Peter J. Mohler, Ph.D. - Publications

Affiliations: 
University of North Carolina, Chapel Hill, Chapel Hill, NC 

192 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 El Refaey M, Coles S, Musa H, Stevens TL, Wallace MJ, Murphy NP, Antwi-Boasiako S, Young LJ, Manring HR, Curran J, Makara MA, Sas K, Han M, Koenig SN, Skaf M, ... ... Mohler PJ, et al. Altered Expression of Zonula occludens-1 Affects Cardiac Na Channels and Increases Susceptibility to Ventricular Arrhythmias. Cells. 11. PMID 35203314 DOI: 10.3390/cells11040665  0.32
2021 Cavus O, Williams J, Musa H, El Refaey M, Gratz D, Shaheen R, Schwieterman NA, Koenig S, Antwi-Boasiako S, Young LJ, Xu X, Han M, Wold LE, Hund TJ, Mohler PJ, et al. Giant ankyrin-G regulates cardiac function. The Journal of Biological Chemistry. 100507. PMID 33675749 DOI: 10.1016/j.jbc.2021.100507  0.326
2020 Comelli M, Meo M, Cervantes DO, Pizzo E, Plosker A, Mohler PJ, Hund TJ, Jacobson JT, Meste O, Rota M. Rhythm Dynamics of the Aging Heart: an Experimental Study Using Conscious, Restrained Mice. American Journal of Physiology. Heart and Circulatory Physiology. PMID 32886003 DOI: 10.1152/Ajpheart.00379.2020  0.335
2020 Yanni J, D'Souza A, Wang Y, Li N, Hansen BJ, Zakharkin SO, Smith M, Hayward C, Whitson BA, Mohler PJ, Janssen PML, Zeef L, Choudhury M, Zi M, Cai X, et al. Silencing miR-370-3p rescues funny current and sinus node function in heart failure. Scientific Reports. 10: 11279. PMID 32647133 DOI: 10.1038/S41598-020-67790-0  0.306
2020 Stevens TL, Wallace MJ, Refaey ME, Roberts JD, Koenig SN, Mohler PJ. Arrhythmogenic Cardiomyopathy: Molecular Insights for Improved Therapeutic Design. Journal of Cardiovascular Development and Disease. 7. PMID 32466575 DOI: 10.3390/Jcdd7020021  0.339
2020 Musa H, Marcou CA, Herron TJ, Makara M, Tester DJ, O'Connell R, Rosinski B, Guerrero-Serna G, Milstein ML, Monteiro Da Rocha A, Ye D, Crotti L, Nesterenko VV, Castelletti S, Torchio M, ... ... Mohler PJ, et al. Abnormal myocardial expression of SAP97 is associated with arrhythmogenic risk. American Journal of Physiology. Heart and Circulatory Physiology. PMID 32196358 DOI: 10.1152/Ajpheart.00481.2019  0.432
2020 Murphy NP, Lubbers E, Mohler PJ. Advancing our understanding of AnkRD1 in cardiac development and disease. Cardiovascular Research. PMID 32186710 DOI: 10.1093/Cvr/Cvaa063  0.327
2020 Misra C, Bangru S, Lin F, Lam K, Koenig SN, Lubbers ER, Hedhli J, Murphy NP, Parker DJ, Dobrucki LW, Cooper TA, Tajkhorshid E, Mohler PJ, Kalsotra A. Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy. Developmental Cell. PMID 32109384 DOI: 10.1016/J.Devcel.2020.01.037  0.386
2020 Unudurthi SD, Nassal DM, Patel NJ, Thomas E, Yu J, Pierson CG, Bansal SS, Mohler PJ, Hund TJ. Fibroblast growth factor-inducible 14 mediates macrophage infiltration in heart to promote pressure overload-induced cardiac dysfunction. Life Sciences. 117440. PMID 32070706 DOI: 10.1016/J.Lfs.2020.117440  0.331
2020 Liu CH, Stevens SR, Teliska LH, Stankewich M, Mohler PJ, Hund TJ, Rasband MN. Nodal β spectrins are required to maintain Na channel clustering and axon integrity. Elife. 9. PMID 32052742 DOI: 10.7554/Elife.52378  0.3
2020 Sucharski HC, Dudley EK, Keith CBR, El Refaey M, Koenig SN, Mohler PJ. Mechanisms and Alterations of Cardiac Ion Channels Leading to Disease: Role of Ankyrin-B in Cardiac Function. Biomolecules. 10. PMID 32023981 DOI: 10.3390/biom10020211  0.342
2020 Li N, Kalyanasundaram A, Hansen BJ, Artiga EJ, Sharma R, Abudulwahed SH, Helfrich KM, Rozenberg G, Wu PJ, Zakharkin S, Gyorke S, Janssen PM, Whitson BA, Mokadam NA, Biesiadecki BJ, ... ... Mohler PJ, et al. Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node. Nature Communications. 11: 512. PMID 31980605 DOI: 10.1038/S41467-019-14039-8  0.38
2019 Long VP, Bonilla IM, Baine S, Glynn P, Kumar S, Schober K, Mowrey K, Weiss R, Lee NY, Mohler PJ, Györke S, Hund TJ, Fedorov VV, Carnes CA. Chronic heart failure increases negative chronotropic effects of adenosine in canine sinoatrial cells via A1R stimulation and GIRK-mediated I. Life Sciences. 117068. PMID 31751583 DOI: 10.1016/J.Lfs.2019.117068  0.311
2019 Lubbers ER, Murphy NP, Musa H, Huang CY, Gupta R, Price MV, Han M, Daoud GE, Gratz D, El Refaey M, Xu X, Hoeflinger NK, Friel EL, Lancione P, Wallace MJ, ... ... Mohler PJ, et al. Correction: Defining new mechanistic roles for α II spectrin in cardiac function. The Journal of Biological Chemistry. 294: 15557. PMID 31628198 DOI: 10.1074/Jbc.Aac119.011151  0.309
2019 Greer-Short A, Musa H, Alsina KM, Ni L, Word TA, Reynolds JO, Gratz D, Lane C, El-Refaey M, Unudurthi S, Skaf M, Li N, Fedorov VV, Wehrens XHT, Mohler PJ, et al. Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling and atrial arrhythmia. Heart Rhythm. PMID 31622781 DOI: 10.1016/J.Hrthm.2019.10.016  0.34
2019 Patel NJ, Nassal DM, Greer-Short AD, Unudurthi SD, Scandling BW, Gratz D, Xu X, Kalyanasundaram A, Fedorov VV, Accornero F, Mohler PJ, Gooch KJ, Hund TJ. βIV-spectrin/STAT3 complex regulates fibroblast phenotype, fibrosis and cardiac function. Jci Insight. PMID 31550236 DOI: 10.1172/Jci.Insight.131046  0.378
2019 van Opbergen CJM, Noorman M, Pfenniger A, Copier JS, Vermij SH, Li Z, van der Nagel R, Zhang M, de Bakker JMT, Glass AM, Mohler PJ, Taffet SM, Vos MA, van Rijen HVM, Delmar M, et al. Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress. International Journal of Molecular Sciences. 20. PMID 31438494 DOI: 10.3390/Ijms20174076  0.389
2019 Chung JH, Milani-Nejad N, Davis JP, Weisleder N, Whitson BA, Mohler PJ, Janssen PML. Impact of heart rate on cross-bridge cycling kinetics in failing and non-failing human myocardium. American Journal of Physiology. Heart and Circulatory Physiology. PMID 31347914 DOI: 10.1152/Ajpheart.00163.2019  0.348
2019 Lorenzo DN, Badea A, Zhou R, Mohler PJ, Zhuang X, Bennett V. βII-spectrin promotes mouse brain connectivity through stabilizing axonal plasma membranes and enabling axonal organelle transport. Proceedings of the National Academy of Sciences of the United States of America. PMID 31209033 DOI: 10.1073/Pnas.1820649116  0.741
2019 Lubbers ER, Murphy NP, Musa H, Huang CY, Gupta R, Price MV, Han M, Daoud GE, Gratz D, El Refaey M, Xu X, Hoeflinger NK, Friel EL, Lancione P, Wallace MJ, ... ... Mohler PJ, et al. Defining new mechanistic roles for αII spectrin in cardiac function. The Journal of Biological Chemistry. PMID 31064843 DOI: 10.1074/Jbc.Ra119.007714  0.332
2019 El Refaey M, Musa H, Smith SA, Binkley PF, Bradley E, Hund TJ, Mohler PJ. Response by El Refaey et al to Letter Regarding Article, "Protein Phosphatase 2A Regulates Cardiac Na Channels". Circulation Research. 124: e60-e61. PMID 30973807 DOI: 10.1161/Circresaha.119.314938  0.31
