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Douglas A. Mitchell, Ph.D. - Publications

Affiliations: 
2002-2002 Chemistry Merck Research Laboratories, Boston, MA, United States 
 2002-2006 Chemistry University of California, Berkeley, Berkeley, CA, United States 
 2006-2009 Chemistry University of California, San Diego, La Jolla, CA 
 2009- Chemistry University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
Area:
antibiotic resistance
Website:
http://www.chemistry.illinois.edu/faculty/Douglas_Mitchell.html
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111 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Lee AR, Carter RS, Imani AS, Dommaraju SR, Hudson GA, Mitchell DA, Freeman MF. Computationally guided exploration of borosin biosynthetic strategies. Biorxiv : the Preprint Server For Biology. PMID 38260703 DOI: 10.1101/2024.01.09.574750  0.46
2024 Fernandez HN, Kretsch AM, Kunakom S, Kadjo AE, Mitchell DA, Eustáquio AS. High-Yield Lasso Peptide Production in a Bacterial Host by Plasmid Copy Number Engineering. Acs Synthetic Biology. PMID 38194362 DOI: 10.1021/acssynbio.3c00597  0.429
2023 Woodard AM, Peccati F, Navo CD, Jiménez-Osés G, Mitchell DA. Benzylic Radical Stabilization Permits Ether Formation During Darobactin Biosynthesis. Biorxiv : the Preprint Server For Biology. PMID 38076856 DOI: 10.1101/2023.11.29.569256  0.314
2023 Saad H, Majer T, Bhattarai K, Lampe S, Nguyen DT, Kramer M, Straetener J, Brötz-Oesterhelt H, Mitchell DA, Gross H. Bioinformatics-guided discovery of biaryl-linked lasso peptides. Chemical Science. 14: 13176-13183. PMID 38023510 DOI: 10.1039/d3sc02380j  0.48
2023 Nguyen DT, Zhu L, Mitchell DA, van der Donk WA. Discovery of biaryl macrocyclic peptides with C-terminal β-amino-α-keto acid groups. Biorxiv : the Preprint Server For Biology. PMID 37965205 DOI: 10.1101/2023.10.30.564719  0.441
2023 Ren H, Huang C, Pan Y, Cui H, Dommaraju SR, Mitchell DA, Zhao H. Non-modular Fatty Acid Synthases Yield Unique Acylation in Ribosomal Peptides. Biorxiv : the Preprint Server For Biology. PMID 37961664 DOI: 10.1101/2023.10.25.564083  0.332
2023 Precord TW, Ramesh S, Dommaraju SR, Harris LA, Kille BL, Mitchell DA. Catalytic Site Proximity Profiling for Functional Unification of Sequence-Diverse Radical -Adenosylmethionine Enzymes. Acs Bio & Med Chem Au. 3: 240-251. PMID 37363077 DOI: 10.1021/acsbiomedchemau.2c00085  0.821
2023 Chadwick GL, Joiner AMN, Ramesh S, Mitchell DA, Nayak DD. McrD binds asymmetrically to methyl-coenzyme M reductase improving active-site accessibility during assembly. Proceedings of the National Academy of Sciences of the United States of America. 120: e2302815120. PMID 37307484 DOI: 10.1073/pnas.2302815120  0.787
2023 Ren H, Dommaraju SR, Huang C, Cui H, Pan Y, Nesic M, Zhu L, Sarlah D, Mitchell DA, Zhao H. Genome mining unveils a class of ribosomal peptides with two amino termini. Nature Communications. 14: 1624. PMID 36959188 DOI: 10.1038/s41467-023-37287-1  0.419
2023 Saad H, Majer T, Bhattarai K, Lampe S, Nguyen DT, Kramer M, Straetener J, Br Tz-Oesterhelt H, Mitchell DA, Gross H. Bioinformatics-Guided Discovery of Biaryl-Tailored Lasso Peptides. Biorxiv : the Preprint Server For Biology. PMID 36945544 DOI: 10.1101/2023.03.06.531328  0.475
2023 Ren H, Dommaraju SR, Huang C, Cui H, Pan Y, Nesic M, Zhu L, Sarlah D, Mitchell DA, Zhao H. Genome mining unveils a class of ribosomal peptides with two amino termini. Biorxiv : the Preprint Server For Biology. PMID 36945508 DOI: 10.1101/2023.03.08.531785  0.424
