Lutz Birnbaumer - Publications

Affiliations: 
1971-1974 Northwestern University, Evanston, IL 
 1975-1994 Baylor College of Medicine, Houston, TX 
 1994-2001 University of California, Los Angeles, Los Angeles, CA 
 2001-2013 National Institute of Environmental Health Sciences (NIEHS), Durham, NC, United States 
Website:
https://www.niehs.nih.gov/news/newsroom/releases/2001/july09/index.cfm

273 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Malkmus K, Brosien M, Knoepp F, Schaffelhofer L, Grimminger F, Rummel C, Gudermann T, Dietrich A, Birnbaumer L, Weissmann N, Kraut S. Deletion of classical transient receptor potential 1, 3 and 6 alters pulmonary vasoconstriction in chronic hypoxia-induced pulmonary hypertension in mice. Frontiers in Physiology. 13: 1080875. PMID 36569761 DOI: 10.3389/fphys.2022.1080875  0.592
2022 Tian JB, Yang J, Joslin WC, Flockerzi V, Prescott SA, Birnbaumer L, Zhu MX. TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect G-G coincidence signals of variable strengths. Proceedings of the National Academy of Sciences of the United States of America. 119: e2120870119. PMID 35544691 DOI: 10.1073/pnas.2120870119  0.494
2020 Jeon J, Bu F, Sun G, Tian JB, Ting SM, Li J, Aronowski J, Birnbaumer L, Freichel M, Zhu MX. Contribution of TRPC Channels in Neuronal Excitotoxicity Associated With Neurodegenerative Disease and Ischemic Stroke. Frontiers in Cell and Developmental Biology. 8: 618663. PMID 33490083 DOI: 10.3389/fcell.2020.618663  0.698
2020 Murtaza B, Hichami A, Khan AS, Plesnik J, Sery O, Dietrich A, Birnbaumer L, Khan NA. Implication of TRPC3 Channel in Gustatory Perception of Dietary Lipids. Acta Physiologica (Oxford, England). PMID 32882106 DOI: 10.1111/Apha.13554  0.525
2020 Camacho Londoño JE, Kuryshev V, Zorn M, Saar K, Tian Q, Hübner N, Nawroth P, Dietrich A, Birnbaumer L, Lipp P, Dieterich C, Freichel M. Transcriptional signatures regulated by TRPC1/C4-mediated Background Ca entry after pressure-overload induced cardiac remodelling. Progress in Biophysics and Molecular Biology. PMID 32738354 DOI: 10.1016/J.Pbiomolbio.2020.07.006  0.494
2020 Anderson A, Masuho I, Marron Fernandez de Velasco E, Nakano A, Birnbaumer L, Martemyanov KA, Wickman K. GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 32513692 DOI: 10.1073/Pnas.2001270117  0.372
2020 Formoso K, Susperreguy S, Freichel M, Birnbaumer L. RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways. Scientific Reports. 10: 7227. PMID 32350291 DOI: 10.1038/s41598-020-61177-x  0.361
2020 Tsvilovskyy V, Solis-Lopez A, Almering J, Richter C, Birnbaumer L, Dietrich A, Freichel M. Analysis of Mrgprb2 Receptor-Evoked Ca Signaling in Bone Marrow Derived (BMMC) and Peritoneal (PMC) Mast Cells of TRPC-Deficient Mice. Frontiers in Immunology. 11: 564. PMID 32322252 DOI: 10.3389/Fimmu.2020.00564  0.596
2020 Camacho Londoño JE, Marx A, Kraft AE, Schürger A, Richter C, Dietrich A, Lipp P, Birnbaumer L, Freichel M. Angiotensin-II-Evoked Ca Entry in Murine Cardiac Fibroblasts Does Not Depend on TRPC Channels. Cells. 9. PMID 32013125 DOI: 10.3390/Cells9020322  0.537
2019 Tomilin VN, Mamenko M, Zaika O, Ren G, Marrelli SP, Birnbaumer L, Pochynyuk O. TRPC3 determines osmosensitive [Ca2+]i signaling in the collecting duct and contributes to urinary concentration. Plos One. 14: e0226381. PMID 31851715 DOI: 10.1371/journal.pone.0226381  0.3
2019 Greenberg HZE, Carlton-Carew SRE, Zargaran AK, Jahan KS, Birnbaumer L, Albert AP. Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced relaxations and nitric oxide production in mesenteric arteries: comparative study using wild-type and TRPC1 mice. Channels (Austin, Tex.). 1-14. PMID 31603369 DOI: 10.1080/19336950.2019.1673131  0.413
2019 Farmer LK, Rollason R, Whitcomb DJ, Ni L, Goodliff A, Lay AC, Birnbaumer L, Heesom KJ, Xu SZ, Saleem MA, Welsh GI. TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility. Journal of the American Society of Nephrology : Jasn. PMID 31416818 DOI: 10.1681/ASN.2018070729  0.383
2019 Numaga-Tomita T, Shimauchi T, Oda S, Tanaka T, Nishiyama K, Nishimura A, Birnbaumer L, Mori Y, Nishida M. TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802811R. PMID 31162976 DOI: 10.1096/fj.201802811R  0.366
2019 Egorov AV, Schumacher D, Medert R, Birnbaumer L, Freichel M, Draguhn A. TRPC channels are not required for graded persistent activity in entorhinal cortex neurons. Hippocampus. PMID 31002217 DOI: 10.1002/Hipo.23094  0.374
2019 Tiapko O, Shrestha N, Lindinger S, Guedes de la Cruz G, Graziani A, Klec C, Butorac C, Graier WF, Kubista H, Freichel M, Birnbaumer L, Romanin C, Glasnov T, Groschner K. Lipid-independent control of endothelial and neuronal TRPC3 channels by light. Chemical Science. 10: 2837-2842. PMID 30997005 DOI: 10.1039/c8sc05536j  0.34
2019 Ibeh CL, Yiu AJ, Kanaras YL, Paal E, Birnbaumer L, Jose PA, Bandyopadhyay BC. Evidence for a regulated Ca entry in proximal tubular cells and its implication in calcium stone formation. Journal of Cell Science. PMID 30910829 DOI: 10.1242/Jcs.225268  0.347
2018 Saliba Y, Jebara V, Hajal J, Maroun R, Chacar S, Smayra V, Abramowitz J, Birnbaumer L, Fares N. Transient Receptor Potential Canonical 3 and Nuclear Factor of Activated T-cells C3 Signaling Pathway Critically Regulates Myocardial Fibrosis. Antioxidants & Redox Signaling. PMID 30318928 DOI: 10.1089/ars.2018.7545  0.332
2018 Cao H, Qadri SM, Lang E, Pelzl L, Umbach AT, Leiss V, Birnbaumer L, Nürnberg B, Pieske B, Voelkl J, Gawaz M, Bissinger R, Lang F. Heterotrimeric G-protein subunit Gα contributes to agonist-sensitive apoptosis and degranulation in murine platelets. Physiological Reports. 6: e13841. PMID 30187671 DOI: 10.14814/phy2.13841  0.315
2018 Ilatovskaya DV, Blass G, Palygin O, Levchenko V, Pavlov TS, Grzybowski MN, Winsor K, Shuyskiy LS, Geurts AM, Cowley AW, Birnbaumer L, Staruschenko A. A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease. Journal of the American Society of Nephrology : Jasn. PMID 29793963 DOI: 10.1681/Asn.2018030280  0.304
2018 Nobles M, Montaigne D, Sebastian S, Birnbaumer L, Tinker A. Differential effects of inhibitory G-protein isoforms on G-protein gated inwardly rectifying K+ currents in adult murine atria. American Journal of Physiology. Cell Physiology. PMID 29342363 DOI: 10.1152/ajpcell.00271.2016  0.392
2017 Dube PR, Chikkamenahalli LL, Birnbaumer L, Vazquez G. Reduced calcification and osteogenic features in advanced atherosclerotic plaques of mice with macrophage-specific loss of TRPC3. Atherosclerosis. PMID 29290366 DOI: 10.1016/j.atherosclerosis.2017.12.025  0.364
2017 Chaudhuri P, Rosenbaum MA, Birnbaumer L, Graham LM. Integration of TRPC6 and NADPH Oxidase Activation in Lysophosphatidylcholine-induced TRPC5 Externalization. American Journal of Physiology. Cell Physiology. ajpcell.00028.2017. PMID 28835433 DOI: 10.1152/ajpcell.00028.2017  0.328
2017 Li W, Ding Y, Smedley C, Wang Y, Chaudhari S, Birnbaumer L, Ma R. Increased glomerular filtration rate and impaired contractile function of mesangial cells in TRPC6 knockout mice. Scientific Reports. 7: 4145. PMID 28646178 DOI: 10.1038/s41598-017-04067-z  0.368
2017 Belkacemi T, Niermann A, Hofmann L, Wissenbach U, Birnbaumer L, Leidinger P, Backes C, Meese E, Keller A, Bai X, Scheller A, Kirchhoff F, Philipp SE, Weissgerber P, Flockerzi V, et al. TRPC1- and TRPC3-dependent Ca(2+) signaling in mouse cortical astrocytes affects injury-evoked astrogliosis in vivo. Glia. PMID 28636132 DOI: 10.1002/Glia.23180  0.365
2017 He X, Li S, Liu B, Susperreguy S, Formoso K, Yao J, Kang J, Shi A, Birnbaumer L, Liao Y. Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries. Proceedings of the National Academy of Sciences of the United States of America. PMID 28526717 DOI: 10.1073/Pnas.1621384114  0.325
2017 Shi J, Miralles F, Kinet JP, Birnbaumer L, Large WA, Albert AP. Evidence that Orai1 does not contribute to store-operated TRPC1 channels in vascular smooth muscle cells. Channels (Austin, Tex.). 0. PMID 28301277 DOI: 10.1080/19336950.2017.1303025  0.446
2017 Danielczok J, Hertz L, Ruppenthal S, Kaiser E, Petkova-Kirova P, Bogdanova A, Krause E, Lipp P, Freichel M, Kaestner L, Birnbaumer L. Does Erythropoietin Regulate TRPC Channels in Red Blood Cells? Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 41: 1219-1228. PMID 28268218 DOI: 10.1159/000464384  0.412
2017 Yamaguchi Y, Iribe G, Kaneko T, Takahashi K, Numaga-Tomita T, Nishida M, Birnbaumer L, Naruse K. TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca(2+) concentration in mouse cardiomyocytes. The Journal of Physiological Sciences : Jps. PMID 28105583 DOI: 10.1007/s12576-016-0519-3  0.398
2017 Dalton G, An SW, Al-Juboori SI, Nischan N, Yoon J, Dobrinskikh E, Hilgemann DW, Xie J, Luby-Phelps K, Kohler JJ, Birnbaumer L, Huang CL. Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 28069944 DOI: 10.1073/Pnas.1620301114  0.305
2016 Phelan KD, Shwe UT, Cozart MA, Wu H, Mock MM, Abramowitz J, Birnbaumer L, Zheng F. TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice. Epilepsia. PMID 28012173 DOI: 10.1111/epi.13648  0.371
2016 Wu YL, Xie J, An SW, Oliver N, Barrezueta NX, Lin MH, Birnbaumer L, Huang CL. Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho. Kidney International. PMID 27979597 DOI: 10.1016/j.kint.2016.09.039  0.31
2016 Shi J, Miralles F, Birnbaumer L, Large WA, Albert AP. Store-operated STIM1 translocation and interaction with TRPC1 at the plasma membrane stimulates PLC activity to induce channel gating in vascular smooth muscle cells. The Journal of Physiology. PMID 27753095 DOI: 10.1113/JP273302  0.429
