| Year |
Citation |
Score |
| 2007 |
Johnson EC, Malito E, Shen Y, Rich D, Tang WJ, Kent SB. Modular total chemical synthesis of a human immunodeficiency virus type 1 protease. Journal of the American Chemical Society. 129: 11480-90. PMID 17705484 DOI: 10.1021/Ja072870N |
0.303 |
|
| 2005 |
Haug BE, Brewer M, Rich DH. Facile degradative lactonization of Gln-Arg and Gln-Phe hydroxyethylene dipeptide derivatives. The Journal of Peptide Research : Official Journal of the American Peptide Society. 65: 77-83. PMID 15759328 DOI: 10.1111/J.1399-3011.2004.00208.X |
0.654 |
|
| 2004 |
Haug BE, Rich DH. Synthesis of a Gln-Phe hydroxy-ethylene dipeptide isostere. Organic Letters. 6: 4783-6. PMID 15575685 DOI: 10.1021/Ol047879Y |
0.436 |
|
| 2004 |
Brewer M, James CA, Rich DH. Synthesis of a tripeptide derivative containing the gln-arg hydroxyethylene dipeptide isostere. Organic Letters. 6: 4779-82. PMID 15575684 DOI: 10.1021/Ol047880X |
0.783 |
|
| 2004 |
Sukonpan C, Oost T, Goodnough M, Tepp W, Johnson EA, Rich DH. Synthesis of substrates and inhibitors of botulinum neurotoxin type A metalloprotease. The Journal of Peptide Research : Official Journal of the American Peptide Society. 63: 181-93. PMID 15009541 DOI: 10.1111/J.1399-3011.2004.00124.X |
0.812 |
|
| 2003 |
Oost T, Sukonpan C, Brewer M, Goodnough M, Tepp W, Johnson EA, Rich DH. Design and synthesis of substrate-based inhibitors of botulinum neurotoxin type B metalloprotease. Biopolymers. 71: 602-19. PMID 14991672 DOI: 10.1002/Bip.10590 |
0.793 |
|
| 2003 |
Estiarte MA, Rich DH. Peptidomimetics for Drug Design Burger's Medicinal Chemistry and Drug Discovery. 633-685. DOI: 10.1002/0471266949.Bmc014 |
0.389 |
|
| 2002 |
Rich DH, Bursavich MG, Estiarte MA. Discovery of nonpeptide, peptidomimetic peptidase inhibitors that target alternate enzyme active site conformations. Biopolymers. 66: 115-25. PMID 12325161 DOI: 10.1002/Bip.10231 |
0.727 |
|
| 2002 |
Brewer M, Oost T, Sukonpan C, Pereckas M, Rich DH. Sequencing hydroxyethylamine-containing peptides via Edman degradation. Organic Letters. 4: 3469-72. PMID 12323046 DOI: 10.1021/Ol026590I |
0.765 |
|
| 2002 |
Bursavich MG, Rich DH. Designing non-peptide peptidomimetics in the 21st century: inhibitors targeting conformational ensembles. Journal of Medicinal Chemistry. 45: 541-58. PMID 11806706 DOI: 10.1021/Jm010425B |
0.744 |
|
| 2002 |
RICH D, TAM J. A Convenient Synthesis of the Amino Acid, 1-Aminocyclopropane-1-carboxylic Acid Synthesis. 1978: 46-46. DOI: 10.1055/S-1978-24668 |
0.325 |
|
| 2002 |
Rich DH, Moon BJ, Boparai AS. Synthesis of (2S,3R)-3-amino-2-hydroxy-5-methylhexanoic acid derivatives. Application to the synthesis of amastatin, an inhibitor of aminopeptidases Cheminform. 11. DOI: 10.1021/Jo01300A004 |
0.405 |
|
| 2002 |
Oost TK, Sukonpan C, Rich DH, Stevens RC. Structural Basis for BABIM Inhibition of Botulinum Neurotoxin Type B Protease [J. Am. Chem. Soc.2000,122, 11268−11269]. Journal of the American Chemical Society. 124: 10248-10248. DOI: 10.1021/Ja025109G |
0.762 |
|
| 2001 |
Travins JM, Bursavich MG, Veber DF, Rich DH. Aspartic protease inhibitors: expedient synthesis of 2-substituted statines. Organic Letters. 3: 2725-8. PMID 11506619 DOI: 10.1021/Ol016331D |
0.772 |
|
| 2001 |
Bursavich MG, Rich DH. Solid-phase synthesis of aspartic peptidase inhibitors: 3-alkoxy-4-aryl piperidines. Organic Letters. 3: 2625-8. PMID 11506594 DOI: 10.1021/Ol016280K |
0.767 |
|
| 2001 |
Bursavich MG, West CW, Rich DH. From peptides to non-peptide peptidomimetics: design and synthesis of new piperidine inhibitors of aspartic peptidases. Organic Letters. 3: 2317-20. PMID 11463305 DOI: 10.1021/Ol016092U |
0.817 |
|
| 2001 |
Dales NA, Bohacek RS, Satyshur KA, Rich DH. Design and synthesis of unsymmetrical peptidyl urea inhibitors of aspartic peptidases. Organic Letters. 3: 2313-6. PMID 11463304 DOI: 10.1021/Ol0160912 |
0.352 |
|
| 2001 |
Ripka AS, Satyshur KA, Bohacek RS, Rich DH. Aspartic protease inhibitors designed from computer-generated templates bind as predicted. Organic Letters. 3: 2309-12. PMID 11463303 DOI: 10.1021/Ol016090+ |
0.343 |
|
| 2001 |
West CW, Estiarte MA, Rich DH. New methods for side-chain protection of cysteine. Organic Letters. 3: 1205-8. PMID 11348195 DOI: 10.1021/Ol015678D |
0.675 |
|
| 2001 |
Brewer M, Rich DH. Synthesis of a tripeptide derivative containing the Phe-Arg hydroxyethylene dipeptide isostere. Organic Letters. 3: 945-8. PMID 11263922 DOI: 10.1021/ol015612i |
0.777 |
|
| 2000 |
Hanson MA, Oost TK, Sukonpan C, Rich DH, Stevens RC. Structural basis for BABIM inhibition of botulinum neurotoxin type B protease [22] Journal of the American Chemical Society. 122: 11268-11269. DOI: 10.1021/Ja005533M |
