivatives of the ubiquitous cofactor nicotinamide adenine dinucleotide (NAD) Journal of Medicinal Chemistry. 54: 3492-3499. PMID 21528845 DOI: 10.1021/Jm1013852  0.44
2011 Descroix K, Wagner GK. The first C-glycosidic analogue of a novel galactosyltransferase inhibitor. Organic & Biomolecular Chemistry. 9: 1855-63. PMID 21267505 DOI: 10.1039/C0Ob00630K  0.497
2010 Wagner GK, Pesnot T. Glycosyltransferases and their assays. Chembiochem : a European Journal of Chemical Biology. 11: 1939-49. PMID 20672277 DOI: 10.1002/Cbic.201000201  0.405
2010 Pesnot T, Palcic MM, Wagner GK. A novel fluorescent probe for retaining galactosyltransferases. Chembiochem : a European Journal of Chemical Biology. 11: 1392-8. PMID 20533489 DOI: 10.1002/Cbic.201000013  0.461
2010 Niewiadomski S, Beebeejaun Z, Denton H, Smith TK, Morris RJ, Wagner GK. Rationally designed squaryldiamides - a novel class of sugar-nucleotide mimics? Organic & Biomolecular Chemistry. 8: 3488-99. PMID 20532300 DOI: 10.1039/C004165C  0.408
2010 Pesnot T, Jørgensen R, Palcic MM, Wagner GK. Structural and mechanistic basis for a new mode of glycosyltransferase inhibition. Nature Chemical Biology. 6: 321-3. PMID 20364127 DOI: 10.1038/Nchembio.343  0.396
2009 Wagner GK, Pesnot T, Field RA. A survey of chemical methods for sugar-nucleotide synthesis Natural Product Reports. 26: 1172-1194. PMID 19693414 DOI: 10.1039/B909621N  0.399
2009 Kirchberger T, Moreau C, Wagner GK, Fliegert R, Siebrands CC, Nebel M, Schmid F, Harneit A, Odoardi F, Flügel A, Potter BV, Guse AH. 8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist. The Biochemical Journal. 422: 139-49. PMID 19492987 DOI: 10.1042/Bj20082308  0.469
2009 Smith TK, Young BL, Denton H, Hughes DL, Wagner GK. First small molecular inhibitors of T. brucei dolicholphosphate mannose synthase (DPMS), a validated drug target in African sleeping sickness. Bioorganic & Medicinal Chemistry Letters. 19: 1749-52. PMID 19217283 DOI: 10.1016/J.Bmcl.2009.01.083  0.382
2008 Pesnot T, Wagner GK. Novel derivatives of UDP-glucose: concise synthesis and fluorescent properties. Organic & Biomolecular Chemistry. 6: 2884-91. PMID 18688480 DOI: 10.1039/B805216F  0.32
2008 Zhang B, Wagner GK, Weber K, Garnham C, Morgan AJ, Galione A, Guse AH, Potter BV. 2'-deoxy cyclic adenosine 5'-diphosphate ribose derivatives: importance of the 2'-hydroxyl motif for the antagonistic activity of 8-substituted cADPR derivatives. Journal of Medicinal Chemistry. 51: 1623-36. PMID 18303825 DOI: 10.1021/Jm7010386  0.545
2006 Kirchberger T, Wagner G, Xu J, Cordiglieri C, Wang P, Gasser A, Fliegert R, Bruhn S, Flügel A, Lund FE, Zhang LH, Potter BV, Guse AH. Cellular effects and metabolic stability of N1-cyclic inosine diphosphoribose and its derivatives. British Journal of Pharmacology. 149: 337-44. PMID 16967053 DOI: 10.1038/Sj.Bjp.0706869  0.529
2006 Moreau C, Wagner GK, Weber K, Guse AH, Potter BV. Structural determinants for N1/N7 cyclization of nicotinamide hypoxanthine 5'-dinucleotide (NHD+) derivatives by ADP-ribosyl cyclase from aplysia californica: Ca2+-mobilizing activity of 8-substituted cyclic inosine 5'-diphosphoribose analogues in T-lymphocytes. Journal of Medicinal Chemistry. 49: 5162-76. PMID 16913705 DOI: 10.1021/Jm060275A  0.543
2006 Peifer C, Wagner G, Laufer S. New approaches to the treatment of inflammatory disorders small molecule inhibitors of p38 MAP kinase Current Topics in Medicinal Chemistry. 6: 113-149. PMID 16454763 DOI: 10.2174/156802606775270323  0.539
2006 Wagner G, Laufer S. Small molecular anti-cytokine agents Medicinal Research Reviews. 26: 1-62. PMID 16283677 DOI: 10.1002/Med.20042  0.571
2006 Wagner G, Laufer S. Small Molecular anti-Cytokine Agents Cheminform. 37. DOI: 10.1002/CHIN.200619241  0.383
2005 Wagner GK, Guse AH, Potter BV. Rapid synthetic route toward structurally modified derivatives of cyclic adenosine 5'-diphosphate ribose. The Journal of Organic Chemistry. 70: 4810-9. PMID 15932322 DOI: 10.1021/Jo050085S  0.522
2003 Wagner GK, Riley AM, Rosenberg HJ, Taylor CW, Guse AH, Potter BV. Analogues of cyclic adenosine 5'-diphosphate ribose and adenophostin A, nucleotides in cellular signal transduction. Nucleic Acids Research. Supplement (2001). 1-2. PMID 14510350  0.496
2003 Wagner GK, Black S, Guse AH, Potter BV. First enzymatic synthesis of an N1-cyclised cADPR (cyclic-ADP ribose) analogue with a hypoxanthine partial structure: discovery of a membrane permeant cADPR agonist. Chemical Communications (Cambridge, England). 1944-5. PMID 12932045 DOI: 10.1039/B305660K  0.497
2003 Laufer SA, Wagner GK, Kotschenreuther DA, Albrecht W. Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. Journal of Medicinal Chemistry. 46: 3230-44. PMID 12852754 DOI: 10.1021/Jm030766K  0.533
2003 Wagner GK, Kotschenreuther D, Zimmermann W, Laufer SA. Identification of regioisomers in a series of N-substituted pyridin-4-yl imidazole derivatives by regiospecific synthesis, GC/MS, and 1H NMR. The Journal of Organic Chemistry. 68: 4527-30. PMID 12762762 DOI: 10.1021/Jo026619W  0.541
2002 Laufer SA, Striegel HG, Wagner GK. Imidazole inhibitors of cytokine release: probing substituents in the 2 position. Journal of Medicinal Chemistry. 45: 4695-705. PMID 12361396 DOI: 10.1021/Jm020873Z  0.502
2002 Laufer S, Wagner G, Kotschenreuther D. Ones, thiones, and N-oxides: An eercise in imidazole chemistry Angewandte Chemie - International Edition. 41: 2290-2293. PMID 12203569 DOI: 10.1002/1521-3773(20020703)41:13<2290::Aid-Anie2290>3.0.Co;2-R  0.52
2002 Laufer SA, Wagner GK. From imidazoles to pyrimidines: New inhibitors of cytokine release Journal of Medicinal Chemistry. 45: 2733-2740. PMID 12061876 DOI: 10.1021/Jm011098A  0.561
2002 Klaas CA, Wagner G, Laufer S, Sosa S, Della Loggia R, Bomme U, Pahl HL, Merfort I. Studies on the anti-inflammatory activity of phytopharmaceuticals prepared from Arnica flowers. Planta Medica. 68: 385-91. PMID 12058311 DOI: 10.1055/S-2002-32067  0.475
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