| Year |
Citation |
Score |
| 2022 |
Vali-Pour M, Lehner B, Supek F. The impact of rare germline variants on human somatic mutation processes. Nature Communications. 13: 3724. PMID 35764656 DOI: 10.1038/s41467-022-31483-1 |
0.311 |
|
| 2021 |
Park S, Supek F, Lehner B. Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers. Nature Communications. 12: 7051. PMID 34862370 DOI: 10.1038/s41467-021-27242-3 |
0.35 |
|
| 2019 |
Lindeboom RGH, Vermeulen M, Lehner B, Supek F. The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy. Nature Genetics. PMID 31659324 DOI: 10.1038/S41588-019-0517-5 |
0.42 |
|
| 2019 |
Perez MF, Lehner B. Vitellogenins - Yolk Gene Function and Regulation in . Frontiers in Physiology. 10: 1067. PMID 31551797 DOI: 10.3389/Fphys.2019.01067 |
0.394 |
|
| 2019 |
Li X, Lalić J, Baeza-Centurion P, Dhar R, Lehner B. Author Correction: Changes in gene expression predictably shift and switch genetic interactions. Nature Communications. 10: 4319. PMID 31530808 DOI: 10.1038/S41467-019-12350-Y |
0.4 |
|
| 2019 |
Bolognesi B, Faure AJ, Seuma M, Schmiedel JM, Tartaglia GG, Lehner B. The mutational landscape of a prion-like domain. Nature Communications. 10: 4162. PMID 31519910 DOI: 10.1038/S41467-019-12101-Z |
0.305 |
|
| 2019 |
Li X, Lalic J, Baeza-Centurion P, Dhar R, Lehner B. Changes in gene expression predictably shift and switch genetic interactions. Nature Communications. 10: 3886. PMID 31467279 DOI: 10.1038/S41467-019-11735-3 |
0.469 |
|
| 2019 |
New AM, Lehner B. Harmonious genetic combinations rewire regulatory networks and flip gene essentiality. Nature Communications. 10: 3657. PMID 31413260 DOI: 10.1038/S41467-019-11523-Z |
0.459 |
|
| 2019 |
Schmiedel JM, Carey LB, Lehner B. Empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise. Nature Communications. 10: 3180. PMID 31320634 DOI: 10.1038/S41467-019-11116-W |
0.337 |
|
| 2019 |
Supek F, Lehner B. Scales and mechanisms of somatic mutation rate variation across the human genome. Dna Repair. 102647. PMID 31307927 DOI: 10.1016/J.Dnarep.2019.102647 |
0.361 |
|
| 2019 |
Domingo J, Baeza-Centurion P, Lehner B. The Causes and Consequences of Genetic Interactions (Epistasis). Annual Review of Genomics and Human Genetics. PMID 31082279 DOI: 10.1146/Annurev-Genom-083118-014857 |
0.385 |
|
| 2019 |
Baeza-Centurion P, Miñana B, Schmiedel JM, Valcárcel J, Lehner B. Combinatorial Genetics Reveals a Scaling Law for the Effects of Mutations on Splicing. Cell. 176: 549-563.e23. PMID 30661752 DOI: 10.1016/J.Cell.2018.12.010 |
0.369 |
|
| 2019 |
Dhar R, Missarova AM, Lehner B, Carey LB. Single cell functional genomics reveals the importance of mitochondria in cell-to-cell phenotypic variation. Elife. 8. PMID 30638445 DOI: 10.7554/Elife.38904 |
0.315 |
|
| 2019 |
Han H, Lehner B, Lee I. Cancer Gene Discovery by Network Analysis of Somatic Mutations Using the MUFFINN Server. Methods in Molecular Biology (Clifton, N.J.). 1907: 37-50. PMID 30542989 DOI: 10.1007/978-1-4939-8967-6_3 |
0.411 |
|
| 2018 |
Avgustinova A, Symeonidi A, Castellanos A, Urdiroz-Urricelqui U, Solé-Boldo L, Martín M, Pérez-Rodríguez I, Prats N, Lehner B, Supek F, Benitah SA. Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in skin tumours. Nature Cell Biology. PMID 30455462 DOI: 10.1038/S41556-018-0233-X |
0.341 |
|
| 2018 |
Park S, Supek F, Lehner B. Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits. Nature Communications. 9: 2601. PMID 29973584 DOI: 10.1038/S41467-018-04900-7 |
0.35 |
|
| 2018 |
Domingo J, Diss G, Lehner B. Pairwise and higher-order genetic interactions during the evolution of a tRNA. Nature. PMID 29849145 DOI: 10.1038/S41586-018-0170-7 |
