| Year |
Citation |
Score |
| 2023 |
Marchetti F, Cardoso R, Chen CL, Douglas GR, Elloway J, Escobar PA, Harper T, Heflich RH, Kidd D, Lynch AM, Myers MB, Parsons BL, Salk JJ, Settivari RS, Smith-Roe SL, et al. Error-corrected next generation sequencing - Promises and challenges for genotoxicity and cancer risk assessment. Mutation Research. Reviews in Mutation Research. 792: 108466. PMID 37643677 DOI: 10.1016/j.mrrev.2023.108466 |
0.708 |
|
| 2023 |
Marchetti F, Cardoso R, Chen CL, Douglas GR, Elloway J, Escobar PA, Harper T, Heflich RH, Kidd D, Lynch AM, Myers MB, Parsons BL, Salk JJ, Settivari RS, Smith-Roe SL, et al. Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing. Nature Reviews. Drug Discovery. PMID 36646809 DOI: 10.1038/d41573-023-00014-y |
0.64 |
|
| 2021 |
Mittelstaedt RA, Dad A, Pearce MG, Heflich RH, Cao X. Effect of life stage and target tissue on dose-response assessment of ethyl methane sulfonate-induced genotoxicity. Environmental and Molecular Mutagenesis. PMID 34647641 DOI: 10.1002/em.22465 |
0.31 |
|
| 2021 |
Dad A, Revollo JR, Pearce MG, McKinzie PB, Heflich RH, Dobrovolsky VN. Pig-a gene mutations in bone marrow granulocytes of procarbazine-treated F344 rats. Environmental and Molecular Mutagenesis. PMID 33666279 DOI: 10.1002/em.22430 |
0.339 |
|
| 2020 |
Dad A, Dobrovolsky VN, Heflich RH, Revollo JR. Molecular analysis of GPI-anchor biosynthesis pathway genes in rat strains used for the Pig-a gene mutation assay. Mutation Research. 858: 503256. PMID 33198937 DOI: 10.1016/j.mrgentox.2020.503256 |
0.315 |
|
| 2020 |
Dobrovolsky VN, Shaddock JG, Heflich RH. Analysis of In Vivo Mutation in the Hprt and Tk Genes of Mouse Lymphocytes. Methods in Molecular Biology (Clifton, N.J.). 2102: 333-348. PMID 31989565 DOI: 10.1007/978-1-0716-0223-2_19 |
0.33 |
|
| 2020 |
Dobrovolsky VN, Cao X, Bhalli JA, Heflich RH. Detection of Pig-a Mutant Erythrocytes in the Peripheral Blood of Rats and Mice. Methods in Molecular Biology (Clifton, N.J.). 2102: 315-331. PMID 31989564 DOI: 10.1007/978-1-0716-0223-2_18 |
0.329 |
|
| 2019 |
Bemis JC, Heflich RH. In vitro mammalian cell mutation assays based on the Pig-a gene: A report of the 7th International Workshop on Genotoxicity Testing (IWGT) Workgroup. Mutation Research. 847: 403028. PMID 31699348 DOI: 10.1016/J.Mrgentox.2019.03.001 |
0.414 |
|
| 2019 |
Heflich RH, Johnson GE, Zeller A, Marchetti F, Douglas GR, Witt KL, Gollapudi BB, White PA. Commentary: Mutation as a toxicological endpoint for regulatory decision-making. Environmental and Molecular Mutagenesis. PMID 31600846 DOI: 10.1002/Em.22338 |
0.408 |
|
| 2019 |
Dobrovolsky VN, Shaddock JG, Mittelstaedt RA, Miura D, Heflich RH. Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes. Methods in Molecular Biology (Clifton, N.J.). 2031: 59-75. PMID 31473954 DOI: 10.1007/978-1-4939-9646-9_3 |
0.338 |
|
| 2019 |
Shemansky JM, McDaniel LP, Klimas C, Dertinger SD, Dobrovolsky VN, Kimoto T, Horibata K, Polli JE, Heflich RH. Pig-a gene mutation database. Environmental and Molecular Mutagenesis. PMID 31090953 DOI: 10.1002/Em.22298 |
0.409 |
|
| 2019 |
Mittelstaedt RA, Dobrovolsky VN, Revollo JR, Pearce MG, Wang Y, Dad A, McKinzie PB, Rosenfeldt H, Yucesoy B, Yeager R, Hu SC, Tang Y, Min S, Kang HK, Yang DJ, ... ... Heflich RH, et al. Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays. Mutation Research. 837: 65-72. PMID 30595212 DOI: 10.1016/J.Mrgentox.2018.10.007 |
0.426 |
|
| 2018 |
Dad A, Revollo JR, Petibone DM, Pearce MG, Heflich RH, Dobrovolsky VN. Analysis of mutation in the rat Pig-a (assay: II) studies with bone marrow granulocytes. Environmental and Molecular Mutagenesis. PMID 30091248 DOI: 10.1002/Em.22210 |
0.418 |
|
| 2017 |
Revollo J, Wang Y, McKinzie P, Dad A, Pearce M, Heflich RH, Dobrovolsky VN. Spectrum of benzo[a]pyrene-induced mutations in the Pig-a gene of L5178YTk(+/-) cells identified with next generation sequencing. Mutation Research. 824: 1-8. PMID 29150045 DOI: 10.1016/J.Mrgentox.2017.09.003 |
0.387 |
|
| 2017 |
Wang Y, Revollo J, McKinzie P, Pearce MG, Dad A, Yucesoy B, Rosenfeldt H, Heflich RH, Dobrovolsky VN. Establishing a novel Pig-a gene mutation assay in L5178YTk(+/-) mouse lymphoma cells. Environmental and Molecular Mutagenesis. PMID 29098723 DOI: 10.1002/Em.22152 |
0.419 |
|
| 2017 |
Dobrovolsky VN, Revollo J, Petibone DM, Heflich RH. In Vivo Rat T-Lymphocyte Pig-a Assay: Detection and Expansion of Cells Deficient in the GPI-Anchored CD48 Surface Marker for Analysis of Mutation in the Endogenous Pig-a Gene. Methods in Molecular Biology (Clifton, N.J.). 1641: 143-160. PMID 28748462 DOI: 10.1007/978-1-4939-7172-5_7 |
0.441 |
|
| 2015 |
Guo X, Heflich RH, Dial SL, Richter PA, Moore MM, Mei N. Quantitative analysis of the relative mutagenicity of five chemical constituents of tobacco smoke in the mouse lymphoma assay. Mutagenesis. PMID 26001754 DOI: 10.1093/Mutage/Gev039 |
0.339 |
|
| 2015 |
Gollapudi BB, Lynch AM, Heflich RH, Dertinger SD, Dobrovolsky VN, Froetschl R, Horibata K, Kenyon MO, Kimoto T, Lovell DP, Stankowski LF, White PA, Witt KL, Tanir JY. The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup. Mutation Research. Genetic Toxicology and Environmental Mutagenesis. 783: 23-35. PMID 25953398 DOI: 10.1016/J.Mrgentox.2014.09.007 |
0.358 |
|
| 2015 |
Heflich RH, Dobrovolsky VN, Dertinger SD. Continued progress in developing the Pig-a gene mutation assay. Mutagenesis. 30: 313-4. PMID 25934984 DOI: 10.1093/Mutage/Geu082 |
0.396 |
|
| 2015 |
Johnson GE, Slob W, Doak SH, Fellows MD, Gollapudi BB, Heflich RH, Rees BJ, Soeteman-Hernández LG, Verma JR, Wills JW, Jenkins GJS, White PA. New approaches to advance the use of genetic toxicology analyses for human health risk assessment Toxicology Research. 4: 667-676. DOI: 10.1039/C4Tx00118D |
0.331 |
|
| 2014 |
Johnson GE, Soeteman-Hernández LG, Gollapudi BB, Bodger OG, Dearfield KL, Heflich RH, Hixon JG, Lovell DP, MacGregor JT, Pottenger LH, Thompson CM, Abraham L, Thybaud V, Tanir JY, Zeiger E, et al. Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment. Environmental and Molecular Mutagenesis. 55: 609-23. PMID 24801602 DOI: 10.1002/Em.21870 |
0.301 |
|
| 2014 |
Dobrovolsky VN, Shaddock JG, Heflich RH. Analysis of in vivo mutation in the Hprt and Tk genes of mouse lymphocytes. Methods in Molecular Biology (Clifton, N.J.). 1105: 255-70. PMID 24623234 DOI: 10.1007/978-1-62703-739-6_20 |
0.44 |
|
| 2014 |
Dobrovolsky VN, Cao X, Bhalli JA, Heflich RH. Detection of Pig-a mutant erythrocytes in the peripheral blood of rats and mice. Methods in Molecular Biology (Clifton, N.J.). 1105: 205-21. PMID 24623231 DOI: 10.1007/978-1-62703-739-6_17 |
0.438 |
|
| 2014 |
