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Hao Wu - Publications

Affiliations: 
Biological Chemistry and Molecular Pharmacology Harvard Medical School, Boston, MA, United States 
Area:
structural immunology
Website:
http://www.fas.harvard.edu/~biophys/Hao_Wu.htm
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121 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Fu J, Schroder K, Wu H. Mechanistic insights from inflammasome structures. Nature Reviews. Immunology. PMID 38374299 DOI: 10.1038/s41577-024-00995-w  0.334
2024 Li R, Zan Y, Wang D, Chen X, Wang A, Tan H, Zhang G, Ding S, Shen C, Wu H, Zhu S. A mouse model to distinguish NLRP6-mediated inflammasome-dependent and -independent functions. Proceedings of the National Academy of Sciences of the United States of America. 121: e2321419121. PMID 38289959 DOI: 10.1073/pnas.2321419121  0.301
2023 Du G, Healy LB, David L, Walker C, Fontana P, Dong Y, Devant P, Puthenveetil R, Ficarro SB, Banerjee A, Kagan JC, Lieberman J, Wu H. ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation. Biorxiv : the Preprint Server For Biology. PMID 36945424 DOI: 10.1101/2023.03.07.531538  0.3
2023 Paidimuddala B, Cao J, Nash G, Xie Q, Wu H, Zhang L. Mechanism of NAIP-NLRC4 inflammasome activation revealed by cryo-EM structure of unliganded NAIP5. Nature Structural & Molecular Biology. PMID 36604500 DOI: 10.1038/s41594-022-00889-2  0.319
2022 Fu J, Wu H. Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation. Annual Review of Immunology. PMID 36750315 DOI: 10.1146/annurev-immunol-081022-021207  0.327
2022 Xiao L, Magupalli VG, Wu H. Cryo-EM structures of the active NLRP3 inflammasome disk. Nature. PMID 36442502 DOI: 10.1038/s41586-022-05570-8  0.329
2022 Fontana P, Dong Y, Pi X, Tong AB, Hecksel CW, Wang L, Fu TM, Bustamante C, Wu H. Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold. Science (New York, N.Y.). 376: eabm9326. PMID 35679401 DOI: 10.1126/science.abm9326  0.699
2022 Zheng W, Shen C, Wang L, Rawson S, Xie WJ, Nist-Lund C, Wu J, Shen Z, Xia S, Holt JR, Wu H, Fu TM. pH regulates potassium conductance and drives a constitutive proton current in human TMEM175. Science Advances. 8: eabm1568. PMID 35333573 DOI: 10.1126/sciadv.abm1568  0.644
2022 Xiong X, Tian S, Yang P, Lebreton F, Bao H, Sheng K, Yin L, Chen P, Zhang J, Qi W, Ruan J, Wu H, Chen H, Breault DT, Wu H, et al. Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors. Cell. PMID 35259335 DOI: 10.1016/j.cell.2022.02.002  0.696
2022 Vora SM, Fontana P, Mao T, Leger V, Zhang Y, Fu TM, Lieberman J, Gehrke L, Shi M, Wang L, Iwasaki A, Wu H. Targeting stem-loop 1 of the SARS-CoV-2 5' UTR to suppress viral translation and Nsp1 evasion. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35149555 DOI: 10.1073/pnas.2117198119  0.679
2021 Shen C, Li R, Negro R, Cheng J, Vora SM, Fu TM, Wang A, He K, Andreeva L, Gao P, Tian Z, Flavell RA, Zhu S, Wu H. Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome. Cell. PMID 34678144 DOI: 10.1016/j.cell.2021.09.032  0.706
2021 Gao W, Li Y, Liu X, Wang S, Mei P, Chen Z, Liu K, Li S, Xu XW, Gan J, Wu J, Ji C, Ding C, Liu X, Lai Y, ... ... Wu H, et al. TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization. Cell Death and Differentiation. PMID 34511601 DOI: 10.1038/s41418-021-00867-z  0.664