0.379 |
|
| 2018 |
Diss G, Lehner B. The genetic landscape of a physical interaction. Elife. 7. PMID 29638215 DOI: 10.7554/Elife.32472 |
0.436 |
|
| 2018 |
Diss G, Lehner B. Author response: The genetic landscape of a physical interaction Elife. DOI: 10.7554/Elife.32472.034 |
0.3 |
|
| 2017 |
Perez MF, Francesconi M, Hidalgo-Carcedo C, Lehner B. Maternal age generates phenotypic variation in Caenorhabditis elegans. Nature. 552: 106-109. PMID 29186117 DOI: 10.1038/Nature25012 |
0.319 |
|
| 2017 |
Faure AJ, Schmiedel JM, Lehner B. Systematic Analysis of the Determinants of Gene Expression Noise in Embryonic Stem Cells. Cell Systems. PMID 29102610 DOI: 10.1016/J.Cels.2017.10.003 |
0.391 |
|
| 2017 |
Klosin A, Reis K, Hidalgo-Carcedo C, Casas E, Vavouri T, Lehner B. Impaired DNA replication derepresses chromatin and generates a transgenerationally inherited epigenetic memory. Science Advances. 3: e1701143. PMID 28835928 DOI: 10.1126/Sciadv.1701143 |
0.688 |
|
| 2017 |
Supek F, Lehner B. Clustered Mutation Signatures Reveal that Error-Prone DNA Repair Targets Mutations to Active Genes. Cell. 170: 534-547.e23. PMID 28753428 DOI: 10.1016/J.Cell.2017.07.003 |
0.326 |
|
| 2017 |
Klosin A, Casas E, Hidalgo-Carcedo C, Vavouri T, Lehner B. Transgenerational transmission of environmental information in C. elegans. Science (New York, N.Y.). 356: 320-323. PMID 28428426 DOI: 10.1126/Science.Aah6412 |
0.716 |
|
| 2017 |
Stevens TJ, Lando D, Basu S, Atkinson LP, Cao Y, Lee SF, Leeb M, Wohlfahrt KJ, Boucher W, O'Shaughnessy-Kirwan A, Cramard J, Faure AJ, Ralser M, Blanco E, Morey L, ... ... Lehner B, et al. 3D structures of individual mammalian genomes studied by single-cell Hi-C. Nature. PMID 28289288 DOI: 10.1038/Nature21429 |
0.324 |
|
| 2016 |
Lindeboom RG, Supek F, Lehner B. The rules and impact of nonsense-mediated mRNA decay in human cancers. Nature Genetics. PMID 27618451 DOI: 10.1038/Ng.3664 |
0.342 |
|
| 2016 |
Cho A, Shim JE, Kim E, Supek F, Lehner B, Lee I. MUFFINN: cancer gene discovery via network analysis of somatic mutation data. Genome Biology. 17: 129. PMID 27333808 DOI: 10.1186/S13059-016-0989-X |
0.382 |
|
| 2016 |
Julien P, Miñana B, Baeza-Centurion P, Valcárcel J, Lehner B. The complete local genotype-phenotype landscape for the alternative splicing of a human exon. Nature Communications. 7: 11558. PMID 27161764 DOI: 10.1038/Ncomms11558 |
0.352 |
|
| 2016 |
Klosin A, Lehner B. Mechanisms, timescales and principles of trans-generational epigenetic inheritance in animals. Current Opinion in Genetics & Development. 36: 41-49. PMID 27140512 DOI: 10.1016/J.Gde.2016.04.001 |
0.321 |
|
| 2015 |
Francesconi M, Lehner B. Reconstructing and analysing cellular states, space and time from gene expression profiles of many cells and single cells. Molecular Biosystems. 11: 2690-8. PMID 26273952 DOI: 10.1039/C5Mb00339C |
0.403 |
|
| 2015 |
Park S, Lehner B. Cancer type-dependent genetic interactions between cancer driver alterations indicate plasticity of epistasis across cell types. Molecular Systems Biology. 11: 824. PMID 26227665 DOI: 10.15252/Msb.20156102 |
0.321 |
|
| 2015 |
New AM, Lehner B. Systems biology: Network evolution hinges on history. Nature. 523: 297-8. PMID 26153857 DOI: 10.1038/Nature14537 |
0.423 |
|
| 2015 |
Toufighi K, Yang JS, Luis NM, Aznar Benitah S, Lehner B, Serrano L, Kiel C. Dissecting the calcium-induced differentiation of human primary keratinocytes stem cells by integrative and structural network analyses. Plos Computational Biology. 11: e1004256. PMID 25946651 DOI: 10.1371/Journal.Pcbi.1004256 |
