Wayne A. Hendrickson
Affiliations: | Biochemistry & Molecular Biophysics | Columbia University, New York, NY |
Area:
biological macromoleculesWebsite:
http://www.columbia.edu/cu/biology/faculty-data/wayne-hendrickson/faculty.htmlGoogle:
"Wayne A. Hendrickson"Bio:
http://www.nasonline.org/member-directory/members/54677.html
http://cpmcnet.columbia.edu/dept/gsas/biochem/faculty/hendrickson.html
http://convex.hhmi.columbia.edu/
Wayne A. Hendrickson is a University Professor at Columbia University in the Department of Biochemistry and Molecular Biophysics and Violin Family Professor of Physiology and Cellular Biophysics. He is also Chief Life Scientist in the Photon Sciences Directorate at Brookhaven National Laboratory and Scientific Director of the New York Structural Biology Center. Hendrickson has a B.A. from the University of Wisconsin at River Falls, a Ph.D. in biophysics at Johns Hopkins University with Warner Love, and postdoctoral research experience with Jerome Karle at the Naval Research Laboratory (NRL). He and his colleagues use biochemistry and x-ray crystallography to study molecular properties in atomic detail with current emphasis on membrane receptors and cellular signaling, on viral proteins and HIV infection, on molecular chaperones and protein folding, and on structural genomics of membrane proteins. Hendrickson's advances in diffraction methodology have contributed significantly to the emergence of structural biology as a major force in modern biology and molecular medicine.
His honors include the Aminoff Prize of the Royal Swedish Academy of Sciences, the Gairdner International Award, and the Harvey Prize of the Technion – Israel Institute of Technology. He is a fellow of the American Academy of Arts and Sciences and a member of the National Academy of Sciences.
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Cross-listing: Chemistry Tree
Parents
Sign in to add mentorWarner E. Love | grad student | 1968 | Johns Hopkins (Chemistry Tree) | |
(The crystal forms of lamprey hemoglobin and crystalline transitions between ligand states) | ||||
Jerome Karle | post-doc | 1969-1971 | Naval Research Laboratory |
Children
Sign in to add traineeLawrence S. Shapiro | grad student | Columbia (Neurotree) | |
M. Hunter Giese | grad student | 2015- | Columbia (Chemistry Tree) |
Guanqi Lu | grad student | 2021- | (Chemistry Tree) |
Wei Yang | grad student | 1991 | Columbia |
John R Horton | grad student | 1992 | Columbia (Chemistry Tree) |
Deborah J. Stauber | grad student | 2000 | Columbia (Chemistry Tree) |
Paul J. Lee | grad student | 2004 | Columbia (Chemistry Tree) |
Jonah Cheung | grad student | 2005 | Columbia (Chemistry Tree) |
Danmei Huang | grad student | 2005 | Columbia (Chemistry Tree) |
Hepan Tan | grad student | 2006 | Columbia (Chemistry Tree) |
Hui Xie | grad student | 2006 | Columbia (Chemistry Tree) |
Betty N. Slama | grad student | 2008 | Columbia (Chemistry Tree) |
Gabriel G. Gregorio | grad student | 2009 | Columbia (Chemistry Tree) |
Anil Korkut | grad student | 2009 | Columbia (Chemistry Tree) |
Mark N. Collins | grad student | 2010 | Columbia (Chemistry Tree) |
Marisa G. Evelyn | grad student | 2010 | Columbia (Chemistry Tree) |
Matthew Le-Khac | grad student | 2013 | Columbia (Chemistry Tree) |
Craig A. Bingman | post-doc | (Chemistry Tree) | |
Ruben Diaz-Avalos | post-doc | Columbia (Chemistry Tree) | |
Millie M. Georgiadis | post-doc | (Chemistry Tree) | |
Rhett Kovall | post-doc | (Microtree) | |
Janet L. Smith | post-doc | Naval Research Laboratory (Cell Biology Tree) | |
John Charles Williams | post-doc | Columbia College of Physicians and Surgeons (Chemistry Tree) | |
Zhen Gong | post-doc | 2016- | (Chemistry Tree) |
shuobing chen | post-doc | 2017- | Columbia University Irving Medical Center (Chemistry Tree) |
Chi Wang | post-doc | 2022- | Columbia (Chemistry Tree) |
Keith B Ward | post-doc | 1974-1976 | Naval Research Laboratory (Chemistry Tree) |
Martha M Teeter | post-doc | 1976-1977 | Naval Research Laboratory (Chemistry Tree) |
William E. Royer | post-doc | 1990 | Columbia (Chemistry Tree) |
William Weis | post-doc | 1989-1992 | Columbia (Chemistry Tree) |
Hao Wu | post-doc | 1997 | Columbia (Chemistry Tree) |
Daved H. Fremont | post-doc | 1994-1998 | Columbia (Chemistry Tree) |
Youzhong Guo | post-doc | 2010 | Columbia (Chemistry Tree) |
Publications
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Qiu W, Trinh TKH, Catalano C, et al. (2025) Cholesterol-dependent enzyme activity of human TSPO1. Proceedings of the National Academy of Sciences of the United States of America. 122: e2323045122 |
Hendrickson WA, Gong Z. (2025) Structural and evolutionary insights into the functioning of glycoprotein hormones and their receptors. Andrology |
Gong Z, Chen S, Fu Z, et al. (2025) Structure of an LGR dimer - an evolutionary predecessor of glycoprotein hormone receptors. Biorxiv : the Preprint Server For Biology |
Wang W, Gong Z, Hendrickson WA. (2025) AlphaFold-guided molecular replacement for solving challenging crystal structures. Acta Crystallographica. Section D, Structural Biology |
Zuo H, Park J, Frangaj A, et al. (2024) Promiscuous G-protein activation by the calcium-sensing receptor. Nature |
Lu B, Ohayon YP, Woloszyn K, et al. (2023) Heterobimetallic Base Pair Programming in Designer 3D DNA Crystals. Journal of the American Chemical Society |
Vecchioni S, Lu B, Livernois W, et al. (2023) Metal-Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction. Advanced Materials (Deerfield Beach, Fla.). e2210938 |
Fritschi CJ, Anang S, Gong Z, et al. (2023) Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 120: e2222073120 |
Vecchioni S, Lu B, Livernois W, et al. (2023) Metal-Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction. Advanced Materials (Deerfield Beach, Fla.). e2201938 |
Chaplain C, Fritschi CJ, Anang S, et al. (2022) Structural and Functional Characterization of Indane-Core CD4-Mimetic Compounds Substituted with Heterocyclic Amines. Acs Medicinal Chemistry Letters. 14: 51-58 |