Cao X, Mittelstaedt RA, Pearce MG, Allen BC, Soeteman-Hernández LG, Johnson GE, Bigger CA, Heflich RH. Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adult gpt-delta transgenic mice. Environmental and Molecular Mutagenesis. 55: 385-99. PMID 24535894 DOI: 10.1002/Em.21854 |
0.436 |
|
| 2013 |
Manjanatha MG, Cao X, Shelton SD, Mittelstaedt RA, Heflich RH. In vivo cII, gpt, and Spi⁻ gene mutation assays in transgenic mice and rats. Methods in Molecular Biology (Clifton, N.J.). 1044: 97-119. PMID 23896873 DOI: 10.1007/978-1-62703-529-3_5 |
0.469 |
|
| 2013 |
Dobrovolsky VN, Shaddock JG, Mittelstaedt RA, Miura D, Heflich RH. Detection of in vivo mutation in the Hprt and Pig-a genes of rat lymphocytes. Methods in Molecular Biology (Clifton, N.J.). 1044: 79-95. PMID 23896872 DOI: 10.1007/978-1-62703-529-3_4 |
0.445 |
|
| 2013 |
Guo X, Mittelstaedt RA, Guo L, Shaddock JG, Heflich RH, Bigger AH, Moore MM, Mei N. Nitroxide TEMPO: a genotoxic and oxidative stress inducer in cultured cells. Toxicology in Vitro : An International Journal Published in Association With Bibra. 27: 1496-502. PMID 23517621 DOI: 10.1016/J.Tiv.2013.02.019 |
0.365 |
|
| 2013 |
Bhalli JA, Ding W, Shaddock JG, Pearce MG, Dobrovolsky VN, Heflich RH. Evaluating the weak in vivo micronucleus response of a genotoxic carcinogen, aristolochic acids. Mutation Research. 753: 82-92. PMID 23500662 DOI: 10.1016/J.Mrgentox.2013.03.002 |
0.376 |
|
| 2012 |
Dobrovolsky VN, Heflich RH, Ferguson SA. The frequency of Pig-a mutant red blood cells in rats exposed in utero to N-ethyl-N-nitrosourea. Environmental and Molecular Mutagenesis. 53: 440-50. PMID 22730214 DOI: 10.1002/Em.21704 |
0.447 |
|
| 2012 |
Ding W, Petibone DM, Latendresse JR, Pearce MG, Muskhelishvili L, White GA, Chang CW, Mittelstaedt RA, Shaddock JG, McDaniel LP, Doerge DR, Morris SM, Bishop ME, Manjanatha MG, Aidoo A, ... Heflich RH, et al. In vivo genotoxicity of furan in F344 rats at cancer bioassay doses. Toxicology and Applied Pharmacology. 261: 164-71. PMID 22507866 DOI: 10.1016/J.Taap.2012.03.021 |
0.379 |
|
| 2012 |
McDaniel LP, Ding W, Dobrovolsky VN, Shaddock JG, Mittelstaedt RA, Doerge DR, Heflich RH. Genotoxicity of furan in Big Blue rats. Mutation Research. 742: 72-8. PMID 22200623 DOI: 10.1016/J.Mrgentox.2011.12.011 |
0.421 |
|
| 2012 |
Li Y, Chen DH, Yan J, Chen Y, Mittelstaedt RA, Zhang Y, Biris AS, Heflich RH, Chen T. Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay. Mutation Research. 745: 4-10. PMID 22138422 DOI: 10.1016/J.Mrgentox.2011.11.010 |
0.366 |
|
| 2011 |
Kimoto T, Chikura S, Suzuki K, Kobayashi Xm, Itano Y, Horibata K, Honma M, Dobrovolsky VN, Heflich RH, Miura D, Kasahara Y. Further development of the rat Pig-a mutation assay: measuring rat Pig-a mutant bone marrow erythroids and a high throughput assay for mutant peripheral blood reticulocytes. Environmental and Molecular Mutagenesis. 52: 774-83. PMID 22167888 DOI: 10.1002/Em.20677 |
0.395 |
|
| 2011 |
Bhalli JA, Pearce MG, Dobrovolsky VN, Heflich RH. Manifestation and persistence of Pig-a mutant red blood cells in C57BL/6 mice following single and split doses of N-ethyl-N-nitrosourea. Environmental and Molecular Mutagenesis. 52: 766-773. PMID 22167887 DOI: 10.1002/Em.20682 |
0.408 |
|
| 2011 |
Cammerer Z, Bhalli JA, Cao X, Coffing SL, Dickinson D, Dobo KL, Dobrovolsky VN, Engel M, Fiedler RD, Gunther WC, Heflich RH, Pearce MG, Shaddock JG, Shutsky T, Thiffeault CJ, et al. Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea-comparison with other in vivo genotoxicity endpoints. Environmental and Molecular Mutagenesis. 52: 721-30. PMID 22167886 DOI: 10.1002/Em.20686 |
0.417 |
|
| 2011 |
Dertinger SD, Heflich RH. In vivo assessment of Pig-a gene mutation-recent developments and assay validation. Environmental and Molecular Mutagenesis. 52: 681-4. PMID 22167884 DOI: 10.1002/Em.20685 |
0.378 |
|
| 2011 |
Bhalli JA, Shaddock JG, Pearce MG, Dobrovolsky VN, Cao X, Heflich RH, Vohr HW. Report on stage III Pig-a mutation assays using benzo[a]pyrene. Environmental and Molecular Mutagenesis. 52: 731-7. PMID 22052432 DOI: 10.1002/Em.20675 |
0.386 |
|
| 2011 |
Dertinger SD, Phonethepswath S, Weller P, Nicolette J, Murray J, Sonders P, Vohr HW, Shi J, Krsmanovic L, Gleason C, Custer L, Henwood A, Sweder K, Stankowski LF, Roberts DJ, ... ... Heflich RH, et al. International Pig-a gene mutation assay trial: evaluation of transferability across 14 laboratories. Environmental and Molecular Mutagenesis. 52: 690-8. PMID 21910140 DOI: 10.1002/Em.20672 |
0.36 |
|
| 2011 |
Dobrovolsky VN, Elespuru RK, Bigger CA, Robison TW, Heflich RH. Monitoring humans for somatic mutation in the endogenous PIG-a gene using red blood cells. Environmental and Molecular Mutagenesis. 52: 784-94. PMID 21826740 DOI: 10.1002/Em.20667 |
0.403 |
|
| 2011 |
Ali R, Mittelstaedt RA, Shaddock JG, Ding W, Bhalli JA, Khan QM, Heflich RH. Comparative analysis of micronuclei and DNA damage induced by Ochratoxin A in two mammalian cell lines. Mutation Research. 723: 58-64. PMID 21554981 DOI: 10.1016/J.Mrgentox.2011.04.002 |
0.352 |
|
| 2011 |
Kimoto T, Suzuki K, Kobayashi XM, Dobrovolsky VN, Heflich RH, Miura D, Kasahara Y. Manifestation of Pig-a mutant bone marrow erythroids and peripheral blood erythrocytes in mice treated with N-ethyl-N-nitrosourea: direct sequencing of Pig-a cDNA from bone marrow cells negative for GPI-anchored protein expression. Mutation Research. 723: 36-42. PMID 21549855 DOI: 10.1016/J.Mrgentox.2011.03.016 |
0.461 |
|
| 2011 |
Miura D, Shaddock JG, Mittelstaedt RA, Dobrovolsky VN, Kimoto T, Kasahara Y, Heflich RH. Analysis of mutations in the Pig-a gene of spleen T-cells from N-ethyl-N-nitrosourea-treated fisher 344 rats. Environmental and Molecular Mutagenesis. 52: 419-23. PMID 21542029 DOI: 10.1002/Em.20654 |
0.467 |
|
| 2011 |
Galloway S, Lorge E, Aardema MJ, Eastmond D, Fellows M, Heflich R, Kirkland D, Levy DD, Lynch AM, Marzin D, Morita T, Schuler M, Speit G. Workshop summary: Top concentration for in vitro mammalian cell genotoxicity assays; and report from working group on toxicity measures and top concentration for in vitro cytogenetics assays (chromosome aberrations and micronucleus). Mutation Research. 723: 77-83. PMID 21255675 DOI: 10.1016/J.Mrgentox.2011.01.003 |
0.305 |
|
| 2011 |
Rothfuss A, Honma M, Czich A, Aardema MJ, Burlinson B, Galloway S, Hamada S, Kirkland D, Heflich RH, Howe J, Nakajima M, O'Donovan M, Plappert-Helbig U, Priestley C, Recio L, et al. Improvement of in vivo genotoxicity assessment: combination of acute tests and integration into standard toxicity testing. Mutation Research. 723: 108-20. PMID 21182982 DOI: 10.1016/J.Mrgentox.2010.12.005 |
0.322 |
|
| 2010 |
Dobrovolsky VN, Miura D, Heflich RH, Dertinger SD. The in vivo Pig-a gene mutation assay, a potential tool for regulatory safety assessment. Environmental and Molecular Mutagenesis. 51: 825-35. PMID 20857433 DOI: 10.1002/Em.20627 |