2016 Han JW, Lee YH, Yoen SI, Abramowitz J, Birnbaumer L, Lee MG, Kim JY. Resistance to pathologic cardiac hypertrophy and reduced expression of CaV1.2 in Trpc3-depleted mice. Molecular and Cellular Biochemistry. PMID 27522668 DOI: 10.1007/s11010-016-2784-0  0.373
2016 Bissinger R, Lang E, Ghashghaeinia M, Singh Y, Zelenak C, Fehrenbacher B, Honisch S, Chen H, Fakhri H, Umbach AT, Liu G, Rexhepaj R, Liu G, Schaller M, Mack AF, ... ... Birnbaumer L, et al. Blunted apoptosis of erythrocytes in mice deficient in the heterotrimeric G-protein subunit Gαi2. Scientific Reports. 6: 30925. PMID 27499046 DOI: 10.1038/Srep30925  0.38
2016 Xu Y, Orlandi C, Cao Y, Yang S, Choi CI, Pagadala V, Birnbaumer L, Martemyanov KA, Vardi N. The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go. Scientific Reports. 6: 20940. PMID 26883481 DOI: 10.1038/Srep20940  0.41
2016 Chaudhuri P, Rosenbaum MA, Sinharoy P, Damron DS, Birnbaumer L, Graham LM. Membrane translocation of TRPC6 channels and endothelial migration are regulated by calmodulin and PI3 kinase activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 26858457 DOI: 10.1073/pnas.1600371113  0.406
2015 Riazanski V, Gabdoulkhakova AG, Boynton LS, Eguchi RR, Deriy LV, Hogarth DK, Loaëc N, Oumata N, Galons H, Brown ME, Shevchenko P, Gallan AJ, Yoo SG, Naren AP, Villereal ML, ... ... Birnbaumer L, et al. TRPC6 channel translocation into phagosomal membrane augments phagosomal function. Proceedings of the National Academy of Sciences of the United States of America. 112: E6486-95. PMID 26604306 DOI: 10.1073/Pnas.1518966112  0.385
2015 Sexton JE, Desmonds T, Quick K, Taylor R, Abramowitz J, Forge A, Kros CJ, Birnbaumer L, Wood JN. The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing. Neuroscience Letters. 610: 36-42. PMID 26520460 DOI: 10.1016/j.neulet.2015.10.052  0.371
2015 Shi J, Miralles F, Birnbaumer L, Large WA, Albert AP. Store depletion induces Gαq-mediated PLCβ1 activity to stimulate TRPC1 channels in vascular smooth muscle cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26467792 DOI: 10.1096/fj.15-280271  0.413
2015 Birnbaumer L. From GTP and G proteins to TRPC channels: a personal account. Journal of Molecular Medicine (Berlin, Germany). 93: 941-53. PMID 26377676 DOI: 10.1007/s00109-015-1328-5  0.34
2015 Villanueva H, Visbal AP, Obeid NF, Ta AQ, Faruki AA, Wu MF, Hilsenbeck SG, Shaw CA, Yu P, Plummer NW, Birnbaumer L, Lewis MT. An essential role for Gαi2 in Smoothened-stimulated epithelial cell proliferation in the mammary gland. Science Signaling. 8: ra92. PMID 26373672 DOI: 10.1126/Scisignal.Aaa7355  0.385
2015 Camacho Londoño JE, Tian Q, Hammer K, Schröder L, Camacho Londoño J, Reil JC, He T, Oberhofer M, Mannebach S, Mathar I, Philipp SE, Tabellion W, Schweda F, Dietrich A, Kaestner L, ... ... Birnbaumer L, et al. A background Ca2+ entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling. European Heart Journal. PMID 26069213 DOI: 10.1093/Eurheartj/Ehv250  0.559
2015 Zhou X, Ye Y, Sun Y, Li X, Wang W, Privratsky B, Tan S, Zhou Z, Huang C, Wei YQ, Birnbaumer L, Singh BB, Wu M. Transient Receptor Potential Channel 1 Deficiency Impairs Host Defense and Proinflammatory Responses to Bacterial Infection by Regulating Protein Kinase Cα Signaling. Molecular and Cellular Biology. 35: 2729-39. PMID 26031335 DOI: 10.1128/Mcb.00256-15  0.301
2015 Sun Y, Birnbaumer L, Singh BB. TRPC1 Regulates Calcium-Activated Chloride Channels in Salivary Gland Cells. Journal of Cellular Physiology. PMID 25899321 DOI: 10.1002/Jcp.25017  0.324
2015 Smedlund KB, Birnbaumer L, Vazquez G. Increased size and cellularity of advanced atherosclerotic lesions in mice with endothelial overexpression of the human TRPC3 channel. Proceedings of the National Academy of Sciences of the United States of America. 112: E2201-6. PMID 25870279 DOI: 10.1073/pnas.1505410112  0.313
2015 Li X, Wang D, Chen Z, Lu E, Wang Z, Duan J, Tian W, Wang Y, You L, Zou Y, Cheng Y, Zhu Q, Wan X, Xi T, Birnbaumer L, et al. Gαi1 and Gαi3 regulate macrophage polarization by forming a complex containing CD14 and Gab1. Proceedings of the National Academy of Sciences of the United States of America. 112: 4731-6. PMID 25825741 DOI: 10.1073/pnas.1503779112  0.318
2014 Domes K, Patrucco E, Loga F, Dietrich A, Birnbaumer L, Wegener JW, Hofmann F. Murine cardiac growth, TRPC channels, and cGMP kinase I. Pflugers Archiv : European Journal of Physiology. PMID 25547873 DOI: 10.1007/S00424-014-1682-0  0.558
2014 Saliba Y, Karam R, Smayra V, Aftimos G, Abramowitz J, Birnbaumer L, Farès N. Evidence of a Role for Fibroblast Transient Receptor Potential Canonical 3 Ca2+ Channel in Renal Fibrosis. Journal of the American Society of Nephrology : Jasn. PMID 25479966 DOI: 10.1681/ASN.2014010065  0.383
2014 Kochukov MY, Balasubramanian A, Abramowitz J, Birnbaumer L, Marrelli SP. Activation of endothelial transient receptor potential C3 channel is required for small conductance calcium-activated potassium channel activation and sustained endothelial hyperpolarization and vasodilation of cerebral artery. Journal of the American Heart Association. 3. PMID 25142058 DOI: 10.1161/JAHA.114.000913  0.441
2014 Du J, Ma X, Shen B, Huang Y, Birnbaumer L, Yao X. TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 4677-85. PMID 25114176 DOI: 10.1096/Fj.14-251652  0.405
2014 Phelan KD, Shwe UT, Abramowitz J, Birnbaumer L, Zheng F. Critical role of canonical transient receptor potential channel 7 in initiation of seizures. Proceedings of the National Academy of Sciences of the United States of America. 111: 11533-8. PMID 25049394 DOI: 10.1073/pnas.1411442111  0.367
2014 Solanki S, Dube PR, Tano JY, Birnbaumer L, Vazquez G. Reduced endoplasmic reticulum stress-induced apoptosis and impaired unfolded protein response in TRPC3-deficient M1 macrophages. American Journal of Physiology. Cell Physiology. 307: C521-31. PMID 25031020 DOI: 10.1152/ajpcell.00369.2013  0.306
2014 Liao Y, Abramowitz J, Birnbaumer L. The TRPC family of TRP channels: roles inferred (mostly) from knockout mice and relationship to ORAI proteins. Handbook of Experimental Pharmacology. 223: 1055-75. PMID 24961980 DOI: 10.1007/978-3-319-05161-1_14  0.438
2014 Wang Z, Dela Cruz R, Ji F, Guo S, Zhang J, Wang Y, Feng GS, Birnbaumer L, Jiang M, Chu WM. G(i)α proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells. Cell Communication and Signaling : Ccs. 12: 10. PMID 24521094 DOI: 10.1186/1478-811X-12-10  0.311
2014 Seo K, Rainer PP, Shalkey Hahn V, Lee DI, Jo SH, Andersen A, Liu T, Xu X, Willette RN, Lepore JJ, Marino JP, Birnbaumer L, Schnackenberg CG, Kass DA. Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy. Proceedings of the National Academy of Sciences of the United States of America. 111: 1551-6. PMID 24453217 DOI: 10.1073/pnas.1308963111  0.354
2014 Seo K, Rainer PP, Lee DI, Hao S, Bedja D, Birnbaumer L, Cingolani OH, Kass DA. Hyperactive adverse mechanical stress responses in dystrophic heart are coupled to transient receptor potential canonical 6 and blocked by cGMP-protein kinase G modulation. Circulation Research. 114: 823-32. PMID 24449818 DOI: 10.1161/CIRCRESAHA.114.302614  0.377
2014 Minetti GC, Feige JN, Bombard F, Heier A, Morvan F, Nürnberg B, Leiss V, Birnbaumer L, Glass DJ, Fornaro M. Gαi2 signaling is required for skeletal muscle growth, regeneration, and satellite cell proliferation and differentiation. Molecular and Cellular Biology. 34: 619-30. PMID 24298018 DOI: 10.1128/MCB.00957-13  0.304
2014 Shi J, Birnbaumer L, Large WA, Albert AP. Myristoylated alanine-rich C kinase substrate coordinates native TRPC1 channel activation by phosphatidylinositol 4,5-bisphosphate and protein kinase C in vascular smooth muscle. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 244-55. PMID 24022404 DOI: 10.1096/fj.13-238022  0.398
2013 Pomrenze MB, Baratta MV, Rasmus KC, Cadle BA, Nakamura S, Birnbaumer L, Cooper DC. Cocaine self-administration in mice with forebrain knock-down of trpc5 ion channels. F1000research. 2: 53. PMID 24358869 DOI: 10.12688/F1000Research.2-53.V1  0.304
2013 Sekerková G, Kim JA, Nigro MJ, Becker EB, Hartmann J, Birnbaumer L, Mugnaini E, Martina M. Early onset of ataxia in moonwalker mice is accompanied by complete ablation of type II unipolar brush cells and Purkinje cell dysfunction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 19689-94. PMID 24336732 DOI: 10.1523/Jneurosci.2294-13.2013  0.364
2013 Ezan J, Lasvaux L, Gezer A, Novakovic A, May-Simera H, Belotti E, Lhoumeau AC, Birnbaumer L, Beer-Hammer S, Borg JP, Le Bivic A, Nürnberg B, Sans N, Montcouquiol M. Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton. Nature Cell Biology. 15: 1107-15. PMID 23934215 DOI: 10.1038/Ncb2819  0.331
2013 Loga F, Domes K, Freichel M, Flockerzi V, Dietrich A, Birnbaumer L, Hofmann F, Wegener JW. The role of cGMP/cGKI signalling and Trpc channels in regulation of vascular tone. Cardiovascular Research. 100: 280-7. PMID 23832809 DOI: 10.1093/Cvr/Cvt176  0.595
2013 Harper MT, Londoño JE, Quick K, Londoño JC, Flockerzi V, Philipp SE, Birnbaumer L, Freichel M, Poole AW. Transient receptor potential channels function as a coincidence signal detector mediating phosphatidylserine exposure. Science Signaling. 6: ra50. PMID 23800468 DOI: 10.1126/scisignal.2003701  0.403
2013 Feng S, Li H, Tai Y, Huang J, Su Y, Abramowitz J, Zhu MX, Birnbaumer L, Wang Y. Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake. Proceedings of the National Academy of Sciences of the United States of America. 110: 11011-6. PMID 23776229 DOI: 10.1073/Pnas.1309531110  0.582
