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Alexander L Nielsen - Publications

Affiliations: 
University of Copenhagen, København, Denmark 
Area:
Medicinal Chemistry
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14 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Bolding JE, Nielsen AL, Jensen I, Hansen TN, Ryberg LA, Jameson ST, Harris P, Peters GHJ, Denu JM, Rogers JM, Olsen CA. Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide-Activated Sirtuin 7. Angewandte Chemie (International Ed. in English). e202314597. PMID 37873919 DOI: 10.1002/anie.202314597  0.647
2023 Lin L, Patel EN, Nielsen AL, Turner LD, Tepp WH, Nguyen K, Pellett S, Janda K. Transformation of a Metal Chelate into a "Catch and Anchor" Inhibitor of Botulinum A Protease. International Journal of Molecular Sciences. 24. PMID 36901734 DOI: 10.3390/ijms24054303  0.559
2022 Rajabi N, Hansen TN, Nielsen AL, Nguyen HT, Baek M, Bolding JE, Bahlke OØ, Petersen SEG, Bartling CRO, Strømgaard K, Olsen CA. Investigation of Carboxylic Acid Isosteres and Prodrugs for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme. Angewandte Chemie (International Ed. in English). e202115805. PMID 35299278 DOI: 10.1002/anie.202115805  0.698
2022 Moreno-Yruela C, Zhang D, Wei W, Bæk M, Liu W, Gao J, Danková D, Nielsen AL, Bolding JE, Yang L, Jameson ST, Wong J, Olsen CA, Zhao Y. Class I histone deacetylases (HDAC1-3) are histone lysine delactylases. Science Advances. 8: eabi6696. PMID 35044827 DOI: 10.1126/sciadv.abi6696  0.545
2021 Troelsen KS, Bæk M, Nielsen AL, Madsen AS, Rajabi N, Olsen CA. Mitochondria-targeted inhibitors of the human SIRT3 lysine deacetylase. Rsc Chemical Biology. 2: 627-635. PMID 34458804 DOI: 10.1039/d0cb00216j  0.683
2021 Nielsen AL, Rajabi N, Kudo N, Lundø K, Moreno-Yruela C, Bæk M, Fontenas M, Lucidi A, Madsen AS, Yoshida M, Olsen CA. Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration. Rsc Chemical Biology. 2: 612-626. PMID 34458803 DOI: 10.1039/d0cb00036a  0.689
2021 Turner LD, Nielsen AL, Lin L, Campedelli AJ, Silvaggi NR, Chen JS, Wakefield AE, Allen KN, Janda KD. Use of Crystallography and Molecular Modeling for the Inhibition of the Botulinum Neurotoxin A Protease. Acs Medicinal Chemistry Letters. 12: 1318-1324. PMID 34413962 DOI: 10.1021/acsmedchemlett.1c00325  0.595
2021 Turner LD, Nielsen AL, Lin L, Pellett S, Sugane T, Olson ME, Johnson EA, Janda KD. Irreversible inhibition of BoNT/A protease: proximity-driven reactivity contingent upon a bifunctional approach. Rsc Medicinal Chemistry. 12: 960-969. PMID 34223161 DOI: 10.1039/d1md00089f  0.614
2021 Shirey RJ, Hart JR, Sridharan B, Novick SJ, Turner LD, Zhou B, Nielsen AL, Eubanks LM, Ueno L, Hixon MS, Lairson LL, Spicer TP, Scampavia LD, Griffin PR, Vogt PK, et al. Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay. Bioorganic & Medicinal Chemistry. 42: 116246. PMID 34130216 DOI: 10.1016/j.bmc.2021.116246  0.531
2021 Turner LD, Nielsen AL, Lin L, Pellett S, Sugane T, Olson ME, Janda KD. COVALENT INHIBITION OF BOTULINUM NEUROTOXIN A - EXPLORATION OF WARHEAD REACTIVITY AND FUNCTION USING A BIFUNCTIONAL APPROACH. Toxicon : Official Journal of the International Society On Toxinology. 190: S72-S73. PMID 34103769  0.513
2021 Nielsen AL, Rajabi N, Kudo N, Lundø K, Moreno-Yruela C, Bæk M, Fontenas M, Lucidi A, Madsen AS, Yoshida M, Olsen CA. Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration Rsc Chemical Biology. 2: 612-626. DOI: 10.1039/D0CB00036A  0.658
2020 Rajabi N, Nielsen AL, Olsen CA. Dethioacylation by Sirtuins 1-3: Considerations for Drug Design Using Mechanism-Based Sirtuin Inhibition. Acs Medicinal Chemistry Letters. 11: 1886-1892. PMID 33062169 DOI: 10.1021/Acsmedchemlett.9B00580  0.662
2020 Lin L, Olson ME, Sugane T, Turner LD, Tararina MA, Nielsen AL, Kurbanov EK, Pellett S, Johnson EA, Cohen SM, Allen KN, Janda KD. A Catch and Anchor Approach to Combat both Toxicity and Longevity of Botulinum Toxin A. Journal of Medicinal Chemistry. PMID 32886509 DOI: 10.1021/Acs.Jmedchem.0C01006  0.622
2020 Nielsen AL, Olsen CA. Finding the gas pedal on a slow sirtuin. The Journal of Biological Chemistry. 295: 1400-1401. PMID 32005646 DOI: 10.1074/Jbc.H120.012534  0.601
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