2021 Yang Q, Li J, Zhang Z, Wu X, Liao T, Yu S, You Z, Hou X, Ye J, Liu G, Ma S, Xie G, Zhou Y, Li M, Wu M, ... ... Wu H, ... ... Wu H, et al. Clinical characteristics and a decision tree model to predict death outcome in severe COVID-19 patients. Bmc Infectious Diseases. 21: 783. PMID 34372767 DOI: 10.1186/s12879-021-06478-w  0.56
2021 Zhou Y, Yang Q, Ye J, Wu X, Hou X, Feng Y, Luo B, Li J, Yang G, Li L, Yang X, Wang B, Zhao S, Li L, Li Q, ... ... Wu H, et al. Clinical features and death risk factors in COVID-19 patients with cancer: a retrospective study. Bmc Infectious Diseases. 21: 760. PMID 34353293 DOI: 10.1186/s12879-021-06495-9  0.555
2021 Zhu L, Xie H, Liu Q, Ma F, Wu H. Klotho inhibits H O -induced oxidative stress and apoptosis in periodontal ligament stem cells by regulating UCP2 expression. Clinical and Experimental Pharmacology & Physiology. PMID 34174105 DOI: 10.1111/1440-1681.13547  0.382
2021 Zhu L, Xie H, Liu Q, Ma F, Wu H. Klotho inhibits H O -induced oxidative stress and apoptosis in periodontal ligament stem cells by regulating UCP2 expression. Clinical and Experimental Pharmacology & Physiology. PMID 34174105 DOI: 10.1111/1440-1681.13547  0.382
2021 Wang L, Sharif H, Vora SM, Zheng Y, Wu H. Structures and functions of the inflammasome engine. The Journal of Allergy and Clinical Immunology. 147: 2021-2029. PMID 34092352 DOI: 10.1016/j.jaci.2021.04.018  0.568
2021 Sharif H, Hollingsworth LR, Griswold AR, Hsiao JC, Wang Q, Bachovchin DA, Wu H. Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment. Immunity. PMID 34019797 DOI: 10.1016/j.immuni.2021.04.024  0.583
2021 Xia S, Zhang Z, Magupalli VG, Pablo JL, Dong Y, Vora SM, Wang L, Fu TM, Jacobson MP, Greka A, Lieberman J, Ruan J, Wu H. Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature. PMID 33883744 DOI: 10.1038/s41586-021-03478-3  0.778
2021 Guo JC, Xie H, Wu H, Tong TJ. [Efficacy of curcumin in the treatment of oral submucous fibrosis: a Meta-analysis]. Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal of Stomatology. 39: 195-202. PMID 33834675 DOI: 10.7518/hxkq.2021.02.011  0.317
2021 Hollingsworth LR, Sharif H, Griswold AR, Fontana P, Mintseris J, Dagbay KB, Paulo JA, Gygi SP, Bachovchin DA, Wu H. DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Nature. PMID 33731932 DOI: 10.1038/s41586-021-03350-4  0.609
2021 Wang L, Chen Z, Wu H, Fu TM. Purification and cryoelectron microscopy structure determination of human V-ATPase. Star Protocols. 2: 100350. PMID 33665630 DOI: 10.1016/j.xpro.2021.100350  0.668
2021 Robert Hollingsworth L, David L, Li Y, Griswold AR, Ruan J, Sharif H, Fontana P, Orth-He EL, Fu TM, Bachovchin DA, Wu H. Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nature Communications. 12: 189. PMID 33420033 DOI: 10.1038/s41467-020-20320-y  0.806
2020 Guo J, Xie H, Wu H, Liang M. Efficacy of Lycopene in the Treatment of Oral Submucous Fibrosis: A Meta-analysis of Randomized Controlled Trials. The Journal of Evidence-Based Dental Practice. 20: 101471. PMID 33303091 DOI: 10.1016/j.jebdp.2020.101471  0.311
2020 Guo J, Xie H, Wu H. Preventive Measures for COVID-19 in Dental Treatments. Disaster Medicine and Public Health Preparedness. 1-13. PMID 33092676 DOI: 10.1017/dmp.2020.409  0.316
2020 Wang L, Wu D, Robinson CV, Wu H, Fu TM. Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly. Molecular Cell. PMID 33065002 DOI: 10.1016/j.molcel.2020.09.029  0.685
2020 Shi M, Wang L, Fontana P, Vora S, Zhang Y, Fu TM, Lieberman J, Wu H. SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism. Biorxiv : the Preprint Server For Biology. PMID 32995777 DOI: 10.1101/2020.09.18.302901  0.676