2013 Ong EC, Nesin V, Long CL, Bai CX, Guz JL, Ivanov IP, Abramowitz J, Birnbaumer L, Humphrey MB, Tsiokas L. A TRPC1 protein-dependent pathway regulates osteoclast formation and function. The Journal of Biological Chemistry. 288: 22219-32. PMID 23770672 DOI: 10.1074/Jbc.M113.459826  0.313
2013 Dasari S, Abramowitz J, Birnbaumer L, Gulledge AT. Do canonical transient receptor potential channels mediate cholinergic excitation of cortical pyramidal neurons? Neuroreport. 24: 550-4. PMID 23652155 DOI: 10.1097/Wnr.0B013E3283621344  0.368
2013 Medic N, Desai A, Olivera A, Abramowitz J, Birnbaumer L, Beaven MA, Gilfillan AM, Metcalfe DD. Knockout of the Trpc1 gene reveals that TRPC1 can promote recovery from anaphylaxis by negatively regulating mast cell TNF-α production. Cell Calcium. 53: 315-26. PMID 23489970 DOI: 10.1016/J.Ceca.2013.02.001  0.337
2013 Wong AC, Birnbaumer L, Housley GD. Canonical transient receptor potential channel subtype 3-mediated hair cell Ca(2+) entry regulates sound transduction and auditory neurotransmission. The European Journal of Neuroscience. 37: 1478-86. PMID 23442051 DOI: 10.1111/ejn.12158  0.396
2013 Loga F, Domes K, Freichel M, Flockerzi V, Dietrich A, Birnbaumer L, Hofmann F, Wegener JW. Evidence for functional coupling of cGMP/cGKI signalling and TRPC channels in endothelium but not in vascular smooth muscle Bmc Pharmacology and Toxicology. 14. DOI: 10.1186/2050-6511-14-S1-P40  0.552
2013 Ang R, Birnbaumer L, Gourine A, Tinker A. 223 THE ROLE OF INHIBITORY G PROTEIN GALPHAO-MEDIATED SIGNALLING IN THE CENTRAL NERVOUS MECHANISMS CONTROLLING SYMPATHETIC OUTFLOW TO THE HEART Heart. 99: A121.1-A121. DOI: 10.1136/Heartjnl-2013-304019.223  0.301
2012 Plummer NW, Spicher K, Malphurs J, Akiyama H, Abramowitz J, Nürnberg B, Birnbaumer L. Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins. Proceedings of the National Academy of Sciences of the United States of America. 109: 21366-71. PMID 23236180 DOI: 10.1073/pnas.1219810110  0.309
2012 Suresh Babu S, Wojtowicz A, Freichel M, Birnbaumer L, Hecker M, Cattaruzza M. Mechanism of stretch-induced activation of the mechanotransducer zyxin in vascular cells. Science Signaling. 5: ra91. PMID 23233529 DOI: 10.1126/scisignal.2003173  0.377
2012 Xie J, Cha SK, An SW, Kuro-O M, Birnbaumer L, Huang CL. Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart. Nature Communications. 3: 1238. PMID 23212367 DOI: 10.1038/ncomms2240  0.319
2012 Tauseef M, Knezevic N, Chava KR, Smith M, Sukriti S, Gianaris N, Obukhov AG, Vogel SM, Schraufnagel DE, Dietrich A, Birnbaumer L, Malik AB, Mehta D. TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation. The Journal of Experimental Medicine. 209: 1953-68. PMID 23045603 DOI: 10.1085/Jgp1405Oia9  0.489
2012 Davis J, Burr AR, Davis GF, Birnbaumer L, Molkentin JD. A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo. Developmental Cell. 23: 705-15. PMID 23022034 DOI: 10.1016/J.Devcel.2012.08.017  0.336
2012 Yildirim E, Carey MA, Card JW, Dietrich A, Flake GP, Zhang Y, Bradbury JA, Rebolloso Y, Germolec DR, Morgan DL, Zeldin DC, Birnbaumer L. Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice. American Journal of Physiology. Lung Cellular and Molecular Physiology. 303: L539-49. PMID 22797250 DOI: 10.1152/Ajplung.00389.2011  0.711
2012 Quick K, Zhao J, Eijkelkamp N, Linley JE, Rugiero F, Cox JJ, Raouf R, Gringhuis M, Sexton JE, Abramowitz J, Taylor R, Forge A, Ashmore J, Kirkwood N, Kros CJ, ... ... Birnbaumer L, et al. TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells. Open Biology. 2: 120068. PMID 22724068 DOI: 10.1098/rsob.120068  0.312
2012 Senadheera S, Kim Y, Grayson TH, Toemoe S, Kochukov MY, Abramowitz J, Housley GD, Bertrand RL, Chadha PS, Bertrand PP, Murphy TV, Tare M, Birnbaumer L, Marrelli SP, Sandow SL. Transient receptor potential canonical type 3 channels facilitate endothelium-derived hyperpolarization-mediated resistance artery vasodilator activity. Cardiovascular Research. 95: 439-47. PMID 22721989 DOI: 10.1093/cvr/cvs208  0.398
2012 Molnar T, Barabas P, Birnbaumer L, Punzo C, Kefalov V, Križaj D. Store-operated channels regulate intracellular calcium in mammalian rods. The Journal of Physiology. 590: 3465-81. PMID 22674725 DOI: 10.1113/Jphysiol.2012.234641  0.382
2012 Selvaraj S, Sun Y, Watt JA, Wang S, Lei S, Birnbaumer L, Singh BB. Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling. The Journal of Clinical Investigation. 122: 1354-67. PMID 22446186 DOI: 10.1172/Jci61332  0.345
2012 Zanou N, Schakman O, Louis P, Ruegg UT, Dietrich A, Birnbaumer L, Gailly P. Trpc1 ion channel modulates phosphatidylinositol 3-kinase/Akt pathway during myoblast differentiation and muscle regeneration. The Journal of Biological Chemistry. 287: 14524-34. PMID 22399301 DOI: 10.1074/Jbc.M112.341784  0.542
2012 Tang G, Wang Y, Park S, Bajpayee NS, Vi D, Nagaoka Y, Birnbaumer L, Jiang M. Go2 G protein mediates galanin inhibitory effects on insulin release from pancreatic β cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 2636-41. PMID 22308501 DOI: 10.1073/Pnas.1200100109  0.323
2012 Gugger OS, Hartmann J, Birnbaumer L, Kapfhammer JP. P/Q-type and T-type calcium channels, but not type 3 transient receptor potential cation channels, are involved in inhibition of dendritic growth after chronic metabotropic glutamate receptor type 1 and protein kinase C activation in cerebellar Purkinje cells. The European Journal of Neuroscience. 35: 20-33. PMID 22188405 DOI: 10.1111/J.1460-9568.2011.07942.X  0.426
2012 Phelan KD, Mock MM, Kretz O, Shwe UT, Kozhemyakin M, Greenfield LJ, Dietrich A, Birnbaumer L, Freichel M, Flockerzi V, Zheng F. Heteromeric canonical transient receptor potential 1 and 4 channels play a critical role in epileptiform burst firing and seizure-induced neurodegeneration. Molecular Pharmacology. 81: 384-92. PMID 22144671 DOI: 10.1124/Mol.111.075341  0.584
2012 Shi J, Ju M, Abramowitz J, Large WA, Birnbaumer L, Albert AP. TRPC1 proteins confer PKC and phosphoinositol activation on native heteromeric TRPC1/C5 channels in vascular smooth muscle: comparative study of wild-type and TRPC1-/- mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 409-19. PMID 21968068 DOI: 10.1096/fj.11-185611  0.445
2011 Klaiber M, Dankworth B, Kruse M, Hartmann M, Nikolaev VO, Yang RB, Völker K, Gassner B, Oberwinkler H, Feil R, Freichel M, Groschner K, Skryabin BV, Frantz S, Birnbaumer L, et al. A cardiac pathway of cyclic GMP-independent signaling of guanylyl cyclase A, the receptor for atrial natriuretic peptide. Proceedings of the National Academy of Sciences of the United States of America. 108: 18500-5. PMID 22027011 DOI: 10.1073/Pnas.1103300108  0.4
2011 Chamero P, Katsoulidou V, Hendrix P, Bufe B, Roberts R, Matsunami H, Abramowitz J, Birnbaumer L, Zufall F, Leinders-Zufall T. G protein G(alpha)o is essential for vomeronasal function and aggressive behavior in mice. Proceedings of the National Academy of Sciences of the United States of America. 108: 12898-903. PMID 21768373 DOI: 10.1073/Pnas.1107770108  0.328
2011 Ding Y, Winters A, Ding M, Graham S, Akopova I, Muallem S, Wang Y, Hong JH, Gryczynski Z, Yang SH, Birnbaumer L, Ma R. Reactive oxygen species-mediated TRPC6 protein activation in vascular myocytes, a mechanism for vasoconstrictor-regulated vascular tone. The Journal of Biological Chemistry. 286: 31799-809. PMID 21768109 DOI: 10.1074/Jbc.M111.248344  0.365
2011 Tano JY, Smedlund K, Lee R, Abramowitz J, Birnbaumer L, Vazquez G. Impairment of survival signaling and efferocytosis in TRPC3-deficient macrophages. Biochemical and Biophysical Research Communications. 410: 643-7. PMID 21684255 DOI: 10.1016/j.bbrc.2011.06.045  0.339
2011 Marom M, Birnbaumer L, Atlas D. Membrane depolarization combined with Gq-activated G-protein-coupled receptors induce transient receptor potential channel 1 (TRPC1)- dependent potentiation of catecholamine release. Neuroscience. 189: 132-45. PMID 21621591 DOI: 10.1016/j.neuroscience.2011.05.007  0.327
2011 Kim MS, Lee KP, Yang D, Shin DM, Abramowitz J, Kiyonaka S, Birnbaumer L, Mori Y, Muallem S. Genetic and pharmacologic inhibition of the Ca2+ influx channel TRPC3 protects secretory epithelia from Ca2+-dependent toxicity. Gastroenterology. 140: 2107-15, 2115.e1-4. PMID 21354153 DOI: 10.1053/J.Gastro.2011.02.052  0.379
2011 Perez-Leighton CE, Schmidt TM, Abramowitz J, Birnbaumer L, Kofuji P. Intrinsic phototransduction persists in melanopsin-expressing ganglion cells lacking diacylglycerol-sensitive TRPC subunits. The European Journal of Neuroscience. 33: 856-67. PMID 21261756 DOI: 10.1111/J.1460-9568.2010.07583.X  0.365
2011 Fan H, Li P, Zingarelli B, Borg K, Halushka PV, Birnbaumer L, Cook JA. Heterotrimeric Gα(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis. Biochimica Et Biophysica Acta. 1813: 466-72. PMID 21255617 DOI: 10.1016/j.bbamcr.2011.01.012  0.314
2011 Hong JH, Li Q, Kim MS, Shin DM, Feske S, Birnbaumer L, Cheng KT, Ambudkar IS, Muallem S. Polarized but differential localization and recruitment of STIM1, Orai1 and TRPC channels in secretory cells. Traffic (Copenhagen, Denmark). 12: 232-45. PMID 21054717 DOI: 10.1111/J.1600-0854.2010.01138.X  0.42
2011 Villanueva H, Visbal A, Birnbaumer L, Plummer N, Lewis M. P4-04-02: Smoothened Function as a G-Protein Coupled Receptor in Mammary Epithelial Cells. Cancer Research. 71. DOI: 10.1158/0008-5472.Sabcs11-P4-04-02  0.36