2023 Kretsch AM, Gadgil MG, DiCaprio AJ, Barrett SE, Kille BL, Si Y, Zhu L, Mitchell DA. Peptidase Activation by a Leader Peptide-Bound RiPP Recognition Element. Biochemistry. PMID 36734655 DOI: 10.1021/acs.biochem.2c00700  0.836
2022 Shelton KE, Mitchell DA. Bioinformatic prediction and experimental validation of RiPP recognition elements. Methods in Enzymology. 679: 191-233. PMID 36682862 DOI: 10.1016/bs.mie.2022.08.050  0.403
2022 Rice AJ, Pelton JM, Kramer NJ, Catlin DS, Nair SK, Pogorelov TV, Mitchell DA, Bowers AA. Enzymatic Pyridine Aromatization during Thiopeptide Biosynthesis. Journal of the American Chemical Society. PMID 36351243 DOI: 10.1021/jacs.2c07377  0.478
2022 Ayikpoe RS, Shi C, Battiste AJ, Eslami SM, Ramesh S, Simon MA, Bothwell IR, Lee H, Rice AJ, Ren H, Tian Q, Harris LA, Sarksian R, Zhu L, Frerk AM, ... ... Mitchell DA, et al. A scalable platform to discover antimicrobials of ribosomal origin. Nature Communications. 13: 6135. PMID 36253467 DOI: 10.1038/s41467-022-33890-w  0.827
2022 Ongpipattanakul C, Desormeaux EK, DiCaprio A, van der Donk WA, Mitchell DA, Nair SK. Mechanism of Action of Ribosomally Synthesized and Post-Translationally Modified Peptides. Chemical Reviews. PMID 36049139 DOI: 10.1021/acs.chemrev.2c00210  0.83
2022 Nguyen DT, Le TT, Rice AJ, Hudson GA, van der Donk WA, Mitchell DA. Accessing Diverse Pyridine-Based Macrocyclic Peptides by a Two-Site Recognition Pathway. Journal of the American Chemical Society. PMID 35713415 DOI: 10.1021/jacs.2c02824  0.822
2022 Mitchell D, Precord T, Hudson G, Mahanta N, Burkhart B, Gerlt J. Radical SAM Enzymes and the Unexplored Chemistry of RiPP Biosynthesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 35556269 DOI: 10.1096/fasebj.2022.36.S1.0I185  0.314
2021 Ramesh S, Guo X, DiCaprio AJ, De Lio AM, Harris LA, Kille BL, Pogorelov TV, Mitchell DA. Bioinformatics-Guided Expansion and Discovery of Graspetides. Acs Chemical Biology. 16: 2787-2797. PMID 34766760 DOI: 10.1021/acschembio.1c00672  0.805
2021 Precord TW, Mahanta N, Mitchell DA. Correction to "Reconstitution and Substrate Specificity of the Thioether-Forming Radical -Adenosylmethionine Enzyme in Freyrasin Biosynthesis". Acs Chemical Biology. PMID 34428027 DOI: 10.1021/acschembio.1c00536  0.708
2021 Liu A, Krushnamurthy PH, Subramanya KS, Mitchell DA, Mahanta N. Enzymatic thioamidation of peptide backbones. Methods in Enzymology. 656: 459-494. PMID 34325795 DOI: 10.1016/bs.mie.2021.04.010  0.827
2021 Hudson GA, Burkhart BJ, DiCaprio AJ, Schwalen CJ, Kille B, Pogorelov TV, Mitchell DA. Correction to "Bioinformatic Mapping of Radical -Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies New Cα, Cβ, and Cγ-Linked Thioether-Containing Peptides". Journal of the American Chemical Society. PMID 34197098 DOI: 10.1021/jacs.1c06285  0.815
2021 Si Y, Kretsch AM, Daigh LM, Burk MJ, Mitchell DA. Cell-Free Biosynthesis to Evaluate Lasso Peptide Formation and Enzyme-Substrate Tolerance. Journal of the American Chemical Society. PMID 33823110 DOI: 10.1021/jacs.1c01452  0.476
2021 Liu A, Si Y, Dong SH, Mahanta N, Penkala HN, Nair SK, Mitchell DA. Functional elucidation of TfuA in peptide backbone thioamidation. Nature Chemical Biology. PMID 33707784 DOI: 10.1038/s41589-021-00771-0  0.859