0.363 |
|
| 2015 |
Supek F, Lehner B. Differential DNA mismatch repair underlies mutation rate variation across the human genome. Nature. 521: 81-4. PMID 25707793 DOI: 10.1038/Nature14173 |
0.357 |
|
| 2015 |
Krüger AV, Jelier R, Dzyubachyk O, Zimmerman T, Meijering E, Lehner B. Comprehensive single cell-resolution analysis of the role of chromatin regulators in early C. elegans embryogenesis. Developmental Biology. 398: 153-62. PMID 25446273 DOI: 10.1016/j.ydbio.2014.10.014 |
0.318 |
|
| 2014 |
Barberán-Soler S, Fontrodona L, Ribó A, Lamm AT, Iannone C, Cerón J, Lehner B, Valcárcel J. Co-option of the piRNA pathway for germline-specific alternative splicing of C. elegans TOR. Cell Reports. 8: 1609-16. PMID 25220461 DOI: 10.1016/J.Celrep.2014.08.016 |
0.388 |
|
| 2014 |
Supek F, Lehner B, Hajkova P, Warnecke T. Hydroxymethylated cytosines are associated with elevated C to G transversion rates. Plos Genetics. 10: e1004585. PMID 25211471 DOI: 10.1371/Journal.Pgen.1004585 |
0.334 |
|
| 2014 |
Supek F, Miñana B, Valcárcel J, Gabaldón T, Lehner B. Synonymous mutations frequently act as driver mutations in human cancers. Cell. 156: 1324-35. PMID 24630730 DOI: 10.1016/J.Cell.2014.01.051 |
0.337 |
|
| 2014 |
Krisko A, Copic T, Gabaldón T, Lehner B, Supek F. Inferring gene function from evolutionary change in signatures of translation efficiency. Genome Biology. 15: R44. PMID 24580753 DOI: 10.1186/Gb-2014-15-3-R44 |
0.43 |
|
| 2014 |
Francesconi M, Lehner B. The effects of genetic variation on gene expression dynamics during development. Nature. 505: 208-11. PMID 24270809 DOI: 10.1038/Nature12772 |
0.422 |
|
| 2013 |
Warnecke T, Becker EA, Facciotti MT, Nislow C, Lehner B. Conserved substitution patterns around nucleosome footprints in eukaryotes and Archaea derive from frequent nucleosome repositioning through evolution. Plos Computational Biology. 9: e1003373. PMID 24278010 DOI: 10.1371/Journal.Pcbi.1003373 |
0.371 |
|
| 2013 |
Burga A, Lehner B. Predicting phenotypic variation from genotypes, phenotypes and a combination of the two. Current Opinion in Biotechnology. 24: 803-9. PMID 23540420 DOI: 10.1016/J.Copbio.2013.03.004 |
0.359 |
|
| 2013 |
Park S, Lehner B. Epigenetic epistatic interactions constrain the evolution of gene expression. Molecular Systems Biology. 9: 645. PMID 23423319 DOI: 10.1038/Msb.2013.2 |
0.487 |
|
| 2013 |
Lehner B. Genotype to phenotype: lessons from model organisms for human genetics. Nature Reviews. Genetics. 14: 168-78. PMID 23358379 DOI: 10.1038/Nrg3404 |
0.375 |
|
| 2013 |
Fraser A, Lehner B. Systems Biology of Caenorhabditis elegans Handbook of Systems Biology. 367-390. DOI: 10.1016/B978-0-12-385944-0.00019-8 |
0.41 |
|
| 2012 |
Warnecke T, Supek F, Lehner B. Nucleoid-associated proteins affect mutation dynamics in E. coli in a growth phase-specific manner. Plos Computational Biology. 8: e1002846. PMID 23284284 DOI: 10.1371/Journal.Pcbi.1002846 |
0.301 |
|
| 2012 |
Vavouri T, Lehner B. Human genes with CpG island promoters have a distinct transcription-associated chromatin organization. Genome Biology. 13: R110. PMID 23186133 DOI: 10.1186/Gb-2012-13-11-R110 |
0.717 |
|
| 2012 |
Burga A, Lehner B. Beyond genotype to phenotype: why the phenotype of an individual cannot always be predicted from their genome sequence and the environment that they experience. The Febs Journal. 279: 3765-75. PMID 22934970 DOI: 10.1111/J.1742-4658.2012.08810.X |
0.345 |
|
| 2012 |
Lehner B, Park S. Cancer: Exploiting collateral damage. Nature. 488: 284-5. PMID 22895327 DOI: 10.1038/488284A |