0.455 |
|
| 2010 |
Valentine CR, Delongchamp RR, Pearce MG, Rainey HF, Dobrovolsky VN, Malling HV, Heflich RH. In vivo mutation analysis using the ΦX174 transgenic mouse and comparisons with other transgenes and endogenous genes. Mutation Research. 705: 205-16. PMID 20637298 DOI: 10.1016/J.Mrrev.2010.07.001 |
0.464 |
|
| 2010 |
Mei N, McDaniel LP, Dobrovolsky VN, Guo X, Shaddock JG, Mittelstaedt RA, Azuma M, Shelton SD, McGarrity LJ, Doerge DR, Heflich RH. The genotoxicity of acrylamide and glycidamide in big blue rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 115: 412-21. PMID 20200216 DOI: 10.1093/Toxsci/Kfq069 |
0.356 |
|
| 2010 |
Dobrovolsky VN, Boctor SY, Twaddle NC, Doerge DR, Bishop ME, Manjanatha MG, Kimoto T, Miura D, Heflich RH, Ferguson SA. Flow cytometric detection of Pig-A mutant red blood cells using an erythroid-specific antibody: application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats. Environmental and Molecular Mutagenesis. 51: 138-45. PMID 19658152 DOI: 10.1002/Em.20519 |
0.395 |
|
| 2010 |
Chen T, Heflich RH, Moore MM, Mei N. Differential mutagenicity of aflatoxin B1 in the liver of neonatal and adult mice. Environmental and Molecular Mutagenesis. 51: 156-63. PMID 19642212 DOI: 10.1002/Em.20518 |
0.386 |
|
| 2009 |
Myers MB, Mittelstaedt RA, Heflich RH. Using phiX174 DNA as an exogenous reference for measuring mitochondrial DNA copy number. Biotechniques. 47: 867-9. PMID 19852770 DOI: 10.2144/000113222 |
0.685 |
|
| 2009 |
Miura D, Dobrovolsky VN, Kimoto T, Kasahara Y, Heflich RH. Accumulation and persistence of Pig-A mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl-N-nitrosourea. Mutation Research. 677: 86-92. PMID 19501187 DOI: 10.1016/J.Mrgentox.2009.05.014 |
0.389 |
|
| 2009 |
Von Tungeln LS, Churchwell MI, Doerge DR, Shaddock JG, McGarrity LJ, Heflich RH, Gamboa da Costa G, Marques MM, Beland FA. DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide. International Journal of Cancer. 124: 2006-15. PMID 19123476 DOI: 10.1002/Ijc.24165 |
0.476 |
|
| 2008 |
Miura D, Dobrovolsky VN, Kasahara Y, Katsuura Y, Heflich RH. Development of an in vivo gene mutation assay using the endogenous Pig-A gene: I. Flow cytometric detection of CD59-negative peripheral red blood cells and CD48-negative spleen T-cells from the rat. Environmental and Molecular Mutagenesis. 49: 614-21. PMID 18626999 DOI: 10.1002/Em.20414 |
0.39 |
|
| 2008 |
Miura D, Dobrovolsky VN, Mittelstaedt RA, Kasahara Y, Katsuura Y, Heflich RH. Development of an in vivo gene mutation assay using the endogenous Pig-A gene: II. Selection of Pig-A mutant rat spleen T-cells with proaerolysin and sequencing Pig-A cDNA from the mutants. Environmental and Molecular Mutagenesis. 49: 622-30. PMID 18626996 DOI: 10.1002/Em.20413 |
0.418 |
|
| 2008 |
Moore MM, Heflich RH, Haber LT, Allen BC, Shipp AM, Kodell RL. Analysis of in vivo mutation data can inform cancer risk assessment. Regulatory Toxicology and Pharmacology : Rtp. 51: 151-61. PMID 18321622 DOI: 10.1016/J.Yrtph.2008.01.015 |
0.391 |
|
| 2007 |
Bendre SV, Shaddock JG, Dobrovolsky VN, Albertini RJ, Heflich RH. Effect of chronic azathioprine treatment on germ-line transmission of Hprt mutation in mice. Environmental and Molecular Mutagenesis. 48: 744-53. PMID 18008354 DOI: 10.1002/Em.20352 |
0.757 |
|
| 2007 |
Dobrovolsky VN, Heflich RH. On the use of the T-REx tetracycline-inducible gene expression system in vivo. Biotechnology and Bioengineering. 98: 719-23. PMID 17421042 DOI: 10.1002/Bit.21454 |
0.329 |
|
| 2007 |
Dobrovolsky VN, Shaddock JG, Mittelstaedt RA, Bishop ME, Lewis SM, Lee FW, Aidoo A, Leakey JE, Dunnick JK, Heflich RH. Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53-haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC. Environmental and Molecular Mutagenesis. 48: 270-82. PMID 17358030 DOI: 10.1002/Em.20280 |
0.357 |
|
| 2007 |
Tweats DJ, Blakey D, Heflich RH, Jacobs A, Jacobsen SD, Morita T, Nohmi T, O'Donovan MR, Sasaki YF, Sofuni T, Tice R. Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards. Mutation Research. 627: 78-91. PMID 17116417 DOI: 10.1016/J.Mrgentox.2006.10.005 |
0.304 |
|
| 2007 |
Wang J, Heflich RH, Moore MM. A method to distinguish between the de novo induction of thymidine kinase mutants and the selection of pre-existing thymidine kinase mutants in the mouse lymphoma assay. Mutation Research. 626: 185-90. PMID 17055776 DOI: 10.1016/J.Mrgentox.2006.09.002 |
0.423 |
|
| 2007 |
Von Tungeln LS, Williams LD, Doerge DR, Shaddock JG, McGarrity LJ, Morris SM, Mittelstaedt RA, Heflich RH, Beland FA. Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine. Environmental and Molecular Mutagenesis. 48: 258-69. PMID 16850453 DOI: 10.1002/Em.20237 |
0.403 |
|
| 2006 |
Mei N, Arlt VM, Phillips DH, Heflich RH, Chen T. DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver. Mutation Research. 602: 83-91. PMID 17010389 DOI: 10.1016/J.Mrfmmm.2006.08.004 |
0.433 |
|
| 2006 |
Shaddock JG, Dobrovolsky VN, Mittelstaedt RA, Heflich RH, Parsons BL. Frequency and types of spontaneous Hprt lymphocyte mutations in Pms2-deficient mice. Mutation Research. 595: 69-79. PMID 16336979 DOI: 10.1016/J.Mrfmmm.2005.10.007 |
0.481 |
|
| 2006 |
Parsons BL, Delongchamp RR, Beland FA, Heflich RH. Levels of H-ras codon 61 CAA to AAA mutation: response to 4-ABP-treatment and Pms2-deficiency. Mutagenesis. 21: 29-34. PMID 16314341 DOI: 10.1093/Mutage/Gei066 |
0.451 |
|
| 2005 |
Bendre SV, Shaddock JG, Patton RE, Dobrovolsky VN, Albertini RJ, Heflich RH. Lymphocyte Hprt mutant frequency and sperm toxicity in C57BL/6 mice treated chronically with Azathioprine. Mutation Research. 578: 1-14. PMID 16107271 DOI: 10.1016/j.mrfmmm.2004.09.018 |
0.764 |
|
| 2005 |
Chen T, Mittelstaedt RA, Beland FA, Heflich RH, Moore MM, Parsons BL. 4-Aminobiphenyl induces liver DNA adducts in both neonatal and adult mice but induces liver mutations only in neonatal mice. International Journal of Cancer. Journal International Du Cancer. 117: 182-7. PMID 15880493 DOI: 10.1002/Ijc.21173 |
0.453 |
|
| 2005 |
Dobrovolsky VN, Bowyer JF, Pabarcus MK, Heflich RH, Williams LD, Doerge DR, Arvidsson B, Bergquist J, Casida JE. Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype. Biochimica Et Biophysica Acta. 1724: 163-72. PMID 15866519 DOI: 10.1016/J.Bbagen.2005.03.010 |
0.356 |
|
| 2005 |
Mei N, Heflich RH, Moore MM, Chen T. Age-dependent sensitivity of Big Blue transgenic mice to the mutagenicity of N-ethyl-N-nitrosourea (ENU) in liver. Mutation Research. 572: 14-26. PMID 15790487 DOI: 10.1016/J.Mrfmmm.2004.11.011 |
0.471 |
|
| 2005 |