2019 Chen MP, Kiduko SA, Saad NS, Canan BD, Kilic A, Mohler PJ, Janssen PML. Stretching Single Titin Molecules from Failing Human Hearts Reveals Titin's Role in Blunting Cardiac Kinetic Reserve. Cardiovascular Research. PMID 30778519 DOI: 10.1093/Cvr/Cvz043  0.358
2019 Patel NJ, Nassal DM, Scandling BW, Greer-Short AD, Unudurthi SD, Xu X, Mohler PJ, Gooch KJ, Hund TJ. Abstract 844: β IV -spectrin Regulates Cardiac Fibroblast Phenotype, Fibrosis, and Cardiac Function Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.844  0.352
2018 Zhu W, Wang C, Hu J, Wan R, Yu J, Xie J, Ma J, Guo L, Ge J, Qiu Y, Chen L, Liu H, Yan X, Liu X, Ye J, ... ... Mohler PJ, et al. Ankyrin-B Q1283H Variant Linked to Arrhythmias Via Loss of Local Protein Phosphatase 2A Activity Causes Ryanodine Receptor Hyperphosphorylation. Circulation. 138: 2682-2697. PMID 30571258 DOI: 10.1161/Circulationaha.118.034541  0.384
2018 Saad NS, Elnakish MT, Brundage EA, Biesiadecki BJ, Kilic A, Ahmed AAE, Mohler PJ, Janssen PML. Assessment of PKA and PKC inhibitors on force and kinetics of non-failing and failing human myocardium. Life Sciences. PMID 30399377 DOI: 10.1016/J.Lfs.2018.10.065  0.365
2018 Yoo S, Aistrup G, Shiferaw Y, Ng J, Mohler PJ, Hund TJ, Waugh T, Browne S, Gussak G, Gilani M, Knight BP, Passman R, Goldberger JJ, Wasserstrom JA, Arora R. Oxidative stress creates a unique, CaMKII-mediated substrate for atrial fibrillation in heart failure. Jci Insight. 3. PMID 30385719 DOI: 10.1172/Jci.Insight.120728  0.357
2018 Unudurthi SD, Nassal DM, Greer-Short A, Patel NJ, Howard T, Xu X, Onal B, Satroplus T, Hong DY, Lane CM, Dalic A, Koenig SN, Lehnig AC, Baer LA, Musa H, ... ... Mohler PJ, et al. βIV-spectrin regulates STAT3 targeting to tune cardiac response to pressure overload. The Journal of Clinical Investigation. PMID 30226828 DOI: 10.1172/Jci99245  0.4
2018 Chung JH, Martin BL, Canan BD, Elnakish MT, Milani-Nejad N, Saad NS, Repas SJ, Schultz JEJ, Murray JD, Slabaugh JL, Gearinger RL, Conkle J, Karaze T, Rastogi N, Chen MP, ... ... Mohler PJ, et al. Etiology-dependent impairment of relaxation kinetics in right ventricular end-stage failing human myocardium. Journal of Molecular and Cellular Cardiology. PMID 29981798 DOI: 10.1016/J.Yjmcc.2018.07.005  0.317
2018 Howard T, Greer-Short A, Satroplus T, Patel N, Nassal D, Mohler PJ, Hund TJ. CaMKII-dependent late sodium current increases electrical dispersion and arrhythmia in ischemia/reperfusion. American Journal of Physiology. Heart and Circulatory Physiology. PMID 29932771 DOI: 10.1152/Ajpheart.00197.2018  0.352
2018 Kempton A, Cefalu M, Justice C, Baich T, Derbala M, Canan B, Janssen PML, Mohler PJ, Smith SA. Altered regulation of cardiac ankyrin repeat protein in heart failure. Heliyon. 4: e00514. PMID 29560432 DOI: 10.1016/J.Heliyon.2018.E00514  0.367
2018 Dun W, Danilo P, Mohler PJ, Boyden PA. Microtubular remodeling and decreased expression of Nav1.5 with enhanced EHD4 in cells from the infarcted heart. Life Sciences. PMID 29534991 DOI: 10.1016/J.Lfs.2018.03.024  0.414
2018 Williams JL, Cavus O, Loccoh EC, Adelman S, Daugherty JC, Smith SA, Canan B, Janssen PML, Koenig S, Kline CF, Mohler PJ, Bradley EA. Defining the molecular signatures of human right heart failure. Life Sciences. PMID 29366750 DOI: 10.1016/J.Lfs.2018.01.021  0.315
2018 MISRA C, BANGRU S, PARKER DJ, KOENIG S, LUBBERS E, HEDHLI J, COOPER TA, DOBRUCKI WL, MOHLER P, KALSOTRA A. Abstract 520: Overexpression of a Non-muscle RBFOX2 Splice Isoform Induce Cardiac Arrhythmias in Myotonic Dystrophy Circulation Research. 123. DOI: 10.1161/Res.123.Suppl_1.520  0.32
2017 El Refaey MM, Mohler PJ. Ankyrins and Spectrins in Cardiovascular Biology and Disease. Frontiers in Physiology. 8: 852. PMID 29163198 DOI: 10.3389/Fphys.2017.00852  0.439
2017 Milani-Nejad N, Chung JH, Canan BD, Fedorov VV, Whitson BA, Kilic A, Mohler PJ, Janssen PML. Increased cross-bridge recruitment contributes to transient increase in force generation beyond maximal capacity in human myocardium. Journal of Molecular and Cellular Cardiology. PMID 29141185 DOI: 10.1016/J.Yjmcc.2017.11.007  0.311
2017 Derbala MH, Guo AS, Mohler PJ, Smith SA. The role of βII spectrin in cardiac health and disease. Life Sciences. PMID 29128512 DOI: 10.1016/J.Lfs.2017.11.009  0.426
2017 Mohler PJ, Hund TJ. Novel Pathways for Regulation of Sinoatrial Node Plasticity and Heart Rate. Circulation Research. 121: 1027-1028. PMID 29025753 DOI: 10.1161/Circresaha.117.311922  0.388
2017 Zhao J, Hansen BJ, Wang Y, Csepe TA, Sul LV, Tang A, Yuan Y, Li N, Bratasz A, Powell KA, Kilic A, Mohler PJ, Janssen PML, Weiss R, Simonetti OP, et al. Three-dimensional Integrated Functional, Structural, and Computational Mapping to Define the Structural "Fingerprints" of Heart-Specific Atrial Fibrillation Drivers in Human Heart Ex Vivo. Journal of the American Heart Association. 6. PMID 28862969 DOI: 10.1161/Jaha.117.005922  0.319
2017 El Refaey M, Xu L, Gao Y, Canan BD, Adesanya TA, Warner SC, Akagi K, Symer DE, Mohler PJ, Ma J, Janssen PM, Han R. In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice. Circulation Research. PMID 28790199 DOI: 10.1161/Circresaha.117.310996  0.35
2017 Koenig SN, Mohler PJ. The Evolving Role of Ankyrin-B in Cardiovascular Disease. Heart Rhythm. PMID 28765088 DOI: 10.1016/J.Hrthm.2017.07.032  0.412
2017 Li N, Hansen BJ, Csepe TA, Zhao J, Ignozzi AJ, Sul LV, Zakharkin SO, Kalyanasundaram A, Davis JP, Biesiadecki BJ, Kilic A, Janssen PML, Mohler PJ, Weiss R, Hummel JD, et al. Redundant and diverse intranodal pacemakers and conduction pathways protect the human sinoatrial node from failure. Science Translational Medicine. 9. PMID 28747516 DOI: 10.1126/Scitranslmed.Aam5607  0.366
2017 Boyden PA, Mohler PJ. Treat the Patient, Not Just the Cell! Circulation Research. 120: 1390-1392. PMID 28450361 DOI: 10.1161/Circresaha.116.310427  0.396
2017 Swayne LA, Murphy NP, Asuri S, Chen L, Xu X, McIntosh S, Wang C, Lancione PJ, Roberts JD, Kerr C, Sanatani S, Sherwin E, Kline CF, Zhang M, Mohler PJ, et al. Novel Variant in the ANK2 Membrane-Binding Domain Is Associated With Ankyrin-B Syndrome and Structural Heart Disease in a First Nations Population With a High Rate of Long QT Syndrome. Circulation. Cardiovascular Genetics. 10. PMID 28196901 DOI: 10.1161/Circgenetics.116.001537  0.325
2017 Chen M, Saad NS, Canan BD, Kilic A, Mohler PJ, Janssen PM. A Novel Approach to Identify the Role of Single Molecule Titin Mechanics in Human Heart Failure Biophysical Journal. 112: 121a. DOI: 10.1016/J.Bpj.2016.11.678  0.381
2016 Huq AJ, Pertile MD, Davis AM, Landon H, James PA, Kline CF, Vohra J, Mohler PJ, Delatycki MB. A Novel Mechanism for Human Cardiac Ankyrin-B Syndrome due to Reciprocal Chromosomal Translocation. Heart, Lung & Circulation. PMID 27916589 DOI: 10.1016/j.hlc.2016.09.013  0.314