2020 Harris LA, Saint-Vincent PMB, Guo X, Hudson GA, DiCaprio AJ, Zhu L, Mitchell DA. Reactivity-Based Screening for Citrulline-Containing Natural Products Reveals a Family of Bacterial Peptidyl Arginine Deiminases. Acs Chemical Biology. PMID 33249828 DOI: 10.1021/acschembio.0c00685  0.858
2020 Georgiou MA, Dommaraju SR, Guo X, Mast DH, Mitchell DA. Bioinformatic and Reactivity-Based Discovery of Linaridins. Acs Chemical Biology. PMID 33170617 DOI: 10.1021/acschembio.0c00620  0.814
2020 Montalbán-López M, Scott TA, Ramesh S, Rahman IR, van Heel AJ, Viel JH, Bandarian V, Dittmann E, Genilloud O, Goto Y, Grande Burgos MJ, Hill C, Kim S, Koehnke J, Latham JA, ... ... Mitchell DA, et al. New developments in RiPP discovery, enzymology and engineering. Natural Product Reports. PMID 32935693 DOI: 10.1039/D0Np00027B  0.822
2020 Kloosterman AM, Shelton KE, van Wezel GP, Medema MH, Mitchell DA. RRE-Finder: a Genome-Mining Tool for Class-Independent RiPP Discovery. Msystems. 5. PMID 32873609 DOI: 10.1128/mSystems.00267-20  0.33
2020 Hudson GA, Hooper AR, DiCaprio AJ, Sarlah D, Mitchell DA. Structure Prediction and Synthesis of Pyridine-Based Macrocyclic Peptide Natural Products. Organic Letters. PMID 32845158 DOI: 10.1021/Acs.Orglett.0C02699  0.85
2020 Walker MC, Eslami SM, Hetrick KJ, Ackenhusen SE, Mitchell DA, van der Donk WA. Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family. Bmc Genomics. 21: 387. PMID 32493223 DOI: 10.1186/S12864-020-06785-7  0.586
2020 Nayak DD, Liu A, Agrawal N, Rodriguez-Carerro R, Dong SH, Mitchell DA, Nair SK, Metcalf WW. Functional interactions between posttranslationally modified amino acids of methyl-coenzyme M reductase in Methanosarcina acetivorans. Plos Biology. 18: e3000507. PMID 32092071 DOI: 10.1371/Journal.Pbio.3000507  0.763
2020 Sieber S, Grendelmeier SM, Harris LA, Mitchell DA, Gademann K. Microviridin 1777: A Toxic Chymotrypsin Inhibitor Discovered by a Metabologenomic Approach. Journal of Natural Products. PMID 31989826 DOI: 10.1021/Acs.Jnatprod.9B00986  0.501
2019 Melby JO, Li X, Mitchell DA. Correction to "Orchestration of Enzymatic Processing by Thiazole/Oxazole-Modified Microcin Dehydrogenases". Biochemistry. PMID 31855405 DOI: 10.1021/Acs.Biochem.9B01042  0.768
2019 Precord TW, Mahanta N, Mitchell DA. Reconstitution and substrate specificity of the thioether-forming radical S-adenosylmethionine enzyme in freyrasin biosynthesis. Acs Chemical Biology. PMID 31449382 DOI: 10.1021/Acschembio.9B00457  0.811
2019 Hudson GA, Mitchell DA. Corrigendum to "RiPP antibiotics: biosynthesis and engineering potential" [Curr Opin Microbiol 45 (2018) 61-69]. Current Opinion in Microbiology. PMID 31303539 DOI: 10.1016/J.Mib.2019.06.001  0.701
2019 Dong SH, Liu A, Mahanta N, Mitchell DA, Nair SK. Mechanistic Basis for Ribosomal Peptide Backbone Modifications. Acs Central Science. 5: 842-851. PMID 31139720 DOI: 10.1021/Acscentsci.9B00124  0.859
2019 Hudson GA, Burkhart BJ, DiCaprio AJ, Schwalen C, Kille B, Pogorelov TV, Mitchell DA. Bioinformatic mapping of radical SAM-dependent RiPPs identifies new Cα, Cβ, and Cγ-linked thioether-containing peptides. Journal of the American Chemical Society. PMID 31059252 DOI: 10.1021/Jacs.9B01519  0.822
2019 Mahanta N, Szantai-Kis DM, Petersson EJ, Mitchell DA. Biosynthesis and Chemical Applications of Thioamides. Acs Chemical Biology. PMID 30698414 DOI: 10.1021/Acschembio.8B01022  0.791
