| Year |
Citation |
Score |
| 2023 |
Hancox JC, Copeland CS, Harmer SC, Henderson G. New synthetic cannabinoids and the potential for cardiac arrhythmia risk. Journal of Molecular and Cellular Cardiology Plus. 6: 100049. PMID 38143960 DOI: 10.1016/j.jmccpl.2023.100049 |
0.307 |
|
| 2023 |
Helliwell MV, Zhang Y, El Harchi A, Dempsey CE, Hancox JC. Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue. Pharmaceuticals (Basel, Switzerland). 16. PMID 37765012 DOI: 10.3390/ph16091204 |
0.378 |
|
| 2023 |
El Harchi A, Hancox JC. hERG agonists pose challenges to web-based machine learning methods for prediction of drug-hERG channel interaction. Journal of Pharmacological and Toxicological Methods. 123: 107293. PMID 37468081 DOI: 10.1016/j.vascn.2023.107293 |
0.366 |
|
| 2022 |
Butler AS, Hancox JC, Marrion NV. Preferential formation of human heteromeric SK2:SK3 channels limits homomeric SK channel assembly and function. The Journal of Biological Chemistry. 299: 102783. PMID 36502918 DOI: 10.1016/j.jbc.2022.102783 |
0.445 |
|
| 2022 |
Zhang Y, Grimwood AL, Hancox JC, Harmer SC, Dempsey CE. Evolutionary coupling analysis guides identification of mistrafficking-sensitive variants in cardiac K channels: Validation with hERG. Frontiers in Pharmacology. 13: 1010119. PMID 36339618 DOI: 10.3389/fphar.2022.1010119 |
0.356 |
|
| 2021 |
Al-Moubarak E, Shiels HA, Zhang Y, Du C, Hanington O, Harmer SC, Dempsey CE, Hancox JC. Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant. Cellular and Molecular Life Sciences : Cmls. PMID 34727194 DOI: 10.1007/s00018-021-03967-8 |
0.478 |
|
| 2021 |
Al-Moubarak E, Sharifi M, Hancox JC. Exploration of Interactions Between Potential COVID-19 Antiviral Treatments and the Pore of the hERG Potassium Channel-A Drug Antitarget. Frontiers in Cardiovascular Medicine. 8: 645172. PMID 34017865 DOI: 10.3389/fcvm.2021.645172 |
0.448 |
|
| 2020 |
Zhang Y, Dempsey CE, Hancox JC. Electrophysiological characterization of the modified hERG potassium channel used to obtain the first cryo-EM hERG structure. Physiological Reports. 8: e14568. PMID 33091232 DOI: 10.14814/phy2.14568 |
0.49 |
|
| 2020 |
Caves RE, Carpenter A, Choisy SC, Clennell B, Cheng H, McNiff C, Mann B, Milnes JT, Hancox JC, James AF. Inhibition of voltage-gated Na currents by eleclazine in rat atrial and ventricular myocytes. Heart Rhythm O2. 1: 206-214. PMID 32864638 DOI: 10.1016/j.hroo.2020.05.006 |
0.337 |
|
| 2020 |
Carpenter A, Chambers OJ, El Harchi A, Bond R, Hanington O, Harmer SC, Hancox JC, James AF. COVID-19 Management and Arrhythmia: Risks and Challenges for Clinicians Treating Patients Affected by SARS-CoV-2. Frontiers in Cardiovascular Medicine. 7: 85. PMID 32432127 DOI: 10.3389/fcvm.2020.00085 |
0.309 |
|
| 2020 |
Al-Moubarak E, Zhang Y, Dempsey CE, Zhang H, Harmer SC, Hancox JC. Serine mutation of a conserved threonine in the hERG K channel S6-pore region leads to loss-of-function through trafficking impairment. Biochemical and Biophysical Research Communications. PMID 32321643 DOI: 10.1016/J.Bbrc.2020.04.003 |
0.349 |
|
| 2020 |
El Harchi A, Butler AS, Zhang Y, Dempsey CE, Hancox JC. The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine. Physiological Reports. 8: e14385. PMID 32147975 DOI: 10.14814/Phy2.14385 |
0.387 |
|
| 2020 |
Al-Moubarak E, Shiels H, Zhang Y, Du C, Dempsey C, Hancox J. Inhibition of hERG Potassium Channels by the Polycylic Aromatic Hydrocarbon Phenanthrene Biophysical Journal. 118: 109a. DOI: 10.1016/J.Bpj.2019.11.744 |
0.561 |
|
| 2019 |
Butler A, Helliwell MV, Zhang Y, Hancox JC, Dempsey CE. An Update on the Structure of hERG. Frontiers in Pharmacology. 10: 1572. PMID 32038248 DOI: 10.3389/Fphar.2019.01572 |
0.392 |
|
| 2019 |