0.406 |
|
| 2012 |
Schuster-Böckler B, Lehner B. Chromatin organization is a major influence on regional mutation rates in human cancer cells. Nature. 488: 504-7. PMID 22820252 DOI: 10.1038/Nature11273 |
0.355 |
|
| 2011 |
Burga A, Casanueva MO, Lehner B. Predicting mutation outcome from early stochastic variation in genetic interaction partners. Nature. 480: 250-3. PMID 22158248 DOI: 10.1038/Nature10665 |
0.385 |
|
| 2011 |
Jelier R, Semple JI, Garcia-Verdugo R, Lehner B. Predicting phenotypic variation in yeast from individual genome sequences. Nature Genetics. 43: 1270-4. PMID 22081227 DOI: 10.1038/Ng.1007 |
0.41 |
|
| 2011 |
Lehner B. Molecular mechanisms of epistasis within and between genes. Trends in Genetics : Tig. 27: 323-31. PMID 21684621 DOI: 10.1016/J.Tig.2011.05.007 |
0.383 |
|
| 2011 |
Francesconi M, Jelier R, Lehner B. Integrated genome-scale prediction of detrimental mutations in transcription networks. Plos Genetics. 7: e1002077. PMID 21637788 DOI: 10.1371/Journal.Pgen.1002077 |
0.494 |
|
| 2011 |
Vavouri T, Lehner B. Chromatin organization in sperm may be the major functional consequence of base composition variation in the human genome. Plos Genetics. 7: e1002036. PMID 21490963 DOI: 10.1371/Journal.Pgen.1002036 |
0.722 |
|
| 2011 |
Lehner B, Kaneko K. Fluctuation and response in biology. Cellular and Molecular Life Sciences : Cmls. 68: 1005-10. PMID 21116679 DOI: 10.1007/S00018-010-0589-Y |
0.301 |
|
| 2010 |
Lehner B. Conflict between noise and plasticity in yeast. Plos Genetics. 6: e1001185. PMID 21079670 DOI: 10.1371/Journal.Pgen.1001185 |
0.333 |
|
| 2010 |
Lee I, Lehner B, Vavouri T, Shin J, Fraser AG, Marcotte EM. Predicting genetic modifier loci using functional gene networks. Genome Research. 20: 1143-53. PMID 20538624 DOI: 10.1101/Gr.102749.109 |
0.771 |
|
| 2010 |
Lehner B. Genes confer similar robustness to environmental, stochastic, and genetic perturbations in yeast. Plos One. 5: e9035. PMID 20140261 DOI: 10.1371/Journal.Pone.0009035 |
0.477 |
|
| 2010 |
Lehner B. Correction: Genes Confer Similar Robustness to Environmental, Stochastic, and Genetic Perturbations in Yeast Plos One. 5. DOI: 10.1371/Annotation/1F52Efd2-4D54-428C-9E03-42F1B2B03Af0 |
0.408 |
|
| 2009 |
Vavouri T, Semple JI, Garcia-Verdugo R, Lehner B. Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity. Cell. 138: 198-208. PMID 19596244 DOI: 10.1016/J.Cell.2009.04.029 |
0.73 |
|
| 2009 |
Vavouri T, Lehner B. Conserved noncoding elements and the evolution of animal body plans. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 31: 727-35. PMID 19492354 DOI: 10.1002/Bies.200900014 |
0.713 |
|
| 2009 |
Bossi A, Lehner B. Tissue specificity and the human protein interaction network. Molecular Systems Biology. 5: 260. PMID 19357639 DOI: 10.1038/Msb.2009.17 |
0.327 |
|
| 2008 |
Vavouri T, Semple JI, Lehner B. Widespread conservation of genetic redundancy during a billion years of eukaryotic evolution. Trends in Genetics : Tig. 24: 485-8. PMID 18786741 DOI: 10.1016/J.Tig.2008.08.005 |
0.738 |
|
| 2008 |
Lehner B, Lee I. Network-guided genetic screening: building, testing and using gene networks to predict gene function. Briefings in Functional Genomics & Proteomics. 7: 217-27. PMID 18445637 DOI: 10.1093/Bfgp/Eln020 |
0.437 |
|
| 2008 |
Tischler J, Lehner B, Fraser AG. Evolutionary plasticity of genetic interaction networks. Nature Genetics. 40: 390-1. PMID 18362882 DOI: 10.1038/Ng.114 |
0.601 |
|
| 2008 |
Lehner B. Selection to minimise noise in living systems and its implications for the evolution of gene expression. Molecular Systems Biology. 4: 170. PMID 18319722 DOI: 10.1038/Msb.2008.11 |