0.762 |
|
| 1999 |
West CW, Rich DH. Novel cyclic tripeptides and substituted aromatic amino acids via ruthenium-activated S(N)Ar reactions. Organic Letters. 1: 1819-22. PMID 10836040 DOI: 10.1021/Ol991084N |
0.667 |
|
| 1999 |
Elder AM, Rich DH. Two syntheses of the 16- and 17-membered DEF ring systems of chloropeptin and complestatin. Organic Letters. 1: 1443-6. PMID 10825992 DOI: 10.1021/Ol990990X |
0.74 |
|
| 1999 |
Flentke GR, Glinski J, Satyshur K, Rich DH. Purification and crystallization of rhizopuspepsin: the use of nickel chelation chromatography to select for catalytically active species. Protein Expression and Purification. 16: 213-20. PMID 10419816 DOI: 10.1006/Prep.1999.1078 |
0.383 |
|
| 1998 |
Raman P, Stokes SS, Angell YM, Flentke GR, Rich DH. Methods to Circumvent a Difficult Coupling in the Solid-Phase Synthesis of Cyclosporine Analogues. The Journal of Organic Chemistry. 63: 5734-5735. PMID 11672164 DOI: 10.1021/Jo980889Q |
0.723 |
|
| 1998 |
Ripka AS, Bohacek RS, Rich DH. Synthesis of novel cyclic protease inhibitors using Grubbs olefin metathesis. Bioorganic & Medicinal Chemistry Letters. 8: 357-60. PMID 9871684 DOI: 10.1016/S0960-894X(98)00025-0 |
0.403 |
|
| 1998 |
Keding SJ, Dales NA, Lim S, Beaulieu D, Rich DH. Synthesis of (3R)-amino-(2S)-hydroxy amino acids for inhibition of methionine aminopeptidase-1 Synthetic Communications. 28: 4463-4470. DOI: 10.1080/00397919808004481 |
0.777 |
|
| 1997 |
Janetka JW, Rich DH. Total synthesis of the cyclic biphenyl ether peptides K-13 and OF494-III via S(N)Ar macrocyclizations of peptidyl ruthenium π-arene complexes Journal of the American Chemical Society. 119: 6488-6495. DOI: 10.1021/Ja970614C |
0.686 |
|
| 1997 |
Janetka JW, Raman P, Satyshur K, Flentke GR, Rich DH. Novel cyclic biphenyl ether peptide β-strand mimetics and HIV-protease inhibitors Journal of the American Chemical Society. 119: 441-442. DOI: 10.1021/Ja963495U |
0.664 |
|
| 1997 |
Rich DH, Bohacek RS, Dales NA, Glunz P, Ripka AS. Transformation of peptides into non-peptides. Synthesis of computer-generated enzyme inhibitors Chimia. 51: 45-47. |
0.334 |
|
| 1996 |
Janetka JW, Satyshur KA, Rich DH. A cyclic side-chain-linked biphenyl ether tripeptide: H3N(+)-cyclo-[Phe(4-O)Phe-Phe(3-O)]-OMe.Cl-. Acta Crystallographica. Section C, Crystal Structure Communications. 52: 3112-4. PMID 9015901 |
0.575 |
|
| 1996 |
Meara JP, Rich DH. Mechanistic studies on the inactivation of papain by epoxysuccinyl inhibitors. Journal of Medicinal Chemistry. 39: 3357-66. PMID 8765519 DOI: 10.1021/Jm950445B |
0.436 |
|
| 1996 |
Solomon ME, Lynch CL, Rich DH. Efficient synthesis of tosyl-aziridine-2-t-butyl carboxylate Synthetic Communications. 26: 2723-2729. DOI: 10.1080/00397919608004589 |
0.339 |
|
| 1996 |
Janetka JW, Satyshur KA, Rich DH. A cyclic side-chain-linked biphenyl ether tripeptide: H3N+-cyclo-[Phe(4-0)-Phe-Phe (3-0)]-OMe.Cl- Acta Crystallographica Section C: Crystal Structure Communications. 52: 3112-3114. |
0.596 |
|
| 1995 |
Peranteau AG, Kuzmic P, Angell Y, García-Echeverría C, Rich DH. Increase in fluorescence upon the hydrolysis of tyrosine peptides: application to proteinase assays. Analytical Biochemistry. 227: 242-5. PMID 7668386 DOI: 10.1006/Abio.1995.1276 |
0.374 |
|
| 1995 |
Katz BA, Finer-Moore J, Mortezaei R, Rich DH, Stroud RM. Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface. Biochemistry. 34: 8264-80. PMID 7599119 DOI: 10.1021/Bi00026A008 |
0.345 |
|
| 1995 |
Hu MK, Badger A, Rich DH. Cyclosporin analogs modified in the 3,7,8-positions: substituent effects on peptidylprolyl isomerase inhibition and immunosuppressive activity are nonadditive. Journal of Medicinal Chemistry. 38: 4164-70. PMID 7473543 DOI: 10.1021/Jm00021A005 |
0.349 |
|
| 1995 |
Janetka JW, Rich DH. Synthesis of peptidyl ruthenium .pi.-arene complexes: application to the synthesis of cyclic biphenyl ether peptides. Journal of the American Chemical Society. 117: 10585-10586. DOI: 10.1021/Ja00147A026 |
0.704 |
|
| 1995 |
Angell YM, Thomas TL, Flentke GR, Rich DH. Solid-phase synthesis of cyclosporin peptides Journal of the American Chemical Society. 117: 7279-7280. DOI: 10.1021/Ja00132A042 |
0.411 |
|
| 1995 |
Solomon ME, Lynch CL, Rich DH. Synthesis of Nα, Nβ-alkylated diaminopropionic acid analogs Tetrahedron Letters. 36: 4955-4958. DOI: 10.1016/0040-4039(95)00968-I |
0.312 |
|
| 1995 |
García-Echeverría C, Rich DH. Kinetic studies of papain: Effect of P3′ substituents and donor/acceptor pairs of intramolecularly quenched fluorogenic substrates Letters in Peptide Science. 2: 77-82. DOI: 10.1007/Bf00128501 |
0.346 |
|
| 1995 |
