| Year |
Citation |
Score |
| 2008 |
Slep KC, Kercher MA, Wieland T, Chen CK, Simon MI, Sigler PB. Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation. Proceedings of the National Academy of Sciences of the United States of America. 105: 6243-8. PMID 18434540 DOI: 10.1073/Pnas.0801569105 |
0.413 |
|
| 2003 |
Lee S, Sowa ME, Watanabe YH, Sigler PB, Chiu W, Yoshida M, Tsai FT. The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state. Cell. 115: 229-40. PMID 14567920 DOI: 10.1016/S0092-8674(03)00807-9 |
0.343 |
|
| 2003 |
Chaudhry C, Farr GW, Todd MJ, Rye HS, Brunger AT, Adams PD, Horwich AL, Sigler PB. Role of the gamma-phosphate of ATP in triggering protein folding by GroEL-GroES: function, structure and energetics. The Embo Journal. 22: 4877-87. PMID 14517228 DOI: 10.1093/Emboj/Cdg477 |
0.761 |
|
| 2003 |
Juo ZS, Kassavetis GA, Wang J, Geiduschek EP, Sigler PB. Crystal structure of a transcription factor IIIB core interface ternary complex. Nature. 422: 534-9. PMID 12660736 DOI: 10.1038/nature01534 |
0.363 |
|
| 2002 |
Berkowitz B, Huang DB, Chen-Park FE, Sigler PB, Ghosh G. The x-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta -kappa B site. The Journal of Biological Chemistry. 277: 24694-700. PMID 11970948 DOI: 10.1074/Jbc.M200006200 |
0.66 |
|
| 2001 |
Korkhin Y, Littlefield O, Nelson PJ, Bell SD, Sigler PB. Preparation of components of archaeal transcription preinitiation complex. Methods in Enzymology. 334: 227-39. PMID 11398464 DOI: 10.1016/S0076-6879(01)34471-3 |
0.347 |
|
| 2001 |
Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB. Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A. Nature. 409: 1071-7. PMID 11234020 DOI: 10.1038/35059138 |
0.436 |
|
| 2000 |
Ma J, Sigler PB, Xu Z, Karplus M. A dynamic model for the allosteric mechanism of GroEL. Journal of Molecular Biology. 302: 303-13. PMID 10970735 DOI: 10.1006/Jmbi.2000.4014 |
0.5 |
|
| 2000 |
Tsai FT, Sigler PB. Structural basis of preinitiation complex assembly on human pol II promoters. The Embo Journal. 19: 25-36. PMID 10619841 DOI: 10.1093/Emboj/19.1.25 |
0.435 |
|
| 1999 |
Chen L, Sigler PB. The crystal structure of a GroEL/peptide complex: plasticity as a basis for substrate diversity. Cell. 99: 757-68. PMID 10619429 |
0.345 |
|
| 1999 |
Littlefield O, Korkhin Y, Sigler PB. The structural basis for the oriented assembly of a TBP/TFB/promoter complex. Proceedings of the National Academy of Sciences of the United States of America. 96: 13668-73. PMID 10570130 DOI: 10.1073/Pnas.96.24.13668 |
0.368 |
|
| 1999 |
Bell SD, Kosa PL, Sigler PB, Jackson SP. Orientation of the transcription preinitiation complex in archaea. Proceedings of the National Academy of Sciences of the United States of America. 96: 13662-7. PMID 10570129 DOI: 10.1073/Pnas.96.24.13662 |
0.331 |
|
| 1999 |
Schubert C, Hirsch JA, Gurevich VV, Engelman DM, Sigler PB, Fleming KG. Visual arrestin activity may be regulated by self-association. The Journal of Biological Chemistry. 274: 21186-90. PMID 10409673 DOI: 10.1074/Jbc.274.30.21186 |