2020 Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, ... ... Wu H, et al. HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science (New York, N.Y.). 369. PMID 32943500 DOI: 10.1126/Science.Aas8995  0.807
2020 Zang Z, Lv Y, Liu S, Yang W, Ci J, Ren X, Wang Z, Wu H, Ma W, Jiang L, Yang W. A Novel ERF Transcription Factor, , Positively Regulates Maize Resistance to . Frontiers in Plant Science. 11: 850. PMID 32612628 DOI: 10.3389/fpls.2020.00850  0.319
2020 Guo J, Xie H, Liang M, Wu H. COVID-19: a novel coronavirus and a novel challenge for oral healthcare. Clinical Oral Investigations. PMID 32382932 DOI: 10.1007/s00784-020-03291-8  0.31
2020 Hu JJ, Liu X, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, ... ... Wu H, et al. FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nature Immunology. PMID 32367036 DOI: 10.1038/S41590-020-0669-6  0.723
2020 Sadek J, Wuo MG, Rooklin D, Hauenstein A, Hong SH, Gautam A, Wu H, Zhang Y, Cesarman E, Arora PS. Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics. Nature Communications. 11: 1786. PMID 32286300 DOI: 10.1038/S41467-020-15576-3  0.798
2020 Guo J, Xie H, Mao S, Liang M, Wu H. Efficacy of hyaluronidase combined with corticosteroids in treatment of oral submucous fibrosis: a meta-analysis of randomised controlled clinical trials. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. PMID 32145110 DOI: 10.1111/jop.13009  0.314
2019 Xia S, Ruan J, Wu H. Monitoring gasdermin pore formation in vitro. Methods in Enzymology. 625: 95-107. PMID 31455540 DOI: 10.1016/bs.mie.2019.04.024  0.747
2019 Xia S, Hollingsworth LR, Wu H. Mechanism and Regulation of Gasdermin-Mediated Cell Death. Cold Spring Harbor Perspectives in Biology. PMID 31451512 DOI: 10.1101/cshperspect.a036400  0.314
2019 Wu H, Arnold E. Michael G. Rossmann (1930-2019). Nature Structural & Molecular Biology. PMID 31285606 DOI: 10.1038/S41594-019-0271-5  0.49
2019 Xie H, Guo J, Tan B, Wu H. Efficacy of Salvia miltiorrhiza injection combined with steroids in the treatment of oral submucous fibrosis: A meta-analysis of randomized controlled trials. Medicine. 98: e16339. PMID 31277186 DOI: 10.1097/MD.0000000000016339  0.316
2019 Arnold E, Wu H, Johnson JE. Michael G. Rossmann (1930-2019), pioneer in macromolecular and virus crystallography: scientist, mentor and friend. Acta Crystallographica. Section D, Structural Biology. 75: 523-527. PMID 31205014 DOI: 10.1107/S2059798319008398  0.646
2019 Sharif H, Wang L, Wang WL, Magupalli VG, Andreeva L, Qiao Q, Hauenstein AV, Wu Z, Núñez G, Mao Y, Wu H. Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. Nature. PMID 31189953 DOI: 10.1038/S41586-019-1295-Z  0.817
2019 Xia S, Wang L, Fu TM, Wu H. Mechanism of TRPM2 channel gating revealed by cryo-EM. The Febs Journal. PMID 31144442 DOI: 10.1111/febs.14939  0.676
2019 Shen C, Sharif H, Xia S, Wu H. Structural and mechanistic elucidation of inflammasome signaling by cryo-EM. Current Opinion in Structural Biology. 58: 18-25. PMID 31128494 DOI: 10.1016/J.Sbi.2019.03.033  0.575
2019 Lee YR, Chen M, Lee JD, Zhang J, Lin SY, Fu TM, Chen H, Ishikawa T, Chiang SY, Katon J, Zhang Y, Shulga YV, Bester AC, Fung J, Monteleone E, ... Wu H, et al. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science (New York, N.Y.). 364. PMID 31097636 DOI: 10.1126/Science.Aau0159  0.675