Wilson SL, Dempsey CE, Hancox JC, Marrion NV. Identification of a proton sensor that regulates conductance and open time of single hERG channels. Scientific Reports. 9: 19825. PMID 31882846 DOI: 10.1038/S41598-019-56081-Y |
0.644 |
|
| 2019 |
Lei CL, Clerx M, Beattie KA, Melgari D, Hancox JC, Gavaghan DJ, Polonchuk L, Wang K, Mirams GR. Rapid Characterization of hERG Channel Kinetics II: Temperature Dependence. Biophysical Journal. PMID 31451180 DOI: 10.1016/J.Bpj.2019.07.030 |
0.716 |
|
| 2019 |
Cheng H, Du C, Zhang Y, James AF, Dempsey CE, Abdala AP, Hancox JC. Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome. Journal of Molecular and Cellular Cardiology. PMID 31362019 DOI: 10.1016/J.Yjmcc.2019.07.012 |
0.455 |
|
| 2019 |
Butler A, Zhang Y, Stuart AG, Dempsey CE, Hancox JC. Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome. Heliyon. 5: e01429. PMID 31049424 DOI: 10.1016/J.Heliyon.2019.E01429 |
0.406 |
|
| 2019 |
Shamsaldeen YA, Culliford L, Clout M, James AF, Ascione R, Hancox JC, Marrion NV. Role of SK channel activation in determining the action potential configuration in freshly isolated human atrial myocytes from the SKArF study. Biochemical and Biophysical Research Communications. PMID 30922569 DOI: 10.1016/j.bbrc.2019.03.074 |
0.474 |
|
| 2018 |
Butler A, Zhang Y, Stuart AG, Dempsey CE, Hancox JC. Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome. Physiological Reports. 6: e13845. PMID 30175559 DOI: 10.14814/Phy2.13845 |
0.336 |
|
| 2018 |
Helliwell MV, Zhang Y, El Harchi A, Du C, Hancox JC, Dempsey CE.
. The Journal of Biological Chemistry. PMID 29545312 DOI: 10.1074/Jbc.Ra117.000363 |
0.437 |
|
| 2018 |
Lainez S, Doray A, Hancox JC, Cannell MB. Regulation of Kv4.3 and hERG potassium channels by KChIP2 isoforms and DPP6 and response to the dual K+ channel activator NS3623. Biochemical Pharmacology. 150: 120-130. PMID 29378180 DOI: 10.1016/j.bcp.2018.01.036 |
0.465 |
|
| 2018 |
Hancox J, El Harchi A, Melgari D, Zhang H. Investigation of hERG1b influence on hERG channel pharmacology at physiological temperature Journal of Pharmacology and Pharmacotherapeutics. 9: 92. DOI: 10.4103/Jpp.Jpp_158_17 |
0.745 |
|
| 2018 |
Hancox JC, Zhang Y, Colenso CK, Dempsey CE. An exploration of interactions between the antiarrhythmic drug dronedarone and hERG potassium channel pore Journal of Integrative Cardiology Open Access. 1. DOI: 10.31487/j.JICOA.2018.01.002 |
0.396 |
|
| 2017 |
Whittaker DG, Ni H, Benson AP, Hancox JC, Zhang H. Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles. Frontiers in Physiology. 8: 759. PMID 29085299 DOI: 10.3389/Fphys.2017.00759 |
0.41 |
|
| 2017 |
Zhang YH, Dempsey CE, Hancox JC. The Basis for Low-affinity hERG Potassium Channel Block by Sotalol. Journal of Pharmacology & Pharmacotherapeutics. 8: 130-131. PMID 29081622 DOI: 10.4103/Jpp.Jpp_69_17 |
0.462 |
|
| 2017 |
Mitcheson JS, Hancox JC. Modulation of hERG potassium channels by a novel small molecule activator. British Journal of Pharmacology. PMID 28887817 DOI: 10.1111/bph.13964 |
0.378 |
|
| 2017 |
Caves RE, Cheng H, Choisy SC, Gadeberg HC, Bryant SM, Hancox JC, James AF. Atrial-ventricular differences in rabbit cardiac voltage-gated Na(+) currents: basis for atrial-selective block by ranolazine. Heart Rhythm. PMID 28610990 DOI: 10.1016/j.hrthm.2017.06.012 |
0.323 |
|
| 2017 |
Cheng H, Cannell MB, Hancox JC. Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Ito modulator NS5806. Physiological Reports. 5. PMID 28270595 DOI: 10.14814/phy2.13172 |
0.309 |
|
| 2017 |
Zhang Y, Marrion N, Harmer S, Mohamed R, Tinker A, Hancox J. 227hERG potassium channel modulation by P127T KCNE1 Ep Europace. 19: iii22-iii22. DOI: 10.1093/Ehjci/Eux138.002 |
0.478 |
|
| 2017 |
Helliwell MV, Hancox JC, Zhang YH, Dempsey CE. The Roles of Selected Pore Residues in Pharmacological Inhibition of the hERG Potassium Channel by a Minimally Structured Blocker Biophysical Journal. 112: 410a-411a. DOI: 10.1016/J.Bpj.2016.11.2558 |