0.673 |
|
| 1999 |
Gaudet R, Savage JR, McLaughlin JN, Willardson BM, Sigler PB. A molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G proteins by phosducin. Molecular Cell. 3: 649-60. PMID 10360181 DOI: 10.1016/S1097-2765(00)80358-5 |
0.575 |
|
| 1999 |
Meinke G, Sigler PB. DNA-binding mechanism of the monomeric orphan nuclear receptor NGFI-B. Nature Structural Biology. 6: 471-7. PMID 10331876 DOI: 10.1038/8276 |
0.418 |
|
| 1999 |
Hirsch JA, Schubert C, Gurevich VV, Sigler PB. The 2.8 A crystal structure of visual arrestin: a model for arrestin's regulation. Cell. 97: 257-69. PMID 10219246 DOI: 10.1016/S0092-8674(00)80735-7 |
0.676 |
|
| 1999 |
Vishnivetskiy SA, Paz CL, Schubert C, Hirsch JA, Sigler PB, Gurevich VV. How does arrestin respond to the phosphorylated state of rhodopsin? The Journal of Biological Chemistry. 274: 11451-4. PMID 10206946 DOI: 10.1074/Jbc.274.17.11451 |
0.701 |
|
| 1998 |
Xu Z, Sigler PB. GroEL/GroES: structure and function of a two-stroke folding machine. Journal of Structural Biology. 124: 129-41. PMID 10049801 DOI: 10.1006/Jsbi.1998.4060 |
0.553 |
|
| 1998 |
Sigler PB, Xu Z, Rye HS, Burston SG, Fenton WA, Horwich AL. Structure and function in GroEL-mediated protein folding. Annual Review of Biochemistry. 67: 581-608. PMID 9759498 DOI: 10.1146/Annurev.Biochem.67.1.581 |
0.509 |
|
| 1998 |
Williams SP, Sigler PB. Atomic structure of progesterone complexed with its receptor. Nature. 393: 392-6. PMID 9620806 DOI: 10.1038/30775 |
0.351 |
|
| 1998 |
Tanenbaum DM, Wang Y, Williams SP, Sigler PB. Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains. Proceedings of the National Academy of Sciences of the United States of America. 95: 5998-6003. PMID 9600906 DOI: 10.1073/Pnas.95.11.5998 |
0.459 |
|
| 1997 |
Cox JM, Hayward MM, Sanchez JF, Gegnas LD, van der Zee S, Dennis JH, Sigler PB, Schepartz A. Bidirectional binding of the TATA box binding protein to the TATA box. Proceedings of the National Academy of Sciences of the United States of America. 94: 13475-80. PMID 9391050 DOI: 10.1073/Pnas.94.25.13475 |
0.64 |
|
| 1997 |
Rye HS, Burston SG, Fenton WA, Beechem JM, Xu Z, Sigler PB, Horwich AL. Distinct actions of cis and trans ATP within the double ring of the chaperonin GroEL. Nature. 388: 792-8. PMID 9285593 DOI: 10.1038/42047 |
0.467 |
|
| 1997 |
Xu Z, Horwich AL, Sigler PB. The crystal structure of the asymmetric GroEL-GroES-(ADP)7 chaperonin complex. Nature. 388: 741-50. PMID 9285585 DOI: 10.1038/41944 |
0.577 |
|
| 1997 |
Bohm A, Gaudet R, Sigler PB. Structural aspects of heterotrimeric G-protein signaling. Current Opinion in Biotechnology. 8: 480-7. PMID 9265729 DOI: 10.1016/S0958-1669(97)80072-9 |
0.623 |
|
| 1997 |
Wang Y, Jiang Y, Meyering-Voss M, Sprinzl M, Sigler PB. Crystal structure of the EF-Tu.EF-Ts complex from Thermus thermophilus. Nature Structural Biology. 4: 650-6. PMID 9253415 DOI: 10.1038/Nsb0897-650 |
0.683 |
|
| 1997 |