2010 Birnbaumer L, Zurita AR. On the roles of Mg in the activation of G proteins. Journal of Receptor and Signal Transduction Research. 30: 372-5. PMID 20731539 DOI: 10.3109/10799893.2010.508165  0.31
2010 Klaiber M, Kruse M, Völker K, Schröter J, Feil R, Freichel M, Gerling A, Feil S, Dietrich A, Londoño JE, Baba HA, Abramowitz J, Birnbaumer L, Penninger JM, Pongs O, et al. Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2. Basic Research in Cardiology. 105: 583-95. PMID 20352235 DOI: 10.1007/S00395-010-0098-Z  0.571
2010 Phan PA, Tadros SF, Kim Y, Birnbaumer L, Housley GD. Developmental regulation of TRPC3 ion channel expression in the mouse cochlea. Histochemistry and Cell Biology. 133: 437-48. PMID 20229053 DOI: 10.1007/s00418-010-0686-x  0.398
2010 Li Y, Birnbaumer L, Teng CT. Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. Molecular Endocrinology (Baltimore, Md.). 24: 969-80. PMID 20211987 DOI: 10.1210/me.2009-0148  0.353
2010 Tadros SF, Kim Y, Phan PA, Birnbaumer L, Housley GD. TRPC3 ion channel subunit immunolocalization in the cochlea. Histochemistry and Cell Biology. 133: 137-47. PMID 19882163 DOI: 10.1007/s00418-009-0653-6  0.382
2010 Zanou N, Shapovalov G, Louis M, Tajeddine N, Gallo C, Van Schoor M, Anguish I, Cao ML, Schakman O, Dietrich A, Lebacq J, Ruegg U, Roulet E, Birnbaumer L, Gailly P. Role of TRPC1 channel in skeletal muscle function. American Journal of Physiology. Cell Physiology. 298: C149-62. PMID 19846750 DOI: 10.1152/Ajpcell.00241.2009  0.572
2009 Seth M, Zhang ZS, Mao L, Graham V, Burch J, Stiber J, Tsiokas L, Winn M, Abramowitz J, Rockman HA, Birnbaumer L, Rosenberg P. TRPC1 channels are critical for hypertrophic signaling in the heart. Circulation Research. 105: 1023-30. PMID 19797170 DOI: 10.1161/Circresaha.109.206581  0.399
2009 Kim MS, Hong JH, Li Q, Shin DM, Abramowitz J, Birnbaumer L, Muallem S. Deletion of TRPC3 in mice reduces store-operated Ca2+ influx and the severity of acute pancreatitis. Gastroenterology. 137: 1509-17. PMID 19622358 DOI: 10.1053/J.Gastro.2009.07.042  0.378
2009 Albarrán-Juárez J, Gilsbach R, Piekorz RP, Pexa K, Beetz N, Schneider J, Nürnberg B, Birnbaumer L, Hein L. Modulation of alpha2-adrenoceptor functions by heterotrimeric Galphai protein isoforms. The Journal of Pharmacology and Experimental Therapeutics. 331: 35-44. PMID 19589951 DOI: 10.1124/Jpet.109.157230  0.371
2009 Tsvilovskyy VV, Zholos AV, Aberle T, Philipp SE, Dietrich A, Zhu MX, Birnbaumer L, Freichel M, Flockerzi V. Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo. Gastroenterology. 137: 1415-24. PMID 19549525 DOI: 10.1053/J.Gastro.2009.06.046  0.703
2009 Cao C, Huang X, Han Y, Wan Y, Birnbaumer L, Feng GS, Marshall J, Jiang M, Chu WM. Galpha(i1) and Galpha(i3) are required for epidermal growth factor-mediated activation of the Akt-mTORC1 pathway. Science Signaling. 2: ra17. PMID 19401591 DOI: 10.1126/Scisignal.2000118  0.312
2009 Birnbaumer L. The TRPC class of ion channels: a critical review of their roles in slow, sustained increases in intracellular Ca(2+) concentrations. Annual Review of Pharmacology and Toxicology. 49: 395-426. PMID 19281310 DOI: 10.1146/annurev.pharmtox.48.113006.094928  0.41
2009 Liao Y, Plummer NW, George MD, Abramowitz J, Zhu MX, Birnbaumer L. A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry. Proceedings of the National Academy of Sciences of the United States of America. 106: 3202-6. PMID 19221033 DOI: 10.1073/Pnas.0813346106  0.613
2009 Abramowitz J, Birnbaumer L. Physiology and pathophysiology of canonical transient receptor potential channels. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 297-328. PMID 18940894 DOI: 10.1096/fj.08-119495  0.418
2008 Hartmann J, Dragicevic E, Adelsberger H, Henning HA, Sumser M, Abramowitz J, Blum R, Dietrich A, Freichel M, Flockerzi V, Birnbaumer L, Konnerth A. TRPC3 channels are required for synaptic transmission and motor coordination. Neuron. 59: 392-8. PMID 18701065 DOI: 10.1016/J.Neuron.2008.06.009  0.549
2008 Chaudhuri P, Colles SM, Bhat M, Van Wagoner DR, Birnbaumer L, Graham LM. Elucidation of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement. Molecular Biology of the Cell. 19: 3203-11. PMID 18495872 DOI: 10.1091/mbc.E07-08-0765  0.441
2008 Young A, Powelson EB, Whitney IE, Raven MA, Nusinowitz S, Jiang M, Birnbaumer L, Reese BE, Farber DB. Involvement of OA1, an intracellular GPCR, and G alpha i3, its binding protein, in melanosomal biogenesis and optic pathway formation. Investigative Ophthalmology & Visual Science. 49: 3245-52. PMID 18378571 DOI: 10.1167/Iovs.08-1806  0.314
2008 Liao Y, Erxleben C, Abramowitz J, Flockerzi V, Zhu MX, Armstrong DL, Birnbaumer L. Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels. Proceedings of the National Academy of Sciences of the United States of America. 105: 2895-900. PMID 18287061 DOI: 10.1073/Pnas.0712288105  0.628
2008 Zurita AR, Birnbaumer L. The same mutation in Gsalpha and transducin alpha reveals behavioral differences between these highly homologous G protein alpha-subunits. Proceedings of the National Academy of Sciences of the United States of America. 105: 2363-8. PMID 18258741 DOI: 10.1073/pnas.0712261105  0.334
2008 Foller M, Kasinathan RS, Koka S, Lang C, Shumilina E, Birnbaumer L, Lang F, Huber SM. TRPC6 contributes to the Ca(2+) leak of human erythrocytes. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 21: 183-92. PMID 18209485 DOI: 10.1159/000113760  0.402
2007 Liu X, Cheng KT, Bandyopadhyay BC, Pani B, Dietrich A, Paria BC, Swaim WD, Beech D, Yildrim E, Singh BB, Birnbaumer L, Ambudkar IS. Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice. Proceedings of the National Academy of Sciences of the United States of America. 104: 17542-7. PMID 17956991 DOI: 10.1073/Pnas.0701254104  0.605
2007 Dietrich A, Kalwa H, Storch U, Mederos y Schnitzler M, Salanova B, Pinkenburg O, Dubrovska G, Essin K, Gollasch M, Birnbaumer L, Gudermann T. Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1. Pflã¼Gers Archiv : European Journal of Physiology. 455: 465-77. PMID 17647013 DOI: 10.1007/S00424-007-0314-3  0.666
2007 Liao Y, Erxleben C, Yildirim E, Abramowitz J, Armstrong DL, Birnbaumer L. Orai proteins interact with TRPC channels and confer responsiveness to store depletion. Proceedings of the National Academy of Sciences of the United States of America. 104: 4682-7. PMID 17360584 DOI: 10.1073/Pnas.0611692104  0.677
2007 Gohla A, Klement K, Piekorz RP, Pexa K, vom Dahl S, Spicher K, Dreval V, Häussinger D, Birnbaumer L, Nürnberg B. An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liver. Proceedings of the National Academy of Sciences of the United States of America. 104: 3003-8. PMID 17296938 DOI: 10.1073/pnas.0611434104  0.337
2007 Thompson BD, Jin Y, Wu KH, Colvin RA, Luster AD, Birnbaumer L, Wu MX. Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling. The Journal of Biological Chemistry. 282: 9547-55. PMID 17289675 DOI: 10.1074/jbc.M610931200  0.339
2007 Birnbaumer L. Expansion of signal transduction by G proteins. The second 15 years or so: from 3 to 16 alpha subunits plus betagamma dimers. Biochimica Et Biophysica Acta. 1768: 772-93. PMID 17258171 DOI: 10.1016/j.bbamem.2006.12.002  0.343
2007 Abramowitz J, Birnbaumer L. Know thy neighbor: a survey of diseases and complex syndromes that map to chromosomal regions encoding TRP channels. Handbook of Experimental Pharmacology. 379-408. PMID 17225326 DOI: 10.1007/978-3-540-34891-7_23  0.32
2007 Yildirim E, Birnbaumer L. TRPC2: molecular biology and functional importance. Handbook of Experimental Pharmacology. 53-75. PMID 17217050 DOI: 10.1007/978-3-540-34891-7_3  0.677
2007 Birnbaumer L. The discovery of signal transduction by G proteins: a personal account and an overview of the initial findings and contributions that led to our present understanding. Biochimica Et Biophysica Acta. 1768: 756-71. PMID 17141178 DOI: 10.1016/j.bbamem.2006.09.027  0.323
2006 Ghil S, Choi JM, Kim SS, Lee YD, Liao Y, Birnbaumer L, Suh-Kim H. Compartmentalization of protein kinase A signaling by the heterotrimeric G protein Go. Proceedings of the National Academy of Sciences of the United States of America. 103: 19158-63. PMID 17148597 DOI: 10.1073/pnas.0609392103  0.304
2006 Erxleben C, Liao Y, Gentile S, Chin D, Gomez-Alegria C, Mori Y, Birnbaumer L, Armstrong DL. Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices. Proceedings of the National Academy of Sciences of the United States of America. 103: 3932-7. PMID 16537462 DOI: 10.1073/pnas.0511322103  0.362
2006 Kawasaki BT, Liao Y, Birnbaumer L. Role of Src in C3 transient receptor potential channel function and evidence for a heterogeneous makeup of receptor- and store-operated Ca2+ entry channels. Proceedings of the National Academy of Sciences of the United States of America. 103: 335-40. PMID 16407161 DOI: 10.1073/Pnas.0508030102  0.787
2005 Dietrich A, Mederos Y Schnitzler M, Gollasch M, Gross V, Storch U, Dubrovska G, Obst M, Yildirim E, Salanova B, Kalwa H, Essin K, Pinkenburg O, Luft FC, Gudermann T, Birnbaumer L. Increased vascular smooth muscle contractility in TRPC6-/- mice. Molecular and Cellular Biology. 25: 6980-9. PMID 16055711 DOI: 10.1128/Mcb.25.16.6980-6989.2005  0.74
2005 Skokowa J, Ali SR, Felda O, Kumar V, Konrad S, Shushakova N, Schmidt RE, Piekorz RP, Nürnberg B, Spicher K, Birnbaumer L, Zwirner J, Claassens JW, Verbeek JS, van Rooijen N, et al. Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation. Journal of Immunology (Baltimore, Md. : 1950). 174: 3041-50. PMID 15728518 DOI: 10.4049/Jimmunol.174.5.3041  0.367