0.41 |
|
| 2017 |
Wilson SL, Marrion NV, Hancox JC. The Effects of Extracellular Protons on the hERG Potassium Channel Biophysical Journal. 112: 410a. DOI: 10.1016/J.BPJ.2016.11.2557 |
0.448 |
|
| 2016 |
Melgari D, Ng GA, Hancox JC. Letter by Melgari et al Regarding Article, "Ivabradine: Role in the Chronic Heart Failure Armamentarium". Circulation. 134: e296-7. PMID 27672201 DOI: 10.1161/Circulationaha.116.023752 |
0.66 |
|
| 2016 |
Hancox JC. Considering Ranolazine as a Potential Treatment for K+ Channel Linked Short QT Syndrome. Journal of Cardiovascular Electrophysiology. PMID 27477827 DOI: 10.1111/jce.13055 |
0.34 |
|
| 2016 |
Cheng H, Curtis AE, Fellingham C, Hancox JC. Multiple ion channel block by the cation channel inhibitor SKF-96365 in myocytes from the rabbit atrioventricular node. Physiological Reports. 4. PMID 27288059 DOI: 10.14814/phy2.12819 |
0.337 |
|
| 2016 |
Zhang Y, Colenso CK, Harchi AE, Cheng H, Witchel HJ, Dempsey CE, Hancox JC. Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking. Biochemical Pharmacology. PMID 27256139 DOI: 10.1016/J.Bcp.2016.05.013 |
0.446 |
|
| 2016 |
Hancox JC, James AF, Marrion NV, Zhang H, Thomas D. Novel ion channel targets in atrial fibrillation. Expert Opinion On Therapeutic Targets. PMID 26918581 DOI: 10.1517/14728222.2016.1159300 |
0.41 |
|
| 2016 |
Beattie K, Melgari D, Hancox J, Mirams G. Exploring temperature-dependence of hERG channel kinetics using sine wave voltage protocols Journal of Pharmacological and Toxicological Methods. 81: 339-340. DOI: 10.1016/J.Vascn.2016.02.017 |
0.746 |
|
| 2015 |
Hancox JC, Melgari D, Dempsey CE, Brack KE, Mitcheson J, Ng GA. hERG potassium channel inhibition by ivabradine may contribute to QT prolongation and risk of torsades de pointes. Therapeutic Advances in Drug Safety. 6: 177-9. PMID 26301071 DOI: 10.1177/2042098615595546 |
0.722 |
|
| 2015 |
Melgari D, Brack KE, Zhang Y, El Harchi A, Mitcheson JS, Dempsey CE, Ng GA, Hancox JC. hERG potassium channel inhibition by ivabradine requires channel gating. Journal of Molecular and Cellular Cardiology. 87: 126-8. PMID 26275355 DOI: 10.1016/J.Yjmcc.2015.08.002 |
0.774 |
|
| 2015 |
Fermini B, Hancox JC, Abi-Gerges N, Bridgland-Taylor M, Chaudhary KW, Colatsky T, Correll K, Crumb W, Damiano B, Erdemli G, Gintant G, Imredy J, Koerner J, Kramer J, Levesque P, et al. A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm. Journal of Biomolecular Screening. PMID 26170255 DOI: 10.1177/1087057115594589 |
0.312 |
|
| 2015 |
Melgari D, Zhang Y, El Harchi A, Dempsey CE, Hancox JC. Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide. Journal of Molecular and Cellular Cardiology. PMID 26159617 DOI: 10.1016/J.Yjmcc.2015.06.021 |
0.76 |
|
| 2015 |
Melgari D, Brack KE, Zhang C, Zhang Y, El Harchi A, Mitcheson JS, Dempsey CE, Ng GA, Hancox JC. hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine. Journal of the American Heart Association. 4. PMID 25911606 DOI: 10.1161/Jaha.115.001813 |
0.78 |
|
| 2015 |
Hancock JM, Weatherall KL, Choisy SC, James AF, Hancox JC, Marrion NV. Selective activation of heteromeric SK channels contributes to action potential repolarization in mouse atrial myocytes. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 12: 1003-15. PMID 25620048 DOI: 10.1016/j.hrthm.2015.01.027 |
0.436 |
|
| 2015 |
Hancox JC, Melgari D, Dempsey CE, Brack KE, Mitcheson J, Ng GA. hERG potassium channel inhibition by ivabradine may contribute to QT prolongation and risk of torsades de pointes Therapeutic Advances in Drug Safety. 6: 177-179. DOI: 10.1177/2042098615595546 |
0.758 |
|
| 2015 |