Janetka JW, Rich DH. Synthesis of peptidyl ruthenium π-arene complexes: Application to the synthesis of cyclic biphenyl ether peptides Journal of the American Chemical Society. 117: 10585-10586. |
0.679 |
|
| 1994 |
Oliyai R, Safadi M, Meier PG, Hu MK, Rich DH, Stella VJ. Kinetics of acid-catalyzed degradation of cyclosporin A and its analogs in aqueous solution. International Journal of Peptide and Protein Research. 43: 239-47. PMID 8005746 DOI: 10.1111/J.1399-3011.1994.Tb00386.X |
0.328 |
|
| 1994 |
Romeo S, Rich DH. Stereoselective synthesis of protected amino alkyl epoxides Tetrahedron Letters. 35: 4939-4942. DOI: 10.1016/S0040-4039(00)73287-4 |
0.422 |
|
| 1994 |
Angell YM, García-Echeverría C, Rich DH. Comparative studies of the coupling of N-methylated, sterically hindered amino acids during solid-phase peptide synthesis Tetrahedron Letters. 35: 5981-5984. DOI: 10.1016/0040-4039(94)88054-9 |
0.43 |
|
| 1993 |
Wiley RA, Rich DH. Peptidomimetics derived from natural products. Medicinal Research Reviews. 13: 327-84. PMID 8483337 DOI: 10.1002/Med.2610130305 |
0.311 |
|
| 1993 |
García-Echeverría C, Kofron JL, Kuzmic P, Rich DH. A continuous spectrophotometric direct assay for peptidyl prolyl cis-trans isomerases. Biochemical and Biophysical Research Communications. 191: 70-5. PMID 8447837 DOI: 10.1006/Bbrc.1993.1185 |
0.312 |
|
| 1993 |
García-Echeverría C, Rich DH. Synthesis and fluorescence properties of a substrate for a continuous fluorimetric assay of protein tyrosine phosphatases Bioorganic and Medicinal Chemistry Letters. 3: 1601-1604. DOI: 10.1016/S0960-894X(00)80025-6 |
0.375 |
|
| 1993 |
Bohnstedt AC, Prasad JVNV, Rich DH. Synthesis of E- and Z-alkene dipeptide isosteres Tetrahedron Letters. 34: 5217-5220. DOI: 10.1016/S0040-4039(00)73956-6 |
0.343 |
|
| 1992 |
Ocain TD, Rich DH. alpha-Keto amide inhibitors of aminopeptidases. Journal of Medicinal Chemistry. 35: 451-6. PMID 1738140 DOI: 10.1021/Jm00081A005 |
0.381 |
|
| 1992 |
Lin HB, Zhao ZC, Garcia-Echeverria C, Rich DH, Cooper SL. Synthesis of a novel polyurethane co-polymer containing covalently attached RGD peptide. Journal of Biomaterials Science. Polymer Edition. 3: 217-27. PMID 1610732 DOI: 10.1163/156856292X00132 |
0.431 |
|
| 1992 |
García-Echeverría C, Rich DH. New intramolecularly quenched fluorogenic peptide substrates for the study of the kinetic specificity of papain. Febs Letters. 297: 100-2. PMID 1551413 DOI: 10.1016/0014-5793(92)80336-F |
0.404 |
|
| 1992 |
García-Echeverría C, Rich DH. Effect of P2' substituents on kinetic constants for hydrolysis by cysteine proteinases. Biochemical and Biophysical Research Communications. 187: 615-9. PMID 1530620 DOI: 10.1016/0006-291X(92)91239-M |
0.414 |
|
| 1992 |
Szewczuk Z, Rebholz KL, Rich DH. Synthesis and biological activity of new conformationally restricted analogues of pepstatin. International Journal of Peptide and Protein Research. 40: 233-42. PMID 1478780 DOI: 10.1111/J.1399-3011.1992.Tb00296.X |
0.478 |
|
| 1992 |
Rich DH, Prasad JV, Sun CQ, Green J, Mueller R, Houseman K, MacKenzie D, Malkovsky M. New hydroxyethylamine HIV protease inhibitors that suppress viral replication. Journal of Medicinal Chemistry. 35: 3803-12. PMID 1433192 DOI: 10.1021/Jm00099A008 |
0.334 |
|
| 1992 |
Kofron JL, Kuzmic P, Kishore V, Gemmecker G, Fesik SW, Rich DH. Lithium chloride perturbation of cis-trans peptide bond equilibria: Effect on conformational equilibria in cyclosporin A and on time-dependent inhibition of cyclophilin Journal of the American Chemical Society. 114: 2670-2675. DOI: 10.1021/Ja00033A047 |
0.39 |
|
| 1991 |
Kuzmic P, Sun CQ, Zhao ZC, Rich DH. Nonspecific electrostatic binding of substrates and inhibitors to porcine pepsin. Advances in Experimental Medicine and Biology. 306: 75-86. PMID 1812761 DOI: 10.1007/978-1-4684-6012-4_7 |
0.307 |
|
| 1991 |
Vara Prasad JVN, Rich DH. Synthesis of hydroxyethylene dipeptide isosteres that mimic a cyclic amino acid at the P1′ subsite Tetrahedron Letters. 32: 5857-5860. DOI: 10.1016/S0040-4039(00)79410-X |
0.367 |
|
| 1990 |
Lee JP, Dunlap B, Rich DH. Synthesis and immunosuppressive activities of conformationally restricted cyclosporin lactam analogues. International Journal of Peptide and Protein Research. 35: 481-94. PMID 2376472 DOI: 10.1111/J.1399-3011.1990.Tb00076.X |
0.363 |
|
| 1990 |
Sun CQ, Guillaume D, Dunlap B, Rich DH. Synthesis, conformation, and immunosuppressive activity of cyclosporines that contain epsilon-oxygen (4R)-4-[(E)-butenyl]-4,N-dimethyl-L-threonine analogues in the 1-position. Journal of Medicinal Chemistry. 33: 1443-52. PMID 2329566 DOI: 10.1021/Jm00167A026 |
0.419 |
|
| 1990 |
Aebi JD, Deyo DT, Sun CQ, Guillaume D, Dunlap B, Rich DH. Synthesis, conformation, and immunosuppressive activities of three analogues of cyclosporin A modified in the 1-position. Journal of Medicinal Chemistry. 33: 999-1009. PMID 2308150 DOI: 10.1021/Jm00165A018 |