2019 Choi YJ, Kim S, Choi Y, Nielsen TB, Yan J, Lu A, Ruan J, Lee HR, Wu H, Spellberg B, Jung JU. Publisher Correction: SERPINB1-mediated checkpoint of inflammatory caspase activation. Nature Immunology. PMID 30846880 DOI: 10.1038/s41590-019-0361-x  0.668
2019 Pan L, Fu TM, Zhao W, Zhao L, Chen W, Qiu C, Liu W, Liu Z, Piai A, Fu Q, Chen S, Wu H, Chou JJ. Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling. Cell. PMID 30827683 DOI: 10.1016/j.cell.2019.02.001  0.707
2019 Choi YJ, Kim S, Choi Y, Nielsen TB, Yan J, Lu A, Ruan J, Lee HR, Wu H, Spellberg B, Jung JU. SERPINB1-mediated checkpoint of inflammatory caspase activation. Nature Immunology. PMID 30692621 DOI: 10.1038/s41590-018-0303-z  0.748
2019 Shen C, Lu A, Xie WJ, Ruan J, Negro R, Egelman EH, Fu TM, Wu H. Molecular mechanism for NLRP6 inflammasome assembly and activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30674671 DOI: 10.2210/Pdb6Ndj/Pdb  0.823
2018 Wang L, Fu TM, Zhou Y, Xia S, Greka A, Wu H. Structures and gating mechanism of human TRPM2. Science (New York, N.Y.). PMID 30467180 DOI: 10.1126/Science.Aav4809  0.684
2018 Luong PH, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI. INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. Elife. 7. PMID 30355448 DOI: 10.7554/Elife.38539  0.704
2018 Li Y, Fu TM, Lu A, Witt K, Ruan J, Shen C, Wu H. Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1. Proceedings of the National Academy of Sciences of the United States of America. PMID 30279182 DOI: 10.1073/pnas.1810524115  0.832
2018 Ruan J, Xia S, Liu X, Lieberman J, Wu H. Cryo-EM structure of the gasdermin A3 membrane pore. Nature. PMID 29695864 DOI: 10.1038/s41586-018-0058-6  0.72
2018 Mompeán M, Li W, Li J, Laage S, Siemer AB, Bozkurt G, Wu H, McDermott AE. The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex. Cell. PMID 29681455 DOI: 10.1016/J.Cell.2018.03.032  0.654
2018 Annibaldi A, Wicky John S, Vanden Berghe T, Swatek KN, Ruan J, Liccardi G, Bianchi K, Elliott PR, Choi SM, Van Coillie S, Bertin J, Wu H, Komander D, Vandenabeele P, Silke J, et al. Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2. Molecular Cell. 69: 566-580.e5. PMID 29452637 DOI: 10.1016/J.Molcel.2018.01.027  0.725
2018 Xia S, Fu TM, Wu H. Inflammation NODs to Antagonists of RIP2-XIAP Interaction. Molecular Cell. 69: 535-536. PMID 29452633 DOI: 10.1016/j.molcel.2018.02.003  0.694
2018 Fu TM, Shen C, Li Q, Zhang P, Wu H. Mechanism of ubiquitin transfer promoted by TRAF6. Proceedings of the National Academy of Sciences of the United States of America. PMID 29432170 DOI: 10.1073/pnas.1721788115  0.704
2018 David L, Li Y, Ma J, Garner E, Zhang X, Wu H. Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome. Proceedings of the National Academy of Sciences of the United States of America. PMID 29382759 DOI: 10.1073/pnas.1721967115  0.331
2017 Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC. The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages. Immunity. PMID 29195811 DOI: 10.1016/J.Immuni.2017.11.013  0.707
2017 Hauenstein AV, Xu G, Kabaleeswaran V, Wu H. Evidence for M1-linked Polyubiquitin-Mediated Conformational Change in NEMO. Journal of Molecular Biology. PMID 29111346 DOI: 10.1016/J.Jmb.2017.10.026  0.799
2017 Kleino A, Ramia NF, Bozkurt G, Shen Y, Nailwal H, Huang J, Napetschnig J, Gangloff M, Chan FK, Wu H, Li J, Silverman N. Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling. Immunity. 47: 635-647.e6. PMID 29045898 DOI: 10.1016/J.Immuni.2017.09.011  0.663