Melgari D, Brack KE, Zhang Y, El Harchi A, Mitcheson JS, Dempsey CE, Ng GA, Hancox JC. HERG potassium channel inhibition by ivabradine requires channel gating Journal of Molecular and Cellular Cardiology. 87: 126-128. DOI: 10.1016/j.yjmcc.2015.08.002 |
0.774 |
|
| 2014 |
Melgari D, Du C, El Harchi A, Zhang Y, Hancox JC. Suppression of the hERG potassium channel response to premature stimulation by reduction in extracellular potassium concentration. Physiological Reports. 2. PMID 25318749 DOI: 10.14814/Phy2.12165 |
0.732 |
|
| 2014 |
Bond RC, Choisy SC, Bryant SM, Hancox JC, James AF. Inhibition of a TREK-like K+ channel current by noradrenaline requires both β1- and β2-adrenoceptors in rat atrial myocytes. Cardiovascular Research. 104: 206-15. PMID 25205295 DOI: 10.1093/cvr/cvu192 |
0.338 |
|
| 2014 |
Alexandrou AJ, Milnes JT, Sun SZ, Fermini B, Kim SC, Jenkinson S, Leishman DJ, Witchel HJ, Hancox JC, Leaney JL. The human ether-a'-go-go related gene (hERG) K+ channel blockade by the investigative selective-serotonin reuptake inhibitor CONA-437: Limited dependence on s6 aromatic residues Journal of Physiology and Pharmacology. 65: 511-523. PMID 25179083 |
0.528 |
|
| 2014 |
Hancox JC, Du C, Harchi AE, Zhang H. Modification of KCNH2-encoded cardiac potassium channels by KCNE1 polymorphism Circulation Journal. 78: 2330. PMID 25008780 DOI: 10.1253/circj.CJ-14-0513 |
0.388 |
|
| 2014 |
Du C, Zhang Y, El Harchi A, Dempsey CE, Hancox JC. Ranolazine inhibition of hERG potassium channels: drug-pore interactions and reduced potency against inactivation mutants. Journal of Molecular and Cellular Cardiology. 74: 220-30. PMID 24877995 DOI: 10.1016/J.Yjmcc.2014.05.013 |
0.419 |
|
| 2014 |
Zhang YH, EI Harchi A, Dempsey CE, Hancox JC. Inverstigating Stereoselectivity of Pharmacological Inhibition of Herg Channels Biophysical Journal. 106: 139a. DOI: 10.1016/J.Bpj.2013.11.809 |
0.326 |
|
| 2014 |
Melgari D, El Harchi A, Dempsey CE, Hancox JC. Sensitivity of Flecainide Inhibition of hERG Channels to Channel Inactivation Biophysical Journal. 106: 138a. DOI: 10.1016/J.Bpj.2013.11.807 |
0.746 |
|
| 2014 |
Bond RC, Choisy SC, Bryant SM, Hancox JC, James AF. A Trek-Like K+ Channel Current Inhibited by Norepinephrine in Rat Atrial Myocytes Biophysical Journal. 106: 120a. DOI: 10.1016/J.BPJ.2013.11.719 |
0.401 |
|
| 2013 |
Du C, El Harchi A, Zhang H, Hancox JC. Modification by KCNE1 variants of the hERG potassium channel response to premature stimulation and to pharmacological inhibition. Physiological Reports. 1: e00175. PMID 24400172 DOI: 10.1002/Phy2.175 |
0.489 |
|
| 2013 |
Colenso CK, Sessions RB, Zhang YH, Hancox JC, Dempsey CE. Interactions between voltage sensor and pore domains in a hERG K+ channel model from molecular simulations and the effects of a voltage sensor mutation. Journal of Chemical Information and Modeling. 53: 1358-70. PMID 23672495 DOI: 10.1021/Ci4000739 |
0.302 |
|
| 2013 |
El Harchi A, Melgari D, Hancox JC. Investigation of the Influence of hERG 1b on hERG Channel Pharmacology Biophysical Journal. 104: 297a. DOI: 10.1016/J.Bpj.2012.11.1655 |
0.739 |
|
| 2013 |
Hancock J, James AF, Hancox JC, Marrion NV. Effects of SK Channel Blockers on Atrial Myocytes Suggest SK Channel Heterogeneity Biophysical Journal. 104: 283a. DOI: 10.1016/J.BPJ.2012.11.1585 |
0.481 |
|
| 2012 |
El Harchi A, Melgari D, Zhang YH, Zhang H, Hancox JC. Action Potential Clamp and Pharmacology of the Variant 1 Short QT Syndrome T618I hERG K+ Channel Plos One. 7. PMID 23300672 DOI: 10.1371/Journal.Pone.0052451 |
0.751 |
|
| 2012 |
El Harchi A, Zhang YH, Hussein L, Dempsey CE, Hancox JC. Molecular determinants of hERG potassium channel inhibition by disopyramide. Journal of Molecular and Cellular Cardiology. 52: 185-95. PMID 21989164 DOI: 10.1016/J.Bpj.2010.12.2534 |
0.399 |
|
| 2012 |