Parsons BL, Beland FA, Von Tungeln LS, Delongchamp RR, Fu PP, Heflich RH. Levels of 4-aminobiphenyl-induced somatic H-ras mutation in mouse liver DNA correlate with potential for liver tumor development. Molecular Carcinogenesis. 42: 193-201. PMID 15761837 DOI: 10.1002/Mc.20083 |
0.44 |
|
| 2005 |
Mei N, Guo L, Fu PP, Heflich RH, Chen T. Mutagenicity of comfrey (Symphytum Officinale) in rat liver. British Journal of Cancer. 92: 873-5. PMID 15726100 DOI: 10.1038/Sj.Bjc.6602420 |
0.332 |
|
| 2005 |
Dobrovolsky VN, McGarrity LJ, VonTungeln LS, Mittelstaedt RA, Morris SM, Beland FA, Heflich RH. Micronucleated erythrocyte frequency in control and azidothymidine-treated Tk+/+, Tk+/- and Tk-/- mice. Mutation Research. 570: 227-35. PMID 15708581 DOI: 10.1016/J.Mrfmmm.2004.11.006 |
0.378 |
|
| 2005 |
Parsons BL, McKinzie PB, Heflich RH. Allele-specific competitive blocker-PCR detection of rare base substitution. Methods in Molecular Biology (Clifton, N.J.). 291: 235-45. PMID 15502227 DOI: 10.1385/1-59259-840-4:235 |
0.373 |
|
| 2005 |
Dobrovolsky VN, Shaddock JG, Heflich RH. Analysis of in vivo mutation in the hprt and tk genes of mouse lymphocytes. Methods in Molecular Biology (Clifton, N.J.). 291: 133-44. PMID 15502218 |
0.329 |
|
| 2004 |
Mei N, Chou MW, Fu PP, Heflich RH, Chen T. Differential mutagenicity of riddelliine in liver endothelial and parenchymal cells of transgenic big blue rats. Cancer Letters. 215: 151-8. PMID 15488633 DOI: 10.1016/J.Canlet.2004.06.013 |
0.411 |
|
| 2004 |
Wang J, Liu X, Heflich RH, Chen T. Time course of cII gene mutant manifestation in the liver, spleen, and bone marrow of N-ethyl-N-nitrosourea-treated Big Blue transgenic mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 82: 124-8. PMID 15282403 DOI: 10.1093/Toxsci/Kfh234 |
0.41 |
|
| 2004 |
Mittelstaedt RA, Mei N, Webb PJ, Shaddock JG, Dobrovolsky VN, McGarrity LJ, Morris SM, Chen T, Beland FA, Greenlees KJ, Heflich RH. Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice. Mutation Research. 561: 127-38. PMID 15238237 DOI: 10.1016/J.Mrgentox.2004.04.003 |
0.428 |
|
| 2004 |
Von Tungeln LS, Dobrovolsky VN, Bishop ME, Shaddock JG, Heflich RH, Beland FA. Frequency of Tk and Hprt lymphocyte mutants and bone marrow micronuclei in mice treated neonatally with zidovudine and didanosine. Mutagenesis. 19: 307-11. PMID 15215330 DOI: 10.1093/Mutage/Geh033 |
0.463 |
|
| 2004 |
Mei N, Heflich RH, Chou MW, Chen T. Mutations induced by the carcinogenic pyrrolizidine alkaloid riddelliine in the liver cII gene of transgenic big blue rats. Chemical Research in Toxicology. 17: 814-8. PMID 15206902 DOI: 10.1021/Tx049955B |
0.478 |
|
| 2004 |
Mittelstaedt RA, Von Tungeln LS, Shaddock JG, Dobrovolsky VN, Beland FA, Heflich RH. Analysis of mutations in the Tk gene of Tk(+/-) mice treated as neonates with 3'-azido-3'-deoxythymidine (AZT). Mutation Research. 547: 63-9. PMID 15013700 DOI: 10.1016/J.Mrfmmm.2003.12.008 |
0.437 |
|
| 2004 |
Manjanatha MG, Shelton SD, Bishop M, Shaddock JG, Dobrovolsky VN, Heflich RH, Webb PJ, Blankenship LR, Beland FA, Greenlees KJ, Culp SJ. Analysis of mutations and bone marrow micronuclei in Big Blue rats fed leucomalachite green. Mutation Research. 547: 5-18. PMID 15013694 DOI: 10.1016/J.Mrfmmm.2003.11.009 |
0.438 |
|
| 2003 |
Thybaud V, Dean S, Nohmi T, de Boer J, Douglas GR, Glickman BW, Gorelick NJ, Heddle JA, Heflich RH, Lambert I, Martus HJ, Mirsalis JC, Suzuki T, Yajima N. In vivo transgenic mutation assays. Mutation Research. 540: 141-51. PMID 14550498 DOI: 10.1016/J.Mrgentox.2003.07.004 |
0.407 |
|
| 2003 |
Dobrovolsky VN, McKinzie PB, Shaddock JG, Mittelstaedt RA, Heflich RH, Parsons BL. Pms2 deficiency results in increased mutation in the Hprt gene but not the Tk gene of Tk(+/-) transgenic mice. Mutagenesis. 18: 365-70. PMID 12840110 DOI: 10.1093/Mutage/Geg007 |
0.471 |
|
| 2003 |
Aidoo A, Mittelstaedt RA, Bishop ME, Lyn-Cook LE, Chen YJ, Duffy P, Heflich RH. Effect of caloric restriction on Hprt lymphocyte mutation in aging rats. Mutation Research. 527: 57-66. PMID 12787914 DOI: 10.1016/S0027-5107(03)00072-1 |
0.342 |
|
| 2003 |
Khaidakov M, Heflich RH, Manjanatha MG, Myers MB, Aidoo A. Accumulation of point mutations in mitochondrial DNA of aging mice. Mutation Research. 526: 1-7. PMID 12714177 DOI: 10.1016/S0027-5107(03)00010-1 |
0.75 |
|
| 2003 |
Dobrovolsky VN, Bucci T, Heflich RH, Desjardins J, Richardson FC. Mice deficient for cytosolic thymidine kinase gene develop fatal kidney disease. Molecular Genetics and Metabolism. 78: 1-10. PMID 12559842 DOI: 10.1016/S1096-7192(02)00224-X |
0.389 |
|
| 2002 |
Culp SJ, Beland FA, Heflich RH, Benson RW, Blankenship LR, Webb PJ, Mellick PW, Trotter RW, Shelton SD, Greenlees KJ, Manjanatha MG. Mutagenicity and carcinogenicity in relation to DNA adduct formation in rats fed leucomalachite green. Mutation Research. 55-63. PMID 12351145 DOI: 10.1016/S0027-5107(02)00152-5 |
0.39 |
|
| 2002 |
Von Tungeln LS, Hamilton LP, Dobrovolsky VN, Bishop ME, Shaddock JG, Heflich RH, Beland FA. Frequency of Tk and Hprt lymphocyte mutants and bone marrow micronuclei in B6C3F(1)/Tk+/- mice treated neonatally with zidovudine and lamivudine. Carcinogenesis. 23: 1427-32. PMID 12189183 DOI: 10.1093/Carcin/23.9.1427 |
0.413 |
|
| 2002 |
Dobrovolsky VN, Shaddock JG, Heflich RH. Mutagenicity of gamma-radiation, mitomycin C, and etoposide in the Hprt and Tk genes of Tk(+/-) mice. Environmental and Molecular Mutagenesis. 39: 342-7. PMID 12112386 DOI: 10.1002/Em.10074 |
0.394 |
|
| 2002 |
Parsons BL, Culp SJ, Manjanatha MG, Heflich RH. Occurrence of H-ras codon 61 CAA to AAA mutation during mouse liver tumor progression. Carcinogenesis. 23: 943-8. PMID 12082015 DOI: 10.1093/Carcin/23.6.943 |
0.386 |
|
| 2002 |
Dobrovolsky VN, McGarrity LJ, Morris SM, Heflich RH. Detection of mutation in transgenic CHO cells using green fluorescent protein as a reporter. Mutation Research. 518: 55-64. PMID 12063067 DOI: 10.1016/S1383-5718(02)00072-4 |
0.381 |
|
| 2002 |
Fu PP, Von Tungeln LS, Xia Q, Zhan D, Heflich RH. Effect of Nitro Orientation on Ras -Protooncogene Mutation in Liver Tumors from 7-Nitrodibenz[ a,h ]anthracene-Treated Mice Polycyclic Aromatic Compounds. 22: 853-859. DOI: 10.1080/10406630290104004 |
0.33 |
|
| 2001 |
McKinzie PB, Delongchamp RR, Heflich RH, Parsons BL. Prospects for applying genotypic selection of somatic oncomutation to chemical risk assessment. Mutation Research. 489: 47-78. PMID 11673089 DOI: 10.1016/S1383-5742(01)00063-1 |
0.393 |
|
| 2001 |
Gamboa da Costa G, McDaniel-Hamilton LP, Heflich RH, Marques MM, Beland FA. DNA adduct formation and mutant induction in Sprague-Dawley rats treated with tamoxifen and its derivatives. Carcinogenesis. 22: 1307-15. PMID 11470763 DOI: 10.1093/Carcin/22.8.1307 |
0.331 |
|
| 2001 |