2018 DiCaprio AJ, Firouzbakht A, Hudson GA, Mitchell DA. Enzymatic Reconstitution and Biosynthetic Investigation of the Lasso Peptide Fusilassin. Journal of the American Chemical Society. PMID 30589265 DOI: 10.1021/Jacs.8B09928  0.859
2018 Hegemann JD, Schwalen CJ, Mitchell DA, van der Donk WA. Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin. Chemical Communications (Cambridge, England). PMID 30046789 DOI: 10.1039/C8Cc04411B  0.852
2018 Schwalen CJ, Hudson GA, Kille B, Mitchell DA. Bioinformatic expansion and discovery of thiopeptide antibiotics. Journal of the American Chemical Society. PMID 29983054 DOI: 10.1021/Jacs.8B03896  0.821
2018 Hudson GA, Mitchell DA. RiPP antibiotics: biosynthesis and engineering potential. Current Opinion in Microbiology. 45: 61-69. PMID 29533845 DOI: 10.1016/J.Mib.2018.02.010  0.796
2018 Mahanta N, Liu A, Dong S, Nair SK, Mitchell DA. Enzymatic reconstitution of ribosomal peptide backbone thioamidation. Proceedings of the National Academy of Sciences of the United States of America. PMID 29507203 DOI: 10.1073/Pnas.1722324115  0.853
2017 Schwalen CJ, Hudson GA, Kosol S, Mahanta N, Challis GL, Mitchell DA. In Vitro Biosynthetic Studies of Bottromycin Expand the Enzymatic Capabilities of the YcaO Superfamily. Journal of the American Chemical Society. 139: 18154-18157. PMID 29200283 DOI: 10.1021/Jacs.7B09899  0.854
2017 Zhang Z, Mahanta N, Hudson GA, Mitchell DA, van der Donk WA. Mechanism of a Class C Radical S-Adenosyl-l-methionine Thiazole Methyl Transferase. Journal of the American Chemical Society. PMID 29190095 DOI: 10.1021/Jacs.7B10203  0.783
2017 Cogan DP, Hudson GA, Zhang Z, Pogorelov TV, van der Donk WA, Mitchell DA, Nair SK. Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29158402 DOI: 10.1073/Pnas.1716035114  0.814
2017 Mahanta N, Hudson GA, Mitchell DA. Correction to Radical S-Adenosylmethionine Enzymes Involved in RiPP Biosynthesis. Biochemistry. PMID 29094593 DOI: 10.1021/Acs.Biochem.7B01056  0.785
2017 Mahanta N, Hudson GA, Mitchell DA. Radical SAM enzymes involved in RiPP biosynthesis. Biochemistry. PMID 28895719 DOI: 10.1021/Acs.Biochem.7B00771  0.827
2017 Nayak DD, Mahanta N, Mitchell DA, Metcalf WW. Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic Archaea. Elife. 6. PMID 28880150 DOI: 10.7554/Elife.29218  0.753
2017 Si T, Li B, Comi TJ, Wu Y, Hu P, Wu Y, Min Y, Mitchell DA, Zhao H, Sweedler JV. Profiling of microbial colonies for high-throughput engineering of multi-step enzymatic reactions via optically guided MALDI MS. Journal of the American Chemical Society. PMID 28792758 DOI: 10.1021/Jacs.7B04641  0.339
2017 Burkhart BJ, Kakkar N, Hudson GA, van der Donk WA, Mitchell DA. Chimeric Leader Peptides for the Generation of Non-Natural Hybrid RiPP Products. Acs Central Science. 3: 629-638. PMID 28691075 DOI: 10.1021/Acscentsci.7B00141  0.851
2017 Blin K, Wolf T, Chevrette MG, Lu X, Schwalen CJ, Kautsar SA, Suarez Duran HG, de Los Santos ELC, Kim HU, Nave M, Dickschat JS, Mitchell DA, Shelest E, Breitling R, Takano E, et al. antiSMASH 4.0-improvements in chemistry prediction and gene cluster boundary identification. Nucleic Acids Research. PMID 28460038 DOI: 10.1093/Nar/Gkx319  0.824
2017 Schwalen CJ, Feng X, Liu W, O-Dowd B, Ko TP, Shin CJ, Guo RT, Mitchell DA, Oldfield E. "Head-to-head" Prenyl Synthases in Some Pathogenic Bacteria. Chembiochem : a European Journal of Chemical Biology. PMID 28340291 DOI: 10.1002/Cbic.201700099  0.803