Cheng H, Zhang Y, Du C, Dempsey CE, Hancox JC. High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943. British Journal of Pharmacology. 165: 2260-73. PMID 21950687 DOI: 10.1111/J.1476-5381.2011.01688.X |
0.39 |
|
| 2011 |
Hancox JC. Cardiac ion channel modulation by the hypoglycaemic agent rosiglitazone. British Journal of Pharmacology. 163: 496-8. PMID 21561443 DOI: 10.1111/j.1476-5381.2011.01281.x |
0.358 |
|
| 2011 |
Ohno S, Zankov DP, Ding WG, Itoh H, Makiyama T, Doi T, Shizuta S, Hattori T, Miyamoto A, Naiki N, Hancox JC, Matsuura H, Horie M. KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation. Circulation. Arrhythmia and Electrophysiology. 4: 352-61. PMID 21493962 DOI: 10.1161/CIRCEP.110.959619 |
0.327 |
|
| 2011 |
Du CY, El Harchi A, Zhang YH, Orchard CH, Hancox JC. Pharmacological inhibition of the hERG potassium channel is modulated by extracellular but not intracellular acidosis Journal of Cardiovascular Electrophysiology. 22: 1163-1170. PMID 21489024 DOI: 10.1111/J.1540-8167.2011.02060.X |
0.492 |
|
| 2011 |
Barman PP, Choisy SC, Gadeberg HC, Hancox JC, James AF. Cardiac ion channel current modulation by the CFTR inhibitor GlyH-101. Biochemical and Biophysical Research Communications. 408: 12-7. PMID 21439936 DOI: 10.1016/j.bbrc.2011.03.089 |
0.401 |
|
| 2011 |
Du CY, El Harchi A, McPate MJ, Orchard CH, Hancox JC. Enhanced inhibitory effect of acidosis on hERG potassium channels that incorporate the hERG1b isoform Biochemical and Biophysical Research Communications. 405: 222-227. PMID 21219869 DOI: 10.1016/J.Bbrc.2011.01.014 |
0.462 |
|
| 2011 |
Hancock JM, James AF, Hancox JC, Marrion NV. Evidence for Functional SK Channels in Isolated Atrial Myocytes Biophysical Journal. 100: 572a-573a. DOI: 10.1016/J.BPJ.2010.12.3314 |
0.392 |
|
| 2010 |
El Harchi A, Zhang H, Hancox JC. The S140G KCNQ1 atrial fibrillation mutation affects 'I(KS)' profile during both atrial and ventricular action potentials. Journal of Physiology and Pharmacology : An Official Journal of the Polish Physiological Society. 61: 759-64. PMID 21224508 |
0.316 |
|
| 2010 |
Zhang YH, Cheng H, Alexeenko VA, Dempsey CE, Hancox JC. Characterization of recombinant hERG K(+) channel inhibition by the active metabolite of amiodarone desethyl-amiodarone. Journal of Electrocardiology. 43: 440-8. PMID 20493497 DOI: 10.1016/J.Jelectrocard.2010.04.007 |
0.525 |
|
| 2010 |
Du CY, Adeniran I, Cheng H, Zhang YH, El Harchi A, McPate MJ, Zhang H, Orchard CH, Hancox JC. Acidosis Impairs the Protective Role of hERG K+ Channels Against Premature Stimulation Journal of Cardiovascular Electrophysiology. 21: 1160-1169. PMID 20455975 DOI: 10.1111/J.1540-8167.2010.01772.X |
0.347 |
|
| 2010 |
El Harchi A, McPate MJ, Zhang YH, Zhang H, Hancox JC. Action potential clamp and mefloquine sensitivity of recombinant 'I KS' channels incorporating the V307L KCNQ1 mutation. Journal of Physiology and Pharmacology : An Official Journal of the Polish Physiological Society. 61: 123-31. PMID 20436212 |
0.449 |
|
| 2010 |
Milnes JT, Witchel HJ, Leaney JL, Leishman DJ, Hancox JC. Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide. Journal of Pharmacological and Toxicological Methods. 61: 178-91. PMID 20172036 DOI: 10.1016/j.vascn.2010.02.007 |
0.447 |
|
| 2010 |
Adeniran I, Hancox J, Zhang H. Development of a biophysically detailed model of the rapid-delayed rectifier potassium channel Computing in Cardiology. 37: 637-640. |
0.414 |
|
| 2009 |
McPate MJ, Zhang H, Cordeiro JM, Dempsey CE, Witchel HJ, Hancox JC. hERG1a/1b heteromeric currents exhibit amplified attenuation of inactivation in variant 1 short QT syndrome. Biochemical and Biophysical Research Communications. 386: 111-7. PMID 19501051 DOI: 10.1016/J.Bbrc.2009.05.134 |
0.387 |
|
| 2009 |
