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Marek Orzechowski - Publications

Affiliations: 
2010-2015 Broad Institute (MIT/Harvard) 
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26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Farman GP, Rynkiewicz MJ, Orzechowski M, Lehman W, Moore JR. HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments. Archives of Biochemistry and Biophysics. PMID 29626422 DOI: 10.1016/J.Abb.2018.04.002  0.669
2017 Viswanathan MC, Schmidt W, Orzechowski M, Lehman W, Cammarato A. The Actc A295S Hypertrophic Cardiomyopathy Mutation Promotes Thin Filament Disinhibition and Enhances Contractile Activity Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.3013  0.731
2016 Farman GP, Rynkiewicz M, Orzechowski M, Lehman W, Moore J. Cardiomyopathy Linked Mutations in Alpha Tropomyosin Influence Blocked State Stability but not Myosin Strong Binding Biophysical Journal. 110: 124a-125a. DOI: 10.1016/J.Bpj.2015.11.718  0.72
2016 Rynkiewicz M, Schott V, Orzechowski M, Fischer S, Lehman W. Does Tropomyosin Slide or Roll over F-Actin during Regulatory Transitions? Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.2805  0.707
2015 Rynkiewicz MJ, Schott V, Orzechowski M, Lehman W, Fischer S. Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin. Journal of Muscle Research and Cell Motility. 36: 525-33. PMID 26286845 DOI: 10.1007/S10974-015-9419-Z  0.704
2015 Farman GP, Orzechowski M, Fischer S, William L, Moore JR. Serine 61 Phosphorylation Rescues Cardiomyopathic Effects of Tropomyosin Mutation Biophysical Journal. 108: 446a-447a. DOI: 10.1016/J.Bpj.2014.11.2437  0.571
2014 Orzechowski M, Fischer S, Moore JR, Lehman W, Farman GP. Energy landscapes reveal the myopathic effects of tropomyosin mutations. Archives of Biochemistry and Biophysics. 564: 89-99. PMID 25241052 DOI: 10.1016/J.Abb.2014.09.007  0.698
2014 Orzechowski M, Li XE, Fischer S, Lehman W. An atomic model of the tropomyosin cable on F-actin. Biophysical Journal. 107: 694-9. PMID 25099808 DOI: 10.1016/J.Bpj.2014.06.034  0.764
2014 Li XE, Orzechowski M, Lehman W, Fischer S. Structure and flexibility of the tropomyosin overlap junction. Biochemical and Biophysical Research Communications. 446: 304-8. PMID 24607906 DOI: 10.1016/J.Bbrc.2014.02.097  0.742
2014 Yang S, Barbu-Tudoran L, Orzechowski M, Craig R, Trinick J, White H, Lehman W. Three-dimensional organization of troponin on cardiac muscle thin filaments in the relaxed state. Biophysical Journal. 106: 855-64. PMID 24559988 DOI: 10.1016/J.Bpj.2014.01.007  0.692
2014 Orzechowski M, Moore JR, Fischer S, Lehman W. Tropomyosin movement on F-actin during muscle activation explained by energy landscapes Archives of Biochemistry and Biophysics. 545: 63-68. PMID 24412204 DOI: 10.1016/J.Abb.2014.01.001  0.712
2014 Lehman W, Li XE, Orzechowski M, Fischer S. The structural dynamics of α-tropomyosin on F-actin shape the overlap complex between adjacent tropomyosin molecules. Archives of Biochemistry and Biophysics. 552: 68-73. PMID 24071513 DOI: 10.1016/J.Abb.2013.09.011  0.754
2014 Lehman W, Li X, Orzechowski M, Fischer S. The Structural Dynamics of Alpha-Tropomyosin on F-Actin Shape the Overlap Complex between Adjacent Tropomyosin Molecules Biophysical Journal. 106: 7-9. DOI: 10.1016/J.Bpj.2013.11.4223  0.73
2014 Orzechowski M, Fischer S, Moore JR, Lehman W, Farman GP. Energy landscapes reveal the myopathic effects of tropomyosin mutations Archives of Biochemistry and Biophysics. 564: 89-99. DOI: 10.1016/j.abb.2014.09.007  0.49
2013 Lehman W, Orzechowski M, Li XE, Fischer S, Raunser S. Gestalt-binding of tropomyosin on actin during thin filament activation. Journal of Muscle Research and Cell Motility. 34: 155-63. PMID 23666668 DOI: 10.1007/S10974-013-9342-0  0.749
2013 Li X(, Orzechowski M, Fischer S, Lehman W. Tropomyosin Flexibility and Transitions between Thin Filament On- and Off-States Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.2656  0.762
2013 Orzechowski M, Fischer S, Lehman W. Influence of Actin Mutation on the Energy Landscape of Actin-Tropomyosin Filaments Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.2654  0.676
2013 Yang S, Barbu-Tudoran L, Orzechowski M, Craig R, Trinick J, Lehman W, White H. 3D-Reconstruction Reveals the Organization of Troponin on Cardiac Thin Filaments Biophysical Journal. 104: 453a. DOI: 10.1016/J.Bpj.2012.11.2509  0.664
2012 Orzechowski M, Raunser S, Fischer S, Lehman W. Tropomyosin Movement on F-actin Analyzed by Energy Landscape Determination Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.115  0.72
2011 Orzechowski M, Fischer S, Lehman W. Structural Simulations of Troponin-Regulated Tropomyosin Movement on F-Actin Biophysical Journal. 100: 5-6. DOI: 10.1016/J.Bpj.2010.12.3386  0.737
2010 Orzechowski M, Meuwly M. Dynamics of water filaments in disordered environments. The Journal of Physical Chemistry. B. 114: 12203-12. PMID 20812707 DOI: 10.1021/Jp1051003  0.302
2010 Grubisic I, Shokhirev MN, Orzechowski M, Miyashita O, Tama F. Biased coarse-grained molecular dynamics simulation approach for flexible fitting of X-ray structure into cryo electron microscopy maps. Journal of Structural Biology. 169: 95-105. PMID 19800974 DOI: 10.1016/J.Jsb.2009.09.010  0.339
2010 White KH, Orzechowski M, Fourmy D, Visscher K. Simulated and Mechanical Unfolding of the Beet Western Yellow Virus −1 Frameshift Signal Biophysical Journal. 98: 468a. DOI: 10.1016/J.Bpj.2009.12.2547  0.334
2008 Orzechowski M, Tama F. Flexible fitting of high-resolution x-ray structures into cryoelectron microscopy maps using biased molecular dynamics simulations. Biophysical Journal. 95: 5692-705. PMID 18849406 DOI: 10.1529/Biophysj.108.139451  0.338
2005 Orzechowski M, Cieplak P. Application of steered molecular dynamics (SMD) to study DNA–drug complexes and probing helical propensity of amino acids Journal of Physics: Condensed Matter. 17. DOI: 10.1088/0953-8984/17/18/018  0.318
2002 Orzechowski M, Cieplak P, Piela L. Theoretical calculation of the coiled-coil stability in water in the context of its possible use as a molecular rack. Journal of Computational Chemistry. 23: 106-10. PMID 11913375 DOI: 10.1002/Jcc.10020  0.38
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