| Year |
Citation |
Score |
| 2020 |
Gao C, Liu Z, Hou H, Ding J, Chen X, Xie C, Song Z, Hu Z, Feng M, Mohamed HI, Xu S, Parkinson GN, Haider S, Wei D. BMPQ-1 binds selectively to (3+1) hybrid topologies in human telomeric G-quadruplex multimers. Nucleic Acids Research. PMID 33080032 DOI: 10.1093/nar/gkaa870 |
0.393 |
|
| 2020 |
Mori M, Gilardoni E, Regazzoni L, Pedretti A, Colombo D, Parkinson G, Asai A, Meneghetti F, Villa S, Gelain A. Towards the Inhibition of Protein-Protein Interactions (PPIs) in STAT3: Insights into a New Class of Benzothiadiazole Derivatives. Molecules (Basel, Switzerland). 25. PMID 32752073 DOI: 10.3390/Molecules25153509 |
0.305 |
|
| 2020 |
Zhang Y, El Omari K, Duman R, Liu S, Haider S, Wagner A, Parkinson GN, Wei D. Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths. Nucleic Acids Research. PMID 32453431 DOI: 10.1093/nar/gkaa439 |
0.35 |
|
| 2019 |
Parkinson GN, Collie GW. X-Ray Crystallographic Studies of G-Quadruplex Structures. Methods in Molecular Biology (Clifton, N.J.). 2035: 131-155. PMID 31444748 DOI: 10.1007/978-1-4939-9666-7_8 |
0.312 |
|
| 2018 |
Haider S, Li P, Khiali S, Munnur D, Ramanathan A, Parkinson GN. Holliday Junctions Formed from Human Telomeric DNA. Journal of the American Chemical Society. PMID 30376323 DOI: 10.1021/Jacs.8B08699 |
0.375 |
|
| 2018 |
Shih PC, Yang Y, Parkinson GN, Wilderspin A, Wells G. A high-throughput fluorescence polarization assay for discovering inhibitors targeting the DNA-binding domain of signal transducer and activator of transcription 3 (STAT3). Oncotarget. 9: 32690-32701. PMID 30220975 DOI: 10.18632/Oncotarget.26013 |
0.708 |
|
| 2018 |
Gunaratnam M, Collie GW, Reszka AP, Todd AK, Parkinson GN, Neidle S. A naphthalene diimide G-quadruplex ligand inhibits cell growth and down-regulates BCL-2 expression in an imatinib-resistant gastrointestinal cancer cell line. Bioorganic & Medicinal Chemistry. PMID 29724653 DOI: 10.1016/J.Bmc.2018.04.050 |
0.448 |
|
| 2017 |
Simone R, Balendra R, Moens TG, Preza E, Wilson KM, Heslegrave A, Woodling NS, Niccoli T, Gilbert-Jaramillo J, Abdelkarim S, Clayton EL, Clarke M, Konrad MT, Nicoll AJ, Mitchell JS, ... ... Parkinson G, et al. G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo. Embo Molecular Medicine. PMID 29113975 DOI: 10.15252/Emmm.201707850 |
0.558 |
|
| 2017 |
Noureini SK, Esmaeili H, Abachi F, Khiali S, Islam B, Kuta M, Saboury AA, Hoffmann M, Sponer J, Parkinson G, Haider S. Selectivity of major isoquinoline alkaloids from Chelidomium majus towards telomeric G-quadruplex: A study using a modified transition-FRET (t-FRET) assay. Biochimica Et Biophysica Acta. PMID 28479277 DOI: 10.1016/J.Bbagen.2017.05.002 |
0.404 |
|
| 2016 |
Russo Krauss I, Ramaswamy S, Neidle S, Haider S, Parkinson GN. Structural Insights into the Quadruplex-Duplex 3' Interface formed from a Telomeric Repeat: A Potential Molecular Target. Journal of the American Chemical Society. PMID 26730610 DOI: 10.1021/Jacs.5B10492 |
0.624 |
|
| 2016 |