2005 Yildirim E, Kawasaki BT, Birnbaumer L. Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel. Proceedings of the National Academy of Sciences of the United States of America. 102: 3307-11. PMID 15728370 DOI: 10.1073/Pnas.0409908102  0.811
2004 Abramowitz J, Grenet D, Birnbaumer M, Torres HN, Birnbaumer L. XLalphas, the extra-long form of the alpha-subunit of the Gs G protein, is significantly longer than suspected, and so is its companion Alex. Proceedings of the National Academy of Sciences of the United States of America. 101: 8366-71. PMID 15148396 DOI: 10.1073/pnas.0308758101  0.352
2004 D'Angelo MA, Sanguineti S, Reece JM, Birnbaumer L, Torres HN, Flawiá MM. Identification, characterization and subcellular localization of TcPDE1, a novel cAMP-specific phosphodiesterase from Trypanosoma cruzi. The Biochemical Journal. 378: 63-72. PMID 14556647 DOI: 10.1042/BJ20031147  0.34
2003 Foerster K, Groner F, Matthes J, Koch WJ, Birnbaumer L, Herzig S. Cardioprotection specific for the G protein Gi2 in chronic adrenergic signaling through beta 2-adrenoceptors. Proceedings of the National Academy of Sciences of the United States of America. 100: 14475-80. PMID 14612574 DOI: 10.1073/Pnas.1936026100  0.356
2003 Birnbaumer L, Yildirim E, Abramowitz J, Yidirim E. A comparison of the genes coding for canonical TRP channels and their M, V and P relatives. Cell Calcium. 33: 419-32. PMID 12765687 DOI: 10.1016/S0143-4160(03)00068-X  0.621
2003 Trebak M, St J Bird G, McKay RR, Birnbaumer L, Putney JW. Signaling mechanism for receptor-activated canonical transient receptor potential 3 (TRPC3) channels. The Journal of Biological Chemistry. 278: 16244-52. PMID 12606542 DOI: 10.1074/Jbc.M300544200  0.314
2003 Yildirim E, Dietrich A, Birnbaumer L. The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus. Proceedings of the National Academy of Sciences of the United States of America. 100: 2220-5. PMID 12601176 DOI: 10.1073/Pnas.0438036100  0.713
2003 Erxleben C, Gomez-Alegria C, Darden T, Mori Y, Birnbaumer L, Armstrong DL. Modulation of cardiac Ca(V)1.2 channels by dihydropyridine and phosphatase inhibitor requires Ser-1142 in the domain III pore loop. Proceedings of the National Academy of Sciences of the United States of America. 100: 2929-34. PMID 12601159 DOI: 10.1073/Pnas.2628046100  0.419
2002 Birnbaumer L. TRPC4 knockout mice: the coming of age of TRP channels as gates of calcium entry responsible for cellular responses. Circulation Research. 91: 1-3. PMID 12114313 DOI: 10.1161/01.RES.0000026600.67226.92  0.419
2002 Mukherjee S, Gurevich VV, Preninger A, Hamm HE, Bader MF, Fazleabas AT, Birnbaumer L, Hunzicker-Dunn M. Aspartic acid 564 in the third cytoplasmic loop of the luteinizing hormone/choriogonadotropin receptor is crucial for phosphorylation-independent interaction with arrestin2. The Journal of Biological Chemistry. 277: 17916-27. PMID 11867621 DOI: 10.1074/Jbc.M110479200  0.578
2002 Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, et al. A unified nomenclature for the superfamily of TRP cation channels. Molecular Cell. 9: 229-31. PMID 11864597 DOI: 10.1016/S1097-2765(02)00448-3  0.523
2002 Hunzicker-Dunn M, Birnbaumer L. Cell-free membrane desensitization assay for G protein-coupled receptors. Methods in Enzymology. 343: 394-404. PMID 11665580 DOI: 10.1016/S0076-6879(02)43147-3  0.634
2001 Singh BB, Zheng C, Liu X, Lockwich T, Liao D, Zhu MX, Birnbaumer L, Ambudkar IS. Trp1-dependent enhancement of salivary gland fluid secretion: role of store-operated calcium entry. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 1652-4. PMID 11427516 DOI: 10.1096/Fj.00-0749Fje  0.537
2001 Tang J, Lin Y, Zhang Z, Tikunova S, Birnbaumer L, Zhu MX. Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels. The Journal of Biological Chemistry. 276: 21303-10. PMID 11290752 DOI: 10.1074/Jbc.M102316200  0.556
2001 Jiang M, Spicher K, Boulay G, Wang Y, Birnbaumer L. Most central nervous system D2 dopamine receptors are coupled to their effectors by Go. Proceedings of the National Academy of Sciences of the United States of America. 98: 3577-82. PMID 11248120 DOI: 10.1073/Pnas.051632598  0.315
2001 Zhang Z, Tang J, Tikunova S, Johnson JD, Chen Z, Qin N, Dietrich A, Stefani E, Birnbaumer L, Zhu MX. Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain. Proceedings of the National Academy of Sciences of the United States of America. 98: 3168-73. PMID 11248050 DOI: 10.1073/Pnas.051632698  0.657
2000 Birnbaumer L, Boulay G, Brown D, Jiang M, Dietrich A, Mikoshiba K, Zhu X, Qin N. Mechanism of capacitative Ca2+ entry (CCE): interaction between IP3 receptor and TRP links the internal calcium storage compartment to plasma membrane CCE channels. Recent Progress in Hormone Research. 55: 127-61; discussion 1. PMID 11036936  0.582
2000 Platano D, Qin N, Noceti F, Birnbaumer L, Stefani E, Olcese R. Expression of the alpha(2)delta subunit interferes with prepulse facilitation in cardiac L-type calcium channels. Biophysical Journal. 78: 2959-72. PMID 10827975 DOI: 10.1016/S0006-3495(00)76835-4  0.334
2000 Ertel EA, Campbell KP, Harpold MM, Hofmann F, Mori Y, Perez-Reyes E, Schwartz A, Snutch TP, Tanabe T, Birnbaumer L, Tsien RW, Catterall WA. Nomenclature of voltage-gated calcium channels. Neuron. 25: 533-5. PMID 10774722  0.534
2000 Ma HT, Patterson RL, van Rossum DB, Birnbaumer L, Mikoshiba K, Gill DL. Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels. Science (New York, N.Y.). 287: 1647-51. PMID 10698739 DOI: 10.1126/Science.287.5458.1647  0.338
1999 Boulay G, Brown DM, Qin N, Jiang M, Dietrich A, Zhu MX, Chen Z, Birnbaumer M, Mikoshiba K, Birnbaumer L. Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry. Proceedings of the National Academy of Sciences of the United States of America. 96: 14955-60. PMID 10611319 DOI: 10.1073/Pnas.96.26.14955  0.76
1999 Rajagopalan-Gupta RM, Mukherjee S, Zhu X, Ho YK, Hamm H, Birnbaumer M, Birnbaumer L, Hunzicker-Dunn M. Roles of Gi and Gq/11 in mediating desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes. Endocrinology. 140: 1612-21. PMID 10098495 DOI: 10.1210/Endo.140.4.6657  0.596
1999 Qin N, Olcese R, Bransby M, Lin T, Birnbaumer L. Ca2+-induced inhibition of the cardiac Ca2+ channel depends on calmodulin. Proceedings of the National Academy of Sciences of the United States of America. 96: 2435-8. PMID 10051660 DOI: 10.1073/Pnas.96.5.2435  0.367
1999 Vannier B, Peyton M, Boulay G, Brown D, Qin N, Jiang M, Zhu X, Birnbaumer L. Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel. Proceedings of the National Academy of Sciences of the United States of America. 96: 2060-4. PMID 10051594 DOI: 10.1073/Pnas.96.5.2060  0.608
1998 Kiselyov K, Xu X, Mozhayeva G, Kuo T, Pessah I, Mignery G, Zhu X, Birnbaumer L, Muallem S. Functional interaction between InsP3 receptors and store-operated Htrp3 channels. Nature. 396: 478-82. PMID 9853757 DOI: 10.1038/24890  0.337
1998 Ottolia M, Platano D, Qin N, Noceti F, Birnbaumer M, Toro L, Birnbaumer L, Stefani E, Olcese R. Functional coupling between human E-type Ca2+ channels and mu opioid receptors expressed in Xenopus oocytes. Febs Letters. 427: 96-102. PMID 9613607 DOI: 10.1016/S0014-5793(98)00401-3  0.398
1998 Qin N, Platano D, Olcese R, Costantin JL, Stefani E, Birnbaumer L. Unique regulatory properties of the type 2a Ca2+ channel beta subunit caused by palmitoylation. Proceedings of the National Academy of Sciences of the United States of America. 95: 4690-5. PMID 9539800 DOI: 10.1073/Pnas.95.8.4690  0.44
1998 Vannier B, Zhu X, Brown D, Birnbaumer L. The membrane topology of human transient receptor potential 3 as inferred from glycosylation-scanning mutagenesis and epitope immunocytochemistry. The Journal of Biological Chemistry. 273: 8675-9. PMID 9535843 DOI: 10.1074/Jbc.273.15.8675  0.564
1998 Jiang M, Gold MS, Boulay G, Spicher K, Peyton M, Brabet P, Srinivasan Y, Rudolph U, Ellison G, Birnbaumer L. Multiple neurological abnormalities in mice deficient in the G protein Go. Proceedings of the National Academy of Sciences of the United States of America. 95: 3269-74. PMID 9501252 DOI: 10.1073/pnas.95.6.3269  0.303
1998 Zhu X, Jiang M, Birnbaumer L. Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry. The Journal of Biological Chemistry. 273: 133-42. PMID 9417057 DOI: 10.1074/jbc.273.1.133  0.32
1997 Boulay G, Zhu X, Peyton M, Jiang M, Hurst R, Stefani E, Birnbaumer L. Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein. The Journal of Biological Chemistry. 272: 29672-80. PMID 9368034 DOI: 10.1074/Jbc.272.47.29672  0.326
1997 Qin N, Platano D, Olcese R, Stefani E, Birnbaumer L. Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors. Proceedings of the National Academy of Sciences of the United States of America. 94: 8866-71. PMID 9238069 DOI: 10.1073/Pnas.94.16.8866  0.44
1997 Zhou J, Olcese R, Qin N, Noceti F, Birnbaumer L, Stefani E. Feedback inhibition of Ca2+ channels by Ca2+ depends on a short sequence of the C terminus that does not include the Ca2+ -binding function of a motif with similarity to Ca2+ -binding domains. Proceedings of the National Academy of Sciences of the United States of America. 94: 2301-5. PMID 9122189 DOI: 10.1073/Pnas.94.6.2301  0.334
1997 Tareilus E, Roux M, Qin N, Olcese R, Zhou J, Stefani E, Birnbaumer L. A Xenopus oocyte beta subunit: evidence for a role in the assembly/expression of voltage-gated calcium channels that is separate from its role as a regulatory subunit. Proceedings of the National Academy of Sciences of the United States of America. 94: 1703-8. PMID 9050842 DOI: 10.1073/Pnas.94.5.1703  0.37