2017 Mahanta N, Zhang Z, Hudson GA, van der Donk WA, Mitchell DA. Reconstitution and substrate specificity of the radical SAM thiazole C-methyltransferase in thiomuracin biosynthesis. Journal of the American Chemical Society. PMID 28301141 DOI: 10.1021/Jacs.7B00693  0.832
2017 Burkhart BJ, Schwalen CJ, Mann G, Naismith JH, Mitchell DA. YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function. Chemical Reviews. PMID 28256131 DOI: 10.1021/Acs.Chemrev.6B00623  0.837
2017 Tietz JI, Schwalen CJ, Patel PS, Maxson T, Blair PM, Tai HC, Zakai UI, Mitchell DA. A new genome-mining tool redefines the lasso peptide biosynthetic landscape. Nature Chemical Biology. PMID 28244986 DOI: 10.1038/Nchembio.2319  0.849
2017 Nayak DD, Mahanta N, Mitchell DA, Metcalf WW. Author response: Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic Archaea Elife. DOI: 10.7554/Elife.29218.024  0.714
2016 Maxson T, Tietz JI, Hudson GA, Guo XR, Tai HC, Mitchell DA. Targeting reactive carbonyls for identifying natural products and their biosynthetic origins. Journal of the American Chemical Society. PMID 27797509 DOI: 10.1021/Jacs.6B06848  0.806
2016 Zhang Z, Hudson GA, Mahanta N, Tietz JI, van der Donk WA, Mitchell DA. Biosynthetic timing and substrate specificity for the thiopeptide thiomuracin. Journal of the American Chemical Society. PMID 27700071 DOI: 10.1021/Jacs.6B08987  0.842
2016 Deane CD, Burkhart BJ, Blair PM, Tietz JI, Lin A, Mitchell DA. In vitro biosynthesis and substrate tolerance of the plantazolicin family of natural products. Acs Chemical Biology. PMID 27248686 DOI: 10.1021/Acschembio.6B00369  0.862
2016 Molloy EM, Tietz JI, Blair PM, Mitchell DA. Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. Bioorganic & Medicinal Chemistry. PMID 27234886 DOI: 10.1016/J.Bmc.2016.05.021  0.393
2016 Molohon KJ, Blair PM, Park S, Doroghazi JR, Maxson T, Hershfield JR, Flatt KM, Schroeder NE, Ha T, Mitchell DA. Plantazolicin is an ultra-narrow spectrum antibiotic that targets the Bacillus anthracis membrane. Acs Infectious Diseases. 2: 207-220. PMID 27152321 DOI: 10.1021/Acsinfecdis.5B00115  0.337
2015 Hudson GA, Zhang Z, Tietz JI, Mitchell DA, van der Donk WA. In vitro biosynthesis of the core scaffold of the thiopeptide thiomuracin. Journal of the American Chemical Society. PMID 26675417 DOI: 10.1021/Jacs.5B10194  0.816
2015 Cox CL, Doroghazi JR, Mitchell DA. The genomic landscape of ribosomal peptides containing thiazole and oxazole heterocycles. Bmc Genomics. 16: 778. PMID 26462797 DOI: 10.1186/S12864-015-2008-0  0.578
2015 Tietz JI, Mitchell DA. Using Genomics for Natural Product Structure Elucidation. Current Topics in Medicinal Chemistry. PMID 26456468 DOI: 10.2174/1568026616666151012111439  0.368
2015 Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, ... ... Mitchell DA, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID 26284661 DOI: 10.1038/Nchembio.1890  0.45
2015 Molloy EM, Casjens SR, Cox CL, Maxson T, Ethridge NA, Margos G, Fingerle V, Mitchell DA. Identification of the minimal cytolytic unit for streptolysin S and an expansion of the toxin family. Bmc Microbiology. 15: 141. PMID 26204951 DOI: 10.1186/S12866-015-0464-Y  0.345
2015 Burkhart BJ, Hudson GA, Dunbar KL, Mitchell DA. A prevalent peptide-binding domain guides ribosomal natural product biosynthesis. Nature Chemical Biology. PMID 26167873 DOI: 10.1038/Nchembio.1856  0.853