2017 Sharif H, Li Y, Dong Y, Dong L, Wang WL, Mao Y, Wu H. Cryo-EM structure of the DNA-PK holoenzyme. Proceedings of the National Academy of Sciences of the United States of America. PMID 28652322 DOI: 10.1073/Pnas.1707386114  0.509
2017 Lamour G, Nassar R, Chan PH, Bozkurt G, Li J, Bui JM, Yip CK, Mayor T, Li H, Wu H, Gsponer JA. Mapping the Broad Structural and Mechanical Properties of Amyloid Fibrils. Biophysical Journal. 112: 584-594. PMID 28256219 DOI: 10.1016/J.Bpj.2016.12.036  0.602
2016 Fu TM, Li Y, Lu A, Li Z, Vajjhala PR, Cruz AC, Srivastava DB, DiMaio F, Penczek PA, Siegel RM, Stacey KJ, Egelman EH, Wu H. Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex. Molecular Cell. PMID 27746017 DOI: 10.1016/J.Molcel.2016.09.009  0.751
2016 Wang H, Horbinski C, Wu H, Liu Y, Sheng S, Liu J, Weiss H, Stromberg AJ, Wang C. NanoStringDiff: a novel statistical method for differential expression analysis based on NanoString nCounter data. Nucleic Acids Research. PMID 27471031 DOI: 10.1093/Nar/Gkw677  0.5
2016 Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H, Lieberman J. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature. 535: 153-158. PMID 27383986 DOI: 10.1038/Nature18629  0.733
2016 Zanoni I, Tan Y, Di Gioia M, Broggi A, Ruan J, Shi J, Donado CA, Shao F, Wu H, Springstead JR, Kagan JC. An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells. Science (New York, N.Y.). PMID 27103670 DOI: 10.1126/Science.Aaf3036  0.731
2016 Schmidt FI, Lu A, Chen JW, Ruan J, Tang C, Wu H, Ploegh HL. A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly. The Journal of Experimental Medicine. PMID 27069117 DOI: 10.1084/Jem.20151790  0.754
2016 Lu A, Li Y, Schmidt FI, Yin Q, Chen S, Fu TM, Tong AB, Ploegh HL, Mao Y, Wu H. Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism. Nature Structural & Molecular Biology. PMID 27043298 DOI: 10.1038/Nsmb.3199  0.813
2016 Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, ... ... Wu H, et al. Data publication with the structural biology data grid supports live analysis. Nature Communications. 7: 10882. PMID 26947396 DOI: 10.1038/Ncomms10882  0.499
2016 Fu Q, Fu TM, Cruz AC, Sengupta P, Thomas SK, Wang S, Siegel RM, Wu H, Chou JJ. Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor. Molecular Cell. PMID 26853147 DOI: 10.1016/J.Molcel.2016.01.009  0.738
2015 Lu A, Li Y, Yin Q, Ruan J, Yu X, Egelman E, Wu H. Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2. Cell Discovery. 1. PMID 26583071 DOI: 10.1038/celldisc.2015.13  0.78
2015 Ru H, Chambers MG, Fu TM, Tong AB, Liao M, Wu H. Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures. Cell. PMID 26548953 DOI: 10.1016/J.Cell.2015.10.055  0.685
2015 Vajjhala PR, Lu A, Brown DL, Pang SW, Sagulenko V, Sester DP, Cridland SO, Hill JM, Schroder K, Stow JL, Wu H, Stacey KJ. The inflammasome adaptor ASC induces procaspase-8 death effector domain filaments. The Journal of Biological Chemistry. PMID 26468282 DOI: 10.1074/jbc.M115.687731  0.304
2015 Zhang L, Chen S, Ruan J, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL, Marks C, Ouyang Q, Zhang X, Mao Y, Wu H. Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization. Science (New York, N.Y.). PMID 26449474 DOI: 10.1126/science.aac5789  0.799
2015 Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ. Erratum: Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nature Chemical Biology. 11: 741. PMID 26284675 DOI: 10.1038/Nchembio0915-741C  0.465
