Xiang Zhai, Ph.D.

Affiliations: 
2015 Chemistry State University of New York, Buffalo, Buffalo, NY, United States 
Area:
Biochemistry, Organic Chemistry
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"Xiang Zhai"

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John P. Richard grad student 2015 SUNY Buffalo
 (Triosephosphate isomerase as a mechanistic model for utilization of binding energy in enzyme catalysis: Activation and inhibition studies.)
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Publications

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Zhai X, Ward RA, Doig P, et al. (2020) Insight into the Therapeutic Selectivity of the Irreversible EGFR Tyrosine Kinase Inhibitor Osimertinib through Enzyme Kinetic Studies. Biochemistry
Zhai X, Reinhardt CJ, Malabanan MM, et al. (2018) Enzyme Architecture: Amino Acid Side Chains Which Function to Optimize the Basicity of the Active Site Glutamate of Triosephosphate Isomerase. Journal of the American Chemical Society
Zhai X, Meek TD. (2018) Catalytic Mechanism of Cruzain from Trypanosoma cruzi as Determined from Solvent Kinetic Isotope Effects of Steady-State and Pre-Steady-State Kinetics. Biochemistry
Amyes TL, Malabanan MM, Zhai X, et al. (2016) Enzyme activation through the utilization of intrinsic dianion binding energy. Protein Engineering, Design & Selection : Peds
Richard JP, Amyes TL, Malabanan MM, et al. (2016) Structure-Function Studies on Hydrophobic Residues that Clamp a Basic Glutamate Side-Chain During Catalysis by Triosephosphate Isomerase. Biochemistry
Zhai X, Amyes TL, Richard JP. (2015) The Role of Loop-Clamping Side Chains in Catalysis by Triosephosphate Isomerase. Journal of the American Chemical Society
Reyes AC, Zhai X, Morgan KT, et al. (2015) The activating oxydianion binding domain for enzyme-catalyzed proton transfer, hydride transfer, and decarboxylation: specificity and enzyme architecture. Journal of the American Chemical Society. 137: 1372-82
Reyes AC, Zhai X, Morgan KT, et al. (2015) The activating oxydianion binding domain for enzyme-catalyzed proton transfer, hydride transfer, and decarboxylation: Specificity and enzyme architecture Journal of the American Chemical Society. 137: 1372-1382
Richard JP, Zhai X, Malabanan MM. (2014) Reflections on the catalytic power of a TIM-barrel. Bioorganic Chemistry. 57: 206-12
Zhai X, Go MK, O'Donoghue AC, et al. (2014) Enzyme architecture: the effect of replacement and deletion mutations of loop 6 on catalysis by triosephosphate isomerase. Biochemistry. 53: 3486-501
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