Balendra R, Mizielinska S, Moens T, Niccoli T, Ridler C, Simone R, Woodling N, Parkinson G, Neidle S, Patani R, Partridge L, Isaacs A. Molecular mechanisms and therapeutic strategies in amyotrophic lateral sclerosis caused by C9orf72 mutations The Lancet. 387. DOI: 10.1016/S0140-6736(16)00400-1 |
0.471 |
|
| 2015 |
Simone R, Fratta P, Neidle S, Parkinson GN, Isaacs AM. G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome. Febs Letters. 589: 1653-68. PMID 25979174 DOI: 10.1016/J.Febslet.2015.05.003 |
0.511 |
|
| 2014 |
Russo Krauss I, Parkinson GN, Merlino A, Mattia CA, Randazzo A, Novellino E, Mazzarella L, Sica F. A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex. Acta Crystallographica. Section D, Biological Crystallography. 70: 362-70. PMID 24531470 DOI: 10.1107/S1399004713028095 |
0.34 |
|
| 2013 |
Wei D, Todd AK, Zloh M, Gunaratnam M, Parkinson GN, Neidle S. Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplex Journal of the American Chemical Society. 135: 19319-19329. PMID 24295054 DOI: 10.1021/Ja4101358 |
0.527 |
|
| 2013 |
Nkansah E, Shah R, Collie GW, Parkinson GN, Palmer J, Rahman KM, Bui TT, Drake AF, Husby J, Neidle S, Zinzalla G, Thurston DE, Wilderspin AF. Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography Febs Letters. 587: 833-839. PMID 23434585 DOI: 10.1016/J.Febslet.2013.01.065 |
0.493 |
|
| 2012 |
Fratta P, Mizielinska S, Nicoll AJ, Zloh M, Fisher EM, Parkinson G, Isaacs AM. C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes. Scientific Reports. 2: 1016. PMID 23264878 DOI: 10.1038/Srep01016 |
0.425 |
|
| 2012 |
Wei D, Parkinson GN, Reszka AP, Neidle S. Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation Nucleic Acids Research. 40: 4691-4700. PMID 22287624 DOI: 10.1093/Nar/Gks023 |
0.501 |
|
| 2012 |
Collie GW, Promontorio R, Hampel SM, Micco M, Neidle S, Parkinson GN. Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands Journal of the American Chemical Society. 134: 2723-2731. PMID 22280460 DOI: 10.1021/Ja2102423 |
0.615 |
|
| 2012 |
Campbell NH, Karim NHA, Parkinson GN, Gunaratnam M, Petrucci V, Todd AK, Vilar R, Neidle S. Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes Journal of Medicinal Chemistry. 55: 209-222. PMID 22112241 DOI: 10.1021/Jm201140V |
0.544 |
|
| 2011 |
Collie GW, Parkinson GN. The application of DNA and RNA G-quadruplexes to therapeutic medicines. Chemical Society Reviews. 40: 5867-92. PMID 21789296 DOI: 10.1039/c1cs15067g |
0.406 |
|
| 2011 |
Haider SM, Neidle S, Parkinson GN. A structural analysis of G-quadruplex/ligand interactions Biochimie. 93: 1239-1251. PMID 21635933 DOI: 10.1016/J.Biochi.2011.05.012 |
0.56 |
|
| 2011 |
Collie GW, Sparapani S, Parkinson GN, Neidle S. Structural basis of telomeric RNA quadruplex-acridine ligand recognition Journal of the American Chemical Society. 133: 2721-2728. PMID 21291211 DOI: 10.1021/Ja109767Y |
0.589 |
|
| 2010 |
Collie GW, Parkinson GN, Neidle S, Rosu F, De Pauw E, Gabelica V. Electrospray mass spectrometry of telomeric RNA (TERRA) reveals the formation of stable multimeric G-quadruplex structures. Journal of the American Chemical Society. 132: 9328-34. PMID 20565109 DOI: 10.1021/Ja100345Z |