2015 Hauenstein AV, Zhang L, Wu H. The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines. Current Opinion in Structural Biology. 31: 75-83. PMID 25881155 DOI: 10.1016/J.Sbi.2015.03.014  0.823
2015 Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ. Corrigendum: Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nature Chemical Biology. 11: 235. PMID 25689338 DOI: 10.1038/Nchembio0315-235D  0.47
2015 Chen L, Wang C, Qin ZS, Wu H. A novel statistical method for quantitative comparison of multiple ChIP-seq datasets. Bioinformatics (Oxford, England). 31: 1889-96. PMID 25682068 DOI: 10.1093/bioinformatics/btv094  0.514
2015 Yin Q, Fu TM, Li J, Wu H. Structural biology of innate immunity. Annual Review of Immunology. 33: 393-416. PMID 25622194 DOI: 10.1146/Annurev-Immunol-032414-112258  0.806
2015 Lu A, Wu H. Structural mechanisms of inflammasome assembly Febs Journal. 282: 435-444. PMID 25354325 DOI: 10.1111/febs.13133  0.332
2015 Wu H, Wang C, Wu Z. PROPER: comprehensive power evaluation for differential expression using RNA-seq. Bioinformatics (Oxford, England). 31: 233-41. PMID 25273110 DOI: 10.1093/Bioinformatics/Btu640  0.491
2014 Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ. Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nature Chemical Biology. 10: 1043-8. PMID 25344812 DOI: 10.1038/Nchembio.1661  0.552
2014 Ferrao R, Zhou H, Shan Y, Liu Q, Li Q, Shaw DE, Li X, Wu H. IRAK4 dimerization and trans-autophosphorylation are induced by Myddosome assembly. Molecular Cell. 55: 891-903. PMID 25201411 DOI: 10.1016/J.Molcel.2014.08.006  0.301
2014 Jang TH, Zheng C, Li J, Richards C, Hsiao YS, Walz T, Wu H, Park HH. Structural study of the RIPoptosome core reveals a helical assembly for kinase recruitment. Biochemistry. 53: 5424-31. PMID 25119434 DOI: 10.1021/Bi500585U  0.692
2014 Wu H, Williams J, Nathans J. Complete morphologies of basal forebrain cholinergic neurons in the mouse. Elife. 3: e02444. PMID 24894464 DOI: 10.7554/Elife.02444  0.393
2014 Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, Vos MR, Schröder GF, Fitzgerald KA, Wu H, Egelman EH. Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell. 156: 1193-206. PMID 24630722 DOI: 10.1016/J.Cell.2014.02.008  0.802
2014 Lu A, Kabaleeswaran V, Fu T, Magupalli VG, Wu H. Crystal Structure of the F27G AIM2 PYD Mutant and Similarities of its Self-association to DED/DED Interactions Journal of Molecular Biology. 426: 1420-1427. PMID 24406744 DOI: 10.1016/J.Jmb.2013.12.029  0.738
2013 Qiao Q, Yang C, Zheng C, Fontán L, David L, Yu X, Bracken C, Rosen M, Melnick A, Egelman EH, Wu H. Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly. Molecular Cell. 51: 766-79. PMID 24074955 DOI: 10.1016/J.Molcel.2013.08.032  0.327
2013 Li J, Yin Q, Wu H. Structural basis of signal transduction in the TNF receptor superfamily. Advances in Immunology. 119: 135-53. PMID 23886067 DOI: 10.1016/B978-0-12-407707-2.00005-9  0.736
2013 Yin Q, Sester DP, Tian Y, Hsiao YS, Lu A, Cridland JA, Sagulenko V, Thygesen SJ, Choubey D, Hornung V, Walz T, Stacey KJ, Wu H. Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation. Cell Reports. 4: 327-39. PMID 23850291 DOI: 10.1016/J.Celrep.2013.06.024  0.601
2013 Lee JH, Yi L, Li J, Schweitzer K, Borgmann M, Naumann M, Wu H. Crystal structure and versatile functional roles of the COP9 signalosome subunit 1. Proceedings of the National Academy of Sciences of the United States of America. 110: 11845-50. PMID 23818606 DOI: 10.1073/Pnas.1302418110  0.676