2016 Elnakish MT, Canan BD, Kilic A, Mohler PJ, Janssen PM. Effects of Zacopride, a Moderate IK1 channel agonist, on Triggered Arrhythmia and Contractility in Human Ventricular Myocardium. Pharmacological Research. PMID 27914945 DOI: 10.1016/J.Phrs.2016.11.033  0.386
2016 Radwański PB, Ho HT, Veeraraghavan R, Brunello L, Liu B, Belevych AE, Unudurthi SD, Makara MA, Priori SG, Volpe P, Armoundas AA, Dillmann WH, Knollmann BC, Mohler PJ, Hund TJ, et al. Neuronal Na(+) Channels Are Integral Components of Pro-arrhythmic Na(+)/Ca(2+) Signaling Nanodomain That Promotes Cardiac Arrhythmias During β-adrenergic Stimulation. Jacc. Basic to Translational Science. 1: 251-266. PMID 27747307 DOI: 10.1016/J.Jacbts.2016.04.004  0.37
2016 Hund TJ, Mohler PJ. Atrial-specific pathways for control of intracellular signaling and myocyte function. The Journal of Clinical Investigation. PMID 27643440 DOI: 10.1172/Jci90348  0.351
2016 Makara MA, Hoang KV, Ganesan LP, Crouser ED, Gunn JS, Turner J, Schlesinger LS, Mohler PJ, Rajaram MV. Cardiac Electrical and Structural Changes During Bacterial Infection: An Instructive Model to Study Cardiac Dysfunction in Sepsis. Journal of the American Heart Association. 5. PMID 27620887 DOI: 10.1161/Jaha.116.003820  0.333
2016 Li N, Csepe TA, Hansen BJ, Sul LV, Kalyanasundaram A, Zakharkin SO, Zhao J, Guha A, Van Wagoner DR, Kilic A, Mohler PJ, Janssen PM, Biesiadecki B, Hummel JD, Weiss R, et al. Adenosine-Induced Atrial Fibrillation: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart. Circulation. PMID 27462069 DOI: 10.1161/Circulationaha.115.021165  0.31
2016 Musa H, Murphy NP, Curran J, Higgins JD, Webb TR, Makara MA, Wright P, Lancione PJ, Lubbers ER, Healy JA, Smith SA, Bennett V, Hund TJ, Kline CF, Mohler PJ. Common human ANK2 variant confers in vivo arrhythmia phenotypes. Heart Rhythm : the Official Journal of the Heart Rhythm Society. PMID 27298202 DOI: 10.1016/J.Hrthm.2016.06.012  0.728
2016 Popescu I, Galice S, Mohler PJ, Despa S. Elevated local [Ca2+] and CaMKII promote spontaneous Ca2+ release in ankyrin-B deficient hearts. Cardiovascular Research. PMID 27131508 DOI: 10.1093/Cvr/Cvw093  0.315
2016 Smith S, Hughes L, Kline CF, Kempton A, Dorn L, Curran J, Makara M, Webb T, Wright P, Voigt N, Binkley PF, Janssen PM, Kilic A, Carnes CA, Dobrev D, ... ... Mohler PJ, et al. Dysfunction of the βII spectrin-based pathway in human heart failure. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00875.2015. PMID 27106045 DOI: 10.1152/Ajpheart.00875.2015  0.417
2016 Unudurthi SD, Wu X, Qian L, Amari F, Onal B, Li N, Makara MA, Smith SA, Snyder J, Fedorov VV, Coppola V, Anderson ME, Mohler PJ, Hund TJ. Two-Pore K+ Channel TREK-1 Regulates Sinoatrial Node Membrane Excitability. Journal of the American Heart Association. 5. PMID 27098968 DOI: 10.1161/Jaha.115.002865  0.352
2016 Saad NS, Floyd K, Ahmed AA, Mohler PJ, Janssen PM, Elnakish MT. The Effect of Sorafenib, Tadalafil and Macitentan Treatments on Thyroxin-Induced Hemodynamic Changes and Cardiac Abnormalities. Plos One. 11: e0153694. PMID 27082116 DOI: 10.1371/Journal.Pone.0153694  0.353
2016 Mohler PJ, Abriel H. Complexity of Cardiac Ion Channel Macromolecular Complexes. Cardiovascular Research. PMID 26984855 DOI: 10.1093/Cvr/Cvw055  0.426
2016 Elnakish MT, Canan BD, Higgins RS, Kilic A, Mohler PJ, M.L. Janssen P. Zacopride, a Novel IK1 Activator, is a Potential Effective Treatment for Triggered Arrhythmia in Susceptible Human Hearts Biophysical Journal. 110: 122a. DOI: 10.1016/J.Bpj.2015.11.708  0.372
2016 Radwański PB, Ho H, Liu B, Belevych A, Armoundas A, Dillmann W, Knollmann B, Mohler P, Hund T, Györke S. Catecholaminergic Stimulation of Neuronal Na+ Channels Accounts for Triggered Arrhythmia Mechanism in CPVT Biophysical Journal. 110: 435a. DOI: 10.1016/J.Bpj.2015.11.2348  0.338
2015 Zhao J, Hansen BJ, Csepe TA, Lim P, Wang Y, Williams M, Mohler PJ, Janssen PM, Weiss R, Hummel JD, Fedorov VV. Integration of High-Resolution Optical Mapping and 3-Dimensional Micro-Computed Tomographic Imaging to Resolve the Structural Basis of Atrial Conduction in the Human Heart. Circulation. Arrhythmia and Electrophysiology. 8: 1514-7. PMID 26671938 DOI: 10.1161/Circep.115.003064  0.325
2015 Milani-Nejad N, Canan BD, Elnakish MT, Davis JP, Chung JH, Fedorov V, Binkley PF, Higgins RS, Kilic A, Mohler PJ, Janssen PM. The Frank-Starling Mechanism Involves Deceleration of Cross-Bridge Kinetics and is Preserved in Failing Human Right Ventricular Myocardium. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00685.2015. PMID 26453335 DOI: 10.1152/Ajpheart.00685.2015  0.354
2015 Roof SR, Boslett J, Russell D, Del Rio C, Alecusan J, Zweier JL, Ziolo MT, Hamlin R, Mohler PJ, Curran J. Insulin-like growth factor 1 prevents diastolic and systolic dysfunction associated with cardiomyopathy and preserves adrenergic sensitivity. Acta Physiologica (Oxford, England). PMID 26399932 DOI: 10.1111/Apha.12607  0.307
2015 Musa H, Kline CF, Sturm AC, Murphy N, Adelman S, Wang C, Yan H, Johnson BL, Csepe TA, Kilic A, Higgins RS, Janssen PM, Fedorov VV, Weiss R, Salazar C, ... ... Mohler PJ, et al. SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia. Proceedings of the National Academy of Sciences of the United States of America. 112: 12528-33. PMID 26392562 DOI: 10.1073/Pnas.1516430112  0.415
2015 Li N, Csepe TA, Hansen BJ, Dobrzynski H, Higgins RS, Kilic A, Mohler PJ, Janssen PM, Rosen MR, Biesiadecki BJ, Fedorov VV. Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart. Circulation. Arrhythmia and Electrophysiology. PMID 26304511 DOI: 10.1161/Circep.115.003070  0.342
2015 Little SC, Curran J, Makara MA, Kline CF, Ho HT, Xu Z, Wu X, Polina I, Musa H, Meadows AM, Carnes CA, Biesiadecki BJ, Davis JP, Weisleder N, Györke S, ... ... Mohler PJ, et al. Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart. Science Signaling. 8: ra72. PMID 26198358 DOI: 10.1126/Scisignal.Aaa5876  0.402
2015 Glynn P, Musa H, Wu X, Unudurthi SD, Little S, Qian L, Wright PJ, Radwanski PB, Gyorke S, Mohler PJ, Hund TJ. Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function in vivo. Circulation. PMID 26187182 DOI: 10.1161/Circulationaha.114.015218  0.362
2015 Elnakish MT, Ahmed AA, Mohler PJ, Janssen PM. Role of Oxidative Stress in Thyroid Hormone-Induced Cardiomyocyte Hypertrophy and Associated Cardiac Dysfunction: An Undisclosed Story. Oxidative Medicine and Cellular Longevity. 2015: 854265. PMID 26146529 DOI: 10.1155/2015/854265  0.32
2015 Hansen BJ, Zhao J, Csepe TA, Moore BT, Li N, Jayne LA, Kalyanasundaram A, Lim P, Bratasz A, Powell KA, Simonetti OP, Higgins RS, Kilic A, Mohler PJ, Janssen PM, et al. Atrial fibrillation driven by micro-anatomic intramural re-entry revealed by simultaneous sub-epicardial and sub-endocardial optical mapping in explanted human hearts. European Heart Journal. PMID 26059724 DOI: 10.1093/Eurheartj/Ehv233  0.303