Chen T, Mittelstaedt RA, Shelton SD, Dass SB, Manjanatha MG, Casciano DA, Heflich RH. Gene- and tissue-specificity of mutation in Big Blue rats treated with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene. Environmental and Molecular Mutagenesis. 37: 203-14. PMID 11317338 DOI: 10.1002/Em.1029 |
0.474 |
|
| 2001 |
Chen T, Mittelstaedt RA, Aidoo A, Hamilton LP, Beland FA, Casciano DA, Heflich RH. Comparison of hprt and lacI mutant frequency with DNA adduct formation in N-hydroxy-2-acetylaminofluorene-treated Big Blue rats. Environmental and Molecular Mutagenesis. 37: 195-202. PMID 11317337 DOI: 10.1002/Em.1028 |
0.412 |
|
| 2000 |
Von Tungeln LS, Xia Q, Herreno-Saenz D, Bucci TJ, Heflich RH, Fu PP. Tumorigenicity of nitropolycyclic aromatic hydrocarbons in the neonatal B6C3F1 mouse bioassay and characterization of ras mutations in liver tumors from treated mice. Cancer Letters. 146: 1-7. PMID 10656603 DOI: 10.1016/S0304-3835(99)00206-2 |
0.373 |
|
| 2000 |
Meng Q, Singh N, Heflich RH, Bauer MJ, Walker VE. Comparison of the mutations at Hprt exon 3 of T-lymphocytes from B6C3F1 mice and F344 rats exposed by inhalation to 1,3-butadiene or the racemic mixture of 1,2:3,4-diepoxybutane Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 464: 169-184. PMID 10648904 DOI: 10.1016/S1383-5718(99)00157-6 |
0.479 |
|
| 1999 |
Mittelstaedt RA, Smith BA, Chen T, Beland FA, Heflich RH. Sequence specificity of Hprt lymphocyte mutation in rats fed the hepatocarcinogen 2-acetylaminofluorene. Mutation Research. 431: 167-73. PMID 10656495 DOI: 10.1016/S0027-5107(99)00204-3 |
0.424 |
|
| 1999 |
Casciano DA, Aidoo A, Chen T, Mittelstaedt RA, Manjanatha MG, Heflich RH. Hprt mutant frequency and molecular analysis of Hprt mutations in rats treated with mutagenic carcinogens. Mutation Research. 431: 389-95. PMID 10636003 DOI: 10.1016/S0027-5107(99)00181-5 |
0.32 |
|
| 1999 |
Chen JB, Dobrovolsky VN, Heflich RH. Development of a mouse cell line containing the PhiX174 am3 allele as a target for detecting mutation. Mutation Research. 444: 347-53. PMID 10521674 DOI: 10.1016/S1383-5718(99)00099-6 |
0.443 |
|
| 1999 |
Beland FA, Fullerton NF, Smith BA, Mittelstaedt RA, Heflich RH. Hprt lymphocyte mutant frequency in relation to DNA adduct formation in rats fed the hepatocarcinogen 2-acetylaminofluorene. Cancer Letters. 143: 249-55. PMID 10503913 DOI: 10.1016/S0304-3835(99)00134-2 |
0.411 |
|
| 1999 |
Dass SB, Bucci TJ, Heflich RH, Casciano DA. Evaluation of the transgenic p53+/- mouse for detecting genotoxic liver carcinogens in a short-term bioassay. Cancer Letters. 143: 81-5. PMID 10465341 DOI: 10.1016/S0304-3835(99)00196-2 |
0.343 |
|
| 1999 |
Dobrovolsky VN, Chen T, Heflich RH. Molecular analysis of in vivo mutations induced by N-ethyl-N-nitrosourea in the autosomal Tk and the X-linked Hprt genes of mouse lymphocytes. Environmental and Molecular Mutagenesis. 34: 30-8. PMID 10462721 DOI: 10.1002/(Sici)1098-2280(1999)34:1<30::Aid-Em5>3.0.Co;2-R |
0.455 |
|
| 1999 |
Meng Q, Henderson RF, Chen T, Heflich RH, Walker DM, Bauer MJ, Reilly AA, Walker VE. Mutagenicity of 1,3-butadiene at the Hprt locus of T-lymphocytes following inhalation exposures of female mice and rats Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 429: 107-125. PMID 10434027 DOI: 10.1016/S0027-5107(99)00104-9 |
0.454 |
|
| 1999 |
Von Tungeln LS, Xia Q, Bucci T, Heflich RH, Fu PP. Tumorigenicity and liver tumor ras-protooncogene mutations in CD-1 mice treated neonatally with 1- and 3-nitrobenzo[a]pyrene and their trans-7,8-dihydrodiol and aminobenzo[a]pyrene metabolites. Cancer Letters. 137: 137-43. PMID 10374834 DOI: 10.1016/S0304-3835(98)00341-3 |
0.408 |
|
| 1999 |
Delongchamp RR, Malling HV, Chen JB, Heflich RH. An estimator of the mutant frequency in assays using transgenic animals. Mutation Research. 440: 101-8. PMID 10095133 DOI: 10.1016/S1383-5718(99)00007-8 |
0.332 |
|
| 1999 |
Chen T, Aidoo A, Mittelstaedt RA, Casciano DA, Heflich RH. Hprt mutant frequency and molecular analysis of Hprt mutations in Fischer 344 rats treated with thiotepa. Carcinogenesis. 20: 269-77. PMID 10069464 DOI: 10.1093/Carcin/20.2.269 |
0.483 |
|
| 1999 |
Dobrovolsky VN, Casciano DA, Heflich RH. Tk+/- mouse model for detecting in vivo mutation in an endogenous, autosomal gene. Mutation Research. 423: 125-36. PMID 10029690 DOI: 10.1016/S0027-5107(98)00234-6 |
0.454 |
|
| 1999 |
Parsons BL, Heflich RH. Detection of a mouse H-ras codon 61 mutation using a modified allele-specific competitive blocker PCR genotypic selection method. Mutagenesis. 13: 581-8. PMID 9862188 DOI: 10.1093/Mutage/13.6.581 |
0.398 |
|
| 1998 |
Chen JB, Dass SB, Burkhart JG, Heflich RH. Sensitivity of the phiX174 am3 allele in relation to the endogenous Hprt gene for detecting mutation in transgenic mice. Environmental and Molecular Mutagenesis. 32: 229-35. PMID 9814437 DOI: 10.1002/(Sici)1098-2280(1998)32:3<229::Aid-Em5>3.0.Co;2-0 |
0.468 |
|
| 1998 |
Parsons BL, Heflich RH. Detection of basepair substitution mutation at a frequency of 1 x 10(-7) by combining two genotypic selection methods, MutEx enrichment and allele-specific competitive blocker PCR. Environmental and Molecular Mutagenesis. 32: 200-11. PMID 9814434 DOI: 10.1002/(Sici)1098-2280(1998)32:3<200::Aid-Em2>3.0.Co;2-O |
0.42 |
|
| 1998 |
Chen T, Aidoo A, Manjanatha MG, Mittelstaedt RA, Shelton SD, Lyn-Cook LE, Casciano DA, Heflich RH. Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue rats. Mutation Research. 403: 199-214. PMID 9726020 DOI: 10.1016/S0027-5107(98)00080-3 |
0.461 |
|
| 1998 |
Dass SB, Heflich RH, Casciano DA. Mutational response at the splenic T-lymphocyte hprt locus in mice treated as neonates: contrasting effects of the carcinogens N-ethyl-N-nitrosourea, dimethylnitrosamine, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Environmental and Molecular Mutagenesis. 31: 243-7. PMID 9585262 DOI: 10.1002/(Sici)1098-2280(1998)31:3<243::Aid-Em5>3.0.Co;2-L |
0.465 |
|
| 1998 |
Mittelstaedt RA, Manjanatha MG, Shelton SD, Lyn-Cook LE, Chen JB, Aidoo A, Casciano DA, Heflich RH. Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in the lacI and hprt genes of Big Blue rats. Environmental and Molecular Mutagenesis. 31: 149-56. PMID 9544192 DOI: 10.1002/(Sici)1098-2280(1998)31:2<149::Aid-Em6>3.0.Co;2-H |
0.427 |
|
| 1998 |
Dass SB, Hammons GJ, Bucci TJ, Heflich RH, Casciano DA. Susceptibility of C57BL/6 mice to tumorigenicity induced by dimethylnitrosamine and 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine in the neonatal bioassay. Cancer Letters. 124: 105-10. PMID 9500198 DOI: 10.1016/S0304-3835(97)00462-X |
0.313 |
|
| 1998 |
Chen T, Aidoo A, Casciano DA, Heflich RH. Expansion of rat 6-thioguanine-resistant T-lymphocyte clones by stimulation with ionomycin and a phorbol ester. Environmental and Molecular Mutagenesis. 31: 97-102. PMID 9464321 DOI: 10.1002/(Sici)1098-2280(1998)31:1<97::Aid-Em13>3.0.Co;2-K |