Kosa PF, Ghosh G, DeDecker BS, Sigler PB. The 2.1-A crystal structure of an archaeal preinitiation complex: TATA-box-binding protein/transcription factor (II)B core/TATA-box. Proceedings of the National Academy of Sciences of the United States of America. 94: 6042-7. PMID 9177165 DOI: 10.1073/Pnas.94.12.6042 |
0.593 |
|
| 1997 |
Han SK, Yoon ET, Scott DL, Sigler PB, Cho W. Structural aspects of interfacial adsorption. A crystallographic and site-directed mutagenesis study of the phospholipase A2 from the venom of Agkistrodon piscivorus piscivorus. The Journal of Biological Chemistry. 272: 3573-82. PMID 9013608 DOI: 10.1074/Jbc.272.6.3573 |
0.357 |
|
| 1996 |
DeDecker BS, O'Brien R, Fleming PJ, Geiger JH, Jackson SP, Sigler PB. The crystal structure of a hyperthermophilic archaeal TATA-box binding protein. Journal of Molecular Biology. 264: 1072-84. PMID 9000631 DOI: 10.1006/jmbi.1996.0697 |
0.654 |
|
| 1996 |
Gaudet R, Bohm A, Sigler PB. Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin. Cell. 87: 577-88. PMID 8898209 DOI: 10.1016/S0092-8674(00)81376-8 |
0.675 |
|
| 1996 |
Jiang Y, Nock S, Nesper M, Sprinzl M, Sigler PB. Structure and importance of the dimerization domain in elongation factor Ts from Thermus thermophilus. Biochemistry. 35: 10269-78. PMID 8756682 DOI: 10.1021/Bi960918W |
0.665 |
|
| 1996 |
Geiger JH, Hahn S, Lee S, Sigler PB. Crystal structure of the yeast TFIIA/TBP/DNA complex. Science (New York, N.Y.). 272: 830-6. PMID 8629014 DOI: 10.1126/Science.272.5263.830 |
0.69 |
|
| 1996 |
Van Duyne GD, Ghosh G, Maas WK, Sigler PB. Structure of the oligomerization and L-arginine binding domain of the arginine repressor of Escherichia coli. Journal of Molecular Biology. 256: 377-91. PMID 8594204 DOI: 10.1006/jmbi.1996.0093 |
0.584 |
|
| 1996 |
Boisvert DC, Wang J, Otwinowski Z, Horwich AL, Sigler PB. The 2.4 A crystal structure of the bacterial chaperonin GroEL complexed with ATP gamma S. Nature Structural Biology. 3: 170-7. PMID 8564544 DOI: 10.1038/Nsb0296-170 |
0.378 |
|
| 1996 |
Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB. Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. Nature. 379: 369-74. PMID 8552196 DOI: 10.1038/379369A0 |
0.368 |
|
| 1996 |
Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB. The 2.0 A crystal structure of a heterotrimeric G protein. Nature. 379: 311-9. PMID 8552184 DOI: 10.1038/379311A0 |
0.42 |
|
| 1996 |
Geiger JH, Hahn S, Sigler PB. Structural analysis of the TBP/TFIIA/TATA complex Acta Crystallographica Section a Foundations of Crystallography. 52: C154-C154. DOI: 10.1107/S0108767396093087 |
0.589 |
|
| 1996 |
Sondeck J, Bohm A, Lambright DG, Skiba NP, Noel JP, Hamm HE, Sigler PB. Refined structures of heterotrimeric G protein complexes at high resolution Acta Crystallographica Section a Foundations of Crystallography. 52: C184-C185. DOI: 10.1107/S0108767396091921 |
0.527 |
|
| 1996 |
Jiang Y, Nock S, Nesper M, Sprinzl M, Sigler PB. Structure and importance of the dimerization domain in elongation factor Ts fromThermos thermophillus Acta Crystallographica Section a Foundations of Crystallography. 52: C187-C187. DOI: 10.1107/S0108767396091829 |
