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Michael D. Varnum - Publications

Affiliations: 
Washington State University, Pullman, WA, United States 
Area:
Ion Channels
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33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Meighan PC, Peng C, Varnum MD. Inherited macular degeneration-associated mutations in CNGB3 increase the ligand sensitivity and spontaneous open probability of cone cyclic nucleotide-gated channels. Frontiers in Physiology. 6: 177. PMID 26106334 DOI: 10.3389/Fphys.2015.00177  0.672
2014 Dai G, Sherpa T, Varnum MD. Alternative splicing governs cone cyclic nucleotide-gated (CNG) channel sensitivity to regulation by phosphoinositides. The Journal of Biological Chemistry. 289: 13680-90. PMID 24675082 DOI: 10.1074/Jbc.M114.562272  0.81
2013 Meighan SE, Meighan PC, Rich ED, Brown RL, Varnum MD. Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating. Biochemistry. 52: 8352-62. PMID 24164424 DOI: 10.1021/Bi400824X  0.562
2013 Liu C, Sherpa T, Varnum MD. Disease-associated mutations in CNGB3 promote cytotoxicity in photoreceptor-derived cells. Molecular Vision. 19: 1268-81. PMID 23805033  0.66
2013 Dai G, Varnum MD. CNGA3 achromatopsia-associated mutation potentiates the phosphoinositide sensitivity of cone photoreceptor CNG channels by altering intersubunit interactions. American Journal of Physiology. Cell Physiology. 305: C147-59. PMID 23552282 DOI: 10.1152/Ajpcell.00037.2013  0.808
2013 Dai G, Peng C, Liu C, Varnum MD. Two structural components in CNGA3 support regulation of cone CNG channels by phosphoinositides. The Journal of General Physiology. 141: 413-30. PMID 23530136 DOI: 10.1085/Jgp.201210944  0.768
2013 Dai G, Peng C, Rich E, Varnum MD. Distinct Contributions of CNGA3 and CNGB3 Subunits to Ligand-Specific Activation of Cone CNG Channels Biophysical Journal. 104: 278a. DOI: 10.1016/J.Bpj.2012.11.1559  0.803
2012 Meighan PC, Meighan SE, Rich ED, Brown RL, Varnum MD. Matrix metalloproteinase-9 and -2 enhance the ligand sensitivity of photoreceptor cyclic nucleotide-gated channels. Channels (Austin, Tex.). 6: 181-96. PMID 22699690 DOI: 10.4161/Chan.20904  0.612
2012 Duricka DL, Brown RL, Varnum MD. Defective trafficking of cone photoreceptor CNG channels induces the unfolded protein response and ER-stress-associated cell death. The Biochemical Journal. 441: 685-96. PMID 21992067 DOI: 10.1042/Bj20111004  0.778
2012 Dai G, Sherpa T, Rich E, Mills D, Peng C, Varnum MD. Alternative Splicing for CNGA3 Controls Channel Sensitivity to Regulation by Phosphoinositides Biophysical Journal. 102: 131a. DOI: 10.1016/J.Bpj.2011.11.728  0.809
2012 Meighan PC, Meighan SE, Rich ED, Brown RL, Varnum MD. Matrix Metalloproteinase-9 Increases the Ligand Sensitivity of CNG Channels: Evidence for Sequential Subunit Modification Biophysical Journal. 102: 131a. DOI: 10.1016/J.Bpj.2011.11.727  0.561
2010 Dai G, Rich E, Brown L, Varnum M. Subunit-Specific Regulation of Photoreceptor CNG Channels by Phosphoinositides Biophysical Journal. 98: 707a. DOI: 10.1016/J.Bpj.2009.12.3877  0.78
2007 Bright SR, Rich ED, Varnum MD. Regulation of human cone cyclic nucleotide-gated channels by endogenous phospholipids and exogenously applied phosphatidylinositol 3,4,5-trisphosphate. Molecular Pharmacology. 71: 176-83. PMID 17018579 DOI: 10.1124/Mol.106.026401  0.835
2006 Brady JD, Rich ED, Martens JR, Karpen JW, Varnum MD, Brown RL. Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels. Proceedings of the National Academy of Sciences of the United States of America. 103: 15635-40. PMID 17032767 DOI: 10.1073/Pnas.0603344103  0.714
2005 Bright SR, Brown TE, Varnum MD. Disease-associated mutations in CNGB3 produce gain of function alterations in cone cyclic nucleotide-gated channels. Molecular Vision. 11: 1141-50. PMID 16379026  0.809
2005 Liu C, Varnum MD. Functional consequences of progressive cone dystrophy-associated mutations in the human cone photoreceptor cyclic nucleotide-gated channel CNGA3 subunit. American Journal of Physiology. Cell Physiology. 289: C187-98. PMID 15743887 DOI: 10.1152/Ajpcell.00490.2004  0.67