0.391 |
|
| 1990 |
Swain AL, Miller MM, Green J, Rich DH, Schneider J, Kent SB, Wlodawer A. X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 87: 8805-9. PMID 2247451 DOI: 10.1073/Pnas.87.22.8805 |
0.376 |
|
| 1990 |
Rich DH, Green J, Toth MV, Marshall GR, Kent SB. Hydroxyethylamine analogues of the p17/p24 substrate cleavage site are tight-binding inhibitors of HIV protease. Journal of Medicinal Chemistry. 33: 1285-8. PMID 2184237 DOI: 10.1021/Jm00167A003 |
0.319 |
|
| 1990 |
Colucci WJ, Tung RD, Petri JA, Rich DH. Synthesis of D-lysine8-cyclosporine A. Further characterization of BOP-Cl in the 2-7 hexapeptide fragment synthesis Journal of Organic Chemistry. 55: 2895-2903. DOI: 10.1021/Jo00296A061 |
0.327 |
|
| 1989 |
Rich DH, Sun CQ, Guillaume D, Dunlap B, Evans DA, Weber AE. Synthesis, biological activity, and conformational analysis of (2S,3R,4S)-MeBmt1-cyclosporin, a novel 1-position epimer of cyclosporin A. Journal of Medicinal Chemistry. 32: 1982-7. PMID 2754718 DOI: 10.1021/Jm00128A048 |
0.399 |
|
| 1989 |
Maibaum J, Rich DH. Synthesis of the novel pi-(benzyloxymethyl)-protected histidine analogue of statine. Inhibition of penicillopepsin by pepstatin-derived peptides containing different statine side-chain derivatives. Journal of Medicinal Chemistry. 32: 1571-6. PMID 2661819 DOI: 10.1021/Jm00127A028 |
0.48 |
|
| 1989 |
Harbeson SL, Rich DH. Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements. Journal of Medicinal Chemistry. 32: 1378-92. PMID 2566685 DOI: 10.1021/Jm00126A039 |
0.461 |
|
| 1989 |
Miller KE, Rich DH. Molecular mechanics calculations of cyclosporin A analogues. Effect of chirality and degree of substitution on the side-chain conformations of (2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoic acid1 and related derivatives Journal of the American Chemical Society®. 111: 8351-8362. DOI: 10.1021/Ja00204A005 |
0.303 |
|
| 1988 |
Aebi JD, Guillaume D, Dunlap BE, Rich DH. Synthesis, conformation, and immunosuppressive activity of a conformationally restricted cyclosporine lactam analogue. Journal of Medicinal Chemistry. 31: 1805-15. PMID 3261799 DOI: 10.1021/Jm00117A022 |
0.313 |
|
| 1988 |
Harbeson SL, Rich DH. Inhibition of arginine aminopeptidase by bestatin and arphamenine analogues. Evidence for a new mode of binding to aminopeptidases. Biochemistry. 27: 7301-10. PMID 3207677 DOI: 10.1021/Bi00419A019 |
0.373 |
|
| 1988 |
Ocain TD, Rich DH. Synthesis of sulfur-containing analogues of bestatin. Inhibition of aminopeptidases by alpha-thiolbestatin analogues. Journal of Medicinal Chemistry. 31: 2193-9. PMID 3184126 DOI: 10.1021/Jm00119A022 |
0.417 |
|
| 1988 |
Maibaum J, Rich DH. Inhibition of porcine pepsin by two substrate analogues containing statine. The effect of histidine at the P2 subsite on the inhibition of aspartic proteinases. Journal of Medicinal Chemistry. 31: 625-9. PMID 3126296 DOI: 10.1021/Jm00398A022 |
0.408 |
|
| 1988 |
Maibaum J, Rich DH. A facile synthesis of statine and analogs by reduction of .beta.-keto esters derived from Boc-protected amino acids. HPLC analyses of their enantiomeric purity Journal of Organic Chemistry. 53: 869-873. DOI: 10.1021/Jo00239A035 |
0.377 |
|
| 1988 |
Yabe Y, Guillaume D, Rich DH. Irreversible inhibition of papain by epoxysuccinyl peptides. Carbon-13 NMR characterization of the site of alkylation Journal of the American Chemical Society. 110: 4043-4044. DOI: 10.1021/Ja00220A056 |
0.389 |
|
| 1988 |
Sun CQ, Rich DH. Asymmetric synthesis of threo β-hydroxy-α-N-methyl amino acids and MeBMT analogs via epoxides1. (Part 1) Tetrahedron Letters. 29: 5205-5208. DOI: 10.1016/S0040-4039(00)80717-0 |
0.336 |
|
| 1988 |
Shute RE, Kawai M, Rich DH. Conformationally constrained biologically active peptides: tentative identification of the antimitogenic bioactive confomer of the naturally occurring cyclic tetrapeptides Tetrahedron. 44: 685-695. DOI: 10.1016/S0040-4020(01)86109-3 |
0.396 |
|
| 1987 |
Pottorf RS, Rich DH, Engelke J, Suttie JW. Synthetic bovine prothrombin precursor 13-29 for studies of vitamin K dependent carboxylase. Journal of Medicinal Chemistry. 30: 445-8. PMID 3806626 DOI: 10.1021/Jm00385A034 |
0.423 |
|
| 1987 |
Shute RE, Dunlap B, Rich DH. Analogues of the cytostatic and antimitogenic agents chlamydocin and HC-toxin: synthesis and biological activity of chloromethyl ketone and diazomethyl ketone functionalized cyclic tetrapeptides. Journal of Medicinal Chemistry. 30: 71-8. PMID 3806605 DOI: 10.1021/Jm00384A013 |
0.402 |
|
| 1987 |