1996 Suh-Kim H, Wei X, Klos A, Pan S, Ruth P, Flockerzi V, Hofmann F, Perez-Reyes E, Birnbaumer L. Reconstitution of the skeletal muscle dihydropyridine receptor. Functional interaction among alpha 1, beta, gamma and alpha 2 delta subunits. Receptors & Channels. 4: 217-25. PMID 9065970  0.576
1996 Birnbaumer L, Zhu X, Jiang M, Boulay G, Peyton M, Vannier B, Brown D, Platano D, Sadeghi H, Stefani E, Birnbaumer M. On the molecular basis and regulation of cellular capacitative calcium entry: roles for Trp proteins. Proceedings of the National Academy of Sciences of the United States of America. 93: 15195-202. PMID 8986787 DOI: 10.1073/Pnas.93.26.15195  0.575
1996 Zhu X, Jiang M, Peyton M, Boulay G, Hurst R, Stefani E, Birnbaumer L. trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 85: 661-71. PMID 8646775 DOI: 10.1016/S0092-8674(00)81233-7  0.308
1996 Rudolph U, Spicher K, Birnbaumer L. Adenylyl cyclase inhibition and altered G protein subunit expression and ADP-ribosylation patterns in tissues and cells from Gi2 alpha-/-mice. Proceedings of the National Academy of Sciences of the United States of America. 93: 3209-14. PMID 8622915 DOI: 10.1073/Pnas.93.8.3209  0.331
1995 Gudermann T, Birnbaumer M, Birnbaumer L. Homologous desensitization of the murine luteinizing hormone receptor expressed in L cells. Molecular and Cellular Endocrinology. 110: 125-35. PMID 7672443 DOI: 10.1016/0303-7207(95)03538-I  0.538
1995 Rudolph U, Finegold MJ, Rich SS, Harriman GR, Srinivasan Y, Brabet P, Boulay G, Bradley A, Birnbaumer L. Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nature Genetics. 10: 143-50. PMID 7663509 DOI: 10.1038/ng0695-143  0.318
1995 Wei X, Pan S, Lang W, Kim H, Schneider T, Perez-Reyes E, Birnbaumer L. Molecular determinants of cardiac Ca2+ channel pharmacology. Subunit requirement for the high affinity and allosteric regulation of dihydropyridine binding. The Journal of Biological Chemistry. 270: 27106-11. PMID 7592963 DOI: 10.1074/jbc.270.45.27106  0.566
1995 Schneider T, Perez-Reyes E, Nyormoi O, Wei X, Crawford GD, Smith RG, Appel SH, Birnbaumer L. Alpha-1 subunits of voltage gated Ca2+ channels in the mesencephalon x neuroblastoma hybrid cell line MES23.5. Neuroscience. 68: 479-85. PMID 7477958 DOI: 10.1016/0306-4522(95)00147-B  0.575
1994 Olcese R, Qin N, Schneider T, Neely A, Wei X, Stefani E, Birnbaumer L. The amino terminus of a calcium channel beta subunit sets rates of channel inactivation independently of the subunit's effect on activation. Neuron. 13: 1433-8. PMID 7993634 DOI: 10.1016/0896-6273(94)90428-6  0.327
1994 Wei X, Neely A, Lacerda AE, Olcese R, Stefani E, Perez-Reyes E, Birnbaumer L. Modification of Ca2+ channel activity by deletions at the carboxyl terminus of the cardiac alpha 1 subunit. The Journal of Biological Chemistry. 269: 1635-40. PMID 7507480  0.588
1993 Gudermann T, Levy FO, Birnbaumer M, Birnbaumer L, Kaumann AJ. Human S31 serotonin receptor clone encodes a 5-hydroxytryptamine1E-like serotonin receptor. Molecular Pharmacology. 43: 412-8. PMID 8450834  0.492
1993 Zhu X, Gudermann T, Birnbaumer M, Birnbaumer L. A luteinizing hormone receptor with a severely truncated cytoplasmic tail (LHR-ct628) desensitizes to the same degree as the full-length receptor. The Journal of Biological Chemistry. 268: 1723-8. PMID 8420950  0.465
1993 Rosenthal W, Gudermann T, Antaramian A, Seibold A, Lonergan M, Arthus MF, Hendy GN, Birnbaumer L, Bichet DG, Birnbaumer M. Gs-activating receptors: modes of transmembrane signalling and genetic defects. Advances in Second Messenger and Phosphoprotein Research. 28: 47-55. PMID 8398417  0.441
1993 Blitzer RD, Omri G, De Vivo M, Carty DJ, Premont RT, Codina J, Birnbaumer L, Cotecchia S, Caron MG, Lefkowitz RJ. Coupling of the expressed alpha 1B-adrenergic receptor to the phospholipase C pathway in Xenopus oocytes. The role of Go. The Journal of Biological Chemistry. 268: 7532-7. PMID 8385110  0.554
1993 Scornik FS, Codina J, Birnbaumer L, Toro L. Modulation of coronary smooth muscle KCa channels by Gs alpha independent of phosphorylation by protein kinase A. The American Journal of Physiology. 265: H1460-5. PMID 8238435  0.302
1993 Neely A, Wei X, Olcese R, Birnbaumer L, Stefani E. Potentiation by the beta subunit of the ratio of the ionic current to the charge movement in the cardiac calcium channel. Science (New York, N.Y.). 262: 575-8. PMID 8211185 DOI: 10.1126/Science.8211185  0.34
1993 Castellano A, Wei X, Birnbaumer L, Perez-Reyes E. Cloning and expression of a neuronal calcium channel beta subunit. The Journal of Biological Chemistry. 268: 12359-66. PMID 7685340  0.557
1993 Castellano A, Wei X, Birnbaumer L, Perez-Reyes E. Cloning and expression of a third calcium channel beta subunit. The Journal of Biological Chemistry. 268: 3450-5. PMID 7679112  0.557
1992 Levy FO, Gudermann T, Birnbaumer M, Kaumann AJ, Birnbaumer L. Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase. Febs Letters. 296: 201-6. PMID 1733778 DOI: 10.1016/0014-5793(92)80379-U  0.493
1992 Levy FO, Gudermann T, Perez-Reyes E, Birnbaumer M, Kaumann AJ, Birnbaumer L. Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype. The Journal of Biological Chemistry. 267: 7553-62. PMID 1559993  0.66
1992 Graf R, Mattera R, Codina J, Evans T, Ho YK, Estes MK, Birnbaumer L. Studies on the interaction of alpha subunits of GTP-binding proteins with beta gamma dimers. European Journal of Biochemistry / Febs. 210: 609-19. PMID 1459143 DOI: 10.1111/J.1432-1033.1992.TB17461.X  0.307
1992 Perez-Reyes E, Castellano A, Kim HS, Bertrand P, Baggstrom E, Lacerda AE, Wei XY, Birnbaumer L. Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel. The Journal of Biological Chemistry. 267: 1792-7. PMID 1370480  0.586
1992 Yaney GC, Wheeler MB, Wei X, Perez-Reyes E, Birnbaumer L, Boyd AE, Moss LG. Cloning of a novel alpha 1-subunit of the voltage-dependent calcium channel from the beta-cell. Molecular Endocrinology (Baltimore, Md.). 6: 2143-52. PMID 1337146 DOI: 10.1210/mend.6.12.1337146  0.567
1992 Gudermann T, Nichols C, Levy FO, Birnbaumer M, Birnbaumer L. Ca2+ mobilization by the LH receptor expressed in Xenopus oocytes independent of 3',5'-cyclic adenosine monophosphate formation: evidence for parallel activation of two signaling pathways. Molecular Endocrinology (Baltimore, Md.). 6: 272-8. PMID 1314958 DOI: 10.1210/Mend.6.2.1314958  0.534
1992 Gudermann T, Birnbaumer M, Birnbaumer L. Evidence for dual coupling of the murine luteinizing hormone receptor to adenylyl cyclase and phosphoinositide breakdown and Ca2+ mobilization. Studies with the cloned murine luteinizing hormone receptor expressed in L cells. The Journal of Biological Chemistry. 267: 4479-88. PMID 1311310  0.537
1991 Brown AM, Yatani A, Kirsch G, Okabe K, VanDongen AM, Birnbaumer L. Control of K+ channels by G proteins. Journal of Bioenergetics and Biomembranes. 23: 499-507. PMID 1917906 DOI: 10.1007/BF00785808  0.679
1991 Davies AO, Su CJ, Balasubramanyam A, Codina J, Birnbaumer L. Abnormal guanine nucleotide regulatory protein in MVP dysautonomia: evidence from reconstitution of Gs. The Journal of Clinical Endocrinology and Metabolism. 72: 867-75. PMID 1900864 DOI: 10.1210/jcem-72-4-867  0.336
1991 Codina J, Carty DJ, Birnbaumer L, Iyengar R. Purification of G proteins. Methods in Enzymology. 195: 177-88. PMID 1851927 DOI: 10.1016/0076-6879(91)95164-F  0.476
1991 Birnbaumer L, Perez-Reyes E, Bertrand P, Gudermann T, Wei XY, Kim H, Castellano A, Codina J. Molecular diversity and function of G proteins and calcium channels. Biology of Reproduction. 44: 207-24. PMID 1849023 DOI: 10.1095/Biolreprod44.2.207  0.675
1991 Brown AM, Yatani A, Kirsch G, VanDongen AM, Schubert B, Codina J, Birnbaumer L. Regulation of ionic channels by G proteins. Advances in Experimental Medicine and Biology. 308: 119-34. PMID 1724872  0.661
1991 Wei XY, Perez-Reyes E, Lacerda AE, Schuster G, Brown AM, Birnbaumer L. Heterologous regulation of the cardiac Ca2+ channel alpha 1 subunit by skeletal muscle beta and gamma subunits. Implications for the structure of cardiac L-type Ca2+ channels. The Journal of Biological Chemistry. 266: 21943-7. PMID 1718988  0.547
1991 Perez-Reyes E, Wei XY, Gudermann T, Birnbaumer L. The use of PCR to probe calcium channel diversity. Journal of Receptor Research. 11: 553-76. PMID 1715921 DOI: 10.3109/10799899109066427  0.647
1991 Lacerda AE, Kim HS, Ruth P, Perez-Reyes E, Flockerzi V, Hofmann F, Birnbaumer L, Brown AM. Normalization of current kinetics by interaction between the alpha 1 and beta subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel. Nature. 352: 527-30. PMID 1650913 DOI: 10.1038/352527a0  0.582
1990 Cantiello HF, Patenaude CR, Codina J, Birnbaumer L, Ausiello DA. G alpha i-3 regulates epithelial Na+ channels by activation of phospholipase A2 and lipoxygenase pathways. The Journal of Biological Chemistry. 265: 21624-8. PMID 2174882  0.3
1990 Perez-Reyes E, Wei XY, Castellano A, Birnbaumer L. Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes. The Journal of Biological Chemistry. 265: 20430-6. PMID 2173707  0.556
1990 Yatani A, Birnbaumer L, Brown AM. Direct coupling of the somatostatin receptor to potassium channels by a G protein. Metabolism: Clinical and Experimental. 39: 91-5. PMID 2169576  0.372
