Beatrice Mintz, PhD

Cancer Biology Fox Chase Cancer Center 
Melanoma Development, Progression, and Metastasis in Transgenic Mouse Models
"Beatrice Mintz"
Navis, Adam R., Beatrice Mintz (1921- ). Embryo Project Encyclopedia (2009-01-21). ISSN: 1940-5030
Mintz is a pioneer of genetic engineering techniques, and was among the first scientists to generate both chimeric and transgenic mammals
She graduated magna cum laude from Hunter College in 1941 and began graduate studies at New York University. She later transferred to the University of Iowa where she received a Master's degree in 1944 and a Ph.D in 1946


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Emil Witschi grad student 1946 University of Iowa
 (Effects of testosterone propionate on sex development in female Ambystoma larvae)
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Mintz B, Silvers WK. (2007) "Intrinsic" immunological tolerance in allophenic mice. 1967. Journal of Immunology (Baltimore, Md. : 1950). 178: 4007-10
Milling SW, Sai T, Silvers WK, et al. (2004) Inhibition of melanoma growth after treatment with dendritic cells in a Tyr-SV40E murine model requires CD4+ T cells but not CD8+ T cells. Melanoma Research. 14: 555-62
Blelloch RH, Hochedlinger K, Yamada Y, et al. (2004) Nuclear cloning of embryonal carcinoma cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 13985-90
Sai T, Milling SW, Mintz B. (2002) Freezing and thawing of bone marrow-derived murine dendritic cells with subsequent retention of immunophenotype and of antigen processing and presentation characteristics. Journal of Immunological Methods. 264: 153-62
Milling SW, Silvers WK, Sai T, et al. (2002) Decline in MHC class I expression with increasing thickness of cutaneous melanomas in standard-strain transgenic mouse models. Melanoma Research. 12: 221-30
Kelsall SR, Mintz B. (1998) Metastatic cutaneous melanoma promoted by ultraviolet radiation in mice with transgene-initiated low melanoma susceptibility. Cancer Research. 58: 4061-5
Orlow SJ, Silvers WK, Zhou BK, et al. (1998) Comparative decreases in tyrosinase, TRP-1, TRP-2, and Pmel 17/silver antigenic proteins from melanotic to amelanotic stages of syngeneic mouse cutaneous melanomas and metastases. Cancer Research. 58: 1521-3
Silvers WK, Mintz B. (1998) Differences in latency and inducibility of mouse skin melanomas depending on the age and anatomic site of the skin. Cancer Research. 58: 630-2
Kelsall SR, Le Fur N, Mintz B. (1997) Qualitative and quantitative catalog of tyrosinase alternative transcripts in normal murine skin melanocytes as a basis for detecting melanoma-specific changes. Biochemical and Biophysical Research Communications. 236: 173-7
Le Fur N, Silvers WK, Kelsall SR, et al. (1997) Up-regulation of specific tyrosinase mRNAs in mouse melanomas with the c2j gene substituted for the wild-type tyrosinase allele: utilization in design of syngeneic immunotherapy models. Proceedings of the National Academy of Sciences of the United States of America. 94: 7561-5
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