2013 Kim S, Li L, Maliga Z, Yin Q, Wu H, Mitchison TJ. Anticancer flavonoids are mouse-selective STING agonists. Acs Chemical Biology. 8: 1396-401. PMID 23683494 DOI: 10.1021/Cb400264N  0.569
2013 Lu TT, Onizawa M, Hammer GE, Turer EE, Yin Q, Damko E, Agelidis A, Shifrin N, Advincula R, Barrera J, Malynn BA, Wu H, Ma A. Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. Immunity. 38: 896-905. PMID 23602765 DOI: 10.1016/J.Immuni.2013.03.008  0.519
2013 Wu H, Wang C, Wu Z. A new shrinkage estimator for dispersion improves differential expression detection in RNA-seq data. Biostatistics (Oxford, England). 14: 232-43. PMID 23001152 DOI: 10.1093/Biostatistics/Kxs033  0.497
2012 Wu H, Williams J, Nathans J. Morphologic diversity of cutaneous sensory afferents revealed by genetically directed sparse labeling. Elife. 1: e00181. PMID 23256042 DOI: 10.7554/Elife.00181  0.421
2012 Li J, McQuade T, Siemer AB, Napetschnig J, Moriwaki K, Hsiao YS, Damko E, Moquin D, Walz T, McDermott A, Chan FK, Wu H. The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell. 150: 339-50. PMID 22817896 DOI: 10.1016/J.Cell.2012.06.019  0.646
2012 Yin Q, Tian Y, Kabaleeswaran V, Jiang X, Tu D, Eck MJ, Chen ZJ, Wu H. Cyclic di-GMP sensing via the innate immune signaling protein STING. Molecular Cell. 46: 735-45. PMID 22705373 DOI: 10.1016/J.Molcel.2012.05.029  0.691
2012 Ferrao R, Li J, Bergamin E, Wu H. Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamily. Science Signaling. 5: re3. PMID 22649099 DOI: 10.1126/Scisignal.2003124  0.653
2012 Ferrao R, Wu H. Helical assembly in the death domain (DD) superfamily Current Opinion in Structural Biology. 22: 241-247. PMID 22429337 DOI: 10.1016/J.Sbi.2012.02.006  0.3
2011 Wu H, Lo YC, Yin Q. Structural studies of NEMO and TRAF6: implications in NF-κB activation. Advances in Experimental Medicine and Biology. 691: 89-91. PMID 21153312 DOI: 10.1007/978-1-4419-6612-4_9  0.573
2011 Zheng C, Yin Q, Wu H. Structural studies of NF-κB signaling. Cell Research. 21: 183-95. PMID 21135870 DOI: 10.1038/cr.2010.171  0.566
2010 Wang L, Yang JK, Kabaleeswaran V, Rice AJ, Cruz AC, Park AY, Yin Q, Damko E, Jang SB, Raunser S, Robinson CV, Siegel RM, Walz T, Wu H. The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nature Structural & Molecular Biology. 17: 1324-9. PMID 20935634 DOI: 10.1038/Nsmb.1920  0.619
2009 Yin Q, Lamothe B, Darnay BG, Wu H. Structural basis for the lack of E2 interaction in the RING domain of TRAF2. Biochemistry. 48: 10558-67. PMID 19810754 DOI: 10.1021/bi901462e  0.638
2009 Yin Q, Lin SC, Lamothe B, Lu M, Lo YC, Hura G, Zheng L, Rich RL, Campos AD, Myszka DG, Lenardo MJ, Darnay BG, Wu H. E2 interaction and dimerization in the crystal structure of TRAF6. Nature Structural & Molecular Biology. 16: 658-66. PMID 19465916 DOI: 10.1038/nsmb.1605  0.587
2009 Wang R, Wei Z, Jin H, Wu H, Yu C, Wen W, Chan LN, Wen Z, Zhang M. Autoinhibition of UNC5b revealed by the cytoplasmic domain structure of the receptor. Molecular Cell. 33: 692-703. PMID 19328064 DOI: 10.1016/J.Molcel.2009.02.016  0.307
2009 Pan W, da Graca LS, Shao Y, Yin Q, Wu H, Jiang X. PHAPI/pp32 suppresses tumorigenesis by stimulating apoptosis. The Journal of Biological Chemistry. 284: 6946-54. PMID 19121999 DOI: 10.1074/Jbc.M805801200  0.6