Holladay MW, Salituro FG, Rich DH. Synthetic and enzyme inhibition studies of pepstatin analogues containing hydroxyethylene and ketomethylene dipeptide isosteres. Journal of Medicinal Chemistry. 30: 374-83. PMID 3100803 DOI: 10.1021/Jm00385A020 |
0.485 |
|
| 1987 |
Salituro FG, Agarwal N, Hofmann T, Rich DH. Inhibition of aspartic proteinases by peptides containing lysine and ornithine side-chain analogues of statine. Journal of Medicinal Chemistry. 30: 286-95. PMID 3100801 DOI: 10.1021/Jm00385A010 |
0.447 |
|
| 1987 |
Shute RE, Rich DH. Synthesis and Evaluation of Novel Activated Mixed Carbonate Reagents for the Introduction of the 2-(Trimethylsilyl)ethoxycarbonyl(Teoc)-Protecting Group Synthesis. 1987: 346-349. DOI: 10.1055/S-1987-27939 |
0.34 |
|
| 1987 |
Shute RE, Rich DH. Prevention of diketopiperazine formation in peptide synthesis by a simultaneous deprotection–coupling procedure: entrapment of reactive nucleophilic species by in situ acylation Journal of the Chemical Society, Chemical Communications. 1155-1156. DOI: 10.1039/C39870001155 |
0.444 |
|
| 1987 |
Aebi JD, Dhaon MK, Rich DH. A short synthesis of enantiomerically pure (2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoic acid, the unusual C9 amino acid found in the immunosuppressive peptide cyclosporine The Journal of Organic Chemistry. 52: 2881-2886. DOI: 10.1021/Jo00389A041 |
0.36 |
|
| 1987 |
Shute RE, Rich DH. A novel double deprotection-peptide cyclisation procedure and its application to the synthesis of analogues of the cyclic tetrapeptide HC-toxin. Tetrahedron Letters. 28: 3419-3422. DOI: 10.1016/S0040-4039(00)96315-9 |
0.435 |
|
| 1987 |
Tung RD, Rich DH. Total synthesis of the unusual cyclosporine amino acid MeBMT Tetrahedron Letters. 28: 1139-1142. DOI: 10.1016/S0040-4039(00)95309-7 |
0.34 |
|
| 1987 |
SHUTE RE, RICH DH. ChemInform Abstract: A Novel Double Deprotection-Peptide Cyclization Procedure and Its Application to the Synthesis of Analogues of the Cyclic Tetrapeptide HC- Toxin. Cheminform. 18. DOI: 10.1002/CHIN.198752344 |
0.344 |
|
| 1986 |
Agarwal NS, Rich DH. Inhibition of cathepsin D by substrate analogues containing statine and by analogues of pepstatin. Journal of Medicinal Chemistry. 29: 2519-24. PMID 3783611 DOI: 10.1021/Jm00162A015 |
0.371 |
|
| 1986 |
Rich DH, Dhaon MK, Dunlap B, Miller SP. Synthesis and antimitogenic activities of four analogues of cyclosporin A modified in the 1-position. Journal of Medicinal Chemistry. 29: 978-84. PMID 3712387 DOI: 10.1002/Chin.198643299 |
0.342 |
|
| 1986 |
Tung RD, Dhaon MK, Rich DH. BOP-Cl mediated synthesis of the cyclosporine A 8-11 tetrapeptide fragment The Journal of Organic Chemistry. 51: 3350-3354. DOI: 10.1021/Jo00367A018 |
0.352 |
|
| 1986 |
Kawai M, Gardner JH, Rich DH. Stereoselective synthesis and absolute configuration of epoxyketones in chlamydocin and related cyclic tetrapeptides Tetrahedron Letters. 27: 1877-1880. DOI: 10.1016/S0040-4039(00)84399-3 |
0.379 |
|
| 1986 |
BOGER J, PAYNE LS, PERLOW DS, LOHR NS, POE M, BLAINE EH, ULM EH, SCHORN TW, LAMONT BI, LIN T, KAWAI M, RICH DH, VEBER DF. ChemInform Abstract: Renin Inhibitors. Syntheses of Subnanomolar, Competitive, Transition-State Analogue Inhibitors Containing a Novel Analogue of Statine. Chemischer Informationsdienst. 17. DOI: 10.1002/Chin.198613321 |
0.371 |
|
| 1985 |
Rich DH, Bernatowicz MS, Agarwal NS, Kawai M, Salituro FG, Schmidt PG. Inhibition of aspartic proteases by pepstatin and 3-methylstatine derivatives of pepstatin. Evidence for collected-substrate enzyme inhibition. Biochemistry. 24: 3165-73. PMID 3927973 DOI: 10.1021/Bi00334A014 |
0.451 |
|
| 1985 |
Schmidt PG, Holladay MW, Salituro FG, Rich DH. Identification of oxygen nucleophiles in tetrahedral intermediates: 2H and 18O induced isotope shifts in 13C NMR spectra of pepsin-bound peptide ketone pseudosubstrates. Biochemical and Biophysical Research Communications. 129: 597-602. PMID 3925948 DOI: 10.1016/0006-291X(85)90193-7 |
0.373 |
|
| 1985 |
Rich DH. Pepstatin-derived inhibitors of aspartic proteinases. A close look at an apparent transition-state analogue inhibitor. Journal of Medicinal Chemistry. 28: 263-73. PMID 3882966 DOI: 10.1021/Jm00381A001 |
0.342 |
|
| 1984 |
Dhaon MK, Lehrman SR, Rich DH, Engelke JA, Suttie JW. Derivatives of 2-methyl-1,4-naphthoquinone as substrates and inhibitors of the vitamin K dependent carboxylase. Journal of Medicinal Chemistry. 27: 1196-201. PMID 6332196 DOI: 10.1002/Chin.198506322 |
0.403 |
|
| 1984 |
Rich DH, Moon BJ, Harbeson S. Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes. Journal of Medicinal Chemistry. 27: 417-22. PMID 6142952 DOI: 10.1002/Chin.198438323 |
0.336 |
|
| 1983 |
Agarwal N, Rich DH. An improved cathepsin-D substrate and assay procedure. Analytical Biochemistry. 130: 158-65. PMID 6869796 DOI: 10.1016/0003-2697(83)90663-2 |
