Richard Klinghoffer

Affiliations: 
1998-2001 Fred Hutchinson Cancer Research Center, Seattle, WA, United States 
 2010- Presage Biosciences 
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"Richard Klinghoffer"
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Kerwin WS, Tretyak I, Grenley MO, et al. (2015) Minimally invasive in tumor multidrug comparative analysis with contrast-enhanced MRI in mice. Magnetic Resonance in Medicine
Chen N, Brachmann C, Liu X, et al. (2015) Albumin-bound nanoparticle (nab) paclitaxel exhibits enhanced paclitaxel tissue distribution and tumor penetration. Cancer Chemotherapy and Pharmacology
Klinghoffer RA, Bahrami SB, Hatton BA, et al. (2015) A technology platform to assess multiple cancer agents simultaneously within a patient's tumor. Science Translational Medicine. 7: 284ra58
Di Cosimo S, Sathyanarayanan S, Bendell JC, et al. (2015) Combination of the mTOR inhibitor ridaforolimus and the anti-IGF1R monoclonal antibody dalotuzumab: preclinical characterization and phase I clinical trial. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 49-59
Klinghoffer RA, Magnus J, Schelter J, et al. (2010) Reduced seed region-based off-target activity with lentivirus-mediated RNAi Rna. 16: 879-884
Klinghoffer RA, Frazier J, Annis J, et al. (2009) A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling. Plos One. 4: e6892
Klinghoffer RA, Roberts B, Annis J, et al. (2008) An optimized lentivirus-mediated RNAi screen reveals kinase modulators of kinesin-5 inhibitor sensitivity. Assay and Drug Development Technologies. 6: 105-19
Hamilton TG, Klinghoffer RA, Corrin PD, et al. (2003) Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms Molecular and Cellular Biology. 23: 4013-4025
Cary LA, Klinghoffer RA, Sachsenmaier C, et al. (2002) Src catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading Molecular and Cellular Biology. 22: 2427-2440
Klinghoffer RA, Hamilton TG, Hoch R, et al. (2002) An allelic series at the PDGFαR locus indicates unequal contributions of distinct signaling pathways during development Developmental Cell. 2: 103-113
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