2007 Gao Z, Tian Y, Wang J, Yin Q, Wu H, Li YM, Jiang X. A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP. Dynamic and cooperative regulation of XIAP by Smac/Diablo. The Journal of Biological Chemistry. 282: 30718-27. PMID 17724022 DOI: 10.1074/Jbc.M705258200  0.618
2007 Lin SC, Huang Y, Lo YC, Lu M, Wu H. Crystal structure of the BIR1 domain of XIAP in two crystal forms. Journal of Molecular Biology. 372: 847-54. PMID 17698078 DOI: 10.1016/J.Jmb.2007.07.019  0.656
2007 Chung JY, Lu M, Yin Q, Lin SC, Wu H. Molecular basis for the unique specificity of TRAF6. Advances in Experimental Medicine and Biology. 597: 122-30. PMID 17633022 DOI: 10.1007/978-0-387-70630-6_10  0.57
2007 Chung JY, Lu M, Yin Q, Wu H. Structural revelations of TRAF2 function in TNF receptor signaling pathway. Advances in Experimental Medicine and Biology. 597: 93-113. PMID 17633020 DOI: 10.1007/978-0-387-70630-6_8  0.622
2007 Lu M, Lin SC, Huang Y, Kang YJ, Rich R, Lo YC, Myszka D, Han J, Wu H. XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. Molecular Cell. 26: 689-702. PMID 17560374 DOI: 10.1016/J.Molcel.2007.05.006  0.652
2007 Park HH, Logette E, Raunser S, Cuenin S, Walz T, Tschopp J, Wu H. Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell. 128: 533-46. PMID 17289572 DOI: 10.1016/J.Cell.2007.01.019  0.301
2006 Yin Q, Park HH, Chung JY, Lin SC, Lo YC, da Graca LS, Jiang X, Wu H. Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine. Molecular Cell. 22: 259-68. PMID 16630893 DOI: 10.1016/j.molcel.2006.03.030  0.599
2006 Park HH, Wu H. Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly Journal of Molecular Biology. 357: 358-364. PMID 16434054 DOI: 10.1016/j.jmb.2005.12.082  0.318
2005 Yang JK, Wang L, Zheng L, Wan F, Ahmed M, Lenardo MJ, Wu H. Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition. Molecular Cell. 20: 939-49. PMID 16364918 DOI: 10.1016/j.molcel.2005.10.023  0.314
2004 Wu H. Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily Advances in Protein Chemistry. 68: 225-279. PMID 15500863 DOI: 10.1016/S0065-3233(04)68007-7  0.305
2004 Huang Y, Lu M, Wu H. Antagonizing XIAP-mediated caspase-3 inhibition. Achilles' heel of cancers? Cancer Cell. 5: 1-2. PMID 14749118 DOI: 10.1016/S1535-6108(03)00340-4  0.616
2003 Huang Y, Rich RL, Myszka DG, Wu H. Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac. The Journal of Biological Chemistry. 278: 49517-22. PMID 14512414 DOI: 10.1074/Jbc.M310061200  0.65
2003 Xu G, Rich RL, Steegborn C, Min T, Huang Y, Myszka DG, Wu H. Mutational analyses of the p35-caspase interaction. A bowstring kinetic model of caspase inhibition by p35. The Journal of Biological Chemistry. 278: 5455-61. PMID 12458208 DOI: 10.1074/Jbc.M211607200  0.626
2002 Moldovan MC, Yachou A, Lévesque K, Wu H, Hendrickson WA, Cohen EA, Sékaly RP. CD4 dimers constitute the functional component required for T cell activation Journal of Immunology. 169: 6261-6268. PMID 12444132 DOI: 10.4049/Jimmunol.169.11.6261  0.49
2001 Xu G, Cirilli M, Huang Y, Rich RL, Myszka DG, Wu H. Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex. Nature. 410: 494-7. PMID 11260720 DOI: 10.1038/35068604  0.614
2001 Huang Y, Park YC, Rich RL, Segal D, Myszka DG, Wu H. Structural Basis of Caspase Inhibition by XIAP Cell. 104: 781-790. DOI: 10.1016/S0092-8674(01)00273-2  0.632
1997 Wu H, Kwong PD, Hendrickson WA. Dimeric association and segmental variability in the structure of human CD4. Nature. 387: 527-30. PMID 9168119 DOI: 10.1038/387527A0  0.492
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