0.406 |
|
| 1983 |
Rich DH, Kawai M, Goodman HL, Suttie JW. Synthesis and biological properties of new hexapeptide substrates for vitamin K dependent carboxylase. Evidence for X-Pro cis/trans amide bond interconversions in prothrombin precursor fragment 18-23. Journal of Medicinal Chemistry. 26: 910-6. PMID 6854593 DOI: 10.1002/Chin.198408285 |
0.361 |
|
| 1983 |
Rich DH, Kawai M, Goodman HL, Engelke J, Suttie JW. Vitamin K-dependent carboxylase: synthesis of an inhibitor of the glutamyl binding site. Febs Letters. 152: 79-82. PMID 6840280 DOI: 10.1016/0014-5793(83)80486-4 |
0.417 |
|
| 1983 |
Rich DH, Terada Y, Kawai M. Statine and its derivatives. Conformational studies using nuclear magnetic resonance spectrometry and energy calculations. International Journal of Peptide and Protein Research. 22: 325-32. PMID 6629646 DOI: 10.1111/J.1399-3011.1983.Tb02098.X |
0.308 |
|
| 1983 |
Boger J, Lohr NS, Ulm EH, Poe M, Blaine EH, Fanelli GM, Lin TY, Payne LS, Schorn TW, LaMont BI, Vassil TC, Stabilito II, Veber DF, Rich DH, Bopari AS. Novel renin inhibitors containing the amino acid statine. Nature. 303: 81-4. PMID 6341856 DOI: 10.1038/303081A0 |
0.357 |
|
| 1983 |
Kawai M, Rich DH, Walton JD. The structure and conformation of HC-toxin. Biochemical and Biophysical Research Communications. 111: 398-403. PMID 6132602 DOI: 10.1016/0006-291X(83)90319-4 |
0.318 |
|
| 1983 |
Rich DH, Bernatowicz MS. Oxidation of statine-containing peptides to ketone analogs via novel peptide sulfonium ylides The Journal of Organic Chemistry. 48: 1999-2001. DOI: 10.1021/Jo00160A011 |
0.402 |
|
| 1983 |
Kawai M, Boparai AS, Bernatowicz MS, Rich DH. Synthesis of novel 3-methylstatine analogs. Assignment of absolute configuration The Journal of Organic Chemistry. 48: 1876-1879. DOI: 10.1021/Jo00159A017 |
0.397 |
|
| 1983 |
Kawai M, Jasensky RD, Rich DH. Conformational analysis by NMR spectrometry of the highly substituted cyclic tetrapeptides, chlamydocin and Ala4-chlamydocin. Evidence for a unique amide bond sequence in dimethyl sulfoxide-d6 Journal of the American Chemical Society. 105: 4456-4462. DOI: 10.1021/Ja00351A052 |
0.322 |
|
| 1983 |
Kawai M, Rich DH. Total Synthesis of the Cyclic Tetrapeptide, HC-Toxin Tetrahedron Letters. 24: 5309-5312. DOI: 10.1016/S0040-4039(00)87855-7 |
0.339 |
|
| 1983 |
Rich DH, Gardner JH. Synthesis of the Cytostatic Cyclic Tetrapeptide, Chlamydocin Tetrahedron Letters. 24: 5305-5308. DOI: 10.1016/S0040-4039(00)87854-5 |
0.386 |
|
| 1983 |
Holladay MW, Rich DH. Synthesis of hydroxyethylene and ketomethylene dipeptide isosteres Tetrahedron Letters. 24: 4401-4404. DOI: 10.1016/S0040-4039(00)85908-0 |
0.368 |
|
| 1983 |
Rich DH, Dhaon MK. Synthesis of a triprotected dl-β-carboxyaspartic acid (Asa) derivative suitable for the synthesis of Asa-containing peptides Tetrahedron Letters. 24: 1671-1674. DOI: 10.1016/S0040-4039(00)81741-4 |
0.435 |
|
| 1983 |
Rich DH, Singh J, Gardner JH. Synthesis of protected 2-amino-8-oxo-9,10-epoxydecanoic acid from 2-aminosuberic acid derivatives The Journal of Organic Chemistry. 48: 432-434. DOI: 10.1002/Chin.198335171 |
0.34 |
|
| 1983 |
RICH DH, DHAON MK. ChemInform Abstract: SYNTHESIS OF A TRIPROTECTED DL-β-CARBOXYASPARTIC ACID (ASA) DERIVATIVE SUITABLE FOR THE SYNTHESIS OF ASA-CONTAINING PEPTIDES Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198331316 |
0.335 |
|
| 1982 |
Rich DH, Boparai AS, Bernatowicz MS. Synthesis of a 3-oxo-4(S)-amino acid analog of pepstatin. A new inhibitor of carboxyl (acid) proteases. Biochemical and Biophysical Research Communications. 104: 1127-33. PMID 7041904 DOI: 10.1016/0006-291X(82)91367-5 |
0.411 |
|
| 1982 |
Rich DH, Bernatowicz MS. Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effect of structure in subsite P3 on inhibition of pepsin. Journal of Medicinal Chemistry. 25: 791-5. PMID 6809942 DOI: 10.1021/Jm00349A005 |
0.374 |
|
| 1982 |
James MN, Sielecki A, Salituro F, Rich DH, Hofmann T. Conformational flexibility in the active sites of aspartyl proteinases revealed by a pepstatin fragment binding to penicillopepsin. Proceedings of the National Academy of Sciences of the United States of America. 79: 6137-41. PMID 6755464 DOI: 10.1073/Pnas.79.20.6137 |
0.324 |
|
| 1982 |
Pastuszak J, Gardner JH, Singh J, Rich DH. Improved synthesis of [4-alanine]chlamydocin: cyclization studies of tetrapeptides containing five .alpha. substituents The Journal of Organic Chemistry. 47: 2982-2987. DOI: 10.1021/Jo00136A033 |
0.324 |
|
| 1981 |