2015 Sturm AC, Kline CF, Glynn P, Johnson BL, Curran J, Kilic A, Higgins RS, Binkley PF, Janssen PM, Weiss R, Raman SV, Fowler SJ, Priori SG, Hund TJ, Carnes CA, ... Mohler PJ, et al. Use of whole exome sequencing for the identification of Ito-based arrhythmia mechanism and therapy. Journal of the American Heart Association. 4. PMID 26015324 DOI: 10.1161/Jaha.114.001762  0.354
2015 Curran J, Musa H, Kline CF, Makara MA, Little SC, Higgins JD, Hund TJ, Band H, Mohler PJ. Eps15 Homology Domain-containing Protein 3 Regulates Cardiac T-type Ca2+ Channel Targeting and Function in the Atria. The Journal of Biological Chemistry. 290: 12210-21. PMID 25825486 DOI: 10.1074/Jbc.M115.646893  0.446
2015 Elnakish MT, Schultz EJ, Gearinger RL, Saad NS, Rastogi N, Ahmed AA, Mohler PJ, Janssen PM. Differential involvement of various sources of reactive oxygen species in thyroxin-induced hemodynamic changes and contractile dysfunction of the heart and diaphragm muscles. Free Radical Biology & Medicine. 83: 252-61. PMID 25795514 DOI: 10.1016/J.Freeradbiomed.2015.02.035  0.302
2015 Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, ... ... Mohler PJ, et al. Na+ channel function, regulation, structure, trafficking and sequestration. The Journal of Physiology. 593: 1347-60. PMID 25772290 DOI: 10.1113/Jphysiol.2014.281428  0.344
2015 Curran J, Makara MA, Mohler PJ. Endosome-based protein trafficking and Ca(2+) homeostasis in the heart. Frontiers in Physiology. 6: 34. PMID 25709583 DOI: 10.3389/Fphys.2015.00034  0.403
2015 Long VP, Bonilla IM, Vargas-Pinto P, Nishijima Y, Sridhar A, Li C, Mowrey K, Wright P, Velayutham M, Kumar S, Lee NY, Zweier JL, Mohler PJ, Györke S, Carnes CA. Heart failure duration progressively modulates the arrhythmia substrate through structural and electrical remodeling. Life Sciences. 123: 61-71. PMID 25596015 DOI: 10.1016/J.Lfs.2014.12.024  0.319
2015 Hund TJ, Mohler PJ. Role of CaMKII in cardiac arrhythmias. Trends in Cardiovascular Medicine. 25: 392-397. PMID 25577293 DOI: 10.1016/J.Tcm.2014.12.001  0.389
2015 Radwa?ski PB, Brunello L, Veeraraghavan R, Ho HT, Lou Q, Makara MA, Belevych AE, Anghelescu M, Priori SG, Volpe P, Hund TJ, Janssen PM, Mohler PJ, Bridge JH, Poelzing S, et al. Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release. Cardiovascular Research. 106: 143-52. PMID 25538156 DOI: 10.1093/Cvr/Cvu262  0.354
2015 Swager SA, Delfín DA, Rastogi N, Wang H, Canan BD, Fedorov VV, Mohler PJ, Kilic A, Higgins RS, Ziolo MT, Janssen PM, Rafael-Fortney JA. Claudin-5 levels are reduced from multiple cell types in human failing hearts and are associated with mislocalization of ephrin-B1. Cardiovascular Pathology : the Official Journal of the Society For Cardiovascular Pathology. 24: 160-7. PMID 25440958 DOI: 10.1016/J.Carpath.2014.10.006  0.394
2015 Curran J, Mohler PJ. Alternative paradigms for ion channelopathies: disorders of ion channel membrane trafficking and posttranslational modification. Annual Review of Physiology. 77: 505-24. PMID 25293528 DOI: 10.1146/Annurev-Physiol-021014-071838  0.313
2015 Glukhov AV, Kalyanasundaram A, Lou Q, Hage LT, Hansen BJ, Belevych AE, Mohler PJ, Knollmann BC, Periasamy M, Györke S, Fedorov VV. Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex1. European Heart Journal. 36: 686-97. PMID 24216388 DOI: 10.1093/Eurheartj/Eht452  0.335
2015 Grueter CE, Abiria SA, Dzhura I, Wu Y, Ham AJL, Mohler PJ, Anderson ME, Colbran RJ. Retraction Notice To: L-Type Ca2+ Channel Facilitation Mediated by Phosphorylation of the β Subunit by CaMKII [Molecular Cell 23 (2006) 641-650] Molecular Cell. 58: 388. DOI: 10.1016/J.Molcel.2015.04.007  0.301
2014 Chang KJ, Zollinger DR, Susuki K, Sherman DL, Makara MA, Brophy PJ, Cooper EC, Bennett V, Mohler PJ, Rasband MN. Glial ankyrins facilitate paranodal axoglial junction assembly. Nature Neuroscience. 17: 1673-81. PMID 25362471 DOI: 10.1038/Nn.3858  0.539
2014 Bonilla IM, Long VP, Vargas-Pinto P, Wright P, Belevych A, Lou Q, Mowrey K, Yoo J, Binkley PF, Fedorov VV, Györke S, Janssen PM, Kilic A, Mohler PJ, Carnes CA. Calcium-activated potassium current modulates ventricular repolarization in chronic heart failure. Plos One. 9: e108824. PMID 25271970 DOI: 10.1371/Journal.Pone.0108824  0.363
2014 Makara MA, Curran J, Little SC, Musa H, Polina I, Smith SA, Wright PJ, Unudurthi SD, Snyder J, Bennett V, Hund TJ, Mohler PJ. Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo. Circulation Research. 115: 929-38. PMID 25239140 DOI: 10.1161/Circresaha.115.305154  0.612
2014 Dun W, Wright P, Danilo P, Mohler PJ, Boyden PA. SAP97 and cortactin remodeling in arrhythmogenic Purkinje cells. Plos One. 9: e106830. PMID 25184222 DOI: 10.1371/Journal.Pone.0106830  0.363
2014 Hund TJ, Mohler PJ. Nav channel complex heterogeneity: new targets for the treatment of arrhythmia? Circulation. 130: 132-4. PMID 24895456 DOI: 10.1161/Circulationaha.114.010867  0.391
2014 Lou Q, Hansen BJ, Fedorenko O, Csepe TA, Kalyanasundaram A, Li N, Hage LT, Glukhov AV, Billman GE, Weiss R, Mohler PJ, Györke S, Biesiadecki BJ, Carnes CA, Fedorov VV. Upregulation of adenosine A1 receptors facilitates sinoatrial node dysfunction in chronic canine heart failure by exacerbating nodal conduction abnormalities revealed by novel dual-sided intramural optical mapping. Circulation. 130: 315-24. PMID 24838362 DOI: 10.1161/Circulationaha.113.007086  0.333
2014 Dybkova N, Wagner S, Backs J, Hund TJ, Mohler PJ, Sowa T, Nikolaev VO, Maier LS. Tubulin polymerization disrupts cardiac β-adrenergic regulation of late INa. Cardiovascular Research. 103: 168-77. PMID 24812278 DOI: 10.1093/Cvr/Cvu120  0.369
2014 Curran J, Makara MA, Little SC, Musa H, Liu B, Wu X, Polina I, Alecusan JS, Wright P, Li J, Billman GE, Boyden PA, Gyorke S, Band H, Hund TJ, ... Mohler PJ, et al. EHD3-dependent endosome pathway regulates cardiac membrane excitability and physiology. Circulation Research. 115: 68-78. PMID 24759929 DOI: 10.1161/Circresaha.115.304149  0.395
2014 Vreeker A, van Stuijvenberg L, Hund TJ, Mohler PJ, Nikkels PG, van Veen TA. Assembly of the cardiac intercalated disk during pre- and postnatal development of the human heart. Plos One. 9: e94722. PMID 24733085 DOI: 10.1371/Journal.Pone.0094722  0.395
2014 Curran J, Tang L, Roof SR, Velmurugan S, Millard A, Shonts S, Wang H, Santiago D, Ahmad U, Perryman M, Bers DM, Mohler PJ, Ziolo MT, Shannon TR. Nitric oxide-dependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation. Plos One. 9: e87495. PMID 24498331 DOI: 10.1371/Journal.Pone.0087495  0.313