0.389 |
|
| 1998 |
Zhan DJ, Chiu LH, Heflich RH, Fu PP. Molecular characterization of hprt mutations from Chinese hamster ovary cells treated with 1-, 3-, and 6-nitrosobenzo[a]pyrene. Environmental and Molecular Mutagenesis. 31: 60-9. PMID 9464317 DOI: 10.1002/(Sici)1098-2280(1998)31:1<60::Aid-Em9>3.0.Co;2-F |
0.412 |
|
| 1998 |
Xia Q, Yi P, Zhan DJ, Von Tungeln LS, Hart RW, Heflich RH, Fu PP. Liver tumors induced in B6C3F1 mice by 7-chlorobenz[a]anthracene and 7-bromobenz[a]anthracene contain K-ras protooncogene mutations. Cancer Letters. 123: 21-5. PMID 9461013 DOI: 10.1016/S0304-3835(97)00366-2 |
0.343 |
|
| 1998 |
Dass SB, Ali SF, Heflich RH, Casciano DA. Frequency of spontaneous and induced micronuclei in the peripheral blood of aging mice. Mutation Research. 381: 105-10. PMID 9403036 DOI: 10.1016/S0027-5107(97)00156-5 |
0.403 |
|
| 1997 |
Dass SB, Heflich RH, Casciano DA. The mutagenic response at the ouabain resistance locus in T cells of mice exposed to N-ethyl-N-nitrosourea parallels the response at the Hprt locus and correlates with mutation target size. Carcinogenesis. 18: 2233-7. PMID 9395226 DOI: 10.1093/Carcin/18.11.2233 |
0.416 |
|
| 1997 |
Parsons BL, Heflich RH. Genotypic selection methods for the direct analysis of point mutations. Mutation Research. 387: 97-121. PMID 9372853 DOI: 10.1016/S1383-5742(97)00026-4 |
0.365 |
|
| 1997 |
Smith BA, Manjanatha MG, Pogribny IP, Mittelstaedt RA, Chen T, Fullerton NF, Beland FA, Heflich RH. Analysis of mutations in the K-ras and p53 genes of lung tumors and in the hprt gene of 6-thioguanine-resistant T-lymphocytes from rats treated with 1,6-dinitropyrene. Mutation Research. 379: 61-8. PMID 9330623 DOI: 10.1016/S0027-5107(97)00107-3 |
0.417 |
|
| 1997 |
Zhan DJ, Chiu LH, Von Tungeln LS, Herreno-Saenz D, Cheng E, Evans FE, Heflich RH, Fu PP. Characterization of DNA adducts in Chinese hamster ovary cells treated with mutagenic doses of 1- and 3-nitrosobenzo[a]pyrene and the trans-7,8-diol-anti-9,10-epoxides of 1- and 3-nitrobenzo[a]pyrene. Mutation Research. 379: 43-52. PMID 9330621 DOI: 10.1016/S0027-5107(97)00105-X |
0.352 |
|
| 1997 |
Fu PP, Qui FY, Jung H, Von Tungeln LS, Zhan DJ, Lee MJ, Wu YS, Heflich RH. Metabolism of isomeric nitrobenzo[a]pyrenes leading to DNA adducts and mutagenesis Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 376: 43-51. PMID 9202737 DOI: 10.1016/S0027-5107(97)00024-9 |
0.305 |
|
| 1997 |
Parsons BL, Heflich RH. Evaluation of MutS as a tool for direct measurement of point mutations in genomic DNA. Mutation Research. 374: 277-85. PMID 9100851 DOI: 10.1016/S0027-5107(96)00245-X |
0.427 |
|
| 1997 |
Dobrovolsky VN, Casciano DA, Heflich RH. Development of a novel mouse tk+/- embryonic stem cell line for use in mutagenicity studies. Environmental and Molecular Mutagenesis. 28: 483-9. PMID 8991081 DOI: 10.1002/(Sici)1098-2280(1996)28:4<483::Aid-Em26>3.0.Co;2-A |
0.379 |
|
| 1997 |
Casciano DA, Heflich RH, Aidoo A, Manjanatha MG. P XV.10 Quantitative and molecular analysis of DMBA-induced mutations in the model BlueRat™″: Comparison of mutagenesis in the transgene lacI with the endogenous gene hprt Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 379: S148. DOI: 10.1016/S0027-5107(97)83130-2 |
0.379 |
|
| 1996 |
Manjanatha MG, Lyn-Cook LE, Culp SJ, Beland FA, Heflich RH, Aidoo A. Lymphocyte mutant frequency in relation to DNA adduct formation in rats treated with tumorigenic doses of the mammary gland carcinogen 7,12-dimethylbenz[a]anthracene. Mutation Research. 357: 89-96. PMID 8876684 DOI: 10.1016/0027-5107(96)00086-3 |
0.405 |
|
| 1996 |
Heflich RH, Mittelstaedt RA, Manjanatha MG, Lyn-Cook LE, Aidoo A. DNA sequence analysis of hprt mutations in lymphocytes from Sprague-Dawley rats treated with 7,12-dimethylbenz[a]anthracene. Environmental and Molecular Mutagenesis. 28: 5-12. PMID 8698046 DOI: 10.1002/(Sici)1098-2280(1996)28:1<5::Aid-Em3>3.0.Co;2-G |
0.46 |
|
| 1996 |
Zhan DJ, Heflich RH, Fu PP. Molecular characterization of mutation and comparison of mutation profiles in the hprt gene of Chinese hamster ovary cells treated with benzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, 1-nitrobenzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, and 3-nitrobenzo[a]pyrene trans-7,8- diol-anti-9,10-epoxide. Environmental and Molecular Mutagenesis. 27: 19-29. PMID 8625944 DOI: 10.1002/(Sici)1098-2280(1996)27:1<19::Aid-Em3>3.0.Co;2-9 |
0.454 |
|
| 1996 |
Delclos K, Blaydes B, Heflich RH, Smith BA. Assessment of DNA adducts and the frequency of 6-thioguanine resistant T-lymphocytes in F344 rats fed 2,4-toluenediamine or implanted with a toluenediisocyanate-containing polyester polyurethane foam Mutation Research/Genetic Toxicology. 367: 209-218. DOI: 10.1016/S0165-1218(96)90079-8 |
0.402 |
|
| 1996 |
Casciano D, Aidoo A, Heflich R, Lyn-Cook L, Mittelstaedt R, Manjanatha M. Development and characterization of an in vivo somatic mutation assay Mutation Research/Environmental Mutagenesis and Related Subjects. 360: 202-203. DOI: 10.1016/S0165-1161(96)90020-5 |
0.403 |
|
| 1995 |
Mittelstaedt RA, Smith BA, Heflich RH. Analysis of in vivo mutation induced by N-ethyl-N-nitrosourea in the hprt gene of rat lymphocytes. Environmental and Molecular Mutagenesis. 26: 261-9. PMID 8575415 DOI: 10.1002/Em.2850260402 |
0.459 |
|
| 1995 |
Beland FA, Fullerton NF, Smith BA, Heflich RH. Formation of DNA adducts and induction of mutations in rats treated with tumorigenic doses of 1,6-dinitropyrene. Environmental Health Perspectives. 185-9. PMID 7889845 DOI: 10.1289/Ehp.94102S6185 |
0.388 |
|
| 1995 |
Valentine CR, Heflich RH. Genomic DNA sequencing of mRNA splicing mutants in the hprt gene of Chinese hamster ovary cells. Environmental and Molecular Mutagenesis. 25: 85-96. PMID 7698111 DOI: 10.1002/Em.2850250202 |
0.416 |
|
| 1994 |
Mittelstaedt RA, Heflich RH. Analysis of in vivo mutation in exon 8 of the rat hprt gene. Mutation Research. 311: 139-48. PMID 7526167 DOI: 10.1016/0027-5107(94)90082-5 |
0.453 |
|
| 1994 |
Heflich RH, Neft RE. Genetic toxicity of 2-acetylaminofluorene, 2-aminofluorene and some of their metabolites and model metabolites. Mutation Research. 318: 73-114. PMID 7521935 DOI: 10.1016/0165-1110(94)90025-6 |
0.371 |
|
| 1994 |
Manjanatha MG, Lindsey LA, Mittelstaedt RA, Heflich RH. Low hprt mRNA levels and multiple hprt mRNA species in 6-thioguanine-resistant Chinese hamster cell mutants possessing nonsense mutations. Mutation Research. 308: 65-75. PMID 7516487 DOI: 10.1016/0027-5107(94)90199-6 |
0.384 |
|
| 1993 |
Manjanatha MG, Newton RK, Mittelstaedt RA, Villani GR, Declos KB, Heflich RH. Molecular analysis of DNA adducts and hprt mutations produced by 6-nitrosochrysene in Chinese hamster ovary cells. Carcinogenesis. 14: 1863-70. PMID 8403211 DOI: 10.1093/Carcin/14.9.1863 |