2015 Dunbar KL, Tietz JI, Cox CL, Burkhart BJ, Mitchell DA. Identification of an Auxiliary Leader Peptide-Binding Protein Required for Azoline Formation in Ribosomal Natural Products. Journal of the American Chemical Society. 137: 7672-7. PMID 26024319 DOI: 10.1021/Jacs.5B04682  0.833
2015 Maxson T, Deane CD, Molloy EM, Cox CL, Markley AL, Lee SW, Mitchell DA. HIV protease inhibitors block streptolysin S production. Acs Chemical Biology. 10: 1217-26. PMID 25668590 DOI: 10.1021/Cb500843R  0.787
2015 Hao Y, Blair PM, Sharma A, Mitchell DA, Nair SK. Insights into methyltransferase specificity and bioactivity of derivatives of the antibiotic plantazolicin. Acs Chemical Biology. 10: 1209-16. PMID 25635336 DOI: 10.1021/Cb501042A  0.647
2015 Metelev M, Tietz JI, Melby JO, Blair PM, Zhu L, Livnat I, Severinov K, Mitchell DA. Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso Peptide from an understudied halophilic actinomycete. Chemistry & Biology. 22: 241-50. PMID 25601074 DOI: 10.1016/J.Chembiol.2014.11.017  0.815
2015 Tietz J, Zhu L, Mitchell D, Metelev M, Melby J, Blair P, Livnat I, Severinov K. Solution-state NMR structure of the lasso peptide streptomonomicin Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Mw3/Pdb  0.807
2014 Dunbar KL, Chekan JR, Cox CL, Burkhart BJ, Nair SK, Mitchell DA. Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis. Nature Chemical Biology. 10: 823-9. PMID 25129028 DOI: 10.1038/Nchembio.1608  0.806
2014 Zhang Q, Ortega M, Shi Y, Wang H, Melby JO, Tang W, Mitchell DA, van der Donk WA. Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS. Proceedings of the National Academy of Sciences of the United States of America. 111: 12031-6. PMID 25092299 DOI: 10.1073/Pnas.1406418111  0.82
2014 Cox CL, Tietz JI, Sokolowski K, Melby JO, Doroghazi JR, Mitchell DA. Nucleophilic 1,4-additions for natural product discovery. Acs Chemical Biology. 9: 2014-22. PMID 24937678 DOI: 10.1021/Cb500324N  0.808
2014 Hamel LD, Deschenes RJ, Mitchell DA. A fluorescence-based assay to monitor autopalmitoylation of zDHHC proteins applicable to high-throughput screening. Analytical Biochemistry. 460: 1-8. PMID 24878334 DOI: 10.1016/J.Ab.2014.05.013  0.647
2014 Mitchell DA, Hamel LD, Reddy KD, Farh L, Rettew LM, Sanchez PR, Deschenes RJ. Mutations in the X-linked intellectual disability gene, zDHHC9, alter autopalmitoylation activity by distinct mechanisms. The Journal of Biological Chemistry. 289: 18582-92. PMID 24811172 DOI: 10.1074/Jbc.M114.567420  0.642
2014 Melby JO, Li X, Mitchell DA. Orchestration of enzymatic processing by thiazole/oxazole-modified microcin dehydrogenases. Biochemistry. 53: 413-22. PMID 24364559 DOI: 10.1021/Bi401529Y  0.816
2014 Deane CD, Mitchell DA. Lessons learned from the transformation of natural product discovery to a genome-driven endeavor. Journal of Industrial Microbiology & Biotechnology. 41: 315-31. PMID 24142337 DOI: 10.1007/S10295-013-1361-8  0.38
2013 Sharma A, Blair PM, Mitchell DA. Synthesis of plantazolicin analogues enables dissection of ligand binding interactions of a highly selective methyltransferase. Organic Letters. 15: 5076-9. PMID 24063702 DOI: 10.1021/Ol402444A  0.515
2013 Lee J, Hao Y, Blair PM, Melby JO, Agarwal V, Burkhart BJ, Nair SK, Mitchell DA. Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 12954-9. PMID 23878226 DOI: 10.1073/Pnas.1306101110  0.806
