Ryan Bruce Corcoran

Affiliations: 
2006 Stanford University, Palo Alto, CA 
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"Ryan Corcoran"

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Matthew P. Scott grad student 2006 Stanford
 (The role of sterols and insulin-like growth factor 2 in medulloblastoma tumorigenesis.)
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Publications

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Russo M, Siravegna G, Blaszkowsky LS, et al. (2015) Tumor heterogeneity and lesion-specific response to targeted therapy in colorectal cancer. Cancer Discovery
Kwak EL, Ahronian LG, Siravegna G, et al. (2015) Molecular heterogeneity and receptor co-amplification drive resistance to targeted therapy in MET-amplified esophagogastric cancer. Cancer Discovery
Corcoran RB, Atreya CE, Falchook GS, et al. (2015) Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Ahronian LG, Sennott EM, Van Allen EM, et al. (2015) Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations. Cancer Discovery. 5: 358-67
Alagesan B, Contino G, Guimaraes AR, et al. (2015) Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 396-404
Zhu Z, Aref AR, Cohoon TJ, et al. (2014) Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit. Cancer Discovery. 4: 452-65
Faber AC, Coffee EM, Costa C, et al. (2014) mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. Cancer Discovery. 4: 42-52
Corcoran RB, Rothenberg SM, Hata AN, et al. (2013) TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanoma. Science Translational Medicine. 5: 196ra98
Corcoran RB, Cheng KA, Hata AN, et al. (2013) Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models. Cancer Cell. 23: 121-8
Corcoran RB, Ebi H, Turke AB, et al. (2012) EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib. Cancer Discovery. 2: 227-35
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