Rich DH, Kawai M, Goodman HL, Suttie JW. Synthesis of two analogs of a cyclic hexapeptide with disulfide bridge corresponding to bovine prothrombin precursor sequence 18-23. Extent of carboxylation by vitamin K-dependent carboxylase International Journal of Peptide and Protein Research. 18: 41-51. PMID 7309367 DOI: 10.1002/Chin.198201307 |
0.422 |
|
| 1981 |
Rich DH, Russ Lehrman S, Kawai M, Goodman HL, Suttie JW. Synthesis of peptide analogues of prothrombin precursor sequence 5-9. Substrate specificity of vitamin K dependent carboxylase Journal of Medicinal Chemistry. 24: 706-711. PMID 7252980 DOI: 10.1002/Chin.198144297 |
0.425 |
|
| 1981 |
Rich DH, Jasensky RD, Mueller GC, Anderson KE. Analogues of the cytostatic cyclic tetrapeptide chlamydocin. Synthesis of N beta-(N-maleoylglycyl) and N beta-(tert-butyloxycarbonyl) derivatives of cyclo(Gly-L-Phe-D-Pro-L-Dap). Journal of Medicinal Chemistry. 24: 567-72. PMID 7241514 DOI: 10.1021/Jm00137A017 |
0.326 |
|
| 1981 |
Rich D, Moon BJ, Boparai A. Correction. Synthesis of (2S, 3 R)-3-Amino-2-hydroxy-5-methylhexanoic Acid Derivatives. Application to the Synthesis of Amastatin, and Inhibitor of Aminopeptidases The Journal of Organic Chemistry. 46: 5458-5458. DOI: 10.1021/Jo00339A602 |
0.405 |
|
| 1981 |
RICH DH, JASENSKY RD, MUELLER GC, ANDERSON KE. ChemInform Abstract: ANALOGS OF THE CYTOSTATIC CYCLIC TETRAPEPTIDE CHLAMYDOCIN. SYNTHESIS OF Nβ-(N-MALEOYLGLYCYL) AND Nβ-(TERT-BUTYLOXYCARBONYL) DERIVATIVES OF CYCLO(GLY-L-PHE-D-PRO-L-DAP) Chemischer Informationsdienst. 12. DOI: 10.1002/Chin.198144294 |
0.308 |
|
| 1980 |
Rich DH, Sun ET. Mechanism of inhibition of pepsin by pepstatin. Effect of inhibitor structure on dissociation constant and time-dependent inhibition. Biochemical Pharmacology. 29: 2205-12. PMID 6775634 DOI: 10.1016/0006-2952(80)90199-9 |
0.318 |
|
| 1980 |
Rich DH, Sun ET, Ulm E. Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effects of structure on inhibition of pepsin and renin. Journal of Medicinal Chemistry. 23: 27-33. PMID 6767029 DOI: 10.1002/Chin.198024285 |
0.419 |
|
| 1980 |
RICH DH, SUN ETO, ULM E. ChemInform Abstract: SYNTHESIS OF ANALOGS OF THE CARBOXYL PROTEASE INHIBITOR PEPSTATIN. EFFECT OF STRUCTURE ON INHIBITION OF PEPSIN AND RENIN Chemischer Informationsdienst. 11. DOI: 10.1002/CHIN.198024285 |
0.307 |
|
| 1979 |
Suttie JW, Lehrman SR, Geweke LO, Hageman JM, Rich DH. Vitamin K-dependent carboxylase: Requirements for carboxylation of soluble peptide substrates and substrate specificity Biochemical and Biophysical Research Communications. 86: 500-507. PMID 426799 DOI: 10.1016/0006-291X(79)91742-X |
0.406 |
|
| 1979 |
Rich DH, Jasensky RD. Stereoselective hydrogenation of dehydrophenylalanine in a cyclic tetrapeptide. Synthesis of [Ala4]-chlamydocin Journal of the American Chemical Society. 101: 5412-5414. DOI: 10.1021/Ja00512A050 |
0.334 |
|
| 1979 |
Rich DH, Singh J. The Carbodiimide Method Cheminform. 11: 241-261. DOI: 10.1016/B978-0-12-304201-9.50011-4 |
0.451 |
|
| 1978 |
Rich DH, Tam JP. Synthesis of dehydro amino acids and peptides by dehydrosulfenylation. Rate enhancement using sulfenic acid trapping agents. The Journal of Organic Chemistry. 42: 3815-20. PMID 925779 DOI: 10.1021/Jo00444A005 |
0.389 |
|
| 1978 |
Rich DH, Bhatnagar P, Mathiaparanam P, Grant JA, Tam JP. Synthesis of tentoxin and related dehydro cyclic tetrapeptides. The Journal of Organic Chemistry. 43: 296-302. PMID 621598 DOI: 10.1002/Chin.197822307 |
0.372 |
|
| 1978 |
Steele JA, Durbin RD, Uchytil TF, Rich DH. Tentoxin An uncompetitive inhibitor of lettuce chloroplast coupling factor 1 Bba - Bioenergetics. 501: 72-82. PMID 145874 DOI: 10.1016/0005-2728(78)90096-8 |
0.321 |
|
| 1978 |
Rich DH, Sun ET, Boparai AS. Synthesis of (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid derivatives. Analysis of diastereomeric purity The Journal of Organic Chemistry. 43: 3624-3626. DOI: 10.1021/Jo00412A053 |
0.349 |
|
| 1978 |
Rich DH, Bhatnagar PK, Jasensky RD, Steele JA, Uchytil TF, Durbin RD. Two conformations of the cyclic tetrapeptide, [dMeAla1]-tentoxin have different biological activities Bioorganic Chemistry. 7: 207-214. DOI: 10.1016/0045-2068(78)90049-4 |
0.309 |
|
| 1977 |
Rich DH, Sun E, Singh J. Synthesis of dideoxy-pepstatin. Mechanism of inhibition of porcine pepsin. Biochemical and Biophysical Research Communications. 74: 762-7. PMID 319803 DOI: 10.1016/0006-291X(77)90367-9 |
0.352 |
|
| 1977 |
Rich DH, Tam J. A method for introducing secondary amide bonds into strained cyclic peptides Tetrahedron Letters. 18: 749-750. DOI: 10.1016/S0040-4039(01)92744-3 |
0.345 |
|
| 1975 |
Rich DH, Gurwara SK. Preparation of a new o-nitrobenzyl resin for solid-phase synthesis of tert-butyloxycarbonyl-protected peptide acids. Journal of the American Chemical Society. 97: 1575-9. PMID 1133395 DOI: 10.1002/Chin.197522473 |
0.408 |
|
| 1975 |