0.542 |
|
| 2010 |
Collie GW, Haider SM, Neidle S, Parkinson GN. A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex Nucleic Acids Research. 38: 5569-5580. PMID 20413582 DOI: 10.1093/Nar/Gkq259 |
0.585 |
|
| 2010 |
Gunaratnam M, Collie G, Reszka A, Todd A, Parkinson G, Fletcher J, Neidle S. Abstract 3679: Targeting drug-resistant GIST cells with a quadruplex-binding small molecule Cancer Research. 70: 3679-3679. DOI: 10.1158/1538-7445.Am10-3679 |
0.574 |
|
| 2009 |
Collie G, Reszka AP, Haider SM, Gabelica V, Parkinson GN, Neidle S. Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes Chemical Communications. 7482-7484. PMID 20024253 DOI: 10.1039/B901889A |
0.544 |
|
| 2009 |
Campbell NH, Patel M, Tofa AB, Ghosh R, Parkinson GN, Neidle S. Selectivity in ligand recognition of G-quadruplex loops. Biochemistry. 48: 1675-80. PMID 19173611 DOI: 10.1021/Bi802233V |
0.523 |
|
| 2009 |
Collie G, Neidle S, Parkinson G. Targeting telomeric RNA quadruplexes Acta Crystallographica Section a Foundations of Crystallography. 65: s151-s151. DOI: 10.1107/S0108767309096950 |
0.488 |
|
| 2008 |
Drewe WC, Nanjunda R, Gunaratnam M, Beltran M, Parkinson GN, Reszka AP, Wilson WD, Neidle S. Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs. Journal of Medicinal Chemistry. 51: 7751-67. PMID 19053833 DOI: 10.1021/jm801245v |
0.566 |
|
| 2008 |
Antonow D, Barata T, Jenkins TC, Parkinson GN, Howard PW, Thurston DE, Zloh M. Solution structure of a 2:1 C2-(2-naphthyl) pyrrolo[2,1-c][1,4]benzodiazepine DNA adduct: molecular basis for unexpectedly high DNA helix stabilization. Biochemistry. 47: 11818-29. PMID 18925745 DOI: 10.1021/Bi801225Q |
0.319 |
|
| 2008 |
Parkinson GN, Cuenca F, Neidle S. Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes. Journal of Molecular Biology. 381: 1145-56. PMID 18619463 DOI: 10.1016/J.Jmb.2008.06.022 |
0.58 |
|
| 2008 |
Campbell NH, Parkinson GN, Reszka AP, Neidle S. Structural basis of DNA quadruplex recognition by an acridine drug Journal of the American Chemical Society. 130: 6722-6724. PMID 18457389 DOI: 10.1021/Ja8016973 |
0.569 |
|
| 2008 |
Neidle S, Parkinson GN. Quadruplex DNA crystal structures and drug design Biochimie. 90: 1184-1196. PMID 18395014 DOI: 10.1016/J.Biochi.2008.03.003 |
0.58 |
|
| 2008 |
Haider S, Parkinson GN, Neidle S. Molecular dynamics and principal components analysis of human telomeric quadruplex multimers Biophysical Journal. 95: 296-311. PMID 18375510 DOI: 10.1529/Biophysj.107.120501 |
0.597 |
|
| 2008 |
Zagotto G, Sissi C, Moro S, Dal Ben D, Parkinson GN, Fox KR, Neidle S, Palumbo M. Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives. Bioorganic & Medicinal Chemistry. 16: 354-61. PMID 17936629 DOI: 10.1016/J.Bmc.2007.09.040 |
0.544 |
|
| 2008 |
Antonow D, Barata T, Jenkins T, Parkinson G, Howard P, Thurston D, Zloh M. SOLUTION STRUCTURE OF THE BIS-C2-2-NAPHTHYLPYRROLO[2,1-c][1,4]BENZODIAZEPINE (DA046) DNA ADDUCT: THE MOLECULAR BASIS FOR DNA HELIX STABILIZATION. Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr15613 |
