Ernst ter Haar, Ph.D.

Vertex Pharmaceuticals, Boston, MA, United States 
"Ernst ter Haar"
Cross-listing: Chemistry Tree


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Billy W. Day grad student 1991-1995 University of Pittsburgh (Chemistry Tree)
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Capoferri L, Leth R, Ter Haar E, et al. (2016) Insights into regioselective metabolism of mefenamic acid by Cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations. Proteins
ter Haar E, Koth CM, Abdul-Manan N, et al. (2010) Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. Structure (London, England : 1993). 18: 1083-93
Aronov AM, Tang Q, Martinez-Botella G, et al. (2009) Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control. Journal of Medicinal Chemistry. 52: 6362-8
ter Haar E, Prabhakar P, Prabakhar P, et al. (2007) Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer. The Journal of Biological Chemistry. 282: 9733-9
Ter Haar E. (2006) The Crystal Structures of Glycogen Synthase Kinase 3 Glycogen Synthase Kinase 3 (Gsk-3) and Its Inhibitors: Drug Discovery and Development. 61-82
Pierce AC, ter Haar E, Binch HM, et al. (2005) CH...O and CH...N hydrogen bonds in ligand design: a novel quinazolin-4-ylthiazol-2-ylamine protein kinase inhibitor. Journal of Medicinal Chemistry. 48: 1278-81
ter Haar E, Walters WP, Pazhanisamy S, et al. (2004) Kinase chemogenomics: targeting the human kinome for target validation and drug discovery. Mini Reviews in Medicinal Chemistry. 4: 235-53
ter Haar E. (2003) Activating MAP KAP kinase 2. Structure (London, England : 1993). 11: 611-2
ter Haar E, Coll JT, Austen DA, et al. (2001) Structure of GSK3beta reveals a primed phosphorylation mechanism. Nature Structural Biology. 8: 593-6
ter Haar E, Harrison SC, Kirchhausen T. (2000) Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin. Proceedings of the National Academy of Sciences of the United States of America. 97: 1096-100
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