0.375 |
|
| 2008 |
Lee I, Lehner B, Crombie C, Wong W, Fraser AG, Marcotte EM. A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans. Nature Genetics. 40: 181-8. PMID 18223650 DOI: 10.1038/Ng.2007.70 |
0.612 |
|
| 2008 |
Semple JI, Vavouri T, Lehner B. A simple principle concerning the robustness of protein complex activity to changes in gene expression. Bmc Systems Biology. 2: 1. PMID 18171472 DOI: 10.1186/1752-0509-2-1 |
0.712 |
|
| 2007 |
Lehner B. Modelling genotype-phenotype relationships and human disease with genetic interaction networks. The Journal of Experimental Biology. 210: 1559-66. PMID 17449820 DOI: 10.1242/Jeb.002311 |
0.454 |
|
| 2007 |
Vavouri T, Walter K, Gilks WR, Lehner B, Elgar G. Parallel evolution of conserved non-coding elements that target a common set of developmental regulatory genes from worms to humans. Genome Biology. 8: R15. PMID 17274809 DOI: 10.1186/Gb-2007-8-2-R15 |
0.772 |
|
| 2006 |
Lehner B, Tischler J, Fraser AG. RNAi screens in Caenorhabditis elegans in a 96-well liquid format and their application to the systematic identification of genetic interactions. Nature Protocols. 1: 1617-20. PMID 17406454 DOI: 10.1038/Nprot.2006.245 |
0.599 |
|
| 2006 |
Tischler J, Lehner B, Chen N, Fraser AG. Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution. Genome Biology. 7: R69. PMID 16884526 DOI: 10.1186/Gb-2006-7-8-R69 |
0.649 |
|
| 2006 |
Lehner B, Crombie C, Tischler J, Fortunato A, Fraser AG. Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. Nature Genetics. 38: 896-903. PMID 16845399 DOI: 10.1038/Ng1844 |
0.651 |
|
| 2006 |
Lehner B, Calixto A, Crombie C, Tischler J, Fortunato A, Chalfie M, Fraser AG. Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference. Genome Biology. 7: R4. PMID 16507136 DOI: 10.1186/Gb-2006-7-1-R4 |
0.63 |
|
| 2005 |
Lehner B, Tischler J, Fraser AG. Systems biology: where it's at in 2005. Genome Biology. 6: 338. PMID 16086862 DOI: 10.1186/Gb-2005-6-8-338 |
0.468 |
|
| 2004 |
Lehner B, Fraser AG. 5,000 RNAi experiments on a chip. Nature Methods. 1: 103-4. PMID 15782169 DOI: 10.1038/Nmeth1104-103 |
0.573 |
|
| 2004 |
Lehner B, Fraser AG. Protein domains enriched in mammalian tissue-specific or widely expressed genes. Trends in Genetics : Tig. 20: 468-72. PMID 15363898 DOI: 10.1016/J.Tig.2004.08.002 |
0.568 |
|
| 2004 |
Lehner B, Fraser AG. A first-draft human protein-interaction map. Genome Biology. 5: R63. PMID 15345047 DOI: 10.1186/Gb-2004-5-9-R63 |
0.571 |
|
| 2004 |
Lehner B, Sanderson CM. A protein interaction framework for human mRNA degradation. Genome Research. 14: 1315-23. PMID 15231747 DOI: 10.1101/Gr.2122004 |
0.352 |
|
| 2004 |
Lehner B, Fraser AG, Sanderson CM. Technique review: how to use RNA interference. Briefings in Functional Genomics & Proteomics. 3: 68-83. PMID 15163361 DOI: 10.1093/Bfgp/3.1.68 |
0.549 |
|
| 2004 |
Lavorgna G, Dahary D, Lehner B, Sorek R, Sanderson CM, Casari G. In search of antisense. Trends in Biochemical Sciences. 29: 88-94. PMID 15102435 DOI: 10.1016/J.Tibs.2003.12.002 |
0.43 |
|
| 2004 |
Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM. Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. Genomics. 83: 153-67. PMID 14667819 DOI: 10.1016/S0888-7543(03)00235-0 |
0.407 |
|
| 2002 |
Lehner B, Williams G, Campbell RD, Sanderson CM. Antisense transcripts in the human genome. Trends in Genetics : Tig. 18: 63-5. PMID 11818131 DOI: 10.1016/S0168-9525(02)02598-2 |
0.407 |
|
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