0.431 |
|
| 1993 |
Smith BA, Fullerton NF, Aidoo A, Heflich RH, Beland FA. DNA adduct formation in relation to lymphocyte mutations and lung tumor induction in F344 rats treated with the environmental pollutant 1,6-dinitropyrene. Environmental Health Perspectives. 99: 277-80. PMID 8319643 DOI: 10.1289/Ehp.9399277 |
0.384 |
|
| 1993 |
Li EE, Heflich RH, Delclos KB. Trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene is metabolized to form a major adduct with deoxyguanosine and produces mutations in the hprt gene of Chinese hamster ovary cells at G:C basepairs. Carcinogenesis. 14: 2109-14. PMID 8222062 DOI: 10.1093/Carcin/14.10.2109 |
0.405 |
|
| 1993 |
Aidoo A, Lyn-Cook LE, Heflich RH, George EO, Casciano DA. The effect of time after treatment, treatment schedule and animal age on the frequency of 6-thioguanine-resistant T-lymphocytes induced in Fischer 344 rats by N-ethyl-N-nitrosourea. Mutation Research. 298: 169-78. PMID 7678151 DOI: 10.1016/0165-1218(93)90038-F |
0.345 |
|
| 1992 |
Thornton-Manning JR, Smith BA, Beland FA, Heflich RH. S9-mediated metabolism of 1-nitropyrene to a mutagen in Chinese hamster ovary cells by ring-oxidation under aerobic conditions and by nitroreduction under anaerobic conditions. Carcinogenesis. 12: 2317-23. PMID 1747934 DOI: 10.1093/Carcin/12.12.2317 |
0.301 |
|
| 1992 |
Gao N, Aidoo A, Heflich RH. Analysis of rat lymphocyte activation of benzo[a]pyrene, 2-acetylaminofluorene, and several of their metabolites to mutagenic and DNA-damaging species in vitro. Teratogenesis, Carcinogenesis, and Mutagenesis. 11: 65-76. PMID 1686675 DOI: 10.1002/Tcm.1770110202 |
0.372 |
|
| 1992 |
Newton RK, Mittelstaedt RA, Manjanatha MG, Heflich RH. DNA sequence analysis of 1-nitrosopyrene-induced mutations in the hprt gene of Chinese hamster ovary cells. Carcinogenesis. 13: 819-25. PMID 1586993 DOI: 10.1093/Carcin/13.5.819 |
0.44 |
|
| 1992 |
Pothuluri JV, Heflich RH, Fu PP, Cerniglia CE. Fungal metabolism and detoxification of fluoranthene. Applied and Environmental Microbiology. 58: 937-41. PMID 1575497 DOI: 10.1128/Aem.58.3.937-941.1992 |
0.31 |
|
| 1992 |
Newton RK, Mittelstaedt RA, Heflich RH. Analysis of solvent control and 1-nitrosopyrene-induced Chinese hamster ovary cell mutants by Southern and northern blots and the polymerase chain reaction. Environmental and Molecular Mutagenesis. 19: 147-55. PMID 1541256 DOI: 10.1002/Em.2850190209 |
0.396 |
|
| 1992 |
Beland FA, Smith BA, Thornton-Manning JR, Heflich RH. Metabolic activation of 1-nitropyrene to a mammalian cell mutagen and a carcinogen. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 22: 1121-33. PMID 1441603 DOI: 10.3109/00498259209051866 |
0.354 |
|
| 1992 |
Delclos KB, Heflich RH. Mutation induction and DNA adduct formation in Chinese hamster ovary cells treated with 6-nitrochrysene, 6-aminochrysene and their metabolites. Mutation Research. 279: 153-64. PMID 1377330 DOI: 10.1016/0165-1218(92)90062-5 |
0.405 |
|
| 1991 |
Fu PP, Jung H, Von Tungeln LS, Heflich RH. Mutagenicity of mononitrodihydrobenzo[a]pyrenes. Mutation Research. 245: 277-85. PMID 2266979 DOI: 10.1016/0165-7992(90)90157-F |
0.346 |
|
| 1991 |
Aidoo A, Lyn-Cook LE, Mittelstaedt RA, Heflich RH, Casciano DA. Induction of 6-thioguanine-resistant lymphocytes in Fischer 344 rats following in vivo exposure to N-ethyl-N-nitrosourea and cyclophosphamide. Environmental and Molecular Mutagenesis. 17: 141-51. PMID 2022192 DOI: 10.1002/Em.2850170302 |
0.399 |
|
| 1991 |
Aidoo A, Gao N, Neft RE, Schol HM, Hass BS, Minor TY, Heflich RH. Evaluation of the genotoxicity of gentian violet in bacterial and mammalian cell systems. Teratogenesis, Carcinogenesis, and Mutagenesis. 10: 449-62. PMID 1982909 DOI: 10.1002/Tcm.1770100604 |
0.395 |
|
| 1991 |
Yu SY, Heflich RH, Von Tungeln LS, el-Bayoumy K, Kadlubar FF, Fu PP. Comparative direct-acting mutagenicity of 1- and 2-nitropyrene: evidence for 2-nitropyrene mutagenesis by both guanine and adenine adducts. Mutation Research. 250: 145-52. PMID 1944329 DOI: 10.1016/0027-5107(91)90170-S |
0.377 |
|
| 1991 |
Thornton-Manning JR, Smith BA, Beland FA, Heflich RH. Mutagenesis and DNA adduct formation by 1-nitropyrene in Chinese hamster ovary cells without exogenous metabolic activation. Toxicology and Applied Pharmacology. 109: 538-46. PMID 1853350 DOI: 10.1016/0041-008X(91)90016-8 |
0.38 |
|
| 1990 |
Yerokun T, Hein DW, Ferguson RJ, Ogolla F, Heflich RH, Minor TY, Trinidad A, Kirlin WG, Andrews AF. Relationship of syrian inbred hamster acetylator genotype to the mutagenic activation of 2-aminofluorene Mutagenesis. 5: 233-240. PMID 2385177 DOI: 10.1093/Mutage/5.3.233 |
0.315 |
|
| 1990 |
Heflich RH, Thornton-Manning JR, Kinouchi T, Beland FA. Mutagenicity of oxidized microsomal metabolites of 1-nitropyrene in Chinese hamster ovary cells. Mutagenesis. 5: 151-7. PMID 2188067 DOI: 10.1093/Mutage/5.2.151 |
0.333 |
|
| 1989 |
McMillan DC, Shaddock JG, Heflich RH, Casciano DA, Hinson JA. Evaluation of propanil and its N-oxidized derivatives for genotoxicity in the Salmonella typhimurium reversion, Chinese hamster ovary/hypoxanthine guanine phosphoribosyl transferase, and rat hepatocyte/DNA repair assays. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 11: 429-39. PMID 3065118 DOI: 10.1093/Toxsci/11.1.429 |
0.37 |
|
| 1989 |
Shaddock JG, Heflich RH, McMillan DC, Hinson JA, Casciano DA. Pretreatment with mixed-function oxidase inducers increases the sensitivity of the hepatocyte/DNA repair assay. Environmental and Molecular Mutagenesis. 13: 281-8. PMID 2737181 DOI: 10.1002/Em.2850130402 |
0.367 |
|
| 1989 |
el-Bayoumy K, Delclos KB, Heflich RH, Walker R, Shiue GH, Hecht SS. Mutagenicity, metabolism and DNA adduct formation of 6-nitrochrysene in Salmonella typhimurium. Mutagenesis. 4: 235-40. PMID 2659942 DOI: 10.1093/Mutage/4.3.235 |
0.354 |
|
| 1989 |
Thornton-Manning JR, Campbell WL, Hass BS, Chen JJ, Fu PP, Cerniglia CE, Heflich RH. Role of nitroreduction in the synergistic mutational response induced by mixtures of 1- and 3-nitrobenzo[a]pyrene in Salmonella typhimurium Environmental and Molecular Mutagenesis. 13: 203-210. PMID 2651117 DOI: 10.1002/Em.2850130303 |
0.368 |
|
| 1988 |
Heflich RH, Djurić Z, Zhuo Z, Fullerton NF, Casciano DA, Beland FA. Metabolism of 2-acetylaminofluorene in the Chinese hamster ovary cell mutation assay. Environmental and Molecular Mutagenesis. 11: 167-81. PMID 3345736 DOI: 10.1002/Em.2850110203 |
0.344 |
|
| 1988 |
Li AP, Gupta RS, Heflich RH, Wassom JS. A review and analysis of the Chinese hamster ovary/hypoxanthine guanine phosphoribosyl transferase assay to determine the mutagenicity of chemical agents. A report of phase III of the U.S. Environmental Protection Agency Gene-Tox Program. Mutation Research. 196: 17-36. PMID 3292898 DOI: 10.1016/0165-1110(88)90026-7 |