0.407 |
|
| 2007 |
Campbell NH, Parkinson GN. Crystallographic studies of quadruplex nucleic acids. Methods (San Diego, Calif.). 43: 252-63. PMID 17967696 DOI: 10.1016/j.ymeth.2007.08.005 |
0.436 |
|
| 2007 |
Todd AK, Haider SM, Parkinson GN, Neidle S. Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter Nucleic Acids Research. 35: 5799-5808. PMID 17720713 DOI: 10.1093/Nar/Gkm609 |
0.523 |
|
| 2007 |
Lee MP, Parkinson GN, Hazel P, Neidle S. Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel. Journal of the American Chemical Society. 129: 10106-7. PMID 17661470 DOI: 10.1021/Ja0740869 |
0.427 |
|
| 2007 |
Parkinson GN, Ghosh R, Neidle S. Structural basis for binding of porphyrin to human telomeres Biochemistry. 46: 2390-2397. PMID 17274602 DOI: 10.1021/Bi062244N |
0.62 |
|
| 2006 |
Burge S, Parkinson GN, Hazel P, Todd AK, Neidle S. Quadruplex DNA: Sequence, topology and structure Nucleic Acids Research. 34: 5402-5415. PMID 17012276 DOI: 10.1093/Nar/Gkl655 |
0.59 |
|
| 2006 |
Hazel P, Parkinson GN, Neidle S. Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures Nucleic Acids Research. 34: 2117-2127. PMID 16641317 DOI: 10.1093/Nar/Gkl182 |
0.457 |
|
| 2006 |
Hazel P, Parkinson GN, Neidle S. Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex Journal of the American Chemical Society. 128: 5480-5487. PMID 16620121 DOI: 10.1021/Ja058577+ |
0.557 |
|
| 2006 |
Campbell NH, Evans DA, Lee MP, Parkinson GN, Neidle S. Targeting the DNA minor groove with fused ring dicationic compounds: comparison of in silico screening and a high-resolution crystal structure. Bioorganic & Medicinal Chemistry Letters. 16: 15-9. PMID 16263285 DOI: 10.1016/J.Bmcl.2005.10.036 |
0.553 |
|
| 2005 |
Miao Y, Lee MP, Parkinson GN, Batista-Parra A, Ismail MA, Neidle S, Boykin DW, Wilson WD. Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove. Biochemistry. 44: 14701-8. PMID 16274217 DOI: 10.1021/bi051791q |
0.455 |
|
| 2005 |
Rankin S, Reszka AP, Huppert J, Zloh M, Parkinson GN, Todd AK, Ladame S, Balasubramanian S, Neidle S. Putative DNA quadruplex formation within the human c-kit oncogene. Journal of the American Chemical Society. 127: 10584-9. PMID 16045346 DOI: 10.1021/Ja050823U |
0.506 |
|
| 2004 |
Cáceres C, Wright G, Gouyette C, Parkinson G, Subirana JA. A thymine tetrad in d(TGGGGT) quadruplexes stabilized with Tl+/Na+ ions. Nucleic Acids Research. 32: 1097-102. PMID 14960719 DOI: 10.1093/Nar/Gkh269 |
0.397 |
|
| 2003 |
Johansson E, Parkinson GN, Denny WA, Neidle S. Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form Journal of Medicinal Chemistry. 46: 4009-4020. PMID 12954054 DOI: 10.1021/Jm030843B |
0.436 |
|
| 2003 |
Neidle S, Parkinson GN. The structure of telomeric DNA Current Opinion in Structural Biology. 13: 275-283. PMID 12831878 DOI: 10.1016/S0959-440X(03)00072-1 |
0.549 |
|
| 2003 |
Haider SM, Parkinson GN, Neidle S. Structure of a G-quadruplex-ligand complex Journal of Molecular Biology. 326: 117-125. PMID 12547195 DOI: 10.1016/S0022-2836(02)01354-2 |
0.603 |
|
| 2002 |
