|California Institute of Technology, Pasadena, CA|
(1906 - 1968)
An Appreciation of Albert Tyler 1906 1968
Albert Tyler (June 26, 1906—1968) was an American biologist whose research was focused on reproductive biology and development in marine organisms.
Tyler was born in Brooklyn, New York. He attended Columbia University majoring in chemistry. When he started graduate studies he took interest in the work of Thomas Hunt Morgan. Morgan took Tyler, and several other graduate students and research fellows with him, to the California Institute of Technology when he was hired to establish the new Division of Biology. Tyler completed his Ph.D. studies on reproductive biology and was appointed to the faculty at Caltech.
Tyler's research looked at development and differentiation of embryos from a range of marine organisms. He made early use of immunohistochemical techniques and was one of the first researchers to recognize that maternal messenger RNA present in the ovum could affect differentiation. His research on nucleic acid and protein synthesis in sea urchin eggs was cut short when he died unexpectedly in 1968.
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|Diede SJ, Yao Z, Keyes CC, et al. (2013) Fundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer. Epigenetics : Official Journal of the Dna Methylation Society. 8: 1254-60|
|Parker MH, Loretz C, Tyler AE, et al. (2012) Activation of Notch signaling during ex vivo expansion maintains donor muscle cell engraftment. Stem Cells (Dayton, Ohio). 30: 2212-20|
|Block GJ, Petek LM, Narayanan D, et al. (2012) Asymmetric bidirectional transcription from the FSHD-causing D4Z4 array modulates DUX4 production. Plos One. 7: e35532|
|Parker MH, Loretz C, Tyler AE, et al. (2012) Inhibition of CD26/DPP-IV enhances donor muscle cell engraftment and stimulates sustained donor cell proliferation. Skeletal Muscle. 2: 4|
|Geng LN, Tyler AE, Tapscott SJ. (2011) Immunodetection of human double homeobox 4. Hybridoma (2005). 30: 125-30|
|Maves L, Tyler A, Moens CB, et al. (2009) Pbx acts with Hand2 in early myocardial differentiation. Developmental Biology. 333: 409-18|
|Snider L, Asawachaicharn A, Tyler AE, et al. (2009) RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy. Human Molecular Genetics. 18: 2414-30|
|Maves L, Waskiewicz AJ, Paul B, et al. (2007) Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation. Development (Cambridge, England). 134: 3371-82|
|Piatigorsky J, Ozaki H, Tyler A. (1967) RNA-and protein-synthesizing capacity of isolated oocytes of the sea urchin Lytechinus pictus. Developmental Biology. 15: 1-22|
|Tyler A, Piatigorsky J, Ozaki H. (1966) Influence of individual amino acids on uptake and incorporation of valine, glutamic acid and arginine by unfertilized and fertilized sea urchin eggs. The Biological Bulletin. 131: 204-17|