0.633 |
|
| 1996 |
Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB. Erratum: Crystal structure of a G-protein βγ dimer at 2.1 Å resolution Nature. 379: 847-847. DOI: 10.1038/379847A0 |
0.356 |
|
| 1995 |
Kwong PD, McDonald NQ, Sigler PB, Hendrickson WA. Structure of beta 2-bungarotoxin: potassium channel binding by Kunitz modules and targeted phospholipase action. Structure (London, England : 1993). 3: 1109-19. PMID 8590005 DOI: 10.1016/S0969-2126(01)00246-5 |
0.391 |
|
| 1995 |
Ferguson KM, Lemmon MA, Schlessinger J, Sigler PB. Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain. Cell. 83: 1037-46. PMID 8521504 DOI: 10.1016/0092-8674(95)90219-8 |
0.637 |
|
| 1995 |
Sigler PB, Horwich AL. Unliganded GroEL at 2.8 A: structure and functional implications. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 348: 113-9. PMID 7770481 DOI: 10.1098/Rstb.1995.0052 |
0.443 |
|
| 1995 |
Rastinejad F, Perlmann T, Evans RM, Sigler PB. Structural determinants of nuclear receptor assembly on DNA direct repeats. Nature. 375: 203-11. PMID 7746322 DOI: 10.1038/375203A0 |
0.411 |
|
| 1995 |
Gewirth DT, Sigler PB. The basis for half-site specificity explored through a non-cognate steroid receptor-DNA complex. Nature Structural Biology. 2: 386-94. PMID 7664096 DOI: 10.1038/Nsb0595-386 |
0.373 |
|
| 1995 |
Ferguson KM, Lemmon MA, Sigler PB, Schlessinger J. Scratching the surface with the PH domain. Nature Structural Biology. 2: 715-8. PMID 7552736 DOI: 10.1038/Nsb0995-715 |
0.612 |
|
| 1995 |
Ghosh G, van Duyne G, Ghosh S, Sigler PB. Structure of NF-kappa B p50 homodimer bound to a kappa B site. Nature. 373: 303-10. PMID 7530332 DOI: 10.1038/373303A0 |
0.561 |
|
| 1995 |
Lemmon MA, Ferguson KM, O'Brien R, Sigler PB, Schlessinger J. Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain. Proceedings of the National Academy of Sciences of the United States of America. 92: 10472-6. PMID 7479822 DOI: 10.1073/Pnas.92.23.10472 |
0.614 |
|
| 1994 |
Lambright DG, Noel JP, Hamm HE, Sigler PB. Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. Nature. 369: 621-8. PMID 8208289 DOI: 10.1038/369621A0 |
0.607 |
|
| 1994 |
Scott DL, Sigler PB. Structure and catalytic mechanism of secretory phospholipases A2. Advances in Protein Chemistry. 45: 53-88. PMID 8154374 DOI: 10.1016/S0065-3233(08)60638-5 |
0.372 |
|
| 1994 |
Shakked Z, Guzikevich-Guerstein G, Frolow F, Rabinovich D, Joachimiak A, Sigler PB. Determinants of repressor/operator recognition from the structure of the trp operator binding site. Nature. 368: 469-73. PMID 8133895 DOI: 10.1038/368469A0 |
0.464 |
|
| 1994 |
Sondek J, Lambright DG, Noel JP, Hamm HE, Sigler PB. GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4. Nature. 372: 276-9. PMID 7969474 DOI: 10.1038/372276A0 |
0.59 |
|
| 1994 |
Ferguson KM, Lemmon MA, Schlessinger J, Sigler PB. Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin. Cell. 79: 199-209. PMID 7954789 DOI: 10.1016/0092-8674(94)90190-2 |
0.602 |
|
| 1994 |
