Wouter de Laat
Affiliations: | Erasmus Medical Center Rotterdam, Rotterdam, Netherlands |
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"Wouter de Laat"Parents
Sign in to add mentor| Jan Hoeijmakers | grad student | 1993-1998 | Erasmus University |
| Frank Grosveld | post-doc | 1998-2000 | Erasmus MC |
Children
Sign in to add trainee| Daan Noordermeer | grad student | 2003-2009 | Erasmus MC |
| Elzo de Wit | post-doc | 2007-2015 | Hubrecht Institute (GenetiTree) |
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Publications
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| Huang Y, Verstegen MJAM, Tjalsma SJD, et al. (2025) Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain. Genes & Development |
| Venema WJ, Hiddingh S, van Loosdregt J, et al. (2023) A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs. Cell Genomics. 100460 |
| Rinzema NJ, Sofiadis K, Tjalsma SJD, et al. (2022) Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes. Nature Structural & Molecular Biology. 29: 563-574 |
| Bellefroid M, Rodari A, Galais M, et al. (2022) Role of the cellular factor CTCF in the regulation of bovine leukemia virus latency and three-dimensional chromatin organization. Nucleic Acids Research. 50: 3190-3202 |
| Vos ESM, Valdes-Quezada C, Huang Y, et al. (2021) Interplay between CTCF boundaries and a super enhancer controls cohesin extrusion trajectories and gene expression. Molecular Cell |
| Tjalsma SJ, de Laat W. (2020) Novel orthogonal methods to uncover the complexity and diversity of nuclear architecture. Current Opinion in Genetics & Development. 67: 10-17 |
| Hall AW, Chaffin M, Roselli C, et al. (2020) Epigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial Fibrillation. Circulation. Genomic and Precision Medicine |
| Man JC, van Duijvenboden K, Krijger PH, et al. (2020) Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart. Circulation Research |
| Huang Y, Neijts R, de Laat W. (2020) How chromosome topologies get their shape: views from proximity ligation and microscopy methods. Febs Letters |
| van Ouwerkerk AF, Hall AW, Kadow ZA, et al. (2020) Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation. Circulation Research. 127: 34-50 |