0.305 |
|
| 1988 |
Fu PP, Heflich RH, Von Tungeln LS, Miranda HZ, Evans FE. Microsomal metabolism of 1-nitrobenzo[e]pyrene to a highly mutagenic K-region dihydrodiol. Carcinogenesis. 9: 951-8. PMID 3286032 DOI: 10.1093/Carcin/9.6.951 |
0.306 |
|
| 1988 |
Thornton-Manning JR, Chou MW, Fu PP, Heflich RH. Microsomal activation of 1- and 3-nitrobenzo[a]pyrene to mutagens in Chinese hamster ovary cells. Mutagenesis. 3: 233-7. PMID 3045485 DOI: 10.1093/Mutage/3.3.233 |
0.349 |
|
| 1988 |
Cerniglia CE, Lambert KJ, White GL, Heflich RH, Franklin W, Fifer EK, Beland FA. Metabolism of 1,8-dinitropyrene by human, rhesus monkey, and rat intestinal microflora Toxicity Assessment. 3: 147-159. DOI: 10.1002/Tox.2540030206 |
0.307 |
|
| 1987 |
Hass BS, Chen JJ, Chou MW, Fu PP, Heflich RH. Binary mixtures containing isomers of nitrobenzo[a]pyrene induce greater-than-additive mutational responses in Salmonella typhimurium. I. Analysis by the total concentration-proportional mixture model. Mutation Research. 190: 247-52. PMID 3550451 DOI: 10.1016/0165-7992(87)90004-2 |
0.359 |
|
| 1987 |
Ni YC, Heflich RH, Kadlubar FF, Fu PP. Mutagenicity of nitrofurans in Salmonella typhimurium TA98, TA98NR and TA98/1,8-DNP6. Mutation Research. 192: 15-22. PMID 3309641 DOI: 10.1016/0165-7992(87)90120-5 |
0.309 |
|
| 1986 |
Chou MW, Heflich RH, Fu PP. Metabolism of 1-nitrobenzo[a]pyrene by rat liver microsomes to potent mutagenic metabolites. Carcinogenesis. 7: 1837-44. PMID 3769131 DOI: 10.1093/Carcin/7.11.1837 |
0.312 |
|
| 1986 |
Heflich RH, Fullerton NF, Beland FA. An examination of the weak mutagenic response of 1-nitropyrene in Chinese hamster ovary cells. Mutation Research. 161: 99-108. PMID 3702899 DOI: 10.1016/0027-5107(86)90104-1 |
0.429 |
|
| 1986 |
Hass BS, Heflich RH, Schol HM, Chou MW, Fu PP, Casciano DA. Mutagenicity of the mononitrobenzo[a]pyrenes in Chinese hamster ovary cells mediated by rat hepatocytes or liver S9. Carcinogenesis. 7: 681-4. PMID 3698200 DOI: 10.1093/Carcin/7.4.681 |
0.334 |
|
| 1986 |
Hass BS, Heflich RH, Chou MW, White GL, Fu PP, Casciano DA. Hepatocyte-mediated mutagenicity of mononitrobenzo[a]pyrenes in Salmonella typhimurium strains. Mutation Research. 171: 123-9. PMID 3528834 DOI: 10.1016/0165-1218(86)90044-3 |
0.334 |
|
| 1986 |
Heflich RH, Morris SM, Beranek DT, McGarrity LJ, Chen JJ, Beland FA. Relationships between the DNA adducts and the mutations and sister-chromatid exchanges produced in Chinese hamster ovary cells by N-hydroxy-2-aminofluorene, N-hydroxy-N'-acetylbenzidine and 1-nitrosopyrene. Mutagenesis. 1: 201-6. PMID 3331660 DOI: 10.1093/Mutage/1.3.201 |
0.404 |
|
| 1986 |
Djurić Z, Potter DW, Heflich RH, Beland FA. Aerobic and anaerobic reduction of nitrated pyrenes in vitro. Chemico-Biological Interactions. 59: 309-24. PMID 3021349 DOI: 10.1016/S0009-2797(86)80076-X |
0.347 |
|
| 1986 |
Zhuo Z, Casciano DA, Heflich RH. Use of the human liver cell line Hep G2 in a modified Salmonella reversion assay. Cancer Letters. 32: 327-34. PMID 3021322 DOI: 10.1016/0304-3835(86)90186-2 |
0.313 |
|
| 1985 |
Heflich RH, Morris SM, White GL, Beland FA. The differential effect of benzamide upon the toxicity and mutations produced in Chinese hamster ovary cells by N-methyl nitrosourea, N-ethyl nitrosourea and N-hydroxy-2-aminofluorene Mutation Research Letters. 142: 203-207. PMID 4039030 DOI: 10.1016/0165-7992(85)90024-7 |
0.321 |
|
| 1985 |
Heflich RH, Fifer EK, Djuric Z, Beland FA. DNA adduct formation and mutation induction by nitropyrenes in Salmonella and Chinese hamster ovary cells: Relationships with nitroreduction and acetylation Environmental Health Perspectives. 135-143. PMID 3910415 DOI: 10.1289/Ehp.8562135 |
0.449 |
|
| 1985 |
Cerniglia CE, White GL, Heflich RH. Fungal metabolism and detoxification of polycyclic aromatic hydrocarbons Archives of Microbiology. 143: 105-110. PMID 3907570 DOI: 10.1007/Bf00411031 |
0.303 |
|
| 1985 |
Hass BS, Heflich RH, Shaddock JG, Casciano DA. Comparison of mutagenicities in a Salmonella reversion assay mediated by uninduced hepatocytes and hepatocytes from rats pretreated for 1 or 5 days with Aroclor 1254. Environmental Mutagenesis. 7: 391-403. PMID 3899628 DOI: 10.1002/Em.2860070313 |
0.322 |
|
| 1985 |
Heflich RH, Howard PC, Beland FA. 1-Nitrosopyrene: an intermediate in the metabolic activation of 1-nitropyrene to a mutagen in Salmonella typhimurium TA1538. Mutation Research. 149: 25-32. PMID 3883150 DOI: 10.1016/0027-5107(85)90005-3 |
0.374 |
|
| 1984 |
Beland FA, Fullerton NF, Heflich RH. Rapid isolation, hydrolysis and chromatography of formaldehyde-modified DNA Journal of Chromatography B: Biomedical Sciences and Applications. 308: 121-131. DOI: 10.1016/S0021-9673(01)87539-7 |
0.325 |
|
| 1983 |
Beranek DT, Heflich RH, Kodell RL, Morris SM, Casciano DA. Correlation between specific DNA-methylation products and mutation induction at the HGPRT locus in Chinese hamster ovary cells Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 110: 171-180. PMID 6865996 DOI: 10.1016/0027-5107(83)90026-X |
0.378 |
|
| 1983 |
Morris SM, Beranek DT, Heflich RH. The relationship between sister-chromatid exchange induction and the formation of specific methylated DNA adducts in Chinese hamster ovary cells Mutation Research Letters. 121: 261-266. PMID 6621589 DOI: 10.1016/0165-7992(83)90212-9 |
0.344 |
|
| 1983 |
White GL, Beranek DT, Heflich RH. Effect of bacterial concentration on reversions induced in Salmonella typhimurium TA1538 by N-hydroxy-2-acetylaminofluorene Environmental Mutagenesis. 5: 565-575. PMID 6347679 DOI: 10.1002/Em.2860050406 |
0.322 |
|
| 1983 |
Beland FA, Beranek DT, Dooley KL, Heflich RH, Kadlubar FF. Arylamine-DNA adducts in vitro and in vivo: their role in bacterial mutagenesis and urinary bladder carcinogenesis. Environmental Health Perspectives. 49: 125-34. PMID 6339219 DOI: 10.1289/Ehp.8349125 |
0.346 |
|
| 1982 |
Morris SM, Heflich RH, Beranek DT, Kodell RL. Alkylation-induced sister-chromatic exchanges correlate with reduced cell survival, not mutations Mutation Research Letters. 105: 163-168. PMID 7144786 DOI: 10.1016/0165-7992(82)90006-9 |
0.362 |
|
| 1982 |
Miller JH, Heflich RH. A model for the effect of excision repair on the survival of human cells exposed to chemical carcinogens Chemico-Biological Interactions. 39: 45-55. PMID 7060220 DOI: 10.1016/0009-2797(82)90005-9 |
0.317 |
|
| 1982 |
Heflich RH, Beranek DT, Kodell RL, Morris SM. Induction of mutations and sister-chromatid exchanges in Chinese hamster ovary cells by ethylating agents Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 106: 147-161. PMID 6891748 DOI: 10.1016/0027-5107(82)90198-1 |
0.397 |
|
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