2004 Peng C, Rich ED, Varnum MD. Subunit configuration of heteromeric cone cyclic nucleotide-gated channels. Neuron. 42: 401-10. PMID 15134637 DOI: 10.1016/S0896-6273(04)00225-9  0.512
2003 Zheng J, Varnum MD, Zagotta WN. Disruption of an intersubunit interaction underlies Ca2+-calmodulin modulation of cyclic nucleotide-gated channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8167-75. PMID 12954880 DOI: 10.1523/Jneurosci.23-22-08167.2003  0.791
2003 Peng C, Rich ED, Varnum MD. Achromatopsia-associated mutation in the human cone photoreceptor cyclic nucleotide-gated channel CNGB3 subunit alters the ligand sensitivity and pore properties of heteromeric channels. The Journal of Biological Chemistry. 278: 34533-40. PMID 12815043 DOI: 10.1074/Jbc.M305102200  0.677
2003 Peng C, Rich ED, Thor CA, Varnum MD. Functionally important calmodulin-binding sites in both NH2- and COOH-terminal regions of the cone photoreceptor cyclic nucleotide-gated channel CNGB3 subunit. The Journal of Biological Chemistry. 278: 24617-23. PMID 12730238 DOI: 10.1074/Jbc.M301699200  0.666
1997 Varnum MD, Zagotta WN. Interdomain interactions underlying activation of cyclic nucleotide-gated channels. Science (New York, N.Y.). 278: 110-3. PMID 9311913 DOI: 10.1126/science.278.5335.110  0.82
1997 Gordon SE, Varnum MD, Zagotta WN. Direct interaction between amino- and carboxyl-terminal domains of cyclic nucleotide-gated channels. Neuron. 19: 431-41. PMID 9292731 DOI: 10.1016/S0896-6273(00)80951-4  0.813
1996 Varnum MD, Zagotta WN. Subunit interactions in the activation of cyclic nucleotide-gated ion channels. Biophysical Journal. 70: 2667-79. PMID 8744304 DOI: 10.1016/S0006-3495(96)79836-3  0.835
1996 Gordon SE, Oakley JC, Varnum MD, Zagotta WN. Altered ligand specificity by protonation in the ligand binding domain of cyclic nucleotide-gated channels. Biochemistry. 35: 3994-4001. PMID 8672432 DOI: 10.1021/bi952607b  0.836
1995 Varnum MD, Maylie J, Busch A, Adelman JP. Persistent activation of min K channels by chemical cross-linking. Neuron. 14: 407-12. PMID 7857648 DOI: 10.1016/0896-6273(95)90296-1  0.684
1995 Varnum MD, Black KD, Zagotta WN. Molecular mechanism for ligand discrimination of cyclic nucleotide-gated channels. Neuron. 15: 619-25. PMID 7546741 DOI: 10.1016/0896-6273(95)90150-7  0.786
1994 Busch AE, Malloy K, Groh WJ, Varnum MD, Adelman JP, Maylie J. The novel class III antiarrhythmics NE-10064 and NE-10133 inhibit IsK channels expressed in Xenopus oocytes and IKs in guinea pig cardiac myocytes. Biochemical and Biophysical Research Communications. 202: 265-70. PMID 8037721 DOI: 10.1006/bbrc.1994.1922  0.682
1993 Varnum MD, Busch AE, Bond CT, Maylie J, Adelman JP. The min K channel underlies the cardiac potassium current IKs and mediates species-specific responses to protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 90: 11528-32. PMID 8265583 DOI: 10.1073/Pnas.90.24.11528  0.584
1992 Busch AE, Varnum MD, North RA, Adelman JP. An amino acid mutation in a potassium channel that prevents inhibition by protein kinase C. Science (New York, N.Y.). 255: 1705-7. PMID 1553557 DOI: 10.1126/Science.1553557  0.699
1992 Kavanaugh MP, Hurst RS, Yakel J, Varnum MD, Adelman JP, North RA. Multiple subunits of a voltage-dependent potassium channel contribute to the binding site for tetraethylammonium. Neuron. 8: 493-7. PMID 1550674 DOI: 10.1016/0896-6273(92)90277-K  0.769
1992 Busch AE, Kavanaugh MP, Varnum MD, Adelman JP, North RA. Regulation by second messengers of the slowly activating, voltage-dependent potassium current expressed in Xenopus oocytes. The Journal of Physiology. 450: 491-502. PMID 1432714 DOI: 10.1113/Jphysiol.1992.Sp019138  0.511
1992 Busch AE, Varnum M, Adelman JP, North RA. Hypotonic solution increases the slowly activating potassium current IsK expressed in xenopus oocytes. Biochemical and Biophysical Research Communications. 184: 804-10. PMID 1374241 DOI: 10.1016/0006-291X(92)90661-4  0.481
1991 Kavanaugh MP, Varnum MD, Osborne PB, Christie MJ, Busch AE, Adelman JP, North RA. Interaction between tetraethylammonium and amino acid residues in the pore of cloned voltage-dependent potassium channels. The Journal of Biological Chemistry. 266: 7583-7. PMID 2019588  0.768
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