McPate MJ, Zhang H, Adeniran I, Cordeiro JM, Witchel HJ, Hancox JC. Comparative effects of the short QT N588K mutation at 37 degrees C on hERG K+ channel current during ventricular, Purkinje fibre and atrial action potentials: an action potential clamp study. Journal of Physiology and Pharmacology : An Official Journal of the Polish Physiological Society. 60: 23-41. PMID 19439805 |
0.327 |
|
| 2009 |
El Harchi A, McPate MJ, Zhang Yh, Zhang H, Hancox JC. Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome. Journal of Molecular and Cellular Cardiology. 47: 743-7. PMID 19285083 DOI: 10.1016/J.Yjmcc.2009.02.027 |
0.467 |
|
| 2008 |
Ridley JM, Shuba YM, James AF, Hancox JC. Modulation by testosterone of an endogenous hERG potassium channel current. Journal of Physiology and Pharmacology : An Official Journal of the Polish Physiological Society. 59: 395-407. PMID 18953086 |
0.442 |
|
| 2008 |
McPate MJ, Duncan RS, Hancox JC, Witchel HJ. Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs. British Journal of Pharmacology. 155: 957-66. PMID 18724381 DOI: 10.1038/bjp.2008.325 |
0.477 |
|
| 2008 |
Hancox JC, McPate MJ, El Harchi A, Zhang YH. The hERG potassium channel and hERG screening for drug-induced torsades de pointes. Pharmacology & Therapeutics. 119: 118-32. PMID 18616963 DOI: 10.1016/j.pharmthera.2008.05.009 |
0.359 |
|
| 2008 |
Hancox JC, James AF. Refining insights into high-affinity drug binding to the human ether-à-go-go-related gene potassium channel. Molecular Pharmacology. 73: 1592-5. PMID 18381562 DOI: 10.1124/mol.108.047563 |
0.448 |
|
| 2008 |
Zhang H, Kharche S, Hancox JC. Mechanistic insights to pro-arrhythmogenesis of short qt syndrome associated with V307L gene mutation in potassium channel (IKs) Wmsci 2008 - the 12th World Multi-Conference On Systemics, Cybernetics and Informatics, Jointly With the 14th International Conference On Information Systems Analysis and Synthesis, Isas 2008 - Proc.. 2: 149-150. |
0.32 |
|
| 2007 |
Li H, Zhang H, Hancox JC, Kozlowski RZ. An outwardly rectifying anionic background current in atrial myocytes from the human heart Biochemical and Biophysical Research Communications. 359: 765-770. PMID 17560943 DOI: 10.1016/J.Bbrc.2007.05.177 |
0.346 |
|
| 2007 |
Duncan RS, McPate MJ, Ridley JM, Gao Z, James AF, Leishman DJ, Leaney JL, Witchel HJ, Hancox JC. Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin. Biochemical Pharmacology. 74: 425-37. PMID 17560554 DOI: 10.1016/j.bcp.2007.04.024 |
0.527 |
|
| 2007 |
Kerr NC, Gao Z, Holmes FE, Hobson SA, Hancox JC, Wynick D, James AF. The sodium channel Nav1.5a is the predominant isoform expressed in adult mouse dorsal root ganglia and exhibits distinct inactivation properties from the full-length Nav1.5 channel. Molecular and Cellular Neurosciences. 35: 283-91. PMID 17433712 DOI: 10.1016/J.Mcn.2007.03.002 |
0.349 |
|
| 2006 |
Milnes JT, Witchel HJ, Leaney JL, Leishman DJ, Hancox JC. hERG K+ channel blockade by the antipsychotic drug thioridazine: An obligatory role for the S6 helix residue F656. Biochemical and Biophysical Research Communications. 351: 273-80. PMID 17056009 DOI: 10.1016/j.bbrc.2006.10.039 |
0.534 |
|
| 2006 |
Hancox JC, Mitcheson JS. Combined hERG channel inhibition and disruption of trafficking in drug-induced long QT syndrome by fluoxetine: a case-study in cardiac safety pharmacology. British Journal of Pharmacology. 149: 457-9. PMID 16967047 DOI: 10.1038/sj.bjp.0706890 |
0.462 |
|
| 2006 |
McPate MJ, Duncan RS, Witchel HJ, Hancox JC. Disopyramide is an effective inhibitor of mutant HERG K+ channels involved in variant 1 short QT syndrome. Journal of Molecular and Cellular Cardiology. 41: 563-6. PMID 16842817 DOI: 10.1016/j.yjmcc.2006.05.021 |
0.368 |
|
| 2006 |
Cheng HW, James AF, Foster RR, Hancox JC, Bates DO. VEGF activates receptor-operated cation channels in human microvascular endothelial cells Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 1768-1776. PMID 16763162 DOI: 10.1161/01.Atv.0000231518.86795.0F |
