Year |
Citation |
Score |
2023 |
Lee S, Ali AR, Abed DA, Nguyen MU, Verzi MP, Hu L. Structural modification of C2-substituents on 1,4-bis(arylsulfonamido)benzene or naphthalene-N,N'-diacetic acid derivatives as potent inhibitors of the Keap1-Nrf2 protein-protein interaction. European Journal of Medicinal Chemistry. 265: 116104. PMID 38159482 DOI: 10.1016/j.ejmech.2023.116104 |
0.704 |
|
2023 |
Abed DA, Ali AR, Lee S, Nguyen MU, Verzi MP, Hu L. Optimization of the C2 substituents on the 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction. European Journal of Medicinal Chemistry. 252: 115302. PMID 36989811 DOI: 10.1016/j.ejmech.2023.115302 |
0.625 |
|
2022 |
Lee S, Abed DA, Nguyen MU, Verzi MP, Hu L. Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N'-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction. European Journal of Medicinal Chemistry. 237: 114380. PMID 35462166 DOI: 10.1016/j.ejmech.2022.114380 |
0.718 |
|
2021 |
Abed DA, Lee S, Wen X, Ali AR, Mangipudy V, Aleksunes LM, Hu L. Optimization of 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acids as inhibitors of Keap1-Nrf2 protein-protein interaction to suppress neuroinflammation. Bioorganic & Medicinal Chemistry. 44: 116300. PMID 34252790 DOI: 10.1016/j.bmc.2021.116300 |
0.678 |
|
2020 |
Lee S, Abed DA, Beamer LJ, Hu L. Development of a Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for the Inhibition of Keap1-Nrf2 Protein-Protein Interaction. Slas Discovery : Advancing Life Sciences R & D. 2472555220935816. PMID 32564647 DOI: 10.1177/2472555220935816 |
0.704 |
|
2020 |
Abed DA, Lee S, Hu L. Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction. Bioorganic & Medicinal Chemistry. 115343. PMID 32046917 DOI: 10.1016/J.Bmc.2020.115343 |
0.686 |
|
2015 |
Abed DA, Goldstein M, Albanyan H, Jin H, Hu L. Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents. Acta Pharmaceutica Sinica. B. 5: 285-299. PMID 26579458 DOI: 10.1016/J.Apsb.2015.05.008 |
0.373 |
|
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