2014 Hund TJ, Snyder JS, Wu X, Glynn P, Koval OM, Onal B, Leymaster ND, Unudurthi SD, Curran J, Camardo C, Wright PJ, Binkley PF, Anderson ME, Mohler PJ. β(IV)-Spectrin regulates TREK-1 membrane targeting in the heart. Cardiovascular Research. 102: 166-75. PMID 24445605 DOI: 10.1093/Cvr/Cvu008  0.376
2014 Barry J, Gu Y, Jukkola P, O'Neill B, Gu H, Mohler PJ, Rajamani KT, Gu C. Ankyrin-G directly binds to kinesin-1 to transport voltage-gated Na+ channels into axons. Developmental Cell. 28: 117-31. PMID 24412576 DOI: 10.1016/J.Devcel.2013.11.023  0.307
2014 Kline CF, Scott J, Curran J, Hund TJ, Mohler PJ. Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting. The Journal of Biological Chemistry. 289: 5285-95. PMID 24394417 DOI: 10.1074/Jbc.M113.523639  0.399
2014 Kline CF, Mohler PJ. Defective interactions of protein partner with ion channels and transporters as alternative mechanisms of membrane channelopathies. Biochimica Et Biophysica Acta. 1838: 723-30. PMID 23732236 DOI: 10.1016/J.Bbamem.2013.05.024  0.347
2014 Curran J, Little S, Makara M, Wu X, Polina I, Wright PJ, Liu B, Gyorke S, Hund TJ, Mohler PJ. EHD3 Mediates Integral Membrane Protein Trafficking and Maintain Electrical Excitability and Adrenergic Responsiveness in the Heart Biophysical Journal. 106: 526a-527a. DOI: 10.1016/J.Bpj.2013.11.2938  0.432
2014 Milani-Nejad N, Davis JP, Fedorov VV, Mohler PJ, Kilic A, Higgins RS, Janssen PM. Existence of Length-Dependent Modulation of Cross-Bridge Cycling Kinetics in Right Ventricles of Non-Failing and Failing Human Myocardium Biophysical Journal. 106: 348a. DOI: 10.1016/J.Bpj.2013.11.1981  0.349
2013 Kline CF, Mohler PJ. Evolving form to fit function: cardiomyocyte intercalated disc and transverse-tubule membranes. Current Topics in Membranes. 72: 121-58. PMID 24210429 DOI: 10.1016/B978-0-12-417027-8.00004-0  0.37
2013 Dun W, Lowe JS, Wright P, Hund TJ, Mohler PJ, Boyden PA. Ankyrin-G participates in INa remodeling in myocytes from the border zones of infarcted canine heart. Plos One. 8: e78087. PMID 24155982 DOI: 10.1371/Journal.Pone.0078087  0.377
2013 Kline CF, Wright PJ, Koval OM, Zmuda EJ, Johnson BL, Anderson ME, Hai T, Hund TJ, Mohler PJ. βIV-Spectrin and CaMKII facilitate Kir6.2 regulation in pancreatic beta cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 17576-81. PMID 24101510 DOI: 10.1073/Pnas.1314195110  0.361
2013 Little SC, Mohler PJ. TRPM4 modulates sinus node diastolic depolarization. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 10: 1690-1. PMID 23988696 DOI: 10.1016/J.Hrthm.2013.08.026  0.389
2013 Curran J, Mohler PJ. Revisiting K(+) channel-dependent electrical remodeling in the border zone. Journal of Cardiovascular Electrophysiology. 24: 1154-6. PMID 23773490 DOI: 10.1111/Jce.12189  0.415
2013 Toischer K, Hartmann N, Wagner S, Fischer TH, Herting J, Danner BC, Sag CM, Hund TJ, Mohler PJ, Belardinelli L, Hasenfuss G, Maier LS, Sossalla S. Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease. Journal of Molecular and Cellular Cardiology. 61: 111-22. PMID 23570977 DOI: 10.1016/J.Yjmcc.2013.03.021  0.373
2013 Lübkemeier I, Requardt RP, Lin X, Sasse P, Andrié R, Schrickel JW, Chkourko H, Bukauskas FF, Kim JS, Frank M, Malan D, Zhang J, Wirth A, Dobrowolski R, Mohler PJ, et al. Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels. Basic Research in Cardiology. 108: 348. PMID 23558439 DOI: 10.1007/S00395-013-0348-Y  0.406
2013 Wolf RM, Glynn P, Hashemi S, Zarei K, Mitchell CC, Anderson ME, Mohler PJ, Hund TJ. Atrial fibrillation and sinus node dysfunction in human ankyrin-B syndrome: a computational analysis. American Journal of Physiology. Heart and Circulatory Physiology. 304: H1253-66. PMID 23436330 DOI: 10.1152/Ajpheart.00734.2012  0.306
2013 Sierra A, Zhu Z, Sapay N, Sharotri V, Kline CF, Luczak ED, Subbotina E, Sivaprasadarao A, Snyder PM, Mohler PJ, Anderson ME, Vivaudou M, Zingman LV, Hodgson-Zingman DM. Regulation of cardiac ATP-sensitive potassium channel surface expression by calcium/calmodulin-dependent protein kinase II. The Journal of Biological Chemistry. 288: 1568-81. PMID 23223335 DOI: 10.1074/Jbc.M112.429548  0.357
2013 DeGrande ST, Little SC, Nixon DJ, Wright P, Snyder J, Dun W, Murphy N, Kilic A, Higgins R, Binkley PF, Boyden PA, Carnes CA, Anderson ME, Hund TJ, Mohler PJ. Molecular mechanisms underlying cardiac protein phosphatase 2A regulation in heart. The Journal of Biological Chemistry. 288: 1032-46. PMID 23204520 DOI: 10.1074/Jbc.M112.426957  0.393
2013 Noorman M, Hakim S, Kessler E, Groeneweg JA, Cox MG, Asimaki A, van Rijen HV, van Stuijvenberg L, Chkourko H, van der Heyden MA, Vos MA, de Jonge N, van der Smagt JJ, Dooijes D, Vink A, ... ... Mohler PJ, et al. Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 10: 412-9. PMID 23178689 DOI: 10.1016/J.Hrthm.2012.11.018  0.367
2013 Yamankurt G, Nguyen FT, Mohler PJ, Cunha SR. Ankyrin-based trafficking and scaffolding of membrane proteins: Implications for plasma membrane stability, formation, and specialization Journal of Proteomics and Bioinformatics. 6. DOI: 10.4172/Jpb.1000284  0.309
2013 Hansen B, Csepe T, Kalyanasundaram A, Kamalov G, Zhao J, Janssen P, Mohler P, Davies E, Weiss R, Fedorov V. Leading Reentry Circuit(s) in the Right Atrial Free Wall Underlies Adenosine-Induced Atrial Fibrillation in Coronary Perfused Human Hearts Heart Rhythm. 10: 1745. DOI: 10.1016/J.Hrthm.2013.09.025  0.324
2012 Curran J, Mohler PJ. Defining the pathways underlying the prolonged PR interval in atrioventricular conduction disease. Plos Genetics. 8: e1003154. PMID 23236297 DOI: 10.1371/Journal.Pgen.1003154  0.338
2012 DeGrande S, Nixon D, Koval O, Curran JW, Wright P, Wang Q, Kashef F, Chiang D, Li N, Wehrens XH, Anderson ME, Hund TJ, Mohler PJ. CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 9: 2034-41. PMID 23059182 DOI: 10.1016/J.Hrthm.2012.08.026  0.343
2012 Joiner ML, Koval OM, Li J, He BJ, Allamargot C, Gao Z, Luczak ED, Hall DD, Fink BD, Chen B, Yang J, Moore SA, Scholz TD, Strack S, Mohler PJ, et al. CaMKII determines mitochondrial stress responses in heart. Nature. 491: 269-73. PMID 23051746 DOI: 10.1038/Nature11444  0.306
2012 Koval OM, Snyder JS, Wolf RM, Pavlovicz RE, Glynn P, Curran J, Leymaster ND, Dun W, Wright PJ, Cardona N, Qian L, Mitchell CC, Boyden PA, Binkley PF, Li C, ... ... Mohler PJ, et al. Ca2+/calmodulin-dependent protein kinase II-based regulation of voltage-gated Na+ channel in cardiac disease. Circulation. 126: 2084-94. PMID 23008441 DOI: 10.1161/Circulationaha.112.105320  0.439
2012 Kashef F, Li J, Wright P, Snyder J, Suliman F, Kilic A, Higgins RS, Anderson ME, Binkley PF, Hund TJ, Mohler PJ. Ankyrin-B protein in heart failure: identification of a new component of metazoan cardioprotection. The Journal of Biological Chemistry. 287: 30268-81. PMID 22778271 DOI: 10.1074/Jbc.M112.368415  0.419