1990 Kim HS, Wei XY, Ruth P, Perez-Reyes E, Flockerzi V, Hofmann F, Birnbaumer L. Studies on the structural requirements for the activity of the skeletal muscle dihydropyridine receptor/slow Ca2+ channel. Allosteric regulation of dihydropyridine binding in the absence of alpha 2 and beta components of the purified protein complex. The Journal of Biological Chemistry. 265: 11858-63. PMID 2164019  0.59
1990 Iyengar R, Birnbaumer L. Roles of G proteins and G protein subunits in signal transduction. Lymphokine Research. 9: 533-7. PMID 2128642  0.468
1990 Carty DJ, Padrell E, Codina J, Birnbaumer L, Hildebrandt JD, Iyengar R. Distinct guanine nucleotide binding and release properties of the three Gi proteins. The Journal of Biological Chemistry. 265: 6268-73. PMID 2108158  0.423
1990 Birnbaumer L, Yatani A, VanDongen AM, Graf R, Codina J, Okabe K, Mattera R, Brown AM. G protein coupling of receptors to ionic channels and other effector systems. British Journal of Clinical Pharmacology. 30: 13S-22S. PMID 1702677 DOI: 10.1111/J.1365-2125.1990.TB05463.X  0.677
1990 Yatani A, Okabe K, Codina J, Birnbaumer L, Brown AM. Heart rate regulation by G proteins acting on the cardiac pacemaker channel. Science (New York, N.Y.). 249: 1163-6. PMID 1697697 DOI: 10.1126/Science.1697697  0.358
1990 Birnbaumer L, Yatani A, VanDongen AM, Graf R, Codina J, Okabe K, Mattera R, Brown AM. G protein coupling of receptors to ionic channels and other effector systems. Society of General Physiologists Series. 45: 169-83. PMID 1696032  0.665
1990 Brown AM, Yatani A, VanDongen AM, Kirsch GE, Codina J, Birnbaumer L. Networking ionic channels by G proteins. Society of General Physiologists Series. 45: 1-9. PMID 1696031  0.641
1990 Brown AM, Birnbaumer L. Ionic channels and their regulation by G protein subunits. Annual Review of Physiology. 52: 197-213. PMID 1691904 DOI: 10.1146/annurev.ph.52.030190.001213  0.311
1989 Mattera R, Graziano MP, Yatani A, Zhou Z, Graf R, Codina J, Birnbaumer L, Gilman AG, Brown AM. Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels. Science (New York, N.Y.). 243: 804-7. PMID 2536957 DOI: 10.1126/Science.2536957  0.301
1989 Birnbaumer L, Codina J, Yatani A, Mattera R, Graf R, Olate J, Themmen AP, Liao CF, Sanford J, Okabe K. Molecular basis of regulation of ionic channels by G proteins. Recent Progress in Hormone Research. 45: 121-206; discussion . PMID 2479060 DOI: 10.1016/B978-0-12-571145-6.50008-X  0.374
1989 Birnbaumer L, VanDongen AM, Codina J, Yatani A, Mattera R, Graf R, Brown AM. Identification of G protein-gated and G protein-modulated ionic channels. Molecular basis for G protein action. Society of General Physiologists Series. 44: 17-54. PMID 2476853  0.642
1989 Perez-Reyes E, Kim HS, Lacerda AE, Horne W, Wei XY, Rampe D, Campbell KP, Brown AM, Birnbaumer L. Induction of calcium currents by the expression of the alpha 1-subunit of the dihydropyridine receptor from skeletal muscle. Nature. 340: 233-6. PMID 2474131 DOI: 10.1038/340233A0  0.555
1989 Brown AM, Birnbaumer L. Ion channels and G proteins. Hospital Practice (Office Ed.). 24: 189-93, 198, 202-4. PMID 2473087 DOI: 10.1080/21548331.1989.11703753  0.374
1989 Brown AM, Yatani A, Codina J, Birnbaumer L. G protein-gated channels. A third major category of ionic channels. American Journal of Hypertension. 2: 124-7. PMID 2465009 DOI: 10.1093/Ajh/2.2.124  0.368
1988 VanDongen AM, Codina J, Olate J, Mattera R, Joho R, Birnbaumer L, Brown AM. Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go. Science (New York, N.Y.). 242: 1433-7. PMID 3144040 DOI: 10.1126/Science.3144040  0.7
1988 Yatani A, Mattera R, Codina J, Graf R, Okabe K, Padrell E, Iyengar R, Brown AM, Birnbaumer L. The G protein-gated atrial K+ channel is stimulated by three distinct Gi alpha-subunits. Nature. 336: 680-2. PMID 3143915 DOI: 10.1038/336680a0  0.473
1988 Yatani A, Hamm H, Codina J, Mazzoni MR, Birnbaumer L, Brown AM. A monoclonal antibody to the alpha subunit of Gk blocks muscarinic activation of atrial K+ channels. Science (New York, N.Y.). 241: 828-31. PMID 2457252 DOI: 10.1126/Science.2457252  0.361
1988 Yatani A, Codina J, Sekura RD, Birnbaumer L, Brown AM. Reconstitution of somatostatin and muscarinic receptor mediated stimulation of K+ channels by isolated GK protein in clonal rat anterior pituitary cell membranes. Molecular Endocrinology (Baltimore, Md.). 1: 283-9. PMID 2456451 DOI: 10.1210/MEND-1-4-283  0.43
1988 Yatani A, Imoto Y, Codina J, Hamilton SL, Brown AM, Birnbaumer L. The stimulatory G protein of adenylyl cyclase, G(s), also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist Journal of Biological Chemistry. 263: 9887-9895. PMID 2454923  0.352
1988 Brown AM, Birnbaumer L. Direct G protein gating of ion channels. The American Journal of Physiology. 254: H401-10. PMID 2450476 DOI: 10.1152/ajpheart.1988.254.3.H401  0.315
1987 Ribeiro-Neto F, Birnbaumer L, Field JB. Incubation of bovine thyroid slices with thyrotropin is associated with a decrease in the ability of pertussus toxin to adenosine diphosphate-ribosylate guanine nucleotide regulatory component(s) Molecular Endocrinology. 1: 482-490. PMID 3155264 DOI: 10.1210/Mend-1-7-482  0.307
1987 Ribeiro-Neto F, Mattera R, Grenet D, Sekura RD, Birnbaumer L, Field JB. Adenosine diphosphate ribosylation of G proteins by pertussis and cholera toxin in isolated membranes. Different requirements for and effects of guanine nucleotides and Mg2+. Molecular Endocrinology (Baltimore, Md.). 1: 472-81. PMID 3155263 DOI: 10.1210/mend-1-7-472  0.304
1987 Toro MJ, Montoya E, Birnbaumer L. Inhibitory regulation of adenylyl cyclases. Evidence inconsistent with beta gamma-complexes of Gi proteins mediating hormonal effects by interfering with activation of Gs. Molecular Endocrinology (Baltimore, Md.). 1: 669-76. PMID 3155258 DOI: 10.1210/mend-1-10-669  0.392
1987 Yatani A, Codina J, Imoto Y, Reeves JP, Birnbaumer L, Brown AM. A G protein directly regulates mammalian cardiac calcium channels. Science (New York, N.Y.). 238: 1288-92. PMID 2446390 DOI: 10.1126/Science.2446390  0.425
1987 Codina J, Yatani A, Grenet D, Brown AM, Birnbaumer L. The alpha subunit of the GTP binding protein Gk opens atrial potassium channels. Science (New York, N.Y.). 236: 442-5. PMID 2436299 DOI: 10.1126/SCIENCE.2436299  0.386
1986 Kirchick HJ, Abramowitz J, Hunzicker-Dunn M, Birnbaumer L. Seasonal variations in the responses of luteal and follicular luteinizing hormone-stimulated adenylyl cyclases to estradiol implants and implant removal in pseudopregnant rabbits Comparative Biochemistry and Physiology -- Part a: Physiology. 84: 709-713. PMID 2875837 DOI: 10.1016/0300-9629(86)90392-0  0.516
1985 Gierschik P, Codina J, Simons C, Birnbaumer L, Spiegel A. Antisera against a guanine nucleotide binding protein from retina cross-react with the beta subunit of the adenylyl cyclase-associated guanine nucleotide binding proteins, Ns and Ni. Proceedings of the National Academy of Sciences of the United States of America. 82: 727-31. PMID 3919382 DOI: 10.1073/Pnas.82.3.727  0.316
1985 Hildebrandt JD, Codina J, Tash JS, Kirchick HJ, Lipschultz L, Sekura RD, Birnbaumer L. The membrane-bound spermatozoal adenylyl cyclase system does not share coupling characteristics with somatic cell adenylyl cyclases. Endocrinology. 116: 1357-66. PMID 3918851 DOI: 10.1210/Endo-116-4-1357  0.332
1985 Birnbaumer L, Codina J, Mattera R, Cerione RA, Hildebrandt JD, Sunyer T, Rojas FJ, Caron MG, Lefkowitz RJ, Iyengar R. Regulation of hormone receptors and adenylyl cyclases by guanine nucleotide binding N proteins. Recent Progress in Hormone Research. 41: 41-99. PMID 2996090 DOI: 10.1016/B978-0-12-571141-8.50006-8  0.484
1985 Ribeiro-Neto FA, Mattera R, Hildebrandt JD, Codina J, Field JB, Birnbaumer L, Sekura RD. ADP-ribosylation of membrane components by pertussis and cholera toxin. Methods in Enzymology. 109: 566-72. PMID 2859516 DOI: 10.1016/0076-6879(85)09115-7  0.314
1984 Cerione RA, Codina J, Benovic JL, Lefkowitz RJ, Birnbaumer L, Caron MG. The mammalian β2-adrenergic receptor: Reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system Biochemistry. 23: 4519-4525. PMID 6149763 DOI: 10.1021/Bi00315A003  0.343
1983 Kirchick HJ, Iyengar R, Birnbaumer L. Human chorionic gonadotropin-induced heterologous desensitization of adenylyl cyclase from highly luteinized rat ovaries: attenuation of regulatory N component activity. Endocrinology. 113: 1638-46. PMID 6313327 DOI: 10.1210/endo-113-5-1638  0.467
1983 Codina J, Hildebrandt J, Iyengar R, Birnbaumer L, Sekura RD, Manclark CR. Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium. Proceedings of the National Academy of Sciences of the United States of America. 80: 4276-80. PMID 6308612 DOI: 10.1073/Pnas.80.14.4276  0.506
1983 Rojas FJ, Swartz TL, Iyengar R, Garber AJ, Birnbaumer L. Monoiodoglucagon: synthesis, purification by high pressure liquid chromatography, and characteristics as a receptor probe. Endocrinology. 113: 711-9. PMID 6307649 DOI: 10.1210/endo-113-2-711  0.428
1983 Hildebrandt JD, Sekura RD, Codina J, Iyengar R, Manclark CR, Birnbaumer L. Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteins. Nature. 302: 706-9. PMID 6300694 DOI: 10.1038/302706A0  0.476
1982 Iyengar R, Birnbaumer L. Hormone receptor modulates the regulatory component of adenylyl cyclase by reducing its requirement for Mg2+ and enhancing its extent of activation by guanine nucleotides. Proceedings of the National Academy of Sciences of the United States of America. 79: 5179-83. PMID 6291028 DOI: 10.1073/PNAS.79.17.5179  0.518
1982 Abramowitz J, Iyengar R, Birnbaumer L. Guanine nucleotide and magnesium ion regulation of the interaction of gonadotropic and beta-adrenergic receptors with their hormones: a comparative study using a single membrane system. Endocrinology. 110: 336-46. PMID 6276131 DOI: 10.1210/endo-110-2-336  0.449