0.305 |
|
| 2006 |
Ridley JM, Milnes JT, Duncan RS, McPate MJ, James AF, Witchel HJ, Hancox JC. Inhibition of the HERG K+ channel by the antifungal drug ketoconazole depends on channel gating and involves the S6 residue F656. Febs Letters. 580: 1999-2005. PMID 16542653 DOI: 10.1016/j.febslet.2006.02.073 |
0.531 |
|
| 2006 |
Alexandrou AJ, Duncan RS, Sullivan A, Hancox JC, Leishman DJ, Witchel HJ, Leaney JL. Mechanism of hERG K+ channel blockade by the fluoroquinolone antibiotic moxifloxacin. British Journal of Pharmacology. 147: 905-16. PMID 16474415 DOI: 10.1038/sj.bjp.0706678 |
0.512 |
|
| 2006 |
Duncan RS, Ridley JM, Dempsey CE, Leishman DJ, Leaney JL, Hancox JC, Witchel HJ. Erythromycin block of the HERG K+ channel: accessibility to F656 and Y652. Biochemical and Biophysical Research Communications. 341: 500-6. PMID 16446155 DOI: 10.1016/J.Bbrc.2006.01.008 |
0.464 |
|
| 2006 |
Ridley JM, Milnes JT, Hancox JC, Witchel HJ. Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel. Journal of Molecular and Cellular Cardiology. 40: 107-18. PMID 16288909 DOI: 10.1016/j.yjmcc.2005.09.017 |
0.519 |
|
| 2005 |
Gao Z, Milnes JT, Choisy SC, Leach MJ, Hancox JC, James AF. The neuroprotective agent sipatrigine blocks multiple cardiac ion channels and causes triangulation of the ventricular action potential. Clinical and Experimental Pharmacology & Physiology. 32: 1088-96. PMID 16445575 DOI: 10.1111/j.1440-1681.2005.04312.x |
0.301 |
|
| 2005 |
Mitcheson J, Perry M, Stansfeld P, Sanguinetti MC, Witchel H, Hancox J. Structural determinants for high-affinity block of hERG potassium channels. Novartis Foundation Symposium. 266: 136-50; discussion 1. PMID 16050266 DOI: 10.1002/047002142X.Ch11 |
0.563 |
|
| 2005 |
McPate MJ, Duncan RS, Milnes JT, Witchel HJ, Hancox JC. The N588K-HERG K+ channel mutation in the 'short QT syndrome': mechanism of gain-in-function determined at 37 degrees C. Biochemical and Biophysical Research Communications. 334: 441-9. PMID 16011830 DOI: 10.1016/j.bbrc.2005.06.112 |
0.403 |
|
| 2005 |
Doggrell SA, Hancox JC. Ibutilide--recent molecular insights and accumulating evidence for use in atrial flutter and fibrillation. Expert Opinion On Investigational Drugs. 14: 655-69. PMID 15926871 DOI: 10.1517/13543784.14.5.655 |
0.394 |
|
| 2004 |
Ridley JM, Milnes JT, Witchel HJ, Hancox JC. High affinity HERG K(+) channel blockade by the antiarrhythmic agent dronedarone: resistance to mutations of the S6 residues Y652 and F656. Biochemical and Biophysical Research Communications. 325: 883-91. PMID 15541373 DOI: 10.1016/j.bbrc.2004.10.127 |
0.475 |
|
| 2004 |
Choisy SC, Hancox JC, Arberry LA, Reynolds AM, Shattock MJ, James AF. Evidence for a novel K(+) channel modulated by alpha(1A)-adrenoceptors in cardiac myocytes. Molecular Pharmacology. 66: 735-48. PMID 15322267 DOI: 10.1124/mol.104.000760 |
0.368 |
|
| 2004 |
Witchel HJ, Dempsey CE, Sessions RB, Perry M, Milnes JT, Hancox JC, Mitcheson JS. The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping. Molecular Pharmacology. 66: 1201-12. PMID 15308760 DOI: 10.1124/Mol.104.001743 |
0.444 |
|
| 2004 |
Ridley JM, Dooley PC, Milnes JT, Witchel HJ, Hancox JC. Lidoflazine is a high affinity blocker of the HERG K(+)channel. Journal of Molecular and Cellular Cardiology. 36: 701-5. PMID 15135665 DOI: 10.1016/j.yjmcc.2004.02.009 |
0.528 |
|
| 2004 |
Yuill KH, Borg JJ, Ridley JM, Milnes JT, Witchel HJ, Paul AA, Kozlowski RZ, Hancox JC. Potent inhibition of human cardiac potassium (HERG) channels by the anti-estrogen agent clomiphene-without QT interval prolongation. Biochemical and Biophysical Research Communications. 318: 556-61. PMID 15120636 DOI: 10.1016/j.bbrc.2004.04.063 |
0.428 |
|
| 2004 |
