Paul J. Scherz, Ph.D.

Harvard University, Cambridge, MA, United States 
genetics, morphogenesis, limb, evolution
"Paul Scherz"


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Clifford J. Tabin grad student 2005 Harvard
 (The role of descendants of Sonic hedgehog-expressing cells in limb development.)
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Alvers AL, Ryan S, Scherz PJ, et al. (2014) Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling. Development (Cambridge, England). 141: 1110-9
Aanstad P, Santos N, Corbit KC, et al. (2009) The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling. Current Biology : Cb. 19: 1034-9
Morton SU, Scherz PJ, Cordes KR, et al. (2008) microRNA-138 modulates cardiac patterning during embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 105: 17830-5
Tran PV, Haycraft CJ, Besschetnova TY, et al. (2008) THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia. Nature Genetics. 40: 403-10
Scherz PJ, Huisken J, Sahai-Hernandez P, et al. (2008) High-speed imaging of developing heart valves reveals interplay of morphogenesis and function. Development (Cambridge, England). 135: 1179-87
Pearse RV, Scherz PJ, Campbell JK, et al. (2007) A cellular lineage analysis of the chick limb bud. Developmental Biology. 310: 388-400
Scherz PJ, McGlinn E, Nissim S, et al. (2007) Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb. Developmental Biology. 308: 343-54
Harfe BD, Scherz PJ, Nissim S, et al. (2004) Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell. 118: 517-28
Scherz PJ, Harfe BD, McMahon AP, et al. (2004) The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. Science (New York, N.Y.). 305: 396-9
Mitchell KJ, Pinson KI, Kelly OG, et al. (2001) Functional analysis of secreted and transmembrane proteins critical to mouse development. Nature Genetics. 28: 241-9
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