2013 Deane CD, Melby JO, Molohon KJ, Susarrey AR, Mitchell DA. Engineering unnatural variants of plantazolicin through codon reprogramming. Acs Chemical Biology. 8: 1998-2008. PMID 23823732 DOI: 10.1021/Cb4003392  0.859
2013 Dunbar KL, Mitchell DA. Insights into the mechanism of peptide cyclodehydrations achieved through the chemoenzymatic generation of amide derivatives. Journal of the American Chemical Society. 135: 8692-701. PMID 23721104 DOI: 10.1021/Ja4029507  0.552
2013 Hu Y, Jia S, Ren F, Huang CH, Ko TP, Mitchell DA, Guo RT, Zheng Y. Crystallization and preliminary X-ray diffraction analysis of YisP protein from Bacillus subtilis subsp. subtilis strain 168. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 69: 77-9. PMID 23295493 DOI: 10.1107/S1744309112049330  0.31
2013 Dunbar KL, Mitchell DA. Revealing nature's synthetic potential through the study of ribosomal natural product biosynthesis. Acs Chemical Biology. 8: 473-87. PMID 23286465 DOI: 10.1021/Cb3005325  0.56
2013 Zhu W, Zhang Y, Sinko W, Hensler ME, Olson J, Molohon KJ, Lindert S, Cao R, Li K, Wang K, Wang Y, Liu YL, Sankovsky A, de Oliveira CA, Mitchell DA, et al. Antibacterial drug leads targeting isoprenoid biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 123-8. PMID 23248302 DOI: 10.1073/Pnas.1219899110  0.332
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Mitchell DA, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID 23165928 DOI: 10.1039/C2Np20085F  0.613
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Mitchell DA, et al. Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F) Natural Product Reports. 30: 1568-1568. DOI: 10.1039/C3Np90040A  0.606
2013 Dunbar KL, Mitchell DA. Correction to Revealing Nature’s Synthetic Potential through the Study of Ribosomal Natural Product Biosynthesis Acs Chemical Biology. 8: 1083-1083. DOI: 10.1021/Cb4002359  0.382
2012 Mitchell DA, Hamel LD, Ishizuka K, Mitchell G, Schaefer LM, Deschenes RJ. The Erf4 subunit of the yeast Ras palmitoyl acyltransferase is required for stability of the Acyl-Erf2 intermediate and palmitoyl transfer to a Ras2 substrate. The Journal of Biological Chemistry. 287: 34337-48. PMID 22904317 DOI: 10.1074/Jbc.M112.379297  0.64
2012 Dunbar KL, Melby JO, Mitchell DA. YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations. Nature Chemical Biology. 8: 569-75. PMID 22522320 DOI: 10.1038/Nchembio.944  0.845
2012 Melby JO, Dunbar KL, Trinh NQ, Mitchell DA. Selectivity, directionality, and promiscuity in peptide processing from a Bacillus sp. Al Hakam cyclodehydratase. Journal of the American Chemical Society. 134: 5309-16. PMID 22401305 DOI: 10.1021/Ja211675N  0.846
2011 Molohon KJ, Melby JO, Lee J, Evans BS, Dunbar KL, Bumpus SB, Kelleher NL, Mitchell DA. Structure determination and interception of biosynthetic intermediates for the plantazolicin class of highly discriminating antibiotics. Acs Chemical Biology. 6: 1307-13. PMID 21950656 DOI: 10.1021/Cb200339D  0.834
2011 Molloy EM, Cotter PD, Hill C, Mitchell DA, Ross RP. Streptolysin S-like virulence factors: the continuing sagA. Nature Reviews. Microbiology. 9: 670-81. PMID 21822292 DOI: 10.1038/Nrmicro2624  0.435
2011 Pei J, Mitchell DA, Dixon JE, Grishin NV. Expansion of type II CAAX proteases reveals evolutionary origin of γ-secretase subunit APH-1. Journal of Molecular Biology. 410: 18-26. PMID 21570408 DOI: 10.1016/J.Jmb.2011.04.066  0.533