Milnes JT, Crociani O, Arcangeli A, Hancox JC, Witchel HJ. Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652. British Journal of Pharmacology. 139: 887-98. PMID 12839862 DOI: 10.1038/sj.bjp.0705335 |
0.496 |
|
| 2003 |
Witchel HJ, Milnes JT, Mitcheson JS, Hancox JC. Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes. Journal of Pharmacological and Toxicological Methods. 48: 65-80. PMID 14565563 DOI: 10.1016/S1056-8719(03)00041-8 |
0.449 |
|
| 2003 |
Milnes JT, Dempsey CE, Ridley JM, Crociani O, Arcangeli A, Hancox JC, Witchel HJ. Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin. Febs Letters. 547: 20-6. PMID 12860380 DOI: 10.1016/S0014-5793(03)00662-8 |
0.452 |
|
| 2003 |
Ridley JM, Milnes JT, Benest AV, Masters JD, Witchel HJ, Hancox JC. Characterisation of recombinant HERG K+ channel blockade by the Class Ia antiarrhythmic drug procainamide. Biochemical and Biophysical Research Communications. 306: 388-93. PMID 12804575 DOI: 10.1016/S0006-291X(03)00980-X |
0.522 |
|
| 2003 |
Ridley JM, Milnes JT, Zhang YH, Witchel HJ, Hancox JC. Inhibition of HERG K+ current and prolongation of the guinea-pig ventricular action potential by 4-aminopyridine. The Journal of Physiology. 549: 667-72. PMID 12740430 DOI: 10.1113/jphysiol.2003.043976 |
0.468 |
|
| 2003 |
Zhang YH, Hancox JC. A novel, voltage-dependent nonselective cation current activated by insulin in guinea pig isolated ventricular myocytes. Circulation Research. 92: 765-8. PMID 12637365 DOI: 10.1161/01.RES.0000065920.64121.FC |
0.308 |
|
| 2003 |
Witchel HJ, Hancox JC, Nutt DJ, Wilson S. Antipsychotics, HERG and sudden death. The British Journal of Psychiatry : the Journal of Mental Science. 182: 171-2. PMID 12562748 DOI: 10.1192/Bjp.182.2.171-A |
0.419 |
|
| 2002 |
Borg JJ, Yuill KH, Hancox JC, Spencer IC, Kozlowski RZ. Inhibitory effects of the antiestrogen agent clomiphene on cardiac sarcolemmal anionic and cationic currents. The Journal of Pharmacology and Experimental Therapeutics. 303: 282-92. PMID 12235262 DOI: 10.1124/JPET.102.038901 |
0.351 |
|
| 2002 |
Paul AA, Witchel HJ, Hancox JC. Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine. British Journal of Pharmacology. 136: 717-29. PMID 12086981 DOI: 10.1038/sj.bjp.0704784 |
0.393 |
|
| 2001 |
Paul AA, Witchel HJ, Hancox JC. Inhibition of HERG potassium channel current by the class 1a antiarrhythmic agent disopyramide. Biochemical and Biophysical Research Communications. 280: 1243-50. PMID 11162661 DOI: 10.1006/BBRC.2001.4269 |
0.528 |
|
| 2001 |
Witchel HJ, Hancox JC. Familial and acquired long qt syndrome and the cardiac rapid delayed rectifier potassium current. Clinical and Experimental Pharmacology & Physiology. 27: 753-66. PMID 11022966 DOI: 10.1046/j.1440-1681.2000.03337.x |
0.32 |
|
| 2000 |
Zhang YH, Hancox JC. Gadolinium inhibits Na(+)-Ca(2+) exchanger current in guinea-pig isolated ventricular myocytes. British Journal of Pharmacology. 130: 485-8. PMID 10821774 DOI: 10.1038/sj.bjp.0703353 |
0.302 |
|
| 1999 |
Teschemacher AG, Seward EP, Hancox JC, Witchel HJ. Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline British Journal of Pharmacology. 128: 479-485. PMID 10510461 DOI: 10.1038/sj.bjp.0702800 |
0.407 |
|
| 1999 |
Dooley PC, Hancox JC, Chapman RA. Effect of phosphorylation on L-type calcium current in ventricular myocytes dialysed with proteolytic enzymes. Clinical and Experimental Pharmacology & Physiology. 26: 109-16. PMID 10065330 |
0.329 |
|
| 1996 |
Mitcheson JS, Hancox JC, Levi AJ. Action potentials, ion channel currents and transverse tubule density in adult rabbit ventricular myocytes maintained for 6 days in cell culture Pflugers Archiv European Journal of Physiology. 431: 814-827. PMID 8927497 DOI: 10.1007/s004240050073 |
0.32 |
|
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