Gianluca Santoni
Affiliations: | Univ Grenoble Alpes |
Area:
Acetylcholinesterase, Crystallography, Molecular simulationsGoogle:
"Gianluca Santoni"Parents
Sign in to add mentor| Martin Weik | grad student | 2015 | Univ Grenoble Alpes | |
| (Structural dynamics of acetylcholinesterase and its implications in reactivators design) | ||||
BETA: Related publications
See more...
Publications
|
You can help our author matching system! If you notice any publications incorrectly attributed to this author, please sign in and mark matches as correct or incorrect. |
| Lalut J, Santoni G, Karila D, et al. (2018) Novel multitarget-directed ligands targeting acetylcholinesterase and σ receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase. European Journal of Medicinal Chemistry. 162: 234-248 |
| Santoni G, de Sousa J, De la Mora E, et al. (2018) Structure-based optimization of non-quaternary reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. Journal of Medicinal Chemistry |
| Dolles D, Hoffmann M, Gunesch S, et al. (2018) Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles. Journal of Medicinal Chemistry |
| Brazzolotto X, Igert A, Guillon V, et al. (2017) Bacterial Expression of Human Butyrylcholinesterase as a Tool for Nerve Agent Bioscavengers Development. Molecules (Basel, Switzerland). 22 |
| Kliachyna M, Santoni G, Nussbaum V, et al. (2014) Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- Aldoxime and -Amidoxime hybrids as efficient uncharged reactivators of nerve agent-Inhibited human acetylcholinesterase European Journal of Medicinal Chemistry. 78: 455-467 |
| Oueis E, Santoni G, Ronco C, et al. (2014) Reaction site-driven regioselective synthesis of AChE inhibitors Organic and Biomolecular Chemistry. 12: 156-161 |
| Carletti E, Colletier JP, Schopfer LM, et al. (2013) Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry. Chemical Research in Toxicology. 26: 280-9 |
| Quaglia W, Piergentili A, Del Bello F, et al. (2008) Structure-activity relationships in 1,4-benzodioxan-related compounds. 9. 1 From 1,4-benzodioxane to 1,4-dioxane ring as a promising template of novel α1D-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents Journal of Medicinal Chemistry. 51: 6359-6370 |
| Antonini I, Santoni G, Lucciarini R, et al. (2008) Synthesis and antitumor evaluation of bis aza-anthracene-9,10-diones and bis aza-anthrapyrazole-6-ones Journal of Medicinal Chemistry. 51: 997-1006 |
| Antonini I, Santoni G, Lucciarini R, et al. (2006) Synthesis and biological evaluation of new asymmetrical bisintercalators as potential antitumor drugs Journal of Medicinal Chemistry. 49: 7198-7207 |