2011 Melby JO, Nard NJ, Mitchell DA. Thiazole/oxazole-modified microcins: complex natural products from ribosomal templates. Current Opinion in Chemical Biology. 15: 369-78. PMID 21429787 DOI: 10.1016/J.Cbpa.2011.02.027  0.825
2011 Scholz R, Molohon KJ, Nachtigall J, Vater J, Markley AL, Süssmuth RD, Mitchell DA, Borriss R. Plantazolicin, a novel microcin B17/streptolysin S-like natural product from Bacillus amyloliquefaciens FZB42. Journal of Bacteriology. 193: 215-24. PMID 20971906 DOI: 10.1128/Jb.00784-10  0.804
2010 Gonzalez DJ, Lee SW, Hensler ME, Markley AL, Dahesh S, Mitchell DA, Bandeira N, Nizet V, Dixon JE, Dorrestein PC. Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum. The Journal of Biological Chemistry. 285: 28220-8. PMID 20581111 DOI: 10.1074/Jbc.M110.118554  0.786
2010 Haft DH, Basu MK, Mitchell DA. Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family. Bmc Biology. 8: 70. PMID 20500830 DOI: 10.1186/1741-7007-8-70  0.565
2009 Mitchell DA, Lee SW, Pence MA, Markley AL, Limm JD, Nizet V, Dixon JE. Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S. The Journal of Biological Chemistry. 284: 13004-12. PMID 19286651 DOI: 10.1074/Jbc.M900802200  0.853
2008 Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE. Discovery of a widely distributed toxin biosynthetic gene cluster. Proceedings of the National Academy of Sciences of the United States of America. 105: 5879-84. PMID 18375757 DOI: 10.1073/Pnas.0801338105  0.863
2007 Mitchell DA, Morton SU, Fernhoff NB, Marletta MA. Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 11609-14. PMID 17606900 DOI: 10.1073/Pnas.0704898104  0.778
2007 Mitchell DA, Michel T, Marletta MA. Effects of S-nitrosation of nitric oxide synthase Advances in Experimental Biology. 1: 151-179,456. DOI: 10.1016/S1872-2423(07)01007-1  0.41
2006 Mitchell DA, Morton SU, Marletta MA. Design and characterization of an active site selective caspase-3 transnitrosating agent. Acs Chemical Biology. 1: 659-65. PMID 17168570 DOI: 10.1021/Cb600393X  0.515
2006 Erwin PA, Mitchell DA, Sartoretto J, Marletta MA, Michel T. Subcellular targeting and differential S-nitrosylation of endothelial nitric-oxide synthase. The Journal of Biological Chemistry. 281: 151-7. PMID 16286475 DOI: 10.1074/Jbc.M510421200  0.514
2005 Mitchell DA, Marletta MA. Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine. Nature Chemical Biology. 1: 154-8. PMID 16408020 DOI: 10.1038/Nchembio720  0.559
2005 Mitchell DA, Erwin PA, Michel T, Marletta MA. S-Nitrosation and regulation of inducible nitric oxide synthase. Biochemistry. 44: 4636-47. PMID 15779890 DOI: 10.1021/Bi0474463  0.499
2002 Lazo JS, Nemoto K, Pestell KE, Cooley K, Southwick EC, Mitchell DA, Furey W, Gussio R, Zaharevitz DW, Joo B, Wipf P. Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors. Molecular Pharmacology. 61: 720-8. PMID 11901209 DOI: 10.1124/Mol.61.4.720  0.358
1995 Farh L, Mitchell DA, Deschenes RJ. Farnesylation and proteolysis are sequential, but distinct steps in the CaaX box modification pathway. Archives of Biochemistry and Biophysics. 318: 113-21. PMID 7726551 DOI: 10.1006/Abbi.1995.1211  0.711
1993 Mitchell DA, Marshall TK, Deschenes RJ. Vectors for the inducible overexpression of glutathione S-transferase fusion proteins in yeast Yeast. 9: 715-722. PMID 8368005 DOI: 10.1002/Yea.320090705  0.606
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