Benoff B, Yang H, Lawson CL, Parkinson G, Liu J, Blatter E, Ebright YW, Berman HM, Ebright RH. Structural basis of transcription activation: The CAP-αCTD-DNA complex Science. 297: 1562-1566. PMID 12202833 DOI: 10.1126/Science.1076376 |
0.446 |
|
| 2002 |
Neidle S, Parkinson G. Telomere maintenance as a target for anticancer drug discovery Nature Reviews Drug Discovery. 1: 383-393. PMID 12120414 DOI: 10.1038/Nrd793 |
0.486 |
|
| 2002 |
Haider S, Parkinson GN, Neidle S. Crystal structure of the potassium form of an Oxytricha nova G-quadruplex Journal of Molecular Biology. 320: 189-200. PMID 12079378 DOI: 10.1016/S0022-2836(02)00428-X |
0.511 |
|
| 2002 |
Parkinson GN, Lee MPH, Neidle S. Crystal structure of parallel quadruplexes from human telomeric DNA Nature. 417: 876-880. PMID 12050675 DOI: 10.1038/Nature755 |
0.573 |
|
| 2001 |
Mann J, Baron A, Opoku-Boahen Y, Johansson E, Parkinson G, Kelland LR, Neidle S. A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity Journal of Medicinal Chemistry. 44: 138-144. PMID 11170623 DOI: 10.1021/Jm000297B |
0.524 |
|
| 2001 |
Convery M, Dennis C, Rowsell S, Kortemme T, Schueler-Furman O, Watters A, Engel A, Fiser A, Parkinson G, Copley R, Gilardi G, Newman R, Sinning I, Flitsch SL, Lowden PA, et al. Paper alert: Structural biology Current Opinion in Structural Biology. 11: 501-510. DOI: 10.1016/S0959-440X(00)00240-2 |
0.312 |
|
| 2001 |
Convery M, Dennis C, Rowsell S, Kortemme T, Nauli S, Watters A, Bullock AN, Engel A, Melo F, Copley R, Parkinson G, Gilardi G, Newman R, Flitsch SL, Lowden PA, et al. Structural Biology Current Opinion in Structural Biology. 11: 1-7. DOI: 10.1016/S0959-440X(00)00161-5 |
0.342 |
|
| 2000 |
Johansson E, Parkinson G, Neidle S. A new crystal form for the dodecamer C-G-C-G-A-A-T-T-C-G-C-G: symmetry effects on sequence-dependent DNA structure. Journal of Molecular Biology. 300: 551-61. PMID 10884351 DOI: 10.1006/Jmbi.2000.3907 |
0.567 |
|
| 1997 |
Parkinson G, Wilson C, Gunasekera A, Ebright YW, Ebright RE, Berman HM. Structure of the CAP-DNA complex at 2.5 angstroms resolution: a complete picture of the protein-DNA interface. Journal of Molecular Biology. 260: 395-408. DOI: 10.2210/Pdb1J59/Pdb |
0.455 |
|
| 1996 |
Parkinson G, Vojtechovsky J, Clowney L, Brünger AT, Berman HM. New parameters for the refinement of nucleic acid-containing structures. Acta Crystallographica. Section D, Biological Crystallography. 52: 57-64. PMID 15299726 DOI: 10.1107/S0907444995011115 |
0.433 |
|
| 1996 |
Parkinson G, Gunasekera A, Vojtechovsky J, Zhang X, Kunkel TA, Berman H, Ebright RH. Aromatic hydrogen bond in sequence-specific protein DNA recognition Nature Structural Biology. 3: 837-841. PMID 8836098 DOI: 10.1038/Nsb1096-837 |
0.31 |
|
| 1996 |
Parkinson G, Wilson C, Gunasekera A, Ebright YW, Ebright RE, Berman HM. Structure of the CAP-DNA complex at 2.5 Å resolution: A complete picture of the protein-DNA interface Journal of Molecular Biology. 260: 395-408. PMID 8757802 DOI: 10.1006/Jmbi.1996.0409 |
0.457 |
|
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