2012 Cerrone M, Noorman M, Lin X, Chkourko H, Liang FX, van der Nagel R, Hund T, Birchmeier W, Mohler P, van Veen TA, van Rijen HV, Delmar M. Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency. Cardiovascular Research. 95: 460-8. PMID 22764151 DOI: 10.1093/Cvr/Cvs218  0.391
2012 Smith S, Curran J, Hund TJ, Mohler PJ. Defects in cytoskeletal signaling pathways, arrhythmia, and sudden cardiac death. Frontiers in Physiology. 3: 122. PMID 22586405 DOI: 10.3389/Fphys.2012.00122  0.394
2012 Camors E, Mohler PJ, Bers DM, Despa S. Ankyrin-B reduction enhances Ca spark-mediated SR Ca release promoting cardiac myocyte arrhythmic activity. Journal of Molecular and Cellular Cardiology. 52: 1240-8. PMID 22406428 DOI: 10.1016/J.Yjmcc.2012.02.010  0.304
2012 Gudmundsson H, Curran J, Kashef F, Snyder JS, Smith SA, Vargas-Pinto P, Bonilla IM, Weiss RM, Anderson ME, Binkley P, Felder RB, Carnes CA, Band H, Hund TJ, Mohler PJ. Differential regulation of EHD3 in human and mammalian heart failure. Journal of Molecular and Cellular Cardiology. 52: 1183-90. PMID 22406195 DOI: 10.1016/J.Yjmcc.2012.02.008  0.403
2012 Jansen JA, Noorman M, Musa H, Stein M, de Jong S, van der Nagel R, Hund TJ, Mohler PJ, Vos MA, van Veen TA, de Bakker JM, Delmar M, van Rijen HV. Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 9: 600-7. PMID 22100711 DOI: 10.1016/J.Hrthm.2011.11.025  0.323
2011 Liu Y, Chen H, Ji G, Li B, Mohler PJ, Zhu Z, Yong W, Chen Z, Xu X, Xin H, Shou W. Transgenic analysis of the role of FKBP12.6 in cardiac function and intracellular calcium release. Assay and Drug Development Technologies. 9: 620-7. PMID 22087651 DOI: 10.1089/Adt.2011.0411  0.377
2011 He BJ, Joiner ML, Singh MV, Luczak ED, Swaminathan PD, Koval OM, Kutschke W, Allamargot C, Yang J, Guan X, Zimmerman K, Grumbach IM, Weiss RM, Spitz DR, Sigmund CD, ... ... Mohler PJ, et al. Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nature Medicine. 17: 1610-8. PMID 22081025 DOI: 10.1038/Nm.2506  0.303
2011 Sturm AC, Mohler PJ. Defining the disconnect between in vitro models and human arrhythmogenic disease: context matters. Circulation. 124: 993-5. PMID 21875919 DOI: 10.1161/Circulationaha.111.051466  0.367
2011 Cunha SR, Hund TJ, Hashemi S, Voigt N, Li N, Wright P, Koval O, Li J, Gudmundsson H, Gumina RJ, Karck M, Schott JJ, Probst V, Le Marec H, Anderson ME, ... ... Mohler PJ, et al. Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation. Circulation. 124: 1212-22. PMID 21859974 DOI: 10.1161/Circulationaha.111.023986  0.382
2011 Mohler PJ, Hund TJ. Membrane-select regulation of cardiac Na(v) channel isoforms. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 8: 1931-2. PMID 21835149 DOI: 10.1016/J.Hrthm.2011.08.002  0.411
2011 Swaminathan PD, Purohit A, Soni S, Voigt N, Singh MV, Glukhov AV, Gao Z, He BJ, Luczak ED, Joiner ML, Kutschke W, Yang J, Donahue JK, Weiss RM, Grumbach IM, ... ... Mohler PJ, et al. Oxidized CaMKII causes cardiac sinus node dysfunction in mice. The Journal of Clinical Investigation. 121: 3277-88. PMID 21785215 DOI: 10.1172/Jci57833  0.328
2011 Boudoulas KD, Mohler PJ. Beyond membrane channelopathies: alternative mechanisms underlying complex human disease. Acta Pharmacologica Sinica. 32: 798-804. PMID 21642948 DOI: 10.1038/Aps.2011.34  0.407
2011 Curran J, Mohler PJ. Coordinating electrical activity of the heart: ankyrin polypeptides in human cardiac disease. Expert Opinion On Therapeutic Targets. 15: 789-801. PMID 21457127 DOI: 10.1517/14728222.2011.575363  0.381
2011 Gao Z, Singh MV, Hall DD, Koval OM, Luczak ED, Joiner ML, Chen B, Wu Y, Chaudhary AK, Martins JB, Hund TJ, Mohler PJ, Song LS, Anderson ME. Catecholamine-independent heart rate increases require Ca2+/calmodulin-dependent protein kinase II. Circulation. Arrhythmia and Electrophysiology. 4: 379-87. PMID 21406683 DOI: 10.1161/Circep.110.961771  0.336
2011 Hund TJ, Mohler PJ. Differential roles for SUR subunits in KATP channel membrane targeting and regulation. American Journal of Physiology. Heart and Circulatory Physiology. 300: H33-5. PMID 21057044 DOI: 10.1152/Ajpheart.01088.2010  0.327
2011 Cunha SR, Mohler PJ. Ankyrin-based cellular pathways for cardiac ion channel and transporter targeting and regulation. Seminars in Cell & Developmental Biology. 22: 166-70. PMID 20934528 DOI: 10.1016/J.Semcdb.2010.09.013  0.414
2011 Mohler PJ, Hund TJ. Role of CaMKII in cardiovascular health, disease, and arrhythmia. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 8: 142-4. PMID 20673813 DOI: 10.1016/J.Hrthm.2010.07.029  0.383
2010 Shan J, Kushnir A, Betzenhauser MJ, Reiken S, Li J, Lehnart SE, Lindegger N, Mongillo M, Mohler PJ, Marks AR. Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice. The Journal of Clinical Investigation. 120: 4388-98. PMID 21099118 DOI: 10.1172/Jci32726  0.384
2010 Hund TJ, Koval OM, Li J, Wright PJ, Qian L, Snyder JS, Gudmundsson H, Kline CF, Davidson NP, Cardona N, Rasband MN, Anderson ME, Mohler PJ. A β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice. The Journal of Clinical Investigation. 120: 3508-19. PMID 20877009 DOI: 10.1172/Jci43621  0.399
2010 Yang J, Huang J, Maity B, Gao Z, Lorca RA, Gudmundsson H, Li J, Stewart A, Swaminathan PD, Ibeawuchi SR, Shepherd A, Chen CK, Kutschke W, Mohler PJ, Mohapatra DP, et al. RGS6, a modulator of parasympathetic activation in heart. Circulation Research. 107: 1345-9. PMID 20864673 DOI: 10.1161/Circresaha.110.224220  0.338
2010 Wolf RM, Mitchell CC, Christensen MD, Mohler PJ, Hund TJ. Defining new insight into atypical arrhythmia: a computational model of ankyrin-B syndrome. American Journal of Physiology. Heart and Circulatory Physiology. 299: H1505-14. PMID 20729400 DOI: 10.1152/Ajpheart.00503.2010  0.45
2010 Ackerman MJ, Mohler PJ. Defining a new paradigm for human arrhythmia syndromes: phenotypic manifestations of gene mutations in ion channel- and transporter-associated proteins. Circulation Research. 107: 457-65. PMID 20724725 DOI: 10.1161/Circresaha.110.224592  0.377
2010 Li J, Kline CF, Hund TJ, Anderson ME, Mohler PJ. Ankyrin-B regulates Kir6.2 membrane expression and function in heart. The Journal of Biological Chemistry. 285: 28723-30. PMID 20610380 DOI: 10.1074/Jbc.M110.147868  0.434
2010 Glukhov AV, Fedorov VV, Anderson ME, Mohler PJ, Efimov IR. Functional anatomy of the murine sinus node: high-resolution optical mapping of ankyrin-B heterozygous mice. American Journal of Physiology. Heart and Circulatory Physiology. 299: H482-91. PMID 20525877 DOI: 10.1152/Ajpheart.00756.2009  0.34
2010 Gudmundsson H, Hund TJ, Wright PJ, Kline CF, Snyder JS, Qian L, Koval OM, Cunha SR, George M, Rainey MA, Kashef FE, Dun W, Boyden PA, Anderson ME, Band H, ... Mohler PJ, et al. EH domain proteins regulate cardiac membrane protein targeting. Circulation Research. 107: 84-95. PMID 20489164 DOI: 10.1161/Circresaha.110.216713  0.389