Braig K, Otwinowski Z, Hegde R, Boisvert DC, Joachimiak A, Horwich AL, Sigler PB. The crystal structure of the bacterial chaperonin GroEL at 2.8 A. Nature. 371: 578-86. PMID 7935790 DOI: 10.1038/371578A0 |
0.312 |
|
| 1993 |
Kim Y, Geiger JH, Hahn S, Sigler PB. Crystal structure of a yeast TBP/TATA-box complex. Nature. 365: 512-20. PMID 8413604 DOI: 10.1038/365512A0 |
0.674 |
|
| 1993 |
Noel JP, Hamm HE, Sigler PB. The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S. Nature. 366: 654-63. PMID 8259210 DOI: 10.1038/366654A0 |
0.652 |
|
| 1992 |
Hegde RS, Grossman SR, Laimins LA, Sigler PB. Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target. Nature. 359: 505-12. PMID 1328886 DOI: 10.1038/359505A0 |
0.406 |
|
| 1992 |
Pathak D, Sigler PB. Updating structure-function relationships in the bZip family of transcription factors. Current Opinion in Structural Biology 1992, 2:116...-123 Current Opinion in Structural Biology. 2: 116-123. DOI: 10.1016/0959-440X(92)90186-B |
0.421 |
|
| 1991 |
Marmorstein RQ, Sprinzl M, Sigler PB. An alkaline phosphatase protection assay to investigate trp repressor/operator interactions. Biochemistry. 30: 1141-8. PMID 1989682 |
0.547 |
|
| 1991 |
Luisi BF, Xu WX, Otwinowski Z, Freedman LP, Yamamoto KR, Sigler PB. Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature. 352: 497-505. PMID 1865905 DOI: 10.1038/352497A0 |
0.589 |
|
| 1991 |
Joachimiak A, Sigler PB. Crystallization of protein-DNA complexes. Methods in Enzymology. 208: 82-99. PMID 1779853 DOI: 10.1016/0076-6879(91)08009-7 |
0.376 |
|
| 1990 |
Luisi BF, Sigler PB. The stereochemistry and biochemistry of the trp repressor-operator complex. Biochimica Et Biophysica Acta. 1048: 113-26. PMID 2182120 DOI: 10.1016/0167-4781(90)90047-6 |
0.494 |
|
| 1989 |
Marmorstein RQ, Sigler PB. Stereochemical effects of L-tryptophan and its analogues on trp repressor's affinity for operator-DNA. The Journal of Biological Chemistry. 264: 9149-54. PMID 2656696 |
0.565 |
|
| 1988 |
Otwinowski Z, Schevitz RW, Zhang RG, Lawson CL, Joachimiak A, Marmorstein RQ, Luisi BF, Sigler PB. Crystal structure of trp repressor/operator complex at atomic resolution. Nature. 335: 321-9. PMID 3419502 DOI: 10.1038/335321a0 |
0.749 |
|
| 1988 |
Freedman LP, Yamamoto KR, Luisi BF, Sigler PB. More fingers in hand. Cell. 54: 444. PMID 3401923 DOI: 10.1016/0092-8674(88)90063-3 |
0.421 |
|
| 1988 |
Lawson CL, Zhang RG, Schevitz RW, Otwinowski Z, Joachimiak A, Sigler PB. Flexibility of the DNA-binding domains of trp repressor. Proteins. 3: 18-31. PMID 3375234 DOI: 10.1002/Prot.340030103 |
0.682 |
|
| 1988 |
Lawson CL, Sigler PB. The structure of trp pseudorepressor at 1.65A shows why indole propionate acts as a trp 'inducer'. Nature. 333: 869-71. PMID 3290685 DOI: 10.1038/333869A0 |
0.66 |
|
| 1988 |
Freedman LP, Luisi BF, Korszun ZR, Basavappa R, Sigler PB, Yamamoto KR. The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain. Nature. 334: 543-6. PMID 3043231 DOI: 10.1038/334543A0 |
0.593 |
|
| 1987 |
