Wayne A. Hendrickson

Affiliations: 
Biochemistry & Molecular Biophysics Columbia University, New York, NY 
Area:
biological macromolecules
Website:
http://www.columbia.edu/cu/biology/faculty-data/wayne-hendrickson/faculty.html
Google:
"Wayne A. Hendrickson"
Bio:

http://www.nasonline.org/member-directory/members/54677.html
http://cpmcnet.columbia.edu/dept/gsas/biochem/faculty/hendrickson.html
http://convex.hhmi.columbia.edu/
Wayne A. Hendrickson is a University Professor at Columbia University in the Department of Biochemistry and Molecular Biophysics and Violin Family Professor of Physiology and Cellular Biophysics. He is also Chief Life Scientist in the Photon Sciences Directorate at Brookhaven National Laboratory and Scientific Director of the New York Structural Biology Center. Hendrickson has a B.A. from the University of Wisconsin at River Falls, a Ph.D. in biophysics at Johns Hopkins University with Warner Love, and postdoctoral research experience with Jerome Karle at the Naval Research Laboratory (NRL). He and his colleagues use biochemistry and x-ray crystallography to study molecular properties in atomic detail with current emphasis on membrane receptors and cellular signaling, on viral proteins and HIV infection, on molecular chaperones and protein folding, and on structural genomics of membrane proteins. Hendrickson's advances in diffraction methodology have contributed significantly to the emergence of structural biology as a major force in modern biology and molecular medicine.

His honors include the Aminoff Prize of the Royal Swedish Academy of Sciences, the Gairdner International Award, and the Harvey Prize of the Technion – Israel Institute of Technology. He is a fellow of the American Academy of Arts and Sciences and a member of the National Academy of Sciences.
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Cross-listing: Chemistry Tree

Parents

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Warner E. Love grad student 1968 Johns Hopkins (Chemistry Tree)
 (The crystal forms of lamprey hemoglobin and crystalline transitions between ligand states)
Jerome Karle post-doc 1969-1971 Naval Research Laboratory

Children

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Lawrence S. Shapiro grad student Columbia (Neurotree)
M. Hunter Giese grad student 2015- Columbia (Chemistry Tree)
Guanqi Lu grad student 2021- (Chemistry Tree)
Wei Yang grad student 1991 Columbia
John R Horton grad student 1992 Columbia (Chemistry Tree)
Deborah J. Stauber grad student 2000 Columbia (Chemistry Tree)
Paul J. Lee grad student 2004 Columbia (Chemistry Tree)
Jonah Cheung grad student 2005 Columbia (Chemistry Tree)
Danmei Huang grad student 2005 Columbia (Chemistry Tree)
Hepan Tan grad student 2006 Columbia (Chemistry Tree)
Hui Xie grad student 2006 Columbia (Chemistry Tree)
Betty N. Slama grad student 2008 Columbia (Chemistry Tree)
Gabriel G. Gregorio grad student 2009 Columbia (Chemistry Tree)
Anil Korkut grad student 2009 Columbia (Chemistry Tree)
Mark N. Collins grad student 2010 Columbia (Chemistry Tree)
Marisa G. Evelyn grad student 2010 Columbia (Chemistry Tree)
Matthew Le-Khac grad student 2013 Columbia (Chemistry Tree)
Craig A. Bingman post-doc (Chemistry Tree)
Ruben Diaz-Avalos post-doc Columbia (Chemistry Tree)
Millie M. Georgiadis post-doc (Chemistry Tree)
Rhett Kovall post-doc (Microtree)
Janet L. Smith post-doc Naval Research Laboratory (Cell Biology Tree)
John Charles Williams post-doc Columbia College of Physicians and Surgeons (Chemistry Tree)
Zhen Gong post-doc 2016- (Chemistry Tree)
shuobing chen post-doc 2017- Columbia University Irving Medical Center (Chemistry Tree)
Chi Wang post-doc 2022- Columbia (Chemistry Tree)
Keith B Ward post-doc 1974-1976 Naval Research Laboratory (Chemistry Tree)
Martha M Teeter post-doc 1976-1977 Naval Research Laboratory (Chemistry Tree)
William E. Royer post-doc 1990 Columbia (Chemistry Tree)
William Weis post-doc 1989-1992 Columbia (Chemistry Tree)
Hao Wu post-doc 1997 Columbia (Chemistry Tree)
Daved H. Fremont post-doc 1994-1998 Columbia (Chemistry Tree)
Youzhong Guo post-doc 2010 Columbia (Chemistry Tree)

Collaborators

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Yoel Ohayon collaborator 2020- Columbia (Chemistry Tree)
BETA: Related publications

Publications

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Qiu W, Trinh TKH, Catalano C, et al. (2025) Cholesterol-dependent enzyme activity of human TSPO1. Proceedings of the National Academy of Sciences of the United States of America. 122: e2323045122
Hendrickson WA, Gong Z. (2025) Structural and evolutionary insights into the functioning of glycoprotein hormones and their receptors. Andrology
Gong Z, Chen S, Fu Z, et al. (2025) Structure of an LGR dimer - an evolutionary predecessor of glycoprotein hormone receptors. Biorxiv : the Preprint Server For Biology
Wang W, Gong Z, Hendrickson WA. (2025) AlphaFold-guided molecular replacement for solving challenging crystal structures. Acta Crystallographica. Section D, Structural Biology
Zuo H, Park J, Frangaj A, et al. (2024) Promiscuous G-protein activation by the calcium-sensing receptor. Nature
Lu B, Ohayon YP, Woloszyn K, et al. (2023) Heterobimetallic Base Pair Programming in Designer 3D DNA Crystals. Journal of the American Chemical Society
Vecchioni S, Lu B, Livernois W, et al. (2023) Metal-Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction. Advanced Materials (Deerfield Beach, Fla.). e2210938
Fritschi CJ, Anang S, Gong Z, et al. (2023) Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 120: e2222073120
Vecchioni S, Lu B, Livernois W, et al. (2023) Metal-Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction. Advanced Materials (Deerfield Beach, Fla.). e2201938
Chaplain C, Fritschi CJ, Anang S, et al. (2022) Structural and Functional Characterization of Indane-Core CD4-Mimetic Compounds Substituted with Heterocyclic Amines. Acs Medicinal Chemistry Letters. 14: 51-58
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