2010 Koval OM, Guan X, Wu Y, Joiner ML, Gao Z, Chen B, Grumbach IM, Luczak ED, Colbran RJ, Song LS, Hund TJ, Mohler PJ, Anderson ME. CaV1.2 beta-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations. Proceedings of the National Academy of Sciences of the United States of America. 107: 4996-5000. PMID 20194790 DOI: 10.1073/Pnas.0913760107  0.323
2010 Leoni AL, Gavillet B, Rougier JS, Marionneau C, Probst V, Le Scouarnec S, Schott JJ, Demolombe S, Bruneval P, Huang CL, Colledge WH, Grace AA, Le Marec H, Wilde AA, Mohler PJ, et al. Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model. Plos One. 5: e9298. PMID 20174578 DOI: 10.1371/Journal.Pone.0009298  0.341
2010 Hund TJ, Mohler PJ. Cardiac spectrins: alternative splicing encodes functional diversity. Journal of Molecular and Cellular Cardiology. 48: 1031-2. PMID 20144617 DOI: 10.1016/J.Yjmcc.2010.02.002  0.451
2010 Mohler PJ. Sodium channel traffic on the cardiac microtubule highway. Cardiovascular Research. 85: 645-6. PMID 20032082 DOI: 10.1093/Cvr/Cvp404  0.392
2010 Kline CF, Hund TJ, Mohler PJ. Ankyrin regulates KATP channel membrane trafficking and gating in excitable cells. Channels (Austin, Tex.). 4: 55-7. PMID 19901534 DOI: 10.4161/Chan.4.1.10362  0.317
2009 Kline CF, Mohler PJ. From Fifth Business to Protagonist: the complex roles of ion channel anchors in cardiac arrhythmia. Drug Discovery Today. Disease Models. 6: 63-69. PMID 20689672 DOI: 10.1016/J.Ddmod.2009.07.003  0.364
2009 Christensen MD, Dun W, Boyden PA, Anderson ME, Mohler PJ, Hund TJ. Oxidized calmodulin kinase II regulates conduction following myocardial infarction: a computational analysis. Plos Computational Biology. 5: e1000583. PMID 19997488 DOI: 10.1371/Journal.Pcbi.1000583  0.354
2009 Cunha SR, Mohler PJ. Ankyrin protein networks in membrane formation and stabilization Journal of Cellular and Molecular Medicine. 13: 4364-4376. PMID 19840192 DOI: 10.1111/J.1582-4934.2009.00943.X  0.333
2009 Kline CF, Kurata HT, Hund TJ, Cunha SR, Koval OM, Wright PJ, Christensen M, Anderson ME, Nichols CG, Mohler PJ. Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation. Proceedings of the National Academy of Sciences of the United States of America. 106: 16669-74. PMID 19805355 DOI: 10.1073/Pnas.0907138106  0.358
2009 Hashemi SM, Hund TJ, Mohler PJ. Cardiac ankyrins in health and disease. Journal of Molecular and Cellular Cardiology. 47: 203-9. PMID 19394342 DOI: 10.1016/J.Yjmcc.2009.04.010  0.466
2009 Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, Hund TJ, Kutschke W, Sarma S, Grumbach IM, Wehrens XH, Mohler PJ, Song LS, Anderson ME. Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proceedings of the National Academy of Sciences of the United States of America. 106: 5972-7. PMID 19276108 DOI: 10.1073/Pnas.0806422106  0.35
2009 Singh MV, Kapoun A, Higgins L, Kutschke W, Thurman JM, Zhang R, Singh M, Yang J, Guan X, Lowe JS, Weiss RM, Zimmermann K, Yull FE, Blackwell TS, Mohler PJ, et al. Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart. The Journal of Clinical Investigation. 119: 986-96. PMID 19273909 DOI: 10.1172/Jci35814  0.355
2009 Tuvim MJ, Mospan AR, Burns KA, Chua M, Mohler PJ, Melicoff E, Adachi R, Ammar-Aouchiche Z, Davis CW, Dickey BF. Synaptotagmin 2 couples mucin granule exocytosis to Ca2+ signaling from endoplasmic reticulum. The Journal of Biological Chemistry. 284: 9781-7. PMID 19208631 DOI: 10.1074/Jbc.M807849200  0.306
2009 Hund TJ, Wright PJ, Dun W, Snyder JS, Boyden PA, Mohler PJ. Regulation of the ankyrin-B-based targeting pathway following myocardial infarction. Cardiovascular Research. 81: 742-9. PMID 19074823 DOI: 10.1093/Cvr/Cvn348  0.374
2008 Hund TJ, Mohler PJ. Ankyrin-based targeting pathway regulates human sinoatrial node automaticity. Channels (Austin, Tex.). 2: 404-6. PMID 19098452 DOI: 10.4161/Chan.2.6.7220  0.427
2008 Thiel WH, Chen B, Hund TJ, Koval OM, Purohit A, Song LS, Mohler PJ, Anderson ME. Proarrhythmic defects in Timothy syndrome require calmodulin kinase II. Circulation. 118: 2225-34. PMID 19001023 DOI: 10.1161/Circulationaha.108.788067  0.31
2008 Cunha SR, Mohler PJ. Cardiac cytoskeleton and arrhythmia: An unexpected role for protein 4.1R in cardiac excitability Circulation Research. 103: 779-781. PMID 18845816 DOI: 10.1161/Circresaha.108.186460  0.397
2008 Le Scouarnec S, Bhasin N, Vieyres C, Hund TJ, Cunha SR, Koval O, Marionneau C, Chen B, Wu Y, Demolombe S, Song LS, Le Marec H, Probst V, Schott JJ, Anderson ME, ... Mohler PJ, et al. Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease. Proceedings of the National Academy of Sciences of the United States of America. 105: 15617-22. PMID 18832177 DOI: 10.1073/Pnas.0805500105  0.395
2008 Cunha SR, Le Scouarnec S, Schott JJ, Mohler PJ. Exon organization and novel alternative splicing of the human ANK2 gene: Implications for cardiac function and human cardiac disease Journal of Molecular and Cellular Cardiology. 45: 724-734. PMID 18790697 DOI: 10.1016/J.Yjmcc.2008.08.005  0.404
2008 Cunha SR, Mohler PJ. Obscurin targets ankyrin-B and protein phosphatase 2A to the cardiac M-line Journal of Biological Chemistry. 283: 31968-31980. PMID 18782775 DOI: 10.1074/Jbc.M806050200  0.388
2008 Hund TJ, Decker KF, Kanter E, Mohler PJ, Boyden PA, Schuessler RB, Yamada KA, Rudy Y. Role of activated CaMKII in abnormal calcium homeostasis and I(Na) remodeling after myocardial infarction: insights from mathematical modeling. Journal of Molecular and Cellular Cardiology. 45: 420-8. PMID 18639555 DOI: 10.1016/J.Yjmcc.2008.06.007  0.381
2008 Hund TJ, Ziman AP, Lederer WJ, Mohler PJ. The cardiac IP3 receptor: uncovering the role of "the other" calcium-release channel. Journal of Molecular and Cellular Cardiology. 45: 159-61. PMID 18598702 DOI: 10.1016/J.Yjmcc.2008.06.001  0.334
2008 Kline CF, Cunha SR, Lowe JS, Hund TJ, Mohler PJ. Revisiting ankyrin-InsP3 receptor interactions: ankyrin-B associates with the cytoplasmic N-terminus of the InsP3 receptor. Journal of Cellular Biochemistry. 104: 1244-53. PMID 18275062 DOI: 10.1002/Jcb.21704  0.318
2008 Lowe JS, Palygin O, Bhasin N, Hund TJ, Boyden PA, Shibata E, Anderson ME, Mohler PJ. Voltage-gated Nav channel targeting in the heart requires an ankyrin-G dependent cellular pathway. The Journal of Cell Biology. 180: 173-86. PMID 18180363 DOI: 10.1083/Jcb.200710107  0.366
2007 Li J, Marionneau C, Koval O, Zingman L, Mohler PJ, Nerbonne JM, Anderson ME. Calmodulin kinase II inhibition enhances ischemic preconditioning by augmenting ATP-sensitive K+ current. Channels (Austin, Tex.). 1: 387-94. PMID 18690039 DOI: 10.4161/Chan.5449  0.361