Zhang RG, Joachimiak A, Lawson CL, Schevitz RW, Otwinowski Z, Sigler PB. The crystal structure of trp aporepressor at 1.8 A shows how binding tryptophan enhances DNA affinity. Nature. 327: 591-7. PMID 3600756 DOI: 10.1038/327591A0 |
0.694 |
|
| 1987 |
Marmorstein RQ, Joachimiak A, Sprinzl M, Sigler PB. The structural basis for the interaction between L-tryptophan and the Escherichia coli trp aporepressor. The Journal of Biological Chemistry. 262: 4922-7. PMID 3549712 |
0.533 |
|
| 1987 |
Joachimiak A, Marmorstein RQ, Schevitz RW, Mandecki W, Fox JL, Sigler PB. Crystals of the trp repressor-operator complex suitable for X-ray diffraction analysis. The Journal of Biological Chemistry. 262: 4917-21. PMID 3549711 |
0.559 |
|
| 1987 |
Schevitz RW, Joachimiak A, Zhang R, Lawson CL, Marmorstein RQ, Otwinowski Z, Sigler PB. Thetrprepressor/operator system: the crystallography of ligand-activated genetic regulation Acta Crystallographica Section a Foundations of Crystallography. 43: C16-C16. DOI: 10.1107/S0108767387085118 |
0.653 |
|
| 1985 |
Renetseder R, Brunie S, Dijkstra BW, Drenth J, Sigler PB. A comparison of the crystal structures of phospholipase A2 from bovine pancreas and Crotalus atrox venom. The Journal of Biological Chemistry. 260: 11627-34. PMID 4044572 |
0.321 |
|
| 1985 |
Schevitz RW, Otwinowski Z, Joachimiak A, Lawson CL, Sigler PB. The three-dimensional structure of trp repressor. Nature. 317: 782-6. PMID 3903514 DOI: 10.1038/317782A0 |
0.697 |
|
| 1983 |
Joachimiak A, Schevitz RW, Kelley RL, Yanofsky C, Sigler PB. Functional inferences from crystals of Escherichia coli trp repressor. The Journal of Biological Chemistry. 258: 12641-3. PMID 6355089 |
0.31 |
|
| 1983 |
Joachimiak A, Kelley RL, Gunsalus RP, Yanofsky C, Sigler PB. Purification and characterization of trp aporepressor. Proceedings of the National Academy of Sciences of the United States of America. 80: 668-72. PMID 6338493 DOI: 10.1073/Pnas.80.3.668 |
0.375 |
|
| 1981 |
Keith C, Feldman DS, Deganello S, Glick J, Ward KB, Jones EO, Sigler PB. The 2.5 A crystal structure of a dimeric phospholipase A2 from the venom of Crotalus atrox. The Journal of Biological Chemistry. 256: 8602-7. PMID 7263673 |
0.71 |
|
| 1968 |
Sigler PB, Blow DM, Matthews BW, Henderson R. Structure of crystalline -chymotrypsin. II. A preliminary report including a hypothesis for the activation mechanism. Journal of Molecular Biology. 35: 143-64. PMID 5760561 DOI: 10.1016/S0022-2836(68)80043-9 |
0.695 |
|
| 1967 |
Matthews BW, Sigler PB, Henderson R, Blow DM. Three-dimensional structure of tosyl-alpha-chymotrypsin. Nature. 214: 652-6. PMID 6049071 DOI: 10.1038/214652A0 |
0.703 |
|
| 1966 |
Sigler PB, Jeffery BA, Matthews BW, Blow DM. An x-ray diffraction study of inhibited derivatives of alpha-chymotrypsin. Journal of Molecular Biology. 15: 175-92. PMID 5912039 DOI: 10.1016/S0022-2836(66)80219-X |
0.612 |
|
| 1965 |
Sigler PB, Blow DM. A means of promoting heavy-atom binding in protein crystals. Journal of Molecular Biology. 14: 640-4. PMID 5880874 |
0.6 |
|
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