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Matthew J. Siegel, Ph.D. - Publications

Affiliations: 
2007 Stanford University, Palo Alto, CA 
Area:
Bioorganic and Biophysical Chemistry
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22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Finn PD, Rodriguez D, Kohler J, Jiang Z, Wan S, Blanco E, King AJ, Chen T, Bell N, Dragoli D, Jacobs JW, Jain R, Leadbetter M, Siegel M, Carreras CW, et al. Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 30605011 DOI: 10.1152/Ajpgi.00300.2018  0.346
2018 King AJ, Siegel M, He Y, Nie B, Wang J, Koo-McCoy S, Minassian NA, Jafri Q, Pan D, Kohler J, Kumaraswamy P, Kozuka K, Lewis JG, Dragoli D, Rosenbaum DP, et al. Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. Science Translational Medicine. 10. PMID 30158152 DOI: 10.1126/Scitranslmed.Aam6474  0.344
2017 Kozuka K, He Y, Koo-McCoy S, Kumaraswamy P, Nie B, Shaw K, Chan P, Leadbetter M, He L, Lewis JG, Zhong Z, Charmot D, Balaa M, King AJ, Caldwell JS, ... Siegel M, et al. Development and Characterization of a Human and Mouse Intestinal Epithelial Cell Monolayer Platform. Stem Cell Reports. PMID 29153987 DOI: 10.1016/J.Stemcr.2017.10.013  0.325
2012 Siegel M, Garber ME, Spencer AG, Botwick W, Kumar P, Williams RN, Kozuka K, Shreeniwas R, Pratha V, Adelman DC. Safety, tolerability, and activity of ALV003: results from two phase 1 single, escalating-dose clinical trials. Digestive Diseases and Sciences. 57: 440-50. PMID 21948339 DOI: 10.1007/S10620-011-1906-5  0.475
2011 Garber M, Siegel M, Khosla C, Voyksner J, Voyksner RD. Quantification of ALV003-Mediated Gluten Degradation Using Mass Spectrometry Gastroenterology. 140: S-642-S-643. DOI: 10.1016/S0016-5085(11)62661-9  0.43
2010 Tye-Din JA, Anderson RP, Ffrench RA, Brown GJ, Hodsman P, Siegel M, Botwick W, Shreeniwas R. The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo. Clinical Immunology (Orlando, Fla.). 134: 289-95. PMID 19942485 DOI: 10.1016/J.Clim.2009.11.001  0.327
2009 Bethune MT, Siegel M, Howles-Banerji S, Khosla C. Interferon-gamma released by gluten-stimulated celiac disease-specific intestinal T cells enhances the transepithelial flux of gluten peptides. The Journal of Pharmacology and Experimental Therapeutics. 329: 657-68. PMID 19218531 DOI: 10.1124/Jpet.108.148007  0.693
2008 Yuan L, Behdad A, Siegel M, Khosla C, Higashikubo R, Rich KM. Tissue transgluaminase 2 expression in meningiomas. Journal of Neuro-Oncology. 90: 125-32. PMID 18587533 DOI: 10.1007/S11060-008-9642-1  0.457
2008 Siegel M, Strnad P, Watts RE, Choi K, Jabri B, Omary MB, Khosla C. Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury. Plos One. 3: e1861. PMID 18365016 DOI: 10.1371/Journal.Pone.0001861  0.517
2008 Siegel M, Strnad P, Watts RE, Choi K, Jabri B, Adler G, Omary B, Khosla C. 1001 Extracellular Transglutaminase 2 Is Catalytically Inactive, But Is Transiently Activated Upon Tissue Injury in the Small Intestine Gastroenterology. 134: A-151. DOI: 10.1016/S0016-5085(08)60701-5  0.474
2007 Xia J, Bergseng E, Fleckenstein B, Siegel M, Kim CY, Khosla C, Sollid LM. Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease. Bioorganic & Medicinal Chemistry. 15: 6565-73. PMID 17681795 DOI: 10.1016/J.Bmc.2007.07.001  0.619
2007 Gass J, Bethune MT, Siegel M, Spencer A, Khosla C. Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue. Gastroenterology. 133: 472-80. PMID 17681168 DOI: 10.1053/J.Gastro.2007.05.028  0.74
2007 Siegel M, Xia J, Khosla C. Structure-based design of alpha-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2. Bioorganic & Medicinal Chemistry. 15: 6253-61. PMID 17590341 DOI: 10.1016/J.Bmc.2007.06.020  0.625
2007 Siegel M, Khosla C. Transglutaminase 2 inhibitors and their therapeutic role in disease states. Pharmacology & Therapeutics. 115: 232-45. PMID 17582505 DOI: 10.1016/J.Pharmthera.2007.05.003  0.527
2007 Strnad P, Harada M, Siegel M, Terkeltaub RA, Graham RM, Khosla C, Omary MB. Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement. Gastroenterology. 132: 1515-26. PMID 17408647 DOI: 10.1053/J.Gastro.2007.02.020  0.471
2007 Yuan L, Siegel M, Choi K, Khosla C, Miller CR, Jackson EN, Piwnica-Worms D, Rich KM. Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy. Oncogene. 26: 2563-73. PMID 17099729 DOI: 10.1038/Sj.Onc.1210048  0.498
2006 Watts RE, Siegel M, Khosla C. Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles. Journal of Medicinal Chemistry. 49: 7493-501. PMID 17149878 DOI: 10.1021/Jm060839A  0.524
2006 Siegel M, Bethune MT, Gass J, Ehren J, Xia J, Johannsen A, Stuge TB, Gray GM, Lee PP, Khosla C. Rational design of combination enzyme therapy for celiac sprue. Chemistry & Biology. 13: 649-58. PMID 16793522 DOI: 10.1016/J.Chembiol.2006.04.009  0.661
2006 Strnad P, Siegel M, Toivola DM, Choi K, Kosek JC, Khosla C, Omary MB. Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation. Febs Letters. 580: 2351--2357. PMID 16616523 DOI: 10.1016/J.Febslet.2006.03.051  0.486
2006 Xia J, Siegel M, Bergseng E, Sollid LM, Khosla C. Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from alpha2-gliadin. Journal of the American Chemical Society. 128: 1859-67. PMID 16464085 DOI: 10.1021/Ja056423O  0.633
2005 Pyle GG, Paaso B, Anderson BE, Allen DD, Marti T, Li Q, Siegel M, Khosla C, Gray GM. Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprue. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 3: 687-94. PMID 16206502 DOI: 10.1016/S1542-3565(05)00366-6  0.489
2005 Choi K, Siegel M, Piper JL, Yuan L, Cho E, Strnad P, Omary B, Rich KM, Khosla C. Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2. Chemistry & Biology. 12: 469-75. PMID 15850984 DOI: 10.1016/J.Chembiol.2005.02.007  0.72
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