2007 Lehnart SE, Ackerman MJ, Benson DW, Brugada R, Clancy CE, Donahue JK, George AL, Grant AO, Groft SC, January CT, Lathrop DA, Lederer WJ, Makielski JC, Mohler PJ, Moss A, et al. Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function. Circulation. 116: 2325-45. PMID 17998470 DOI: 10.1161/Circulationaha.107.711689  0.376
2007 Mohler PJ, Healy JA, Xue H, Puca AA, Kline CF, Allingham RR, Kranias EG, Rockman HA, Bennett V. Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence. Plos One. 2: e1051. PMID 17940615 DOI: 10.1371/Journal.Pone.0001051  0.753
2007 Mohler PJ, Wehrens XHT. Mechanisms of human arrhythmia syndromes: Abnormal cardiac macromolecular interactions Physiology. 22: 342-350. PMID 17928548 DOI: 10.1152/Physiol.00018.2007  0.38
2007 Mohler PJ, Zhu MY, Blade AM, Ham AJL, Shelness GS, Swift LL. Identification of a novel isoform of microsomal triglyceride transfer protein Journal of Biological Chemistry. 282: 26981-26988. PMID 17635917 DOI: 10.1074/Jbc.M700500200  0.317
2007 Bhasin N, Cunha SR, Mudannayake M, Gigena MS, Rogers TB, Mohler PJ. Molecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytes. American Journal of Physiology. Heart and Circulatory Physiology. 293: H109-19. PMID 17416611 DOI: 10.1152/Ajpheart.00059.2007  0.414
2007 Anderson ME, Mohler PJ. MicroRNA may have macro effect on sudden death. Nature Medicine. 13: 410-1. PMID 17415373 DOI: 10.1038/Nm0407-410  0.321
2007 Mohler PJ, Le Scouarnec S, Denjoy I, Lowe JS, Guicheney P, Caron L, Driskell IM, Schott JJ, Norris K, Leenhardt A, Kim RB, Escande D, Roden DM. Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytes. Circulation. 115: 432-41. PMID 17242276 DOI: 10.1161/Circulationaha.106.656512  0.345
2007 Cunha SR, Bhasin N, Mohler PJ. Targeting and stability of Na/Ca exchanger 1 in cardiomyocytes requires direct interaction with the membrane adaptor ankyrin-B. The Journal of Biological Chemistry. 282: 4875-83. PMID 17178715 DOI: 10.1074/Jbc.M607096200  0.376
2007 Kizhatil K, Yoon W, Mohler PJ, Davis LH, Hoffman JA, Bennett V. Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells. The Journal of Biological Chemistry. 282: 2029-37. PMID 17074766 DOI: 10.1074/Jbc.M608921200  0.692
2006 Kline CF, Mohler PJ. Weighing in on molecular anchors: The role of ankyrin polypeptides in human arrhythmia Expert Review of Cardiovascular Therapy. 4: 477-485. PMID 16918266 DOI: 10.1586/14779072.4.4.477  0.439
2006 Mohler PJ. Ankyrins and human disease: What the electrophysiologist should know Journal of Cardiovascular Electrophysiology. 17: 1153-1159. PMID 16800854 DOI: 10.1111/J.1540-8167.2006.00540.X  0.435
2006 Cunha SR, Mohler PJ. Cardiac ankyrins: Essential components for development and maintenance of excitable membrane domains in heart Cardiovascular Research. 71: 22-29. PMID 16650839 DOI: 10.1016/j.cardiores.2006.03.018  0.371
2006 Hodson CA, Ambrogi IG, Scott RO, Mohler PJ, Milgram SL. Polarized apical sorting of guanylyl cyclase C is specified by a cytosolic signal. Traffic (Copenhagen, Denmark). 7: 456-64. PMID 16536743 DOI: 10.1111/J.1600-0854.2006.00398.X  0.732
2006 Abdi KM, Mohler PJ, Davis JQ, Bennett V. Isoform specificity of ankyrin-B: a site in the divergent C-terminal domain is required for intramolecular association. The Journal of Biological Chemistry. 281: 5741-9. PMID 16368689 DOI: 10.1074/Jbc.M506697200  0.684
2005 Mohler PJ, Lowe JS, Banks S. Dysfunction in ankyrin-based cellular pathways and human cardiac arrhythmia. Future Cardiology. 1: 363-71. PMID 19804119 DOI: 10.1517/14796678.1.3.363  0.441
2005 Mohler PJ, Davis JQ, Bennett V. Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain. Plos Biology. 3: e423. PMID 16292983 DOI: 10.1371/Journal.Pbio.0030423  0.52
2005 Mohler PJ, Bennett V. Defects in ankyrin-based cellular pathways in metazoan physiology. Frontiers in Bioscience : a Journal and Virtual Library. 10: 2832-40. PMID 15970537  0.484
2005 Mohler PJ, Bennett V. Ankyrin-based cardiac arrhythmias: a new class of channelopathies due to loss of cellular targeting. Current Opinion in Cardiology. 20: 189-93. PMID 15861006 DOI: 10.1097/01.Hco.0000160372.95116.3E  0.589
2004 Mohler PJ, Rivolta I, Napolitano C, LeMaillet G, Lambert S, Priori SG, Bennett V. Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. Proceedings of the National Academy of Sciences of the United States of America. 101: 17533-8. PMID 15579534 DOI: 10.1073/Pnas.0403711101  0.552
2004 Mohler PJ, Yoon W, Bennett V. Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes. The Journal of Biological Chemistry. 279: 40185-93. PMID 15262991 DOI: 10.1074/Jbc.M406018200  0.668
2004 Mohler PJ, Splawski I, Napolitano C, Bottelli G, Sharpe L, Timothy K, Priori SG, Keating MT, Bennett V. A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. Proceedings of the National Academy of Sciences of the United States of America. 101: 9137-42. PMID 15178757 DOI: 10.1073/Pnas.0402546101  0.593
2004 Mohler PJ, Hoffman JA, Davis JQ, Abdi KM, Kim CR, Jones SK, Davis LH, Roberts KF, Bennett V. Isoform specificity among ankyrins. An amphipathic alpha-helix in the divergent regulatory domain of ankyrin-b interacts with the molecular co-chaperone Hdj1/Hsp40. The Journal of Biological Chemistry. 279: 25798-804. PMID 15075330 DOI: 10.1074/Jbc.M401296200  0.698
2004 Mohler PJ, Davis JQ, Davis LH, Hoffman JA, Michaely P, Bennett V. Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B. The Journal of Biological Chemistry. 279: 12980-7. PMID 14722080 DOI: 10.1074/Jbc.M313979200  0.538
2003 Wehrens XH, Lehnart SE, Huang F, Vest JA, Reiken SR, Mohler PJ, Sun J, Guatimosim S, Song LS, Rosemblit N, D'Armiento JM, Napolitano C, Memmi M, Priori SG, Lederer WJ, et al. FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell. 113: 829-40. PMID 12837242 DOI: 10.1016/S0092-8674(03)00434-3  0.388
2003 Mohler PJ, Schott JJ, Gramolini AO, Dilly KW, Guatimosim S, duBell WH, Song LS, Haurogné K, Kyndt F, Ali ME, Rogers TB, Lederer WJ, Escande D, Le Marec H, Bennett V. Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Nature. 421: 634-9. PMID 12571597 DOI: 10.1038/Nature01335  0.609
2002 Mohler PJ, Gramolini AO, Bennett V. Ankyrins. Journal of Cell Science. 115: 1565-6. PMID 11950874  0.421
2002 Mohler PJ, Kultgen PL, Stutts MJ, Milgram SL. Biochemical assays for studying indirect interactions between CFTR and the cytoskeleton. Methods in Molecular Medicine. 70: 383-94. PMID 11917538 DOI: 10.1385/1-59259-187-6:383  0.722
2002 Mohler PJ, Gramolini AO, Bennett V. The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes. The Journal of Biological Chemistry. 277: 10599-607. PMID 11781319 DOI: 10.1074/Jbc.M110958200  0.56
1999 Mohler PJ, Kreda SM, Boucher RC, Sudol M, Stutts MJ, Milgram SL. Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50. The Journal of Cell Biology. 147: 879-90. PMID 10562288 DOI: 10.1083/Jcb.147.4.879  0.634
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