Rich DH, Gesellchen PD, Tong D, Cheung A, Buckner CK. Alkylating derivatives of amino acids and peptides. Synthesis of N-maleoylamino acids, [1-(N-maleoylglycyl)cysteinyl]oxytocin. Effects on vasopressin-stimulated water loss from isolated toad bladder. Journal of Medicinal Chemistry. 18: 1004-10. PMID 808606 DOI: 10.1021/Jm00244A011 |
0.376 |
|
| 1975 |
RICH DH, TAM J, MATHIAPARANAM P, GRANT J. SelectiveN-Methylation of Dehydroamino Acids and Peptides Synthesis. 1975: 402-404. DOI: 10.1055/S-1975-23776 |
0.388 |
|
| 1975 |
Rich DH, Gurwara S. Removal of C-terminal peptide amides from a 3-nitro-4-aminomethyl-benzoyl amide resin by photolysis Tetrahedron Letters. 16: 301-304. DOI: 10.1016/S0040-4039(00)71848-X |
0.393 |
|
| 1975 |
Rich DH, Tam J. Synthesis of didehydropeptides from peptides containing 3-alkylthio-amino acid residues Tetrahedron Letters. 16: 211-212. DOI: 10.1016/S0040-4039(00)71824-7 |
0.446 |
|
| 1975 |
RICH DH, TAM JP. ChemInform Abstract: SYNTHESIS OF DIDEHYDROPEPTIDES FROM PEPTIDES CONTAINING 3-ALKYLTHIO-AMINO ACID RESIDUES Chemischer Informationsdienst. 6: no-no. DOI: 10.1002/chin.197516443 |
0.346 |
|
| 1975 |
RICH DH, TAM J, MATHIAPARANAM P, GRANT JA, MABUNI C. ChemInform Abstract: GENERAL SYNTHESIS OF DIDEHYDROAMINO-ACIDS AND PEPTIDES Chemischer Informationsdienst. 6: no-no. DOI: 10.1002/Chin.197506436 |
0.456 |
|
| 1974 |
Rich DH, Tam J, Mathiaparanam P, Grant JA, Mabuni C. General synthesis of didehydroamino-acids and peptides Journal of the Chemical Society, Chemical Communications. 897-898. DOI: 10.1039/C39740000897 |
0.421 |
|
| 1974 |
Rich DH, Mathiaparanam P. Synthesis of the cyclic tetrapeptide tentoxin. Effect of an N-methyldehydrophenylalanyl residue on conformation of linear tetrapeptides Tetrahedron Letters. 15: 4037-4040. DOI: 10.1016/S0040-4039(01)92077-5 |
0.351 |
|
| 1973 |
Rich DH, Gurwara SK. Removal of protected peptides from an ortho-nitrobenzyl resin by photolysis Journal of the Chemical Society, Chemical Communications. 610-611. DOI: 10.1039/C39730000610 |
0.394 |
|
| 1973 |
RICH DH, GURWARA SK. ChemInform Abstract: REMOVAL OF PROTECTED PEPTIDES FROM AN ORTHO-NITROBENZYL RESIN BY PHOTOLYSIS Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/Chin.197350429 |
0.407 |
|
| 1972 |
Vavrek RJ, Ferger MF, Allen GA, Rich DH, Blomquist AT, Du Vigneaud V. Synthesis of three oxytocin analogs related to (1-deaminopenicillamine)oxytocin possessing antioxytocic acitvity. Journal of Medicinal Chemistry. 15: 123-6. PMID 5008235 DOI: 10.1021/Jm00272A001 |
0.718 |
|
| 1972 |
VAVREK RJ, FERGER MF, ALLEN GA, RICH DH, BLOMQUIST AT, DU VIGNEAUD V. ChemInform Abstract: SYNTH. VON DREI OXYTOCIN-ANALOGA ANALOG DEM (1-DESAMINOPENICILLAMON)-OXYTOCIN Chemischer Informationsdienst. 3: no-no. DOI: 10.1002/Chin.197221442 |
0.604 |
|
| 1970 |
Johnson WS, Li T, Harbert CA, Bartlett WR, Herrin TR, Staskun B, Rich DH. Further developments in the nonenzymic biogenetic-like steroid synthesis. Journal of the American Chemical Society. 92: 4461-3. PMID 5428389 DOI: 10.1021/Ja00717A057 |
0.517 |
|
| 1970 |
Johnson WS, Brocksom TJ, Loew P, Rich DH, Werthemann L, Arnold RA, Li T, Faulkner DJ. Olefinic ketal Claisen reaction. Facile route to juvenile hormone Journal of the American Chemical Society. 92: 4463-4464. DOI: 10.1021/Ja00717A058 |
0.646 |
|
| 1970 |
JOHNSON WS, LI T, HARBERT CA, BARTLETT WR, HERRIN TR, STASKUN B, RICH DH. ChemInform Abstract: NICHTENZYMATISCHE, DER BIOGENESE ANALOGE STEROIDSYNTH. Chemischer Informationsdienst. Organische Chemie. 1: no-no. DOI: 10.1002/Chin.197042402 |
0.48 |
|
| 1970 |
JOHNSON WS, BROCKSOM TJ, LOEW P, RICH DH, WERTHEMANN L, ARNOLD RA, LI T, FAULKNER DJ. ChemInform Abstract: CLAISEN-RK. MIT OLEFINISCHEN KETALEN, EINE BEQUEME SYNTH. VON JUVENILHORMON Chemischer Informationsdienst. Organische Chemie. 1: no-no. DOI: 10.1002/Chin.197042392 |
0.685 |
|
| 1969 |
Blomquist AT, Rich DH, Carlson BA, Allen GA, Hruby VJ, Takashima H, Nangeroni LL, Glose P, Du Vigneaud V. Deuterated oxytocins: the synthesis and biological properties of a crystalline analog of deamino-oxytocin deuterated in the 5-asparagine position. Proceedings of the National Academy of Sciences of the United States of America. 64: 263-6. PMID 5263009 DOI: 10.1073/Pnas.64.1.263 |
0.721 |
|
| 1968 |
Blomquist AT, Rich DH, Hruby VJ, Nangeroni LL, Glose P, Du Vigneaud V. Deuterated oxytocins: the synthesis and biological properties of three crystalline analogs of deamino-oxytocin deuterated in the 1-beta-mercaptopropionic acid position. Proceedings of the National Academy of Sciences of the United States of America. 61: 688-92. PMID 5246000 DOI: 10.1073/Pnas.61.2.688 |
0.723 |
|
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