1981 Iyengar R, Birnbaumer L. Hysteretic activation of adenylyl cyclases. I. Effect of Mg ion on the rate of activation by guanine nucleotides and fluoride. The Journal of Biological Chemistry. 256: 11036-41. PMID 7287749  0.385
1981 Iyengar R, Bhat MK, Riser ME, Birnbaumer L. Receptor-specific desensitization of the S49 lymphoma cell adenylyl cyclase. Unaltered behavior of the regulatory component. The Journal of Biological Chemistry. 256: 4810-5. PMID 6262304  0.426
1981 Hunzicker-Dunn M, Birnbaumer L. Studies on the mechanism of luteinizing hormone-induced desensitization of the rabbit follicular adenylyl cyclase system in vitro. Endocrinology. 109: 345-51. PMID 6166463 DOI: 10.1210/Endo-109-2-345  0.591
1980 Birnbaumer L, Swartz TL, Abramowitz J, Mintz PW, Iyengar R. Transient and steady state kinetics of the interaction of guanyl nucleotides with the adenylyl cyclase system from rat liver plasma membranes. Interpretation in terms of a simple two-state model. The Journal of Biological Chemistry. 255: 3542-51. PMID 7364755  0.429
1980 Bhat MK, Iyengar R, Abramowitz J, Bordelon-Riser ME, Birnbaumer L. Naturally soluble component(s) that confer(s) guanine nucleotide and fluoride sensitivity to adenylate cyclase. Proceedings of the National Academy of Sciences of the United States of America. 77: 3836-40. PMID 6933440 DOI: 10.1073/Pnas.77.7.3836  0.523
1980 Iyengar R, Mintz PW, Swartz TL, Birnbaumer L. Divalent cation-induced desensitization of glucagon-stimulable adenylyl cyclase in rat liver plasma membrane. GTP-dependent stimulation by glucagon. The Journal of Biological Chemistry. 255: 11875-82. PMID 6777386  0.436
1980 Iyengar R, Abramowitz J, Bordelon-Riser M, Blume AJ, Birnbaumer L. Regulation of hormone-receptor coupling to adenylyl cyclase. Effects of GTP and GDP. The Journal of Biological Chemistry. 255: 10312-21. PMID 6253469  0.48
1980 Birnbaumer L, Bearer CF, Iyengar R. A two-state model of an enzyme with an allosteric regulatory site capable of metabolizing the regulatory ligand. Simplified mathematical treatments of transient and steady state kinetics of an activator and its competitive inhibition as applied to adenylyl cyclases. The Journal of Biological Chemistry. 255: 3552-7. PMID 6102566  0.377
1979 Hunzicker-Dunn M, Day SL, Abramowitz J, Birnbaumer L. Ovarian responses of pregnant mare serum gonadotropin- and human chorionic gondotropin-primed rats: desensitizing, luteolytic, and ovulatory effects of a single dose of human chorionic gonadotropin. Endocrinology. 105: 442-51. PMID 456322 DOI: 10.1210/Endo-105-2-442  0.567
1979 Abramowitz J, Iyengar R, Birnbaumer L. Guanyl nucleotide regulation of hormonally-responsive adenylyl cyclases. Molecular and Cellular Endocrinology. 16: 129-46. PMID 230102 DOI: 10.1016/0303-7207(79)90022-4  0.454
1979 Iyengar R, Birnbaumer L. Coupling of the glucagon receptor to adenylyl cyclase by GDP: evidence for two levels of regulation of adenylyl cyclase. Proceedings of the National Academy of Sciences of the United States of America. 76: 3189-93. PMID 226958 DOI: 10.1073/PNAS.76.7.3189  0.56
1979 Day S, Abramowitz J, Hunzicker-Dunn M, Birnbaumer L. Interactions among estrogen, prolactin and luteinizing hormone at the level of adenylyl cyclase in the corpus luteum: findings and physiological correlates Advances in Experimental Medicine and Biology. 112: 663-677. PMID 223403 DOI: 10.1007/978-1-4684-3474-3_73  0.566
1979 Hunzicker-Dunn M, Jungmann R, Derda D, Birnbaumer L. LH-induced desensitization of the adenylyl cyclase system in ovarian follicles. Advances in Experimental Medicine and Biology. 112: 27-44. PMID 223390 DOI: 10.1007/978-1-4684-3474-3_3  0.721
1979 Hunzicker-Dunn M, Derda D, Jungmann RA, Birnbaumer L. Resensitization of the desensitized follicular adenylyl cyclase system to luteinizing hormone. Endocrinology. 104: 1785-93. PMID 221192 DOI: 10.1210/Endo-104-6-1785  0.743
1979 Iyengar R, Swartz TL, Birnbaumer L. Coupling of glucagon receptor to adenylyl cyclase. Requirement of a receptor-related guanyl nucleotide binding site for coupling of receptor to the enzyme. The Journal of Biological Chemistry. 254: 1119-23. PMID 216687  0.457
1977 Ryan RJ, Birnbaumer L, Lee CY, Hunzicker-Dunn M. Gonadotropin interactions with the gonad as assessed by receptor binding and adenylyl cyclase activity International Review of Physiology. 13: 85-152. PMID 191421  0.557
1976 Hunzicker-Dunn M, Birnbaumer L. Adenylyl cyclase activities in ovarian tissues. IV. Gonadotrophin-induced desensitization of the luteal adenylyl cyclase throughout pregnancy and pseudopregnancy in the rabbit and the rat. Endocrinology. 99: 211-22. PMID 939195 DOI: 10.1210/Endo-99-1-211  0.535
1976 Hunzicker-Dunn M, Birnbaumer L. Adenylyl cyclase activities in ovarian tissues. III. Regulation of responsiveness to LH, FSH, and PGE1 in the prepubertal, cycling, pregnant, and pseudopregnant rat. Endocrinology. 99: 198-210. PMID 939194 DOI: 10.1210/Endo-99-1-198  0.54
1976 Hunzicker-Dunn M, Birnbaumer L. Adenylyl cyclase activities in ovarian tissues. II. Regulation of responsiveness to LH, FSH, and PGE1 in the rabbit. Endocrinology. 99: 185-97. PMID 939193 DOI: 10.1210/Endo-99-1-185  0.553
1976 Birnbaumer L, Yang PC, Hunzicker-Dunn M, Bockaert J, Duran JM. Adenylyl cyclase activities in ovarian tissues. I. Homogenization and conditions of assay in Graafian follicles and corpora lutea of rabbits, rats, and pigs: regulation by ATP, and some comparative properties Endocrinology. 99: 163-184. PMID 7447 DOI: 10.1210/Endo-99-1-163  0.562
1972 Birnbaumer L, Pohl SL, Rodbell M, Sundby F. The glucagon-sensitive adenylate cyclase system in plasma membranes of rat liver. VII. Hormonal stimulation: reversibility and dependence on concentration of free hormone. The Journal of Biological Chemistry. 247: 2038-43. PMID 5016642  0.54
1972 Pohl SL, Krans HM, Birnbaumer L, Rodbell M. Inactivation of glucagon by plasma membranes of rat liver. The Journal of Biological Chemistry. 247: 2295-301. PMID 4337268  0.513
1971 Rodbell M, Birnbaumer L, Pohl SL, Sundby F. The reaction of glucagon with its receptor: evidence for discrete regions of activity and binding in the glucagon molecule. Proceedings of the National Academy of Sciences of the United States of America. 68: 909-13. PMID 5280527 DOI: 10.1073/Pnas.68.5.909  0.608
1971 Rodbell M, Birnbaumer L, Pohl SL. Characteristics of glucagon action on the hepatic adenylate cyclase system. The Biochemical Journal. 125: 58P-59P. PMID 5145874 DOI: 10.1042/Bj1250058P  0.543
1971 Rodbell M, Krans HM, Pohl SL, Birnbaumer L. The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. IV. Effects of guanylnucleotides on binding of 125I-glucagon. The Journal of Biological Chemistry. 246: 1872-6. PMID 4993962  0.53
1971 Pohl SL, Birnbaumer L, Rodbell M. The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. I. Properties. The Journal of Biological Chemistry. 246: 1849-56. PMID 4993961  0.52
1971 Rodbell M, Birnbaumer L, Pohl SL, Krans HM. The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. V. An obligatory role of guanylnucleotides in glucagon action. The Journal of Biological Chemistry. 246: 1877-82. PMID 4926550  0.528
1971 Pohl SL, Krans HM, Kozyreff V, Birnbaumer L, Rodbell M. The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. VI. Evidence for a role of membrane lipids. The Journal of Biological Chemistry. 246: 4447-54. PMID 4328442  0.522
1971 Rodbell M, Krans HM, Pohl SL, Birnbaumer L. The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. 3. Binding of glucagon: method of assay and specificity. The Journal of Biological Chemistry. 246: 1861-71. PMID 4323237  0.527
1971 Birnbaumer L, Pohl SL, Rodbell M. The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. II. Comparison between glucagon- and fluoride-stimulated activities. The Journal of Biological Chemistry. 246: 1857-60. PMID 4323236  0.539
1970 Rodbell M, Birnbaumer L, Pohl SL, Krans HM. [Properties of the adenyl cyclase systems in liver and adipose cells: the mode of action of hormones]. Acta Diabetologica Latina. 7: 9-63. PMID 5474742  0.508
1970 Birnbaumer L, Pohl SL, Michiel H, Krans MJ, Rodbell M. The actions of hormones on the adenyl cyclase system. Advances in Biochemical Psychopharmacology. 3: 185-208. PMID 4399634  0.512
1970 Rodbell M, Birnbaumer L, Pohl SL. Adenyl cyclase in fat cells. 3. Stimulation by secretin and the effects of trypsin on the receptors for lipolytic hormones. The Journal of Biological Chemistry. 245: 718-22. PMID 4313606  0.558
1969 Birnbaumer L, Rodbell M. Adenyl cyclase in fat cells. II. Hormone receptors. The Journal of Biological Chemistry. 244: 3477-82. PMID 4307453  0.545
1969 Birnbaumer L, Pohl SL, Rodbell M. Adenyl cyclase in fat cells. 1. Properties and the effects of adrenocorticotropin and fluoride. The Journal of Biological Chemistry. 244: 3468-76. PMID 4307452  0.508
1969 Pohl SL, Birnbaumer L, Rodbell M. Glucagon-sensitive adenyl cylase in plasma membrane of hepatic parenchymal cells. Science (New York, N.Y.). 164: 566-7. PMID 4305077 DOI: 10.1126/Science.164.3879.566  0.589
1968 Rodbell M, Jones AB, Chiappe de Cingolani GE, Birnbaumer L. The actions of insulin and catabolic hormones on the plasma membrane of the fat cells. Recent Progress in Hormone Research. 24: 215-54. PMID 4302429 DOI: 10.1016/B978-1-4831-9827-9.50011-3  0.564
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